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https://www.readbyqxmd.com/read/28239958/differential-sex-effects-of-systolic-blood-pressure-and-ldl-c-on-type-2-diabetes-life-course-data-from-the-bogalusa-heart-study
#1
Benjamin D Pollock, Wei Chen, Emily W Harville, Tian Shu, Vivian Fonseca, Franck Mauvais-Jarvis, Tanika N Kelly, Lydia A Bazzano
BACKGROUND: There may be sex-specific cardiometabolic mechanisms early in life that affect the development of type 2 diabetes (T2DM) through mid-adulthood. Yet, there have been few studies examining whether early life-course interactions between cardiometabolic risk factors and sex are associated with incident T2DM. METHODS: We followed n = 7,725 children from the Bogalusa Heart Study through mid-adulthood to examine whether low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), body mass index (BMI), or systolic blood pressure (SBP) differentially impact the risk of T2DM for females versus males...
February 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28239945/the-effect-of-viewing-video-clips-of-paediatric-local-anaesthetic-administration-on-the-confidence-of-undergraduate-dental-students
#2
K P Kenny, A M Alkazme, P F Day
INTRODUCTION: Dental treatment for children requires not only technical skills, but also the knowledge and confidence to provide behaviour management to support children of differing ages and stages of development. It is not surprising then that dental students find treating children especially stressful. Paediatric dentistry training is therefore a vital element of the undergraduate dental curriculum. MATERIALS AND METHODS: Eighty-six fourth-year undergraduate dental students received standard lectures and seminars about behaviour management techniques for children having local anaesthetic...
February 27, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28239640/serum-il-8-is-a-marker-of-white-matter-hyperintensities-in-patients-with-alzheimer-s-disease
#3
Yanan Zhu, Yuek Ling Chai, Saima Hilal, M Kamran Ikram, Narayanaswamy Venketasubramanian, Boon-Seng Wong, Christopher P Chen, Mitchell K P Lai
INTRODUCTION: Neuroinflammation and cerebrovascular disease (CeVD) have been implicated in cognitive impairment and Alzheimer's disease (AD). The present study aimed to examine serum inflammatory markers in preclinical stages of dementia and in AD, as well as to investigate their associations with concomitant CeVD. METHODS: We performed a cross-sectional case-control study including 96 AD, 140 cognitively impaired no dementia (CIND), and 79 noncognitively impaired participants...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28239578/nasopharyngeal-angiofibroma-paradigm-shift-in-management
#4
Manzoor Ahmad Latoo, Waqar Ul Hamid, Aleena Shafi Jallu, Mudasir Ul Islam, Rafiq Ahmad Pampori
To report on a series of patients of nasopharyngeal angiofibroma of varied ages with different stages and management algorithm which reduced morbidity associated with this tumour. Retrospective. We report a series of ten patients who presented to a tertiary care institution and were diagnosed to have NA from 2012 to 2014. Patients were categorized by Radkowski staging and data was collected to document differences in terms of presentation, operative technique, and postoperative course. All patients underwent preoperative embolization...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28239415/coupling-gene-regulatory-patterns-to-bioprocess-conditions-to-optimize-synthetic-metabolic-modules-for-improved-sesquiterpene-production-in-yeast
#5
Bingyin Peng, Manuel R Plan, Alexander Carpenter, Lars K Nielsen, Claudia E Vickers
BACKGROUND: Assembly of heterologous metabolic pathways is commonly required to generate microbial cell factories for industrial production of both commodity chemicals (including biofuels) and high-value chemicals. Promoter-mediated transcriptional regulation coordinates the expression of the individual components of these heterologous pathways. Expression patterns vary during culture as conditions change, and this can influence yeast physiology and productivity in both positive and negative ways...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28239396/the-prognostic-value-of-baseline-lymphocyte-neutrophil-and-monocyte-counts-in-locally-advanced-cervical-carcinoma-treated-with-radiation
#6
Sareena Singh, Justin Himler, Christa I Nagel, Kimberly Resnick
Background. To determine the prognostic significance of pretreatment levels of circulating lymphocyte (CLC), neutrophil (CNC), and monocyte (CMC) counts in patients with locally advanced cervical carcinoma (CC) treated with definitive radiation. Methods. A retrospective, dual-institution review of patients with Stage IB2-IVA CC from 2005 to 2015. Progression-free (PFS) and Overall Survival (OS) were determined for high and low CLC, CNC, and CMC groups. Multivariate analysis was used to confirm prognostic value of baseline leukocyte counts...
