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Calcification AND Blood pressure

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https://www.readbyqxmd.com/read/29300243/clinical-relevance-of-aortic-stiffness-in-end-stage-renal-disease-and-diabetes-implication-for-hypertension-management
#1
Alexandra Yannoutsos, Sola Aoun Bahous, Michel E Safar, Jacques Blacher
: Evidence suggests that aortic stiffness may antedate and contribute initially to the development of hypertension and cardiovascular risk (CVR). In treated hypertensive patients, both diabetes and end-stage renal disease (ESRD) are comorbid conditions associated with increased aortic stiffness and high CVR. Thus, the pathophysiological relationship between aortic stiffness, blood pressure (BP) and CVR may have clinical implication in the management of hypertension. In patients with diabetes or ESRD, aortic stiffness is a significant predictor of CVR, independently of BP control...
January 2, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29290026/trabecular-bone-quality-is-lower-in-adults-with-type-1-diabetes-and-is-negatively-associated-with-insulin-resistance
#2
V N Shah, R Sippl, P Joshee, L Pyle, W M Kohrt, I E Schauer, J K Snell-Bergeon
We evaluated trabecular bone score (TBS) and factors affecting TBS in adults with type 1 diabetes (T1D) compared to age-, sex-, and body mass index (BMI)-matched adults without diabetes. Adults with T1D had lower TBS compared to controls. Abdominal obesity and insulin resistance are associated with lower TBS. INTRODUCTION: We evaluated TBS, a non-invasive method to evaluate trabecular bone quality at the lumbar spine, in adults with T1D compared to age-, sex-, and BMI-matched adults without diabetes...
December 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29273504/fibroblast-growth-factor-21-ameliorates-vascular-calcification-by-inhibiting-osteogenic-transition-in-vitamin-d3-plus-nicotine-treated-rats
#3
Yuchen Shi, Weiwei Lu, Yuelong Hou, Kun Fu, Feng Gan, Jinghua Liu
FGF21, a special member of FGF superfamily, has been proven to have pleiotropic metabolic effects and many potential therapeutic action in various metabolic disorders. Vascular calcification (VC), a perplexing clinical issue, is a major risk factor for many cardiovascular diseases, especially for patients with some metabolic diseases. However, the role of FGF21 on VC in vivo remains unclear. Thus, in this study, we observed the effect and mechanism of FGF21 on VC induced by vitamin D3 plus nicotine (VDN) treated rats...
December 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29246501/multiethnic-study-of-breast-arterial-calcium-gradation-and-cardiovascular-disease-cohort-recruitment-and-baseline-characteristics
#4
Carlos Iribarren, Gabriela Sanchez, Gail Husson, Tory Levine-Hall, Charles Quesenberry, Danny L Sam, Joetta Maier, Rakesh S Chaudhary, Minal Patel, Bahman Sadeghi, Hanna Javan, Hyo-Min Cho, Huanjun Ding, Sabee Molloi
PURPOSE: MultIethNic Study of BrEast ARterial Calcium Gradation and CardioVAscular Disease (MINERVA) was designed to answer the question of whether a novel continuous breast arterial calcification (BAC) mass score improves cardiovascular risk stratification among asymptomatic postmenopausal women. This article describes recruitment and baseline characteristics. METHODS: MINERVA is a multiethnic longitudinal cohort study. The phenotype data include BAC mass by densitometry applied to digital mammograms, sociodemographic factors, self-reported medical history, medications, parental history, reproductive history, smoking, alcohol consumption, physical activity, anthropometry, ankle-brachial index, blood pressure, laboratory panel, breast volumes, cognitive function, bioelectrical impedance, habitual diet, dietary supplements, sleep, psychosocial factors, and sun exposure...
December 5, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29241485/normal-ldl-cholesterol-levels-are-associated-with-subclinical-atherosclerosis-in-the-absence-of-risk%C3%A2-factors
#5
Leticia Fernández-Friera, Valentín Fuster, Beatriz López-Melgar, Belén Oliva, José M García-Ruiz, José Mendiguren, Héctor Bueno, Stuart Pocock, Borja Ibáñez, Antonio Fernández-Ortiz, Javier Sanz
BACKGROUND: Absence of cardiovascular risk factors (CVRFs) is traditionally considered low risk for atherosclerosis; however, individuals without CVRFs, as currently defined, still have events. OBJECTIVES: This study sought to identify predictors of subclinical atherosclerosis in CVRF-free individuals. METHODS: Participants from the PESA (Progression of Early Subclinical Atherosclerosis) study (n = 4,184) without conventional CVRFs were evaluated (n = 1,779; 45...
