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https://www.readbyqxmd.com/read/29786594/-brain-microbleeds-definition-pathophysiology-and-the-consequences
#1
Marek Mazurek, Ewa Papuć, Konrad Rejdak
Brain microbleeds are defined as small, circular hypointense changes in T2-sequensec of brain MRI, well demarcated from the surrounding tissue. They represent the phagocytized products of blood distribution extravasated from pathologically altered vessels. The echo-T2-dependent gradient (GRE) and magnetic susceptibility testing (SWI) sequences are usually used to visualize them. The pathogenesis of microbleeds very complex but angiopathy associated with arterial hypertension and cerebral amyloid angiopathy play a special role...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29785596/biochar-reduces-nitrate-level-in-red-beet
#2
Josef Maroušek, Ladislav Kolář, Marek Vochozka, Vojtěch Stehel, Anna Maroušková
Impacts of red beet consumption both on human and animal health are subject of intense research. In particular, products that are not heat-processed contain plethora of bioactive compounds that hold promise against numerous degenerative and aging-associated diseases. However, high level of nitrates (typically more than 2 g NO3 - kg-1 ) whose health effects are perceived with reasoned objections counterbalance these benefits. Following the above, from a certain level, the increased consumption of red beet has contrary impacts, creating a limiting factor not only from the economic point of view but also in terms of beneficial compounds intake...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785097/inter-gender-differences-of-balance-indicators-in-persons-60-90-years-of-age
#3
Ewa Puszczalowska-Lizis, Przemyslaw Bujas, Slawomir Jandzis, Jaroslaw Omorczyk, Marek Zak
Introduction: Precision of movements responsible for maintaining balance deteriorates with age due to natural involutionary processes, thus prompting a research question whether the values of gender-related stability indicators might differ significantly among the study subjects over 60 years of age. Methods: The study group comprised 136 seniors (89 women, 47 men; aged 60-90 years). The CQ-Stab 2P 2-platform posturograph was used as the main research device, whereas the Mann-Whitney U -test was used to evaluate the gender-related differences in the average level of variables...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29784352/application-of-gradient-ratio-flow-injection-technique-to-implementation-of-the-chemical-h-point-standard-addition-method
#4
Marcin Wieczorek, Marek Dębosz, Paweł Świt, Aneta Woźniakiewicz, Paweł Kościelniak
A new gradient ratio approach to Chemical H-point Standard Addition Method (C-HPSAM) was developed in flow injection analysis with spectrophotometric detection. C-HPSAM is based on an idea to use SAM for calibration in several different chemical conditions in order to correct unspecific (additive) interferences in samples with unknown matrix. The approach proposed in this paper employs the gradient ratio flow-injection technique to generate a continuous change of chemical conditions. By doing so a set of two-point SAM calibration curves with different slopes are possible of registering that are intersected in a common point indicating the values of both unspecific interferences and analyte concentration in a sample...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783774/d-amino-acid-peptide-residualizing-agents-for-protein-radioiodination-effect-of-aspartate-for-glutamate-substitution
#5
Marek Pruszynski, Choong Mo Kang, Eftychia Koumarianou, Ganesan Vaidyanathan, Michael R Zalutsky
The residualizing prosthetic agent N ε -(3-[* I]iodobenzoyl)-Lys⁵- N α -maleimido-Gly¹-d-GEEEK ([* I]IB-Mal-d-GEEEK) showed promise for the radioiodination of monoclonal antibodies (mAbs) that bind to internalizing molecular targets. Although enhanced tumor uptake was achieved in these studies, elevated kidney accumulation also was observed, particularly with low-molecular-weight, single-domain antibody fragments (sdAbs). Here, we developed an analogous agent (IB-Mal-d-GDDDK), in which glutamate residues (E) were replaced with aspartates (D) to determine whether this modification could decrease renal uptake...
May 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29783754/silicon-influences-soil-availability-and-accumulation-of-mineral-nutrients-in-various-plant-species
#6
Maria Greger, Tommy Landberg, Marek Vaculík
Silicon (Si) effects on mineral nutrient status in plants are not well investigated. It is known that Si has a beneficial effect on plants under stressed conditions. The aim was to make a state of the art investigation of the Si influence: (1) on nutrient availability in four different soil types, namely clayish, sandy, alum shale and submerged soil; and (2) on accumulation of various nutrients in maize, lettuce, pea, carrot and wheat growing in hydroponics. Soil was treated with K₂SiO₃ corresponding to 80 and 1000 kg Si ha-1 and the nutrient medium with 100, 500, 1000 and 5000 μM Si...
