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https://www.readbyqxmd.com/read/28991127/safe-use-of-low-molecular-weight-heparin-in-pediatric-acute-lymphoblastic-leukemia-and-lymphoma-around-lumbar-punctures
#1
Jeremie H Estepp, Matthew P Smeltzer, Guolian Kang, Scott C Howard, Ulrike M Reiss
Children with acute lymphoblastic leukemia or lymphoma (ALL) undergo multiple lumbar punctures (LPs) and frequently require low-molecular-weight heparin (LMWH) for thromboembolic complications. We evaluated if withholding LMWH 24 hours before and after LPs prevented bleeding complications. Children (n=133) with ALL from who were: (1) treated at St. Jude Children's Research Hospital, (2) received LMWH (2×/day of ~1 mg/kg) between January 2004 until December 2012, and (3) underwent a LP were analyzed. Spinal hematoma was defined as a clinical suspicion leading to diagnostic imaging...
October 4, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28988888/small-bowel-tumors-a-digestive-endoscopy-society-of-taiwan-dest-multicenter-enteroscopy-based-epidemiologic-study
#2
Chen-Shuan Chung, Chi-Ming Tai, Tien-Yu Huang, Chen-Wang Chang, Kuan-Chih Chen, Chao-Ming Tseng, Horng-Yuan Wang, Cheng-Hsin Chu, Jiann-Ming Wu, Yun Chen, Hsiu-Po Wang
BACKGROUND/PURPOSE: Small bowel (SB) accounts for the majority of gastrointestinal tract but its tumors are rare and always overlooked. In this study, we aimed to evaluate the epidemiology of SB tumors. METHODS: This multicenter retrospective study utilized endoscopy database from 2006/11 to 2016/07. Baseline demographic characteristics, clinical, radiologic and endoscopic findings were collected. RESULTS: Totally 103 (34 benign, 69 malignant lesions) patients with SB tumors in 1070 enteroscopic examinations were enrolled...
October 5, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28902958/nonregenerative-immune-mediated-anemia-associated-with-a-diffuse-large-b-cell-lymphoma-in-a-captive-jaguar-panthera-onca
#3
Monika A Keresztes, Manfred Henrich, Penelope Baloi, Sascha Gerst, Jens-Christian Rudnick, Judith Langenstein, Andreas Moritz, Natali Bauer
An 18-year-old male castrated jaguar (Panthera onca) was presented with anorexia and continuous bleeding from the oral cavity after a history of fighting with the partner animal. Clinical evaluation revealed ulcerating lesions on the gingiva and hard palate and a hematoma on the tongue. Computed tomography of the head and endoscopic examination of the esophagus and stomach were unremarkable. Hematology and clinical chemistry revealed severe nonregenerative anemia, mild thrombocytopenia, and moderate azotemia...
September 13, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28838088/management-and-outcomes-of-patients-with-atrial-fibrillation-and-a-history-of-cancer-the-orbit-af-registry
#4
Chiara Melloni, Peter Shrader, Joseph Carver, Jonathan P Piccini, Laine Thomas, Gregg C Fonarow, Jack Ansell, Bernard Gersh, Alan S Go, Elaine Hylek, Irving M Herling, Kenneth W Mahaffey, Anthony F Yu, Eric D Peterson, Peter R Kowey
Aims: The presence of cancer can complicate treatment choices for patients with atrial fibrillation (AF) increasing both the risk of thrombotic and bleeding events. Methods and results: Using data from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation, we aimed to characterize AF patients with cancer, to describe their management and to assess the association between cancer and cardiovascular (CV) outcomes. Among 9749 patients, 23.8% had history of cancer (57% solid malignancy, 1...
