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https://www.readbyqxmd.com/read/28698670/urinary-extracellular-domain-of-neurotrophin-receptor-p75-as-a-biomarker-for-amyotrophic-lateral-sclerosis-in-a-chinese-cohort
#1
Rui Jia, Stephanie Shepheard, Jiaoting Jin, Fangfang Hu, Xing Zhao, Li Xue, Li Xiang, Huaguang Qi, Qiumin Qu, Feng Guo, Mary-Louise Rogers, Jingxia Dang
To comprehensively assess whether p75(ECD) in urine could be a candidate biomarker for ALS evaluation. Urine samples were collected from 101 ALS patients, 108 patients with other neurological disease (OND) and 97 healthy controls. 61 ALS patients were followed up with clinical data including ALSFRS-r every 6 to 12 months, 23 ALS patients died and 17 ALS patients lost touch during follow up period. Enzyme-linked immunoassay was employed to determine urine p75(ECD) concentration. The ALSFRS-r was employed to assess the severity of ALS...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28678923/cardiac-amyloidosis-and-its-new-clinical-phenotype-heart-failure-with-preserved-ejection-fraction
#2
Evandro Tinoco Mesquita, Antonio José Lagoeiro Jorge, Celso Vale Souza, Thais Ribeiro de Andrade
Heart failure with preserved ejection fraction (HFpEF) is now an emerging cardiovascular epidemic, being identified as the main phenotype observed in clinical practice. It is more associated with female gender, advanced age and comorbidities such as hypertension, diabetes, obesity and chronic kidney disease. Amyloidosis is a clinical disorder characterized by the deposition of aggregates of insoluble fibrils originating from proteins that exhibit anomalous folding. Recently, pictures of senile amyloidosis have been described in patients with HFpEF, demonstrating the need for clinical cardiologists to investigate this etiology in suspect cases...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28672256/reduced-lateral-prefrontal-cortical-volume-is-associated-with-performance-on-the-modified-iowa-gambling-task-a-surface-based-morphometric-analysis-of-previously-deployed-veterans
#3
Nicholas D Fogleman, Farah Naaz, Lindsay K Knight, Teodora Stoica, Samantha C Patton, Jennifer H Olson-Madden, Meghan C Barnhart, Trisha A Hostetter, Jeri Forster, Lisa A Brenner, Marie T Banich, Brendan E Depue
Post-traumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are two of the most common consequences of combat deployment. Estimates of comorbidity of PTSD and mTBI are as high as 42% in combat exposed Operation Enduring Freedom, Operation Iraqi Freedom and Operation New Dawn (OEF/OIF/OND) Veterans. Combat deployed Veterans with PTSD and/or mTBI exhibit deficits in classic executive function (EF) tasks. Similarly, the extant neuroimaging literature consistently indicates abnormalities of the ventromedial prefrontal cortex (vmPFC) and amygdala/hippocampal complex in these individuals...
June 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28661934/associations-among-posttraumatic-stress-disorder-symptoms-substance-use-and-affective-attentional-processing-in-oef-oif-ond-veterans
#4
Gabrielle I Liverant, Melissa M Amick, Shimrit K Black, Michael Esterman, Blair E Wisco, Molly C Gibian, Brian P Marx, Regina E McGlinchey
The majority of research examining affective attentional bias in posttraumatic stress disorder (PTSD) has not examined the influence of co-occurring psychiatric disorders. This study examined the individual and interactive effects of PTSD symptoms and substance use disorders (SUDs) on affective attentional processing among 323 veterans deployed to Iraq or Afghanistan. Participants were divided into those with SUD (SUD+, n = 46) and those without (SUD-, n = 277). Substance use disorder was determined using the Structured Clinical Interview for DSM-IV...
June 28, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28658364/prevalence-and-factors-associated-with-human-brucellosis-in-livestock-professionals
#5
Franco Cazembe Mufinda, Fernando Boinas, Carla Nunes
OBJECTIVE: The objective of this study is to estimate the seroprevalence of human brucellosis in livestock professionals and analyze the factors associated with brucellosis focusing on sociodemographic variables and the variables of knowledge and practices related to the characteristics of the activities carried out in livestock. METHODS: This is a cross-sectional seroepidemiological study with a population of 131 workers of butchers, slaughter rooms, and slaughterhouse and 192 breeders sampled randomly in Namibe province, Angola...
