keyword
https://read.qxmd.com/read/38490491/proposals-for-the-delineation-of-neck-clinical-target-volume-for-definitive-radiation-therapy-in-patients-with-oral-oropharyngeal-squamous-cell-cancer-based-on-lymph-node-distribution
#21
JOURNAL ARTICLE
Yun-Chang Liu, Xin Zhang, Hao-Nan Yang, Lu Zhang, Dan Li, Meng-Qi Yang, Nuo-Han Wang, Yong-Zhong Wu, Jiang-Dong Sui, Ying Wang
PURPOSE/OBJECTIVE(S): To establish the distribution pattern of cervical lymph node metastasis (LNM) and propose optimized clinical target volume (CTV) boundaries specific to oral/ oropharyngeal squamous cell cancer (OSCC/OPSCC). MATERIALS/METHODS: 531 patients with pathologically confirmed OSCC/OPSCC were enrolled from January 2013 to June 2022. Patients were stratified into two groups based on the minimal distance from the lesion's edge to the body's midline: ≤1 cm or > 1 cm...
March 13, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38490294/unleashing-the-potential-of-oral-deliverable-nanomedicine-in-the-treatment-of-inflammatory-bowel-disease
#22
REVIEW
Chunhua Yang, Kripa Sharma, Rabeya Jafrin Mow, Eunice Bolay, Anand Srinivasan, Didier Merlin
Inflammatory Bowel Disease (IBD), marked by chronic gastrointestinal tract inflammation, poses a significant global medical challenge. Current treatments for IBD, including corticosteroids, immunomodulators, and biologics, often require frequent systemic administration through parenteral delivery, leading to non-specific drug distribution, suboptimal therapeutic outcomes, and adverse effects. There is a pressing need for a targeted drug delivery system (DDS) to enhance drug efficacy and minimize its systemic impact...
March 13, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38490031/isolated-scrotal-lymphedema-in-a-43-year-old-male-patient-a-case-report
#23
Ghazal Talal Saeed, Donia Ahmad, Montaser Nabeeh Al Smady, Gunjan Awatramani, Tariq Abdul Hamid, Farhad Janahi
INTRODUCTION: Lymphedema of the external genitalia is a rare condition characterized by swelling of the scrotal skin and subcutaneous tissue, resulting from a pathology in lymphatic drainage. Over time, the development of fibrosis leads to a considerable impairment in the patient's quality of life. While conservative management is generally the first-line approach, surgical cases may necessitate surgical intervention to achieve comprehensive and lasting improvements. CASE PRESENTATION: We present the case of a 43-year-old obese male patient who presented to the clinic with a complaint of persistent bilateral scrotal swelling for three months...
February 23, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38488908/clinical-insights-into-traumatic-injury-of-the-inferior-alveolar-and-lingual-nerves-a-comprehensive-approach-from-diagnosis-to-therapeutic-interventions
#24
REVIEW
Peer W Kämmerer, Diana Heimes, Amely Hartmann, Marco Kesting, Fouad Khoury, Eik Schiegnitz, Daniel G E Thiem, Jörg Wiltfang, Bilal Al-Nawas, Wolfgang Kämmerer
OBJECTIVES: This scoping review explores the risk and management of traumatic injuries to the inferior alveolar and lingual nerves during mandibular dental procedures. Emphasizing the significance of diagnostic tools, the review amalgamates existing knowledge to offer a comprehensive overview. MATERIALS AND METHODS: A literature search across PubMed, Embase, and Cochrane Library informed the analysis. RESULTS: Traumatic injuries often lead to hypo-/anesthesia and neuropathic pain, impacting individuals psychologically and socially...
March 15, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38488469/optimization-strategies-and-advances-in-the-research-and-development-of-aav-based-gene-therapy-to-deliver-large-transgenes
#25
REVIEW
Valeria V Kolesnik, Ruslan F Nurtdinov, Ezekiel Sola Oloruntimehin, Alexander V Karabelsky, Alexander S Malogolovkin
Adeno-associated virus (AAV)-based therapies are recognized as one of the most potent next-generation treatments for inherited and genetic diseases. However, several biological and technological aspects of AAV vectors remain a critical issue for their widespread clinical application. Among them, the limited capacity of the AAV genome significantly hinders the development of AAV-based gene therapy. In this context, genetically modified transgenes compatible with AAV are opening up new opportunities for unlimited gene therapies for many genetic disorders...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38488215/flexible-and-stretchable-implantable-devices-for-peripheral-neuromuscular-electrophysiology
#26
REVIEW
Hanfei Li, Hang Zhao, Kaikai Song, Fei Han, Zhiyuan Liu, Qiong Tian
The peripheral nervous and muscular system, a cornerstone of human physiology, plays a pivotal role in ensuring the seamless functioning of the human body. This intricate network, comprising nerves and muscles extending throughout the body, is essential for motor control, sensory feedback, and the regulation of autonomic bodily functions. The qualified implantable peripheral interface can accurately monitor the biopotential of the target tissue and conduct treatment with stimulation, enhancing the human-machine interaction and new achievements in disease cure...
