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https://www.readbyqxmd.com/read/28213896/filaggrin-loss-of-function-mutations-atopic-dermatitis-and-risk-of-actinic-keratosis-results-from-two-cross-sectional-studies
#1
Y M F Andersen, A Egeberg, E Balslev, C L T Jørgensen, P B Szecsi, S Stender, J Kaae, A Linneberg, G Gislason, L Skov, P M Elias, J P Thyssen
BACKGROUND: Common loss-of-function mutations in filaggrin gene (FLG) represent a strong genetic risk factor for atopic dermatitis (AD). Homozygous mutation carriers typically display ichthyosis vulgaris (IV) and many have concomitant AD. Previously, homozygous, but not heterozygous, filaggrin gene mutations have been associated with squamous cell carcinomas. OBJECTIVE: The first objective was to examine the association between FLG mutations and actinic keratosis (AK)...
February 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28196317/common-skin-conditions-in-children-noninfectious-rashes
#2
Brian Z Rayala, Dean S Morrell
Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Emollients and topical corticosteroids are first-line therapies. Topical calcineurin inhibitors are second-line, steroid-sparing drugs for certain conditions, such as face and eyelid eczema...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28196316/common-skin-conditions-in-children-neonatal-skin-lesions
#3
Brian Z Rayala, Dean S Morrell
Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Clinicians need to recognize these benign skin conditions and differentiate them from more serious conditions, such as infectious pustular eruptions from bacterial, viral, and fungal causes, and inflammatory conditions, such as Langerhans cell histiocytosis...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28195077/effects-of-air-pollution-on-the-skin-a-review
#4
REVIEW
Poonam Puri, Shashi Kumar Nandar, Sushruta Kathuria, V Ramesh
The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Although human skin acts as a biological shield against pro-oxidative chemicals and physical air pollutants, prolonged or repetitive exposure to high levels of these pollutants may have profound negative effects on the skin...
February 7, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28191680/friends-or-foes-host-defense-antimicrobial-peptides-and-proteins-in-human-skin-diseases
#5
REVIEW
François Niyonsaba, Chanisa Kiatsurayanon, Panjit Chieosilapatham, Hideoki Ogawa
Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28190621/the-histopathological-differentiation-between-palmar-psoriasis-and-hand-eczema-a-retrospective-review-of-96-cases
#6
Jun Yeong Park, Eun Byul Cho, Eun Joo Park, Hye Rim Park, Kwang Ho Kim, Kwang Joong Kim
BACKGROUND: The histopathologic differences among palmar psoriasis (PP), hand eczema (HE), and hyperkeratotic hand dermatitis (HHD) have been poorly described. OBJECTIVES: We sought to distinguish among PP, HE, and HHD on a histopathologic basis. METHODS: We retrospectively analyzed the histology of hematoxylin-eosin-stained sections obtained from 96 patients diagnosed with PP, HE, or HHD. RESULTS: The patients were divided into 4 subgroups: PP (n = 16, group A), HE without atopic or nummular dermatitis (n = 41, group B), HE with atopic or nummular dermatitis (n = 14, group C), and HHD (n = 25, group D)...
February 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28188596/treatment-adherence-intervention-studies-in-dermatology-and-guidance-on-how-to-support-adherence
#7
REVIEW
Steven R Feldman, Bernard Vrijens, Uwe Gieler, Stefano Piaserico, Lluís Puig, Peter van de Kerkhof
Adequate adherence to prescribed treatment regimens can help to break the cycle of treatment failure, disease progression and subsequent treatment escalation. Unfortunately, adherence in the treatment of skin disorders such as acne, atopic dermatitis/eczema and psoriasis is often inadequate. A review of the literature identified a number of studies that tested an intervention to improve adherence in dermatology, including the following: electronic messages and/or reminders; more frequent or 'extra' clinic visits; audio-visual and internet-based interventions; and patient support programmes and/or self-management, educational training programmes...
February 10, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28186503/a-novel-dlx3-pkc-integrated-signaling-network-drives-keratinocyte-differentiation
#8
Elisabetta Palazzo, Meghan D Kellett, Christophe Cataisson, Paul W Bible, Shreya Bhattacharya, Hong-Wei Sun, Anna C Gormley, Stuart H Yuspa, Maria I Morasso
Epidermal homeostasis relies on a well-defined transcriptional control of keratinocyte proliferation and differentiation, which is critical to prevent skin diseases such as atopic dermatitis, psoriasis or cancer. We have recently shown that the homeobox transcription factor DLX3 and the tumor suppressor p53 co-regulate cell cycle-related signaling and that this mechanism is functionally involved in cutaneous squamous cell carcinoma development. Here we show that DLX3 expression and its downstream signaling depend on protein kinase C α (PKCα) activity in skin...
