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https://www.readbyqxmd.com/read/28201971/tio2-based-mitoxantrone-imprinted-poly-methacrylic-acid-co-polycaprolctone-diacrylate-nanoparticles-as-a-drug-delivery-system
#1
Maryam Bakhshizadeh, Ameneh Sazgarnia, Mahmoud Seifi, Farzin Hadizadeh, Ghadir Rajabzadeh, Seyed Ahmad Mohajeri
BACKGROUND: Light delivery in photodynamic therapy is a challenging issue in deep cancer treatment. To solve this problem, photosensitizers are conjugated to X-ray luminescent nanoparticles. When the complexes are stimulated by X-rays during radiotherapy, the nanoparticles generate light and activate the photosensitizers. METHODS: Core-shell molecularly imprinted polymers (MIPs) were prepared against mitoxantrone (MX) in which TiO2 nanoparticles were applied as a core, diacrylated polycaprolctone as a biodegradable cross-linker and methacrylic acid (MAA) or 4-vinylpyridin (4-VP) as the functional monomer...
February 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28196550/genetic-and-environmental-influences-on-last-year-major-depression-in-adulthood-a-highly-heritable-stable-liability-but-strong-environmental-effects-on-1-year-prevalence
#2
K S Kendler, C O Gardner
BACKGROUND: This study seeks to clarify the contribution of temporally stable and occasion-specific genetic and environmental influences on risk for major depression (MD). METHOD: Our sample was 2153 members of female-female twin pairs from the Virginia Twin Registry. We examined four personal interview waves conducted over an 8-year period with MD in the last year defined by DSM-IV criteria. We fitted a structural equation model to the data using classic Mx. The model included genetic and environmental risk factors for a latent, stable vulnerability to MD and for episodes in each of the four waves...
February 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28165204/strengthened-synergistic-effect-of-metallic-mx-py-m-co-ni-and-cu-and-carbon-layer-via-peapod-like-architecture-for-both-hydrogen-and-oxygen-evolution-reactions
#3
Yuanjuan Bai, Ling Fang, Haitao Xu, Xiao Gu, Huijuan Zhang, Yu Wang
The smooth electric transmission is crucial for the high-efficient electrocatalysis. Herein, a series of peapod-like metallic Mx Py /C (M = Co, Ni, and Cu) composites is developed as bifunctional catalysts toward hydrogen and oxygen evolution reactions. For the first time, the metallic property of Cu3 P is confirmed through the theoretical calculation. The in-depth composition, structural and catalytic mechanism analysis of Mx Py /C discloses that the comparable activity and considerable durability of these catalysts mainly result from the strengthened synergistic effect between metallic Mx Py and carbon layer based on the unique peapod-like architecture...
February 6, 2017: Small
https://www.readbyqxmd.com/read/28161961/genome-wide-gene-expression-pattern-underlying-differential-host-response-to-high-or-low-pathogenic-h5n1-avian-influenza-virus-in-ducks
#4
A Kumar, P Vijayakumar, P N Gandhale, P B Ranaware, H Kumar, D D Kulkarni, A A Raut, A Mishra
The differences in the influenza viral pathogenesis observed between different pathogenic strains are associated with distinct properties of virus strains and the host immune responses. In order to determine the differences in the duck immune response against two different pathogenic strains, we studied genome-wide host immune gene response of ducks infected with A/duck/India/02CA10/2011 and A/duck/Tripura/103597/2008 H5N1 viruses using custom-designed microarray. A/duck/India/02CA10/2011 is highly pathogenic virus (HP) to ducks, whereas A/duck/Tripura/103597/2008 is a low pathogenic (LP) virus strain...
February 6, 2017: Acta Virologica
https://www.readbyqxmd.com/read/28155014/molecular-xenomonitoring-mx-and-transmission-assessment-survey-tas-of-lymphatic-filariasis-elimination-in-two-villages-menoufyia-governorate-egypt
#5
M A Moustafa, M M I Salamah, H S Thabet, R A Tawfik, M M Mehrez, D M Hamdy
Lymphatic filariasis (LF) is focally endemic in Egypt where the female mosquito, Culex pipiens, is responsible for its transmission. The aim of the study was to investigate the impact of implementation of the 13th round of MDA in two Egyptian villages in the Menoufyia Governorate area after failing the transmission assessment survey (TAS) in 2005 using two methods, and to decide whether it is safe to stop MDA in these, as well as in similar implementation units (IUs). To achieve this aim, both the immunochromatographic card test (ICT) and molecular xenomonitoring (MX) techniques were employed...
