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https://www.readbyqxmd.com/read/28620355/role-of-the-vasopressin-apelin-balance-and-potential-use-of-metabolically-stable-apelin-analogs-in-water-metabolism-disorders
#1
REVIEW
Adrien Flahault, Pierre Couvineau, Rodrigo Alvear-Perez, Xavier Iturrioz, Catherine Llorens-Cortes
Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling body fluid homeostasis and cardiovascular functions. In animal models, experimental data demonstrate that intracerebroventricular injection of apelin into lactating rats inhibits the phasic electrical activity of arginine vasopressin (AVP) neurons, reduces plasma AVP levels, and increases aqueous diuresis. In the kidney, apelin increases diuresis by increasing the renal microcirculation and by counteracting the antidiuretic effect of AVP at the tubular level...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28619276/arginine-vasopressin-relates-with-spatial-learning-and-memory-in-a-mouse-model-of-spinocerebellar-ataxia-type-3
#2
Hong-Bo Jiang, Ai-Lin Du, Hai-Yang Luo, Jun Yang, Xiao-Qiu Luo, Rui-Qing Ma, Chang-He Shi, Yu-Ming Xu
Spinocerebellar ataxia is an inherited neurodegenerative disorder that the most prevalent type is type 3 (SCA3). Arginine vasopressin (AVP) is released within the lateral septum for controlling the learning and memory. This communication studied the effect of AVP on the spatial learning and memory of SCA3 mice. The spatial learning and memory were analyzed by Morris water maze test (MWM), and AVP concentration was measured by radioimmunoassay. The results showed that (Alves et al., 2010) the swimming velocity, distance traveled and latency to the platform of MWM in SCA3 mice were reduced slower than those in WT mice over 4 training days (p<0...
June 6, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28618757/the-effect-of-acetylsalicylic-acid-on-vasopressin-serum-insulin-levels-insulin-resistance-and-biochemical-parameters-in-rats-induced-with-experimental-diabetes-type-2
#3
Serkan Şen, Sefa Çelik
BACKGROUND/AIM: Acetylsalicylic acid (ASA) treatment in diabetic patients is very important owing to the increasing hyperactivity of thrombocytes and atherosclerosis. In several investigations, it was reported that diabetes caused increased coronary artery disease, cerebrovascular disease, and death. In this study, we aimed to investigate the effect of ASA on osmoregulation, glycemic control, and some biochemical parameters in rats induced with experimental diabetes type 2. MATERIALS AND METHODS: Twenty-four rats were randomly divided in four groups: control (I), ASA control (II), diabetic (III), and ASA diabetic (IV)...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28617958/alcohol-consumption-decreases-oxytocin-neurons-in-the-anterior-paraventricular-nucleus-of-the-hypothalamus-in-prairie-voles
#4
J R Stevenson, K A Young, A E Bohidar, L M Francomacaro, T R Fasold, J M Buirkle, J R Ndem, S C Christian
BACKGROUND: Alcohol use disorders are associated with dysfunctional social relationships and stress responses. The neuropeptides oxytocin (OT) and vasopressin (AVP) are known to orchestrate or mediate many aspects of social behavior, stress responses, and ingestive behaviors. Because of the overlap between the effects of alcohol and the roles of oxytocin and vasopressin, we sought to determine if alcohol consumption altered expression of OT and AVP in the paraventricular nucleus of the hypothalamus (PVN), one of the key sites for OT and AVP synthesis...
June 15, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28612147/fluoroscopic-targeting-of-wallstents-and-amplatzer-vascular-plugs-in-sharp-recanalization-of-chronic-venous-occlusions
#5
Minhaj S Khaja, Jeffrey Forris Beecham Chick, Ari D Schuman, Kyle J Cooper, Bill S Majdalany, Wael E Saad, David M Williams
INTRODUCTION/PURPOSE: Sharp recanalization of chronic venous occlusions is usually performed with targeting of wire-capture devices like loop snares or balloons. We describe sharp recanalization of chronic venous occlusions using self-expanding stents and vascular plugs. MATERIAL AND METHODS: We retrospectively reviewed all sharp venous recanalization procedures performed over an 11-month period and found Wallstent and Amplatzer vascular plug (AVP) targeting was performed in 16 patients...
