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https://www.readbyqxmd.com/read/29236387/effect-of-3-substituted-1-4-benzodiazepin-2-ones-on-bradykinin-induced-smooth-muscle-contraction
#1
P A Virych, O V Shelyuk, T A Kabanova, E I Khalimova, V S Martynyuk, V I Pavlovsky, S A Andronati
Biochemical properties of 3-substituted 1,4-benzodiazepine determined by the characteristics of their chemical structure. Influence of 3-substituted 1,4-benzodiazepin-2-ones on maximal normalized rate and amplitudes of isometric smooth muscle contraction in rats was investigated. Compounds MX-1775 and MX-1828 demonstrated the similar inhibition effect on bradykinin-induced contraction of smooth muscle like competitive inhibitor des-arg9-bradykinin-acetate to bradykinin B2-receptors. MX-1626 demonstrated unidirectional changes of maximal normalized rate and force of smooth muscle that proportionally depended on bradykinin concentration in the range 10-10-10-6 M...
January 2017: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/29232133/alkali-metal-trihalides-m-x3-ion-pair-or-mx-x2-complex
#2
Zhi Sun, Kevin B Moore, J Grant Hill, Kirk A Peterson, Henry F Schaefer, Roald Hoffmann
The alkali metal trihalides MX3 (M = Li, Na, K, Rb, and Cs; X = Cl, Br, and I) are systematically studied using coupled-cluster methods. Benchmarks using CCSD(T) against diatomic experimental results suggest satisfactory performance for the weighted core-valence basis sets (new basis sets for K, Rb, and Cs) selected for predicting reliable structures and harmonic vibrational frequencies. An isomer search using the B3LYP functional yields a planar, yet asymmetric T-shaped Cs structure as the global minimum for all MX3 species...
December 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29224195/prevalence-of-soft-tissue-calcifications-in-the-maxillofacial-region-detected-by-cone-beam-ct
#3
Eucaé Miranda Missias, Eduarda Helena Leandro Nascimento, Maria Luiza Dos Anjos Pontual, Andréa Dos Anjos Pontual, Deborah Queiroz Freitas, Danyel Elias da Cruz Perez, Flávia Maria de Moraes Ramos-Perez
OBJECTIVE: To determine the prevalence of soft tissue calcifications in cone beam computed tomography (CBCT) scans with different fields of view (FOV), and to assess its relation with the clinical relevance of the CBCT findings. MATERIAL AND METHODS: One thousand CBCT scans were grouped according to FOV's size and region scanned (MX-FOV, maxilla; MD-FOV, mandible; and MM-FOV, maxilla/mandible) and evaluated for the presence of soft tissue calcifications. Laterality and length of the elongated styloid processes (ESP) were also assessed...
December 10, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29220462/first-steps-in-automatic-summarization-of-transcription-factor-properties-for-regulondb-classification-of-sentences-about-structural-domains-and-regulated-processes
#4
Carlos-Francisco Méndez-Cruz, Socorro Gama-Castro, Citlalli Mejía-Almonte, Marco-Polo Castillo-Villalba, Luis-José Muñiz-Rascado, Julio Collado-Vides
RegulonDB, http://regulondb.ccg.unam.mx.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29218581/fabrication-of-tip-dissolving-microneedles-for-transdermal-drug-delivery-of-meloxicam
#5
Jianmin Chen, Weiyue Huang, Ziyao Huang, Shiqi Liu, Yaling Ye, Qinglian Li, Meiping Huang
Dissolving microneedles (MNs) offered a simple, minimally invasive method for meloxicam (MX) delivery to the skin. However, the fabrication of dissolving MNs still faced some challenges, such as significant time consumption, loss of drug activity, and difficulty in regulating MN drug loading. To address these issues, we developed the tip-dissolving (TD) MNs. Several kinds of drugs were encapsulated successfully, and the quantity of MX ranged from 37.23 ± 8.40 to 332.53 ± 13.37 μg was precisely controlled...
December 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29210416/biexciton-and-trion-energy-transfer-from-cdse-cds-giant-nanocrystals-to-si-substrates
#6
Tianle Guo, Siddharth Sampat, Sara M Rupich, Jennifer A Hollingsworth, Matthew Buck, Han Htoon, Yves J Chabal, Yuri N Gartstein, Anton V Malko
Observation of energy transfer (ET) from multiexcitonic (MX) complexes in nanocrystal quantum dots (NQDs) has been severely restricted due to efficient nonradiative Auger recombination leading to very low MX emission quantum yields. Here we employed "giant" CdSe/CdS NQDs with suppressed Auger recombination to study ET of biexcitons (BX) and charged excitons (trions) into Si substrate. Photoluminescence (PL) measurements of (sub)monolayers of gNQDs controllably assembled on various interacting surfaces and augmented by single gNQD's imaging reveal appearance of BX spectral signatures and progressive acceleration of PL lifetimes of all excitonic species on Si substrates...
