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https://www.readbyqxmd.com/read/29767522/traceless-release-of-alcohols-using-thiol-sensitive-oxanorbornadiene-linkers
#1
Allison G Aioub, Cody J Higginson, M G Finn
A class of ester-amide oxanorbornadiene (EA-OND) molecules was developed to release alcohol cargos by succinimide formation upon addition of a thiol reagent. The resulting ring-closed adducts undergo further fragmentation by retro-Diels-Alder reaction to release a furan moiety in a manner similar to oxanorbornadiene diesters. The rates of each of these fragmentation pathways in the same medium were found to be sensitive to the steric nature of the amide substituent. Alcohol release was much faster in protic solvents than in aprotic ones, suggesting that this system may be useful for rapid response to thiols in biological environments...
May 16, 2018: Organic Letters
https://www.readbyqxmd.com/read/29759192/the-polystyrene-divinylbenzene-stationary-phase-hybridized-with-oxidized-nanodiamonds-for-liquid-chromatography
#2
Zhongping Huang, Peng Yao, Qiulian Zhu, Lili Wang, Yan Zhu
A novel polystyrene-divinylbenzene microspheres hybridized with oxidized nanodiamonds (PS-DVB-OND) was synthesized by the method of seed swelling and polymerization. The oxidized nanodiamonds (OND) were characterized by Fourier transform infrared (FTIR) spectra, X-ray phtoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), X-ray diffraction (XRD). PS-DVB-OND particles were characterized by scanning electron microscopy (SEM) and transmission electron microscope (TEM). The result suggested that OND were successfully embedded into the polymer microspheres with the diameter of 6 ± 2 µm...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29743290/cerebrospinal-fluid-immunoglobulin-light-chain-ratios-predict-disease-progression-in-multiple-sclerosis
#3
Emma Rathbone, Lindsay Durant, James Kinsella, Antony R Parker, Ghaniah Hassan-Smith, Michael R Douglas, S John Curnow
OBJECTIVE: To determine whether the ratio of cerebrospinal fluid (CSF) immunoglobulin kappa to lambda light chains at time of multiple sclerosis (MS) diagnosis predicts disease progression and whether this was intrinsic to CSF plasmablasts. METHODS: CSF and peripheral blood were obtained from patients undergoing elective diagnostic lumbar puncture and included clinically isolated syndrome (CIS) (n=43), relapsing remitting MS (RRMS; n=50), primary progressive MS (PPMS; n=20) and other neurological disease controls, both inflammatory (ONID; n=23) and non-inflammatory (OND; n=114)...
May 9, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29723022/a-supported-education-service-pilot-for-returning-veterans-with-posttraumatic-stress-disorder
#4
Marsha Langer Ellison, Erin D Reilly, Lisa Mueller, Mark R Schultz, Charles E Drebing
A randomized controlled pilot of supported education services was conducted with 33 Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn (OEF, OIF, OND, respectively) veterans with posttraumatic stress disorder (PTSD) who had higher education goals. Veteran peers delivered supported education services to an intervention group; for the control group, peers provided "matched attention" of generalized support without supporting educational goals. The intervention was based on a manualized veteran-centric program of supported education using principles of supported employment for individuals living with mental illness and components of civilian models of supported education...
May 2018: Psychological Services
https://www.readbyqxmd.com/read/29723019/actuarial-prediction-of-psychotherapy-retention-among-iraq-afghanistan-veterans-with-posttraumatic-stress-disorder
#5
Cj Eubanks Fleming, Tatyana Kholodkov, Kirsten H Dillon, Benita Belvet, Eric F Crawford
The present study aimed to identify predictors of treatment retention in a sample of Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) veterans with posttraumatic stress disorder (PTSD) who were referred for PTSD-focused treatment through completion of a Veterans Affairs (VA) specialty clinic introductory information session. A total of 124 returning veterans (89% male, 53% Caucasian, 40% African American, 2% Latino; average age = 37 years) participated in an introductory session intended to facilitate informed decision making about treatment selection for PTSD...
