Mariarita Caroleo, Elvira Anna Carbone, Biagio Arcidiacono, Marta Greco, Amedeo Primerano, Maria Mirabelli, Gilda Fazia, Marianna Rania, Marta Letizia Hribal, Luca Gallelli, Daniela Patrizia Foti, Pasquale De Fazio, Cristina Segura-Garcia, Antonio Brunetti
Nesfatin-1 is a new anorexigenic neuropeptide involved in the regulation of hunger/satiety, eating, and affective disorders. We aimed to investigate nesfatin-1 secretion in vitro, in murine adipose cells, and in human adipose fat samples, as well as to assess the link between circulating nesfatin-1 levels, NUCB2 and Fat Mass and Obesity Gene ( FTO ) polymorphisms, BMI, Eating Disorders (EDs), and pathological behaviors. Nesfatin-1 secretion was evaluated both in normoxic fully differentiated 3T3-L1 mouse adipocytes and after incubation under hypoxic conditions for 24 h...
January 10, 2023: Nutrients