June 13, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28608287/increased-glutamic-acid-decarboxylase-expression-in-the-hypothalamic-suprachiasmatic-nucleus-in-depression
#6
Xueyan Wu, Rawien Balesar, Jing Lu, Sahar Farajnia, Qiongbin Zhu, Manli Huang, Ai-Min Bao
In depression, disrupted circadian rhythms reflect abnormalities in the central circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN). Although many SCN neurons are said to be GABAergic, it was not yet known whether and how SCN GABA changes occur in the SCN in depression. We, therefore, studied GABA in the SCN in relation to the changes in arginine vasopressin (AVP), which is one of the major SCN output systems. Postmortem hypothalamus specimens of 13 subjects suffering from depression and of 13 well-matched controls were collected...
June 12, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28605258/avp-825-a-novel-intranasal-delivery-system-for-low-dose-sumatriptan-powder-in-the-treatment-of-acute-migraine
#7
Stephen Silberstein
Migraine is a common, disabling disorder, and many patients remain dissatisfied with existing treatments. AVP-825 (ONZETRA® Xsail®) is a Breath Powered® exhalation delivery system for low-dose sumatriptan nasal powder (22 mg) that has been recently approved for use in the treatment of acute migraine with or without aura in adults. AVP-825 takes advantage of unique features of nasal anatomy and physiology to avoid limitations typically seen with other types of intranasal medication delivery. Areas covered: This review provides a summary of the pharmacology, clinical efficacy and tolerability of AVP-825 in clinical studies to date and also provides an overview of the unique aspects of the delivery system...
June 12, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28589293/impairment-of-osmotic-challenge-induced-neurohypophyseal-hormones-secretion-in-sepsis-survivor-rats
#8
Nilton Nascimento Santos-Junior, Luís Henrique Angenendt Costa, Carlos Henrique Rocha Catalão, Alexandre Kanashiro, Tarek Sharshar, Maria José Alves Rocha
BACKGROUND/PURPOSE: Recent studies have reported that sepsis survivors show impaired central nervous system functions. The osmoregulation in this post-sepsis condition has not been well investigated. In the present study, we evaluated the secretion of neurohypophyseal hormones, arginine vasopressin (AVP) and oxytocin (OT), and water intake induced by osmotic challenge in survivor rats. METHODS: Wistar rats were submitted to sepsis by cecal ligation and puncture (CLP)...
June 6, 2017: Pituitary
https://www.readbyqxmd.com/read/28583780/-nephrogenic-syndrome-of-inappropriate-antidiuresis-early-diagnosis-avoids-severe-hyponatremia-complications
#9
A Cailleaux, F Mahieu, C Heinrichs, B Adams, K Ismaili, C Brachet
AIM: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare disease characterized by a kidney disability to dilute urine and, as a result, severe recurrent hyponatremia. Due to wide variability in clinical expression, the diagnosis still remains a challenge for clinicians. We report our experience of a case in which NSIAD was diagnosed early. We also stress the importance of early diagnosis and treatment, which protects an infant with NSAID from severe hyponatremia. BACKGROUND: A 1-month-old boy was referred to our hospital for persistent hyponatremia and intense vomiting...
June 2, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28580075/role-of-vasopressin-in-current-anesthetic-practice
#10
REVIEW
Keun Suk Park, Kyung Yeon Yoo
Arginine vasopressin (AVP), also known as antidiuretic hormone, is a peptide endogenously secreted by the posterior pituitary in response to hyperosmolar plasma or systemic hypoperfusion states. When administered intravenously, it causes an intense peripheral vasoconstriction through stimulation of V1 receptors on the vascular smooth muscle. Patients in refractory shock associated with severe sepsis, cardiogenic or vasodilatory shock, or cardiopulmonary bypass have inappropriately low plasma levels of AVP ('relative vasopressin deficiency') and supersensitivity to exogenously-administered AVP...
