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https://www.readbyqxmd.com/read/29036167/development-and-validation-of-a-protocol-for-optimizing-the-use-of-paraffin-blocks-in-molecular-epidemiological-studies-the-example-from-the-hpv-ahead-study
#1
Marisa Mena, Belen Lloveras, Sara Tous, Johannes Bogers, Fausto Maffini, Nitin Gangane, Rekha Vijay Kumar, Thara Somanathan, Eric Lucas, Devasena Anantharaman, Tarik Gheit, Xavier Castellsagué, Michael Pawlita, Silvia de Sanjosé, Laia Alemany, Massimo Tommasino
Worldwide use of formalin-fixed paraffin-embedded blocks (FFPE) is extensive in diagnosis and research. Yet, there is a lack of optimized/standardized protocols to process the blocks and verify the quality and presence of the targeted tissue. In the context of an international study on head and neck cancer (HNC)-HPV-AHEAD, a standardized protocol for optimizing the use of FFPEs in molecular epidemiology was developed and validated. First, a protocol for sectioning the FFPE was developed to prevent cross-contamination and distributed between participating centers...
2017: PloS One
https://www.readbyqxmd.com/read/29035371/lncrna-mir100hg-derived-mir-100-and-mir-125b-mediate-cetuximab-resistance-via-wnt-%C3%AE-catenin-signaling
#2
Yuanyuan Lu, Xiaodi Zhao, Qi Liu, Cunxi Li, Ramona Graves-Deal, Zheng Cao, Bhuminder Singh, Jeffrey L Franklin, Jing Wang, Huaying Hu, Tianying Wei, Mingli Yang, Timothy J Yeatman, Ethan Lee, Kenyi Saito-Diaz, Scott Hinger, James G Patton, Christine H Chung, Stephan Emmrich, Jan-Henning Klusmann, Daiming Fan, Robert J Coffey
De novo and acquired resistance, which are largely attributed to genetic alterations, are barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate cetuximab-resistant cells, we exposed cetuximab-sensitive colorectal cancer cells to cetuximab in three-dimensional culture. Using whole-exome sequencing and transcriptional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs, miR-100 and miR-125b, were overexpressed in the absence of known genetic events linked to cetuximab resistance...
October 16, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29034444/mage-a11-expression-contributes-to-cisplatin-resistance-in-head-and-neck-cancer
#3
Stefan Hartmann, Leonie Zwick, Mario J J Scheurer, Andreas R Fuchs, Roman C Brands, Axel Seher, Hartmut Böhm, Alexander C Kübler, Urs D A Müller-Richter
OBJECTIVE: The objective of this study is to investigate the roles of melanoma-associated antigens (MAGEs) in the cisplatin treatment of head and neck cancer. MATERIALS AND METHODS: We assessed the efficacy of cisplatin in a set of four head and neck cancer cell lines using a crystal violet assay. The MAGE-A expression in all cell lines was measured with RT-qPCR. The correlation between MAGE-A expression and cisplatin efficacy was investigated using Spearman's correlation analysis...
October 15, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29033672/role-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-the-evaluation-of-head-and-neck-carcinoma
#4
REVIEW
Moheieldin M Abouzied, Ahmed Fathala, Abdulaziz Alsugair, Ahmad I Al Muhaideb, Mohammed H Al Qahtani
Fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET-CT) has been playing a pivotal role in tumor imaging for the past 20 years. Head and neck (HN) cancers are a good example that can illustrate such unique role of FDG imaging contributing to the patient's management. In this review article, we will describe the normal physiological distribution of FDG within HN structures focusing on its limitations and pitfalls. In addition, we will be also describing its role in the initial staging and restaging of the disease, particularly with regard to therapy response assessment...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29032418/transoral-robotic-surgery-for-squamous-cell-carcinomas-of-the-posterior-pharyngeal-wall
#5
B Lallemant, S Moriniere, P Ceruse, M Lebalch, K Aubry, S Hans, G Dolivet, O Malard, Q Bonduelle, S Vergez
Posterior pharyngeal wall squamous cell carcinomas (SCCs) are rare and have an associated poor prognosis. Progress in transoral resection techniques, in particular, transoral robotic surgery (TORS), have renewed the role of surgery in their treatment. This article presents the oncological and functional results obtained by the French Group of Head and Neck Robotic Surgery for TORS for posterior pharyngeal wall SCC-curative surgery. This retrospective, multicentre study presents data collected between September 2009 and November 2013 for patients treated with TORS for posterior pharyngeal wall SCCs...
