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Charles vollmer

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https://www.readbyqxmd.com/read/28096374/phylogenetic-analysis-of-the-human-antibody-repertoire-reveals-quantitative-signatures-of-immune-senescence-and-aging
#1
Charles F A de Bourcy, Cesar J Lopez Angel, Christopher Vollmers, Cornelia L Dekker, Mark M Davis, Stephen R Quake
The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig heavy-chain transcript sequences in both young and elderly individuals before and after influenza vaccination. We determined that BCR repertoires become increasingly specialized over a span of decades, but less plastic...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28040257/the-2016-update-of-the-international-study-group-isgps-definition-and-grading-of-postoperative-pancreatic-fistula-11-years-after
#2
REVIEW
Claudio Bassi, Giovanni Marchegiani, Christos Dervenis, Micheal Sarr, Mohammad Abu Hilal, Mustapha Adham, Peter Allen, Roland Andersson, Horacio J Asbun, Marc G Besselink, Kevin Conlon, Marco Del Chiaro, Massimo Falconi, Laureano Fernandez-Cruz, Carlos Fernandez-Del Castillo, Abe Fingerhut, Helmut Friess, Dirk J Gouma, Thilo Hackert, Jakob Izbicki, Keith D Lillemoe, John P Neoptolemos, Attila Olah, Richard Schulick, Shailesh V Shrikhande, Tadahiro Takada, Kyoichi Takaori, William Traverso, Charles R Vollmer, Christopher L Wolfgang, Charles J Yeo, Roberto Salvia, Marcus Buchler
BACKGROUND: In 2005, the International Study Group of Pancreatic Fistula developed a definition and grading of postoperative pancreatic fistula that has been accepted universally. Eleven years later, because postoperative pancreatic fistula remains one of the most relevant and harmful complications of pancreatic operation, the International Study Group of Pancreatic Fistula classification has become the gold standard in defining postoperative pancreatic fistula in clinical practice. The aim of the present report is to verify the value of the International Study Group of Pancreatic Fistula definition and grading of postoperative pancreatic fistula and to update the International Study Group of Pancreatic Fistula classification in light of recent evidence that has emerged, as well as to address the lingering controversies about the original definition and grading of postoperative pancreatic fistula...
December 28, 2016: Surgery
https://www.readbyqxmd.com/read/28030724/a-propensity-score-matched-analysis-of-robotic-vs-open-pancreatoduodenectomy-on-incidence-of-pancreatic-fistula
#3
Matthew T McMillan, Amer H Zureikat, Melissa E Hogg, Stacy J Kowalsky, Herbert J Zeh, Michael H Sprys, Charles M Vollmer
Importance: The adoption of robotic pancreatoduodenectomy (RPD) is gaining momentum; however, its impact on major outcomes, including pancreatic fistula, has yet to be adequately compared with open pancreatoduodenectomy (OPD). Objective: To demonstrate that use of RPD does not increase the incidence of clinically relevant pancreatic fistula (CR-POPF) compared with OPD. Design, Setting, and Participants: Data were accrued from 2846 patients who underwent pancreatoduodenectomies (OPDs, n = 2661; RPDs, n = 185), performed by 51 surgeons at 17 institutions worldwide (2003-2015)...
December 28, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/28029534/the-influence-of-fellowship-training-on-the-practice-of-pancreatoduodenectomy
#4
Gregory T Kennedy, Matthew T McMillan, Michael H Sprys, Claudio Bassi, Paul D Greig, Paul D Hansen, Dhiresh R Jeyarajah, Tara S Kent, Giuseppe Malleo, Giovanni Marchegiani, Rebecca M Minter, Charles M Vollmer
BACKGROUND: There has been a proliferation of gastrointestinal surgical fellowships; however, little is known regarding their association with surgical volume and management approaches. METHODS: Surveys were distributed to members of GI surgical societies. Responses were evaluated to define relationships between fellowship training and surgical practice with pancreatoduodenectomy (PD). RESULTS: Surveys were completed by 889 surgeons, 84.1% of whom had completed fellowship training...
