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Living kidney donor

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https://www.readbyqxmd.com/read/29154680/cardiovascular-disease-predictors-and-adipose-tissue-macrophage-polarization-is-there-a-link
#1
Ivana Kralova Lesna, Marek Petras, Sona Cejkova, Anna Kralova, Jiri Fronek, Libor Janousek, Filip Thieme, Tomas Tyll, Rudolf Poledne
Background The risk of cardiovascular disease is closely connected to adipose tissue inflammation. The links between cardiovascular risk predictors and pro and anti-inflammatory macrophages in human adipose tissue were analysed to gain an insight into the pathophysiology of cardiovascular disease. Design Subcutaneous and visceral adipose tissues were obtained from 79 subjects, 52 living kidney donors (during nephrectomy) and 27 patients with peripheral artery disease (during arterial tree reconstruction). Methods Macrophage subsets were isolated from adipose tissues and analysed by flow cytometry using CD14, CD16, CD36 and CD163 monoclonal antibodies...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29150247/the-adoption-of-a-one-day-donor-assessment-model-in-a-living-kidney-donor-transplant-program-a-quality-improvement-project
#2
Judi M Graham, Aisling E Courtney
BACKGROUND: Survival of kidney transplants and their recipients is significantly better after living donor than after deceased donor transplantation. However, historically, Northern Ireland has had a low rate of living donor kidney transplantation. The length and complexity of donor evaluation has been one of the main factors contributing to this pattern. STUDY DESIGN: Quality improvement project. SETTINGS & PARTICIPANTS: All people in Northern Ireland expressing an interest in becoming a living kidney donor between 2010 and 2015...
November 14, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29149957/positive-and-negative-affects-in-living-kidney-donors
#3
C-Y Hsieh, C-H Chien, K-L Liu, H-H Wang, K-J Lin, Y-J Chiang
OBJECTIVE: This study aimed to identify the factors influencing the positive and negative affects and the health-related quality of life (HRQOL) of living kidney donors. METHODS: With the use of a cross-sectional study design and a structured questionnaire, information on the basic characteristics, positive affect, negative affect, and HRQOL of 41 living kidney donors were compared. RESULTS: The negative affect in living kidney donors was similar to that of the general population, but the positive affect was slightly lower...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149954/preoperative-risk-factors-associated-with-urinary-complications-after-kidney-transplantation
#4
T Bessede, Y Hammoudi, D Bedretdinova, B Parier, H Francois, A Durrbach, G Benoit
BACKGROUND: Only surgically irrelevant risk factors including sex, African-American ancestry, or exceptional U-stitch anastomosis have been identified to associate with urinary complications after kidney transplantation. The objective was to identify modifiable and nonmodifiable risk factors associated with urinary complications after kidney transplantation. METHODS: A single-center study of 3,129 kidney transplants performed over 40 years was conducted to identify independent risk factors using χ(2) tests and logistic regression analysis...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149952/financial-impact-of-incidental-radiologic-findings-during-living-kidney-donor-evaluation
#5
A Mutneja, L Saling, M Yano, A Vijayan
Living kidney donor (LKD) transplantation is an important alternative for the end-stage renal disease population and is preferred due to superior outcomes when compared with dialysis or deceased donor transplantation. LKD evaluation includes a computed tomography angiogram (CTA) for assessment of renal and renovascular anatomy. Incidental nonrenal findings are frequently noted during the CTAs, and these may have variable clinical significance. These incidental findings lead to further testing, procedures, and referrals, which incur additional cost...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149951/predictive-factors-of-renal-adaptation-after-nephrectomy-in-kidney-donors
#6
H J Kwon, D H Kim, H R Jang, S-H Jung, D H Han, H H Sung, J B Park, J E Lee, W Huh, S J Kim, Y-G Kim, D J Kim, H Y Oh
BACKGROUND: Despite compensatory hyperfiltration in remaining nephrons following donor nephrectomy, some donors show impaired renal adaptation and low estimated glomerular filtration rate (eGFR). We investigated the factors predicting early renal adaptation after nephrectomy and identified kidney donors at risk of inadequate renal adaptation. METHODS: A total of 265 living kidney donors from 2010 to 2013 were retrospectively analyzed. Renal function was serially followed for 6 months after the operation...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149950/structural-and-functional-adaptation-of-the-remnant-kidney-after-living-kidney-donation-long-term-follow-up