March 15, 2024: Nanoscale
https://read.qxmd.com/read/38486748/the-clinical-impact-of-mrna-therapeutics-in-the-treatment-of-cancers-infections-genetic-disorders-and-autoimmune-diseases
#27
REVIEW
Roham Deyhimfar, Mehrnaz Izady, Mohammadreza Shoghi, Mohammad Hossein Kazazi, Zahra Fakhraei Ghazvini, Hojjatollah Nazari, Zahra Fekrirad, Ehsan Arefian
mRNA-based therapeutics have revolutionized medicine and the pharmaceutical industry. The recent progress in the optimization and formulation of mRNAs has led to the development of a new therapeutic platform with a broad range of applications. With a growing body of evidence supporting the use of mRNA-based drugs for precision medicine and personalized treatments, including cancer immunotherapy, genetic disorders, and autoimmune diseases, this emerging technology offers a rapidly expanding category of therapeutic options...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38486733/percutaneous-coronary-intervention-versus-optimal-medical-therapy-for-stable-coronary-artery-disease-an-umbrella-review
#28
JOURNAL ARTICLE
David R Soriano-Moreno, Daniel Fernandez-Guzman, Kimberly G Tuco, Anderson N Soriano-Moreno, Fabricio Ccami-Bernal, Abdiel H Coico-Lama, Antony G Gonzáles-Uribe, Alvaro Taype-Rondan
BACKGROUND: Invasive management of stable coronary artery disease is still a controversial topic. The purpose of this umbrella review was to synthesize systematic reviews (SRs) that evaluate the benefits and harms of percutaneous coronary intervention (PCI) versus optimal medical therapy (OMT) in patients with stable coronary artery disease. METHODS: We systematically searched PubMed/MEDLINE, Embase, and CENTRAL from 2018 to August 7, 2022. We included SRs with meta-analyses of randomized controlled trials (RCTs) that evaluated the question of interest...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38485677/assessment-of-monitoring-and-management-practices-of-antipsychotic-induced-hyperprolactinemia-at-a-medical-city-in-riyadh-saudi-arabia-a-retrospective-cohort-study
#29
JOURNAL ARTICLE
Zahra Hussain Alshabeeb, Bashayr Alsuwayni, Omar Alshargi, Ahmed H Abdelazeem
BACKGROUND: Hyperprolactinemia is a commonly underestimated adverse effect of antipsychotic medications. There are still no consensus guidelines for the optimal monitoring and treatment strategies. OBJECTIVE: The aim of the study was to assess the monitoring and treatment practices of antipsychotic- induced hyperprolactinemia, in addition to the prevalence and risk factors associated with it. METHODS: A retrospective cohort observational study was conducted among patients attending the psychiatric clinics at an academic tertiary hospital in Riyadh, Saudi Arabia, from May 2020 until May 2021, by reviewing each patient's medical record for up to five years...
March 12, 2024: Current Drug Safety
https://read.qxmd.com/read/38484788/overview-of-rheumatoid-arthritis-associated-interstitial-lung-disease-and-its-treatment
#30
JOURNAL ARTICLE
Janelle Vu Pugashetti, Joyce S Lee
Interstitial lung disease (ILD) is a common pulmonary complication of rheumatoid arthritis (RA), causing significant morbidity and mortality. Optimal treatment for RA-ILD is not yet well defined. Reliable prognostic indicators are largely byproducts of prior ILD progression, including low or decreasing forced vital capacity and extensive or worsening fibrosis on imaging. In the absence of validated tools to predict treatment response, decisions about whether to initiate or augment treatment are instead based on clinical judgment...