October 28, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28027816/pancreatic-anastomosis-after-pancreatoduodenectomy-a-position-statement-by-the-international-study-group-of-pancreatic-surgery-isgps
#5
REVIEW
Shailesh V Shrikhande, Masillamany Sivasanker, Charles M Vollmer, Helmut Friess, Marc G Besselink, Abe Fingerhut, Charles J Yeo, Carlos Fernandez-delCastillo, Christos Dervenis, Christoper Halloran, Dirk J Gouma, Dejan Radenkovic, Horacio J Asbun, John P Neoptolemos, Jakob R Izbicki, Keith D Lillemoe, Kevin C Conlon, Laureano Fernandez-Cruz, Marco Montorsi, Max Bockhorn, Mustapha Adham, Richard Charnley, Ross Carter, Thilo Hackert, Werner Hartwig, Yi Miao, Michael Sarr, Claudio Bassi, Markus W Büchler
BACKGROUND: Clinically relevant postoperative pancreatic fistula (grades B and C of the ISGPS definition) remains the most troublesome complication after pancreatoduodenectomy. The approach to management of the pancreatic remnant via some form of pancreatico-enteric anastomosis determines the incidence and severity of clinically relevant postoperative pancreatic fistula. Despite numerous trials comparing diverse pancreatico-enteric anastomosis techniques and other adjunctive strategies (pancreatic duct stenting, somatostatin analogues, etc), currently, there is no clear consensus regarding the ideal method of pancreatico-enteric anastomosis...
December 24, 2016: Surgery
https://www.readbyqxmd.com/read/27884544/pancreas-fistula-risk-prediction-implications-for-hospital-costs-and-payments
#6
Daniel E Abbott, Ching Wei D Tzeng, Matthew T McMillan, Mark P Callery, Tara S Kent, John D Christein, Stephen W Behrman, Daniel P Schauer, Dennis J Hanseman, Mark H Eckman, Charles M Vollmer
BACKGROUND: As payment models evolve, disease-specific risk stratification may impact patient selection and financial outcomes. This study sought to determine whether a validated clinical risk score for post-operative pancreatic fistula (POPF) could predict hospital costs, payments, and profit margins. METHODS: A multi-institutional cohort of 1193 patients undergoing pancreaticoduodenectomy (PD) were matched to an independent hospital where cost, in US$, and payment data existed...
November 21, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27865280/postpancreatectomy-complications-and-management
#7
REVIEW
Giuseppe Malleo, Charles M Vollmer
Although mortality rates after pancreatectomy have decreased, the incidence of postoperative morbidity remains high. The major procedure-related complications are pancreatic fistula, delayed gastric emptying, and postpancreatectomy hemorrhage. The International Study Group of Pancreatic Surgery defined leading complications in a standardized fashion, allowing unbiased comparison of operative results and management strategies. Risk factors for postoperative complications have been investigated and quantitative scoring systems established to estimate patient-specific risks...
December 2016: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27759781/brazilian-consensus-for-multimodal-treatment-of-colorectal-liver-metastases-module-3-controversies-and-unresectable-metastases
#8
Orlando Jorge Martins Torres, Márcio Carmona Marques, Fabio Nasser Santos, Igor Correia de Farias, Anelisa Kruschewsky Coutinho, Cássio Virgílio Cavalcante de Oliveira, Antonio Nocchi Kalil, Celso Abdon Lopes de Mello, Jaime Arthur Pirola Kruger, Gustavo Dos Santos Fernandes, Claudemiro Quireze, André M Murad, Milton José de Barros E Silva, Charles Edouard Zurstrassen, Helano Carioca Freitas, Marcelo Rocha Cruz, Rui Weschenfelder, Marcelo Moura Linhares, Leonaldson Dos Santos Castro, Charles Vollmer, Elijah Dixon, Héber Salvador de Castro Ribeiro, Felipe José Fernandez Coimbra
In the last module of this consensus, controversial topics were discussed. Management of the disease after progression during first line chemotherapy was the first discussion. Next, the benefits of liver resection in the presence of extra-hepatic disease were debated, as soon as, the best sequence of treatment. Conversion chemotherapy in the presence of unresectable liver disease was also discussed in this module. Lastly, the approach to the unresectable disease was also discussed, focusing in the best chemotherapy regimens and hole of chemo-embolization...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27730401/externalized-stents-for-pancreatoduodenectomy-provide-value-only-in-high-risk-scenarios
#9
Matthew T McMillan, Brett L Ecker, Stephen W Behrman, Mark P Callery, John D Christein, Jeffrey A Drebin, Douglas L Fraker, Tara S Kent, Major K Lee, Robert E Roses, Michael H Sprys, Charles M Vollmer
BACKGROUND: Evidence suggests externalized trans-anastomotic stents may be beneficial as a fistula mitigation strategy for pancreatoduodenectomy (PD); however, previous studies have not been rigorously risk-adjusted. METHODS: From 2001 to 2015, PDs were performed at three institutions, with externalized stents placed at the surgeon's discretion. The Fistula Risk Score (FRS) and the Modified Accordion Severity Grading System were used to analyze occurrence and severity of clinically relevant postoperative pancreatic fistula (CR-POPF) across various risk scenarios...
