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https://www.readbyqxmd.com/read/27897235/stereotactic-body-radiation-therapy-induces-fast-tumor-control-and-symptom-relief-in-patients-with-iliac-lymph-node-metastasis
#1
Zhongqiu Wang, Jing Wang, Hongqing Zhuang, Ping Wang, Zhiyong Yuan
The CyberKnife is a robotic stereotactic body radiotherapy (SBRT) system which has shown promising results for many malignances with good efficacy and low toxicity. This study aims to evaluate the response and local control (LC) obtained with CyberKnife in the management of iliac lymph node metastases (ILNM). Twenty-two patients with 27 ILNM were treated by CyberKnife from May 2010 to May 2016. Median follow-up time was 33 months (8-97). The complete response, partial response, stable disease and progression disease rates were 37...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27675629/the-study-of-efficacy-and-safety-of-robotic-stereotactic-body-radiation-therapy-sbrt-for-locally-hepatocellular-carcinoma-hcc-patients-midterm-results-of-a-multi-institutional-single-arm-phase-2-trial-nct-02363218
#2
P Wang, Y Song, H Zhang, P Liang, X Liu, Z Yuan
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675165/dosimetric-validation-of-robotic-prostate-sbrt-with-simultaneous-integrated-dose-escalation-to-dominant-intraprostatic-lesion-using-a-magnetic-resonance-based-3d-printed-prostate-model-in-an-anthropomorphic-pelvis-phantom
#3
H F Xiang, J Cheng, M Alshammari, C Lee, N B Bloch, S Keohan, C Jaffe, J A Efstathiou, A L Zietman, H M Lu, A E Hirsch
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674166/prostate-specific-antigen-kinetics-after-robotic-radiosurgery-based-stereotactic-body-radiation-therapy-sbrt-the-effect-of-pretreatment-clinical-parameters
#4
S R Blacksburg, M R Witten, A E Katz, C Mendez, A Sanchez, V J Martello, N Russo, J A Haas
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27574585/a-comparison-of-robotic-arm-versus-gantry-linear-accelerator-stereotactic-body-radiation-therapy-for-prostate-cancer
#5
REVIEW
Vladimir Avkshtol, Yanqun Dong, Shelly B Hayes, Mark A Hallman, Robert A Price, Mark L Sobczak, Eric M Horwitz, Nicholas G Zaorsky
Prostate cancer is the most prevalent cancer diagnosed in men in the United States besides skin cancer. Stereotactic body radiation therapy (SBRT; 6-15 Gy per fraction, up to 45 minutes per fraction, delivered in five fractions or less, over the course of approximately 2 weeks) is emerging as a popular treatment option for prostate cancer. The American Society for Radiation Oncology now recognizes SBRT for select low- and intermediate-risk prostate cancer patients. SBRT grew from the notion that high doses of radiation typical of brachytherapy could be delivered noninvasively using modern external-beam radiation therapy planning and delivery methods...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27505612/ultrasound-guided-placement-of-gold-fiducial-markers-for-stereotactic-partial-breast-irradiation
#6
Stephen Seiler, Asal Rahimi, Sadia Choudhery, Dan Garwood, Ann Spangler, Solomon Cherian, Sally Goudreau
OBJECTIVE: A novel technique of placing gold fiducial markers in the breast using ultrasound guidance was developed and performed in 51 of 55 consecutive postlumpectomy patients enrolled in a phase I dose escalation trial of accelerated partial-breast irradiation (APBI) using robotic-based stereotactic body radiation therapy (SBRT). CONCLUSION: All 51 postoperative patients underwent successful fiducial placement without complications. Our technique of placing gold fiducial markers in proximity to the seroma cavity is considered safe and effective for breast cancer patients being treated with APBI using robotic-based SBRT...
September 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27493987/local-coverage-determination-policy-and-the-use-of-stereotactic-body-radiation-therapy-for-prostate-cancer
#7
Bruce L Jacobs, Robert Sunderland, Jonathan Yabes, Joel B Nelson, Amber E Barnato, Justin E Bekelman
INTRODUCTION: Local coverage determinations (LCDs) are local decisions that regulate healthcare coverage. We evaluated the impact of LCDs as well as patient, tumor, and market characteristics on the adoption of stereotactic body radiation therapy (SBRT) for prostate cancer. METHODS: Using Surveillance, Epidemiology, and End Results (SEER)-Medicare, we identified men treated with SBRT, intensity-modulated radiotherapy (IMRT), and robotic prostatectomy. We compared demographics, clinical characteristics, and market factors among these three treatments...
