Anna Di Maio, Tommaso Nuzzo, Luana Gilio, Marcello Serra, Fabio Buttari, Francesco Errico, Arianna De Rosa, Mario Stampanoni Bassi, Micaela Morelli, Jumpei Sasabe, David Sulzer, Manolo Carta, Diego Centonze, Alessandro Usiello
L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) signalling. Despite their physiological relevance in modulating cerebral activity, serine enantiomers metabolism in Parkinson's disease (PD) remains elusive. Using High-Performance Liquid Chromatography (HPLC), we measured D- and L-serine levels along with other amino acids known to modulate NMDAR function, such as L-glutamate, L-aspartate, D-aspartate, and glycine, in the post-mortem caudate putamen (CPu) and superior frontal gyrus (SFG) of PD patients...
June 17, 2023: Neurobiology of Disease