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Charles vollmer

Daniel E Abbott, Ching Wei D Tzeng, Matthew T McMillan, Mark P Callery, Tara S Kent, John D Christein, Stephen W Behrman, Daniel P Schauer, Dennis J Hanseman, Mark H Eckman, Charles M Vollmer
BACKGROUND: As payment models evolve, disease-specific risk stratification may impact patient selection and financial outcomes. This study sought to determine whether a validated clinical risk score for post-operative pancreatic fistula (POPF) could predict hospital costs, payments, and profit margins. METHODS: A multi-institutional cohort of 1193 patients undergoing pancreaticoduodenectomy (PD) were matched to an independent hospital where cost, in US$, and payment data existed...
November 21, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Giuseppe Malleo, Charles M Vollmer
Although mortality rates after pancreatectomy have decreased, the incidence of postoperative morbidity remains high. The major procedure-related complications are pancreatic fistula, delayed gastric emptying, and postpancreatectomy hemorrhage. The International Study Group of Pancreatic Surgery defined leading complications in a standardized fashion, allowing unbiased comparison of operative results and management strategies. Risk factors for postoperative complications have been investigated and quantitative scoring systems established to estimate patient-specific risks...
December 2016: Surgical Clinics of North America
Orlando Jorge Martins Torres, Márcio Carmona Marques, Fabio Nasser Santos, Igor Correia de Farias, Anelisa Kruschewsky Coutinho, Cássio Virgílio Cavalcante de Oliveira, Antonio Nocchi Kalil, Celso Abdon Lopes de Mello, Jaime Arthur Pirola Kruger, Gustavo Dos Santos Fernandes, Claudemiro Quireze, André M Murad, Milton José de Barros E Silva, Charles Edouard Zurstrassen, Helano Carioca Freitas, Marcelo Rocha Cruz, Rui Weschenfelder, Marcelo Moura Linhares, Leonaldson Dos Santos Castro, Charles Vollmer, Elijah Dixon, Héber Salvador de Castro Ribeiro, Felipe José Fernandez Coimbra
In the last module of this consensus, controversial topics were discussed. Management of the disease after progression during first line chemotherapy was the first discussion. Next, the benefits of liver resection in the presence of extra-hepatic disease were debated, as soon as, the best sequence of treatment. Conversion chemotherapy in the presence of unresectable liver disease was also discussed in this module. Lastly, the approach to the unresectable disease was also discussed, focusing in the best chemotherapy regimens and hole of chemo-embolization...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Matthew T McMillan, Brett L Ecker, Stephen W Behrman, Mark P Callery, John D Christein, Jeffrey A Drebin, Douglas L Fraker, Tara S Kent, Major K Lee, Robert E Roses, Michael H Sprys, Charles M Vollmer
BACKGROUND: Evidence suggests externalized trans-anastomotic stents may be beneficial as a fistula mitigation strategy for pancreatoduodenectomy (PD); however, previous studies have not been rigorously risk-adjusted. METHODS: From 2001 to 2015, PDs were performed at three institutions, with externalized stents placed at the surgeon's discretion. The Fistula Risk Score (FRS) and the Modified Accordion Severity Grading System were used to analyze occurrence and severity of clinically relevant postoperative pancreatic fistula (CR-POPF) across various risk scenarios...
October 11, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Marc G Besselink, L Bengt van Rijssen, Claudio Bassi, Christos Dervenis, Marco Montorsi, Mustapha Adham, Horacio J Asbun, Maximillian Bockhorn, Oliver Strobel, Markus W Büchler, Olivier R Busch, Richard M Charnley, Kevin C Conlon, Laureano Fernández-Cruz, Abe Fingerhut, Helmut Friess, Jakob R Izbicki, Keith D Lillemoe, John P Neoptolemos, Michael G Sarr, Shailesh V Shrikhande, Robert Sitarz, Charles M Vollmer, Charles J Yeo, Werner Hartwig, Christopher L Wolfgang, Dirk J Gouma
BACKGROUND: Recent literature suggests that chyle leak may complicate up to 10% of pancreatic resections. Treatment depends on its severity, which may include chylous ascites. No international consensus definition or grading system of chyle leak currently is available. METHODS: The International Study Group on Pancreatic Surgery, an international panel of pancreatic surgeons working in well-known, high-volume centers, reviewed the literature and worked together to establish a consensus on the definition and classification of chyle leak after pancreatic operation...