May 2018: Psychological Services
https://www.readbyqxmd.com/read/29705230/risk-factor-analysis-for-the-outcomes-of-indirect-traumatic-optic-neuropathy-with-no-light-perception-at-initial-visual-acuity-testing
#6
I-Li Lai, Han-Tsung Liao
BACKGROUND: The optimal management of indirect traumatic optic neuropathy (TON) is controversial. We aimed to compare the differences in visual improvement by treatment option in patients presenting with TON and no light perception (NLP). We also wanted to identify any patient-related factors that might favor the use of SPT or OND. MATERIAL AND METHODS: We retrospectively identified 46 consecutive patients with indirect TON treated at Chang Gung Memorial Hospital between 2007 and 2015...
April 26, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29704581/individual-differences-in-combat-experiences-and-error-related-brain-activity-in-oef-oif-ond-veterans
#7
Narmeen I Khan, Katie L Burkhouse, Lynne Lieberman, Stephanie M Gorka, Julia A DiGangi, Christopher Schroth, Alyssa Frederick, Amy E Kennedy, Darrin M Aase, Justin E Greenstein, Eric Proescher, Greg Hajcak, K Luan Phan
Increased error-related negativity (ERN) has been implicated in the pathophysiology of multiple forms of psychopathology. Although there is increasing evidence that the ERN can be shaped by environment and experience, no studies to date have examined this question in a clinical sample. In the current study, we examined the influence of combat exposure on the ERN using electroencephalogram (EEG) in a sample of military veterans with a high prevalence of psychopathology. Participants included sixty-seven U.S...
April 25, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29624539/tinnitus-depression-anxiety-and-suicide-in-recent-veterans-a-retrospective-analysis
#8
Erin Martz, Chennettée Jelleberg, Deborah D Dougherty, Charles Wolters, Aaron Schneiderman
OBJECTIVES: The purpose of this project was to investigate whether there is an association between tinnitus diagnosis and suicide and whether depression and anxiety strengthen that association. Given that tinnitus is the top service-connected disability among U.S. Veterans (Veterans Benefits Administration, 2016) and that suicide among Veterans has been occurring at a higher frequency as compared with community suicide rates (Hoffmire et al., 2015), the possible associations between tinnitus and suicide will be explored...
April 5, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29554536/postconcussive-symptoms-pcs-following-combat-related-traumatic-brain-injury-tbi-in-veterans-with-posttraumatic-stress-disorder-ptsd-influence-of-tbi-ptsd-and-depression-on-symptoms-measured-by-the-neurobehavioral-symptom-inventory-nsi
#9
Katherine E Porter, Murray B Stein, Brian Martis, Kimberly M Avallone, Lauren B McSweeney, Erin R Smith, Naomi M Simon, Sean Gargan, Israel Liberzon, Charles W Hoge, Sheila A M Rauch
Mild traumatic brain injury (mTBI) is commonly reported in recent combat Veterans. While the majority resolve, some Veterans develop postconcussive symptoms (PCS). Previous research suggests these symptoms are not specific to head injury and are often associated with psychiatric symptoms. The current study examines the relative contributions of posttraumatic stress, depressive symptoms, and TBI on postconcussive symptoms, and explores whether the relationship remains after controlling for symptom overlap. Two hundred eighteen combat Veterans from Operation Iraqi Freedom (OIF), Operation Enduring Freedom (OEF), and Operation New Dawn (OND) provided the data for this study as part of a baseline evaluation for inclusion into larger treatment study for posttraumatic stress disorder (PTSD)...
March 10, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29545974/opioid-use-initiation-progression-and-motivations-among-oef-oif-ond-era-veterans-in-new-york-city-an-age-period-cohort-analysis
#10
Luther Elliott, Andrew Golub, Alexander Bennett
This study examines the temporal relationship between prescription opioid (PO) and heroin use among veterans in New York City. Drawing on survey data from a convenience sample of 214 Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND)-era opioid-using military veterans, analyses demonstrate substantial cohort-level variation. Most notably, heroin use prior to PO initiation and prior to military enlistment was reported more frequently among the cohorts born prior to 1970 and after 1984...