#7
M Meier, J Winterhoff, L Fricke, H Lehnert, M Nitschke
OBJECTIVE: Several adjustments occur after nephrectomy (NT) in the donor's remnant kidney. We investigated kidney donors 10 years after NT and compared several parameters before and after transplantation. METHODS: A total of 42 kidney donors of the University of Luebeck's Transplant Center were scheduled for a 10-year follow-up and were offered several investigations: laboratory tests, urinalysis and kidney ultrasound examination including determination of kidney volume (KV), resistive index (RI) and pulsatility index (PI)...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149947/impact-factors-and-attitudes-toward-organ-donation-among-transplantation-patients-and-their-caregivers-in-china
#8
Q-X Zhang, J-F Xie, J-D Zhou, S-S Xiao, A-Z Liu, G-Q Hu, Y Chen, C-Y Wang
PURPOSE: This study's purpose was to investigate the attitudes toward organ donation among renal transplantation patients and their caregivers. In addition, we sought to explore the impact factors that affect their attitudes toward deceased organ donation. DESIGN AND METHODS: A self-administrated questionnaire was used, which consisted of two parts: 1) demographic data, and 2) transplantation and donation-related data. This study was conducted in three transplantation follow-up centers in three hospitals using a cross-sectional approach...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29145879/allogeneic-mesenchymal-stem-cell-as-induction-therapy-to-prevent-both-delayed-graft-function-and-acute-rejection-in-deceased-donor-renal-transplantation-study-protocol-for-a-randomized-controlled-trial
#9
Qipeng Sun, Liangqing Hong, Zhengyu Huang, Ning Na, Xuefeng Hua, Yanwen Peng, Ming Zhao, Ronghua Cao, Qiquan Sun
BACKGROUND: Using kidneys from deceased donors is an available strategy to meet the growing need of grafts. However, higher incidences of delayed graft function (DGF) and acute rejection exert adverse effects on graft outcomes. Since ischemia-reperfusion injury (IRI) and ongoing process of immune response to grafts are the major causes of DGF and acute rejection, the optimal induction intervention should possess capacities of both repairing renal structure injury and suppressing immune response simultaneously...
November 16, 2017: Trials
https://www.readbyqxmd.com/read/29142988/proximal-tubular-expression-patterns-of-megalin-and-cubilin-in-proteinuric-nephropathies
#10
Jia Sun, Kjell Hultenby, Jonas Axelsson, Johan Nordström, Bing He, Annika Wernerson, Karin Lindström
Introduction: Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal tubules. For albumin this process involves at least 2 interacting receptors, megalin and cubilin. Albumin is not usually present in the urine, indicating a highly efficient tubular reuptake under physiological conditions. However, early appearance of albuminuria may mean that the tubular system is overwhelmed by large quantities of albumin or that the function is impaired. Methods: To better understand the physiological role of megalin and cubilin in human renal disease, renal biopsies from 15 patients with a range of albuminuria and 3 healthy living donors were analyzed for proximal tubular expression of megalin and cubilin using immunohistochemistry (IHC) and semiquantitative immune-electron microscopy...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29142981/commercial-kidney-transplantation-attitude-knowledge-perception-and-experience-of-recipients
#11
Fatma Al Rahbi, Issa Al Salmi
Introduction: Kidney transplantation is the gold standard for patients with end-stage kidney disease. In view of shortages of available organs, long wait times for possible transplantation, and strict regulation, many patients opt for commercial transplantation. This study elicits the reasons and motivations for patients with end-stage kidney disease to elect for commercial transplant. Methods: A questionnaire-based evaluation was conducted during the period from July 2015 until late December 2015...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29137595/study-of-bacterial-infections-among-patients-receiving-kidney-transplant-in-mashhad-iran
#12
Davood Mansury, Azad Khaledi, Kiarash Ghazvini, Mahin Ghorban Sabbagh, Hosna Zare, Mohammad Hossein Rokni-Hosseini, Hossein Vazini
OBJECTIVES: Over the past 2 decades, significant advances have been made in the management of infections after transplant; however, transplant recipients are still at high risk of infectious complications. This study aimed to evaluate the prevalence of bacterial infections and antimicrobial resistance patterns in kidney transplant recipients. MATERIALS AND METHODS: This cross-sectional study included 356 patients who received kidney transplants, regardless of the underlying disease, from 2013 to 2015 at the Montaserieh Transplant Hospital (Mashhad, Iran)...
