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https://www.readbyqxmd.com/read/29438776/quercetin-ameliorates-hfd-induced-nafld-by-promoting-hepatic-vldl-assembly-and-lipophagy-via-the-ire1a-xbp1s-pathway
#1
Xinhong Zhu, Ting Xiong, Peiyi Liu, Xiaoping Guo, Lin Xiao, Feng Zhou, Yuhan Tang, Ping Yao
The consumption of a quercetin-rich diet has been well-established as a feasible method against non-alcoholic fatty liver disease (NAFLD); however, the molecular mechanisms underlying the progression of NAFLD and its intervention by quercetin remain largely obscure. Male Sprague-Dawley rats fed high-fat diet (HFD), and HepG2 cells stimulated with free fatty acid, were treated with quercetin and various pharmacological reagents to explore the effect of signaling pathways involved in endoplasmic reticulum stress on very low-density lipoprotein (VLDL) assembly and lipophagy...
February 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29435234/epizoochorous-dispersal-by-ungulates-depends-on-fur-grooming-and-social-interactions
#2
Océane Liehrmann, Flore Jégoux, Marie-Alice Guilbert, Francis Isselin-Nondedeu, Sonia Saïd, Yann Locatelli, Christophe Baltzinger
The transport phase of the animal-mediated plant dispersal process is critical to dispersal effectiveness as it determines the spatial distribution of the diaspores released and their chance for further recruitment. Assessing this specific phase of the dispersal process generally requires combining diaspore retention times with the associated distances covered. Here, we specifically tested the effect of grooming behavior, interindividual contacts and ungulate fur on diaspore retention times and associated dispersal distances for the hooked diaspores of Xanthium strumarium L...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29433230/in-vitro-digestion-behavior-of-water-in-oil-in-water-emulsions-with-gelled-oil-water-inner-phases
#3
Jonathan Andrade, Amanda J Wright, Milena Corredig
Double emulsions may be able to protect and release in a controlled manner bioactive compounds during digestion of food matrices. It was hypothesized that the physical state and solid content in the inner phases of water-in-oil-in-water (W1/O/W2) emulsions may affect the overall stability and the release behavior of bioactives during in vitro digestion. Therefore, hydrophobic (phytosterols or Vitamin D3) and hydrophilic (Vitamin B12) molecules were incorporated in double emulsions prepared either with a liquid (soybean oil - SO) or oil-fat gel (soybean oil+trimyristin - STO) lipid phase and liquid internal aqueous phase...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29428989/determination-of-oligomers-in-virgin-and-recycled-polyethylene-terephthalate-pet-samples-by-uplc-ms-qtof
#4
Sara Ubeda, Margarita Aznar, Cristina Nerín
An oligomer is a molecule that consists of a few monomer units. It can be formed during polymer manufacturing and also due to polymer degradation processes or even during use conditions. Since oligomers are not included in chemical databases, their identification is a complex process. In this work, the oligomers present in 20 different PET pellet samples have been determined. Two different sample treatment procedures, solvent extraction and total dissolution, were applied in order to select the most efficient one...
February 10, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29420841/daphnia-magna-micrornas-respond-to-nutritional-stress-and-ageing-but-are-not-transgenerational
#5
Jack Hearn, Franklin Wang-Ngai Chow, Harriet Barton, Matthew Tung, Phil Wilson, Mark Blaxter, Amy Buck, Tom J Little
Maternal effects, where the performance of offspring is determined by the condition of their mother, are widespread and may in some cases be adaptive. The crustacean Daphnia magna shows strong maternal effects: offspring size at birth and other proxies for fitness are altered when their mothers are older or when mothers have experienced dietary restriction. The mechanisms for this transgenerational transmission of maternal experience are unknown, but could include changes in epigenetic patterning. MicroRNAs (miRNAs) are regulators of gene expression that have been shown to play roles in intergenerational information transfer, and here we test whether miRNAs are involved in D...
