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Cysticercosis

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https://www.readbyqxmd.com/read/29026624/first-case-of-human-peritoneal-cysticercosis-mimicking-peritoneal-carcinosis-necessity-of-laparoscopy-and-histologic-assessment-for-the-correct-diagnosis
#1
Martina Rudelius, Klaus Brehm, Martin Poelcher, Christoph Spinner, Andreas Rosenwald, Clarissa Prazeres da Costa
Introduction. Correct diagnosis of peritoneal infectious disease can be extremely difficult due to non-specific clinical features. Thus, careful assessment with thorough histopathological work-up is essential. Here, we report the first case of human peritoneal cysticercosis mimicking peritoneal carcinosis. Case presentation. The patient presented with recurring ascites and a tumour in the Douglas cavity accompanied by elevated tumour markers. There were no signs of systemic infection. On laparoscopy, the tumour was resected completely...
June 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29020381/antibody-banding-patterns-of-the-enzyme-linked-immunoelectrotransfer-blot-eitb-and-brain-imaging-findings-in-patients-with-neurocysticercosis
#2
Gianfranco Arroyo, Silvia Rodriguez, Andres G Lescano, Karen Alroy, Javier A Bustos, Saul Santivañez, Isidro Gonzales, Herbert Saavedra, E Javier Pretell, Armando E Gonzalez, Robert H Gilman, Victor C W Tsang, Hector H Garcia
Background: The enzyme-linked immunoelectrotransfer blot (EITB) assay is the reference serological test for neurocysticercosis (NCC). A positive result on EITB does not always correlate with the presence of active infections in the central nervous system (CNS), and patients with a single viable brain cyst may be EITB negative. Nonetheless, EITB antibody banding patterns appears to be related with the expression of three protein families of Taenia solium, and in turn with the characteristics of NCC in the CNS (type, stage and burden of viable cysts)...
September 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016332/porcine-cysticercosis-possible-cross-reactivity-of-taenia-hydatigena-to-gp50-antigen-in-the-enzyme-linked-immunoelectrotransfer-blot-assay
#3
Claudio Muro, Luis A Gomez-Puerta, Robert H Flecker, Ricardo Gamboa, Percy Vilchez Barreto, Pierre Dorny, Victor C W Tsang, Robert H Gilman, Armando E Gonzalez, Hector H Garcia Lescano, Seth E O'Neal, For The Cysticercosis Working Group In Peru
The lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites have been evaluated for cross reactivity. Pigs may host other related cestode infections, including Taenia hydatigena, which have not been formally evaluated for cross-reactions. We investigated a corral in Tumbes, Peru, a region where a cysticercosis elimination demonstration project was completed in 2012...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29016298/case-report-cysticercosis-sonographic-diagnosis-of-a-treatable-cause-of-epilepsy-and-skin-nodules
#4
Tom Heller, Claudia Wallrauch, Daniel Kaminstein, Sam Phiri
A case of disseminated cysticercosis of brain, muscle subcutaneous tissue is reported and the use of musculoskeletal ultrasound in the diagnosis of the condition emphasized.
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994510/isolated-lingual-cysticercosis-a-rare-case-diagnosed-on-cytology
#5
Mukta Pujani, Mohd Jaseem Hassan, Sabina Khan, Sujata Jetley
Cysticercosis is caused by larval stage of Taenia solium called cysticercus cellulosae. Cysticercosis most commonly infects skeletal muscles, subcutaneous tissues, brain and ocular tissue. On extensive search of literature, only around 64 cases of lingual cysticercosis have been reported till date. We report a case of cysticercosis of tongue in a 35-year-old male who presented with a painless, slowly growing swelling over the lateral border of tongue. Fine needle aspiration cytology revealed wavy integument of cysticercus cellulosae alongwith inflammatory cells...
