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Linxia Fang, Fan Wang, Zhenghua Chen, Yan Qiu, Tianli Zhai, Mengmeng Hu, Cuijie Zhang, Kejing Huang
In this study, a novel nanohybrid consisting of flower-like MoS2 decorated with Cu2 O nanoparticles has been successfully synthesized for non-enzymatic amperometric sensing of glucose. Structural characterizations revealed that Cu2 O nanoparticles were highly dispersed on MoS2 nanosheets. Electrochemical performances were investigated by cyclic voltammetry (CV) and chronoamperometry. Compared to single Cu2 O component, the-synthesized Cu2 O/MoS2 nanohybrid showed superior electrocatalysis to the oxidation of glucose...
May 15, 2017: Talanta
Neil Gibson, Hubert Rauscher, Gert Roebben
In November 2015, an article by A. J. Lecloux was published in this journal (J Nanopart Res, 17:447, 2015). The article focused on the use of volume-specific surface area (VSSA) for the implementation of the European Commission's recommended definition of "nanomaterial". In that paper, VSSA values were calculated for polydisperse particulate materials using a particle number-based averaging method which do not agree with earlier results of VSSA simulations of polydisperse materials reported in 2014 by the Joint Research Centre (JRC) of the European Commission (EC)...
2016: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
Yanhua Cao, Dong Wang, Qingzhao Li, Hongliang Deng, Jian Shen, Guoying Zheng, Miao Sun
Lead sulfide nanoparticals (PbS NPs) is an important semiconductor material due to its unique physical and chemical properties, but its potential health hazard to reproductive system is not clear. In the current study, we systematically explored the reproductive toxicity of PbS NPs in rats by measuring the body weight and testicular coefficient, testing serum testosterone levels, and studying the sperm survival rate and sperm abnormality rate. Furthermore, in order to study the toxic mechanism we performed lead contents measurements in testis, and investigated the pathology in testis...
March 2016: Journal of Nanoscience and Nanotechnology
Bartosz A Grzybowski, Wilhelm T S Huck
For some decades now, nanotechnology has been touted as the 'next big thing' with potential impact comparable to the steam, electricity or Internet revolutions - but has it lived up to these expectations? While advances in top-down nanolithography, now reaching 10-nm resolution, have resulted in devices that are rapidly approaching mass production, attempts to produce nanoscale devices using bottom-up approaches have met with only limited success. We have been inundated with nanoparticles of almost any shape, material and composition, but their societal impact has been far from revolutionary, with growing concerns over their toxicity...
July 6, 2016: Nature Nanotechnology
M A Sanzhakov, D V Ignatov, L V Kostryukova, O S Druzhilovskaya, N V Medvedeva, V N Prozorovskyi, O M Ipatova
The use of targeted transport systems for drug delivery is a promising approach to improve pharmacokinetics of drug substances, accumulation in the lesion. In this study we have obtained and characterized the pharmaceutical composition of doxorubicin in colloidal nanoparticles equipped with targeted conjugates based on folic acid and biotin with dodecylamine. The inclusion of the address fragments into colloidal nanopartical was carried out without surface and drug substance modification The accumulation of anthracycline antibiotic doxorubicin in tumor tissue was compared in Lewis lung carcinoma mouse models after intravenous administration of the composition of colloidal nanoparticles with targeted conjugates biotin-dodecylamine and folic acid-dodecylamine or free doxorubicin...
March 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
C Bao, X Dong, J Tao, J Lu, T Luo, J Liu
In this paper, an efficient method for determination of total pyrene concentration in the biological samples including plasma, liver, spleen, lung and kidney of Sprague-Dawley rats were investigated and established using steady-state fluorescence method. Equilibrium dialysis method was applied to determine plasma protein binding rate of pyrene. The results illustrated that the protein binding rate depends on the concentration of pyrene in plasma. Extraction of pyrene in plasma was studied by using biomedical nanopartical which was prepared from synthesized associating polymer poly(ethylene glycol) end-capped by hexadecane...
March 20, 2016: Cellular and Molecular Biology
Xiaoyan Liu, Yuan Peng, Jialei Bai, Zhiwei Qie, Baoan Ning, Zhixian Gao
OBJECTIVE: To develop a quartz crystal microbalance (QCM) immunosensor with high sensitivity and selectivity for the rapid detection of diethylstilbestrol. METHODS: Dextran was used as reducing agent for preparing gold nanoparticles (AuNPs) with the size of 40 nm. The AuNPs were coupled with anti-DES antibody after amination. A monolayer was generated after immersing the quartz crystal into the solution of 5 mmol/L 11-mercaptoundecanoic acid(MUA) for 16 hours. After the monolayer was activated by 1-ethyl-3-(3-dimethylaminopropry) carbodiimide hydrochloride (EDC·HCl) and N-hydrosuccinimide (NHS), 20 μl of 2...
