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https://www.readbyqxmd.com/read/28549069/correction-intrinsic-noise-profoundly-alters-the-dynamics-and-steady-state-of-morphogen-controlled-bistable-genetic-switches
#1
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pcbi.1005154.].
May 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28549067/correction-visualizing-the-structure-of-rna-seq-expression-data-using-grade-of-membership-models
#2
Kushal K Dey, Chiaowen Joyce Hsiao, Matthew Stephens
[This corrects the article DOI: 10.1371/journal.pgen.1006599.].
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28548882/finding-conducting-and-nurturing-science-a-virologist-s-memoir
#3
Anna Marie Ann Skalka Skalka
My laboratory investigations have been driven by an abiding interest in understanding the consequences of genetic rearrangement in evolution and disease, and in using viruses to elucidate fundamental mechanisms in biology. Starting with bacteriophages and moving to the retroviruses, my use of the tools of genetics, molecular biology, biochemistry, and biophysics has spanned more than half a century-from the time when DNA structure was just discovered to the present day of big data and epigenetics. Both riding and contributing to the successive waves of technology, my laboratory has elucidated fundamental mechanisms in DNA replication, repair, and recombination...
May 26, 2017: Annual Review of Virology
https://www.readbyqxmd.com/read/28548881/constraints-drivers-and-implications-of-influenza-a-virus-reassortment
#4
Anice C Lowen
Influenza A viruses are constantly changing. This change accounts for seasonal epidemics, infrequent pandemics, and zoonotic outbreaks. A major mechanism underlying the genetic diversification of influenza A virus is reassortment of intact gene segments between coinfecting viruses. This exchange is possible because of the segmented nature of the viral genome. Here, I first consider the constraints and drivers acting on influenza A virus reassortment, including the likelihood of coinfection at the host and cellular levels, mixing and assembly of heterologous gene segments within coinfected cells, and the fitness associated with reassortant genotypes...
May 26, 2017: Annual Review of Virology
https://www.readbyqxmd.com/read/28548661/co-evolution-with-staphylococcus-aureus-leads-to-lipopolysaccharide-alterations-in-pseudomonas-aeruginosa
#5
Mikael Tognon, Thilo Köhler, Bartosz G Gdaniec, Youai Hao, Joseph S Lam, Marie Beaume, Alexandre Luscher, Angus Buckling, Christian van Delden
Detrimental and beneficial interactions between co-colonizing bacteria may influence the course of infections. In cystic fibrosis (CF) airways, Staphylococcus aureus prevails in childhood, whereas Pseudomonas aeruginosa progressively predominates thereafter. While a range of interactions has been identified, it is unclear if these represent specific adaptations or correlated responses to other aspects of the environment. Here, we investigate how P. aeruginosa adapts to S. aureus by evolving P. aeruginosa in the presence and absence of S...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28548660/transcriptomic-and-micrornaomic-profiling-reveals-multi-faceted-mechanisms-to-cope-with-phosphate-stress-in-a-dinoflagellate
#6
Xinguo Shi, Xin Lin, Ling Li, Meizhen Li, Brian Palenik, Senjie Lin
Although gene regulation can occur at both transcriptional and epigenetic (microRNA) levels, combined transcriptomic and microRNAomic responses to environmental stress are still largely unexplored for marine plankton. Here, we conducted transcriptome and microRNAome sequencing for Prorocentrum donghaiense to understand the molecular mechanisms by which this dinoflagellate copes with phosphorus (P) deficiency. Under P-depleted conditions, G1/S specific cyclin gene was markedly downregulated, consistent with growth inhibition, and genes related to dissolved organic phosphorus (DOP) hydrolysis, carbon fixation, nitrate assimilation, glycolysis, and cellular motility were upregulated...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28548659/metatranscriptomic-analysis-of-prokaryotic-communities-active-in-sulfur-and-arsenic-cycling-in-mono-lake-california-usa
#7
Christian F Edwardson, James T Hollibaugh
This study evaluates the transcriptionally active, dissimilatory sulfur- and arsenic-cycling components of the microbial community in alkaline, hypersaline Mono Lake, CA, USA. We sampled five depths spanning the redox gradient (10, 15, 18, 25 and 31 m) during maximum thermal stratification. We used custom databases to identify transcripts of genes encoding complex iron-sulfur molybdoenzyme (CISM) proteins, with a focus on arsenic (arrA, aioA and arxA) and sulfur cycling (dsrA, aprA and soxB), and assigned them to taxonomic bins...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28548658/distinctive-microbiomes-and-metabolites-linked-with-weight-loss-after-gastric-bypass-but-not-gastric-banding