November 2015: Urology Practice
https://www.readbyqxmd.com/read/27489794/proctitis-1-week-after-stereotactic-body-radiation-therapy-for-prostate-cancer-implications-for-clinical-trial-design
#8
Ima Paydar, Robyn A Cyr, Thomas M Yung, Siyuan Lei, Brian Timothy Collins, Leonard N Chen, Simeng Suy, Anatoly Dritschilo, John H Lynch, Sean P Collins
BACKGROUND: Proctitis following prostate cancer radiation therapy is a primary determinant of quality of life (QOL). While previous studies have assessed acute rectal morbidity at 1 month after stereotactic body radiotherapy (SBRT), little data exist on the prevalence and severity of rectal morbidity within the first week following treatment. This study reports the acute bowel morbidity 1 week following prostate SBRT. MATERIALS AND METHODS: Between May 2013 and August 2014, 103 patients with clinically localized prostate cancer were treated with 35-36...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27406743/robotic-ultrasound-guided-sbrt-of-the-prostate-feasibility-with-respect-to-plan-quality
#9
Stefan Gerlach, Ivo Kuhlemann, Philipp Jauer, Ralf Bruder, Floris Ernst, Christoph Fürweger, Alexander Schlaefer
PURPOSE: Advances in radiation therapy delivery systems have enabled motion compensated SBRT of the prostate. A remaining challenge is the integration of fast, non-ionizing volumetric imaging. Recently, robotic ultrasound has been proposed as an intra-fraction image modality. We study the impact of integrating a light-weight robotic arm carrying an ultrasound probe with the CyberKnife system. Particularly, we analyze the effect of different robot poses on the plan quality. METHODS: A method to detect the collision of beams with the robot or the transducer was developed and integrated into our treatment planning system...
July 12, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27289354/translational-and-rotational-localization-errors-in-cone-beam-ct-based-image-guided-lung-stereotactic-radiotherapy
#10
Cristina Garibaldi, Gaia Piperno, Annamaria Ferrari, Alessia Surgo, Matteo Muto, Sara Ronchi, Alessia Bazani, Floriana Pansini, Marta Cremonesi, Barbara Alicja Jereczek-Fossa, Roberto Orecchia
PURPOSE: Accurate localization is crucial in delivering safe and effective stereotactic body radiation therapy (SBRT). The aim of this study was to analyse the accuracy of image-guidance using the cone-beam computed tomography (CBCT) of the VERO system in 57 patients treated for lung SBRT and to calculate the treatment margins. MATERIALS AND METHODS: The internal target volume (ITV) was obtained by contouring the tumor on maximum and mean intensity projection CT images reconstructed from a respiration correlated 4D-CT...
July 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27242962/acute-urinary-morbidity-following-stereotactic-body-radiation-therapy-for-prostate-cancer-with-prophylactic-alpha-adrenergic-antagonist-and-urethral-dose-reduction
#11
Michael C Repka, Shan Guleria, Robyn A Cyr, Thomas M Yung, Harsha Koneru, Leonard N Chen, Siyuan Lei, Brian T Collins, Pranay Krishnan, Simeng Suy, Anatoly Dritschilo, John Lynch, Sean P Collins
BACKGROUND: Stereotactic body radiation therapy (SBRT) delivers high doses of radiation to the prostate while minimizing radiation to the adjacent critical organs. Large fraction sizes may increase urinary morbidity due to unavoidable treatment of the prostatic urethra. This study reports rates of acute urinary morbidity following SBRT for localized prostate cancer with prophylactic alpha-adrenergic antagonist utilization and urethral dose reduction (UDR). METHODS: From April 2013 to September 2014, 102 patients with clinically localized prostate cancer were treated with robotic SBRT to a total dose of 35-36...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27236333/clinical-results-of-mean-gtv-dose-optimized-robotic-guided-sbrt-for-liver-metastases
#12
Nicolaus Andratschke, Alan Parys, Susanne Stadtfeld, Stefan Wurster, Stefan Huttenlocher, Detlef Imhoff, Müjdat Yildirim, Dirk Rades, Claus Michael Rödel, Jürgen Dunst, Guido Hildebrandt, Oliver Blanck
BACKGROUND: We retrospectively evaluated the efficacy and toxicity of gross tumor volume (GTV) mean-dose-optimized and real-time motion-compensated robotic stereotactic body radiation therapy (SBRT) in the treatment of liver metastases. METHODS: Between March 2011 and July 2015, 52 patients were treated with SBRT for a total of 91 liver metastases (one to four metastases per patient) with a median GTV volume of 12 cc (min 1 cc, max 372 cc). The optimization of mean GTV dose was prioritized during treatment planning at the potential cost of planning target volume (PTV) coverage reduction while adhering to safe normal tissue constraints...
