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https://www.readbyqxmd.com/read/29022963/tuberculous-osteomyelitis-of-orbit-a-case-report
#1
Chandana Chakraborti, Krittika Pal Choudhury, Jayanta Das
BACKGROUND: Orbital tuberculosis is a rare manifestation of extrapulmonary tuberculosis. We report an interesting case of osteomyelitis of orbital bone in an Indian child. CASE REPORT: A 9- year old girl presented with a gradually increasing painless swelling of left upper lid and blepharoptosis along with swelling of left side of forehead for last two months. The swelling was soft, fluctuating and non-tender. Diagnostic tap revealed thick pus which prompted us to do an incisional drainage of the abscess...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29017946/cloning-and-expression-of-malabar-grouper-epinephelus-malabaricus-adar1-gene-in-response-to-immune-stimulants-and-nervous-necrosis-virus
#2
Thirunavukkarasu Periyasamy, Joan Tang Xiao Joe, Ming-Wei Lu
ADARs are RNA editing catalysts that bind double-stranded RNA and convert adenosine to inosine, a process that can lead to destabilization of dsRNA structures and suppression of mRNA translation. In mammals, ADAR1 genes are involved in various cellular pathways, including interferon (IFN)-mediated response. However, the function of fish ADAR1 remains unclear. We report here the cloning of ADAR1 in Malabar grouper (Epinephelus malabaricus) (MgADAR1) and its response to various immune stimulants. The MgADAR1 cDNA is 5371-bp long, consisting of an open reading frame encoding a putative protein of 1381 amino acids, a 235-nt 5'-terminal untranslated region (UTR), and a 990-nt 3'-UTR...
October 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29017941/novel-ifn%C3%AE-homologue-identified-in-nile-tilapia-oreochromis-niloticus-links-with-immune-response-in-gills-under-different-stimuli
#3
Janet Velázquez, Jannel Acosta, Naylin Herrera, Antonio Morales, Osmany González, Fidel Herrera, Mario Pablo Estrada, Yamila Carpio
Interferon gamma (IFN-γ) has important roles in both innate and adaptive immune responses. This cytokine plays a very important role in defining Th1 immune response in all vertebrates. In the present study, we identified and isolated for the first time the gene coding for Nile tilapia (Oreochromis niloticus) IFNγ from spleen lymphocytes. The isolated tilapia IFNγ has between 23 and 62% of amino acid identity as compared to reported sequences for other teleost fishes. It has close phylogenetic relationships with IFNγ molecules belonging to the group of Perciforms and presents the typical structural characteristics of gamma interferon molecules...
October 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28990530/isoform-separation-by-a-mixed-mode-resin-toyopearl-mx-trp-650m
#4
Tsutomu Arakawa
TOYOPEARL particles are cross-linked hydroxylated methacrylic polymers available in different pore and particle sizes. They are conjugated with different ligands to generate ion-exchange, hydrophobic interaction and affinity resins. They have excellent physical and chemical properties. A mixed-mode resin, TOYOPEARL MX-Trp-650M, is made of this particle with tryptophan conjugated via N-terminal amino group and hence has both hydrophobic/aromatic side chain and carboxyl group. In this review, I will summarize the properties of the TOYOPEARL particles and MX-Trp-650M resin and application of this resin for purification of proteins and in some detail the separation of disulfide (SS)-scrambled oligomers of insulin-like growth factor-1 (IGF-1)...
October 9, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28988797/altered-expression-of-interferon-stimulated-genes-is-strongly-associated-with-therapeutic-outcomes-in-hepatitis-b-virus-infection
#5
Meifang Han, Yong Li, Wenyu Wu, Yuanya Zhang, Weiming Yan, Xiaoping Luo, Qin Ning
Our previous OSST study shows that switching to pegylated interferon (Peg-IFN)-α2a results in higher rates of response hepatitis B e antigen (HBeAg) seroconversion and hepatitis B surface antigen (HBsAg) loss at the end of treatment, compared with nucleot(s)ide analogues (NAs) monotherapy in long term NA-treated chronic hepatitis B (CHB) patients. In order to characterize the correlation between Peg-IFN-α antiviral effect and IFN-inducing signaling in CHB patients who switched to Peg-IFN from long time entecavir (ETV) treatment, we investigated the dynamic expression of interferon-stimulated genes (ISGs), including STAT1, MX, and a negative regulatory factor, suppressor of cytokine signaling 3(SOCS3), which negatively regulate IFN JAK-STAT signaling pathway by interacting with STAT1 and STAT2, in peripheral blood and paired liver samples, obtained from 54 CHB patients enrolled in a clinical trial, OSST study...
