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Piergiorgio Lochner, Maurizio A Leone, Klaus Fassbender, Roberto Cantello, Lorenzo Coppo, Raffaele Nardone, Gianni Zorzi, Martin Lesmeister, Cristoforo Comi, Francesco Brigo
BACKGROUND AND PURPOSE: Transorbital sonography (TOS) is a promising tool to support the clinical diagnosis of optic neuritis (ON) by showing thickening of optic nerve. In this study, we aimed to define its specific role in follow-up of ON patients. METHODS: We measured ultrasonography parameters and visual acuity (VA) at presentation and after 1 year in 45 patients with newly diagnosed ON. Two vascular sonographers used B-mode TOS to evaluate mean optic nerve diameter (OND) and optic nerve sheath diameter (ONSD)...
November 13, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Vanessa Maria Pfankuche, Ingo Spitzbarth, Stefanie Lapp, Reiner Ulrich, Ulrich Deschl, Arno Kalkuhl, Wolfgang Baumgärtner, Christina Puff
Histiocytic sarcoma represents a rare malignant tumour with a short survival time, indicating the need of novel treatment strategies including oncolytic virotherapy. The underlying molecular mechanisms of viral oncolysis are largely unknown. As cancer in companion animals shares striking similarities with human counterparts, we chose a permanent canine histiocytic sarcoma cell line (DH82 cells) to identify global transcriptome changes following infection with canine distemper virus (CDV), a paramyxovirus closely related to human measles virus...
November 17, 2016: Journal of Cellular and Molecular Medicine
Laís Silveira Costa
The contemporary context of population aging, itsthe population's different health and disease characteristics, and the growing incorporation of technologies by healthcare systems have highlighted the need to adjust the healthcare structure as a whole. The defense of a democratic and sustainable system reveals the importance of understanding how changes in healthcare take place. The current article aims to contribute to the understanding of innovation in healthcare services. The study's results indicate that the existence of certain knowledge gaps means that public policies tend to overlook a whole rangeseries of innovations normally associated with social changes, with a consequentwith an impact on human development, social cohesion, equality, and equity, allcentral issues that are central toin the field of collective public healthcare field...
November 3, 2016: Cadernos de Saúde Pública
Marcela Muñoz-Torrico, Adrian Rendon, Rosella Centis, Lia D'Ambrosio, Zhenia Fuentes, Carlos Torres-Duque, Fernanda Mello, Margareth Dalcolmo, Rogelio Pérez-Padilla, Antonio Spanevello, Giovanni Battista Migliori
The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no review has ever evaluated this topic in a comprehensive manner. Our objective was to review the available evidence on this topic and draw conclusions regarding the future role of the "post-tuberculosis treatment" phase, which will potentially affect several million cases every year...
September 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Raluca M Simons, Jeffrey S Simons, Dawne Olson, Lee Baugh, Vincent Magnotta, Gina Forster
This fMRI study tested a model of combat trauma, posttraumatic stress symptoms (PTSS), alcohol use, and behavioral and neural responses to emotional cues in 100 OIF/OEF/OND veterans. Multilevel structural equation models were tested for left and right dorsal ACC (dACC), rostral ACC (rACC), and amygdala blood-oxygen- level dependent responses during the emotional counting Stroop test and masked faces task. In the Stroop task, combat exposure moderated the effect of combat stimuli resulting in hyperactivation in the rACC and dACC...
November 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
Camila Quartim de Moraes Bruna, Rafael Queiroz de Souza, Irineu Francisco Silva Massaia, Áurea Silveira Cruz, Kazuko Uchikawa Graziano
Objectives: to determine if there are differences on the safety of the preparation of clean surgical instruments using different types of gloves and bare hands and evaluate the microbiological load of these preparations without gloves. Method: laboratory procedure with a pragmatic approach, in which the samples were handled with different types of gloves and bare hands. In addition, cytotoxicity assays were carried out by means of the agar diffusion method. Further samples were subjected to microbiological analysis after being handled without gloves...
October 10, 2016: Revista Latino-americana de Enfermagem
Armando Dos Santos Trettene, Cassiana Mendes Bertoncelo Fontes, Ana Paula Ribeiro Razera, Marcia Ribeiro Gomide
OBJECTIVES: To assess the impact of promoting self-care in nursing workload and associate it to the variables: age, gender, socioeconomic status, education, marital status and number of children of caregivers. METHODS: Prospective study with 31 children and their caregivers. Participants were assessed at two moments, 1st and 2nd hospitalization, the nursing workload was measured by the Nursing Activities Score (NAS). RESULTS: The mean NAS in the 1st hospitalization was 60...
