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https://www.readbyqxmd.com/read/29662898/comparing-different-recording-lengths-of-dynamic-cerebral-autoregulation-5-versus-10-minutes
#1
Nai-Fang Chi, Cheng-Yen Wang, Lung Chan, Han-Hwa Hu
We compared the dynamic cerebral autoregulation (dCA) indices between 5- and 10-minute data lengths by analyzing 37 patients with ischemic stroke and 51 controls in this study. Correlation coefficient ( Mx ) and transfer function analysis were applied for dCA analysis. Mx and phase shift in all frequency bands were not significantly different between 5- and 10-minute recordings [mean difference: Mx = 0.02; phase shift of very low frequency (0.02-0.07 Hz) = 0.3°, low frequency (0.07-0.20 Hz) = 0.6°, and high frequency (0...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29660689/quinonoid-compounds-via-reactions-of-lawsone-and-2-aminonaphthoquinone-with-%C3%AE-bromonitroalkenes-and-nitroallylic-acetates-structural-diversity-by-c-ring-modification-and-cytotoxic-evaluation-against-cancer-cells
#2
Thekke V Baiju, Renata G Almeida, Sudheesh T Sivanandan, Carlos A de Simone, Lucas M Brito, Bruno C Cavalcanti, Claudia Pessoa, Irishi N N Namboothiri, Eufrânio N da Silva Júnior
Morita-Baylis-Hillman acetates and α-bromonitroalkenes have been employed in cascade reactions with lawsone and 2-aminonaphthoquinone for the one-pot synthesis of heterocycle fused quinonoid compounds. The reactions reported here utilized the 1,3-binucleophilic potential of hydroxy- and aminonaphthoquinones and the 1,2/1,3-bielectrophilic potential of bromonitroalkenes and Morita-Baylis-Hillman acetates for the synthesis of pyrrole and furan fused naphthoquinones. The synthesized compounds were evaluated against HCT-116 (human colon carcinoma cells), PC3 (human prostate cancer cells), HL-60 (human promyelocytic leukemia cells), SF295 (human glioblastoma cells) and NCI-H460 (human lung cancer cells) and exhibited antitumor activity with IC50 values as low as < 2 μM...
April 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29660680/phase-composition-and-morphological-characterization-of-human-kidney-stones-using-ir-spectroscopy-scanning-electron-microscopy-and-x-ray-rietveld-analysis
#3
Paramita Chatterjee, Arup Chakraborty, Alok K Mukherjee
Pathological calcification in human urinary tract (kidney stones) is a common problem affecting an increasing number of people around the world. Analysis of such minerals or compounds is of fundamental importance for understanding their etiology and for the development of prophylactic measures. In the present study, structural characterization, phase quantification and morphological behaviour of thirty three (33) human kidney stones from eastern India have been carried out using IR spectroscopy (FT-IR), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM)...
April 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29652556/concordance-of-non-low-risk-disease-among-pairs-of-brothers-with-prostate-cancer
#4
Fredrik Jansson, Linda Drevin, Thomas Frisell, Pär Stattin, Ola Bratt, Olof Akre
Purpose Prostate cancer among first-degree relatives is a strong risk factor for diagnosis of prostate cancer, and the contribution of heritable factors in prostate cancer etiology is high. We investigated how the concordance of non-low-risk prostate cancer among brothers is affected by their genetic relation. Methods We identified 4,262 pairs of brothers with prostate cancer in the Prostate Cancer Database Sweden. Their cancers were categorized as low risk (Gleason score ≤ 6; clinical stage T1-2, Nx/N0, Mx/M0; and prostate-specific antigen ≤ 10 ng/mL) or non-low risk...
April 13, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29650477/determination-of-24-personal-care-products-in-fish-bile-using-hybrid-solvent-precipitation-and-dispersive-solid-phase-extraction-cleanup-with-ultrahigh-performance-liquid-chromatography-tandem-mass-spectrometry-and-gas-chromatography-mass-spectrometry
#5
Li Yao, Yin-Zhi Lv, Li-Juan Zhang, Wang-Rong Liu, Jian-Liang Zhao, You-Sheng Liu, Qian-Qian Zhang, Guang-Guo Ying
Personal care products (PCPs) are ubiquitous in aquatic environments owing to the continuous discharge of domestic wastewater from highly urbanized regions. These PCPs can be adsorbed by fish and thereafter usually enter the bile of the fish through biliary excretion. In this study, a sensitive method based on a combination of hybrid solvent precipitation and dispersive solid phase extraction (d-SPE) purification was developed to simultaneously extract and detect 24 PCPs, namely, 16 biocides, 4 synthetic musks, and 4 benzotriazoles, from fish bile...