February 8, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29417057/fat-storage-inducing-transmembrane-fit-or-fitm-proteins-are-related-to-lipid-phosphatase-phosphotransferase-enzymes
#6
Matthew Hayes, Vineet Choudhary, Namrata Ojha, John Jh Shin, Gil-Soo Han, George M Carman, Christopher Jr Loewen, William A Prinz, Timothy Levine
Fat storage-inducing transmembrane (FIT or FITM) proteins have been implicated in the partitioning of triacylglycerol to lipid droplets and the budding of lipid droplets from the ER. At the molecular level, the sole relevant interaction is that FITMs directly bind to triacyglycerol and diacylglycerol, but how they function at the molecular level is not known. Saccharomyces cerevisiae has two FITM homologues: Scs3p and Yft2p. Scs3p was initially identified because deletion leads to inositol auxotrophy, with an unusual sensitivity to addition of choline...
December 28, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29414510/adiponectin-as-lncrna-inhibits-adipogenesis-by-transferring-from-nucleus-to-cytoplasm-and-attenuating-adiponectin-mrna-translation
#7
Rui Cai, Yunmei Sun, Naren Qimuge, Guoqiang Wang, Yingqian Wang, Guiyan Chu, Taiyong Yu, Gongshe Yang, Weijun Pang
Adiponectin (AdipoQ) is an adipocyte-derived hormone with positive function on systemic glucose and lipid metabolism. Long noncoding RNA (lncRNA) is emerging as a vital regulator of adipogenesis. However, AdipoQ-related lncRNAs in lipid metabolism have not been explored. Here, AdipoQ antisense (AS) lncRNA was first identified, and we further found that it inhibited adipogenesis. The half-life of AdipoQ AS lncRNA was 10 h, whereas that of AdipoQ mRNA was 4 h. During adipogenic differentiation, AdipoQ AS lncRNA translocated from nucleus to cytoplasm...
January 29, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29409987/decreased-atp-production-and-myocardial-contractile-reserve-in-metabolic-heart-disease
#8
Ivan Luptak, Aaron L Sverdlov, Marcello Panagia, Fuzhong Qin, David R Pimentel, Dominique Croteau, Deborah A Siwik, Joanne S Ingwall, Markus M Bachschmid, James A Balschi, Wilson S Colucci
Metabolic syndrome is a cluster of obesity-related metabolic abnormalities that lead to metabolic heart disease (MHD) with left ventricular pump dysfunction. Although MHD is thought to be associated with myocardial energetic deficiency, two key questions have not been answered. First, it is not known whether there is a sufficient energy deficit to contribute to pump dysfunction. Second, the basis for the energy deficit is not clear. To address these questions, mice were fed a high fat, high sucrose (HFHS) 'Western' diet to recapitulate the MHD phenotype...
January 31, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29409356/therapeutic-potential-of-lentivirus-mediated-glucagon-like-peptide-1-glp-1-gene-therapy-for-diabetes
#9
Hale M Tasyurek, Hasan A Altunbas, Mustafa K Balci, Thomas S Griffith, Salih Sanlioglu
Postprandial glucose-induced insulin secretion from the islets of Langerhans is facilitated by glucagon-like peptide-1 (GLP-1) - a metabolic hormone with insulinotropic properties. Among the variety of effects it mediates, GLP-1 induces delta cell secretion of somatostatin, inhibits alpha cell release of glucagon, reduces gastric emptying, and slows food intake. These events collectively contribute to weight loss over time. During type 2 diabetes (T2DM), however, the incretin response to glucose is reduced and accompanied by a moderate reduction in GLP-1 secretion...
