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https://www.readbyqxmd.com/read/29650752/lipid-transfer-proteins-in-the-assembly-of-apob-containing-lipoproteins
#1
Alaa Sirwi, M Mahmood Hussain
A better understanding of intracellular lipoprotein assembly may help identify proteins with important roles in lipid disorders. ApoB-containing lipoproteins are macromolecular lipid and protein micelles that act as specialized transport vehicles for hydrophobic lipids. They are assembled predominantly in enterocytes and hepatocytes to transport dietary and endogenous fat, respectively, to different tissues. Assembly occurs in the endoplasmic reticulum and is dependent on lipid re-synthesis in the endoplasmic reticulum and on a chaperone, namely microsomal triglyceride transfer protein...
April 12, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29618473/il-23r-deficiency-does-not-impact-atherosclerotic-plaque-development-in-mice
#2
Daniel Engelbertsen, Marie A C Depuydt, Robin A F Verwilligen, Sara Rattik, Erik Levinsohn, Andreas Edsfeldt, Felicia Kuperwaser, Petr Jarolim, Andrew H Lichtman
BACKGROUND: Interleukin-23 (IL-23) has been implicated in inflammatory and autoimmune diseases by skewing CD4+ T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of IL-23 receptor (IL-23R)-expressing cells in the atherosclerotic aorta and evaluated the effect of IL-23R deficiency on atherosclerosis development in mice. METHODS AND RESULTS: We used heterozygous Ldlr -/- Il23r e GFP / WT knock-in mice to identify IL-23R-expressing cells by flow cytometry and homozygous Ldlr -/- Il23r e GFP / eGFP ( Ldlr -/- Il23r -/- ) mice to investigate the effect of lack of IL-23R in atherosclerosis...
April 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29616181/heparin-enhanced-harvest-and-decanting-for-autologous-fat-transfer
#3
David Teplica, Brent Robinson
No abstract text is available yet for this article.
February 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29596624/the-potential-of-autologous-fat-transfer-as-a-valuable-tool-for-cosmetic-and-reconstructive-purposes-acknowledged-risks-limitations-and-benefits
#4
Samuel M Lam
No abstract text is available yet for this article.
March 29, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29596574/efficacy-and-safety-of-autologous-fat-transfer-in-facial-reconstructive-surgery-a-systematic-review-and-meta-analysis
#5
Todor K Krastev, Jip Beugels, Juliette Hommes, Andrzej Piatkowski, Irene Mathijssen, Rene van der Hulst
Importance: The use of autologous fat transfer (AFT) or lipofilling for correcting contour deformities is seen as one of the major breakthroughs in reconstructive plastic surgery. Its applications in facial reconstructive surgery have been of particular interest owing to the prospect of achieving autologous reconstruction by a minimally invasive approach. However, its unpredictability and variable degree of resorption have limited its utility and much skepticism still exists regarding its efficacy...
March 29, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29592867/periprostatic-fat-tissue-transciptome-reveals-a-signature-diagnostic-for-high-risk-prostate-cancer
#6
Stefano Mangiola, Ryan Stuchbery, Geoff Macintyre, Michael J Clarkson, Justin S Peters, Anthony J Costello, Christopher M Hovens, Niall M Corcoran
Evidence suggests that altered adipose tissue homeostasis may be an important contributor to the development and/or progression of prostate cancer. In this study we investigated the adipose transcriptional profiles of low- and high-risk disease to determine both prognostic potential and possible biological drivers of aggressive disease. RNA was extracted from periprostatic adipose tissue from patients categorised as having prostate cancer with either a high- or low-risk of progression based on tumour characteristics at prostatectomy and profiled by RNA sequencing...