February 2, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28149366/relationships-between-movements-of-the-lower-limb-joints-and-the-pelvis-in-open-and-closed-kinematic-chains-during-a-gait-cycle
#6
Zdenek Svoboda, Miroslav Janura, Patrik Kutilek, Eva Janurova
Lots of athletic skills performed during practice or competition are initiated by the legs, where athletes either walk or run prior to executing specific skills. Kinematic chains are used to describe the relationships between body segments and joints during movement. The aim of this study was to determine the relationships between movements of lower limb segments and the pelvis in open and closed kinematic chains while walking. The experimental group consisted of 32 males (age 23.3 ± 2.5 years, body mass 78...
June 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28137651/immune-gene-profiles-in-atlantic-salmon-salmo-salar-l-post-smolts-infected-with-sav3-by-bath-challenge-show-a-delayed-response-and-lower-levels-of-gene-transcription-compared-to-injected-fish
#7
L J Moore, J Jarungsriapisit, T O Nilsen, S Stefansson, G L Taranger, C J Secombes, H C Morton, S Patel
Salmonid alphavirus (SAV) causes pancreatic disease (PD) in salmonids in Northern Europe which results in large economic losses within the aquaculture industry. In order to better understand the underlying immune mechanisms during a SAV3 infection Atlantic salmon post-smolts were infected by either i.m.-injection or bath immersion and their immune responses compared. Analysis of viral loads showed that by 14 dpi i.m.-injected and bath immersion groups had 95.6% and 100% prevalence respectively and that both groups had developed the severe pathology typical of PD...
January 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28135069/quasi-epitaxial-metal-halide-perovskite-ligand-shells-on-pbs-nanocrystals
#8
Mykhailo Sytnyk, Sergii Yakunin, Wolfgang Schöfberger, Rainer T Lechner, Max Burian, Lukas Ludescher, Niall A Killilea, AmirAbbas YousefiAmin, Dominik Kriegner, Julian Stangl, Heiko Groiss, Wolfgang Heiss
Epitaxial growth techniques enable nearly defect free heterostructures with coherent interfaces, which are of utmost importance for high performance electronic devices. While high-vacuum technology-based growth techniques are state-of-the art, here we pursue a purely solution processed approach to obtain nanocrystals with eptaxially coherent and quasi-lattice matched inorganic ligand shells. Octahedral metal-halide clusters, respectively 0-dimensional perovskites, were employed as ligands to match the coordination geometry of the PbS cubic rock-salt lattice...
February 1, 2017: ACS Nano
https://www.readbyqxmd.com/read/28120734/association-between-dietary-fat-intake-and-insulin-resistance-in-chinese-child-twins
#9
Tao Huang, Terri Beaty, Ji Li, Huijuan Liu, Wei Zhao, Youfa Wang
Dietary fat intake is correlated with increased insulin resistance (IR). However, it is unknown whether gene-diet interaction modulates the association. This study estimated heritability of IR measures and the related genetic correlations with fat intake, and tested whether dietary fat intake modifies the genetic influence on type 2 diabetes (T2D)-related traits in Chinese child twins. We included 622 twins aged 7-15 years (n 311 pairs, 162 monozygotic (MZ), 149 dizygotic (DZ)) from south-eastern China. Dietary factors were measured using FFQ...
January 25, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28119145/sexual-maturation-in-atlantic-salmon-induces-a-constitutive-mx-protein-production-and-influences-the-infectious-pancreatic-necrosis-virus-carrier-status
#10
M C S Fourrier, M M Monte, E S Munro
The aim of this study was to demonstrate for the first time that sexual maturation induces a constitutive increase in Mx gene expression and protein production in Atlantic salmon. This could explain the reduction in IPNV prevalence previously observed in broodfish at the time of ova/milt stripping. For this purpose, Mx transcript and protein levels were analysed in different tissues/samples and compared between mature broodfish (female and male) and immature parr.
