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https://www.readbyqxmd.com/read/28738669/evaluation-of-the-effectiveness-of-a-transfer-interhemispheric-training-programme-in-the-early-stages-of-fencing-training
#1
Mateusz Witkowski, Michał Bronikowski, Agnieszka Nowik, Maciej Tomczak, Jan Strugarek
BACKGROUND: A high level of motor coordination (with an emphasis on the accuracy of hand movements) is an important part of fencers' training. Research on motor coordination shows that both hemispheres of the brain are involved in controlling the action of each of the upper limbs. As the physical training of one hand is believed to significantly increase the performance of the other (untrained) hand [14], the authors attempt to verify the hypothesis that specialized training of the nondominant limb can improve the performance of the dominant hand in fencing...
July 24, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28738491/-establishment-of-a-model-of-hydrogen-peroxide-induced-injury-in-pulmonary-artery-endothelium-cells-and-relevant-mechanisms-of-oxidative-stress
#2
J Ye, Y Y He, Y Yan, J H Zhao, T Y Lian, X J Wang, Y Yan, S J Zhang, S H Yang, Z C Jing
Objective: To establish a hydrogen peroxide (H(2)O(2)) induced injury model of pulmonary artery endothelial cells (PAECs) and explore the molecular mechanisms of oxidative stress on the structure and function of PAECs in this model. Methods: Human PAECs were treated with H(2)O(2) at different concentrations (25, 50, 100, 200, 400, 800, 1 600, 3 200, 6 400 μmol/L) for 4 and 24 h, respectively. The PAECs survival curve was obtained according to the cell viability measured by CCK-8 assay. The cell apoptosis of PAECs was detected by flow cytometry...
July 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28738463/-a-cross-sectional-study-on-dyslipidemia-in-migrants-in-inner-mongolia-autonomous-region
#3
T Zhang, Q Zhou, Y G Qian, J Zhou, S J Wu, P Y Wang, A P Liu
Objective: To investigate the prevalence of dyslipidemia in migrants in Inner Mongolia Autonomous Region. Methods: A stratified multi-stage cluster equal size sampling was performed among the migrants aged ≥18 years who were engaged in manufacturing, wholesale retail, accommodation and catering service, social service, construction and other and 1 501 migrants from five area in Inner Mongolia Autonomous Region was investigated by means of questionnaires survey, physical measurements and laboratory detection...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738459/-gene-gene-interaction-on-central-obesity-in-school-aged-children-in-china
#4
L W Fu, M X Zhang, L J Wu, L W Gao, J Mi
Objective: To investigate possible effect of 6 obesity-associated SNPs in contribution to central obesity and examine whether there is an interaction in the 6 SNPs in the cause of central obesity in school-aged children in China. Methods: A total of 3 502 school-aged children who were included in Beijing Child and Adolescent Metabolic Syndrome (BCAMS) Study were selected, and based on the age and sex specific waist circumference (WC) standards in the BCAMS study, 1 196 central obese cases and 2 306 controls were identified...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738338/cognitive-impairment-is-reflected-by-an-increased-difference-between-real-and-imagined-timed-up-and-go-test-performance
#5
Stefanie Rüdiger, Tim Stuckenschneider, Tobias Vogt, Vera Abeln, Brian Lawlor, Marcel Olde Rikkert, Stefan Schneider
BACKGROUND: Recent research suggests using an imaginary version of the Timed Up and Go test (TUG) for a first assessment of cognitive impairment. By using the time difference between a real (TUGr) and an imagined (TUGi) TUG task, the objective of this study was to examine the effect of cognitive impairment on motor imagery ability. METHODS: Fifty-two participants (mean age 69.3 ± 4.0 years) with mild cognitive impairment or subjective cognitive impairment were included in this study...
July 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28738297/endometrial-stromal-sarcoma-a-retropsective-analysis-of-factors-affecting-recurrence
#6
Reshu Agarwal, Anupama Rajanbabu, Indu R Nair, Chandramouli Satish, Georgeena Jose, U G Unikrishnan
OBJECTIVE: To assess the factors associated with disease free survival and overall survival in endometrial stromal sarcoma (ESS). METHODS: This was a single institution retrospective analysis done at Amrita Institute of Medical Sciences. Records from January 2005 to October 2016 were analysed and 42 patients with ESS were identified. Clinicopathological, surgical management, adjuvant treatment and outcome data were collected. Disease free and overall survivals were analysed using Kaplan-Meier method and compared using log rank test...
July 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28738214/plasmodium-falciparum-in%C3%A2-vitro-continuous-culture-conditions-a-comparison-of-parasite-susceptibility-and-tolerance-to-anti-malarial-drugs-throughout-the-asexual-intra-erythrocytic-life-cycle
#7
Sandra Duffy, Vicky M Avery
The continuous culture of Plasmodium falciparum is often seen as a means to an end, that end being to probe the biology of the parasite in question, and ultimately for many in the malaria drug discovery arena, to identify means of killing the parasite in order to treat malaria. In vitro continuous culture of Plasmodium falciparum is a fundamental requirement when undertaking malaria research where the primary objectives utilise viable parasites of a desired lifecycle stage. This investigation, and resulting data, compared the impact culturing Plasmodium falciparum long term (4 months) in different environmental conditions had on experimental outcomes and thus conclusions...