#8
Zehra Esra Ilhan, John K DiBaise, Nancy G Isern, David W Hoyt, Andrew K Marcus, Dae-Wook Kang, Michael D Crowell, Bruce E Rittmann, Rosa Krajmalnik-Brown
Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB) are anatomically different bariatric operations. RYGB achieves greater weight loss compared with LAGB. Changes in the gut microbiome have been documented after RYGB, but not LAGB, and the microbial contribution to sustainable surgical weight loss warrants further evaluation. We hypothesized that RYGB imposes greater changes on the microbiota and its metabolism than LAGB, and that the altered microbiota may contribute to greater weight loss...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28548657/the-endobacterium-of-an-arbuscular-mycorrhizal-fungus-modulates-the-expression-of-its-toxin-antitoxin-systems-during-the-life-cycle-of-its-host
#9
Alessandra Salvioli di Fossalunga, Justine Lipuma, Francesco Venice, Laurence Dupont, Paola Bonfante
Arbuscular mycorrhizal fungi (AMF) are widespread root symbionts that perform important ecological services, such as improving plant nutrient and water acquisition. Some AMF from the Gigasporaceae family host a population of endobacteria, Candidatus Glomeribacter gigasporarum (Cagg). The analysis of the Cagg genome identified six putative toxin-antitoxin modules (TAs), consisting of pairs of stable toxins and unstable antitoxins that affect diverse physiological functions. Sequence analysis suggested that these TA modules were acquired by horizontal transfer...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28548477/the-100-most-cited-articles-focused-on-thyroid-research-a-bibliometric-analysis
#10
Eun S Kim, Dae Y Yoon, Ki-Won Oh, Won-Young Lee, Eun-Joo Yun, Young L Seo, Young-Soo Rho
BACKGROUND: The number of citations that an article has received reflects its impact on a particular research area. METHODS: We determined the 100 most-cited articles in thyroid research via the Institute for Scientific Information Web of Knowledge database, using the search term. The following parameters were used to analyze the characteristics of the 100 most-cited articles: publication year, journal (including subject category and impact factor), number of citations and annual citations, authors, department, institution, country, type of study, and topic...
May 26, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28548282/estimating-the-effect-of-immortal-time-bias-in-urologic-research-a-case-example-of-testosterone-replacement-therapy
#11
Christopher J D Wallis, Refik Saskin, Steven A Narod, Calvin Law, Girish S Kulkarni, Arun Seth, Robert K Nam
OBJECTIVE: To quantify the effect of immortal-time bias in an observational study examining the effect of cumulative testosterone exposure on mortality. SUBJECTS AND METHODS: We used a population-based matched cohort study of men aged 66 and older newly treated with testosterone replacement therapy and matched-controls from 2007-2012 in Ontario, Canada to quantify the effects of immortal-time bias. We used generalized estimating equations to determine the association between cumulative testosterone replacement therapy exposure and mortality...
May 26, 2017: BJU International
https://www.readbyqxmd.com/read/28548009/letter-to-editor-of-medico-legal-journal
#12
George E Fowler, Pirashanthie Vivekananda-Schmidt
No abstract text is available yet for this article.
January 1, 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/28547293/nonsurgical-facial-rejuvenation-outcomes-and-safety-of-neuromodulator-and-soft-tissue-filler-procedures-performed-in-a-resident-cosmetic-clinic
#13
Ali A Qureshi, Rajiv P Parikh, Ketan Sharma, Terence M Myckatyn, Marissa M Tenenbaum
BACKGROUND: The ability to perform nonsurgical facial rejuvenation procedures is a core competency requirement for plastic surgery residents. However, limited data exist on training models to achieve competency in nonsurgical facial rejuvenation and on outcomes of these procedures performed by residents. The purpose here is to evaluate patient-reported outcomes and safety of nonsurgical facial rejuvenation procedures performed by plastic surgery residents. METHODS: We prospectively enrolled 50 patients undergoing neuromodulator and/or soft-tissue filler injections in a resident cosmetic clinic between April and August 2016...