March 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Yan-Qing Yu, Ji-Peng Wang, Min Zhao, Lin-Ru Hong, Ya-Qin Chai, Ruo Yuan, Ying Zhuo
Herein, a new electrochemiluminescence (ECL) strategy for enzyme-free microRNA-21 (miR-21) amplified detection was designed based on target-catalyzed hairpin assembly by combining the signal-amplification capability of both intramolecular and intermolecular ECL co-reaction. In this strategy, two hairpin DNA probes of H1 and H2 were designed as capture probes and detection probes, respectively. To be specific, the capture probes of H1 were immobilized on the multilayer interface of AuNPs and thiosemicarbazide (TSC) assembly on the single-walled carbon nanohorns decorated electrode, while the detection probes of H2 was anchored on the nanocarriers of gold nanoparticals functionalized reduced graphene oxide (Au-rGO) which were tagged with the self-enhanced ruthenium complex (PEI-Ru(ΙΙ)) in advance...
March 15, 2016: Biosensors & Bioelectronics
Linen Wu, Siman Fang, Lei Ge, Changcun Han, Ping Qiu, Yongji Xin
Novel Ag@CeO2 core-shell nanostructures with well-controlled shape and shell thickness were successfully synthesized via a green and facile template-free approach in aqueous solution. As-prepared samples were characterized by high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible diffuse reflection spectroscopy (DRS), electron spin resonance (ESR) and photoluminescence spectroscopy (PL). The structures with different core shapes and controllable shell thickness exhibited unique optical properties...
December 30, 2015: Journal of Hazardous Materials
Kun Guo, Rui Xiao, Xiaoye Zhang, Chaoguang Wang, Qiqi Liu, Zhen Rong, Lin Ye, Suhong Chen
Surface-enhanced Raman detection of thiram is demonstrated by using Ag-nanoparticles (Ag NPs) on Au film over nanosphere (AuFON) substrate as the hybrid substrate. The SERS signal of the Ag NPs attached to solid supports is studied. The close coupling together of thousands of Ag NPs on AuFON leads to the generation of hot spots for SERS. The Ag NPs on AuFON can be applied to detect rhodamine-6G (R6G) with the detection limitation of 10-11 M and the pesticide thiram in acetone with a detection limit of as low as 0...
April 9, 2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Sher Bahadar Khan, Mohammed M Rahman, Kalsoom Akhtar, Abdullah M Asiri
Composite nanoparticles were synthesized by eco-friendly hydrothermal process and characterized by different spectroscopic techniques. All the spectroscopic techniques suggested the synthesis of well crystalline optically active composite nanoparticles with average diameter of ∼ 30 nm. The synthesized nanoparticles were applied for the development of chemical sensor which was fabricated by coating the nanoparticles on silver electrode for the recognition of phthalimide using simple I-V technique. The developed sensor exhibited high sensitivity (1...
2014: PloS One
Pan-Pan Gai, Cui-E Zhao, Ying Wang, E S Abdel-Halim, Jian-Rong Zhang, Jun-Jie Zhu
A novel electrochemical biosensing platform for nicotinamide adenine dinucleotide (NAD(+))-dependent dehydrogenase catalysis was designed using the nitrogen-doped graphene (NG), which had properties similar to NADH dehydrogenase (CoI). NG mimicked flavin mononucleotide (FMN) in CoI and efficiently catalyzed NADH oxidation. NG also acted as an electron transport "bridge" from NADH to the electrode due to its excellent conductivity. In comparison with a bare gold electrode, an 800 mV decrease in the overpotential for NADH oxidation and CoI-like behavior were observed at NG-modified electrode, which is the largest decrease in overpotential for NADH oxidation reported to date...
December 15, 2014: Biosensors & Bioelectronics
LiPing Hu, Nan Wu, Jing Zheng, JingLi Xu, Min Zhang, PinGang He
A magnetic metal organic framework (MOF) composite was prepared. The composite was fabricated by incorporation of Fe3O4 nanoparticals with MOF. It was characterized and expected to offer a promising template for molecular immobilization and sensor fabrication because of its ordered structure and satisfying large specific surface area. The resulting composite was used to detect methyl parathion. Electrochemical measurements showed that the multifunctional composite of MOF provided an excellent matrix for the co-adsorption of methyl parathion...
2014: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Li-Feng Ding, Gang Zheng, Jun Yang, Zhen-Dong Zhou, Jian-Jun Li
OBJECTIVE: Polyethylene glycol/bone morphogenetic protein-2 (PEG/BMP-2) nanoparticles were transfected into Rabbit bone mesenchymal stem cells (rBMSCs) and the expression of BMP-2 was detected. METHODS: Dissociated rBMSCs were primarily cultured in vitro and BMP-2 gene was transfected into rBMSCs by PEG/BMP-2 nanoparticals and lipofectamine, respectively. The efficiency of transfection was detected by flow cytometry and the expression of BMP-2 was detected by Western Blot and real time RT-PCR...
