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https://www.readbyqxmd.com/read/27920663/asd-and-genetic-associations-with-receptors-for-oxytocin-and-vasopressin-avpr1a-avpr1b-and-oxtr
#1
Sunday M Francis, Soo-Jeong Kim, Emily Kistner-Griffin, Stephen Guter, Edwin H Cook, Suma Jacob
Background: There are limited treatments available for autism spectrum disorder (ASD). Studies have reported significant associations between the receptor genes of oxytocin (OT) and vasopressin (AVP) and ASD diagnosis, as well as ASD-related phenotypes. Researchers have also found the manipulation of these systems affects social and repetitive behaviors, core characteristics of ASD. Consequently, research involving the oxytocin/vasopressin pathways as intervention targets has increased. Therefore, further examination into the relationship between these neuropeptides and ASD was undertaken...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27917269/ecstasy-mdma-and-its-effects-on-kidneys-and-their-treatment-a-review
#2
REVIEW
Feyza Bora, Fatih Yılmaz, Taner Bora
Ecstasy (MDMA; 3,4-methylenedioxymethylamphetamine) is an illicit drug that has been increasingly abused by young people. Its effects include euphoria, enhanced sociability and heightened mental awareness. These come about via the increase of serotonin in both the central nervous system and the sympathetic nervous system. Despite the drug's prevalent abuse, serious or adverse effects are rare. Due to personal pharmacokinetics, effects from the same dosage vary according to the individual. Fatal instances may include acute hyponatremia, hyperthermia (>42 °C), disseminated intravascular coagulation (DIC) resulting from hyperthermia affecting the kidneys, and non-traumatic rhabdomyolysis...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27899079/vasopressin-related-copeptin-is-a-novel-predictor-of-early-endothelial-dysfunction-in-patients-with-adult-polycystic-kidney-disease
#3
Ismail Kocyigit, Mahmut Ilker Yilmaz, Ozkan Gungor, Eray Eroglu, Aydin Unal, Ozcan Orscelik, Bulent Tokgoz, Murat Sipahioglu, Ahmet Sen, Juan Jesús Carrero, Oktay Oymak, Jonas Axelsson
BACKGROUND: In this study, we examined the relative usefulness of serum copeptin levels as a surrogate marker of vasopressin (AVP) in adult polycystic kidney disease (ADPKD) by correlating it with baseline and longitudinal changes in markers of both renal function and common CVD manifestations (hypertensive vascular disease, atherosclerosis and endothelial dysfunction) that accompany the progression of this disease. METHODS: We studied a cohort of young and otherwise healthy ADPKD patients (n = 235) and measured cardiovascular function using flow-mediation dilatation (FMD), carotid intima media thickness (cIMT) and pulse wave velocity (PWV), as well as serum copeptin (commercial ELISA, a stable marker of AVP activity)...
November 30, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27895565/challenges-to-the-pair-bond-neural-and-hormonal-effects-of-separation-and-reunion-in-a-monogamous-primate
#4
Katie Hinde, Chelsea Muth, Nicole Maninger, Benjamin J Ragen, Rebecca H Larke, Michael R Jarcho, Sally P Mendoza, William A Mason, Emilio Ferrer, Simon R Cherry, Marina L Fisher-Phelps, Karen L Bales
Social monogamy at its most basic is a group structure in which two adults form a unit and share a territory. However, many socially monogamous pairs display attachment relationships known as pair bonds, in which there is a mutual preference for the partner and distress upon separation. The neural and hormonal basis of this response to separation from the adult pair mate is under-studied. In this project, we examined this response in male titi monkeys (Callicebus cupreus), a socially monogamous New World primate...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27881080/genotypic-differences-in-intruder-evoked-immediate-early-gene-activation-in-male-but-not-female-vasopressin-1b-receptor-knockout-mice
#5
Shannah K Witchey, Erica L Stevenson, Heather K Caldwell
BACKGROUND: The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mice, Avp signaling through Avpr1b within the CA2 region of the hippocampus is critical for normal aggressive behaviors and social recognition memory. However, this brain area is just one part of a larger neural circuit that is likely to be impacted in Avpr1b knockout (-/-) mice...