May 19, 2018: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29783672/synergistic-viral-replication-of-marek-s-disease-virus-and-avian-leukosis-virus-subgroup-j-is-responsible-for-the-enhanced-pathogenicity-in-the-superinfection-of-chickens
#7
Jing Zhou, Guo-Liang Zhao, Xiao-Man Wang, Xu-Sheng Du, Shuai Su, Chen-Gui Li, Venugopal Nair, Yong-Xiu Yao, Zi-Qiang Cheng
Superinfection of Marek's disease virus (MDV) and avian leukosis virus subgroup J (ALV-J) causes lethal neoplasia and death in chickens. However, whether there is synergism between the two viruses in viral replication and pathogenicity has remained elusive. In this study, we found that the superinfection of MDV and ALV-J increased the viral replication of the two viruses in RNA and protein level, and synergistically promoted the expression of IL-10, IL-6, and TGF-β in chicken embryo fibroblasts (CEF). Moreover, MDV and ALV-J protein expression in dual-infected cells detected by confocal laser scanning microscope appeared earlier in the cytoplasm and the nucleus, and caused more severe cytopathy than single infection, suggesting that synergistically increased MDV and ALV-J viral-protein biosynthesis is responsible for the severe cytopathy...
May 18, 2018: Viruses
https://www.readbyqxmd.com/read/29782388/glasgow-coma-scale-score-fluctuations-are-inversely-associated-with-a-nirs-based-index-of-cerebral-autoregulation-in-acutely-comatose-patients
#8
Ryan J Healy, Andres Zorrilla-Vaca, Wendy Ziai, Marek A Mirski, Charles W Hogue, Romergryko Geocadin, Batya Radzik, Caitlin Palmisano, Lucia Rivera-Lara
BACKGROUND: The Glasgow Coma Scale (GCS) is an essential coma scale in critical care for determining the neurological status of patients and for estimating their long-term prognosis. Similarly, cerebral autoregulation (CA) monitoring has shown to be an accurate technique for predicting clinical outcomes. However, little is known about the relationship between CA measurements and GCS scores among neurological critically ill patients. This study aimed to explore the association between noninvasive CA multimodal monitoring measurements and GCS scores...
May 18, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29782381/high-baseline-neutrophil-to-lymphocyte-ratio-predicts-worse-outcome-in-patients-with-metastatic-braf-positive-melanoma-treated-with-braf-and-mek-inhibitors
#9
Paweł Teterycz, Paulina Jagodzińska-Mucha, Bożena Cybulska-Stopa, Anna Mariuk-Jarema, Katarzyna Kozak, Hanna Koseła-Paterczyk, Anna M Czarnecka, Marcin Rajczykowski, Robert Dziura, Łukasz Galus, Jacek Mackiewicz, Tomasz Świtaj, Anna Klimczak, Slawomir Falkowski, Rafał Suwiński, Marek Ziobro, Iwona Ługowska, Piotr Rutkowski
Neutrophil-to-lymphocyte ratio (NLR) has been shown to be prognostic in several solid malignancies. There are limited data regarding its value during novel therapies in patients with melanoma. The aim of the study was to assess the practical utility of this ratio in patients with BRAF-mutant melanoma treated with a combination of BRAF and MEK inhibitors (BRAFi/MEKi). We included 215 patients with inoperable or metastatic melanoma who underwent BRAFi/MEKi treatment between October 2015 and June 2017. Baseline NLR and other complete blood count-derived inflammatory markers were tested for association with overall survival and progression-free survival in univariate and multivariate models...
May 18, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29782294/the-value-of-high-frequency-20-mhz-ultrasonography-for-preoperative-measurement-of-cutaneous-melanoma-thickness
#10
Andrea Kozárová, Marek Kozár, Ingrid Tonhajzerová, Táňa Pappová, Eva Minariková
High-frequency ultrasonography has become an important diagnostic tool in dermatovenerology. It is used for assessment of the cutaneous layers in diverse benign and malignant skin lesions and diseases. Herein we present the practical value of preoperative measurement of cutaneous melanoma thickness, the explanation of the possible reasons for different sonographic and histologic Breslow thickness, and the practical importance of high-frequency 20 MHz ultrasonography in preoperative measurements of cutaneous melanoma thickness...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781447/singlet-and-triplet-trions-in-ws-sub-2-sub-monolayer-encapsulated-in-hexagonal-boron-nitride
#11
Diana Vaclavkova, Jan Wyzula, Karol Nogajewski, Miroslav Bartos, Artur Slobodeniuk, Clément Faugeras, Marek Potemski, Maciej Molas
Embedding a WS<sub>2</sub> monolayer in flakes of hexagonal boron nitride allowed
 us to resolve and study the photoluminescence response due to both singlet and triplet
 states of negatively charged excitons (trions) in this atomically thin semiconductor.
