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https://www.readbyqxmd.com/read/28920920/er-associated-degradation-is-required-for-vasopressin-prohormone-processing-and-systemic-water-homeostasis
#1
Guojun Shi, Diane Somlo, Geun Hyang Kim, Cristina Prescianotto-Baschong, Shengyi Sun, Nicole Beuret, Qiaoming Long, Jonas Rutishauser, Peter Arvan, Martin Spiess, Ling Qi
Peptide hormones are crucial regulators of many aspects of human physiology. Mutations that alter these signaling peptides are associated with physiological imbalances that underlie diseases. However, the conformational maturation of peptide hormone precursors (prohormones) in the ER remains largely unexplored. Here, we report that conformational maturation of proAVP, the precursor for the antidiuretic hormone arginine-vasopressin, within the ER requires the ER-associated degradation (ERAD) activity of the Sel1L-Hrd1 protein complex...
September 18, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28920918/mice-deficient-for-erad-machinery-component-sel1l-develop-central-diabetes-insipidus
#2
Daniel G Bichet, Yoann Lussier
Deficiency of the antidiuretic hormone arginine vasopressin (AVP) underlies diabetes insipidus, which is characterized by the excretion of abnormally large volumes of dilute urine and persistent thirst. In this issue of the JCI, Shi et al. report that Sel1L-Hrd1 ER-associated degradation (ERAD) is responsible for the clearance of misfolded pro-arginine vasopressin (proAVP) in the ER. Additionally, mice with Sel1L deficiency, either globally or specifically within AVP-expressing neurons, developed central diabetes insipidus...
September 18, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28918249/perinatal-depression-and-dna-methylation-of-oxytocin-related-genes-a-study-of-mothers-and-their-children
#3
Leonora King, Stephanie Robins, Gang Chen, Volodymyr Yerko, Yi Zhou, Corina Nagy, Nancy Feeley, Ian Gold, Barbara Hayton, Gustavo Turecki, Phyllis Zelkowitz
The present study investigated the association of perinatal depression (PD) with differential methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin receptor (OXTR) gene and 2 intergenic regions (IGR) between the oxytocin (OXT) and vasopressin (AVP) genes. Maternal PD was assessed at 5 time-points during pregnancy and postpartum. Four groups were established based on Edinburgh Postnatal Depression Scale (EPDS) cut-off scores: no PD, prenatal or postpartum depressive symptoms only and persistent PD (depressive symptoms both prenatally and postpartum)...
September 13, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28918226/chronic-central-oxytocin-infusion-impairs-sociability-in-mandarin-voles
#4
Peirong Du, Zhixiong He, Zhenlu Cai, Xin Hao, Na Dong, Wei Yuan, Wenjuan Hou, Jinfeng Yang, Rui Jia, Faodao Tai
Oxytocin (OT) has been reported to increase social contact, however some studies have related OT to reduced social contact, particularly with unfamiliar individuals. The underlying mechanisms of OT on social contact remain unclear. In this study, male mandarin vole (Microtus mandarinus), a socially monogamous rodent, was used as an animal model in which osmotic minipumps were used to intracerebroventricularly administer two continuous dosages of OT or saline for 12 consecutive days. We examined the effect of long-term OT treatment on social behavior, anxiety levels, and levels of oxytocin, vasopressin (AVP) and dopamine (DA) receptors, mRNA expression in the nucleus accumbens (NAcc), and medial amygdala (MeA)...
September 13, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28882471/arginine-vasopressin-improves-the-memory-deficits-in-han-chinese-patients-with-first-episode-schizophrenia
#5
Cai-Hong Geng, Chao Wang, Jun Yang, Hua Wang, Rui-Qing Ma, Xu Liu, Chang-Hong Wang
The memory impairment is a core deficit in the first-episode schizophrenia patients. Arginine vasopressin (AVP) in the brain can improve learning and memory. We performed multicentre, randomized, double-blind, placebo-controlled, parallel-group clinical trial to study the cognitive functioning in Han Chinese first-episode schizophrenic patients in a 12-week treatment regime with the intranasal administration of AVP (128 cases) or placebo (131 cases) in addition to the conventional treatment. The methods of positive and negative syndrome scale (PANSS), Wechsler memory scale-4th edition (WMS-IV) and event-related potential (ERP) were used to study the effects of AVP on the cognitive function...