October 6, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28986216/innate-immune-responses-against-rock-bream-iridovirus-rbiv-infection-in-rock-bream-oplegnathus-fasciatus-following-poly-i-c-administration
#6
Myung-Hwa Jung, Sung-Ju Jung
Poly (I:C) showed promise as an immunoprotective agents in rock bream against rock bream iridovirus (RBIV) infection. In this study, we evaluated the time-dependent virus replication pattern and antiviral immune responses in RBIV-infected rock bream with and without poly (I:C) administration. In the poly (I:C)+virus-injected group, virus copy numbers were more than 18.9-, 24.0- and 479.2-fold lower than in the virus only injected group at 4 (4.73 × 10(4) and 8.95 × 10(5)/μl, respectively), 7 (3.67 × 10(5) and 8...
October 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28982477/sorption-of-three-synthetic-musks-by-microplastics
#7
Xiaojun Zhang, Minggang Zheng, Ling Wang, Yinghua Lou, Lei Shi, Shujun Jiang
Microplastics and synthetic musks (SMs) are two typical organic pollutants in the marine environment. In this study, the sorption of three SMs to microplastics in a simulated seawater environment was examined. Tonalide (AHTN), musk xylene (MX), and musk ketone (MK) were the musks investigated, while polypropylene (PP) was used as the microplastic. It was found that the equilibrium sorption time was about 10h and the adsorption kinetics model conformed to a Lagergren adsorption model. The adsorption capacity increased with decreasing particle size...
October 2, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28957252/microchip-yb-calnalo4-lasers-with-up-to-91-slope-efficiency
#8
Pavel Loiko, Josep Maria Serres, Xavier Mateos, Xiaodong Xu, Jun Xu, Venkatesan Jambunathan, Petr Navratil, Antonio Lucianetti, Tomas Mocek, Xuzhao Zhang, Uwe Griebner, Valentin Petrov, Magdalena Aguiló, Francesc Díaz, Arkady Major
Multi-watt continuous-wave (CW) operation of tetragonal rare-earth calcium aluminate Yb:CaLnAlO4(Ln=Gd,Y)) crystals in plano-plano microchip lasers was demonstrated with an almost quantum-defect-limited slope efficiency. Pumped at 978 nm by an InGaAs laser diode, a 3.4 mm long 8 at. % Yb:CaGdAlO4 laser generated 7.79 W at 1057-1065 nm with a slope efficiency of η=84% (with respect to the absorbed pump power). An even higher η=91% was achieved with a 2.5 mm long 3 at. % Yb:CaYAlO4 laser, from which 5...
July 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28942111/open-source-software-euroformix-can-be-used-to-analyse-complex-snp-mixtures
#9
Øyvind Bleka, Mayra Eduardoff, Carla Santos, Chris Phillips, Walther Parson, Peter Gill
A series of two- and three-person mixtures of varying dilutions were prepared and analysed with Life Technologies' HID-Ion AmpliSeq™ Identity Panel v2.2 using the Ion PGM™ massively parallel sequencing (MPS) system. From this panel we used 134 autosomal SNPs. Using the reference samples of three donors, we evaluated the strength of evidence with likelihood ratio (LR) calculations using the open-source quantitative EuroForMix program and compared the results with a previous study using a qualitative software (LRmix)...
August 18, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28923314/a-simple-method-for-isolation-of-cell-associated-viral-particles-from-cell-culture
#10
Katarina Laposova, Ingrid Oveckova, Jana Tomaskova
A common method for cell-associated virus isolation involves disruption of infected cells by a combination of hypotonic burst, freeze-thaw cycles (F-T) and sonication. This protocol was also originally used for the preparation of cell-free extract containing the MX strain of lymphocytic choriomeningitis virus (LCMV), which is preferentially propagated by cell-to-cell contact and does not release distinct virions into the medium. In the present study, we compared different approaches to virus isolation. Based on virus yield, we show that deionized water lysis is the fastest and most effective method for releasing LCMV MX infectious viral particles from persistently infected cells...