October 11, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27692778/definition-and-classification-of-chyle-leak-after-pancreatic-operation-a-consensus-statement-by-the-international-study-group-on-pancreatic-surgery
#10
Marc G Besselink, L Bengt van Rijssen, Claudio Bassi, Christos Dervenis, Marco Montorsi, Mustapha Adham, Horacio J Asbun, Maximillian Bockhorn, Oliver Strobel, Markus W Büchler, Olivier R Busch, Richard M Charnley, Kevin C Conlon, Laureano Fernández-Cruz, Abe Fingerhut, Helmut Friess, Jakob R Izbicki, Keith D Lillemoe, John P Neoptolemos, Michael G Sarr, Shailesh V Shrikhande, Robert Sitarz, Charles M Vollmer, Charles J Yeo, Werner Hartwig, Christopher L Wolfgang, Dirk J Gouma
BACKGROUND: Recent literature suggests that chyle leak may complicate up to 10% of pancreatic resections. Treatment depends on its severity, which may include chylous ascites. No international consensus definition or grading system of chyle leak currently is available. METHODS: The International Study Group on Pancreatic Surgery, an international panel of pancreatic surgeons working in well-known, high-volume centers, reviewed the literature and worked together to establish a consensus on the definition and classification of chyle leak after pancreatic operation...
February 2017: Surgery
https://www.readbyqxmd.com/read/27519925/multichannel-cochlear-implant-for-selective-neuronal-activation-and-chronic-use-in-the-free-moving-mongolian-gerbil
#11
Armin Wiegner, Charles G Wright, Maike Vollmer
BACKGROUND: Animal models for chronic multichannel cochlear implant stimulation and selective neuronal activation contribute to a better understanding of auditory signal processing and central neural plasticity. NEW METHOD: This paper describes the design and surgical implantation of a multichannel cochlear implant (CI) system for chronic use in the free-moving gerbil. For chronic stimulation, adult-deafened gerbils were connected to a multichannel commutator that allowed low resistance cable rotation and stable electric connectivity to the current source...
August 9, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27497827/comparing-american-gastroenterological-association-pancreatic-cyst-management-guidelines-with-fukuoka-consensus-guidelines-as-predictors-of-advanced-neoplasia-in-patients-with-suspected-pancreatic-cystic-neoplasms
#12
Gene K Ma, David S Goldberg, Nikhil Thiruvengadam, Vinay Chandrasekhara, Michael L Kochman, Gregory G Ginsberg, Charles M Vollmer, Nuzhat A Ahmad
BACKGROUND: In 2015, the American Gastroenterological Association (AGA) published guidelines to provide recommendations for management of suspected pancreatic cystic neoplasms (PCNs). The aim of this study was to compare efficacy of these with the Fukuoka consensus guidelines in predicting advanced neoplasia (AN) in patients with suspected PCNs. STUDY DESIGN: We performed a retrospective study of 239 patients who underwent surgical resection for suspected mucinous PCN at a tertiary care center from 2000 to 2014...