September 4, 2017: Peptides
https://www.readbyqxmd.com/read/28880380/faster-improvement-in-migraine-pain-intensity-and-migraine-related-disability-at-early-time-points-with-avp-825-sumatriptan-nasal-powder-delivery-system-versus-oral-sumatriptan-a-comparative-randomized-clinical-trial-across-multiple-attacks-from-the-compass
#6
Richard B Lipton, James S McGinley, Kenneth J Shulman, R J Wirth, Dawn C Buse
BACKGROUND: Fast relief of migraine pain, associated symptoms, and migraine-related disability are priorities in the acute treatment of migraine. Efforts to improve the pharmacokinetic profiles of acute migraine treatments with the aim of providing faster relief include the development of non-oral routes of administration. AVP-825 (ONZETRA(®) Xsail(®) ) is a delivery system containing 22 mg sumatriptan powder that uses a patient's own breath to deliver medication intranasally, targeting the upper posterior nasal cavity beyond the narrow nasal valve, an area lined with vascular mucosa conducive to rapid drug absorption into the systemic circulation...
September 7, 2017: Headache
https://www.readbyqxmd.com/read/28877928/anthrax-vaccine-precipitated-induces-edema-toxin-neutralizing-edema-factor-specific-antibodies-in-human-recipients
#7
Eric K Dumas, Timothy Gross, Jason Larabee, Lance Pate, Hannah Cuthbertson, Sue Charlton, Bassam Hallis, Renata J M Engler, Limone C Collins, Christina E Spooner, Hua Chen, Jimmy Ballard, Judith A James, A Darise Farris
Edema Toxin (ET), composed of Edema Factor (EF) and Protective Antigen (PA), is a virulence factor of Bacillus anthracis that alters host immune cell function and contributes to anthrax disease. Anthrax Vaccine Precipitated (AVP) contains low but detectable EF and can elicit EF-specific antibodies in human recipients of AVP. Active and passive vaccination of mice with EF can contribute to protection from challenge with Bacillus anthracis spores or ET. This study compared humoral responses to ET in recipients of AVP (n=33) versus Anthrax Vaccine Adsorbed (AVA; n=66) matched for number of vaccinations and time post-vaccination and furthermore determined whether EF antibodies elicited by AVP contribute to ET neutralization...
September 6, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28877880/altered-vasopressin-and-natriuretic-peptide-levels-in-a-rat-model-of-spinal-cord-injury-implications-for-the-development-of-polyuria
#8
Lynnette R Montgomery, Charles H Hubscher
Urinary dysfunction is a common complaint following spinal cord injury (SCI), and is a leading issue for individuals with SCI that impacts their quality of life. One urinary complication that has received little attention is SCI-induced polyuria, even though SCI individuals will significantly restrict their fluid intake to decrease urine production leading to a sequelae of medical complications. Understanding the mechanisms instigating the development of polyuria will allow us to target interventions which may alleviate polyuria symptoms leading to significant improvements in the quality of life and urinary health of SCI individuals...
September 6, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28871239/arginine-vasopressin-effects-on-subjective-judgments-and-neural-responses-to-same-and-other-sex-faces-in-men-and-women
#9
James K Rilling, Ting Li, Xiangchuan Chen, Pritam Gautam, Ebrahim Haroon, Richmond R Thompson
Arginine vasopressin (AVP) influences social and emotional behaviors across a wide range of species. In humans, intranasal AVP has been previously shown to alter physiological responses to and subjective judgments of same-sex faces in both men and women. The present study attempted to elucidate the neural mechanism for these effects by randomizing 40 healthy men and 40 healthy women to treatment with either 40 IU intranasal AVP or a saline placebo approximately 30 min before imaging their brain function with fMRI as they viewed same and other-sex faces...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28868296/hemodialysis-arteriovenous-access-occlusion-using-the-amplatzer-vascular-plug-in-patients-with-intractable-arm-edema
#10
Michele Di Filippo, Danilo Barbarisi, Doriana Ferrara, Stefania Brancaccio, Luca Del Guercio, Renata Bracale, Alfredo Capuano, Giovanni Esposito, Umberto Marcello Bracale
OBJECTIVES: Vascular occlusion of hemodialysis arteriovenous access (AVA) using an Amplatzer vascular plug (AVP; St. Jude Medical, St. Paul, MN, USA) is an arising and alternative practice in selected patients; however, few reported cases can be found in the literature. Herein, we report on our experience with endovascular treatment of complicated AVA. MATERIALS AND METHODS: From September 2015 to December 2016, 3 patients at our clinic underwent an occlusion of hemodialysis AVA with 2 different Amplatzer vascular plugs: 2 patients with type II and 1 patient with type IV...
