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Skin rejuvination

Yan Peng, Min Xuan, Victor Y L Leung, Biao Cheng
The skin is the body's largest organ and it is able to self-repair throughout an individual's life. With advanced age, skin is prone to degenerate in response to damage. Although cosmetic surgery has been widely adopted to rejuvinate skin, we are far from a clear understanding of the mechanisms responsible for skin aging. Recently, adult skin-resident stem/progenitor cells, growth arrest, senescence or apoptotic death and dysfunction caused by alterations in key signaling genes, such as Ras/Raf/MEK/ERK, PI3K/Akt-kinases, Wnt, p21 and p53, have been shown to play a vital role in skin regeneration...
January 2015: Ageing Research Reviews
L B Robbins, D B Brothers, D M Marshall
Prominent nasomandibular folds and cheek concavities are common sequelae of the aging process. The difficulty in achieving initial and long-lasting correction has been well documented. Anterior SMAS plication as an adjunct to subcutaneous rhytidectomy has proven to be an effective, straightforward method of flattening and rejuvinating the nasomandibular folds. Ptotic cheek fat is returned to the cheek hollow, and the end result is a more youthful, symmetrical flattening of the nasomandibular folds and jowls...
November 1995: Plastic and Reconstructive Surgery
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