January 2014: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Jialong Chen, Nan Huang, Baolong Ma, Manfred F Maitz, Juan Wang, Jingan Li, Quanli Li, Yuancong Zhao, Kaiqin Xiong, Xin Liu
Stem cells contribute to physiological processes such as postischemic neovascularization and vascular re-endothelialization, which help regenerate myocardial defects or repair vascular injury. However, therapeutic efficacy of stem cell transplantation is often limited by inefficient homing of systemically administered cells, which results in a low number of cells accumulating at sites of pathology. In this study, anti-CD34 antibody-coated magnetic nanoparticles (Fe3O4@PEG-CD34) are shown to have high affinity to stem cells...
July 10, 2013: ACS Applied Materials & Interfaces
G Martínez, E Tangarife, M Pérez, J Mejía-López
Accurate first-principle calculations on bimetallic cobalt-copper clusters of up to six atoms (Pérez et al 2012 J. Nanopart. Res. 14 933) revealed a close similarity of the ground-state magnetic properties to the ultimate jellium model, provided that a 2D to 3D geometric transition was invoked. We discuss this relationship in terms of partial occupancies of the valence electrons in both cases, with the jellium results described by nonperturbative spherical wavefunctions. Based upon this, we propose a scheme to predict magnetic properties of cobalt-copper clusters of up to twenty atoms using arguments of dimensionality and charge localization, and confirm some of these results with other independent density-functional calculations and experimental available data...
May 29, 2013: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Xiaoyun Qin, Wenbo Lu, Yonglan Luo, Guohui Chang, Abdullah M Asiri, Abdulrahman O Al-Youbi, Xuping Sun
In this paper, a stable aqueous dispersion of graphene nanosheets (GNs) has been prepared by chemical reduction of graphene oxide (GO) with hydrazine hydrate in the presence of poly [(2-ethyldimethylammonioethyl methacrylate ethyl sulfate)-co-(1-vinylpyrrolidone)] (PQ11). Taking advantages of the fact that PQ11 is a positively charged polymer exhibiting reducing ability, we further demonstrated the subsequent decoration of GN with gold nanoparticals (AuNPs) by in-situ chemical reduction of HAuCl4. It was found that such nanocomposites exhibit good catalytic activity toward 4-nitrophenol (4-NP) reduction and the GN supports also enhance the catalytic activity via a synergistic effect...
April 2012: Journal of Nanoscience and Nanotechnology
S K Pirutin, V B Turovetskiĭ, Iu M Efremov, K V Shaĭtan, Iu B Kudriashov, A B Rubin
The damaging effect of "Poviargol", a substance containing silver nanoparts, was studied. It was shown that the damaging effect of "Poviargol" took place from the concentration of 2 mkg/ml and got its maximum at 10-12 microg/ml. Decrease of the incubation temperature from 30 to 4 degreesC led to amplification of the membrane-acting effect of "Poviargol"; however, inverse relation was observed in the range from 37 to 30 degreesC. The damaging effect of "Poviargol" increased when pH of the incubating medium was raised to 8...
January 2012: Radiatsionnaia Biologiia, Radioecologiia
D Y Ju, P Bian, T Kumazawa, M Nakano, H Matsuura, K Umetani, T Komdo, Y Uozumi, K Makino, N Noda, K Koide, M Akutsu, K Masuyama
In this study, the composite magnetic nanoparticles of coated SiO nano film with about 8 nm size and high saturation magnetization value, were synthesized by liquid phase precipitation method. The magnetic nanoparticles can be dispersed in various liquid media, widely known as magnetic fluids or ferrofluids with both magnetic and liquid properties. The materials been collected great interests and more and more attentions to focus into Drug Delivery System (DDS) as a new technology in this paper. We use the composite nanoparticles to disperse H2O and inject the solutions into rat's in-vivo organs...
October 2011: Journal of Nanoscience and Nanotechnology
Elizabeth A Corley, Dietram A Scheufele, Qian Hu
Even though there is a high degree of scientific uncertainty about the risks of nanotechnology, many scholars have argued that policy-making cannot be placed on hold until risk assessments are complete (Faunce, Med J Aust 186(4):189-191, 2007; Kuzma, J Nanopart Res 9(1):165-182, 2007; O'Brien and Cummins, Hum Ecol Risk Assess 14(3):568-592, 2008; Powell et al., Environ Manag 42(3):426-443, 2008). In the absence of risk assessment data, decision makers often rely on scientists' input about risks and regulation to make policy decisions...
October 2009: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
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