November 24, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27873288/cardioprotective-effect-of-aloe-vera-biomacromolecules-conjugated-with-selenium-trace-element-on-myocardial-ischemia-reperfusion-injury-in-rats
#6
Yang Yang, Ming Yang, Fen Ai, Congxin Huang
The present study was undertaken to evaluate the cardioprotection potential and underlying molecular mechanism afforded by a selenium (Se) polysaccharide (Se-AVP) from Aloe vera in the ischemia-reperfusion (I/R) model of rats in vivo. Myocardial I/R injury was induced by occluding the left anterior descending coronary artery (LAD) for 30 min followed by 2-h continuous reperfusion. Pretreatment with Se-AVP (100, 200, and 400 mg/kg) attenuated myocardial damage, as evidenced by reduction of the infarct sizes, increase in serum and myocardial endogenous antioxidants (superoxide dismutase (SOD), glutathione peroxidase (GSH), and catalase (CAT)), and decrease in the malondialdehyde (MDA) level in the rats suffering I/R injury...
November 21, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27871902/the-effects-of-long-term-estradiol-treatment-on-social-behavior-and-gene-expression-in-adult-female-rats
#7
Alexandra N Garcia, Kelsey Bezner, Christina Depena, Weiling Yin, Andrea C Gore
This study tested the effects of long-term estradiol (E2) replacement on social behavior and gene expression in brain nuclei involved in the regulation of these social behaviors in adult female rats. We developed an ultrasonic vocalization (USV) test and a sociability test to examine communications, social interactions, and social preference, using young adult female cagemates. All rats were ovariectomized (OVX) and implanted with a Silastic capsule containing E2 or vehicle, and housed in same-treatment pairs for a 3-month period...
November 19, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27871026/copeptin-a-potential-endocrine-surrogate-marker-of-cck-4-induced-panic-symptoms
#8
Cüneyt Demiralay, Agorastos Agorastos, Alexander Yassouridis, Holger Jahn, Klaus Wiedemann, Michael Kellner
Intravenous cholecystokinin-tetrapeptide (CCK-4) administration reliably and dose-dependently provokes panic anxiety in man, accompanied by adrenocorticotropic hormone (ACTH) and cortisol release. Preclinical findings suggest that behavioral and endocrine effects of CCK-4 are mediated via corticotropin-releasing hormone (CRH) release. Anxiogenic stimulation of the central CCK-receptors in man was shown to increase as well vasopressin (AVP), which acts synergistically with CRH as pituitary-adrenocortical axis stimulator during stress...
November 8, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27870395/sex-differences-in-associations-of-arginine-vasopressin-and-oxytocin-with-resting-state-functional-brain-connectivity
#9
Leah H Rubin, Li Yao, Sarah K Keedy, James L Reilly, Jeffrey R Bishop, C Sue Carter, Hossein Pournajafi-Nazarloo, Lauren L Drogos, Carol A Tamminga, Godfrey D Pearlson, Matcheri S Keshavan, Brett A Clementz, Scot K Hill, Wei Liao, Gong-Jun Ji, Su Lui, John A Sweeney
Oxytocin (OT) and arginine vasopressin (AVP) exert robust and sexually dimorphic influences on cognition and emotion. How these hormones regulate relevant functional brain systems is not well understood. OT and AVP serum concentrations were assayed in 60 healthy individuals (36 women). Brain functional networks assessed with resting-state functional magnetic resonance imaging (rs-fMRI) were constructed with graph theory-based approaches that characterize brain networks as connected nodes. Sex differences were demonstrated in rs-fMRI...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27862165/grk2-%C3%AE-arrestin-mediates-arginine-vasopressin-induced-cardiac-fibroblast-proliferation
#10
Yunxuan Chen, Feifei Xu, Lingling Zhang, Xiaojun Wang, Yifan Wang, AnthonyYiu-Ho Woo, Weizhong Zhu
Cardiac fibrosis is a pathological feature commonly foundinheartsexposed to hemodynamic orneurohormonal stress. Elevated levels of arginine vasopressin (AVP) are closely associated with the progression ofheart failure and could be an underlyingcauseof cardiac fibrosis. The aim of this study is to characterize the effect of AVP on neonatal rat cardiac fibroblasts (NRCFs) and to illustrate itssignallingmechanism. The proliferative effect of AVP was assessed by methylthiazolyldiphenyl-tetrazoliumassay and 5-bromo-2'-deoxyuridine (BrdU) incorporation assay, and the amounts of cellular signallingproteins α-smooth muscle actin(α-SMA),matrix metalloproteinase (MMP) 2, MMP9, and phosphorylated ERK1/2 were determined by Western blotting...