March 14, 2024: Seminars in Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38484438/yoga-nidra-for-hypertension-a-systematic-review-and-meta-analysis
#31
REVIEW
Navdeep Ahuja, Praag Bhardwaj, Monika Pathania, Dilasha Sethi, Arjun Kumar, Ashwin Parchani, Akshita Chandel, Aashish Phadke
BACKGROUND: Hypertension is a prevalent chronic condition that affects a substantial proportion of the world's population. Medications are commonly prescribed for hypertension management, but non-pharmacological interventions like yoga are gaining popularity. OBJECTIVE: The purpose of this systematic review and meta-analysis is to assess the efficacy of Yoga Nidra (YN) for the management of hypertension. METHODS: A systematic review and meta-analysis of clinical trials, i...
March 13, 2024: Journal of Ayurveda and Integrative Medicine
https://read.qxmd.com/read/38484211/family-recall-of-and-response-to-germline-pathologic-variants-found-on-paired-tumor-germline-sequencing-in-pediatric-oncology
#32
JOURNAL ARTICLE
Michelle F Jacobs, Joshua W Goldman, Sarah Austin, Erika S Koeppe, Andrea M Murad, Carl J Koschmann, Arul M Chinnaiyan, Rajen J Mody
PURPOSE: Paired tumor-germline sequencing can identify somatic variants for targeted therapy and germline pathogenic variants (GPVs) causative of hereditary cancer/tumor predisposition syndromes. It is unknown how patients/families in pediatric oncology use information about an identified GPV. We assessed recall of germline results and actions taken on the basis of findings. METHODS: We completed phone surveys with patients (and/or their parent) with GPVs identified via a single academic medical center's paired tumor-germline sequencing study...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38483737/comparison-of-the-efficacy-of-acupuncture-with-tuina-with-acupuncture-only-in-the-treatment-of-peripheral-facial-paralysis-a-network-meta-analysis
#33
REVIEW
Xinyuan Deng, Hao Zhu, Luyan Shi, Yanting Li, Haiping Shi, Yicheng Wu, Yu Zhang
At present, traditional Chinese medicine treatment is considered safe for treating peripheral facial paralysis (PFP). Acupuncture-only and acupuncture combined with tuina are widely used for this purpose. However, it is not clear whether acupuncture combined with tuina is better for treating PFP than acupuncture-only. Conventional meta-analysis and network meta-analysis were used to compare the clinical efficacies of acupuncture combined with tuina and acupuncture-only in the treatment of PFP. Randomized controlled trials (RCTs), with the subjects being patients with PFP and treatment interventions including acupuncture combined with tuina, acupuncture-only, tuina-only, placebo, single Western medicine, and steroids combined with other Western medicine were searched from both Chinese and English databases...
March 14, 2024: Internal and Emergency Medicine
https://read.qxmd.com/read/38482428/combinatory-glycoengineering-of-monoclonal-antibodies-and-its-application-in-cancer-therapy-a-narrative-review
#34
REVIEW
Siyuan Wang, Huairu Tian, Peilin Tian, Yiwen Xing, Yuan Zeng
BACKGROUND AND OBJECTIVE: The application of immunotherapy, especially in terms of recombinant monoclonal antibodies (mAbs), is a revolution in the pharmaceutical industry field. Glycosylation plays an essential role in the structures and functions of mAbs, which must be carefully monitored and designed throughout their entire lifespan to ensure safety and efficacy. This review aimed to summarize the current status of the glycoengineering of mAbs for providing reference for the pharmaceutical industry...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38482421/beginning-of-clinical-treatment-using-the-1-5-tesla-mr-linac-system-in-japan-a-narrative-review
#35
REVIEW
Noriyoshi Takahashi, Shohei Tanaka, Rei Umezawa, Takaya Yamamoto, Yu Suzuki, Keita Kishida, So Omata, Kazuhiro Arai, Yoshiyuki Katsuta, Noriyuki Kadoya, Keiichi Jingu
BACKGROUND AND OBJECTIVE: In the field of radiation therapy, image-guided radiotherapy (IGRT) technology has been gradually improving and highly accurate radiation treatment has been possible. Research on IGRT using 1.5 Tesla magnetic resonance imaging (MRI) began in 1999, and a radiation therapy device called 1.5 Tesla magnetic resonance linear accelerator (MR-Linac), which combines a linear accelerator with 1.5 Tesla MRI, was developed in Europe. The aim of this review is to present an overview of 1...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38482388/evaluation-of-guideline-directed-medical-therapy-for-outpatients-living-with-heart-failure-with-reduced-ejection-fraction
#36
JOURNAL ARTICLE
Taylor McVannel, Lori Albers, Lynette Kosar, Brittani Reid, Colin Yeung, Muhammad Siddiqui, Oleksandr Baran
BACKGROUND: Pharmacotherapy is the cornerstone of treatment for heart failure with reduced ejection fraction (HFrEF). The Canadian Cardiovascular Society and Canadian Heart Failure Society have defined guideline-directed medical therapy (GDMT) as 4 foundational medications. Despite strong recommendations for use of GDMT in HFrEF, current practice alignment with guidelines is unknown. OBJECTIVES: The primary objectives were to determine the proportion of patients for whom optimized GDMT for HFrEF was prescribed, to describe the doses of foundational medications achieved, and to describe any documented rationale limiting the optimization of GDMT...