July 2016: Revista da Escola de Enfermagem da U S P
Kátia Sheylla Malta Purim, Luiza DE Martino Cruvinel Borges, Ana Carolina Possebom
Knowledge of the profile and professional integration of new graduates enables adjustments in medical education. This study evaluated 107 graduates from a private institution in the Brazilian South region, using a self-administered electronic questionnaire. There were similar participation of young physicians of both genders and higher male concentration in general surgery. Graduates are inserted in the public and private labor market. Most do extra shifts in emergency services and trauma surgery, where there is greater need for clinical and surgical skills...
July 2016: Revista do Colégio Brasileiro de Cirurgiões
Crystal L Park, Lucy Finkelstein-Fox, David M Barnes, Carolyn M Mazure, Rani Hoff
OBJECTIVES: Because the use of complementary and alternative medicine (CAM) is increasing among veterans, understanding more about the characteristics of veterans who use CAM is increasingly important. Studies reporting on predictors of use almost always discuss CAM in the aggregate, yet each CAM modality represents a unique approach to healthcare, and each may have different correlates as well as different effectiveness. Very little information is available about veterans' use of each distinct modality, and about psychosocial correlates of various forms of CAM use...
October 2016: Complementary Therapies in Medicine
Meghan E McDevitt-Murphy, Matthew T Luciano, Jessica C Tripp, Jasmine E Eddinger
INTRODUCTION: Combat veterans are at increased risk for PTSD and alcohol misuse, and expectancies and motives for drinking may help explain the link between these comorbid issues. This investigation explored the relationships between PTSD symptoms, PTSD-related alcohol expectancies, motives for drinking, and alcohol consumption/misuse. METHOD: 67 veterans of Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) participated in this project...
August 27, 2016: Addictive Behaviors
Matthew T Luciano, Meghan E McDevitt-Murphy
Research indicates that posttraumatic stress disorder (PTSD) is strongly associated with physical health difficulties, and that social support may be protective for both problems. Social support, however, is often broadly conceptualized. The present analysis explores how Veteran-specific social support (during military deployment and postdeployment) may moderate the relationship between PTSD and physical health functioning. Participants were recruited from a VA Medical Center. Self-report data were analyzed from 63 Veterans (17...
September 22, 2016: Journal of Nervous and Mental Disease
Lori A Bastian, Mary A Driscoll, Alicia A Heapy, William C Becker, Joseph L Goulet, Robert D Kerns, Eric C DeRycke, Elliottnell Perez, Shaina M Lynch, Kristin Mattocks, Aimee R Kroll-Desrosiers, Cynthia A Brandt, Melissa Skanderson, Harini Bathulapalli, Sally G Haskell
 Cigarette smokers seeking treatment for chronic pain have higher rates of opioid use than nonsmokers. This study aims to examine whether veterans of Operations Enduring Freedom/Iraqi Freedom/New Dawn (OEF/OIF/OND) who smoke are more likely to receive an opioid prescription than nonsmokers, adjusting for current pain intensity. DESIGN : Cross-sectional analysis of a cohort study of OEF/OIF/OND veterans who had at least one visit to a Veterans Health Administration primary care clinic between 2001 and 2012...
September 21, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
J Simar, M Godet, J-D Hecq, M Closset, P Gillet, C Langhendries, B Bihin, J Jamart, L Galanti
INTRODUCTION: The aim of the study was to investigate the long-term stability of dexamethasone 10mg associated with alizapride 100mg or ondansetron 8mg in 100mL of 0.9% sodium chloride solution stored at 5±3°C. METHOD: Solutions of 0.9% sodium chloride 100mL in polyolefin bags (n=5) containing approximately dexamethasone (DEX) 10mg associated with alizapride (ALI) 100mg or ondansetron (OND) 8mg were prepared under aseptic conditions and stored about 30 days at 5±3°C...
September 12, 2016: Annales Pharmaceutiques Françaises
Jeffrey S Simons, Raluca M Simons, Carol O'Brien, Scott F Stoltenberg, Jessica A Keith, Jaime A Hudson
This study tested the role of affect lability and disinhibition in mediating associations between PTSD symptoms and two forms of alcohol-related problems, dependence syndrome symptoms (e.g., impaired control over consumption) and conduct problems (e.g., assault, risk behaviors). Genotype at the serotonin transporter linked polymorphic region (5-HTTLPR) was hypothesized to moderate associations between traumatic stress and PTSD symptoms. In addition, the study tested whether childhood traumatic stress moderated associations between combat trauma and PTSD symptoms...