 The energy separation between the singlet and triplet states has been found to
 be relatively small reflecting rather weak effects of the electron-electron exchange
 interaction for the trion triplet in a WS<sub>2</sub> monolayer, which involves two electrons
 with the same spin but from different valleys...
May 21, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29781075/effectiveness-of-gabapentin-pharmacotherapy-in-chemotherapy-induced-peripheral-neuropathy
#12
Magdalena Magnowska, Natalia Iżycka, Joanna Kapoła-Czyż, Anna Romała, Jakub Lorek, Marek Spaczyński, Ewa Nowak-Markwitz
OBJECTIVES: Chemotherapy-induced peripheral neuropathy (CIPN) is a common chemotherapy side effect, but its prevention and treatment remains a challenge. Neurotoxicity may lead to dose limitation or even treatment discontinuation, and therefore potentially affect the efficacy of anticancer treatment and long term outcomes. The practice to administer gabapentin for neuropathy may be applicable, but is limited by insufficient studies. The aim of our study was to assess the presence of chemotherapy-induced peripheral neuropathy in ovarian cancer patients treated with first-line paclitaxel and carboplatin chemotherapy and evaluate the effectiveness of gabapentin in treatment of this condition...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29778237/prevalence-temporal-evolution-and-impact-on-survival-of-ventricular-conduction-blocks-in-patients-with-acute-coronary-syndrome-and-cardiogenic-shock
#13
Heli Tolppanen, Tuija Javanainen, Jordi Sans-Rosello, Jiri Parenica, Tuomo Nieminen, Marie Pavlusova, Josep Masip, Lars Köber, Marek Banaszewski, Alessandro Sionis, Jindrich Spinar, Veli-Pekka Harjola, Raija Jurkko, Johan Lassus
Changes in QRS duration and pattern are regarded to reflect severe ischemia in acute coronary syndromes (ACS), and ventricular conduction blocks (VCBs) are recognized high-risk markers in both ACS and acute heart failure. Our aim was to evaluate the prevalence, temporal evolution, association with clinical and angiographic parameters, and impact on mortality of VCBs in ACS-related cardiogenic shock (CS). Data of 199 patients with ACS-related CS from a prospective multinational cohort were evaluated with electrocardiogram data from baseline and day 3...
April 20, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29777685/thiamine-preserves-mitochondrial-function-in-a-rat-model-of-traumatic-brain-injury-preventing-inactivation-of-the-2-oxoglutarate-dehydrogenase-complex
#14
Garik V Mkrtchyan, Muammer Üçal, Andrea Müllebner, Sergiu Dumitrescu, Martina Kames, Rudolf Moldzio, Marek Molcanyi, Samuel Schaefer, Adelheid Weidinger, Ute Schaefer, Juergen Hescheler, Johanna Catharina Duvigneau, Heinz Redl, Victoria I Bunik, Andrey V Kozlov
BACKGROUND AND PURPOSE: Based on the fact that traumatic brain injury is associated with mitochondrial dysfunction we aimed at localization of mitochondrial defect and attempted to correct it by thiamine. EXPERIMENTAL APPROACH: Interventional controlled experimental animal study was used. Adult male Sprague-Dawley rats were subjected to lateral fluid percussion traumatic brain injury. Thiamine was administered 1 h prior to trauma; cortex was extracted for analysis 4 h and 3 d after trauma...