November 14, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27858118/utility-of-amplatzer-vascular-plug-with-preoperative-common-hepatic-artery-embolization-for-distal-pancreatectomy-with-en-bloc-celiac-axis-resection
#11
Masafumi Toguchi, Masakatsu Tsurusaki, Isao Numoto, Syojiro Hidaka, Miho Yamakawa, Nobuyuki Asato, SungWoon Im, Yukinobu Yagyu, Mitsuru Matsuki, Yoshifumi Takeyama, Takamichi Murakami
PURPOSE: To evaluate the feasibility and safety of the Amplatzer vascular plug (AVP) for preoperative common hepatic embolization (CHA) before distal pancreatectomy with en bloc celiac axis resection (DP-CAR) to redistribute blood flow to the stomach and liver via the superior mesenteric artery (SMA). MATERIALS AND METHODS: Four patients (3 males, 1 female; median age 69 years) with locally advanced pancreatic body cancer underwent preoperative CHA embolization with AVP...
November 17, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27856403/does-the-type-and-size-of-amplatzer-vascular-plug-affect-the-occlusion-time-of-pulmonary-arteriovenous-malformations
#12
Ahmed Kamel Abdel-Aal, Moustafa Omar Massoud, Dina Mahmoud Elantably
PURPOSE: Occlusion time (OT) is an important factor in the treatment of pulmonary arteriovenous malformations (PAVMs) since it can lead to serious complications. The purpose of our study is to calculate the OT of Amplatzer vascular plug (AVP, St Jude Medical), and correlate it to the type of the device used (AVP or AVP 2) and the percent of device oversizing. Technical success rates and complications were also recorded. METHODS: We retrospectively studied a total of 19 patients with 47 PAVMs who received percutaneous transcatheter embolization therapy using either AVP or AVP 2...
November 18, 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27847763/preliminary-experience-with-vascular-plugs-for-parent-artery-occlusion-of-the-carotid-or-vertebral-arteries
#13
Woosung Lee, Yong Sam Shin, Kyung Hyun Kim, Yong Bae Kim, Chang-Ki Hong, Joonho Chung
OBJECTIVE: The purpose of this study was to report the authors' preliminary experience using the Amplatzer Vascular Plug (AVP) (St. Jude Medical, Plymouth, MN, USA) for parent artery occlusion of the internal carotid artery (ICA) or vertebral artery (VA). MATERIALS AND METHODS: Between September 2008 and December 2015, we performed 52 therapeutic parent artery occlusions (PAOs) by an endovascular technique. Among them, 10 patients underwent PAO of the carotid or vertebral arteries using AVPs...
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/27829122/opposite-effects-of-central-oxytocin-and-arginine-vasopressin-on-changes-in-gastric-motor-function-induced-by-chronic-stress
#14
Mehmet Bülbül, Osman Sinen, Burcu Gemici, V Nimet İzgüt-Uysal
Hypothalamic oxytocin (OXT) and arginine vasopressin (AVP) are known to act oppositely on hypothalamic-pituitary-adrenal (HPA) axis, stress response and gastrointestinal (GI) motility. In rodents, exposure to restraint stress (RS) delays gastric emptying (GE), however, repeated exposure to the same stressor (chronic homotypic stress (CHS)), the delayed GE is restored to basal level, while hypothalamic OXT is upregulated. In contrast, when rats are exposed to chronic heterotypic stress (CHeS), these adaptive changes are not observed...
November 6, 2016: Peptides
https://www.readbyqxmd.com/read/27815398/optic-pathway-glioma-volume-predicts-retinal-axon-degeneration-in-neurofibromatosis-type-1
#15
Robert A Avery, Awais Mansoor, Rabia Idrees, Carmelina Trimboli-Heidler, Hiroshi Ishikawa, Roger J Packer, Marius George Linguraru
OBJECTIVE: To determine whether tumor size is associated with retinal nerve fiber layer (RNFL) thickness, a measure of axonal degeneration and an established biomarker of visual impairment in children with optic pathway gliomas (OPGs) secondary to neurofibromatosis type 1 (NF1). METHODS: Children with NF1-OPGs involving the optic nerve (extension into the chiasm and tracts permitted) who underwent both volumetric MRI analysis and optical coherence tomography (OCT) within 2 weeks of each other were included...