2017: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28239180/clinical-and-demographic-predictors-of-conversion-to-dementia-in-mexican-elderly-with-mild-cognitive-impairment
#7
Sara G Aguilar-Navarro, Alberto J Mimenza-Alvarado, José Alberto Ávila-Funes, Teresa Juárez-Cedillo, Carolina Bernal-López, Celia G Hernández-Favela
BACKGROUND: Mild cognitive impairment (MCI) is considered a clinical stage between normal cognitive aging and dementia. The clinical course of MCI is heterogeneous, with a significant number of cases progressing to dementia or reverting back to normal. OBJECTIVE: To determine the predictors of conversion from mild cognitive impairment to dementia among Mexican older adults. MATERIALS AND METHODS: A sample of 175 persons underwent clinical and neuropsychological evaluation to establish mild cognitive impairment diagnosis...
January 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28238919/characteristics-management-and-outcomes-of-surgically-treated-arteriovenous-fistula-aneurysm-in-patients-on-regular-hemodialysis
#8
Hassan Al-Thani, Ayman El-Menyar, Noora Al-Thani, Mohammad Asim, Ahmed Hussein, Ahmed Sadek, Ahmed Sharaf, Amr Fares
BACKGROUND: To investigate the clinical characteristics, surgical interventions and outcomes of arteriovenous fistula (AVF) aneurysms, we retrospectively analyzed patients on regular hemodialysis (HD). METHODS: We conducted a cohort study of all patients with HD access who presented with AVF aneurysms and underwent operative procedures over a 11-year period. Patients' demographics, comorbidities, vascular access characteristics, management of aneurysms, complications and outcomes were analyzed...
February 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28238593/her2-enriched-subtype-as-a-predictor-of-pathological-complete-response-following-trastuzumab-and-lapatinib-without-chemotherapy-in-early-stage-her2-positive-breast-cancer-pamela-an-open-label-single-group-multicentre-phase-2-trial
#9
Antonio Llombart-Cussac, Javier Cortés, Laia Paré, Patricia Galván, Begoña Bermejo, Noelia Martínez, Maria Vidal, Sònia Pernas, Rafael López, Montserrat Muñoz, Paolo Nuciforo, Serafín Morales, Mafalda Oliveira, Lorena de la Peña, Alexandra Peláez, Aleix Prat
BACKGROUND: HER2-positive breast cancer consists of four intrinsic molecular subtypes-luminal A, luminal B, HER2-enriched, and basal-like-and a normal-like subtype, with the HER2-enriched subtype having the highest activation of the EGFR-HER2 pathway. We aimed to test the hypothesis that patients with the HER2-enriched subtype benefit the most from dual HER2 blockade. METHODS: PAMELA is an open-label, single-group, phase 2 trial done in 19 hospitals in Spain. We recruited female patients aged at least 18 years with previously untreated, centrally confirmed HER2-positive, stage I-IIIA invasive breast cancer regardless of hormone receptor status...
February 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28238592/frequency-of-carcinoid-syndrome-at-neuroendocrine-tumour-diagnosis-a-population-based-study
#10
Daniel M Halperin, Chan Shen, Arvind Dasari, Ying Xu, Yiyi Chu, Shouhao Zhou, Ya-Chen Tina Shih, James C Yao
BACKGROUND: Neuroendocrine tumours (NETs) can secrete bioactive amines into the bloodstream, causing carcinoid syndrome, with symptoms including flushing and diarrhoea. However, carcinoid syndrome frequency in the NET population has never been rigorously assessed, nor has its relationship to presenting clinicopathological characteristics. This analysis assessed the proportion of patients with NETs and carcinoid syndrome in the USA and associated clinical factors. METHODS: We identified patients (≥65 years of age) from the Surveillance, Epidemiology, and End Results-Medicare database, excluding those with pancreatic tumours or small-cell or large-cell lung cancer, as well as those without complete data...