March 28, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29588915/recurrent-8-year-ongoing-unilateral-breast-seroma-formation-after-pip-implant-removal-a-case-report-and-review-of-the-literature
#7
Sonja Kästner, Felix Julian Paprottka, Phillipp Gonser, Manuel De Villegas López, Kai Oliver Kaye
Late seroma formation is a rare complication after implant-based breast enlargement surgery and even less frequent after implant removal. This case report presents a case of painful recurrent seroma formation after the removal of a ruptured Poly Implants Prothèse implant. A 52-year-old patient presented herself in our clinic with a clinical history of recurrent unilateral seroma of the right breast over a period of 8 years after the initial unilateral implant removal. Removal of the remaining implant and complete bilateral capsulectomy was performed...
January 2018: Surgery Journal
https://www.readbyqxmd.com/read/29587266/overexpression-of-ptpn2-in-visceral-adipose-tissue-ameliorated-atherosclerosis-via-t-cells-polarization-shift-in-diabetic-apoe-mice
#8
Ya Li, Huimin Zhou, Feng Wang, Lu Han, Minghao Liu, Yihui Li, Zhihao Wang, Mengxiong Tang, Wei Zhang, Ming Zhong
BACKGROUND/AIMS: Dysregulated inflammation in adipose tissue, marked by increased pro-inflammatory T-cell accumulation and reduced regulatory T cells (Treg), contributes to diabetes-associated insulin resistance and atherosclerosis. However, the molecular mechanisms underlying T-cell-mediated inflammation in adipose tissue remain largely unknown. METHODS: Sixty apolipoprotein E (ApoE-/-) mice were randomly divided into chow and diabetes groups. Diabetes was induced by a high-fat and high-sugar diet combined with low-dose streptozotocin...
March 21, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29571476/annatto-entrapped-casein-chitosan-complexes-improve-whey-color-quality-after-acid-coagulation-of-milk
#9
Giovana B Celli, Raheleh Ravanfar, Siva Kaliappan, Rohit Kapoor, Alireza Abbaspourrad
A fraction of annatto is often transferred to the whey fluid during Cheddar cheese processing, which negatively impacts the visual and sensory attributes of the resultant whey powder. Alternatives to reduce the color in the powder are still needed. In this study, casein-chitosan complexes were prepared to deliver annatto preferentially to the curd and reduce the amount of carryover colorant in whey powder. These complexes were relatively spherical, with a mean complex diameter of 8.3 ± 1.9 µm, zeta-potential of +39...
July 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29566748/high-salt-diet-exacerbates-colitis-in-mice-by-decreasing-lactobacillus-levels-and-butyrate-production
#10
Pedro M Miranda, Giada De Palma, Viktoria Serkis, Jun Lu, Marc P Louis-Auguste, Justin L McCarville, Elena F Verdu, Stephen M Collins, Premysl Bercik
BACKGROUND: Changes in hygiene and dietary habits, including increased consumption of foods high in fat, simple sugars, and salt that are known to impact the composition and function of the intestinal microbiota, may explain the increase in prevalence of chronic inflammatory diseases. High salt consumption has been shown to worsen autoimmune encephalomyelitis and colitis in mouse models through p38/MAPK signaling pathway. However, the effect of high salt diet (HSD) on gut microbiota and on intestinal immune homeostasis, and their roles in determining vulnerability to intestinal inflammatory stimuli are unknown...
March 22, 2018: Microbiome
https://www.readbyqxmd.com/read/29553977/long-term-fate-of-denervated-skeletal-muscle-after-microvascular-flap-transfer
#11
Hak Chang, SeungHwan Hwang, SooA Lim, SuRak Eo, Kyung Won Minn, Ki Yong Hong
BACKGROUND: Muscle flap is a valuable option in soft tissue reconstruction. Denervated skeletal muscle is known to undergo degeneration. However, information regarding histological and genetic changes in muscle free flap without reinnervation over long-term follow-up remains unclear. METHODS: We collected flap muscles obtained during secondary exploration surgery after more than 15 years of previous muscle free flap without reinnervation. Compared with normal muscle and fat, histomorphometric and gene expression analysis of flap muscle were performed...