July 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28751558/characterization-of-atrial-fibrillation-adverse-events-reported-in-ibrutinib-randomized-controlled-registration-trials
#5
Jennifer R Brown, Javid Moslehi, Susan O'Brien, Paolo Ghia, Peter Hillmen, Florence Cymbalista, Tait D Shanafelt, Graeme Fraser, Simon Rule, Thomas J Kipps, Steven Coutre, Marie-Sarah Dilhuydy, Paula Cramer, Alessandra Tedeschi, Ulrich Jaeger, Martin Dreyling, John C Byrd, Angela Howes, Michael Todd, Jessica Vermeulen, Danelle F James, Fong Clow, Lori Styles, Rudy Valentino, Mark Wildgust, Michelle Mahler, Jan A Burger
The first-in-class Bruton's tyrosine kinase inhibitor ibrutinib has proven clinical benefit in B-cell malignancies; however, atrial fibrillation (AF) has been reported in 6-16% of ibrutinib patients. We pooled data from 1505 chronic lymphocytic leukemia and mantle cell lymphoma patients enrolled in four large, randomized, controlled studies to characterize AF with ibrutinib and its management. AF incidence was 6.5% [95% Confidence Interval (CI): 4.8, 8.5] for ibrutinib at 16.6-months versus 1.6% (95%CI: 0.8, 2...
October 2017: Haematologica
https://www.readbyqxmd.com/read/28730251/severe-upper-gastrointestinal-bleeding-determined-by-a-gastric-lymphoma-associated-with-helicobacter-pylori-positive-atrophic-gastritis
#6
Cosmin Vasile Obleagă, Cristin Constantin Vere, Ana Maria Pătraşcu, Emil Moraru, Antoanela Valentina Crafciuc, Maria Camelia Foarfă, Stelian ŞtefăniŢă Mogoantă, Costin Teodor Streba, Simona Bondari, Ştefan Paitici, Cecil Sorin Mirea, Ionică Daniel Vîlcea
The pathogenesis of gastric cancer regardless of histological structure is a classic example of gene-environment interaction, and an important epidemiological aspect was the recognized association with Helicobacter pylori infection. This paper describes a case of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in a young patient whose first sign of the disease was upper gastrointestinal bleeding and associated hemorrhagic shock. The patient is a 31-year-old man, diagnosed by endoscopy 10 years ago with H...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28710678/breast-magnetic-resonance-imaging-tips-for-the-diagnosis-of-silicone-induced-granuloma-of-a-breast-implant-capsule-sigbic
#7
REVIEW
Eduardo de Faria Castro Fleury, Ana Claudia Gianini, Veronica Ayres, Luciana C Ramalho, Rodrigo Oliveira Seleti, Decio Roveda
Complications resulting from the placement of silicone breast implants are becoming more frequent in our clinical practice. This is due to the increase in breast aesthetic surgeries at the beginning of the century, where breast augmentation using silicone implants was the main intervention performed. Generally, studies that discuss the complications of breast implants are restricted to reports of intra- or extra-capsular ruptures, contractures and haematomas. Currently, much importance has been given to anaplastic large cell lymphoma (ALCL) as a more severe complication related to silicone implants...
August 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28670081/treatment-of-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-presenting-simultaneously-with-acquired-hemophilia-and-warm-autoimmune-hemolytic-anemia
#8
Chelsea Williams, Christian Cable, Julia Choi
Since both acquired factor VIII inhibitor in non-hemophiliac patients and warm autoimmune hemolytic anemia are uncommon disorders with no case-controlled trials, managing these diseases can be challenging. We present a case of a 75-year-old man in whom both diseases were present simultaneously with life-threatening bleeding. This case is an example of the successful initial management and long-term treatment of acquired hemophilia A, warm autoimmune hemolytic anemia, and chronic lymphocytic leukemia/small lymphocytic lymphoma with rituximab, prednisone, and cyclophosphamide...
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28670078/b-lymphoblastic-lymphoma-of-the-rectum
#9
Puthillathu Unnikrishnan, Geetha Narayanan, Bhavya S Kumar, Nandini Devi
Lymphoblastic lymphoma is a neoplasm of immature cells committed to the B-cell or T-cell lineage. B-lymphoblastic lymphoma usually involves lymph nodes and extranodal sites, such as the skin, bone, and soft tissue. The rectum is a very rare site of involvement in B-lymphoblastic lymphoma. We describe a 26-year-old man who presented with bleeding per rectum and fecal incontinence. Endoscopy showed a large nodular friable lesion narrowing the entire rectal lumen. Biopsy was diagnostic of B-lymphoblastic lymphoma...