November 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27485065/trends-in-the-scientific-program-of-the-americas-hepato-pancreato-biliary-association-ahpba-annual-meeting-over-the-past-decade-the-more-things-change-the-more-they-stay-the-same
#13
Chad G Ball, Elijah Dixon, Charles M Vollmer
BACKGROUND: Numerous clinical and basic science innovations have been presented at the AHPBA. The objective was to define changes in content and methodology of the scientific program over the past decade. METHODS: AHPBA abstracts from the past 10-years were reviewed by 2 investigators (volume, content, origin, methodology). RESULTS: Of 2194 total AHPBA abstracts (2005-2015), the volume per year decreased over time (2005 = 283; 2015 = 177; p < 0...
August 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27280502/multicenter-prospective-trial-of-selective-drain-management-for-pancreatoduodenectomy-using-risk-stratification
#14
Matthew T McMillan, Giuseppe Malleo, Claudio Bassi, Valentina Allegrini, Luca Casetti, Jeffrey A Drebin, Alessandro Esposito, Luca Landoni, Major K Lee, Alessandra Pulvirenti, Robert E Roses, Roberto Salvia, Charles M Vollmer
OBJECTIVE: This multicenter study sought to prospectively evaluate a drain management protocol for pancreatoduodenectomy (PD). BACKGROUND: Recent evidence suggests value for both selective drain placement and early drain removal for PD. Both strategies have been associated with reduced rates of clinically relevant pancreatic fistula (CR-POPF)-the most common and morbid complication after PD. METHODS: The protocol was applied to 260 consecutive PDs performed at two institutions over 17 months...
June 24, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27232260/incorporation-of-procedure-specific-risk-into-the-acs-nsqip-surgical-risk-calculator-improves-the-prediction-of-morbidity-and-mortality-after-pancreatoduodenectomy
#15
Matthew T McMillan, Valentina Allegrini, Horacio J Asbun, Chad G Ball, Claudio Bassi, Joal D Beane, Stephen W Behrman, Adam C Berger, Mark Bloomston, Mark P Callery, John D Christein, Euan Dickson, Elijah Dixon, Jeffrey A Drebin, Carlos Fernandez-Del Castillo, William E Fisher, Zhi Ven Fong, Ericka Haverick, Robert H Hollis, Michael G House, Steven J Hughes, Nigel B Jamieson, Tara S Kent, Stacy J Kowalsky, John W Kunstman, Giuseppe Malleo, Amy L McElhany, Ronald R Salem, Kevin C Soares, Michael H Sprys, Vicente Valero, Ammara A Watkins, Christopher L Wolfgang, Amer H Zureikat, Charles M Vollmer
OBJECTIVE: This multicenter study sought to evaluate the accuracy of the American College of Surgeons National Surgical Quality Improvement Program's (ACS-NSQIP) surgical risk calculator for predicting outcomes after pancreatoduodenectomy (PD) and to determine whether incorporating other factors improves its predictive capacity. BACKGROUND: The ACS-NSQIP surgical risk calculator has been proposed as a decision-support tool to predict complication risk after various operations...
May 26, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27043078/laparoscopic-versus-open-distal-pancreatectomy-for-pancreatic-cancer
#16
REVIEW
Deniece Riviere, Kurinchi Selvan Gurusamy, David A Kooby, Charles M Vollmer, Marc G H Besselink, Brian R Davidson, Cornelis J H M van Laarhoven
BACKGROUND: Surgical resection is currently the only treatment with the potential for long-term survival and cure of pancreatic cancer. Surgical resection is provided as distal pancreatectomy for cancers of the body and tail of the pancreas. It can be performed by laparoscopic or open surgery. In operations on other organs, laparoscopic surgery has been shown to reduce complications and length of hospital stay as compared with open surgery. However, concerns remain about the safety of laparoscopic distal pancreatectomy compared with open distal pancreatectomy in terms of postoperative complications and oncological clearance...
