Helena Bui, Amena Keshawarz, Mengyao Wang, Mikyeong Lee, Scott M Ratliff, Lisha Lin, Kira S Birditt, Jessica D Faul, Annette Peters, Christian Gieger, Thomas Delerue, Sharon L R Kardia, Wei Zhao, Xiuqing Guo, Jie Yao, Jerome I Rotter, Yi Li, Xue Liu, Dan Liu, Juliana F Tavares, Gökhan Pehlivan, Monique M B Breteler, Irma Karabegovic, Carolina Ochoa-Rosales, Trudy Voortman, Mohsen Ghanbari, Joyce B J van Meurs, Mohamed Kamal Nasr, Marcus Dörr, Hans J Grabe, Stephanie J London, Alexander Teumer, Melanie Waldenberger, David R Weir, Jennifer A Smith, Daniel Levy, Jiantao Ma, Chunyu Liu
Background Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. Results We generated an alcohol consumption epigenetic risk score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. We found an association of alcohol intake with the ERS in the meta-analysis with 0...
April 19, 2024: Research Square