November 15, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29133549/pharmacokinetics-and-exposure-response-analysis-of-rg7667-a-combination-of-two-anti-cytomegalovirus-monoclonal-antibodies-in-a-phase-2a-randomized-trial-to-prevent-cytomegalovirus-infection-in-high-risk-kidney-transplant-recipients
#13
Rong Deng, Yehong Wang, Mauricio Maia, Tracy Burgess, Jacqueline M McBride, X Charlene Liao, Jorge A Tavel, William D Hanley
BACKGROUND: RG7667, a novel combination of two anti-cytomegalovirus (CMV) monoclonal IgG1 antibodies (MCMV5322A and MCMV3068A), was designed to block CMV entry into host cells. It was developed as a potential therapy for preventing CMV infection and disease in transplant recipients. METHODS: In a Phase 2a trial in CMV-seronegative recipients of kidney transplants from CMV-seropositive donors, RG7667 was assessed for preventing CMV infection. Patients received 4 intravenous doses of RG7667 (10 mg/kg of each antibody, n=60) or placebo (n=60) at time of transplant, and 1, 4, and 8 weeks post transplant...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29130538/-what-if-this-is-my-chance-to-save-my-life-a-semi-structured-interview-study-on-the-motives-and-experiences-of-esrd-patients-who-engaged-in-public-solicitation-of-a-living-kidney-donor
#14
Mathilde C Pronk, Dorthe Slaats, Willij C Zuidema, Medard T Hilhorst, Frank J M F Dor, Michiel Betjes, Willem Weimar, Jacqueline van de Wetering, Emma K Massey
The increase of patients using public solicitation (PS) to find a living kidney donor has generated a debate about the ethical complexities of PS. To investigate why patients engaged in PS and what they experienced during PS we conducted semi-structured interviews with 20 Dutch end-stage renal disease patients who had publicly solicited a living donor. Transcipts were thematically analyzed. We identified ten themes on patients' considerations preceding PS: cautiousness in discussing living donation within social network; reluctance to accept a kidney from loved ones; rejection/withdrawal of related donor candidates; moral objections to black market organs/paid donation; the ease of social media; encouraged by others; ends justyfying the means; despair and urge to take action; public disclosure of vulnerability; fear of being (perceived to be) selfish...
November 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29129387/socio-sanitary-profile-and-information-for-living-kidney-donors-and-recipients-in-three-andalusian-hospitals
#15
Manuel-Ángel Calvo-Calvo, Isabel Morgado Almenara, Miguel Ángel Gentil Govantes, Andrés Moreno Rodríguez, Teresa Puertas Cruz, Teresa García Álvarez, María Dolores Carmona Vílchez
BACKGROUND: Information provided by health professionals to potential donors and recipients is essential for an autonomous and objective decision to make a living kidney donation. OBJECTIVES: To determine the characteristics of the information received by living kidney donors and recipients, to find out their socio-sanitary profile, their socio-demographics, financial and labour characteristics, health and the caregiving activity of these donors and recipients. METHODS: Observational, descriptive and cross-sectional study of the population of living kidney donors and recipients from the University Hospitals Puerta del Mar (Cádiz), Virgen del Rocío (Seville), and the University Hospital Complex of Granada, between 08/04/2014 and 08/06/2015...