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28629235/atrial-fibrillation-as-a-complication-of-ibrutinib-therapy-clinical-features-and-challenges-of-management
#10
Bronwyn C Thorp, Xavier Badoux
Ibrutinib is a Bruton's tyrosine kinase (BTK) inhibitor finding increasingly widespread use in non-Hodgkin lymphoma. Evidence of an increased risk of atrial fibrillation (AF) emerged in Phase III studies with a median incidence of approximately 6%. The mechanism remains unknown, but inhibition of a cardioprotective pathway has been proposed. Ibrutinib induces a platelet function defect, increasing the bleeding risk of anticoagulation for AF stroke prophylaxis. Multiple potential drug interactions are an added complication...
June 20, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28609811/successful-management-of-unresectable-small-bowel-lymphoma-with-laparoscopy-assisted-surgical-exclusion-of-the-affected-intestine
#11
Tetsuya Kagawa, Tatsunori Kobayashi, Satoshi Ueyama, Hiroki Okabayashi, Tetsuya Ogino, Toshiyoshi Fujiwara
The incidence of small bowel lymphoma (SBL) is increasing worldwide. In contrast to resectable SBL, the treatment of unresectable SBL is still contentious. Here, we report a case of unresectable SBL that was treated by laparoscopic exclusion of the affected intestine before systemic chemotherapy was administered. An 84-year-old man was diagnosed with primary SBL involving extranodal dissemination. The patient received prophylactic surgery, namely exclusion of the affected intestine. This therapy diminishes well-known and life-threatening complications, such as perforation, bleeding, and obstruction, which may still occur after chemotherapy, and it makes the administration of chemotherapy safer...
June 13, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28558450/-transoral-coblation-assisted-endoscopic-minimally-invasive-surgery-for-superficial-tongue-base-tumours
#12
W Y Li, H Huo, D H Yang, J H Liu, J Wang, X F Jin, Y Y Niu
Objective: To introduce the method of transoral coblation-assisted endoscopic minimally invasive surgery for superficial tongue base tumour. Methods: A total of 15 patients treated with transoral coblation-assisted endoscopic minimally invasive surgery from Mar. 2006 to Aug. 2016 were retrospectively reviewed. There were 9 patients with malignant tumors, 6 patients with benign neoplasms. Adjuvant postoperative radiation therapy was applied in three cases of squamous cell carcinoma, neck was performed in four cases of cancer...
May 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28536906/current-status-of-bruton-s-tyrosine-kinase-inhibitor-development-and-use-in-b-cell-malignancies
#13
REVIEW
Andrew Aw, Jennifer R Brown
The B-cell receptor (BCR) pathway plays an important role in the survival, proliferation and trafficking of cancer cells in a variety of B-cell malignancies. Recently, a number of agents have been developed to target various components of the BCR pathway. One such target is Bruton's tyrosine kinase (BTK), a Tec family kinase member found near the cell membrane that is involved in upstream BCR signaling. The biological function of BTK in several B-cell lymphoid malignancies has led to the development of the oral BTK inhibitor ibrutinib...