November 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28910928/-a-twin-study-of-genetic-and-environmental-influences-on-relationship-between-attention-deficit-and-anxiety-depression-in-children-and-adolescents
#11
S S Wang, T J Chen, C Y Ji
Objective: To understand the genetic and environmental influences on the relationship between attention deficit and anxiety/depression in children and adolescents. Methods: A total of 1 062 same-sex twins aged 6-18 years were included in this study. A parent-rated child behavior checklist (CBCL) was used in the assessment. Software Mx was used to fit the univariate model of structural equation. The relationship between attention deficit and anxiety/depression was analyzed through bivariate genetic modeling...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28910320/differential-gene-expression-following-tlr-stimulation-in-rag1-mutant-zebrafish-tissues-and-morphological-descriptions-of-lymphocyte-like-cell-populations
#12
Preeti J Muire, Larry A Hanson, Robert Wills, Lora Petrie-Hanson
In the absence of lymphocytes, rag1-/- mutant zebrafish develop protective immunity to bacteria. In mammals, induction of protection by innate immunity can be mediated by macrophages or natural killer (NK) cells. To elucidate potential responsive cell populations, we morphologically characterized lymphocyte-like cells (LLCs) from liver, spleen and kidney hematopoietic tissues. In fish, these cells include NK cells and Non-specific cytotoxic cells (NCCs). We also evaluated the transcriptional expression response of select genes that are important indicators of NK and macrophage activation after exposure to specific TLR ligands...
2017: PloS One
https://www.readbyqxmd.com/read/28901176/an-evaluation-of-the-effectiveness-of-the-national-aeronautics-and-space-administration-mission-x-child-health-promotion-program-in-the-united-states
#13
Jungwon Min, Zhengqi Tan, Laurie Abadie, Scott Townsend, Hong Xue, Youfa Wang
PURPOSE: To examine the effects of the National Aeronautics and Space Administration Mission-X: Train Like an Astronaut program (MX) on children's health-related knowledge and behaviors of a sample of US participants. DESIGN: A nonexperimental pilot intervention study in 5 cities with a pre-post comparison of children's health-related knowledge and behaviors in the United States in 2014 and 2015. SAMPLE: Children (n = 409) with a mean age (standard deviation) of 10...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28895871/type-i-interferons-in-the-pathogenesis-and-treatment-of-canine-diseases
#14
REVIEW
Daniela Klotz, Wolfgang Baumgärtner, Ingo Gerhauser
Type I interferons (IFNs) such as IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω represent cytokines, which are deeply involved in the regulation and activation of innate and adaptive immune responses. They possess strong antiviral, antiproliferative, and immunomodulatory activities allowing their use in the therapy of different viral diseases, neoplasms, and immune-mediated disorders, respectively. Initially, treatment strategies were based on nonspecific inducers of type I IFNs, which were soon replaced by different recombinant proteins...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28888122/interferon-%C3%AF-induced-gene-expression-in-bovine-hepatocytes-during-early-pregnancy
#15
B Ruhmann, K Giller, A K Hankele, S E Ulbrich, M Schmicke
Interferon-tau (IFNτ) is the conceptus derived specific early pregnancy signal in bovidae. Locally, IFNτ induces an IFNτ specific gene expression (ISG) in endometrial cells and by this it averts luteolysis of the corpus luteum (CL) by suppressing prostaglandin production. Moreover, it was shown that IFNτ also induces ISG in the liver in pregnant sheep and in liver biopsies from Holstein Friesian heifers on Day 18 of pregnancy. The objective of the present study was to confirm increased hepatic ISG in vivo on Day 18 of pregnancy and to prove if hepatocytes and not non-parenchymal cells react to IFNτ by using immunohistochemistry and primary bovine hepatocytes stimulated in vitro with recombinant bovine IFNτ...