October 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28969835/serological-diagnosis-of-taenia-solium-in-pigs-no-measurable-circulating-antigens-and-antibody-response-following-exposure-to-taenia-saginata-oncospheres
#6
P Dorny, V Dermauw, A Van Hul, C Trevisan, S Gabriël
Taenia solium taeniasis/cysticercosis is a zoonosis included in the WHO's list of neglected tropical diseases. Accurate diagnostic tools for humans and pigs are needed to monitor intervention outcomes. Currently used diagnostic tools for porcine cysticercosis all have drawbacks. Serological tests are mainly confronted with problems of specificity. More specifically, circulating antigen detecting tests cross-react with Taenia hydatigena and the possibility of transient antigens as a result of aborted infections is suspected...
October 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28955045/effect-of-transforming-growth-factor-%C3%AE-upon-taenia-solium-and-taenia-crassiceps-cysticerci
#7
Laura Adalid-Peralta, Gabriela Rosas, Asiel Arce-Sillas, Raúl J Bobes, Graciela Cárdenas, Marisela Hernández, Celeste Trejo, Gabriela Meneses, Beatriz Hernández, Karel Estrada, Agnes Fleury, Juan P Laclette, Carlos Larralde, Edda Sciutto, Gladis Fragoso
Taeniids exhibit a great adaptive plasticity, which facilitates their establishment, growth, and reproduction in a hostile inflammatory microenvironment. Transforming Growth Factor-β (TGFβ), a highly pleiotropic cytokine, plays a critical role in vertebrate morphogenesis, cell differentiation, reproduction, and immune suppression. TGFβ is secreted by host cells in sites lodging parasites. The role of TGFβ in the outcome of T. solium and T. crassiceps cysticercosis is herein explored. Homologues of the TGFβ family receptors (TsRI and TsRII) and several members of the TGFβ downstream signal transduction pathway were found in T...
September 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28945737/quantitative-multiplexed-proteomics-of-taenia-solium-cysts-obtained-from-the-skeletal-muscle-and-central-nervous-system-of-pigs
#8
José Navarrete-Perea, Marta Isasa, Joao A Paulo, Ricardo Corral-Corral, Jeanette Flores-Bautista, Beatriz Hernández-Téllez, Raúl J Bobes, Gladis Fragoso, Edda Sciutto, Xavier Soberón, Steven P Gygi, Juan P Laclette
In human and porcine cysticercosis caused by the tapeworm Taenia solium, the larval stage (cysts) can infest several tissues including the central nervous system (CNS) and the skeletal muscles (SM). The cyst's proteomics changes associated with the tissue localization in the host tissues have been poorly studied. Quantitative multiplexed proteomics has the power to evaluate global proteome changes in response to different conditions. Here, using a TMT-multiplexed strategy we identified and quantified over 4,200 proteins in cysts obtained from the SM and CNS of pigs, of which 891 were host proteins...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28932584/two-cases-of-pulmonary-cysticercosis-manifesting-as-pleural-effusion-case-report-and-literature-review
#9
Youfei Chen, Pingli Wang, Liren Ding
Cysticercosis is an important public health problem in developing countries. The major involvement sites are the central nervous system and the eyes, although striated muscles and subcutaneous tissues are frequently involved in the disseminated form of disease. Pulmonary involvement in cysticercosis is very rare and ill-defined nodular shadows distributed throughout the lung is the usual radiological presentation. Only one case of cysticercosis presenting as lung cavity with pleural effusion has been reported so far in literature...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932037/fine-needle-aspiration-cytology-of-cysticercosis-in-submandibular-gland
#10
Vaneet Kaur Sandhu, Upender Sharma, Navtej Singh, Geetika Goyal
Fine-needle aspiration cytology (FNAC) has emerged as simple, minimally invasive, low-cost, outpatient diagnostic modality for the evaluation of nodules caused by parasites. Cysticercosis is caused by larval stage of Taenia solium, pork tapeworm. It is endemic in Southeast Asia, Latin America and South Africa. We report a case of cysticercosis in a 25-year-old male who presented with painless swelling of submandibular gland which was diagnosed on FNAC. The patient was recommended antihelminthic therapy which resulted in complete resolution of the swelling...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28923896/experimental-and-theoretical-approaches-to-investigate-the-immunogenicity-of-taenia-solium-derived-ke7-antigen
#11
Raúl J Bobes, José Navarrete-Perea, Adrián Ochoa-Leyva, Víctor Hugo Anaya, Marisela Hernández, Jacquelynne Cervantes-Torres, Karel Estrada, Filiberto Sánchez-Lopez, Xavier Soberón, Gabriela Rosas, Cáris Maroni Nunes, Martín García-Varela, Rogerio Rafael Sotelo-Mundo, Alonso Alexis López-Zavala, Goar Gevorkian, Gonzalo Acero, Juan P Laclette, Gladis Fragoso, Edda Sciutto
Taenia solium cysticercosis, a parasitic disease that affects human health in various regions of the world, is preventable by vaccination. Both the 97-amino-acid-long KETc7 peptide and its carboxyl-terminal, 18-amino-acid-long sequence (GK-1) are found in Taenia crassiceps Both peptides, with proven protective capacity against cysticercosis, are part of the highly conserved, cestode-native, 264-amino-acid long protein KE7. KE7 belongs to a ubiquitously distributed family of proteins associated to membrane processes and may participate in several vital cell pathways...