May 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29777121/magneto-absorption-spectra-of-hydrogen-like-yellow-exciton-series-in-cuprous-oxide-excitons-in-strong-magnetic-fields
#15
Sergey Artyukhin, Dmitry Fishman, Clément Faugeras, Marek Potemski, Alexandre Revcolevschi, Maxim Mostovoy, Paul H M van Loosdrecht
We study the absorption spectra of the yellow excitons in Cu2 O in high magnetic fields using polarization-resolved optical absorption measurements with a high frequency resolution. We show that the symmetry of the yellow exciton results in unusual selection rules for the optical absorption of polarized light and that the mixing of ortho- and para- excitons in magnetic field is important. The calculation of the energies of the yellow exciton series in strong and weak magnetic field limits suggests that a broad n = 2 line is comprized by two closely overlapping lines, gives a good fit to experimental data and allows to interpret the complex structure of excitonic levels...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29775917/difficulties-in-interpretation-when-assessing-prolonged-and-subacute-exposure-to-the-toxic-effects-of-chlorine
#16
Marek Wiergowski, Ireneusz Sołtyszewski, Jacek Sein Anand, Michał Kaliszan, Jolanta Anita Wilmanowska, Zbigniew Jankowski, Marcin Łukasik
The purpose of this study was a toxicological interpretation of exposure to chlorine with unusual course. Medical, clinical and court records, as well as reviews of the literature, served as the basis for this interpretation. The first case of poisoning concerns a 52-year-old man who for a short time (probably several hours), during the industrial cleaning of facilities with sodium hypochlorite, was exposed to chlorine in a presumed high concentration. The man was obese and suffered from hypertension and moderate atherosclerosis, and therefore could be more susceptible to the toxic effects of chlorine...
May 8, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29775855/dual-core-all-fiber-integrated-immunosensor-for-detection-of-protein-antigens
#17
Karol Wysokiński, Dawid Budnicki, Janusz Fidelus, Łukasz Szostkiewicz, Łukasz Ostrowski, Micha Murawski, Marcin Staniszewski, Magdalena Staniszewska, Marek Napierała, Tomasz Nasiłowski
An optical fiber interferometric microprobe for detection of specific proteins is presented in this paper. The microprobe is an all-fiber device, which is based on Michelson interferometer configuration, which allows for detection of protein antigens in an analyzed solution thanks to antibodies immobilized on the sensor surface. The interferometer is made of dual core fiber and has a precisely formed arm length difference, achieved by splicing a fragment of polarization maintaining fiber to one of the cores...
May 9, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29775424/optimized-yeast-based-in-vitro-bioassay-for-determination-of-estrogenic-and-androgenic-activity-of-hydroxylated-methoxylated-metabolites-of-bdes-cbs-and-related-lipophilic-organic-pollutants
#18
Marek Roszko, Marta Kamińska, Krystyna Szymczyk, Katarzyna Piasecka-Jóźwiak, Beata Chabłowska
Persistent organic pollutants (POPs) are known to show endocrine disrupting (ED) activity, including interactions with hormone receptors. The aim of this work was to develop a bioassay applicable for evaluation of ED potency of highly lipophilic metabolites of POPs. To that end, a yeast-based bio-assay protocol was used. Estrogenic / androgenic activity of some native brominated biphenyl ethers (BDEs) / chlorinated biphenyls (CBs), and their hydroxylated / methoxylated metabolites was assessed. Since data (including potency compared to reference native hormones) obtained using different protocols vary, the possibility that yeast transforms POPs into some more potent compounds was first checked; it seems that no such transformation is important from the test applicability standpoint...
May 18, 2018: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/29775150/computer-aided-analysis-of-middle-cerebral-artery-tortuosity-association-with-aneurysm-development
#19
Kornelia M Kliś, Roger M Krzyżewski, Borys M Kwinta, Krzysztof Stachura, Marek Moskała, Krzysztof A Tomaszewski
OBJECTIVE Blood vessel tortuosity may play an important role in the development of vessel abnormalities such as aneurysms. Currently, however, there are no studies analyzing the impact of brain blood vessel tortuosity on the risk of aneurysm formation. Therefore, the authors performed a computer-aided analysis of middle cerebral artery (MCA) tortuosity, especially among patients diagnosed with MCA aneurysms. METHODS Anatomy of the MCAs of 54 patients with unruptured MCA aneurysms was retrospectively analyzed, as was that of 54 sex-, age-, and vessel side-matched control patients without MCA aneurysms...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29773836/novel-pathway-of-3-hydroxyanthranilic-acid-formation-in-limazepine-biosynthesis-reveals-evolutionary-relation-between-phenazines-and-pyrrolobenzodiazepines
#20
Magdalena Pavlikova, Zdenek Kamenik, Jiri Janata, Stanislav Kadlcik, Marek Kuzma, Lucie Najmanova
Natural pyrrolobenzodiazepines (PBDs) form a large and structurally diverse group of antitumour microbial metabolites produced through complex pathways, which are encoded within biosynthetic gene clusters. We sequenced the gene cluster of limazepines and proposed their biosynthetic pathway based on comparison with five available gene clusters for the biosynthesis of other PBDs. Furthermore, we tested two recombinant proteins from limazepine biosynthesis, Lim5 and Lim6, with the expected substrates in vitro...
May 17, 2018: Scientific Reports
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