2016: Radiation Oncology
https://www.readbyqxmd.com/read/27147318/characteristics-and-performance-of-the-first-commercial-multileaf-collimator-for-a-robotic-radiosurgery-system
#13
Christoph Fürweger, Paulette Prins, Harun Coskan, Ben J M Heijmen
PURPOSE: The "InCise™ multileaf-collimator (MLC)" is the first commercial MLC to be mounted on a robotic SRS/SBRT platform (CyberKnife). The authors assessed characteristics and performance of this novel device in a preclinical five months test period. METHODS: Commissioning beam data were acquired with unshielded diodes. EBT3 radiochromic films were employed for measurement of transmission, leaf/bank position accuracy (garden fence) before and after exercising the MLC, for end-to-end testing and further characterization of the beam...
May 2016: Medical Physics
https://www.readbyqxmd.com/read/26843236/dosimetric-and-delivery-efficiency-investigation-for-treating-hepatic-lesions-with-a-mlc-equipped-robotic-radiosurgery-radiotherapy-combined-system
#14
Lihui Jin, Robert A Price, Lu Wang, Joshua Meyer, James Jiajin Fan, Chang Ming Charlie Ma
PURPOSE: The CyberKnife M6 (CK-M6) Series introduced a multileaf collimator (MLC) for extending its capability from stereotactic radiosurgery/stereotactic radiotherapy (SBRT) to conventionally fractionated radiotherapy. This work is to investigate the dosimetric quality of plans that are generated using MLC-shaped beams on the CK-M6, as well as their delivery time, via comparisons with the intensity modulated radiotherapy plans that were clinically used on a Varian Linac for treating hepatic lesions...
February 2016: Medical Physics
https://www.readbyqxmd.com/read/26836488/real-time-tracking-in-liver-sbrt-comparison-of-cyberknife-and-vero-by-planning-structure-based-%C3%AE-evaluation-and-dose-area-histograms
#15
T Sothmann, O Blanck, K Poels, R Werner, T Gauer
The purpose of this study was to evaluate and compare two clinical tracking systems for radiosurgery with regard to their dosimetric and geometrical accuracy in liver SBRT: the robot-based CyberKnife and the gimbal-based Vero. Both systems perform real-time tumour tracking by correlating internal tumour and external surrogate motion. CyberKnife treatment plans were delivered to a high resolution 2D detector array mounted on a 4D motion platform, with the platform simulating (a) tumour motion trajectories extracted from the corresponding CyberKnife predictor log files and (b) the tumour motion trajectories with superimposed baseline-drift...
February 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/26813044/inter-and-intra-fraction-motion-in-stereotactic-body-radiotherapy-for-spinal-and-paraspinal-tumours-using-cone-beam-ct-and-positional-correction-in-six-degrees-of-freedom
#16
Renee Finnigan, Brock Lamprecht, Tamara Barry, Kimberley Jones, Joshua Boyd, Andrew Pullar, Bryan Burmeister, Matthew Foote
INTRODUCTION: Stereotactic body radiotherapy (SBRT) for spinal tumours delivers high doses per fraction to targets in close proximity to neural tissue. With steep dose gradients, small changes in position can confer significant dosimetric impact on adjacent structures. We analysed positioning error in consecutively treated patients on a strict image-guidance protocol with online correction in 6 degrees of freedom (6-DOF). METHODS: Set-up error, residual error post-correction and intra-fraction motion for 30 courses of spinal SBRT in 27 patients were assessed using cone-beam CT...