September 18, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28923090/mapping-occurrence-of-taenia-solium-taeniosis-cysticercosis-and-areas-at-risk-of-porcine-cysticercosis-in-central-america-and-the-caribbean-basin
#12
Uffe Christian Braae, Brecht Devleesschauwer, Fortune Sithole, Ziqi Wang, Arve Lee Willingham
BACKGROUND: This study aimed to map the occurrence of Taenia solium taeniosis/cysticercosis at national level within Central America and the Caribbean basin, and to map the distribution of porcine cysticercosis at first-level administrative subdivision level (department level) and the porcine population at risk. This zoonotic parasite is believed to be widely endemic across most of Latin America. However, there is little information readily available for Central America and the Caribbean basin...
September 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28917298/high-prevalence-of-bovine-cysticercosis-found-during-evaluation-of-different-post-mortem-detection-techniques-in-belgian-slaughterhouses
#13
Famke Jansen, Pierre Dorny, Dirk Berkvens, Anke Van Hul, Nick Van den Broeck, Caroline Makay, Nicolas Praet, Ramon Marc Eichenberger, Peter Deplazes, Sarah Gabriël
Bovine cysticercosis (BCC), caused by the helminth Taenia saginata, is currently diagnosed solely by official meat inspection (MI) based on macroscopic detection of viable cysticerci or typical lesions of degenerated larvae. MI has a known low sensitivity (<16%), leading to a large proportion of infected cattle carcasses entering the human food chain and posing a risk to public health. Prevalence in Belgium based on MI results is estimated at around 0.22%. Due to the low sensitivity of MI, alternative techniques to detect BCC should be considered...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28914356/in-vivo-treatment-with-nitazoxanide-induces-anaerobic-metabolism-in-experimental-intraperitoneal-cysticercosis
#14
Joelma M Nasareth, Carolina M Fraga, Nayana F Lima, Guaraciara A Picanço, Tatiane L Costa, Ruy S Lino-Junior, Marina Clare Vinaud
Taenia crassiceps cysticerci are used as experimental model to study the host-parasite relationship and treatment of cysticercosis. One of the described mode of actions of nitazoxanide (NTZ) is to block the pyruvate ferredoxine oxidoreductase (PFOR) enzyme which is an essential enzyme to the parasite metabolism. The aim of this study was to determine the in vivo influence of one dosage of NTZ on the energetic metabolism of T. crassiceps cysticerci. Thirty days after the intraperitoneal inoculation of T. crassiceps cysticerci, BALB/c mice were orally treated with 7...
September 15, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28910450/neglected-intraocular-cysticercosis
#15
Parthopratim Dutta Majumdar, Bikramjit P Pal
No abstract text is available yet for this article.