March 16, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29547795/effects-of-a-moderate-fat-diet-that-is-enriched-with-fish-oil-on-intestinal-lipid-absorption-in-a-senescence-accelerated-prone-mouse-model
#12
Kazushi Yamamoto, Yui Iwagaki, Kouichi Watanabe, Tomonori Nochi, Hisashi Aso, Tsuyoshi Tsuduki
OBJECTIVES: We examined a moderate-fat (MF) diet that is enriched with fish oil (FO) and assessed whether lipid absorption was inhibited in senescence-accelerated prone mice (SAM-P8). METHODS: All mice (N = 70) were fed a normal diet that contained 4 g soybean oil/100 g of diet for 6 mo and then divided the mice into four groups (n = 10 or 20/group). Mice in the baseline group were euthanized at 6 mo old, those in the control group continued on a normal diet until 15 mo of age, those in the MF diet group switched to an MF diet (8 g soybean oil/100 g of diet) until 15 mo of age, and those in the MF + FO group switched to an MF diet that was enriched with FO (6...
December 2, 2017: Nutrition
https://www.readbyqxmd.com/read/29545532/helminth-infection-protects-against-high-fat-diet-induced-obesity-via-induction-of-alternatively-activated-macrophages
#13
Chien Wen Su, Chih-Yu Chen, Yali Li, Shao Rong Long, William Massey, Deepak Vijaya Kumar, W Allan Walker, Hai Ning Shi
Epidemiological studies indicate an inverse correlation between the prevalence of the so-called western diseases, such as obesity and metabolic syndrome, and the exposure to helminths. Obesity, a key risk factor for many chronic health problems, is rising globally and is accompanied by low-grade inflammation in adipose tissues. The precise mechanism by which helminths modulate metabolic syndrome and obesity is not fully understood. We infected high fat diet (HFD)-induced obese mice with the intestinal nematode parasite Heligmosomoides polygyrus and observed that helminth infection resulted in significantly attenuated obesity...
March 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29540474/-transcription-factor-21-tcf21-promotes-proinflammatory-interleukin-6-expression-and-extracellular-matrix-remodeling-in-visceral-adipose-stem-cells
#14
Takeshi Akama, Tae-Hwa Chun
The visceral (VIS) and subcutaneous (SQ) fat pads are developmentally distinct white adipose tissue depots and contribute differently to inflammation and insulin resistance associated with obesity. The basic helix-loop-helix transcriptional regulator transcription factor 21 (TCF21) is a marker gene for white adipose tissues and is abundantly expressed in VIS-derived adipose stem cells (ASCs), but not in SQ-derived ASCs. However, TCF21's role in regulating fat depot-specific gene expression and function is incompletely understood...
March 14, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29539415/err%C3%AE-preserves-brown-fat-innate-thermogenic-activity
#15
Maryam Ahmadian, Sihao Liu, Shannon M Reilly, Nasun Hah, Weiwei Fan, Eiji Yoshihara, Pooja Jha, C Daniel De Magalhaes Filho, Sandra Jacinto, Andrew V Gomez, Yang Dai, Ruth T Yu, Christopher Liddle, Annette R Atkins, Johan Auwerx, Alan R Saltiel, Michael Downes, Ronald M Evans
Brown adipose tissue (BAT) adaptively transfers energy from glucose and fat into heat by inducing a gene network that uncouples mitochondrial electron transport. However, the innate transcription factors that enable the rapid adaptive response of BAT are unclear. Here, we identify estrogen-related receptor gamma (ERRγ) as a critical factor for maintaining BAT identity. ERRγ is selectively expressed in BAT versus WAT, in which, in the absence of PGC1α, it drives a signature transcriptional network of thermogenic and oxidative genes in the basal (i...