October 14, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29031904/definitive-radiotherapy-for-a-head-and-neck-merkel-cell-carcinoma-and-comprehensive-nodal-volumes-a-case-for-using-a-computer-designed-variable-thickness-compensator-to-reduce-risk-and-severity-of-mucositis
#6
Anesa Ahamad, Donald T Weed, Darel D Pruett, Daniel Saulpaugh, Womah Neeranjun, Eduardo Fernandez
When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female...
October 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29031365/chapter-3-the-role-of-pet-ct-in-squamous-cell-carcinoma-of-the-head-and-neck
#7
Hrishikesh Kale, Tanya J Rath
Head and neck squamous cell carcinoma is an important cause of cancer morbidity worldwide and has been stratified into human papillomavirus-related and human papillomavirus-unrelated subgroups that affect prognosis and now staging. Conventional anatomical imaging methods are suboptimal for the detection of regional and distant metastases that are important prognosticators associated with poor outcomes. Functional imaging with (F18)-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) is a useful tool in the management of head and neck squamous cell carcinoma, providing complementary physiological and anatomical information...
October 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29031363/chapter-1-neck-anatomy-imaging-based-level-nodal-classification-and-impact-of-primary-tumor-site-on-patterns-of-nodal-metastasis
#8
Matthew H Kulzer, Barton F Branstetter
The anatomy of the neck is complex, with many critical structures crowded together in a relatively small cross-sectional area. Many structures in the neck also have similar soft tissue density or signal that further complicates interpretation for the radiologist, who relies on tissue differences to create contrast resolution and distinguish structures. Head and neck cancer incidence exceeds 550,000 cases per year worldwide, with diagnosis, treatment, and prognosis relying highly on a thorough knowledge of this compact space...
October 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29031310/in-a-bad-place-carers-of-patients-with-head-and-neck-cancer-experiences-of-travelling-for-cancer-treatment
#9
Myles Balfe, Kieran Keohane, Katie O' Brien, Rachael Gooberman-Hill, Rebecca Maguire, Paul Hanly, Eleanor O' Sullivan, Linda Sharp
PURPOSE: To explore the effect that treatment-related commuting has on carers of patients with head and neck cancer. METHOD: Semi-structured interviews, thematically analysed, with 31 carers. RESULTS: Treatment-related commuting had a considerable impact on carers of patients with head and neck cancer, both in practical terms (economic costs, disruption) and also in psychological terms. Many carers of patients with head and neck cancer described becoming distressed by their commute...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29031066/serendipitous-discovery-of-potent-human-head-and-neck-squamous-cell-carcinoma-anti-cancer-molecules-a-fortunate-failure-of-a-rational-molecular-design
#10
Chiara Zagni, Venerando Pistarà, Luciana A Oliveira, Rogerio M Castilho, Giovanni Romeo, Ugo Chiacchio, Antonio Rescifina
Histone deacetylase inhibitors (HDACis) play an important role as valuable drugs targeted to cancer therapy: several HDACis are currently being tested in clinical trials. Two new potential HDACis 1a and 1d, characterized by the presence of a biphenyl-4-sulfonamide group as a connection unit between the N-{4-[(E)-(2-formylhydrazinylidene)methyl]-3-hydroxyphenyl} and the 2-hydroxy-N-(trifluoroacetyl)benzamide moiety, respectively, as two zinc-binding group (ZBG), have been designed, synthesized and tested for their biological activity...