February 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/26699309/investigating-the-clinical-advantages-of-a-robotic-linac-equipped-with-a-multileaf-collimator-in-the-treatment-of-brain-and-prostate-cancer-patients
#17
Christopher M McGuinness, Alexander R Gottschalk, Etienne Lessard, Jean L Nakamura, Dilini Pinnaduwage, Jean Pouliot, Colin Sims, Martina Descovich
The purpose of this study was to evaluate the performance of a commercially avail-able CyberKnife system with a multileaf collimator (CK-MLC) for stereotactic body radiotherapy (SBRT) and standard fractionated intensity-modulated radiotherapy (IMRT) applications. Ten prostate and ten intracranial cases were planned for the CK-MLC. Half of these cases were compared with clinically approved SBRT plans generated for the CyberKnife with circular collimators, and the other half were compared with clinically approved standard fractionated IMRT plans generated for conventional linacs...
2015: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/26524087/utilizing-time-driven-activity-based-costing-to-understand-the-short-and-long-term-costs-of-treating-localized-low-risk-prostate-cancer
#18
Aaron A Laviana, Annette M Ilg, Darlene Veruttipong, Hung-Jui Tan, Michael A Burke, Douglas R Niedzwiecki, Patrick A Kupelian, Chris R King, Michael L Steinberg, Chandan R Kundavaram, Mitchell Kamrava, Alan L Kaplan, Andrew K Moriarity, William Hsu, Daniel J A Margolis, Jim C Hu, Christopher S Saigal
BACKGROUND: Given the costs of delivering care for men with prostate cancer remain poorly described, this article reports the results of time-driven activity-based costing (TDABC) for competing treatments of low-risk prostate cancer. METHODS: Process maps were developed for each phase of care from the initial urologic visit through 12 years of follow-up for robotic-assisted laparoscopic prostatectomy (RALP), cryotherapy, high-dose rate (HDR) and low-dose rate (LDR) brachytherapy, intensity-modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT), and active surveillance (AS)...
February 1, 2016: Cancer
https://www.readbyqxmd.com/read/26484307/dosimetric-comparison-of-volumetric-modulated-arc-therapy-with-robotic-stereotactic-radiation-therapy-in-hepatocellular-carcinoma
#19
Eun Kyung Paik, Mi-Sook Kim, Chul Won Choi, Won Il Jang, Sung Hyun Lee, Sang Hyoun Choi, Kum Bae Kim, Dong Han Lee
PURPOSE: To compare volumetric modulated arc therapy of RapidArc with robotic stereotactic body radiation therapy (SBRT) of CyberKnife in the planning and delivery of SBRT for hepatocellular carcinoma (HCC) treatment by analyzing dosimetric parameters. MATERIALS AND METHODS: Two radiation treatment plans were generated for 29 HCC patients, one using Eclipse for the RapidArc plan and the other using Multiplan for the CyberKnife plan. The prescription dose was 60 Gy in 3 fractions...
September 2015: Radiation Oncology Journal
https://www.readbyqxmd.com/read/26335703/dosimetric-comparison-between-3-dimensional-conformal-and-robotic-sbrt-treatment-plans-for-accelerated-partial-breast-radiotherapy
#20
L M Goggin, M Descovich, C McGuinness, S Shiao, J Pouliot, C Park
Accelerated partial breast irradiation is an attractive alternative to conventional whole breast radiotherapy for selected patients. Recently, CyberKnife has emerged as a possible alternative to conventional techniques for accelerated partial breast irradiation. In this retrospective study, we present a dosimetric comparison between 3-dimensional conformal radiotherapy plans and CyberKnife plans using circular (Iris) and multi-leaf collimators. Nine patients who had undergone breast-conserving surgery followed by whole breast radiation were included in this retrospective study...
June 2016: Technology in Cancer Research & Treatment
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