February 10, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28178365/development-and-clinical-validation-of-a-novel-photography-based-skin-erythema-evaluation-system-a-comparison-with-the-calculated-consensus-of-dermatologists
#9
M Cho, D-H Lee, E J Doh, Y Kim, J H Chung, H C Kim, S Kim
Erythema is the most common presenting sign of skin conditions [1,2]. Erythema reflects the degree of inflammation associated with various diseases, such as atopic dermatitis, psoriasis, and lupus erythematosus; it is also cosmetically troublesome in subjects with flushing, rosacea, and photoaging [3,4]. In addition, there are vascular disorders that present with erythema, such as nevus flammeus, telangiectasia, and post-acne erythema [5]. Various therapeutic devices, medicines, and cosmetics have been developed to improve these dermatological conditions [6,7]...
February 8, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28162227/angiogenesis-in-dermatology-insights-of-molecular-mechanisms-and-latest-developments
#10
N A Richarz, A Boada, J M Carrascosa
Angiogenesis is the growth of new blood vessels from pre-existing vessels. It is a biological process essential in physiological wound healing or pathological inflammation and tumor growth, which underlies a complex interplay of stimulating and inhibiting signals. Extracellular matrix, cells of innate and adaptive immunity and endothelial cells itself are a major source of angiogenic factors that activate or inhibit specific receptors and consequently influence intracellular signaling pathways. Most inflammatory and neoplastic diseases in dermatology are characterized by excessive angiogenesis, such as psoriasis, atopic dermatitis, as well as melanoma, non-melanoma skin cancer, but also benign vascular neoplasia...
February 2, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28150106/psoriasis-and-atopic-dermatitis
#11
REVIEW
Christopher E M Griffiths, Peter van de Kerkhof, Magdalena Czarnecka-Operacz
Psoriasis and atopic dermatitis are common, chronic inflammatory skin diseases. We discuss several aspects of these disorders, including: risk factors; incidence and prevalence; the complex disease burden; and the comorbidities that increase the clinical significance of each disorder. We also focus on treatment management strategies and outline why individualized, patient-centered treatment regimens should be part of the care plans for patients with either psoriasis or atopic dermatitis. Finally, we conclude that, while our theoretical knowledge of the optimum care plans for these patients is increasingly sophisticated, this understanding is, unfortunately, not always reflected in daily clinical practice...
January 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28148916/innate-lymphoid-cells-in-autoimmunity-emerging-regulators-in-rheumatic-diseases
#12
REVIEW
Medya M Shikhagaie, Kristine Germar, Suzanne M Bal, Xavier Romero Ros, Hergen Spits
Innate lymphoid cells (ILCs) are important in the regulation of barrier homeostasis. These cells do not express T cell receptors but share many functional similarities with T helper cells and cytotoxic CD8(+) T lymphocytes. ILCs are divided into three groups, namely group 1 ILCs, group 2 ILCs and group 3 ILCs, based on the transcription factors they depend on for their development and function, and the cytokines they produce. Emerging data indicate that ILCs not only have protective functions but can also have detrimental effects when dysregulated, leading to chronic inflammation and autoimmune diseases, including asthma, inflammatory bowel disease, graft-versus-host disease, psoriasis, rheumatoid arthritis and atopic dermatitis...
February 2, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28139263/jak-inhibitors-in-dermatology-the-promise-of-a-new-drug-class
#13
REVIEW
William Damsky, Brett A King
New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase-signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling pathway upon which many different proinflammatory signaling pathways converge. Numerous inflammatory dermatoses are driven by soluble inflammatory mediators, which rely on JAK-STAT signaling, and inhibition of this pathway using JAK inhibitors might be a useful therapeutic strategy for these diseases. Growing evidence suggests that JAK inhibitors are efficacious in atopic dermatitis, alopecia areata, psoriasis, and vitiligo...
January 28, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28133819/use-of-phototherapy-in-children
#14
Karen Eustace, Sophie Dolman, Ali Alsharqi, Graham Sharpe, Richard Parslew
BACKGROUND: Phototherapy is a well-recognized treatment in adults and children. Previous articles have reported success in treating recalcitrant skin disorders such as atopic dermatitis (AD), psoriasis, pityriasis lichenoides chronica, and vitiligo in children. METHODS: This was a retrospective review over an 18-month period from June 2012 to December 2013 of all children receiving phototherapy in a tertiary pediatric dermatology center. RESULTS: Seventy-five patients 3 to 17 years of age (mean 10...