May 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/28865986/validation-of-salivary-oxytocin-and-vasopressin-as-biomarkers-in-domestic-dogs
#11
Evan L MacLean, Laurence R Gesquiere, Nancy Gee, Kerinne Levy, W Lance Martin, C Sue Carter
BACKGROUND: Oxytocin (OT) and Vasopressin (AVP) are phylogenetically conserved neuropeptides with effects on social behavior, cognition and stress responses. Although OT and AVP are most commonly measured in blood, urine and cerebrospinal fluid (CSF), these approaches present an array of challenges including concerns related to the invasiveness of sample collection, the potential for matrix interference in immunoassays, and whether samples can be collected at precise time points to assess event-linked endocrine responses...
August 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28865453/arginine-vasopressin-altered-the-expression-of-monocarboxylate-transporters-in-cultured-astrocytes-isolated-from-stroke-prone-spontaneously-hypertensive-rats-and-congenic-shrpch1_18-rats
#12
Kazuo Yamagata, Natsumi Takahashi, Nozomi Akita, Toru Nabika
BACKGROUND: Astrocytes support a range of brain functions as well as neuronal survival, but their detailed relationship with stroke-related edema is not well understood. We previously demonstrated that the release of lactate from astrocytes isolated from stroke-prone spontaneously hypertensive rats (SHRSP/Izm) was attenuated under stroke conditions. The supply of lactate to neurons is regulated by astrocytic monocarboxylate transporters (MCTs). The purpose of this study was to examine the contributions of arginine vasopressin (AVP) and/or hypoxia and reoxygenation (H/R) to the regulation of MCTs and neurotrophic factor in astrocytes obtained from SHRSP/Izm and congenic SHRpch1_18 rats...
September 2, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28865224/direct-effect-of-hypothalamic-neuropeptides-on-the-release-of-catecholamines-by-adrenal-medulla-in-sheep-study-ex-vivo
#13
D Wrońska, B F Kania, M Błachuta
Stress causes the activation of both the hypothalamic-pituitary-adrenocortical axis and sympatho-adrenal system, thus leading to the release from the adrenal medulla of catecholamines: adrenaline and, to a lesser degree, noradrenaline. It has been established that in addition to catecholamines, the adrenomedullary cells produce a variety of neuropeptides, including corticoliberine (CRH), vasopressin (AVP), oxytocin (OXY) and proopiomelanocortine (POMC) - a precursor of the adrenocorticotropic hormone (ACTH)...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28860458/intracellular-chloride-regulation-in-avp-and-vip-neurons-of-the-suprachiasmatic-nucleus
#14
Nathan J Klett, Charles N Allen
Several reports have described excitatory GABA transmission in the suprachiasmatic nucleus (SCN), the master pacemaker of circadian physiology. However, there is disagreement regarding the prevalence, timing, and neuronal location of excitatory GABA transmission in the SCN. Whether GABA is inhibitory or excitatory depends, in part, on the intracellular concentration of chloride ([Cl(-)]i). Here, using ratiometric Cl(-) imaging, we have investigated intracellular chloride regulation in AVP and VIP-expressing SCN neurons and found evidence suggesting that [Cl(-)]i is higher during the day than during the night in both AVP+ and VIP+ neurons...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28854286/therapeutic-time-window-for-conivaptan-treatment-against-stroke-evoked-brain-edema-and-blood-brain-barrier-disruption-in-mice
#15
Emil Zeynalov, Susan M Jones, J Paul Elliott
BACKGROUND: Ischemic stroke is often complicated by brain edema, disruption of blood-brain barrier (BBB), and uncontrolled release of arginine-vasopressin (AVP). Conivaptan, a V1a and V2 receptor antagonist, reduces brain edema and minimizes damage to the blood-brain barrier after stroke. Most stroke patients do not receive treatment immediately after the onset of brain ischemia. Delays in therapy initiation may worsen stroke outcomes. Therefore, we designed a translational study to explore the therapeutic time window for conivaptan administration...
