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PAD AND Calcification

Jeremy C Lim, Dinesh Ranatunga, Andrew Owen, Tim Spelman, Michael Galea, Jason Chuen, Ruth P Lim
OBJECTIVE: The aim of this study was to evaluate image quality and accuracy of 64+ detector multidetector computed tomography angiography (MDCTA) for hemodynamically significant (≥50%) stenosis in patients with symptomatic peripheral arterial disease (PAD) using digital subtraction angiography as the reference standard. METHODS: This is a retrospective study of 29 patients with PAD (19 men, 10 women) who underwent lower limb MDCTA (64- or 80-detector) and digital subtraction angiography...
October 7, 2016: Journal of Computer Assisted Tomography
Hwa Seon Shin, Mi Jung Park, Kyung Nyeo Jeon, Jae Min Cho, Kyung Soo Bae, Dae Seob Choi, Jae Boem Na, Ho Cheol Choi, Hye Young Choi, Ji Eun Kim, Soo Bueum Cho, Sung Eun Park
BACKGROUND: Until now, there has been no study on the relationship between the calcification of the lower extremity arteries and significant coronary arterial disease (CAD). OBJECTIVES: To evaluate whether lower extremity calcium scores (LECS) are associated with CAD and whether this can predict multivessel-CAD in patients with peripheral arterial disease (PAD). PATIENTS AND METHODS: We retrospectively enrolled 103 PAD patients without cardiac symptoms or known CAD...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Steven T W van Haelst, Saskia Haitjema, Jean-Paul P M de Vries, Frans L Moll, Gerard Pasterkamp, Hester M den Ruijter, Gert J de Borst
OBJECTIVE: Diabetes mellitus (DM) is associated with peripheral arterial disease (PAD) and leads to worse clinical outcome compared with patients without DM. The objective of this study was to determine the impact of DM on iliofemoral artery plaque characteristics and to examine secondary clinical outcomes in patients with DM and PAD undergoing surgical revascularization. METHODS: We analyzed 198 patients with and 453 patients without DM from the Athero-Express biobank, a prospective ongoing biobank study, who underwent endarterectomy of the femoral or iliac artery between 2002 and 2013...
September 22, 2016: Journal of Vascular Surgery
Pasqualino Sirignano, Francesco Speziale, Laura Capoccia, Danilo Menna, Wassim Mansour, Nunzio Montelione, Francesco Setacci, Giuseppe Galzerano, Carlo Setacci
BACKGROUND: To evaluate the impact of iliac artery's diameters, tortuosity, and peripheral vascular patency on outcome of elective endovascular repair (EVAR) of abdominal aortic aneurysms (AAA) in 2 high volume vascular centers' experience. METHODS: A retrospective study was conducted on a prospectively collected database between 2010 and 2012. Anatomical features at pre-operative computed tomography (CTA) considered as potentially influencing outcomes were: iliac diameters, tortuosity (expressed as a ratio), and calcifications, bilateral internal iliac artery (IIA) patency, and presence of Trans-Atlantic Inter-Societies Consensus (TASC) II C/D femoro-popliteal occlusive disease (PAD)...
September 16, 2016: Journal of Cardiovascular Surgery
Linda E T Vissers, Geertje W Dalmeijer, Jolanda M A Boer, W M Monique Verschuren, Yvonne T van der Schouw, Joline W J Beulens
BACKGROUND AND AIMS: A high dietary intake of vitamin K1 (phylloquinone) and vitamin K2 (menaquinones) is thought to decrease cardiovascular disease risk by reducing vascular calcification. The objective of this study is to explore if there is a relationship between phylloquinone and menaquinones intake and risk of PAD. METHODS: We investigated the association between intake of phylloquinone and menaquinones with PAD in a prospective cohort with 36,629 participants...
September 2016: Atherosclerosis
Bradley Deere, Michael Griswold, Seth Lirette, Ervin Fox, Mario Sims
OBJECTIVES: African Americans experience higher rates of cardiovascular disease (CVD) and lower childhood and adult socioeconomic position (SEP). Research that examines the associations of multiple measures of SEP with subclinical CVD markers among African Americans is limited. METHODS: Data from the Jackson Heart Study (JHS) were used to examine cross-sectional associations of childhood SEP and adult SEP with subclinical markers among 4,756 African American participants (mean age 54, 64% female), adjusting for age, health behaviors and CVD risk factors...