December 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/29207185/novel-multi%C3%A2-kinase-inhibitor-t03-inhibits-taxol%C3%A2-resistant-breast-cancer
#7
Yan Li, Chunxia Liu, Ke Tang, Yan Chen, Kang Tian, Zhiqiang Feng, Jindong Chen
Activation of kinase-associated signaling pathways is one of the leading causes of various malignant phenotypes in breast tumors. Strategies of drug discovery and development have investigated approaches to target the inhibition of protein kinase signaling. In the current study, the anti‑tumor activities of a novel multi‑kinase inhibitor, T03 were evaluated in breast cancer. T03 inhibited Taxol‑resistant breast cancer cell proliferation and induced cell cycle arrest and apoptosis in vitro and in vivo...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29199745/tuning-the-electronic-properties-of-bilayer-group-iv-monochalcogenides-by-stacking-order-strain-and-an-electric-field-a-computational-study
#8
Ze-Yu Li, Ming-Yang Liu, Yang Huang, Qing-Yuan Chen, Chao Cao, Yao He
As the isoelectronic counterpart of phosphorene, monolayer group IV-VI binary MX (M = Ge, Sn; X = Se, S) compounds have drawn considerable attention in recent years. In this paper, we construct four high-symmetry stacking models for bilayer MX to tune their electronic properties. We systematically explore the dynamical and thermal stabilities of all bilayer MX. It is found that five of them are possible at room temperature. Then, we perform first-principles calculations to study how the bilayer structure affects their electronic properties...
December 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29198037/gene-expression-profile-and-long-non-coding-rna-analysis-using-rna-seq-in-chicken-embryonic-fibroblast-cells-infected-by-avian-leukosis-virus-j
#9
Xuming Hu, Shihao Chen, Chongxin Jia, Songlei Xue, Chunfeng Dou, Zhenqing Dai, Hui Xu, Zhen Sun, Tuoyu Geng, Hengmi Cui
Avian leukosis virus J (ALVJ) infection induces hematopoietic malignancy in myeloid leukemia and hemangioma in chickens. However, little is known about the mechanisms underpinning the unique pathogenesis of ALVJ. In this study, we investigated the gene expression profiles of ALVJ-infected chicken cells and performed a comprehensive analysis of the long non-coding RNAs (lncRNAs) in CEF cells using RNA-Seq. As a result, 36 differentially expressed lncRNAs and 91 genes (FC > 2 and q-values < 0.05) were identified...
December 2, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29194973/perovskite-quantum-dots-and-their-application-in-light-emitting-diodes
#10
REVIEW
Hung-Chia Wang, Zhen Bao, Hsin-Yu Tsai, An-Cih Tang, Ru-Shi Liu
Perovskite quantum dots (PQDs) attract significant interest in recent years because of their unique optical properties, such as tunable wavelength, narrow emission, and high photoluminescence quantum efficiency (PLQY). Recent studies report new types of formamidinium (FA) PbBr3 PQDs, PQDs with organic-inorganic mixed cations, divalent cation doped colloidal CsPb1-x Mx Br3 PQDs (M = Sn2+ , Cd2+ , Zn2+ , Mn2+ ) featuring partial cation exchange, and heterovalent cation doped into PQDs (Bi3+ ). These PQD analogs open new possibilities for optoelectronic devices...
November 30, 2017: Small
https://www.readbyqxmd.com/read/29182517/the-electronic-and-optical-properties-of-the-sulvanite-compounds-a-many-body-perturbation-and-time-dependent-density-functional-theory-study
#11
William Fernando Espinosa, Santiago Perez-Walton, Jorge M Osorio-Guillén, Carlos Moyses Graca Araujo
We have studied by means of first-principles calculations the electronic and optical properties of the sulvanite family: Cu$_3$MX$_4$ (M = V, Nb, Ta and X = S, Se), that due to its broad range of gaps and chemical stability have emerged as promising materials for technological applications such as photovoltaics and transparent conductivity. To address the reliably of those properties we have used semi-local and hybrid functionals (PBEsol, HSE06), many-body perturbation theory (G$_0$W$_0$ approximation and Bethe-Salpeter equation), and time-dependent density functional theory (revised bootstrap kernel) to calculate the quasi-particle dispersion relation, band gaps, the imaginary part of the macroscopic dielectric function and the absorption coefficient...