April 5, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29648554/discovery-of-quinazoline-2-4-1h-3h-dione-derivatives-as-novel-parp-1-2-inhibitors-design-synthesis-and-their-antitumor-activity
#6
Jie Zhou, Ming Ji, Haiping Yao, Ran Cao, Hailong Zhao, Xiaoyu Wang, Xiaoguang Chen, Bailing Xu
Novel quinazoline-2,4(1H,3H)-dione derivatives bearing a 3-amino pyrrolidine moiety were designed and synthesized as PARP-1/2 inhibitors. Structure-activity relationships were examined which revealed a number of potent PARP-1/2 inhibitors with moderate selectivity toward PARP-1 over PARP-2. These compounds had IC50 values against PARP-1 at the 10-9 M level and against PARP-2 at the 10-8 M level. Among all the synthesized compounds, compounds 10 and 11 displayed strong cytotoxicities which are either used as a single agent or in combination with temozolomide (TMZ) in MX-1 cells (10, IC50 < 3...
April 12, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29628737/-in-vitro-study-of-white-spot-lesion-maxilla-and-mandibular-teeth
#7
Alizae Marny Mohamed, Kiong Hung Wong, Wan Jen Lee, Murshida Marizan Nor, Haizal Mohd Hussaini, Tanti Irawati Rosli
Aim: The aim of the study was to evaluate the effect of resin infiltration on colour changes and surface roughness of artificial white spot lesions (WSLs) on maxillary and mandibular premolar. Materials and methods: Sixty (60) extracted sound Maxilla (Mx) and Mandibular (Mn) premolars were randomly divided into 2 groups (test and control). Artificial WSLs were produced on buccal surface of teeth and were immersed in artificial saliva for 8 weeks. Colour components (L∗ , a∗ , b∗ ) and surface roughness (Sa∗ ) were assessed on 40 teeth using colour difference meter RD-100 and Alicona® Infinite Focus profilometer respectively...
April 2018: Saudi Dental Journal
https://www.readbyqxmd.com/read/29623598/accuracy-of-two-dimensional-pharyngeal-airway-space-prediction-for-bimaxillary-orthognathic-surgery
#8
Amanda Lury Yamashita, Lilian Cristina Vessoni Iwaki, Gustavo Nascimento de Souza Pinto, Bárbara Aline Gerke, Mariliani Chicarelli, Liogi Iwaki Filho
PURPOSE: The aim of this retrospective study was to evaluate the accuracy of two-dimensional (2D) virtual surgical planning (VSP) of pharyngeal airway space (PAS) in patients submitted to bimaxillary orthognathic surgery. METHODS: This study was conducted with lateral cephalograms acquired through cone-beam computed tomography records of 33 patients, divided into group 1-patients submitted to maxillary advancement and mandibular setback (n = 17) and group 2-patients submitted to maxillomandibular advancement (n = 16)...
April 5, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29619456/lithium-adsorption-and-migration-in-group-iv-vi-compounds-and-ges-graphene-heterostructures-a-comparative-study
#9
Kuan-Rong Hao, Lincan Fang, Qing-Bo Yan, Gang Su
By means of first-principles calculations, the adsorption and transport properties of lithium (Li) in orthorhombic group IV-VI compounds MX (M = Ge, Sn; X = S, Se) and GeS/graphene heterostructures have been systematically investigated. Strong interactions and distinct charge transfer between Li and compounds MX are observed. The Li diffusion barriers along the zigzag direction are found to be much lower than that along the armchair direction in monolayer and bulk MX, showing distinct anisotropic diffusion features...
April 5, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29608287/triphenylene-imidazolium-salts-and-their-nhc-metal-complexes-materials-with-segregated-multicolumnar-mesophases
#10
Ana B Miguel Coello, Manuel Bardají, Silverio Coco, Bertrand Donnio, Benoît Heinrich, Pablo Espinet
Two imidazolium salts containing one or two pentadodecyloxytriphenylene units linked through a hexyloxy chain and Br- , [AuBrm Cl4- m ]- , or [PtBrm Cl4- m ]2- ( m = 0-3) as counterion have been prepared. Reaction of the imidazolium bromides with M2 O (M = Cu, Ag), or carbene transmetalation from the silver product, leads to N-heterocyclic carbene complexes [MX(NHC)] (M = Cu, X = Br; M = Au, X = Cl, C≡CPh), [Ag(NHC)2 ][AgBr2 ], and [PtCl2 (NHC)2 ], with NHC bearing one or two triphenylene fragments. Except for the gold derivatives and one Cu complex, the rest of them behave as liquid crystals organized in columnar mesophases (rectangular c2 mm or p2mg or hexagonal p6mm symmetries) with melting points in the range 30 to 60 °C and clearing points in the range 57-112 °C...