February 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28238527/interferon-alpha-impairs-insulin-production-in-human-beta-cells-via-endoplasmic-reticulum-stress
#11
Angela Lombardi, Yaron Tomer
Despite substantial advances in the research exploring the pathogenesis of Type 1 Diabetes (T1D), the pathophysiological mechanisms involved remain unknown. We hypothesized in this study that interferon alpha (IFNα) participates in the early stages of T1D development by triggering endoplasmic reticulum (ER) stress. To verify our hypothesis, human islets and human EndoC-βH1 cells were exposed to IFNα and tested for ER stress markers, glucose stimulated insulin secretion (GSIS) and insulin content. IFNα treatment induced upregulation of ER stress markers including Binding immunoglobulin Protein, phospho-eukaryotic translation initiation factor 2α, spliced- X-box binding protein-1, C/EBP homologous protein and activating transcription factor 4...
February 23, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28238444/pet-ct-in-presurgical-lymph-node-staging-in-non-small-cell-lung-cancer-the-importance-of-false-negative-and-false-positive-findings
#12
A Bustos García de Castro, J Ferreirós Domínguez, R Delgado Bolton, C Fernández Pérez, B Cabeza Martínez, M García García-Esquinas, J L Carreras Delgado
OBJECTIVE: To assess the importance of false-negative and false-positive findings in computed tomography (CT) and (18)F-FDG positron emission tomography (PET) in mediastinal lymph node staging in patients undergoing surgery for non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: This retrospective study included 113 consecutive patients and 120 resected NSCLCs; 22 patients received neoadjuvant treatment. We compared the findings on preoperative (18)F-FDG PET-CT studies with the postoperative pathology findings...
February 23, 2017: Radiología
https://www.readbyqxmd.com/read/28238354/optimal-primary-management-of-bulky-stage-iiic-ovarian-fallopian-tube-and-peritoneal-carcinoma-are-the-only-options-complete-gross-resection-at-primary-debulking-surgery-or-neoadjuvant-chemotherapy
#13
Vasileios D Sioulas, Maria B Schiavone, David Kadouri, Oliver Zivanovic, Kara Long Roche, Roisin O'Cearbhaill, Nadeem R Abu-Rustum, Douglas A Levine, Yukio Sonoda, Ginger J Gardner, Mario M Leitao, Dennis S Chi
OBJECTIVE: To explore the impact of primary debulking surgery (PDS) to minimal but gross residual disease (RD) in women with bulky stage IIIC ovarian, fallopian tube, or primary peritoneal cancer. METHODS: We retrospectively reviewed all patients with the aforementioned diagnosis who underwent PDS at our institution from 01/2001-12/2010. Those with disease of non-epithelial histology or borderline tumors were excluded. Clinicopathologic data were abstracted, and appropriate statistical tests were used...
February 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28238284/native-t1-mapping-inter-study-inter-observer-and-inter-center-reproducibility-in-hemodialysis-patients
#14
Matthew P M Graham-Brown, Elaine Rutherford, E Levelt, Daniel S March, Darren R Churchward, David J Stensel, Christie McComb, Kenneth Mangion, Samantha Cockburn, Colin Berry, James C Moon, Patrick B Mark, James O Burton, Gerry P McCann
BACKGROUND: Native T1 mapping is a cardiovascular magnetic resonance (CMR) technique that associates with markers of fibrosis and strain in hemodialysis patients. The reproducibility of T1 mapping in hemodialysis patients, prone to changes in fluid status, is unknown. Accurate quantification of myocardial fibrosis in this population has prognostic potential. METHODS: Using 3 Tesla CMR, we report the results of 1) the inter-study, inter-observer and intra-observer reproducibility of native T1 mapping in 10 hemodialysis patients; 2) inter-study reproducibility of left ventricular (LV) structure and function in 10 hemodialysis patients; 3) the agreement of native T1 map and native T1 phantom analyses between two centres in 20 hemodialysis patients; 4) the effect of changes in markers of fluid status on native T1 values in 10 hemodialysis patients...
February 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28238223/glucose-lowering-agents-for-treating-pre-existing-and-new-onset-diabetes-in-kidney-transplant-recipients
#15
REVIEW
Clement Lo, Min Jun, Sunil V Badve, Helen Pilmore, Sarah L White, Carmel Hawley, Alan Cass, Vlado Perkovic, Sophia Zoungas
BACKGROUND: Kidney transplantation is the preferred form of kidney replacement therapy for patients with end-stage kidney disease (ESKD) and is often complicated by worsening or new-onset diabetes. Management of hyperglycaemia is important to reduce post-transplant and diabetes-related complications. The safety and efficacy of glucose-lowering agents after kidney transplantation is largely unknown. OBJECTIVES: To evaluate the efficacy and safety of pharmacological interventions for lowering glucose levels in patients who have undergone kidney transplantation and have diabetes...