February 6, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29399727/implications-of-lipids-in-neonatal-body-weight-and-fat-mass-in-gestational-diabetic-mothers-and-non-diabetic-controls
#10
REVIEW
Emilio Herrera, Henar Ortega-Senovilla
PURPOSE OF REVIEW: Maternal lipid metabolism greatly changes during pregnancy and we review in this article how they influence fetal adiposity and growth under non-diabetic and gestational diabetic conditions. RECENT FINDINGS: In pregnant women without diabetes (control), maternal glycemia correlates with neonatal glycemia, neonatal body weight and fat mass. In pregnant women with gestational diabetes mellitus (GDM), maternal glucose correlates with neither neonatal glycemia, neonatal birth weight nor fat mass, but maternal triacylglycerols (TAG), non-esterified fatty acids (NEFA) and glycerol do correlate with birth weight and neonatal adiposity...
February 5, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29397895/the-evolving-role-of-pre-pectoral-adm-assisted-implant-based-immediate-breast-reconstruction-following-skin-sparing-mastectomy
#11
Umar Wazir, Kefah Mokbel
INTRODUCTION: The increasing use of acellular dermal matrix (ADM) and fat transfer in the context of breast reconstruction, following skin sparing mastectomy (SSM) for therapeutic and risk reducing purposes, combined with the need to eliminate animation deformities, reduce post-operative dysfunctional pain and the risk of capsular contracture, has prompted surgeons to investigate the possibility of placing the mammary implant over the pectoralis major muscle with complete coverage with ADM thus reviving the pre-pectoral approach which was previously abandoned due to high complications rates and poor aesthetics in the pre-ADM era...
February 2, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29395140/early-life-events-associated-with-first-lactation-performance-in-pasture-based-dairy-herds
#12
G M Chuck, P D Mansell, M A Stevenson, M M Izzo
This was a prospective cohort study to determine how events from birth until first calving affect performance during the first lactation in pasture-based dairy herds in Victoria, Australia. Events during the preweaning (0-84 d), prepubertal (85-473 d), and postpubertal (474-804 d) periods were recorded in 6 herds, and their association with first-lactation 100-d and 250-d total milk, fat, and protein yields was quantified. Predictors of first-lactation performance included passive transfer status as a calf; season of birth; age of dam; the presence or absence of dystocia at the time of the heifer's birth; the presence or absence of preweaning diarrhea; preweaning, prepubertal, and postpubertal average daily weight gain; age at first calving; the presence or absence of periparturient disease at first calving; sex of the first-born calf; the presence or absence of a stillborn calf at the first calving; and requirement of assistance at the first calving...
January 26, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29393666/current-and-future-prospects-for-the-use-of-pulsed-electric-field-in-the-meat-industry
#13
Zuhaib F Bhat, James D Morton, Susan L Mason, Alaa El-Din A Bekhit
Pulsed electric field (PEF) is a novel non-thermal technology that has recently attracted the attention of meat scientists and technologists due to its ability to modify membrane structure and enhance mass transfer. Several studies have confirmed the potential of pulsed electric field for improving meat tenderness in both pre-rigor and post-rigor muscles during aging. However, there is a high degree of variability between studies and the underlying mechanisms are not clearly understood. While some studies have suggested physical disruption as the main cause of PEF induced tenderness, enzymatic nature of the tenderization seems to be the most plausible mechanism...
February 2, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29391014/%C3%AE-tocopherol-and-%C3%AE-carotene-concentrations-in-feed-colostrum-cow-and-calf-serum-in-swedish-dairy-herds-with-high-or-low-calf-mortality
#14
Maria Torsein, Ann Lindberg, Catarina Svensson, Sören Krogh Jensen, Charlotte Berg, Karin Persson Waller
BACKGROUND: A study of herd-level risk factors for calf mortality in large Swedish dairy herds showed low serum concentrations of α-tocopherol and β-carotene in 1-7 day old calves to be more common in high mortality herds. Therefore, we aimed to investigate if calf mortality risk at herd level is associated with concentrations of α-tocopherol and/or β-carotene at individual level in feed, colostrum, cow and calf serum, while controlling for herd level covariates. Inclusion criteria were affiliation to the Swedish official milk recording scheme, herd size of ≥ 120 milking cows/year, calf mortality risk (day 1-90) of at least 6% (high mortality; HM) or less than 1% (low mortality; LM) and located within one of two regions in southern Sweden...