2017: PloS One
https://www.readbyqxmd.com/read/28852457/syndrome-of-inappropriate-antidiuretic-hormone-associated-with-rectal-small-cell-neuroendocrine-carcinoma-a-case-report
#16
Jeffrey D Howard, Peter G Deveaux
Neuroendocrine tumors can arise from any portion of the gastrointestinal tract including the colon and rectum. In the scope of all colon and rectal malignancies, they are a rare cause of colorectal carcinoma. Relating to their pluripotent neuroendocrine cellular origins these carcinomas can produce a variety of biologically active peptides with several resultant paraneoplastic syndromes. One of these paraneoplastic syndromes is the syndrome of inappropriate antidiuretic hormone (SIADH). In the SIADH, supraphysiologic levels of vasopressin (antidiuretic hormone, AVP) precipitates exorbitant free water retention and resultant electrolyte abnormalities, most notably hyponatremia...
July 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28847141/na%C3%A2-%C2%BA-ca%C3%A2-%C3%A2-%C2%BA-exchanger-2-ncx2-in-the-circadian-clock-of-the-rat-suprachiasmatic-nucleus-colocalization-with-neuropeptides-and-daily-profiles-of-gene-expression-and-protein-levels
#17
Pi-Cheng Cheng, Ya-Shuan Chen, Rong-Chi Huang
The plasmalemmal Na⁺/Ca²⁺ changer (NCX) regulates intracellular Ca²⁺ by exchanging 3 Na⁺ for 1 Ca²⁺ in either the Ca²⁺ exit or Ca²⁺ entry mode. All three NCX isoforms NCX1, NCX2, and NCX3 are expressed in the rat brain, with isoform-specific differential distribution. In the central clock of suprachiasmatic nucleus (SCN), intracellular Ca²⁺ controls the circadian release of major neuropeptides, which are the arginine vasopressin (AVP), vasoactive intestinal peptide (VIP) and gastrin releasing peptide (GRP), and the NCX, most likely NCX1, rapidly clears depolarization-induced somatic Ca²⁺ influx...
August 31, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28842817/methamphetamine-induces-tet1-and-tet3-dependent-dna-hydroxymethylation-of-crh-and-avp-genes-in-the-rat-nucleus-accumbens
#18
Subramaniam Jayanthi, Betina Gonzalez, Michael T McCoy, Bruce Ladenheim, Veronica Bisagno, Jean Lud Cadet
Methamphetamine (METH) addiction is a biopsychosocial disorder that is accompanied by multiple relapses even after prolonged abstinence, suggesting the possibilities of long-lasting maladaptive epigenetic changes in the brain. Here, we show that METH administration produced time-dependent increases in the expression of corticotropin-releasing hormone (Crh/Crf), arginine vasopressin (Avp), and cocaine- and amphetamine-regulated transcript prepropeptide (Cartpt) mRNAs in the rat nucleus accumbens (NAc). Chromatin immunoprecipitation (ChIP) assays revealed that METH increased the abundance of phosphorylated CREB (pCREB) at the promoter of Cartpt but not at Avp or Crh DNA sequences...
August 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28833692/central-angiotensin-1-7-increases-osmotic-thirst
#19
Raoni Conceição Dos-Santos, Lívia da Rocha Natalino Monteiro, Bruno Paes-Leme, Danilo Lustrino, José Antunes-Rodrigues, André Souza Mecawi, Luís Carlos Reis
INTRODUCTION: Angiotensin 1-7 (ANG 1-7) is generated by type 2 angiotensin converting enzyme (ACE 2) and binds to MAS receptor. Although it is well known that angiotensin 1-7 functionally antagonizes the effects of the classical renin-angiotensin system (RAS) in several situations, the role of ANG 1-7 in hydromineral homeostasis is not clear. This study aimed to assess the role of ANG 1-7 on neuroendocrine responses to hyperosmolality in rats. METHODS: Male Wistar rats were divided into the following three groups: control, 24 hours of water deprivation (WD) and 24 hours of salt loading (SL, 1...
August 22, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28821967/effects-of-oxytocin-and-arginine-vasopressin-on-the-proliferation-and-differentiation-of-a-serotonergic-cell-line
#20
Zoya Marinova, Susanne Walitza, Edna Grünblatt
The neuropeptides oxytocin and arginine vasopressin (AVP) are involved in the regulation of social behavior and cognition. The current study analyzed the effect of oxytocin and AVP on proliferation and differentiation of serotonergic neurons (RN46A cells). Oxytocin did not affect, while 5-10 μM AVP decreased RN46A proliferation. Oxytocin did not significantly alter, while 10 μM AVP decreased the number of cells extending neurites. We found divergent effects of oxytocin and AVP in serotonergic neurons, underscoring their functional differences...
August 18, 2017: Journal of Neural Transmission
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