July 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28489811/intravascular-large-b-cell-lymphoma-diagnosed-via-transjugular-liver-biopsy-in-a-patient-with-liver-dysfunction-and-thrombocytopenia-a-case-report
#14
Mi-Jung Kim, Ho-Sung Park, Ho-Young Yhim
RATIONALE: Intravascular large B-cell lymphoma (IVLBCL) is an extremely rare subtype of large B-cell lymphoma characterized by the presence of lymphoma cells within the lumen of small blood vessels. IVLBCL presents with nonspecific symptoms such as fever, weight loss, and bleeding. Because of its rarity and unremarkable clinical presentation, a timely diagnosis is very challenging. PATIENT CONCERNS: A 71-year-old Korean man complained of fever, but apart from pretibial pitting edema and mild thrombocytopenia, the physical examination and laboratory test findings were unremarkable...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489772/primary-diffuse-large-b-cell-lymphoma-of-the-uterine-cervix-successfully-treated-by-combined-chemotherapy-alone-a-case-report
#15
Ana María Cubo, Zandra Mileny Soto, Miguel Ángel Cruz, María José Doyague, Verónica Sancho, Aurymar Fraino, Óscar Blanco, Noemi Puig, Miguel Alcoceba, Marcos González, José María Sayagués
RATIONALE: Primary lymphomas of the uterine cervix are a rare disease. They are often misdiagnosed because of their rarity and because they can be easily confused with a squamous cell carcinoma of the cervix, as they are usually presented as exophytic mass with vaginal bleeding as their most common symptoms. Nevertheless, considering that both the prognosis and the treatment are completely different between them, differential diagnosis should be taken into account. PATIENT CONCERNS: A case of a 51-year-old woman with a primary diffuse large B-cell lymphoma of the cervix is presented...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28474649/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-diagnosing-mediastinal-lymphadenopathy
#16
Tanushree Gahlot, Ujjwal Parakh, Kusum Verma, Bobby Bhalotra, Neeraj Jain
CONTEXT: The diagnosis of mediastinal lymphadenopathy is always a challenge. There always a need of a technique that is highly accurate as well as safe for diagnosis the same. AIMS: The aim of the study is to assess the clinical usefulness and safety profile of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in diagnosing the patients with mediastinal lymphadenopathy. SETTINGS AND DESIGN: This was an observational prospective study...
May 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28470353/synchronous-diffuse-large-b-cell-lymphomas-of-the-endometrium-and-breast-a-staging-dilemma
#17
REVIEW
J P Gleeson, G B Woods, G A Watson, J Ryan, E Doyle, F Quinn, J C O'Keane, J A McCaffrey
BACKGROUND: A 66 years old presented with abnormal postmenopausal vaginal bleeding and was diagnosed with an endometrial lymphoma (diffuse large B cell type, DLBCL). A left breast lesion was found on PET CT which was subsequently biopsy-proven as a separate stage IE DLBCL, but she had no lymph node, bone marrow or spleen involvement. AIMS: This study aimed to review the available literature and discuss the management and staging of synchronous extra-nodal DLBCL's...
May 3, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28379860/silicone-breast-implants-and-autoimmune-rheumatic-diseases-myth-or-reality
#18
Jan Willem Cohen Tervaert, Maartje J Colaris, René R van der Hulst
PURPOSE OF REVIEW: In the present review, recent findings regarding silicone breast implants (SBIs) complicated by rheumatic autoimmune diseases are described. RECENT FINDINGS: Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may 'bleed' and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as 50 years ago. Silicones are spread throughout the body and can be detected in tissues and the central nervous system...
July 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28326798/indwelling-pleural-catheters-for-patients-with-hematologic-malignancies-a-14-year-single-center-experience
#19
Saadia A Faiz, Priyanka Pathania, Juhee Song, Liang Li, Diwakar D Balachandran, David E Ost, Rodolfo C Morice, Vickie R Shannon, Lara Bashoura, Georgie A Eapen, Carlos A Jimenez
RATIONALE: Placement of an indwelling pleural catheter is an established modality for symptom relief and pleurodesis in the treatment of malignant pleural effusion. Concerns remain regarding possible infectious complications, risk of hemorrhage, and the rate of pleurodesis with the use of pleural catheters in the treatment of hematologic malignancies. OBJECTIVES: The goals of our study were: (1) to evaluate the safety and cumulative incidence of pleurodesis with indwelling pleural catheters for patients with hematologic malignancies, and (2) to evaluate overall survival of this cohort of patients with pleural effusions...
June 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28325194/multimodality-treatment-of-gastric-lymphoma
#20
REVIEW
Naruhiko Ikoma, Brian D Badgwell, Paul F Mansfield
Gastric lymphoma is rare, accounting for 3% of gastric neoplasms and 10% of lymphomas. Treatment should be stratified based on histologic type, stage, Helicobacter pylori infection, and t(11;18) translocation status. Surgery is no longer a mainstay for treatment and should be reserved for rare situations such as perforation, fistula formation, and severe bleeding. Multimodal treatment, including H pylori eradication, radiation therapy, chemotherapy, and immunotherapy, should be provided as appropriate and can result in excellent outcomes...
April 2017: Surgical Clinics of North America
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