2018: Military Behavioral Health
https://www.readbyqxmd.com/read/29514350/depression-in-female-veterans-returning-from-deployment-the-role-of-social-factors
#11
Holly Sairsingh, Phyllis Solomon, Amy Helstrom, Dan Treglia
Objective: Women are serving in the armed forces and deployed to areas of conflict in increasing numbers. Problems such as depressive symptoms and risks related to combat exposure can have negative effects on adjustment following service; understanding the relationship between these problems may contribute to strategies providers can use to facilitate healthy adjustment after deployment. The purpose of this study is to examine social factors as they relate to mental health adjustment, namely depressive symptoms among female veterans who served in Iraq and Afghanistan as part of Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn (OND)...
March 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29514348/causes-of-oral-maxillofacial-injury-of-u-s-military-personnel-in-iraq-and-afghanistan-2001-2014
#12
Timothy A Mitchener, Noel E Dickens, John W Simecek
Background: Few studies have examined the causes or mechanisms of oral-maxillofacial (OMF) injury among deployed military populations. This study reports causes of OMF injuries to U.S. Department of Defense personnel deployed to Afghanistan in Operation Enduring Freedom (OEF) or to Iraq in Operation Iraqi Freedom (OIF) and Operation New Dawn (OND). This study provides follow-on analysis of a previous report of OMF injury rates among U.S. military personnel in Iraq and Afghanistan from 2001 to 2014...
March 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29497395/consequences-of-disregarding-metric-invariance-on-diagnosis-and-prognosis-using-psychological-tests
#13
David Blanco-Canitrot, Jesús M Alvarado, Daniel Ondé
No abstract text is available yet for this article.
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29486403/trauma-related-guilt-cognitions-partially-mediate-the-relationship-between-ptsd-symptom-severity-and-functioning-among-returning-combat-veterans
#14
S B Norman, M Haller, Hyungjin Myra Kim, C B Allard, K E Porter, M B Stein, M R Venners, C C Authier, S A M Rauch
Trauma related guilt, a distressing emotion associated with negative cognitions regarding one's actions or inaction during a traumatic event, is common among individuals with posttraumatic stress disorder (PTSD). We hypothesized that trauma related guilt cognitions would partially explain the relationship between PTSD symptom severity and functioning. The sample consisted of 254 combat veterans or active duty military personnel who served in Operation Enduring Freedom, Operation Iraqi Freedom or Operation New Dawn (OEF/OIF/OND) who consented to participate in a larger PTSD treatment study...
May 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29434217/il-23-and-il-27-levels-in-serum-are-associated-with-the-process-and-the-recovery-of-guillain-barr%C3%A3-syndrome
#15
Jing Peng, Hui Zhang, Peidong Liu, Min Chen, Bing Xue, Rui Wang, Jifei Shou, Juanfeng Qian, Zhikang Zhao, Yanmeng Xing, Hongbo Liu
IL-23 and IL-27 are believed to be involved in the pathogenesis of Guillain-Barré syndrome (GBS). However, changes in these cytokines during the dynamic pathological and recovery processes of GBS are not well described. In the present study, plasma was collected from 83 patients with various stages of GBS, 70 patients with central nervous system demyelinating diseases,70 patients with other neurological diseases (OND) and 70 age- and sex-matched healthy volunteers. Serum levels of IL-23, IL-27, and Campylobacter jejuni (CJ) IgM were assessed using enzyme linked immunosorbent assay (ELISA)...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29414124/a-novel-unit-dose-approach-for-the-pharmaceutical-compounding-of-an-orodispersible-film
#16
Wen Chin Foo, Yuet Mei Khong, Rajeev Gokhale, Sui Yung Chan
Orodispersible films (ODF) have clinical potential as extemporaneous pharmacy preparations for individualized pharmacotherapy. However, the conventional method of ODF preparation using a film applicator may limit its application, due to content uniformity challenges arising from viscosity changes of the casting solution and varied operator manipulation. This study proposes the unit-dose (UD) plate as an alternative to the film applicator for compounding individual ODFs. Using a design-of-experiments approach, we developed an extemporaneous ODF formulation for an antiemetic drug, ondansetron hydrochloride dihydrate (OND), at a clinically relevant dose...