September 28, 2016: Surgery
Armin Wiegner, Charles G Wright, Maike Vollmer
BACKGROUND: Animal models for chronic multichannel cochlear implant stimulation and selective neuronal activation contribute to a better understanding of auditory signal processing and central neural plasticity. NEW METHOD: This paper describes the design and surgical implantation of a multichannel cochlear implant (CI) system for chronic use in the free-moving gerbil. For chronic stimulation, adult-deafened gerbils were connected to a multichannel commutator that allowed low resistance cable rotation and stable electric connectivity to the current source...
August 9, 2016: Journal of Neuroscience Methods
Gene K Ma, David S Goldberg, Nikhil Thiruvengadam, Vinay Chandrasekhara, Michael L Kochman, Gregory G Ginsberg, Charles M Vollmer, Nuzhat A Ahmad
BACKGROUND: In 2015, the American Gastroenterological Association (AGA) published guidelines to provide recommendations for management of suspected pancreatic cystic neoplasms (PCNs). The aim of this study was to compare efficacy of these with the Fukuoka consensus guidelines in predicting advanced neoplasia (AN) in patients with suspected PCNs. STUDY DESIGN: We performed a retrospective study of 239 patients who underwent surgical resection for suspected mucinous PCN at a tertiary care center from 2000 to 2014...
November 2016: Journal of the American College of Surgeons
Chad G Ball, Elijah Dixon, Charles M Vollmer
BACKGROUND: Numerous clinical and basic science innovations have been presented at the AHPBA. The objective was to define changes in content and methodology of the scientific program over the past decade. METHODS: AHPBA abstracts from the past 10-years were reviewed by 2 investigators (volume, content, origin, methodology). RESULTS: Of 2194 total AHPBA abstracts (2005-2015), the volume per year decreased over time (2005 = 283; 2015 = 177; p < 0...
August 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Matthew T McMillan, Giuseppe Malleo, Claudio Bassi, Valentina Allegrini, Luca Casetti, Jeffrey A Drebin, Alessandro Esposito, Luca Landoni, Major K Lee, Alessandra Pulvirenti, Robert E Roses, Roberto Salvia, Charles M Vollmer
OBJECTIVE: This multicenter study sought to prospectively evaluate a drain management protocol for pancreatoduodenectomy (PD). BACKGROUND: Recent evidence suggests value for both selective drain placement and early drain removal for PD. Both strategies have been associated with reduced rates of clinically relevant pancreatic fistula (CR-POPF)-the most common and morbid complication after PD. METHODS: The protocol was applied to 260 consecutive PDs performed at two institutions over 17 months...
June 24, 2016: Annals of Surgery
Matthew T McMillan, Valentina Allegrini, Horacio J Asbun, Chad G Ball, Claudio Bassi, Joal D Beane, Stephen W Behrman, Adam C Berger, Mark Bloomston, Mark P Callery, John D Christein, Euan Dickson, Elijah Dixon, Jeffrey A Drebin, Carlos Fernandez-Del Castillo, William E Fisher, Zhi Ven Fong, Ericka Haverick, Robert H Hollis, Michael G House, Steven J Hughes, Nigel B Jamieson, Tara S Kent, Stacy J Kowalsky, John W Kunstman, Giuseppe Malleo, Amy L McElhany, Ronald R Salem, Kevin C Soares, Michael H Sprys, Vicente Valero, Ammara A Watkins, Christopher L Wolfgang, Amer H Zureikat, Charles M Vollmer
OBJECTIVE: This multicenter study sought to evaluate the accuracy of the American College of Surgeons National Surgical Quality Improvement Program's (ACS-NSQIP) surgical risk calculator for predicting outcomes after pancreatoduodenectomy (PD) and to determine whether incorporating other factors improves its predictive capacity. BACKGROUND: The ACS-NSQIP surgical risk calculator has been proposed as a decision-support tool to predict complication risk after various operations...