December 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29228345/mechanisms-and-mediators-of-hypertension-induced-by-erythropoietin-and-related-molecules
#6
Rajiv Agarwal
Hypertension is a common but frequently overlooked adverse effect of erythropoietin (EPO) therapy. Underreporting of hypertension with EPO is likely due to either more aggressively managing hypertension through the prescription of antihypertensive drugs or closer attention to dry weight. The purpose and focus of this review is to critically evaluate the mechanisms of EPO-induced hypertension. Preclinical data are considered first, followed by clinical data where available. Mediated by a variety of molecules, there is an imbalance in the vascular tone favoring net vasoconstriction that mediates EPO-induced hypertension...
December 8, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29220533/androgens-irregular-menses-and-risk-of-diabetes-and-coronary-artery-calcification-in-the-diabetes-prevention-program
#7
Catherine Kim, Vanita R Aroda, Ronald B Goldberg, Naji Younes, Sharon L Edelstein, MaryLou Carrion-Petersen, David A Ehrmann
Context: It is unclear whether relative elevations in androgens or irregular menses (IM) are associated with greater cardiometabolic risk among women who are already overweight and glucose intolerant. Research Design and Methods: We conducted a secondary analysis of Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS). Participants included women with sex hormone measurements who did not use exogenous estrogen (n=1422). We examined whether free androgen index (FAI) or IM were associated with diabetes risk during the DPP/DPPOS or with coronary artery calcification (CAC) at DPPOS year 10...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29212987/association-of-coronary-artery-calcification-with-estimated-coronary-heart-disease-risk-from-prediction-models-in-a-community-based-sample-of-japanese-men-the-shiga-epidemiological-study-of-subclinical-atherosclerosis-sessa
#8
Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization...
December 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29174140/relation-of-coronary-artery-calcium-and-extra-coronary-aortic-calcium-to-incident-hypertension-from-the-multi-ethnic-study-of-atherosclerosis
#9
Amer I Aladin, Mahmoud Al Rifai, Shereen H Rasool, Zeina Dardari, Joseph Yeboah, Khurram Nasir, Matthew J Budoff, Bruce M Psaty, Roger S Blumenthal, Michael J Blaha, John W McEvoy
Arterial calcification reflects an atherosclerotic process associated with vascular stiffness. Whether baseline coronary artery calcium (CAC) and extra-coronary calcium (ECC), measured using noncontrast computed tomography imaging, are associated with incident hypertension is poorly understood. We studied participants from the Multi-Ethnic Study of Atherosclerosis without measured or self-reported hypertension at baseline. Incident hypertension was defined by blood pressure criteria (BP, ≥140/90 mmHg), BP medication use, or both, and was assessed at in-person visits...
October 24, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29170076/association-of-interleukin-6-with-aortic-stiffness-in%C3%A2-end-stage-renal-disease
#10
Marie-Pier Desjardins, Aboubacar Sidibé, Catherine Fortier, Fabrice Mac-Way, Karine Marquis, Sacha De Serres, Richard Larivière, Mohsen Agharazii
Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Aortic stiffness, a nontraditional risk factor, is associated with high rate of mortality in CKD. Using a CKD animal model with medial vascular calcification, we previously reported increased mRNA expression of interleukin-6 (IL-6), tumor necrosis factor (TNF), and interleukin-1β (IL-1β) in calcified aorta. The aim of the study was to investigate the association between IL-6, TNF, IL-1β, and aortic stiffness in end-stage renal disease patients...