December 6, 2016: Neurology
https://www.readbyqxmd.com/read/27810202/detecting-animal-by-product-intake-using-stable-isotope-ratio-mass-spectrometry-irms
#16
D A F da Silva, N P Biscola, L D Dos Santos, M M P Sartori, J C Denadai, E T da Silva, C Ducatti, S D Bicudo, B Barraviera, R S Ferreira
Sheep are used in many countries as food and for manufacturing bioproducts. However, when these animals consume animal by-products (ABP), which is widely prohibited, there is a risk of transmitting scrapie - a fatal prion disease in human beings. Therefore, it is essential to develop sensitive methods to detect previous ABP intake to select safe animals for producing biopharmaceuticals. We used stable isotope ratio mass spectrometry (IRMS) for (13)C and (15)N to trace animal proteins in the serum of three groups of sheep: 1 - received only vegetable protein (VP) for 89 days; 2 - received animal and vegetable protein (AVP); and 3 - received animal and vegetable protein with animal protein subsequently removed (AVPR)...
November 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27807133/serotonin-and-arginine-vasopressin-mediate-sex-differences-in-the-regulation-of-dominance-and-aggression-by-the-social-brain
#17
Joseph I Terranova, Zhimin Song, Tony E Larkin, Nathan Hardcastle, Alisa Norvelle, Ansa Riaz, H Elliott Albers
There are profound sex differences in the incidence of many psychiatric disorders. Although these disorders are frequently linked to social stress and to deficits in social engagement, little is known about sex differences in the neural mechanisms that underlie these phenomena. Phenotypes characterized by dominance, competitive aggression, and active coping strategies appear to be more resilient to psychiatric disorders such as posttraumatic stress disorder (PTSD) compared with those characterized by subordinate status and the lack of aggressiveness...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27803296/homocysteine-deteriorates-intrahepatic-derangement-and-portal-systemic-collaterals-in-cirrhotic-rats
#18
Hung-Chun Tung, Shao-Jung Hsu, Ming-Hung Tsai, Te-Yueh Lin, I-Fang Hsin, Teh-Ia Huo, Fa-Yauh Lee, Hui-Chun Huang, Hsin-Ling Ho, Han-Chieh Lin, Shou-Dong Lee
In liver cirrhosis, the altered levels of vasoactive substances, especially endothelin-1 (ET-1) and nitric oxide (NO) leads to elevated intrahepatic resistance, increased portal-systemic collaterals, and abnormal intra- and extra-hepatic vascular responsiveness. These derangements aggravate portal hypertension-related complications such as gastroesophageal variceal bleeding. Homocysteine, a substance implicated in cardiovascular diseases, has been found with influences on vasoresponsiveness and angiogenesis...
November 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27801846/aqp2-plasma-membrane-diffusion-is-altered-by-the-degree-of-aqp2-s256-phosphorylation
#19
Eva C Arnspang, Frédéric H Login, Jennifer S Koffman, Prabuddha Sengupta, Lene N Nejsum
Fine tuning of urine concentration occurs in the renal collecting duct in response to circulating levels of arginine vasopressin (AVP). AVP stimulates intracellular cAMP production, which mediates exocytosis of sub-apical vesicles containing the water channel aquaporin-2 (AQP2). Protein Kinase A (PKA) phosphorylates AQP2 on serine-256 (S256), which triggers plasma membrane accumulation of AQP2. This mediates insertion of AQP2 into the apical plasma membrane, increasing water permeability of the collecting duct...
October 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27789808/elevation-of-arginine-vasopressin-levels-following-loop-diuretic-therapy-as-a-prognostic-indicator-in-heart-failure
#20
Shuichi Kitada, Shohei Kikuchi, Hiroo Sonoda, Atsuhiro Yoshida, Nobuyuki Ohte
OBJECTIVE: To investigate the association between arginine vasopressin (AVP) levels and loop diuretic (LD) therapy in patients with heart failure and to determine if AVP levels are a prognostic indicator of treatment failure. METHODS: Patients with stable heart failure and reduced (< 40%) left ventricular ejection fraction (LVEF) were divided into those treated with (LD) or without LD (NLD). The LD group was separated into subgroups of high (> 6.5 pg/dl) and low (≤ 6...
October 26, 2016: Journal of International Medical Research
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