July 15, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28737620/sarcoidosis-following-anti-pd-1-and-anti-ctla-4-therapy-for-metastatic-melanoma
#8
Swathi B Reddy, Jennifer D Possick, Harriet M Kluger, Anjela Galan, Dale Han
Immune checkpoint inhibitors represent the newest treatment for stage IV melanoma. These agents are generally well tolerated, however severe immune-related adverse effects have been noted in a small, but clinically significant percentage of patients. Specifically, sarcoidosis is a known potential complication following anti-CTLA-4 therapy. We present 2 cases of pulmonary and cutaneous sarcoidosis developing in patients with stage IV melanoma. Both patients were treated with ipilimumab and anti-PD-1 therapy, and both experienced good oncologic responses to treatment; neither had evidence of preexisting sarcoidosis...
July 21, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28737450/initial-characterization-of-the-growth-stimulation-and-heat-shock-induced-adaptive-response-in-developing-lake-whitefish-embryos-after-ionizing-radiation-exposure
#9
Christopher Thome, Charles Mitz, Emily N Hulley, Christopher M Somers, Richard G Manzon, Joanna Y Wilson, Douglas R Boreham
Ionizing radiation is known to effect development during early life stages. Lake whitefish (Coregonus clupeaformis) represent a unique model organism for examining such effects. The purpose of this study was to examine how ionizing radiation affects development in lake whitefish embryos and to investigate the presence of an adaptive response induced by heat shock. Acute exposure to (137)Cs gamma rays was administered at five time points corresponding to major developmental stages, with doses ranging from 0...
July 24, 2017: Radiation Research
https://www.readbyqxmd.com/read/28737220/current-state-of-pharmacovigilance-in-the-arab-and-eastern-mediterranean-region-results-of-a-2015-survey
#10
Danya M Qato
OBJECTIVES: This study describes the current state of pharmacovigilance systems in Arab and Eastern Mediterranean countries. METHODS: A descriptive cross-sectional study was conducted between May and September 2015. Data were gathered from a standardized online survey sent to pharmacovigilance leadership identified as the official national contact for the WHO Programme for International Drug Monitoring. In countries with no specified pharmacovigilance programme or leadership, Ministry of Health officers responsible for drug safety policies were invited to participate in the survey...
July 24, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28737154/effect-of-dose-and-frequency-of-exposure-to-infectious-stages-on-trematode-infection-intensity-and-success-in-mussels
#11
Caroline Liddell, Jennifer E Welsh, Jaap van der Meer, David W Thieltges
Marine parasites such as trematodes often compromise the fitness of their hosts. Such effects are generally considered to be density-dependent, i.e. the greater the infection intensity in the host, the greater the detrimental impact on host fitness. However, the mechanisms determining infection in marine hosts are still poorly understood. Here, we investigated the effect of cercarial dose and exposure frequency (single vs. trickle infections) of a marine trematode parasite, Himasthla elongata (Trematoda: Echinostomatidae), on infection intensity and success in its second intermediate host, the blue mussel Mytilus edulis, an abundant and widely distributed bivalve in European coastal waters...
July 24, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28736952/validation-of-the-albi-grade-based-integrated-model-as-a-predictor-for-sorafenib-failed-hepatocellular-carcinoma
#12
Pei-Chang Lee, Yi-Tzen Chen, Yee Chao, Teh-Ia Huo, Chung-Pin Li, Chien-Wei Su, Mei-Hsuan Lee, Ming-Chih Hou, Fa-Yauh Lee, Han-Chieh Lin, Yi-Hsiang Huang
BACKGROUND AND AIMS: Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC) but is challenging after treatment failure. Appropriate criteria for enrolling patients into second-line trials are still limited. In this study, we aimed to establish more objective criteria based on Albumin-Bilirubin (ALBI) grade to select patients with better post-progression survival (PPS) for second-line treatment. METHODS: Consecutive 404 advanced HCC patients receiving sorafenib were retrospectively enrolled...
July 24, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28736847/reproductive-plasticity-and-landscape-heterogeneity-benefit-a-ground-nesting-bird-in-a-fire-prone-ecosystem
#13
J Matthew Carroll, Torre J Hovick, Craig A Davis, R Dwayne Elmore, Samuel D Fuhlendorf
Disturbance is critical for the conservation of rangeland ecosystems worldwide and many of these systems are fire dependent. Although it is well established that restoring fire as an ecological process can lead to increased biodiversity in grasslands and shrublands, the underlying mechanisms driving community patterns are poorly understood for fauna in fire-prone landscapes. Much of this uncertainty stems from the paucity of studies that examine the effects of fire at scales relevant to organism life histories...