January 30, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28131799/janus-kinase-inhibitors-display-broad-anti-itch-properties-a-possible-link-via-the-trpv1-receptor
#15
Tomoki Fukuyama, Joy Rachel Ganchingco, Santosh K Mishra, Thierry Olivry, Ignacy Rzagalinski, Dietrich A Volmer, Wolfgang Bäumer
The antipruritic effect of JAK inhibitors is fast and sustained in dogs with atopic dermatitis and in human patients with psoriasis. The inhibitory profiles of these molecules might be more related to their direct inhibition of TRPV1 rather than that of JAKs.
January 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28128078/distribution-of-malassezia-species-in-patients-with-different-dermatological-disorders-and-healthy-individuals
#16
Asja Prohić, Tamara Jovović Sadiković, Suada Kuskunović-Vlahovljak, Rusmir Baljić
There are differences with respect to the commonly isolated Malassezia species, not only between healthy individuals and the patients with various skin diseases, but also between different countries. We investigated the species composition of Malassezia microflora on the skin of patients with Malassezia-associated diseases and of healthy subjects (HS). Two hundred and fifty skin scrapings from patients with pityriasis versicolor (PV), seborrheic dermatitis (SD), atopic dermatitis (AD), psoriasis (PS), and healthy subjects (HS), fifty each, were inoculated into Sabouraud dextrose agar and into modified Dixon agar and identified using conventional culture-based methods...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28119993/gallstone-risk-in-adult-patients-with-atopic-dermatitis-and-psoriasis-possible-effect-of-overweight-and-obesity
#17
Alexander Egeberg, Yuki M F Andersen, Gunnar H Gislason, Lone Skov, Jacob P Thyssen
Adult atopic dermatitis (AD) is associated with overweight, obesity and cardiovascular diseases (CVD) in Americans, similarly to psoriasis, but no increased risk of CVD has been shown in European patients with AD. This study investigated the prevalence and risk of gallstones in adults with AD and in those with psoriasis as a proxy for obesity using nationwide data for all Danish citizens ≥ 30 years of age. Outcome was a diagnosis of gallstones. Odds ratios (ORs) were calculated by logistic regression (cross-sectional study) and hazard ratios (HRs) were estimated by Cox regression (cohort study)...
January 25, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28117878/siramesine-causes-preferential-apoptosis-of-mast-cells-in-skin-biopsies-from-psoriatic-lesions
#18
E Hagforsen, M Lampinen, A Paivandy, S Weström, H Velin, S Öberg, G Pejler, O Rollman
BACKGROUND: Skin mast cells are implicated as detrimental effector cells in various inflammatory skin diseases such as contact eczema, atopic dermatitis and psoriasis. Selective reduction of cutaneous mast cells, e.g. by inducing targeted apoptosis, might prove a rational and efficient therapeutic strategy in dermatoses negatively influenced by mast cells. OBJECTIVES: The objective of the present study was to evaluate whether a lysosomotropic agent such as siramesine can cause apoptosis of mast cells present in psoriatic lesions...
January 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28109691/erectile-dysfunction-in-male-adults-with-atopic-dermatitis-and-psoriasis
#19
Alexander Egeberg, Peter R Hansen, Gunnar H Gislason, Lone Skov, Jacob P Thyssen
INTRODUCTION: Patients with psoriasis have increased risk of cardiovascular disease, but data on atopic dermatitis (AD) are less clear-cut. However, it is well-established that erectile dysfunction (ED) can serve as a risk marker for coronary disease. AIM: To investigate the incidence, prevalence, and risk of ED in men with psoriasis and AD. METHODS: The sample included all Danish men at least 30 years old. In patients with AD and psoriasis, we determined disease severity based on use of systemic therapy...
January 18, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28106273/the-immunoglobulin-superfamily-member-cd200r-identifies-cells-involved-in-type-2-immune-responses
#20
Lars H Blom, Britta C Martel, Lau F Larsen, Camilla V Hansen, Malene P Christensen, Nanna Juel-Berg, Thomas Litman, Lars K Poulsen
BACKGROUND: The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. METHODS: Naïve human CD4(+) T-cells were short-term activated in the presence or absence of IL-4, and analysed for expression of >300 cell-surface proteins...
January 20, 2017: Allergy
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