February 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28238216/impact-of-a-restrictive-versus-liberal-transfusion-strategy-on-anastomotic-leakage-and-infectious-complications-after-restorative-surgery-for-rectal-cancer
#16
Volkan Ozben, Luca Stocchi, Jean Ashburn, Xiaobo Liu, Emre Gorgun
AIM: The aim of this study was to investigate the impact of restrictive versus liberal transfusion strategy on anastomotic leakage and infectious complications after rectal cancer surgery. METHODS: Patients undergoing restorative proctectomy for rectal cancer between 01/2008 and 12/2013 were divided into four groups according to the perioperative lowest haemoglobin (Hgb) level and transfusion status: Group 1 with Hgb level ≥10 g/dL, Group 2 ≥7 and <10 g/dL, who did not receive transfusion, and Group 3 with Hgb level ≥7 and <10 g/dL and Group 4 <7 g/dL, both of which received a transfusion...
February 26, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28238212/development-a-rapid-and-accurate-multiplex-real-time-pcr-method-for-the-detection-chlamydia-trachomatis-and-mycoplasma-hominis
#17
Roya Safarkar, Jalil Fallah Mehrabadi, Zahra Noormohammadi, Reza Mirnejad
BACKGROUND: Sexually transmitted diseases easily spread among sexually active people and often have no symptoms. Rapid and accurate method for detecting these infections are necessary in early stages. The traditional detection methods of them are difficult and time-consuming. METHODS: In this study, multiplex real time PCR was optimized for rapid identification of Chlamydia trachomatis and Mycoplasma hominis in a single tube and was performed with our designed primers...
February 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28238148/long-term-cancer-control-outcomes-of-robot-assisted-radical-prostatectomy-for-prostate-cancer-treatment-a-meta-analysis
#18
Lei Wang, Baojun Wang, Qing Ai, Yu Zhang, Xiangjun Lv, Hongzhao Li, Xin Ma, Xu Zhang
PURPOSE: Robot-assisted radical prostatectomy (RARP) provides significant advantages in short-term oncological outcomes for prostate cancer patients. However, data regarding the long-term cancer control outcomes of RARP are limited and inconsistent. This study aimed to evaluate these long-term outcomes. METHODS: Medline, Scopus, and other databases were searched for studies published from January 2010 to July 2016. Case series and prospective cohort studies on the long-term cancer control outcomes of patients who underwent RARP were subjected to meta-analyses by using the R statistical software...
February 25, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28238064/hepatic-inflammation-fibrosis-cancer-axis-in-the-rat-hepatocellular-carcinoma-induced-by-diethylnitrosamine
#19
Yong-Fang Ding, Zhen-Hui Wu, Ying-Jie Wei, Luan Shu, Yun-Ru Peng
PURPOSE: Hepatocellular carcinoma (HCC) cases are closely associated with chronic inflammation and fibrosis which is known as hepatic inflammation-fibrosis-cancer (IFC) axis. The aim of this study is to elucidate the development characteristics of the rat HCC model based on IFC axis. METHODS: The diethylnitrosamine (DEN)-induced rat HCC, which presents a stepwise histopathological progression that is similar to human HCC, was used to analyze the features of the different stages (inflammation, fibrosis, cancer)...
February 25, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28238033/clinical-and-multiparametric-mri-signatures-of-granulomatous-prostatitis
#20
Soroush Rais-Bahrami, Jeffrey W Nix, Baris Turkbey, Jason A Pietryga, Rupan Sanyal, John V Thomas, Jennifer B Gordetsky
PURPOSE: The purpose of the study is to differentiate granulomatous prostatitis (GP) from high-grade prostate cancer (PCa) based on clinical findings and imaging characteristics on multiparametric MRI (MP-MRI). METHODS: Pathology from patients undergoing MRI/US fusion-guided prostate biopsies between 2014 and 2015 was reviewed. Five patients with biopsy proven GP were identified as well as 15 patients with biopsy-proven Gleason score ≥4 + 3 = 7 PCa. Patients were matched for age, serum PSA level, and prebiopsy-assigned MP-MRI cancer suspicion scores...
February 25, 2017: Abdominal Radiology
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