November 9, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29128413/association-of-citizenship-status-with-kidney-transplantation-in-medicaid-patients
#16
Jenny I Shen, Daniel Hercz, Lilly M Barba, Holly Wilhalme, Erik L Lum, Edmund Huang, Uttam Reddy, Leslie Salas, Sitaram Vangala, Keith C Norris
BACKGROUND: Although individuals classified as nonresident aliens, including undocumented immigrants, are entitled to receive emergency dialysis in the United States regardless of their ability to pay, most states do not provide them with subsidized care for maintenance dialysis or kidney transplantation. We explored whether nonresident aliens have similar outcomes to US citizens after receiving kidney transplants covered by Medicaid, a joint federal and state health insurance program...
November 8, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29123936/reconstruction-of-a-damaged-lower-polar-artery-for-kidney-transplantation-using-tubularised-donor-aorta
#17
A J Vicéns-Morton, C Callaghan, J Olsburgh
Introduction: Live donors, extended donor criteria, and the maximum usage of organs with anatomical variants are some of the mechanisms used to increase the number of organs available. Case: We present the case of a kidney transplant, in which the organ had an iatrogenic injury to a lower pole arterial branch during retrieval. The donor was a 35-year-old male (DCD, Maastricht III). The right kidney was accepted; it had three veins in a single cava patch and three renal arteries, the main artery with aorta patch that is 8 cm long...
2017: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29118534/pure-retroperitoneoscopic-donor-nephrectomy-in-duplication-of-inferior-vena-cava-a-series-of-four-cases
#18
Bipin Chandra Pal, Pranjal R Modi, Syed Jamal Rizvi, Rohit Chauhan, Suresh Kumar, Shruti P Gandhi, Vivek B Kute, Hargovind L Trivedi
Aim: Complex vascular anatomy poses a major challenge to the donor surgeon. Here, we have described the technical nuances in retroperitoneoscopic living donor nephrectomy for the left kidney in the situations of a rare vascular anomaly of duplication of inferior vena. Materials and Methods: Between September 2005 and June 2016, 1460 retroperitoneoscopic living donor nephrectomy were carried out in single surgical unit of our institution. Out of these four donors were found to have duplication of inferior vena cava (IVC)...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29113092/recipient-hla-g-3142-cc-genotype-and-concentrations-of-soluble-hla-g-impact-on-occurrence-of-cmv-infection-after-living-donor-kidney-transplantation
#19
Hana Guberina, Rafael Tomoya Michita, Sebastian Dolff, Anja Bienholz, Mirko Trilling, Falko M Heinemann, Peter A Horn, Andreas Kribben, Oliver Witzke, Vera Rebmann
The expression modulation of the immunosuppressive non-classical Human leukocyte antigen-G (HLA-G) molecule and its soluble isoforms is an immune evasion strategy being deployed by cytomegalovirus (CMV). The +3142 C>G single nucleotide polymorphism (SNP) located within the 3' untranslated region (3'UTR) is of crucial importance for the regulation of HLA-G expression. Therefore, we analyzed the influence of the +3142 C>G HLA-G SNP on the occurrence of CMV infection in a cohort of 178 living-donor kidney recipients and their 178 corresponding donors...
November 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29110763/clinical-genetic-testing-for-apol1-are-we-there-yet
#20
REVIEW
Bessie A Young, Stephanie Malia Fullerton, James G Wilson, Kerri Cavanaugh, Erika Blacksher, Clarence Spigner, Jonathan Himmelfarb, Wylie Burke
End-stage renal disease (ESRD) disproportionately affects African Americans, who are two to four times more likely than European Americans to develop ESRD. Two independent variants of the apolipoprotein L1 (APOL1) gene, G1 and G2, have been associated with a 7- to 10-fold greater risk of developing nondiabetic ESRD in African Americans. Those who inherit two risk variants (G1/G1, G2/G2, or G1/G2) are also more likely to develop ESRD at a younger age and to have progression of chronic kidney disease. Currently, it is not known what proportion of persons with high-risk genotypes will develop ESRD in the general population, the exact mechanism of injury for APOL1-related risk, its relation to environmental exposures, or whether patients with comorbid conditions are more likely to develop ESRD...
November 2017: Seminars in Nephrology
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