November 28, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29172258/dual-function-of-gold-nanoparticles-in-synergism-with-mitoxantrone-and-microwave-hyperthermia-against-melanoma-cells
#12
Ahmad Shanei, Ameneh Sazgarnia, Elham Dolat, Leila Hojaji-Najafabadi, Mohammadreza Sehhati, Milad Baradaran-Ghahfarokhi
Background: This study was performed to evaluate any synergetic effects of mitoxantrone (MX) and gold nanoparticles (GNPs) as dual therapeutic approach, along with microwave (MW) hyperthermia for melanoma cancer. Methods: Various tests were performed on the DFW melanoma cell line in the presence of MX and different concentrations of GNPs, with and without MW irradiation. MTT [3-(4,5-dimethylthiazol–2-yl)-2,5-iphenyltetrazolium bromide] assays were conducted to evaluate the effectiveness of the used therapeutic methods in terms of cell survival...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29172175/a-predictive-threshold-value-for-the-diagnosis-of-early-pregnancy-in-cows-using-interferon-stimulated-genes-in-granulocytes
#13
Hitomi Yoshino, Noriyuki Toji, Kouya Sasaki, Katsuo Koshi, Norio Yamagishi, Toru Takahashi, Toshina Ishiguro-Oonuma, Hideo Matsuda, Tadayuki Yamanouchi, Yutaka Hashiyada, Kei Imai, Yoshiaki Izaike, Keiichiro Kizaki, Kazuyoshi Hashizume
Interferon tau plays an important role in establishing bovine pregnancy. Interferon-stimulated genes (ISGs) have been examined to identify a suitable indicator for the diagnosis of early gestation in cows. Although ISGs can be specifically detected in peripheral white blood cells during early gestation, its reliability remains to be validated. In the current study, a predictive threshold level of ISGs to determine pregnancy in cows during Days 20-22 of gestation was verified by analyzing the expression of ISGs in granulocytes and peripheral blood leucocytes (a total of 57 cows were used, 28 of which were pregnant and 29 were non-pregnant)...
November 16, 2017: Theriogenology
https://www.readbyqxmd.com/read/29161315/transcriptome-analysis-of-plasmid-induced-genes-sheds-light-on-the-role-of-type-i-ifn-as-adjuvant-in-dna-vaccine-against-infectious-salmon-anemia-virus
#14
Mehrdad Sobhkhez, Aleksej Krasnov, Chia Jung Chang, Børre Robertsen
A previous study showed that a plasmid expressing IFNa (pIFNa) strongly enhanced protection and antibody production of a DNA vaccine against infectious salmon anemia virus (ISAV) in Atlantic salmon. The vaccine consisted of a plasmid (pHE) expressing the virus hemagglutinin-esterase as an antigen. To increase the understanding of the adjuvant effect of pIFNa, we here compared transcriptome responses in salmon muscle at the injection site at week 1 and 2 after injection of pIFNa, pHE, plasmid control (pcDNA3...