October 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29030020/the-trajectory-of-positive-psychological-change-in-a-head-and-neck-cancer-population
#11
S A Harding
A stressful event may be sufficient to challenge a strongly held set of assumptions about the world and the self. In some people this may lead to post-traumatic stress disorder (PTSD) and in others to positive psychological change (PPC), whereby a person's reactions to the challenge are beneficial. Little research has investigated PPC in people who have had head and neck cancer (HNC). The aim of this study was to identify demographic, clinical, and psychological factors associated with PPC over time. A cross-sequential study collected data over 5 years...
October 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29029988/mandibular-embryonal-rhabdomyosarcoma-with-cartilaginous-metaplasia-report-of-a-case-and-review-of-literature
#12
Scott M Peters, Tim Kunkle, Michael A Perrino, Elizabeth M Philipone, Angela J Yoon
Rhabdomyosarcoma (RMS) is a malignant tumor of skeletal muscle origin and frequently involves the head and neck region. It represents the second most common pediatric soft tissue sarcoma and accounts for 3% of all childhood cancers. Here, we report a case of embryonal RMS presenting as a right-sided facial swelling in a 7-year-old boy. Histologically, the tumor consisted of classic embryonal rhabdosarcomatous areas with metaplastic cartilage, in both initial biopsy and final resection specimens. Cartilaginous metaplasia arising in the background of RMS is a rare finding, thus raising a diagnostic challenge...
September 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29029943/bcg-immune-activation-reduces-growth-and-angiogenesis-in-an-in-vitro-model-of-head-and-neck-squamous-cell-carcinoma
#13
Carolina Sánchez-Rodríguez, Keyliz Peraza Cruces, Juan Riestra Ayora, Eduardo Martín-Sanz, Ricardo Sanz-Fernández
Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide and is associated with poor survival and significant treatment morbidity. The immune profile in patients with HNSCC is immunosuppressive and presents cytokine-mediated adaptive immune responses, triggered apoptosis of T cells, and alterations in antigen processing machinery. Bacille Calmette-Guerin (BCG) immunotherapy has been used successfully as a treatment for several types of cancer. In the present study, we sought to determine the antitumor effect of soluble mediators from peripheral blood mononuclear immune cells (PBMCs) activated with BCG vaccine in a three-dimensional coculture model of HNSCC growth using FaDu hypopharynx carcinoma squamous cells...
October 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29029767/pet-ct-and-pet-mri-in-head-and-neck-malignancy
#14
REVIEW
T A Szyszko, G J R Cook
Combined 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET)/computed tomography (CT) has an established role in the staging of difficult cases of head and neck (HN) squamous cell carcinoma (SCC), looking for an unknown primary, assessing response post-chemotherapy at 3-6 months, and differentiating relapse from treatment effects in patients suspected to have tumour recurrence. The PET NECK trial, comparing PET/CT surveillance versus neck dissection in advanced head and neck cancer showed survival was similar among patients who underwent PET/CT-guided surveillance and those who underwent planned neck dissection, but surveillance was more cost-effective...
October 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29029645/on-the-implications-of-desexualizing-vaccines-against-sexually-transmitted-diseases-reflections-from-a-practicing-pediatrician
#15
Amanda F Dempsey
Human papillomavirus (HPV) vaccination holds great promise for drastically reducing the incidence of HPV-associated cancers of the genital tract, and possibly also certain head and neck cancers. Unfortunately, rates of HPV vaccine utilization among adolescents are low in many countries. Many research studies have identified the fact that HPV is a sexually transmitted infection as a barrier to higher vaccination rates. This is related to providers' and parents' reluctance to discuss or consider the burgeoning sexuality of their child...