July 31, 2017: Theriogenology
https://www.readbyqxmd.com/read/28882976/endobronchial-carcinoid-tumor-totally-occluding-the-left-main-bronchus-without-producing-symptoms-of-bronchial-obstruction
#16
Diamantis I Tsilimigras, Demetrios Moris, Ioannis Ntanasis-Stathopoulos, Davide Patrini, Nikolaos Panagiotopoulos
BACKGROUND: Bronchial carcinoid tumors (BCTs) are rare neuroendocrine neoplasms of the lung that mainly have a central distribution. They are classified as typical and atypical, with the former variant generally conferring a more favorable survival. Central tumors are usually symptomatic with features of bronchial obstruction, whereas peripheral tumors may remain silent. CASE REPORT: A 36-year-old woman presented to our hospital due to an episode of massive hemoptysis 5 days prior to admission...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882807/atlantic-salmon-endothelial-cells-from-the-heart-were-more-susceptible-than-fibroblasts-from-the-bulbus-arteriosus-to-four-rna-viruses-but-protected-from-two-viruses-by-dsrna-pretreatment
#17
Phuc H Pham, Winnie W L Tong, Ehab Misk, Ginny Jones, John S Lumsden, Niels C Bols
Heart diseases caused by viruses are major causes of Atlantic salmon aquaculture loss. Two Atlantic salmon cardiovascular cell lines, an endothelial cell line (ASHe) from the heart and a fibroblast cell line (BAASf) from the bulbus arteriosus, were evaluated for their response to four fish viruses, CSV, IPNV, VHSV IVa and VHSV IVb, and the innate immune agonist, double-stranded RNA mimic poly IC. All four viruses caused cytopathic effects in ASHe and BAASf. However, ASHe was more susceptible to all four viruses than BAASf...
September 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28882806/modulatory-effect-of-different-doses-of-%C3%AE-1-3-1-6-glucan-on-the-expression-of-antioxidant-inflammatory-stress-and-immune-related-genes-of-oreochromis-niloticus-challenged-with-streptococcus-iniae
#18
Abdallah S Salah, Abeer F El Nahas, Shawky Mahmoud
β-glucans are widely-known immunostimulants that are profusely used in aquaculture industry. The present study was conducted to evaluate the effect of different in-feed doses of β-1,3/1,6-glucans on the expression of antioxidant and stress-related genes (GST, HSP-70, Vtg), inflammation related genes (Il-8, TNFα, CXC-chemokine and CAS) and adaptive immune-related genes (MHC-IIβ, TLR-7, IgM-H, and Mx) of Oreochromis niloticus challenged and non-challenged with Streptococcus iniae. Six experimental groups were established: non-challenged control (non-supplemented diet), challenged control (non-supplemented diet), non-challenged supplemented with 0...
September 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28882802/identification-of-the-functional-regions-of-the-viral-haemorrhagic-septicaemia-virus-vhsv-nv-protein-variants-that-improve-function
#19
Blanca Chinchilla, Eduardo Gomez-Casado
Non-virion (NV) protein is essential for an efficient replication increasing the pathogenicity of the Salmonid novirhabdovirus (formerly IHNV), Piscine novirhabdovirus (formerly VHSV), and Hirame novirhabdovirus (HIRV). The interferon system, apoptosis, and other immune-related genes are modulated by NV to finally induce a deficient antiviral state in the cell. However, little is known about the VHSV NV regions involved in function and location. Here, eight different NV 07.71 fragments and eleven NV 07.71 mutants derived from the region between the two first α-helices have been studied in order to establish the mx and il8 transcript levels in ZF4 cells and the subcellular location...
September 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28878774/goose-mx-and-oasl-play-vital-roles-in-the-antiviral-effects-of-type-i-ii-and-iii-interferon-against-newly-emerging-avian-flavivirus
#20
Shun Chen, Wei Zhang, Zhen Wu, Jinyue Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying Wu, Xiaoyue Chen, Anchun Cheng
Duck Tembusu virus (TMUV), an emerging avian flavivirus, is highly pathogenic to birds and has the potential to become a zoonotic pathogen. Here, the molecular antiviral mechanism of goose type I, II, and III interferon (goIFNα, goIFNγ, and goIFNλ), the key components of the innate immune pathway, against TMUV was studied. We found that the transcription of goIFNs was obviously driven by TMUV infection in vivo and in vitro, and the titers and copies of TMUV were significantly reduced following treatment with goIFNs...
2017: Frontiers in Immunology
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