October 13, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29153686/progression-of-gestational-hypertension-to-pre-eclampsia-a-cohort-study-of-20-103-pregnancies
#11
Kuo-Hu Chen, Kok-Min Seow, Li-Ru Chen
OBJECTIVE: To investigate previously un-identified risk factors for the progression of gestational hypertension (GH) to pre-eclampsia (PE) by considering Grade III preterm placental calcification (PPC) and excessive weight gain (≧10kgw) at 28weeks gestation. METHODS: At a tertiary teaching hospital, obstetric ultrasonography was performed at 28weeks gestation to establish a diagnosis of grade III PPC. Weight gain during pregnancy was recorded at the same time...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29142252/gallic-acid-reduces-blood-pressure-and-attenuates-oxidative-stress-and-cardiac-hypertrophy-in-spontaneously-hypertensive-rats
#12
Li Jin, Zhe Hao Piao, Simei Sun, Bin Liu, Gwi Ran Kim, Young Mi Seok, Ming Quan Lin, Yuhee Ryu, Sin Young Choi, Hae Jin Kee, Myung Ho Jeong
Gallic acid (GA) has been reported to have beneficial effects on cancer, vascular calcification, and diabetes-induced myocardial dysfunction. We hypothesized that GA controls hypertension via oxidative stress response regulation in an animal model for essential hypertension. Spontaneously hypertensive rats (SHRs) were administered GA for 16 weeks. GA treatment lowered elevated systolic blood pressure in SHRs through the inhibition of vascular contractility and components of the renin-angiotensin II system. In addition, GA administration reduced aortic wall thickness and body weight in SHRs...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050900/bone-and-mineral-disorders-in-chronic-kidney-disease-implications-for-cardiovascular-health-and-ageing-in-the-general-population
#13
REVIEW
Adrian Covic, Marc Vervloet, Ziad A Massy, Pablo Ureña Torres, David Goldsmith, Vincent Brandenburg, Sandro Mazzaferro, Pieter Evenepoel, Jordi Bover, Mugurel Apetrii, Mario Cozzolino
The patient with chronic kidney disease (CKD) represents an extreme model for arteriosclerosis, vascular calcification, and bone disorders, all of which are also associated with ageing in the general population. These pathological features are also relevant to other common chronic health disorders such as diabetes, and chronic inflammatory and cardiovascular diseases. Although management and interventions for these major risk factors are now incorporated into most public health guidelines (eg, smoking cessation and control of bodyweight and blood pressure, as well as glucose and cholesterol concentrations), some residual cardiovascular risk is not reduced by implementation of these interventions...
October 16, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29049308/the-relationship-between-intradialytic-hypotension-and-vascular-calcification-in-hemodialysis-patients
#14
AJin Cho, Young-Ki Lee, Jieun Oh, Jong-Woo Yoon, Dong Ho Shin, Hee Jung Jeon, Myung-Jin Choi, Jung-Woo Noh
BACKGROUND: Vascular calcification is associated with structural and functional abnormality of the heart and blood vessels. We investigated the relationship between intradialytic hypotension (IDH) and vascular calcification in hemodialysis (HD) patients, and their impacts on cardiovascular events (CVEs). METHOD: We enrolled 191 maintenance HD patients who underwent plain abdomen radiography for abdominal aortic calcification score (AACS). A nadir systolic blood pressure (BP) < 90 mm Hg or the requirement of bolus fluid administration was required to quantify the hypotension diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/29018027/abdominal-aortic-calcifications-influences-the-systemic-and-renal-hemodynamic-response-to-renal-denervation-in-the-denerhtn-renal-denervation-for-hypertension-trial
#15
Pierre-Yves Courand, Helena Pereira, Costantino Del Giudice, Philippe Gosse, Matthieu Monge, Guillaume Bobrie, Pascal Delsart, Claire Mounier-Vehier, Pierre Lantelme, Thierry Denolle, Caroline Dourmap, Jean Michel Halimi, Xavier Girerd, Patrick Rossignol, Faiez Zannad, Olivier Ormezzano, Bernard Vaisse, Daniel Herpin, Jean Ribstein, Beatrice Bouhanick, Jean-Jacques Mourad, Emile Ferrari, Gilles Chatellier, Marc Sapoval, Arshid Azarine, Michel Azizi
BACKGROUND: The DENERHTN (Renal Denervation for Hypertension) trial confirmed the efficacy of renal denervation (RDN) in lowering daytime ambulatory systolic blood pressure when added to standardized stepped-care antihypertensive treatment (SSAHT) for resistant hypertension at 6 months. METHODS AND RESULTS: This post hoc exploratory analysis assessed the impact of abdominal aortic calcifications (AAC) on the hemodynamic and renal response to RDN at 6 months. In total, 106 patients with resistant hypertension were randomly assigned to RDN plus SSAHT or to the same SSAHT alone (control group)...