2016: Ethnicity & Disease
Chin Yee Ho, Catherine M Shanahan
Peripheral arterial disease (PAD) is a global health issue that is becoming more prevalent in an aging world population. Diabetes mellitus and chronic kidney disease are also on the increase, and both are associated with accelerated vascular calcification and an unfavorable prognosis in PAD. These data challenge the traditional athero-centric view of PAD, instead pointing toward a disease process complicated by medial arterial calcification. Like atherosclerosis, aging is a potent risk factor for medial arterial calcification, and accelerated vascular aging may underpin the devastating manifestations of PAD, particularly in patients prone to calcification...
August 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Maja Jakimovska Dimitrovska, Nadica Mitreska, Menka Lazareska, Elizabeta Stojovska Jovanovska, Ace Dodevski, Aleksandar Stojkoski
AIM: The purpose of this study is to describe our experience with needle localization technique in diagnosing small breast cancers. MATERIAL AND METHODS: This retrospective study included a hundred and twenty patients' with impalpable breast lesions and they underwent wire localization. All patients had mammography, ultrasound exam and pathohystological results. We use Mammomat Inspiration Siemens digital unit for diagnosing mammography, machine - Lorad Affinity with fenestrated compressive pad for wire localization and ultrasound machine Acuson X300 with linear array probe 10 MhZ...
June 15, 2015: Open Access Maced J Med Sci
Abulimiti Zainuer, Yoshinori Inoue, Toshifumi Kudo, Takahiro Toyofuku, Kimihiro Igari, Tatsuyuki Kawano
UNLABELLED: The aim of this study was to investigate which parameters among the ankle brachial index (ABI), toe brachial pressure index (TBI) and transfer function index (TFI) are useful to accurately diagnose PAD in patients with / without arterial calcification, who have undergone some type of diagnostic imaging. PATIENTS AND METHODS: A total of 102 patients with 192 limbs (mean age: 72.0 ± 8.4 years) underwent plain radiography, ABI, TBI and TFI. A receiver operating characteristics (ROC) analysis was performed to assess possible threshold values that predict PAD in these patients...
2016: Journal of Medical and Dental Sciences
Cavin K Ward-Caviness, Lucas M Neas, Colette Blach, Carol S Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Elaine Dowdy, Robert B Devlin, David Diaz-Sanchez, Wayne E Cascio, Marie Lynn Miranda, Simon G Gregory, Svati H Shah, William E Kraus, Elizabeth R Hauser
There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD)...
2016: PloS One
Dae-Hee Lee, Tae-Wan Jeong
Primary synovial chondromatosis is a rare condition of idiopathic synovial chondrometaplasia and usually occurs during the third to fifth decades of life. Conversely, secondary synovial chondromatosis results from the growth of separated particles from articular cartilage or osteophytes in patients with joint diseases, such as degenerative osteoarthritis, and occurs mostly in elderly people. We describe here a 76-year-old male histopathologically confirmed as having primary synovial chondromatosis with no calcification of the infrapatellar fat pad (IFP) of the knee joint...
March 2016: Knee Surgery & related Research
Michael C Langham, Benoit Desjardins, Erin K Englund, Emile R Mohler, Thomas F Floyd, Felix W Wehrli
RATIONALE AND OBJECTIVES: Contrast-enhanced angiographic evaluation by magnetic resonance imaging (MRI) and computed tomography (CT) is the reference standard for assessing peripheral artery disease (PAD). However, because PAD and diabetes often coexist, the prevalence of renal insufficiency is a major challenge to contrast-based angiography. The objective of this work is to describe and demonstrate a new application of three-dimensional double-echo steady-state (3D DESS) as a noncontrast vascular MRI method for evaluating peripheral atherosclerosis at 3 Tesla (3T)...
April 2016: Academic Radiology
Yoshiaki Hojo, Hisao Kumakura, Hiroyoshi Kanai, Toshiya Iwasaki, Shuichi Ichikawa, Masahiko Kurabayashi
AIMS: Lipoprotein(a) (Lp(a)) levels have been associated with aortic valvular calcification and stenosis. The prevalence and risk factors, including Lp(a) level, for valvular heart disease (VHD) were investigated in patients with peripheral arterial disease (PAD). METHODS AND RESULTS: Echocardiography was performed in 861 patients with PAD to detect abnormal cardiac findings. Relationships between VHD and risk factors were analysed. The prevalence of VHD was 43...