May 25, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28547272/conflict-of-interest-what-is-it-and-how-do-journals-manage-it-in-the-publication-process
#14
EDITORIAL
Steven Swift, Diaa Rizk, Gunnar Lose
No abstract text is available yet for this article.
May 25, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28547119/systematic-review-of-meditation-based-interventions-for-children-with-adhd
#15
REVIEW
Subhadra Evans, Mathew Ling, Briony Hill, Nicole Rinehart, David Austin, Emma Sciberras
Meditation-based interventions such as mindfulness and yoga are commonly practiced in the general community to improve mental and physical health. Parents, teachers and healthcare providers are also increasingly using such interventions with children. This review examines the use of meditation-based interventions in the treatment of children with Attention-Deficit Hyperactivity Disorder (ADHD). Electronic databases searched included PsycINFO, Medline, CINAHL, and AMED. Inclusion criteria involved children (aged to 18 years) diagnosed with ADHD, delivery of a meditation-based intervention to children and/or parents, and publication in a peer-reviewed journal...
May 25, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28546900/response-to-kruse-plass-et-al-2017-regarding-the-risk-to-non-target-lepidopteran-larvae-exposed-to-pollen-from-one-or-more-of-three-bt-maize-events-mon810-bt11-and-1507
#16
Joe N Perry, Paolo Barberi, Detlef Bartsch, A N E Birch, Achim Gathmann, Jozsef Kiss, Barbara Manachini, Marco Nuti, Stefan Rauschen, Joachim Schiemann, Mechthild Schuppener, Jeremy Sweet, Christoph C Tebbe, Fabio Veronesi
We respond to the paper of Kruse-Plass et al. (Environ Sci Eur 29:12, 2017), published in this journal, regarding the risk to non-target lepidopteran larvae exposed to pollen from one or more of three Bt maize events (MON810, Bt11 and 1507). We emphasise that what is important for environmental risk assessment is not the number of pollen grains per se, but the degree of exposure of a NT lepidopteran larva to Bt protein contained in maize pollen. The main text of this response deals with general issues which Kruse-Plass et al...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28546644/engaging-gatekeepers-optimizing-decision-making-and-mitigating-bias-design-specifications-for-systemic-diversity-interventions
#17
Claartje J Vinkenburg
In this contribution to the Journal of Applied Behavioral Science Special Issue on Understanding Diversity Dynamics in Systems: Social Equality as an Organization Change Issue, I develop and describe design specifications for systemic diversity interventions in upward mobility career systems, aimed at optimizing decision making through mitigating bias by engaging gatekeepers. These interventions address the paradox of meritocracy that underlies the surprising lack of diversity at the top of the career pyramid in these systems...
June 2017: Journal of Applied Behavioral Science
https://www.readbyqxmd.com/read/28546543/metabolic-profiling-of-polycystic-ovary-syndrome-reveals-interactions-with-abdominal-obesity
#18
Alexessander Couto Alves, Beatriz Valcarcel, Ville-Petteri Mäkinen, Laure Morin-Papunen, Sylvain Sebert, Antti J Kangas, Pasi Soininen, Shikta Das, Maria De Iorio, Lachlan Coin, Mika Ala-Korpela, Marjo-Riitta Järvelin, Stephen Franks
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance, and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels. DESIGN AND METHODS: We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3,127)...
May 26, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28546138/mental-health-mobile-apps-for-preadolescents-and-adolescents-a-systematic-review
#19
REVIEW
Rebecca Grist, Joanna Porter, Paul Stallard
BACKGROUND: There are an increasing number of mobile apps available for adolescents with mental health problems and an increasing interest in assimilating mobile health (mHealth) into mental health services. Despite the growing number of apps available, the evidence base for their efficacy is unclear. OBJECTIVE: This review aimed to systematically appraise the available research evidence on the efficacy and acceptability of mobile apps for mental health in children and adolescents younger than 18 years...
May 25, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28546069/this-month-in-ajp
#20
(no author information available yet)
The following highlights summarize research articles that are published in the current issue of The American Journal of Pathology.
May 22, 2017: American Journal of Pathology
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