June 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28579791/color-m-mode-echocardiography-derived-propagation-velocity-of-descending-aorta-decreases-with-aging
#11
Mehmet Yaman, Uğur Arslan, Adil Bayramoğlu, Osman Bektaş, Ahmet Karataş
BACKGROUND: Arterial stiffness (AS) can be determined by some noninvasive tests such as pulse wave velocity (PWV). Atherosclerosis is also detectable by some ultrasonographic techniques such as color M-mode-derived propagation velocity measured along the origin of the descending aorta (AVP). AIM: The aim of the study was to find out a possible relationship between atherosclerosis and AVP and whether AVP can be used as a parameter of AS. MATERIALS AND METHODS: The study group was composed of 134 people from routine screening examination who were ≥40 years old, completely healthy, and without any known disease and use of any drug...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28579251/perinatal-exposure-to-organohalogen-pollutants-decreases-vasopressin-content-and-its-mrna-expression-in-magnocellular-neuroendocrine-cells-activated-by-osmotic-stress-in-adult-rats
#12
Samuel Mucio-Ramírez, Eduardo Sánchez-Islas, Edith Sánchez-Jaramillo, Margarita Currás-Collazo, Victor R Juárez-González, Mhar Y Álvarez-González, L E Orser, Borin Hou, Francisco Pellicer, Prasada Rao S Kodavanti, Martha León-Olea
Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are environmental pollutants that produce neurotoxicity and neuroendocrine disruption. They affect the vasopressinergic system but their disruptive mechanisms are not well understood. Our group reported that rats perinatally exposed to Aroclor-1254 (A1254) and DE-71 (commercial mixtures of PCBs and PBDEs) decrease somatodendritic vasopressin (AVP) release while increasing plasma AVP responses to osmotic activation, potentially emptying AVP reserves required for body-water balance...
June 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28577072/regulation-of-renal-na-k-cl-cotransporters-by-vasopressin
#13
REVIEW
Sebastian Bachmann, Kerim Mutig
Vasopressin (AVP) induces antidiuresis, thus playing an essential role in body water and electrolyte homeostasis. Its antidiuretic effects are mediated chiefly by V2 vasopressin receptors (V2R) expressed along the distal nephron and collecting duct epithelia. NaCl reabsorption in the distal nephron, which includes the thick ascending limb (TAL) and distal convoluted tubule (DCT), largely depends on the activity of two structurally related Na-(K)-Cl cotransporters, NKCC2 in TAL and NCC in DCT. AVP-induced activation of these transporters contributes to urine concentration and renal electrolyte reabsorption...
June 2, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28560103/effects-of-arginine-vasopressin-on-the-urine-proteome-in-rats
#14
Manxia An, Yanying Ni, Xundou Li, Youhe Gao
Biomarkers are the measurable changes associated with a physiological or pathophysiological process. The content of urine frequently changes because it is not controlled by homeostatic mechanisms, and these alterations can be a source of biomarkers. However, urine is affected by many factors. In this study, vasoconstrictor and antidiuretic arginine vasopressin (AVP) were infused into rats using an osmotic pump. The rats' urinary proteome after one week of infusion was analyzed by label-free LC-MS/MS. A total of 408 proteins were identified; among these proteins, eight and 10 proteins had significantly altered expression in the low and high dose groups, respectively, compared with the control group using the one-way ANOVA analysis followed by post hoc analysis with the least significant difference (LSD) test or Dunnett's T3 test...
2017: PeerJ
https://www.readbyqxmd.com/read/28558715/modern-peptide-biomarkers-and-echocardiography-in-cardiac-healthy-haemodialysis-patients
#15
Franz Maximilian Rasche, Stephan Stoebe, Thomas Ebert, Silvana Feige, Andreas Hagendorff, Wilma Gertrud Rasche, Filip Barinka, Volker Busch, Ulrich Sack, Jochen G Schneider, Stephan Schiekofer
BACKGROUND: In this prospective study, we aimed to assess the haemodynamic changes before and after haemodialysis (HD) in cardiac healthy subjects on chronic HD by imaging methods and endocrine markers of fluid balance. METHODS: Mid-regional pro-atrial natriuretic peptide (MR-proANP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), vasopressin (AVP) and copeptin (CT-proAVP), metanephrines and normetanephrines, renin and aldosterone, standard transthoracic echocardiography and diameter of vena cava inferior (VCID) were performed in 20 patients with end stage renal disease (CKD5D) before and after HD and were stratified in residual excretion (RE, less or more 0...