January 22, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28108227/cerebral-blood-flow-autoregulation-is-impaired-in-schizophrenia-a-pilot-study
#11
Hsiao-Lun Ku, Jiunn-Kae Wang, Hsin-Chien Lee, Timothy Joseph Lane, I-Chao Liu, Yung-Chan Chen, Yao-Tung Lee, I-Cheng Lin, Chia-Pei Lin, Chaur-Jong Hu, Nai-Fang Chi
Patients with schizophrenia have a higher risk of cardiovascular diseases and higher mortality from them than does the general population; however, the underlying mechanism remains unclear. Impaired cerebral autoregulation is associated with cerebrovascular diseases and their mortality. Increased or decreased cerebral blood flow in different brain regions has been reported in patients with schizophrenia, which implies impaired cerebral autoregulation. This study investigated the cerebral autoregulation in 21 patients with schizophrenia and 23 age- and sex-matched healthy controls...
January 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28107935/tetraphasic-polar-organic-chemical-integrative-sampler-for-the-determination-of-a-wide-polarity-range-organic-pollutants-in-water-the-use-of-performance-reference-compounds-and-in-situ-calibration
#12
A Iparraguirre, A Prieto, A Vallejo, M Moeder, O Zuloaga, N Etxebarria, A Paschke
In the present work, a homemade polar organic chemical integrative sampler (POCIS) was studied for the determination of 16 target analytes. The suitability of the combination of triphasic mixture (used in so called pesticides-POCIS) and octadecyl-functionalized silica gel (C18) as sorbent for POCIS was evaluated for the determination of alkylphenols (APs), several hormones, bisphenol-A (BPA), synthetic musk fragrances and herbicides such as trifluralin (Tri) and alachlor (Ala). With this purpose, POCIS laboratory calibration study, using a continuous-flow calibration system, was carried out in order to determine the uptake behavior and sampling rate (Rs) values for each target analyte...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28105747/virulence-and-genotypes-of-white-spot-syndrome-virus-infecting-pacific-white-shrimp-litopenaeus-vannamei-in-north-western-mexico
#13
J Ramos-Paredes, J M Grijalva-Chon, J C Ibarra-Gámez
White spot syndrome virus (WSSV) has caused substantial global economic impact on aquaculture, and it has been determined that strains can vary in virulence. In this study, the effect of viral load was evaluated by infecting Litopenaeus vannamei with 10-fold serial dilution of tissue infected with strain WSSV Mx-H, and the virulence of four WSSV strains from north-western Mexico was assessed along with their variable number of tandem repeat (VNTR) genotypes in ORF75, ORF94 and ORF125. The LD50 of the Mx-H strain was a dilution dose of 10(-7...
March 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28099160/phase-shift-between-respiratory-oscillations-in-cerebral-blood-flow-velocity-and-arterial-blood-pressure
#14
Agnieszka Uryga, Michał M Placek, Paweł Wachel, Tomasz Szczepański, Marek Czosnyka, Magdalena Kasprowicz
We aim to investigate whether phase shift between respiratory oscillations in cerebral blood flow velocity (CBFV) and arterial blood pressure (ABP) is associated with changes in cerebral autoregulation (CA) or reflects the mechano-elastic properties of the cerebrovascular bed. The relationships between respiratory phase shift and slow wave phase shift versus cerebrovascular time constant (the product of cerebrovascular resistance and compliance) and the index of CA (Mx) were analyzed during breathing at 6, 10, and 15 breaths min(-1) in 39 volunteers...
January 18, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28098816/estrogen-enhances-the-expression-of-the-multidrug-transporter-gene-abcg2-increasing-drug-resistance-of-breast-cancer-cells-through-estrogen-receptors
#15
Fung-Wei Chang, Hueng-Chuen Fan, Jui-Ming Liu, Tai-Ping Fan, Jin Jing, Chia-Ling Yang, Ren-Jun Hsu
BACKGROUND: Multidrug resistance is a major obstacle in the successful therapy of breast cancer. Studies have proved that this kind of drug resistance happens in both human cancers and cultured cancer cell lines. Understanding the molecular mechanisms of drug resistance is important for the reasonable design and use of new treatment strategies to effectively confront cancers. RESULTS: In our study, ATP-binding cassette sub-family G member 2 (ABCG2), adenosine triphosphate (ATP) synthase and cytochrome c oxidase subunit VIc (COX6C) were over-expressed more in the MCF-7/MX cell line than in the normal MCF7 cell line...