May 26, 2016: Annals of Surgery
Deniece Riviere, Kurinchi Selvan Gurusamy, David A Kooby, Charles M Vollmer, Marc G H Besselink, Brian R Davidson, Cornelis J H M van Laarhoven
BACKGROUND: Surgical resection is currently the only treatment with the potential for long-term survival and cure of pancreatic cancer. Surgical resection is provided as distal pancreatectomy for cancers of the body and tail of the pancreas. It can be performed by laparoscopic or open surgery. In operations on other organs, laparoscopic surgery has been shown to reduce complications and length of hospital stay as compared with open surgery. However, concerns remain about the safety of laparoscopic distal pancreatectomy compared with open distal pancreatectomy in terms of postoperative complications and oncological clearance...
April 4, 2016: Cochrane Database of Systematic Reviews
Charles Cole, Roger Volden, Sumedha Dharmadhikari, Camille Scelfo-Dalbey, Christopher Vollmers
Ab repertoire sequencing is a powerful tool to analyze the adaptive immune system. To sequence entire Ab repertoires, amplicons are created from Ab H chain (IgH) transcripts and sequenced on a high-throughput sequencer. The field of immune repertoire sequencing is growing rapidly and the protocols used are steadily improving; however, thus far, immune repertoire sequencing protocols have not been able to sequence full-length immune repertoires including the entire IgH V region and enough of the IgH C region to identify isotype subtypes...
March 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Lauren L Vollmer, Sarah Schmeltzer, Jennifer Schurdak, Rebecca Ahlbrand, Jennifer Rush, Charles M Dolgas, Mark L Baccei, Renu Sah
UNLABELLED: Neuropeptide Y (NPY), a 36 aa peptide, regulates stress and emotional behaviors. Preclinical and clinical studies support an association of NPY with trauma-evoked syndromes such as posttraumatic stress disorder (PTSD), although the exact contribution of NPY is not clear. In the current study, we examined functional attributes of NPY in the infralimbic (IL) cortex, an area that regulates fear memories and is reported to be hypoactive in PTSD. Carriers of NPY gene polymorphism rs16147 have been reported to have elevated prefrontal NPY expression...
January 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Matthew T McMillan, Sameer Soi, Horacio J Asbun, Chad G Ball, Claudio Bassi, Joal D Beane, Stephen W Behrman, Adam C Berger, Mark Bloomston, Mark P Callery, John D Christein, Elijah Dixon, Jeffrey A Drebin, Carlos Fernandez-Del Castillo, William E Fisher, Zhi Ven Fong, Michael G House, Steven J Hughes, Tara S Kent, John W Kunstman, Giuseppe Malleo, Benjamin C Miller, Ronald R Salem, Kevin Soares, Vicente Valero, Christopher L Wolfgang, Charles M Vollmer
OBJECTIVE: To evaluate surgical performance in pancreatoduodenectomy using clinically relevant postoperative pancreatic fistula (CR-POPF) occurrence as a quality indicator. BACKGROUND: Accurate assessment of surgeon and institutional performance requires (1) standardized definitions for the outcome of interest and (2) a comprehensive risk-adjustment process to control for differences in patient risk. METHODS: This multinational, retrospective study of 4301 pancreatoduodenectomies involved 55 surgeons at 15 institutions...