March 25, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29407725/heart-rate-reactivity-to-trauma-related-imagery-as-a-measure-of-ptsd-symptom-severity-examining-a-new-cohort-of-veterans
#17
Paula L Castro-Chapman, Scott P Orr, John Berg, Suzanne L Pineles, Jessica Yanson, Kristen Salomon
For over three decades, there has been considerable research documenting increased physiological reactivity to trauma-related stimuli as a characteristic feature of posttraumatic stress disorder (PTSD). The present study explored the potential for physiological assessment to aid in defining and validating screening criteria for the presence of significant PTSD-related symptoms in a sample of OEF/OIF/OND Veterans seeking care in a VA post-deployment health clinic. Heart rate reactivity scores during the imagining phase of the script-driven imagery paradigm were compared across groups of individuals with and without probable PTSD diagnoses, as defined by PCL-IV cutoff scores ranging from 40 to 60...
March 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29373501/impact-blast-traumatic-brain-injury-implications-for-therapy
#18
REVIEW
Satoshi Yamamoto, Douglas S DeWitt, Donald S Prough
Traumatic brain injury (TBI) is one of the most frequent causes of combat casualties in Operations Iraqi Freedom (OIF), Enduring Freedom (OEF), and New Dawn (OND). Although less common than combat-related blast exposure, there have been significant numbers of blast injuries in civilian populations in the United States. Current United States Department of Defense (DoD) ICD-9 derived diagnoses of TBI in the DoD Health Care System show that, for 2016, severe and moderate TBIs accounted for just 0.7% and 12.9%, respectively, of the total of 13,634 brain injuries, while mild TBIs (mTBIs) accounted for 86% of the total...
January 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29370869/a-new-enzyme-linked-immunosorbent-assay-for-neurofilament-light-in-cerebrospinal-fluid-analytical-validation-and-clinical-evaluation
#19
Lorenzo Gaetani, Kina Höglund, Lucilla Parnetti, Fani Pujol-Calderon, Bruno Becker, Paolo Eusebi, Paola Sarchielli, Paolo Calabresi, Massimiliano Di Filippo, Henrik Zetterberg, Kaj Blennow
BACKGROUND: Cerebrospinal fluid (CSF) neurofilament light (NfL) is a reliable marker of neuro-axonal damage in different neurological disorders that is related to disease severity. To date, all recent studies performed in human CSF have used the same enzyme-linked immunosorbent assay (ELISA). To confirm the large body of evidence for NfL, we developed a new ELISA method and here we present the performance characteristics of this new ELISA for CSF NfL in different neurological disorders...
January 23, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29362020/verbal-memory-deficits-in-oef-oif-ond-veterans-exposed-to-blasts-at-close-range
#20
Laura J Grande, Meghan E Robinson, Lauren J Radigan, Laura K Levin, Catherine B Fortier, William P Milberg, Regina E McGlinchey
OBJECTIVES: This study investigated the relationship between close proximity to detonated blast munitions and cognitive functioning in OEF/OIF/OND Veterans. METHODS: A total of 333 participants completed a comprehensive evaluation that included assessment of neuropsychological functions, psychiatric diagnoses and history of military and non-military brain injury. Participants were assigned to a Close-Range Blast Exposure (CBE) or Non-Close-Range Blast Exposure (nonCBE) group based on whether they had reported being exposed to at least one blast within 10 meters...
May 2018: Journal of the International Neuropsychological Society: JINS
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