October 13, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29029021/aetiological-heterogeneity-of-head-and-neck-squamous-cell-carcinomas-the-role-of-human-papillomavirus-infections-smoking-and-alcohol
#16
Nada J Farsi, Marie-Claude Rousseau, Nicolas Schlecht, Geneviève Castonguay, Paul Allison, Phuc Félix Nguyen-Tan, Denis Soulieres, Francois Coutlée, Michael Hier, Sreenath Madathil, Eduardo L Franco, Belinda Nicolau
Tobacco and alcohol consumption are the main risk factors for head and neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), a subset of HNSCC. We assessed the independent effects of tobacco, alcohol, and HPV infection on OPC risk in the Head and Neck Cancer(HeNCe) Life study, a hospital-based case-control study of HNSCC with frequency-matched controls by age and sex from four Montreal hospitals. Interviewers collected information on socio-demographic and behavioural factors...
September 28, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028842/in-vitro-investigation-of-head-and-neck-cancer-stem-cell-proportions-and-their-changes-following-x-ray-irradiation-as-a-function-of-hpv-status
#17
Paul Reid, Puthenparampil Wilson, Yanrui Li, Loredana G Marcu, Alexander H Staudacher, Michael P Brown, Eva Bezak
INTRODUCTION: Some head and neck squamous cell carcinomas (HNSCC) have a distinct aetiology, which depends on the presence of oncogenic human papilloma virus (HPV). Also, HNSCC contains cancer stem cells (CSCs) that have greater radioresistance and capacity to change replication dynamics in response to irradiation compared to non-clonogenic cells. Since there is limited data on CSCs in HNSCC as a function of HPV status, better understanding of their radiobiology may enable improved treatment outcome...
2017: PloS One
https://www.readbyqxmd.com/read/29028510/comparison-of-virtual-monochromatic-series-iodine-overlay-maps-and-single-energy-ct-equivalent-images-in-head-and-neck-cancer-conspicuity
#18
Michael Kraft, Mohannad Ibrahim, Matthew Spector, Reza Forghani, Ashok Srinivasan
OBJECTIVE: To compare lesion conspicuity amongst DECT monochromatic series (40, 45, 50keV), and single-energy CT (SECT) equivalent images in head and neck squamous cell carcinomas (HNSCC). METHODS: Two readers compared DECT images to 70keV SECT equivalent series in 39 patients with HNSCC on lesion margin, enhancement, and overall conspicuity. RESULTS: The 45keV and 50keV images were significantly better (p-values ≤0.001) than the SECT equivalent in lesion enhancement, margins, and overall conspicuity for both readers...
September 29, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29028221/quality-of-life-and-patient-reported-outcomes-following-proton-radiation-therapy-a-systematic-review
#19
Vivek Verma, Charles B Simone, Mark V Mishra
Background: As costs of cancer care rise, the importance of documenting value in oncology increases. Proton beam radiotherapy (PBT) has the potential to reduce toxicities in cancer patients, but is relatively expensive and unproven. Evaluating quality of life (QOL) and patient-reported outcomes (PROs) is essential to establishing PBT's "value" in oncologic therapy. The goal of this systematic review was to assess QOL and PROs in patients treated with PBT. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic searches were conducted...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29025727/ct-texture-analysis-potentially-predicts-local-failure-in-head-and-neck-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#20
H Kuno, M M Qureshi, M N Chapman, B Li, V C Andreu-Arasa, K Onoue, M T Truong, O Sakai
BACKGROUND AND PURPOSE: The accurate prediction of prognosis and failure is crucial for optimizing treatment strategies for patients with cancer. The purpose of this study was to assess the performance of pretreatment CT texture analysis for the prediction of treatment failure in primary head and neck squamous cell carcinoma treated with chemoradiotherapy. MATERIALS AND METHODS: This retrospective study included 62 patients diagnosed with primary head and neck squamous cell carcinoma who underwent contrast-enhanced CT examinations for staging, followed by chemoradiotherapy...
October 12, 2017: AJNR. American Journal of Neuroradiology
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