September 4, 2016: Addictive Behaviors
Brian Gold, Matthew R Aronoff, Ronald T Raines
Like azides, diazoacetamides undergo 1,3-dipolar cycloadditions with oxanorbornadienes (OND) in a reaction that is accelerated by the relief of strain in the transition state. The cycloaddition of a diazoacetamide with unstrained ethyl 4,4,4-trifluoro-2-butynoate is, however, 35-fold faster than with the analogous OND because of favorable interactions with the fluoro groups. Its rate constant (k = 0.53 M(-1) s(-1) in methanol) is comparable to those of strain-promoted azide-cyclooctyne cycloadditions.
September 16, 2016: Organic Letters
Rosangela Barbiani, Carlise Rigon Dalla Nora, Rafaela Schaefer
OBJECTIVE: to identify and categorize the practices performed by nurses working in Primary Health Care and Family Health Strategy Units in light of responsibilities established by the profession's legal and programmatic frameworks and by the Brazilian Unified Health System. METHOD: a scoping review was conducted in the following databases: LILACS, IBECS, BDENF, CINAHL and MEDLINE, and the Cochrane and SciELO libraries. Original research papers written by nurses addressing nursing practices in the primary health care context were included...
2016: Revista Latino-americana de Enfermagem
Silvia da Silva Santos Passos, Álvaro Pereira, Rosane Gonçalves Nitschke
OBJETIVO: Compreender o relacionamento no quotidiano dos familiares acompanhantes nos cenários de cuidado que se aproximam da metáfora da tribo no ambiente hospitalar. MÉTODO: Estudo qualitativo com dados coletados a partir de entrevistas semiestruturadas e observação com 16 familiares acompanhantes de pessoas hospitalizadas com dependência para o autocuidado. Os dados foram submetidos à análise temática e analisados através da metáfora da tribo proposta pela sociologia compreensiva...
May 2016: Revista da Escola de Enfermagem da U S P
Christie Graf Ribeiro, Ana Tereza Ramos Moreira, José Simão DE Paula Pinto, Osvaldo Malafaia
OBJECTIVE: to create and validate an electronic database in ophthalmology focused on strabismus, to computerize this database in the form of a systematic data collection software named Electronic Protocol, and to incorporate this protocol into the Integrated System of Electronic Protocols (SINPE(c)). METHODS: this is a descriptive study, with the methodology divided into three phases: (1) development of a theoretical ophthalmologic database with emphasis on strabismus; (2) computerization of this theoretical ophthalmologic database using SINPE(c) and (3) interpretation of the information with demonstration of results to validate the protocol...
May 2016: Revista do Colégio Brasileiro de Cirurgiões
Alessandro Trentini, Massimiliano Castellazzi, Carlo Cervellati, Maria Cristina Manfrinato, Carmine Tamborino, Stefania Hanau, Carlo Alberto Volta, Eleonora Baldi, Vladimir Kostic, Jelena Drulovic, Enrico Granieri, Franco Dallocchio, Tiziana Bellini, Irena Dujmovic, Enrico Fainardi
Matrix Metalloproteases (MMPs) and cytokines have been involved in the pathogenesis of multiple sclerosis (MS). However, no studies have still explored the possible associations between the two families of molecules. The present study aimed to evaluate the contribution of active MMP-9, active MMP-2, interleukin- (IL-) 17, IL-18, IL-23, and monocyte chemotactic proteins-3 to the pathogenesis of MS and the possible interconnections between MMPs and cytokines. The proteins were determined in the serum and cerebrospinal fluid (CSF) of 89 MS patients and 92 other neurological disorders (OND) controls...
2016: Disease Markers
Ralph G DePalma, Stuart W Hoffman
Between April 2007 and December 2015, the Veterans Health Administration (VHA) screened one million combat veterans for traumatic brain injury (TBI), among 2.6 million deployed during operations Enduring Freedom, Iraqi Freedom and New Dawn (OEF/OIF/OND). Since 2007, among those reporting, screened and referred for definitive evaluation, approximately 8.4% of these Veterans received a diagnosis of TBI, the majority characterized as mTBI/Concussion (mTBI) and, in great proportion, related to blast exposures. Mild Traumatic brain injury called "a signature injury" is also known as 'the invisible injury' of these conflicts...
August 20, 2016: Behavioural Brain Research
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