February 1, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29385067/sensing-technologies-for-detection-of-acetone-in-human-breath-for-diabetes-diagnosis-and-monitoring
#15
REVIEW
Valentine Saasa, Thomas Malwela, Mervyn Beukes, Matlou Mokgotho, Chaun-Pu Liu, Bonex Mwakikunga
The review describes the technologies used in the field of breath analysis to diagnose and monitor diabetes mellitus. Currently the diagnosis and monitoring of blood glucose and ketone bodies that are used in clinical studies involve the use of blood tests. This method entails pricking fingers for a drop of blood and placing a drop on a sensitive area of a strip which is pre-inserted into an electronic reading instrument. Furthermore, it is painful, invasive and expensive, and can be unsafe if proper handling is not undertaken...
January 31, 2018: Diagnostics
https://www.readbyqxmd.com/read/29377287/multimodal-assessment-of-orbital-immune-cell-infiltration-and-tissue-remodeling-during-development-of-graves-disease-by-1-h19-f-mri
#16
Ulrich Flögel, Anke Schlüter, Christoph Jacoby, Sebastian Temme, J Paul Banga, Anja Eckstein, Jürgen Schrader, Utta Berchner-Pfannschmidt
PURPOSE: To evaluate key molecular and cellular features of Graves orbitopathy (GO) by simultaneous monitoring of alterations in morphology, inflammatory patterns, and tissue remodeling. METHODS: To this end, we utilized a murine model of GO induced by immunization with a human thyroid-stimulating hormone receptor A-subunit plasmid. Altogether, 52 mice were used: 27 GOs and 25 controls (Ctrl) immunized with β-galactasidose plasmid. From these, 17 GO and 12 Ctrl mice were subjected to multimodal MRI at 9...
January 27, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29370004/plastic-surgeon-led-ultrasound
#17
Georgette Oni, Whitney Chow, Venkat Ramakrishnan, Matthew Griffiths
BACKGROUND: Portable high-frequency ultrasound is a useful adjunct to a plastic surgeon's practice. With a short learning curve, this patient-friendly imaging modality has a variety of uses that aid patient management/treatment plans. The authors describe clinical cases and review the literature regarding ultrasound performed by the surgeon. METHODS: The Sonosite S-Nerve machine with the L25X transducer was used (depth, 4.3 cm). Clinical cases that ordinarily would have been referred to the radiology department were taken from the day-to-day practice of the senior author (M...
February 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29363459/cdna-isolation-and-expression-of-nicotinamide-adenine-dinucleotide-phosphate-dependent-cytochrome-p450-reductase-gene-in-the-chagas-disease-vector-triatoma-infestans
#18
Carla G Grosso, María M Stroppa, Gonzalo M Varela, Beatriz A García
Pyrethroid resistance has been detected in Triatoma infestans (Hemiptera: Reduviidae), which was atributed to target site insensitivity and increased oxidative metabolism of the insecticide by cytochrome P450s. Nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome P450 reductase (CPR) plays an essential role in transferring electrons from NADPH to the P450-substrate complex. In this study, the full length CPR cDNA of T. infestans was isolated and gene expression was determined by quantitative polymerase chain reaction...
January 22, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29362073/periorbital-rejuvenation-with-application-of-fat-transfer
#19
REVIEW
Neophytos C Demetriades, Dilip D Madnani
No abstract text is available yet for this article.
March 2018: Atlas of the Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29362072/autologous-fat-transfer-for-maxillofacial-reconstruction
#20
REVIEW
Ryan M Diepenbrock, J Marshall Green
No abstract text is available yet for this article.
March 2018: Atlas of the Oral and Maxillofacial Surgery Clinics of North America
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