June 22, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28636398/ultrafast-carrier-trapping-in-thick-shell-colloidal-quantum-dots
#6
Ankit Jain, Oleksandr Voznyy, Marek Korkusinski, Pawel Hawrylak, Edward H Sargent
It has previously been found that Auger processes can lead to femtosecond carrier trapping in quantum dots, limiting their performance in optoelectronic applications that rely on radiative recombination. Using atomistic simulations, we investigate whether a shell can protect carriers from Auger-assisted trapping. For these studies we investigate CdSe/CdS core-shell quantum dots having total diameters reaching up to 10 nm. We find trapping lifetimes as fast as 1 ps for 2 nm shells, and we report that shells as thick as 6 nm are required to suppress trapping fully...
June 28, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28632031/mr-imaging-of-the-anterior-visual-pathway-in-primary-open-angle-glaucoma-correlation-with-octopus-101-perimetry-and-spectralis-optical-coherence-tomography-findings
#7
Mehmet Giray Ersoz, Yeliz Pekcevik, Emre Ayintap, İrfan Botan Gunes, Duygu Kunak Mart, Ersin Yucel, Gamze Türe
PURPOSE: To investigate structural changes in the visual pathway measured by magnetic resonance imaging (MRI) and its relationship with the clinical severity of glaucoma in primary open-angle glaucoma (POAG) patients. MATERIALS AND METHODS: The study included 28 patients with POAG and 26 age- and sex-matched healthy volunteers. All the subjects underwent spectral domain optical coherence tomography (OCT) of the peripapillary retina nerve fiber layer (RNFL). The optic nerve diameter (OND), chiasma height (Ch), and lateral geniculate nucleus height (LGNh) were measured bilaterally using a 1...
February 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28616896/high-resolution-transbulbar-ultrasonography-helping-differentiate-intracranial-hypertension-in-bilateral-optic-disc-oedema-patients
#8
Qian Chen, Weimin Chen, Min Wang, Xinghuai Sun, Yan Sha, Zhenxin Li, Guohong Tian
PURPOSE: The enlargement of optic nerve sheath diameter (ONSD) has been proven to be related with raised intracranial pressure (ICP). No prospective study has been focused on utilizing retrobulbar ultrasonography in optic disc oedema patient presented to ophthalmologist. METHODS: High-resolution transbulbar ultrasonography was performed in a cohort of patient presented with bilateral optic disc oedema. The subarachnoid space of optic nerve (SAS), ONSD and optic nerve diameter (OND) was measured prior to other ancillaries including lumbar puncture...
June 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28595276/premorbid-iq-predicts-postconcussive-symptoms-in-oef-oif-ond-veterans-with-mtbi
#9
Jada J Stewart-Willis, Daniel Heyanka, Zoe Proctor-Weber, Heather England, Maya Bruhns
Objective: Extant literature has demonstrated that symptoms of postconcussive syndrome (PCS) persist well beyond the expected 3-month post-injury recovery period in a minority of individuals with mild traumatic brain injury (mTBI). Suboptimal performance on validity measures and pre- and post-injury psychosocial stressors - rather than actual mTBI or current cognitive functioning - have been identified as predictors of chronic PCS. Whether premorbid IQ has any influence on chronic PCS has been understudied, in the context of established psychogenic etiologies...
June 8, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28578182/a-confirmatory-factor-analysis-of-the-ptsd-checklist-5-in-veteran-and-college-student-samples
#10
Jasmine R Eddinger, Meghan E McDevitt-Murphy
An important change in the conceptualization of posttraumatic stress disorder (PTSD) has been the shift from a three-factor model used in the DSM-IV-TR to the current four-factor model used in DSM-5. Early research initially supported the three-factor model, but most recent data suggest a four-factor model provides the best fit. Still other research has examined evidence for a five-factor model that would include depression sequelae. By way of a confirmatory factor analysis, we demonstrate the reliability of DSM-5 PTSD criteria clustering in a sample of 124 OEF/OIF/OND Veterans treated at a VAMC (49% white, 89% men) and a sample of 737 college students (48% white, 78% women)...