July 24, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28736676/label-free-photoacoustic-imaging-of-the-cardio-cerebrovascular-development-in-the-embryonic-zebrafish
#14
Qian Chen, Tian Jin, Weizhi Qi, Xianming Mo, Lei Xi
Zebrafish play an important role in biology, pharmacology, toxicology, and medicine. The cardio-cerebrovascular development of zebrafish is particularly critical to understand both brain disorders and cardiovascular diseases in human. In this paper, we applied optical resolution photoacoustic microscopy (ORPAM) to image the whole-body vasculature of the embryonic zebrafish with a special focus on the development of the cardio-cerebrovascular system. Using the intrinsic optical absorption contrast of the embryo, we successfully visualized the formation of the cardio-cerebrovascular network in high-resolution using a 10 × objective, and monitored the whole-body vascular development using a 4 × objective...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28736561/recent-advances-in-stroke-prevention-in-patients-with-atrial-fibrillation-and-end-stage-renal-disease
#15
REVIEW
Federico Ronco, Patrizio Mazzone, Leila Hosseinian, Simonetta Genovesi
BACKGROUND: Chronic kidney disease (CKD) is associated with a high prevalence of atrial fibrillation (AF), but in this population the risk/benefit ratio of anticoagulant therapy with vitamin K antagonists (VKA) for thromboprophylaxis is uncertain. SUMMARY: In end-stage renal disease (ESRD) patients undergoing hemodialysis, VKA seem less effective in stroke prevention than in the general population, with an increased risk of major bleeding. Recently, novel oral anticoagulant agents (NOACs) have proven to be effective for stroke prevention in AF and have demonstrated an improved safety profile compared to VKA...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736363/-clinical-characteristics-and-risk-factors-affecting-outcomes-of-elderly-patients-with-non-small-cell-lung-cancer-complicated-by-chronic-obstructive-pulmonary-disease
#16
Peng Wang, Dong Zhang, Xue-Guang Guo, Bao-Jun Sun, Xiang-Qun Fang, Ge-Ping Qu, Chang-Ting Liu
OBJECTIVE: To investigate the clinical features, treatment strategy and risk factors affecting the prognosis of elderly patients with non-small cell lung cancer (NSCLC) complicated by chronic obstructive pulmonary disease (COPD). METHODS: We retrospectively analyzed the data of elderly patietns (>60 years) with newly diagnosed NSCLC complicated by COPD at the Geriatric Institution of General Hospital of PLA between January, 2000 and June, 2015. The clinical data collected included history of smoking, pulmonary function test results, initial treatments, TNM stage, chief complaints, comorbidities and laboratory tests...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28736322/clinical-outcomes-of-chemotherapy-na%C3%A3-ve-men-with-metastatic-castration-resistant-prostate-cancer-and-low-baseline-psa-treated-with-enzalutamide-vs-placebo
#17
Mary-Ellen Taplin, Andrew J Armstrong, Ping Lin, Andrew Krivoshik, De Phung, Teresa Parli, Bertrand Tombal, Tomasz M Beer
PURPOSE: Metastatic castration-resistant prostate cancer with low baseline prostate-specific antigen represents an early stage in the natural history of castration-resistant prostate cancer disease progression (low-volume disease), low prostate-specific antigen-producing disease, or disease less dependent on androgen receptor biology (high-volume disease). We analyzed outcomes in men with low prostate-specific antigen and high disease burden who received the oral androgen-receptor inhibitor enzalutamide in the PREVAIL study...
July 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28736309/neural-interactions-mediating-conflict-control-and-its-training-induced-plasticity
#18
Min Hu, Xiangpeng Wang, Wenwen Zhang, Xueping Hu, Antao Chen
Cognitive control is of great plasticity. Training programs targeted on improving it have been suggested to yield neural changes in the brain. However, until recently, the relationship between training-induced brain changes and improvements in cognitive control is still an open issue. Besides, although the literature has attributed the operation of cognitive control to interactions between large-scale networks, the neural pathways directly associated with it remain unclear. The current study aimed to examine these issues by focusing on conflict processing...
July 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28736250/change-in-prostate-cancer-presentation-coinciding-with-uspstf-screening-recommendations-at-a-community-based-urology-practice
#19
Franklin D Gaylis, Jae E Choi, Zachary Hamilton, Paul Dato, Edward Cohen, Renee Calabrese, Hilary Prime, Aaron Rosenbaum, Andrew Karim Kader
OBJECTIVE: The benefits of prostate-specific antigen (PSA)-based prostate cancer screening are controversial. We sought to determine the change in prostate cancer presentation coinciding with the release of the United States Preventative Services Task Force recommendations against screening in a high-volume community-based urology practice. METHODS: Characteristics of men presenting for an elevated PSA at a community urology practice from August 2011 to August 2015 were queried from a prospectively collected database...
July 20, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28736232/stage-specific-embryonic-antigen-4-ssea-4-as-a-distinguishing-marker-between-eccrine-and-apocrine-origin-of-ducts-of-sweat-glands
#20
Julia Borowczyk-Michalowska, Eliza Zimolag, Piotr Konieczny, Anna Chrapusta, Zbigniew Madeja, Justyna Drukala
No abstract text is available yet for this article.
July 20, 2017: Journal of Investigative Dermatology
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