2017: PloS One
https://www.readbyqxmd.com/read/29134199/rapid-directed-transport-of-dc-sign-clusters-in-the-plasma-membrane
#15
Ping Liu, Violetta Weinreb, Marc Ridilla, Laurie Betts, Pratik Patel, Aravinda M de Silva, Nancy L Thompson, Ken Jacobson
C-type lectins, including dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), are all-purpose pathogen receptors that exist in nanoclusters in plasma membranes of dendritic cells. A small fraction of these clusters, obvious from the videos, can undergo rapid, directed transport in the plane of the plasma membrane at average speeds of more than 1 μm/s in both dendritic cells and MX DC-SIGN murine fibroblasts ectopically expressing DC-SIGN. Surprisingly, instantaneous speeds can be considerably greater...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29120773/prediction-models-for-assessing-anthocyanins-in-grape-berries-by-fluorescence-sensors-dependence-on-cultivar-site-and-growing-season
#16
Patrizia Pinelli, Annalisa Romani, Elisa Fierini, Giovanni Agati
Fluorescence sensors are useful tools for the non-destructive assessment of grape berry anthocyanins. The Multiplex (Mx) sensor here studied provides two anthocyanin indices: ANTHR = log(1/Chl-fluorescence_R) and ANTHRG = log(Chl-fluorescence_R/Chl-fluorescence_G), based on the chlorophyll (Chl) fluorescence excited with red (R) and green (G) light. These indices were calibrated against wet chemistry. The dependence of anthocyanin prediction models on cultivar, season and site was studied on four cultivars in two Italian regions during three consecutive years...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29114209/the-biogenic-amine-tyramine-and-its-receptor-amtyr1-in-olfactory-neuropils-in-the-honey-bee-apis-mellifera-brain
#17
Irina T Sinakevitch, Sasha M Daskalova, Brian H Smith
This article describes the cellular sources for tyramine and the cellular targets of tyramine via the Tyramine Receptor 1 (AmTyr1) in the olfactory learning and memory neuropils of the honey bee brain. Clusters of approximately 160 tyramine immunoreactive neurons are the source of tyraminergic fibers with small varicosities in the optic lobes, antennal lobes, lateral protocerebrum, mushroom body (calyces and gamma lobes), tritocerebrum and subesophageal ganglion (SEG). Our tyramine mapping study shows that the primary sources of tyramine in the antennal lobe and calyx of the mushroom body are from at least two Ventral Unpaired Median neurons (VUMmd and VUMmx) with cell bodies in the SEG...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29109122/the-type-1-diabetes-resistance-locus-idd22-controls-trafficking-of-autoreactive-ctls-into-the-pancreatic-islets-of-nod-mice
#18
Robert L Whitener, Lisa Gallo Knight, Jianwei Li, Sarah Knapp, Shuyao Zhang, Mani Annamalai, Vadim M Pliner, Dongtao Fu, Ilian Radichev, Christina Amatya, Alexei Savinov, Arif Yurdagul, Shuai Yuan, John Glawe, Christopher G Kevil, Jing Chen, Scott E Stimpson, Clayton E Mathews
Type 1 diabetes (T1D) has a strong genetic component. The insulin dependent diabetes (Idd)22 locus was identified in crosses of T1D-susceptible NOD mice with the strongly T1D-resistant ALR strain. The NODcALR-(D8Mit293-D8Mit137)/Mx (NOD-Idd22) recombinant congenic mouse strain was generated in which NOD mice carry the full Idd22 confidence interval. NOD-Idd22 mice exhibit almost complete protection from spontaneous T1D and a significant reduction in insulitis. Our goal was to unravel the mode of Idd22-based protection using in vivo and in vitro models...
November 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29107428/pt-ii-pd-ii-and-au-iii-complexes-with-a-thiosemicarbazone-derived-from-diacethylmonooxime-structural-analysis-trypanocidal-activity-cytotoxicity-and-first-insight-into-the-antiparasitic-mechanism-of-action
#19
Ana C R Gonçalves, Zumira A Carneiro, Carolina G Oliveira, Amanda Danuello, Wendell Guerra, Ronaldo J Oliveira, Francis B Ferreira, Laudimir L W Veloso-Silva, Fernanda A H Batista, Júlio C Borges, Sérgio de Albuquerque, Victor M Deflon, Pedro I S Maia
New complexes of composition [MX(HL1)] (M = Pt(II), Pd(II), X = Cl(-) or I(-)) and [MX(L1)] (M = Au(III), X = Cl(-); M = Pt(II), Pd(II), X = PPh3) have been synthesized using a potentially tridentate thiosemicarbazone (H2L1) containing an additional oxime binding site. Among other analytical methods, all the seven complexes have been structurally characterized by single crystal X-ray diffractometry. Interesting structural features such as the influence of the halide ligands on hydrogen bonds and the formation of supramolecular structures for the phosphine derivatives are discussed...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29107065/efficacy-of-algal-ecklonia-cava-extract-against-viral-hemorrhagic-septicemia-virus-vhsv
#20
Han-Kook Yang, Myung-Hwa Jung, Satheesha Avunje, Chamilani Nikapitiya, So Young Kang, Young Bae Ryu, Woo Song Lee, Sung-Ju Jung
The inhibition efficacy of an extract from Ecklonia cava (E. cava) was studied to determine whether the extract and compounds exhibited inhibitory activity against VHSV in the fathead minnow (FHM) cell line and following oral administration to the olive flounder. Based on its low toxicity and effective concentration, the E. cava extract (Ext) and compounds (eckol and phlorofucofuroeckol A) were selected for further analysis. In the plaque reduction assay, simultaneous co-exposure of VHSV to Ext, eckol and phlorofucofuroeckol A showed a higher level of inhibition than the pre- and post-exposure groups...
November 9, 2017: Fish & Shellfish Immunology
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