May 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28578025/multimarker-risk-stratification-approach-at-multiple-sclerosis-onset
#11
Lidia Fernández-Paredes, Armanda Casrouge, Jérémie Decalf, Clara de Andrés, Luisa Maria Villar, Rebeca Pérez de Diego, Bárbara Alonso, José Carlos Álvarez Cermeño, Rafael Arroyo, Marta Tejera-Alhambra, Joaquín Navarro, Celia Oreja-Guevara, Margarita López Trascasa, Ansgar Seyfferth, Maria Angel García Martínez, Roberto Álvarez Lafuente, Matthew L Albert, Silvia Sánchez-Ramón
Delay in the diagnosis of multiple sclerosis (MS) stems from the lack of specific clinical and analytical markers to assist in the early diagnosis and prediction of progressive course. We propose a decision-tree model that better defines early at onset MS patients and those with the progressive form by analysing a 12-biomarkers panel in serum and CSF samples of patients with MS, other neurological diseases (OND) and healthy contols. Thus, patients at onset of neurological disease were first classified by serum IL-7 levels <141pg/ml (OR=6...
May 31, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28545005/the-efficacy-of-trauma-management-therapy-a-controlled-pilot-investigation-of-a-three-week-intensive-outpatient-program-for-combat-related-ptsd
#12
Deborah C Beidel, B Christopher Frueh, Sandra M Neer, Carl W Lejuez
Despite the 8-18.5% of returning Operation Iraqi Freedom (OIF), Operation Enduring Freedom (OEF) and Operation New Dawn (OND) veterans who are suffering from posttraumatic stress disorder (PTSD), few receive empirically supported treatments. Among those that do, the dropout rate is high and more than 50% retain their diagnosis after treatment. This study evaluated the efficacy of Trauma Management Therapy (TMT), delivered in a 3-week intensive outpatient (IOP) format. TMT combines virtual-reality augmented individual exposure therapy with a group intervention to address social isolation, anger, and depression...
May 11, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28517950/gender-differences-in-service-utilization-among-operations-enduring-freedom-iraqi-freedom-and-new-dawn-veterans-affairs-patients-with-severe-mental-illness-and-substance-use-disorders
#13
Janelle M Painter, Emily Brignone, Amanda K Gilmore, Keren Lehavot, Jamison Fargo, Ying Suo, Tracy Simpson, Marjorie E Carter, Rebecca K Blais, Adi V Gundlapalli
Severe mental illness (SMI) and substance use disorders (SUD) are among the more chronic and costly mental health conditions treated in the Department of Veterans Affairs (VA). Service use patterns of returning veterans with SMI and SUD have received little attention. We examined gender differences in the utilization of VA services among a national sample of Operations Enduring Freedom, Iraqi Freedom, and New Dawn (OEF/OIF/OND) VA patients with SMI, SUD, and their comorbidity (SMI/SUD) in their first year of established VA care (N = 24,166)...
May 18, 2017: Psychological Services
https://www.readbyqxmd.com/read/28508653/synthesis-and-reactivity-of-5-substituted-furfuryl-carbamates-via-oxanorbornadienes
#14
Srinivas Tekkam, M G Finn
Furfuryl carbamates are labile and require care to be accessed by activating furfuryl alcohols. An alternative oxanorbornadiene (OND)-based strategy is presented for the preparation of 5-R-substituted furfuryl carbamates via the reactions of amines with intermediate OND carbonates. The resulting OND carbamates, which are stable for several months, undergo thiol mediated retro-Diels-Alder reaction to deliver the desired furfuryl carbamates in a single flask. Conditions for the selective hydrolysis of furfuryl carbamates in the presence of tert-butyloxycarbonyl (Boc) groups were identified, and it was shown that furfuryl carbamates can be used as a prodrug handle...
May 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/28505233/addition-of-droperidol-to-prophylactic-ondansetron-and-dexamethasone-in-children-at-high-risk-for-postoperative-vomiting-a-randomized-controlled-double-blind-study
#15
N Bourdaud, C François, O Jacqmarcq, M-L Guye, J Jean, C Studer, C Engrand-Donal, J-M Devys, F Boutin, E Guyot, N Bouazza, J-M Treluyer, G A Orliaguet
Background: : The combination of dexamethasone (DEX), ondansetron (OND) and droperidol (DRO) is efficacious in preventing postoperative nausea and vomiting in adults, but has not been well assessed in children. Methods: : Children undergoing elective surgery under general anaesthesia and considered at high risk for postoperative vomiting (POV) were randomly assigned to receive a combination of DEX, OND and placebo (Group A) or a combination of DEX, OND and DRO (Group B)...