August 2016: Annals of Surgery
Alexander L Greninger, Kevin Messacar, Thelma Dunnebacke, Samia N Naccache, Scot Federman, Jerome Bouquet, David Mirsky, Yosuke Nomura, Shigeo Yagi, Carol Glaser, Michael Vollmer, Craig A Press, Bette K Kleinschmidt-DeMasters, Bette K Klenschmidt-DeMasters, Samuel R Dominguez, Charles Y Chiu
BACKGROUND: Primary amoebic meningoencephalitis (PAM) is a rare, often lethal, cause of encephalitis, for which early diagnosis and prompt initiation of combination antimicrobials may improve clinical outcomes. METHODS: In this study, we sequenced a full draft assembly of the Balamuthia mandrillaris genome (44.2 Mb in size) from a rare survivor of PAM, and recovered the mitochondrial genome from six additional Balamuthia strains. We also used unbiased metagenomic next-generation sequencing (NGS) and SURPI bioinformatics analysis to diagnose an ultimately fatal case of Balamuthia mandrillaris encephalitis in a 15-year-old girl...
December 1, 2015: Genome Medicine
Chad G Ball, Elijah Dixon, Charles M Vollmer, Thomas J Howard
Pancreaticoduodenectomy remains the exclusive technique for surgical resection of cancers located within both the pancreatic head and periampullary region. Amongst peri-procedural complications, hemorrhage is particularly problematic given that allogenic blood transfusions are known to increase the risk of infection, acute lung injury, cancer recurrence and overall 30-day morbidity and mortality rates. Because blood loss can be considered a modifiable factor that reflects surgical technique, rates of perioperative blood loss and transfusion have been advocated as robust quality indicators...
November 25, 2015: BMC Surgery
Matthew T McMillan, Russell S Lewis, Jeffrey A Drebin, Ursina R Teitelbaum, Major K Lee, Robert E Roses, Douglas L Fraker, Charles M Vollmer
BACKGROUND: The literature investigating pancreatic invasive intraductal papillary mucinous neoplasm (IPMN) has largely come from small institutional studies, preventing adequately powered comparisons of adjuvant therapy versus surgery alone (SA) within specific patient subgroups. METHODS: Patients with resected, stage I through IV, invasive IPMN and conventional pancreatic ductal adenocarcinoma (PDAC) were identified in the National Cancer Data Base (1998-2010)...
February 15, 2016: Cancer
Thomas A Aloia, William H Geerts, Bryan M Clary, Ryan W Day, Alan W Hemming, Luiz Carneiro D'Albuquerque, Charles M Vollmer, Jean-Nicolas Vauthey, Giles J Toogood
BACKGROUND: At a recently concluded Americas Hepato-Pancreato-Biliary Association Annual Meeting, a Clinical Practice Guidelines Conference Series was convened with the topic focusing on Venous Thromboembolism (VTE) Prophylaxis in Liver Surgery. The symposium brought together hepatobiliary surgeons from three continents as well as medical experts in hematology and coagulation. METHODS: The content of the discussion included literature reviews, evaluation of multi-institutional VTE outcome data, and examination of practice patterns at multiple high-volume centers...
January 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Matthew T McMillan, Giuseppe Malleo, Claudio Bassi, Michael H Sprys, Charles M Vollmer
BACKGROUND: Pancreatoduodenectomy (PD) is a technically challenging operation characterized by numerous management decisions. OBJECTIVE: This study was designed to test the hypothesis that there is significant variation in the contemporary global practice of PD. METHODS: A survey with native-language translation was distributed to members of 22 international gastrointestinal surgical societies. Practice patterns and surgical decision making for PD were assessed...
December 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Charles Elder, Lynn DeBar, Cheryl Ritenbaugh, William Vollmer, Richard A Deyo, John Dickerson, Lindsay Kindler
OBJECTIVES: To describe acupuncture and chiropractic use among patients with chronic musculoskeletal pain (CMP) at a health maintenance organization, and explore issues of benefit design and electronic medical record (EMR) capture. STUDY DESIGN: Cross-sectional survey. METHODS: Kaiser Permanente members meeting EMR diagnostic criteria for CMP were invited to participate. The survey included questions about self-identified presence of CMP, use of acupuncture and chiropractic care, use of ancillary self-care modalities, and communication with conventional medicine practitioners...
July 2015: American Journal of Managed Care
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