October 10, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28992280/plasma-biomarkers-improve-prediction-of-diabetic-kidney-disease-in-adults-with-type-1-diabetes-over-a-12-year-follow-up-cacti-study
#16
Petter Bjornstad, Laura Pyle, David Z I Cherney, Richard J Johnson, Rachel Sippl, Randy Wong, Marian Rewers, Janet K Snell-Bergeon
Background: The objective of the study was to determine whether plasma biomarkers of kidney injury improve the prediction of diabetic kidney disease (DKD) in adults with type 1 diabetes (T1D) over a period of 12 years. Methods: Participants ( n  = 527, 53% females) in the Coronary Artery Calcification in T1D (CACTI) Study were examined during 2002-04, at a mean (± standard deviation) age of 39.6 ± 9.0 years with 24.8 years as the median duration of diabetes...
August 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28981523/associations-between-reflux-esophagitis-and-the-progression-of-coronary-artery-calcification-a-cohort-study
#17
Yang Won Min, Byeong Geun Song, Hye Seung Kim, Kyunga Kim, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Hee Jung Son, Poong-Lyul Rhee, Jae J Kim
BACKGROUND: Reflux esophagitis (RE) and coronary heart disease (CHD) have common risk factors, including obesity and metabolic syndrome. This study aimed to evaluate the associations between RE and the future CHD risk. METHODS: This retrospective cohort study included 8,221 participants who were ≥20 years old, and who underwent esophagogastroduodenoscopy and coronary computed tomography (CT) scans during the same visit and subsequent CT scans between 2003 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28957410/the-association-between-the-apolipoprotein-b-a-i-ratio-and-coronary-calcification-may-differ-depending-on-kidney-function-in-a-healthy-population
#18
Seok-Hyung Kim, Donghwan Oh, Kwon Soo Jung, Jung Eun Lee, Hyunwook Kim, Hyung Jong Kim, Beom Seok Kim, Hyeong Cheon Park, Byoung Kwon Lee, Hoon Young Choi
BACKGROUND: The apolipoprotein B/A-1 ratio has been reported to be one of the strongest risk predictors of cardiovascular events. However, its prognostic value for cardiovascular disease is still uncertain, especially in patients with chronic kidney disease. This study aimed to investigate whether the association between the apolipoprotein B/A-I ratio and coronary artery calcification differed according to kidney function in a healthy population. METHODS: Of the data from 7,780 participants from the medical records database in Gangnam Severance Hospital from 2005 through 2016, a cross-sectional analysis included participants with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1...
2017: PloS One
https://www.readbyqxmd.com/read/28923331/effects-of-low-density-lipoprotein-cholesterol-on-coronary-artery-calcification-progression-according-to-high-density-lipoprotein-cholesterol-levels
#19
Da Young Lee, Ji Hyun Kim, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee, Won-Young Lee
BACKGROUND AND AIM: Previous studies reported that many patients are at high risk for cardiovascular disease (CVD) despite achieving recommended low-density lipoprotein cholesterol (LDL-C) levels. Therefore, we investigated whether the association between LDL-C and the risk for incident CVD differed according to high-density lipoprotein cholesterol (HDL-C) levels using coronary artery calcium score (CACS) progression as a surrogate marker for predicting CVD. METHODS: We investigated 2132 Korean men in a health screening program, in which CACS was measured at baseline and after 4 years...
April 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28916241/relationship-of-echocardiographic-epicardial-fat-thickness-and-epicardial-fat-volume-by-computed-tomography-with-coronary-artery-calcification-data-from-the-caesar-study
#20
Byung Jin Kim, Jung Gyu Kang, Sung Ho Lee, Jong Young Lee, Ki Chul Sung, Bum Soo Kim, Jin Ho Kang
BACKGROUND AND AIMS: No study has assessed the association between echocardiographic epicardial fat thickness (EFT) and computed tomography (CT)-based epicardial fat volume (EFV) and coronary artery calcification. The aim of this study is to evaluate the association between EFT and EFV and coronary artery calcification. METHODS: Among the 2,299 individuals enrolled in the CArdiometabolic risk, Epicardial fat, and Subclinical Atherosclerosis Registry (CAESAR) study, 2,276 (1,851 men; mean age 45 ± 8...
September 12, 2017: Archives of Medical Research
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