April 2, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29608277/3d-synergistical-mxene-reduced-graphene-oxide-aerogel-for-a-piezoresistive-sensor
#11
Yanan Ma, Yang Yue, Hang Zhang, Feng Cheng, Wanqiu Zhao, Jiangyu Rao, Shijun Luo, Jie Wang, Xueliang Jiang, Zhitian Liu, Nishuang Liu, Yihua Gao
A piezoresistive sensor based on the ultralight and superelastic aerogel is reported to fabricate MXene/Reduced graphene oxide (MX/rGO) hybrid 3D structure and utilize their pressure-sensitive characteristics. The MX/rGO aerogel not only combines the rGO's large specific surface area and the MXene's (Ti3C2Tx) high conductivity but also exhibits rich porous structure, which leads to better performance than single component rGO or MXene in terms of the pressure sensor. And the large nanosheets of rGO can prevent the poor oxidization of MXene by wrapping MXene inside the aerogel...
April 2, 2018: ACS Nano
https://www.readbyqxmd.com/read/29605991/deriving-in-vivo-bioconcentration-factors-of-a-mixture-of-fragrance-ingredients-using-a-single-dietary-exposure-and-internal-benchmarking
#12
Chang-Er L Chen, Karin Löfstrand, Margaretha Adolfsson-Erici, Michael S McLachlan, Matthew MacLeod
Chemicals in mixtures that are hydrophobic with logKow > 4 are potentially bioaccumulative. Here, we evaluate an abbreviated and benchmarked in vivo BCF measurement methodology by exposing rainbow trout to a mixture of eight test chemicals found in fragrance substances and three benchmark chemicals (musk xylene (MX), hexachlorobenzene (HCB) and PCB52) via a single contaminated feeding event followed by a 28-day depuration period. Concentrations of HCB and PCB52 in fish did not decline significantly (their apparent depuration rate constants - kT were close to zero), while kT for MX was 0...
March 31, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29587792/major-contribution-of-the-rna-binding-domain-of-ns1-in-the-pathogenicity-and-replication-potential-of-an-avian-h7n1-influenza-virus-in-chickens
#13
Sascha Trapp, Denis Soubieux, Alexandra Lidove, Evelyne Esnault, Adrien Lion, Vanaique Guillory, Alan Wacquiez, Emmanuel Kut, Pascale Quéré, Thibaut Larcher, Mireille Ledevin, Virginie Nadan, Christelle Camus-Bouclainville, Daniel Marc
BACKGROUND: Non-structural protein NS1 of influenza A viruses harbours several determinants of pathogenicity and host-range. However it is still unclear to what extent each of its two structured domains (i.e. RNA-binding domain, RBD, and effector domain, ED) contribute to its various activities. METHODS: To evaluate the respective contributions of the two domains, we genetically engineered two variants of an H7N1 low pathogenicity avian influenza virus harbouring amino-acid substitutions that impair the functionality of either domain...
March 27, 2018: Virology Journal
https://www.readbyqxmd.com/read/29570417/reduction-of-marek-s-disease-virus-infection-by-toll-like-receptor-ligands-in-chicken-embryo-fibroblast-cells
#14
Jegarubee Bavananthasivam, Raveendra R Kulkarni, Leah Read, Shayan Sharif
Evolutionarily conserved pattern recognition receptors, including Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) that are present in microbes. PAMPs induce several pathways downstream of TLRs that lead to induction of antiviral responses. The objective of this study was to investigate the stimulatory effect of various PAMPs (in the form of TLR ligands) in reducing Marek's disease virus (MDV) infection in chicken embryo fibroblast cells (CEFs). To this end, CEFs were pretreated with Pam3CSK4, Poly(IC), lipopolysaccharide (LPS), and CpG ODN as TLR2, TLR3, TLR4, and TLR21 ligands, respectively for 24 h followed by infection with MDV...
March 23, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29569668/theranostic-micelles-based-on-upconversion-nanoparticles-for-dual-modality-imaging-and-photodynamic-therapy-in-hepatocellular-carcinoma
#15
Yong Han, Yanli An, Gang Jia, Xihui Wang, Chen He, Yinan Ding, Qiusha Tang
Hepatocellular carcinoma (HCC) is frequently metastatic once diagnosed and less likely to respond to curative surgery, emphasizing the need for the development of more sensitive and effective diagnostic and therapeutic strategies. Epithelial cell adhesion molecule (EpCAM) is deemed as the biomarker of cancer stem cells (CSCs), which are mainly responsible for the recurrence, metastasis and prognosis of HCC. In this study, we discuss the use of mitoxantrone (MX), an antitumor drug and a photosensitizer, for designing upconversion nanoparticle-based micelles grafted with the anti-EpCAM antibody, for dual-modality magnetic resonance/upconversion luminescence (MR/UCL)-guided synergetic chemotherapy and photodynamic therapy (PDT)...