April 4, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26856699/highly-accurate-sequencing-of-full-length-immune-repertoire-amplicons-using-tn5-enabled-and-molecular-identifier-guided-amplicon-assembly
#17
Charles Cole, Roger Volden, Sumedha Dharmadhikari, Camille Scelfo-Dalbey, Christopher Vollmers
Ab repertoire sequencing is a powerful tool to analyze the adaptive immune system. To sequence entire Ab repertoires, amplicons are created from Ab H chain (IgH) transcripts and sequenced on a high-throughput sequencer. The field of immune repertoire sequencing is growing rapidly and the protocols used are steadily improving; however, thus far, immune repertoire sequencing protocols have not been able to sequence full-length immune repertoires including the entire IgH V region and enough of the IgH C region to identify isotype subtypes...
March 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26818517/neuropeptide-y-impairs-retrieval-of-extinguished-fear-and-modulates-excitability-of-neurons-in-the-infralimbic-prefrontal-cortex
#18
Lauren L Vollmer, Sarah Schmeltzer, Jennifer Schurdak, Rebecca Ahlbrand, Jennifer Rush, Charles M Dolgas, Mark L Baccei, Renu Sah
UNLABELLED: Neuropeptide Y (NPY), a 36 aa peptide, regulates stress and emotional behaviors. Preclinical and clinical studies support an association of NPY with trauma-evoked syndromes such as posttraumatic stress disorder (PTSD), although the exact contribution of NPY is not clear. In the current study, we examined functional attributes of NPY in the infralimbic (IL) cortex, an area that regulates fear memories and is reported to be hypoactive in PTSD. Carriers of NPY gene polymorphism rs16147 have been reported to have elevated prefrontal NPY expression...
January 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26727086/risk-adjusted-outcomes-of-clinically-relevant-pancreatic-fistula-following-pancreatoduodenectomy-a-model-for-performance-evaluation
#19
Matthew T McMillan, Sameer Soi, Horacio J Asbun, Chad G Ball, Claudio Bassi, Joal D Beane, Stephen W Behrman, Adam C Berger, Mark Bloomston, Mark P Callery, John D Christein, Elijah Dixon, Jeffrey A Drebin, Carlos Fernandez-Del Castillo, William E Fisher, Zhi Ven Fong, Michael G House, Steven J Hughes, Tara S Kent, John W Kunstman, Giuseppe Malleo, Benjamin C Miller, Ronald R Salem, Kevin Soares, Vicente Valero, Christopher L Wolfgang, Charles M Vollmer
OBJECTIVE: To evaluate surgical performance in pancreatoduodenectomy using clinically relevant postoperative pancreatic fistula (CR-POPF) occurrence as a quality indicator. BACKGROUND: Accurate assessment of surgeon and institutional performance requires (1) standardized definitions for the outcome of interest and (2) a comprehensive risk-adjustment process to control for differences in patient risk. METHODS: This multinational, retrospective study of 4301 pancreatoduodenectomies involved 55 surgeons at 15 institutions...
August 2016: Annals of Surgery
https://www.readbyqxmd.com/read/26620704/clinical-metagenomic-identification-of-balamuthia-mandrillaris-encephalitis-and-assembly-of-the-draft-genome-the-continuing-case-for-reference-genome-sequencing
#20
Alexander L Greninger, Kevin Messacar, Thelma Dunnebacke, Samia N Naccache, Scot Federman, Jerome Bouquet, David Mirsky, Yosuke Nomura, Shigeo Yagi, Carol Glaser, Michael Vollmer, Craig A Press, Bette K Kleinschmidt-DeMasters, Bette K Klenschmidt-DeMasters, Samuel R Dominguez, Charles Y Chiu
BACKGROUND: Primary amoebic meningoencephalitis (PAM) is a rare, often lethal, cause of encephalitis, for which early diagnosis and prompt initiation of combination antimicrobials may improve clinical outcomes. METHODS: In this study, we sequenced a full draft assembly of the Balamuthia mandrillaris genome (44.2 Mb in size) from a rare survivor of PAM, and recovered the mitochondrial genome from six additional Balamuthia strains. We also used unbiased metagenomic next-generation sequencing (NGS) and SURPI bioinformatics analysis to diagnose an ultimately fatal case of Balamuthia mandrillaris encephalitis in a 15-year-old girl...
December 1, 2015: Genome Medicine
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