June 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28489416/concordance-validity-of-pvts-in-a-sample-of-veterans-referred-for-mild-tbi
#16
Adam Zimmer, Daniel Heyanka, Zoe Proctor-Weber
Concordance validity of commonly used performance validity tests (PVTs) was assessed in a sample of Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) veterans referred to an mTBI screening clinic in a south-eastern Veterans Affairs hospital. Veteran service members (total n = 184) completed the Rey-15, Repeatable Battery of the Assessment for Neuropsychological Status Effort Index (RBANS EI), and Reliable Digit Span (RDS) from the Wechsler Intelligence Scales. Kappa coefficients and percentage of agreement were established to determine the level of concordance between the three measures...
May 10, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28483653/mental-health-does-not-moderate-compensatory-cognitive-training-efficacy-for-veterans-with-a-history-of-mild-traumatic-brain-injury
#17
Kathleen F Pagulayan, Maya O'Neil, Rhonda M Williams, Aaron P Turner, Shahrokh Golshan, Mai S Roost, Benjamin Laman-Maharg, Marilyn Huckans, Daniel Storzbach, Elizabeth W Twamley
OBJECTIVE: To examine the potential moderating effects of mental health symptoms on the efficacy of Compensatory Cognitive Training (CCT) for Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF)/Operation New Dawn (OND) Veterans with a history of mild traumatic brain injury (mTBI). DESIGN: Secondary analysis of a randomized controlled trial of CCT. Posttraumatic stress disorder (PTSD), depression, and substance dependence symptom severity were examined as potential moderators of CCT efficacy for subjective cognitive complaints, use of cognitive strategies, and objective neurocognitive performance...
May 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28453779/first-record-of-lutzomyia-lutzomyia-longipalpis-diptera-psychodidae-phlebotominae-on-the-trinational-frontier-brazil-peru-bolivia-of-south-western-amazonia
#18
Diones Antonio Borges, Silvia Maria Guerra Molina, Mara Cristina Pinto, Eunice Aparecida Bianchi Galati, Manuel Cesario, Dennys Ghenry Samillan Ortiz
Na América do Sul, a principal espécie de flebotomíneo envolvido na transmissão de Leishmania infantum chagasi , agente etiológico da Leishmaniose visceral (VL), é Lutzomyia longipalpis (Lutz & Neiva, 1912). Esta espécie já foi registrada na Colômbia, Venezuela, Bolívia, Argentina, Paraguai, Uruguai e Brasil, onde foram registradas em 24 dos 27 estados brasileiros, com exceção do Acre, Amazonas e Santa Catarina. As coletas foram realizadas por um ano (abril de 2013 a março de 2014) utilizando-se armadilhas de luz tipo de CDC em diferentes ambientes no município de Assis Brasil, estado do Acre...
April 25, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28446032/effect-of-intravesical-liposome-based-nerve-growth-factor-antisense-therapy-on-bladder-overactivity-and-nociception-in-a-rat-model-of-cystitis-induced-by-hydrogen-peroxide
#19
Tsuyoshi Majima, Pradeep Tyagi, Koji Dogishi, Mahendra Kashyap, Yasuhito Funahashi, Momokazu Gotoh, Michael B Chancellor, Naoki Yoshimura
The aim of this study was to evaluate whether liposome-based local suppression of nerve growth factor (NGF) in the bladder has effects on bladder hypersensitivity in a rat cystitis model induced by intravesical instillation of hydrogen peroxide (HP). HP (1.5%) was intravesically administered to adult female Sprague-Dawley rats. Liposomes complexed with NGF antisense oligonucleotide (OND) labeled with TYE563 fluorescent tag were intravesically instilled on day 2. Red fluorescence from the TYE 563 tag was observed with fluorescent microscopy on day 3...
July 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28438253/development-and-validation-of-the-work-conflict-appraisal-scale-wcas
#20
Pilar González-Navarro, Lucía Llinares-Insa, Rosario Zurriaga-Llorens, Susana Lloret-Segura
BACKGROUND: In the context of cognitive appraisal, the Work Conflict Appraisal Scale (WCAS) was developed to assess work conflict in terms of threat and challenge. METHOD: In the first study, the factorial structure of the scale was tested using confirmatory factor analysis with a Spanish multi-occupational employee sample (N= 296). In the sec-ond study, we used multi-sampling confirmatory factor analysis (N= 815) to cross-validate the results. RESULTS: The analyses confirm the validity of the scale and are con-sistent with the tri-dimensional conflict classification...
May 2017: Psicothema
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