2024: Canadian Journal of Hospital Pharmacy
https://read.qxmd.com/read/38481952/effects-of-different-traditional-chinese-exercise-in-the-treatment-of-essential-hypertension-a-systematic-review-and-network-meta-analysis
#37
REVIEW
Qingyuan Zhang, Xiaogang Xu, Qianyan Wu, Jingwen Zhang, Shenghe Huang, Lin Wu, Minping Tian, Delin Zhang
BACKGROUND: As a therapy to prevent and treat essential hypertension (EH), traditional Chinese exercises (TCEs) were widely used in clinical practice. However, there is a lack of strictly comparison of the antihypertensive efficacy of different TCEs, which not conducive to the selection of the best and most optimal treatment. This study aimed to perform a network meta-analysis to objectively evaluate which TCE has the best effects in assisting with lowering blood pressure. METHODS: PubMed, Embase, the Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), VIP, SinoMed and Wanfang Data were searched for all randomized controlled trials (RCTs) on TCEs for the treatment of EH published up to July 10, 2023...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38481920/understanding-ocular-surface-disease-in-glaucoma-a-comparative-analysis-of-symptoms-and-objective-parameters
#38
JOURNAL ARTICLE
João Romano, Nélia Ferreira, Gonçalo Godinho, Rita Tomás, Nuno Oliveira, João Paulo Sousa
Background Glaucoma is a progressive optic neuropathy that may result in irreversible visual impairment and can diminish quality of life. Lowering intraocular pressure (IOP) through topical eyedrops is usually the primary approach to managing glaucoma. However, long-term treatment poses a risk to ocular surface health, leading to ocular surface disease (OSD). Preservative-containing eyedrops are implicated in OSD development due to their detrimental effects on the tear film and goblet cell density. OSD symptoms may impact patient compliance due to local side effects...
February 2024: Curēus
https://read.qxmd.com/read/38481857/a-narrative-review-of-management-of-muscle-invasive-bladder-cancer-perioperative-period-will-continuous-and-combined-treatment-be-the-new-trend
#39
REVIEW
Tianhang Lan, Shengming Ran, Mingchao Gao, Wenjie Li, Wang He
BACKGROUND AND OBJECTIVE: With the emergence of immunotherapy and targeted therapies, there are more options for the perioperative period management of muscle-invasive bladder cancer (MIBC), and various types of clinical studies are emerging, leading to the need to explore ways to choose the optimal treatment modality. This review aims to synthesize past and present treatment modalities and to explore future trends in the perioperative period cares of MIBC for the benefit of clinical practitioners...
February 29, 2024: Translational Andrology and Urology
https://read.qxmd.com/read/38481726/real-world-data-a-comprehensive-literature-review-on-the-barriers-challenges-and-opportunities-associated-with-their-inclusion-in-the-health-technology-assessment-process
#40
JOURNAL ARTICLE
Konstantinos Zisis, Elpida Pavi, Mary Geitona, Kostas Athanasakis
Objective: This review aimed to assess the current use and acceptance of real-world data (RWD) and real-world evidence (RWE) in health technology assessment (HTA) process. It additionally aimed to discern stakeholders' viewpoints concerning RWD and RWE in HTA and illuminate the obstacles, difficulties, prospects, and consequences associated with the incorporation of RWD and RWE into the realm of HTA. Methods: A comprehensive PRISMA-based systematic review was performed in July 2022 in PubMed/Medline, Scopus, IDEAS-RePEc, International HTA database, and Centre for Reviews and Dissemination with ad hoc supplementary search in Google Scholar and international organization websites...
2024: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
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