May 30, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28558702/background-anaesthetic-agents-do-not-influence-the-impact-of-arginine-vasopressin-on-haemodynamic-states-and-cerebral-oxygenation-during-shoulder-surgery-in-the-beach-chair-position-a-prospective-single-blind-study
#16
Eun-A Jang, Ji-A Song, Ji Youn Shin, Jae Joon Yoon, Kyung Yeon Yoo, Seongtae Jeong
BACKGROUND: Administration of arginine vasopressin (AVP) is associated with reducing jugular venous (SjvO2) and regional cerebral (rScO2) oxygen saturation under propofol-remifentanil (P/R) anaesthesia. We determined whether background anaesthetics modulate the effect of AVP on cerebral oxygenation and haemodynamics. METHODS: We randomly allocated 60 adult patients scheduled for shoulder surgery in the beach chair position (BCP) into 4 groups, to receive either an intravenous bolus of saline (groups PR-S and SN-S) or 0...
May 30, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28551755/the-role-of-the-oxytocin-arginine-vasopressin-system-in-animal-models-of-autism-spectrum-disorder
#17
Rong Zhang, Xin-Jie Xu, Hong-Feng Zhang, Song-Ping Han, Ji-Sheng Han
The nonapeptides oxytocin (OXT) and arginine vasopressin (AVP) are two key mediators in regulating various aspects of mammalian social behaviours. There are several lines of evidence that genetic variants of the OXT/AVP system exist in autism spectrum disorder (ASD) and that this system is dysfunctional at least in some ASD entities. These findings have stimulated the interest to perform studies testing the potential therapeutic application of OXT/AVP in ASD. In this respect animal models are critical for investigating the pathophysiology and for compound screening leading to new therapeutic approaches...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28541755/epinephrine-but-not-vasopressin-attenuates-the-airway-response-to-anaphylactic-shock-in-rats
#18
Feng Zheng, Ruxandra Copotoiu, Charles Tacquard, Bruno Demoulin, Jean Marc Malinovsky, Bruno Levy, Dan Longrois, Grégoire Barthel, Paul Michel Mertes, François Marchal, Silvia Demoulin-Alexikova, Olivier Collange
PURPOSE: The two life-threatening signs of anaphylactic shock (AS) are severe arterial hypotension and bronchospasm. Guidelines recommend epinephrine as first-line treatment. Arginine vasopressin (AVP) has been proposed as an alternative if epinephrine does not correct arterial hypotension. These two drugs may have beneficial, neutral or deleterious effects on airflow either directly or by modifying factors that regulate vasodilatation and/or edema in the bronchial wall. AIM OF THE STUDY: To compare the effects of epinephrine and AVP on airflow and airway leakage in a rat model of AS...
April 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28504191/lethal-factor-antibodies-contribute-to-lethal-toxin-neutralization-in-recipients-of-anthrax-vaccine-precipitated
#19
Eric K Dumas, Lori Garman, Hannah Cuthbertson, Sue Charlton, Bassam Hallis, Renata J M Engler, Shyamal Choudhari, William D Picking, Judith A James, A Darise Farris
A major difference between two currently licensed anthrax vaccines is presence (United Kingdom Anthrax Vaccine Precipitated, AVP) or absence (United States Anthrax Vaccine Adsorbed, AVA) of quantifiable amounts of the Lethal Toxin (LT) component Lethal Factor (LF). The primary immunogen in both vaccine formulations is Protective Antigen (PA), and LT-neutralizing antibodies directed to PA are an accepted correlate of vaccine efficacy; however, vaccination studies in animal models have demonstrated that LF antibodies can be protective...
May 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28503166/inhibition-of-ectopic-arginine-vasopressin-production-by-phenytoin-in-the-small-cell-lung-cancer-cell-line-lu-165
#20
Takahiro Ohta, Mitsuo Mita, Shigeru Hishinuma, Reiko Ishii-Nozawa, Kazuhisa Takahashi, Masaru Shoji
Phenytoin, a voltage-gated sodium channel (NaV channel) antagonist, reportedly inhibits arginine vasopressin (AVP) release from an isolated rat neurohypophysis. So far, it is uncertain whether phenytoin has a direct action on ectopic AVP-producing neuroendocrine tumors. We studied the effect of phenytoin on the release of copeptin, the C-terminal fragment of pro-AVP, and expression of AVP gene in the human small cell lung cancer cell line Lu-165. Cells were maintained in RPMI1640 medium with 10% fetal bovine serum and were used within the fifth passage...
2017: Frontiers in Endocrinology
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