September 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28903870/spatial-distribution-of-bovine-cysticercosis-a-retrospective-study-in-brazil-from-2010-through-2015
#16
Gabriel Augusto Marques Rossi, Isabella Vilhena Freire Martins, Rafael Ferraço de Campos, Luiz Filippe Simão Soares, Henrique Meiroz de Souza Almeida, Luis Antonio Mathias
Geographical Information Systems (GIS) is frequently used in the control of animal diseases. In Brazil, the most impacting economical loss in the beef supply chain is bovine cysticercosis. This study focused on assessing the prevalence and geospatial distribution of bovine cysticercosis in 19 Brazilian states. To this, we gathered data from 146,346,244 bovines slaughtered between the years of 2010 and 2015. The observed prevalence was 0.62% (C.I. 0.62-0.63). In total, 30.86% cysticerci were viable, while 69...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28892472/target-product-profiles-for-the-diagnosis-of-taenia-solium-taeniasis-neurocysticercosis-and-porcine-cysticercosis
#17
Meritxell Donadeu, Anna S Fahrion, Piero L Olliaro, Bernadette Abela-Ridder
Target Product Profiles (TPPs) are process tools providing product requirements to guide researchers, developers and manufacturers in their efforts to develop effective and useful products such as biologicals, drugs or diagnostics. During a WHO Stakeholders Meeting on Taenia solium diagnostics, several TPPs were initiated to address diagnostic needs for different stages in the parasite's transmission (taeniasis, human and porcine cysticercosis). Following the meeting, draft TPPs were completed and distributed for consultation to 100 people/organizations, including experts in parasitology, human and pig cysticercosis, diagnostic researchers and manufacturers, international organizations working with neglected or zoonotic diseases, Ministries of Health and Ministries of Livestock in some of the endemic countries, WHO regional offices and other interested parties...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28878524/a-microbial-old-friend-with-a-new-face-a-rare-case-of-pyrexia-of-unknown-origin-and-leukemoid-reaction
#18
Sumeet P Mirgh, Virti D Shah, Jehangir S Sorabjee
We present a case of a young male, who presented to us with high-grade fever for more than four weeks, refractory seizures, multiple subcutaneous palpable lumps, and evidence of leukocytosis with predominant left shift on the peripheral smear. The classic "starry-sky" appearance on imaging, generalized muscular uptake on positron emission tomography-computerized tomography scan, and positive serology led to a diagnosis of disseminated cysticercosis. He responded to oral steroids. To the best of our knowledge, disseminated cysticercosis presenting as pyrexia of unknown origin and with a leukemoid reaction has never been reported in literature...
July 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28865900/a-benzimidazole-derivative-rcb15-in-vitro-induces-the-alternative-energetic-metabolism-and-glycolysis-in-taenia-crassiceps-cysticerci
#19
Guaraciara de Andrade Picanço, Nayana Ferreira de Lima, Carolina Miguel Fraga, Tatiane Luiza da Costa, Eliana Isac, Javier Ambrosio, Rafael Castillo, Marina Clare Vinaud
The emergence of resistance to albendazole has encouraged the search for effective alternatives for cysticercosis and other parasitosis treatment. RCB15 is a benzimidazole derivative that may be used against such diseases. The aim of this study was to determine the in vitro effect of RCB15 on the alternative energetic pathways of Taenia crassiceps cysticerci. The cysticerci were in vitro exposed to albendazole sulphoxide (ABZSO) or RCB15 at different concentrations during 24h. The cysticerci extract and the culture medium were analyzed through spectrophotometry and high performance liquid chromatography as to detect glucose, urea, creatinine and organic acids of the energetic metabolism...
December 2017: Acta Tropica
https://www.readbyqxmd.com/read/28861361/cysticercosis-of-the-eye
#20
REVIEW
Rebika Dhiman, Saranya Devi, Kavitha Duraipandi, Parijat Chandra, Murugesan Vanathi, Radhika Tandon, Seema Sen
Cysticercosis is a preventable and eradicable cause of blindness endemic in the Indian subcontinent, South-East Asia and other developing countries. Ocular and orbital cysticercosis has varied presentations depending upon the site of involvement, number of lesion and the host immune response. In this article we present a review of the various clinical manifestations, diagnosis and management protocol for orbital and ocular cysticercosis. Owing to its varied presentation, cysticercosis may pose a diagnostic challenge to the health professionals...
2017: International Journal of Ophthalmology
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