March 23, 2018: Nanoscale
https://www.readbyqxmd.com/read/29567135/class-b-cpg-odn2006-is-highly-associated-with-igm-and-antimicrobial-peptide-gene-expression-through-tlr9-pathway-in-yellowtail-seriola-lalandi
#16
Carlos Angulo, Erika Alamillo, Ikuo Hirono, Hidehiro Kondo, Walissara Jirapongpairoj, Juan Carlos Perez-Urbiola, Martha Reyes-Becerril
The purpose of this study was to characterize the TLR9 gene from yellowtail (Seriola lalandi) and evaluate its functional activity using the class B Cytosine-phosphate-guanine-oligodeoxynucleotide2006 (CpG-ODN2006) in an in vivo experiment after one-week immunostimulation. The gene expressions of TLR9, Immunoglobulin M (IgM), antimicrobial peptides and cytokines were evaluated by real time PCR, and humoral immune parameters were analyzed in serum. The TLR9 nucleotide sequence from yellowtail was obtained using the whole-genome shotgun sequencing method and bioinformatics tools...
March 19, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29560117/hypoxic-marker-ca-ix-and-adhesion-mediator-%C3%AE-catenin-are-downregulated-by-lymphocytic-choriomeningitis-virus-persistent-infection
#17
Andrea Fabianova, Monika Barathova, Lucia Csaderova, Veronika Simko, Miriam Zatovicova, Martina Labudova, Jaromir Pastorek
Renal cell carcinoma is one of the most frequent cancer diseases with high resistance to radio- and chemotherapy. Mutation of VHL gene is frequent in these tumors leading to simulation of hypoxic conditions. Lymphocytic choriomeningitis virus, belonging to RNA viruses, is a neglected human pathogen and teratogen. We have found that infection of renal cell carcinoma cells by lymphocytic choriomeningitis virus strain MX causes a decrease of carbonic anhydrase IX protein and RNA level. Lower expression of carbonic anhydrase IX on the cell surface provides less target for carbonic anhydrase IX-targeted immunotherapy...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29559993/griffin-a-tool-for-symbolic-inference-of-synchronous-boolean-molecular-networks
#18
Stalin Muñoz, Miguel Carrillo, Eugenio Azpeitia, David A Rosenblueth
Boolean networks are important models of biochemical systems, located at the high end of the abstraction spectrum. A number of Boolean gene networks have been inferred following essentially the same method. Such a method first considers experimental data for a typically underdetermined "regulation" graph. Next, Boolean networks are inferred by using biological constraints to narrow the search space, such as a desired set of (fixed-point or cyclic) attractors. We describe Griffin , a computer tool enhancing this method...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29558779/management-of-anxiety-and-depressive-disorders-in-patients-%C3%A2-65-years-of-age-by-homeopath-general-practitioners-versus-conventional-general-practitioners-with-overview-of-the-epi3-laser-study-results
#19
Karine Danno, Gérard Duru, Jean Marie Vetel
BACKGROUND:  The increasing use of psychotropic drugs to treat anxiety and depressive disorders (ADDs) is concerning. According to the study, 'Etude Pharmacoépidémiologique de l'Impact de Santé Publique des modes de prise en charge pour 3 groupes de pathologies' (EPI3)-LASER, adult ADD patients who consult a general practitioner prescribing homeopathic medicines (GP-Ho) report less psychotropic drug use and are marginally more likely to experience clinical improvement than those receiving conventional care...
March 20, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29549940/magnetic-properties-and-cytocompatibility-of-transition-metal-incorporated-hydroxyapatite
#20
Michael E Zilm, Le Yu, William A Hines, Mei Wei
A detailed magnetization study, along with an assessment of the cellular proliferation, has been carried out on transition-metal-doped hydroxyapatite (HA), Ca10-x Mx (PO4 )6 (OH)2 , where M = Mn, Co, and Fe. In particular, a series of MnHA powder samples with an x value of 0.04 ≤ x ≤ 1.21, one CoHA (x = 0.48) and one FeHA sample (x = 1.06) were synthesized using a wet chemical method along with an ion-exchange procedure. Characterization by transmission electron microscope (TEM), energy-dispersive X-ray spectroscopy (EDXS), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) indicated that the substitution of M elements does not change the morphology and crystalline structure of pure HA that showing a single phased HA nano-rod...
June 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
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