Federico Massa, Caterina Martinuzzo, Nerea Gómez de San José, Virginia Pelagotti, Wendy Kreshpa, Samir Abu-Rumeileh, Lorenzo Barba, Pietro Mattioli, Beatrice Orso, Andrea Brugnolo, Nicola Girtler, Tiziana Vigo, Dario Arnaldi, Carlo Serrati, Antonio Uccelli, Silvia Morbelli, Andrea Chincarini, Markus Otto, Matteo Pardini
BACKGROUND: Neuronal pentraxin-2 (NPTX2), crucial for synaptic functioning, declines in cerebrospinal fluid (CSF) as cognition deteriorates. The variations of CSF NPTX2 across mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and its association with brain metabolism remain elusive, albeit relevant for patient stratification and pathophysiological insights. METHODS: We retrospectively analyzed 49 MCI-AD patients grouped by time until dementia (EMCI, n = 34 progressing within 2 years; LMCI, n = 15 progressing later/stable at follow-up)...
December 29, 2023: Journal of Neurology