January 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28075421/mx-is-not-responsible-for-the-antiviral-activity-of-interferon-%C3%AE-against-japanese-encephalitis-virus
#16
Jing Zhou, Shi-Qi Wang, Jian-Chao Wei, Xiao-Min Zhang, Zhi-Can Gao, Ke Liu, Zhi-Yong Ma, Pu-Yan Chen, Bin Zhou
Mx proteins are interferon (IFN)-induced dynamin-like GTPases that are present in all vertebrates and inhibit the replication of myriad viruses. However, the role Mx proteins play in IFN-mediated suppression of Japanese encephalitis virus (JEV) infection is unknown. In this study, we set out to investigate the effects of Mx1 and Mx2 expression on the interferon-α (IFNα) restriction of JEV replication. To evaluate whether the inhibitory activity of IFNα on JEV is dependent on Mx1 or Mx2, we knocked down Mx1 or Mx2 with siRNA in IFNα-treated PK-15 cells and BHK-21 cells, then challenged them with JEV; the production of progeny virus was assessed by plaque assay, RT-qPCR, and Western blotting...
January 10, 2017: Viruses
https://www.readbyqxmd.com/read/28062005/gga-mir-2127-downregulates-the-translation-of-chicken-p53-and-attenuates-chp53-mediated-innate-immune-response-against-ibdv-infection
#17
Wei Ouyang, Yong-Shan Wang, Kai Meng, Qun-Xing Pan, Xiao-Li Wang, Xing-Xia Xia, Yu-Mei Zhu, Zhen-Wei Bi, Hai-Bin Zhang, Kai Luo
Infectious bursal disease (IBD) is characterized by the immune suppression of infected birds. The molecular mechanism by which IBD virus (IBDV) suppresses the host immune system remains to be elucidated. The tumor suppressor protein p53 can inhibit the replication of various viruses, but its effect on IBDV remains unknown. This study established an in vitro infection model based on DF-1 cells (chicken embryo fibroblast cell line) to investigate the antiviral effects of chicken p53 (chp53) on IBDV infection...
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28049325/indirect-nmr-spin-spin-coupling-constants-in-diatomic-alkali-halides
#18
Michał Jaszuński, Andrej Antušek, Taye B Demissie, Stanislav Komorovsky, Michal Repisky, Kenneth Ruud
We report the Nuclear Magnetic Resonance (NMR) spin-spin coupling constants for diatomic alkali halides MX, where M = Li, Na, K, Rb, or Cs and X = F, Cl, Br, or I. The coupling constants are determined by supplementing the non-relativistic coupled-cluster singles-and-doubles (CCSD) values with relativistic corrections evaluated at the four-component density-functional theory (DFT) level. These corrections are calculated as the differences between relativistic and non-relativistic values determined using the PBE0 functional with 50% exact-exchange admixture...
December 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28032357/in-vivo-study-of-viral-haemorrhagic-septicaemia-virus-and-infectious-pancreatic-necrosis-virus-coexistence-in-senegalese-sole-solea-senegalensis
#19
C López-Vázquez, M C Alonso, C P Dopazo, I Bandín
The effect of IPNV-VHSV coinfection and superinfection on the mortality caused by both viruses in Senegalese sole has been analysed. No effect was observed after coinfection. However, a clear viral interference was recorded between a primary IPNV and a subsequent VHSV infection, which led to a survival increase in the infected sole of 50% points when compared with fish infected only with VHSV. The significantly higher Mx transcriptional values in the fish pre-exposed to IPNV (at least at first days after superinfection) and the increased daily mortality when low Mx transcriptional levels were recorded suggest that Mx may be involved in the protective effect against VHSV infection...
December 29, 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28027847/improvement-influenza-ha2-dna-vaccine-cellular-and-humoral-immune-responses-with-mx-bio-adjuvant
#20
Sina Soleimani, Shahla Shahsavandi, Omid Maddadgar
Immunization with DNA vaccines as a novel alternative to conventional vaccination strategy requires adjuvant for improving vaccine efficacy. The conserved immunogenic HA2 subunit, which harbors neutralizing epitopes is a promising vaccine candidate against influenza viruses. In this study, for the first time we explore the idea of using host interferon inducible Mx protein to increase the immunogenicity of HA2 H9N2 influenza DNA vaccine. The potency and safety of the Mx adjuvanted-HA2 vaccine was evaluated in BALB/c mice by different prime-boost strategies...
December 24, 2016: Biologicals: Journal of the International Association of Biological Standardization
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