May 2016: European Heart Journal Cardiovascular Imaging
Michiko Suzuki, Ryoichi Tanaka, Kunihiro Yoshioka, Akihiko Abiko, Shigeru Ehara
PURPOSE: Accurate evaluation of stenosis in severely calcified arteries is a major challenge in conventional CT angiography (CTA) for peripheral arterial disease (PAD). The aim of this study was to evaluate the efficacy of subtraction CTA compared with conventional CTA and conventional angiography. MATERIALS AND METHODS: 175 arterial segments of 31 consecutive patients with PAD who underwent CTA and subsequent digital subtraction angiography (DSA) were evaluated...
March 2016: Japanese Journal of Radiology
Jacqueline Uson, Roberto Miguélez-Sánchez, Marina de Los Riscos, María Jesús Martínez-Blasco, Cruz Fernández-Espartero, Virginia Villaverde-García, Jesús Garrido, Esperanza Naredo
The main objective of this cross-sectional observational study was to investigate the relationship between clinical, ultrasonographic (US) and radiographic elbow features in patients with inflammatory joint diseases (IJD). The secondary objective was to evaluate the association between regional clinical elbow diagnoses and imaging findings. Consecutive patients with IJD attending follow-up visits were assessed for elbow pain and standardized elbow examination. Seven regional clinical diagnoses were defined...
March 2016: Rheumatology International
George L Adams, Tony Das, Michael S Lee, Robert Beasley, Jihad Mustapha
PURPOSE: Patients with peripheral arterial disease (PAD) can be classified into groups based upon the severity of the disease using the Rutherford classification system. This analysis compares the procedural outcomes of PAD patients treated with orbital atherectomy stratified by Rutherford class (1-3 = intermittent claudication; 4-6 = critical limb ischemia [CLI]), and acute angiographic outcomes of these patients stratified by degree of lesion calcification. METHODS: The CONFIRM registry series was analyzed and included 1697 patients with intermittent claudication (Rutherford class 1-3) and 1320 patients with CLI (Rutherford class 4-6) treated with orbital atherectomy...
November 2015: Journal of Invasive Cardiology
Katja Voss, Philemon Karli, Pierre M Montavon, Hans Geyer
OBJECTIVES: The aim of the study was to evaluate the prevalence, size, location and appearance of mineralisations in feline stifle joints, and to evaluate their relationship with osteoarthritis and cranial cruciate ligament (CrCL) status. METHODS: Presence or absence, and size of mineralisations were determined from lateral stifle radiographs of 25 cats with CrCL rupture, and 44 cat cadavers without CrCL rupture. Mineralisations were classified as small, medium or large...
October 14, 2015: Journal of Feline Medicine and Surgery
Nandini M Meyersohn, T Gregory Walker, George R Oliveira
Peripheral artery disease (PAD) has become increasingly common in the US patient population and can be a highly symptomatic and significant source of morbidity. When PAD is suspected, the first-line screening study that is obtained is typically a noninvasive evaluation that includes the ankle brachial index (ABI). Following a positive screening study, invasive catheter digital subtraction angiography (DSA) has been historically used to image the peripheral artery system and still remains the gold standard. However, newer developments in axial imaging including computed tomography angiography (CTA) and magnetic resonance angiography (MRA) have in large part supplanted DSA for imaging the peripheral artery system in clinical practice...
October 2015: Current Cardiology Reports
John H Rundback, Kevin Chaim Herman, Amish Patel
Femoropopliteal (FP) disease is a common presentation of peripheral arterial disease (PAD), and a challenging anatomic region for durable treatment. Surgical bypass has historically been the primary therapeutic modality, but has been supplanted in the last decade by endovascular therapy, even with the most complex presentation of disease. Endovascular therapy has the advantage of a more favorable and rapid recovery, while preserving future treatment options. Endovascular management of FP disease, initially with "Plain Old" balloon angioplasty (POBA) has yielded over the years to bare metal stents (BMS), and more recently, to technologies seeking to limit BMS use due to difficult-to-treat patterns of in-stent restenosis (ISR)...
September 2015: Current Treatment Options in Cardiovascular Medicine
Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue
BACKGROUND: Endovascular treatment (EVT) for chronic total occlusion (CTO) is a technically challenging problem in peripheral arterial disease (PAD). The Crosser system is a CTO device with high frequency vibrational energy to cross the CTO, which has been adopted for coronary CTO. We performed EVT procedure by the device for PAD with CTO, and the purpose of this study was to evaluate the efficacy and safety of a high-frequency vibrational device, the Crosser™ system, in the EVT for the infrainguinal arteries with CTO...
April 2016: International Angiology: a Journal of the International Union of Angiology
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