March 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29538638/natural-conception-rates-in-couples-with-unexplained-or-mild-male-subfertility-scheduled-for-fertility-treatment-a-secondary-analysis-of-a-randomized-controlled-trial
#16
R van Eekelen, R I Tjon-Kon-Fat, P M M Bossuyt, N van Geloven, M J C Eijkemans, A J Bensdorp, F van der Veen, B W Mol, M van Wely
STUDY QUESTION: What is the natural conception rate over the course of 12 months in couples with unexplained or mild male subfertility who are scheduled for fertility treatment and have a predicted unfavourable prognosis for natural conception? SUMMARY ANSWER: The natural conception rate over the course of 12 months in couples who were allocated to treatment was estimated to be 24.5% (95% CI: 20-29%). WHAT IS KNOWN ALREADY: After starting treatment, couples often perceive unsuccessful cycles as evidence of definitive failure even though they are still able to conceive naturally in between and after treatment...
March 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29534042/factors-influencing-the-flavour-of-bovine-milk-and-cheese-from-grass-based-versus-non-grass-based-milk-production-systems
#17
REVIEW
Kieran N Kilcawley, Hope Faulkner, Holly J Clarke, Maurice G O'Sullivan, Joseph P Kerry
There has been a surge in interest in relation to differentiating dairy products derived from pasture versus confined systems. The impact of different forage types on the sensory properties of milk and cheese is complex due to the wide range of on farm and production factors that are potentially involved. The main effect of pasture diet on the sensory properties of bovine milk and cheese is increased yellow intensity correlated to β-carotene content, which is a possible biomarker for pasture derived dairy products...
March 13, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29528458/effects-of-low-oxygen-during-chorioallantoic-membrane-development-on-post-hatch-growing-performance-of-broiler-chickens
#18
S Druyan, M Ruzal, D Shinder, A Haron
The prenatal circulatory system is adaptive and capable of plasticity designed for the needs of the growing tissue. When a broiler embryo is faced with hypoxic stress, the process of angiogenesis in tissues begins. Exposure to hypoxic conditions of 17% oxygen during the chorioallantoic membrane (CAM) development (E5 to E12) affected the circulatory system and contributed to an increase in the blood oxygen carrying capacity. The present study aimed to evaluate the effects of hypoxic exposure during CAM development on post-hatch performance of broilers and to examine whether hypoxic exposure improved sustainability of birds exposed to acute heat stress...
March 8, 2018: Poultry Science
https://www.readbyqxmd.com/read/29526535/loss-of-lcat-activity-in-the-golden-syrian-hamster-elicits-pro-atherogenic-dyslipidemia-and-enhanced-atherosclerosis
#19
Zhao Dong, Haozhe Shi, Mingming Zhao, Xin Zhang, Wei Huang, Yuhui Wang, Lemin Zheng, Xunde Xian, George Liu
OBJECTIVE: Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in HDL metabolism but its influence on atherosclerosis remains controversial for decades both in animal and clinical studies. Because lack of cholesteryl ester transfer protein (CETP) is a major difference between murine and humans in lipoprotein metabolism, we aimed to create a novel Syrian Golden hamster model deficient in LCAT activity, which expresses endogenous CETP, to explore its metabolic features and particularly the influence of LCAT on the development of atherosclerosis...
March 8, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29524899/transplacental-transfer-of-persistent-organic-pollutants-in-la-plata-dolphins-pontoporia-blainvillei-cetartiodactyla-pontoporiidae
#20
Ana Paula Moreno Barbosa, Paula Méndez-Fernandez, Patrick Simões Dias, Marcos César Oliveira Santos, Satie Taniguchi, Rosalinda Carmela Montone
Persistent organic pollutants (POPs) accumulate in the fat tissue of living organisms and are found in relatively high concentrations in animals at the top of the food chain, such as dolphins. The ability of these compounds to interact with the endocrine system of marine mammals constitutes a risk for the reproduction and conservation of species. The La Plata dolphin, Pontoporia blainvillei, is exclusive to the southwestern Atlantic Ocean and is classified on the IUCN red list as a vulnerable species. Blubber, liver, kidney and muscle samples from four P...
March 7, 2018: Science of the Total Environment
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