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Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
Summary: Operon-mapper is a web server that accurately, easily, and directly predicts the operons of any bacterial or archaeal genome sequence. The operon predictions are based on the intergenic distance of neighboring genes as well as the functional relationships of their protein-coding products. To this end, Operon-mapper finds all the ORFs within a given nucleotide sequence, along with their genomic coordinates, orthology groups, and functional relationships. We believe that Operon-mapper, due to its accuracy, simplicity and speed, as well as the relevant information that it generates, will be a useful tool for annotating and characterizing genomic sequences...
June 19, 2018: Bioinformatics
Bin Xu, Qinghua Pan, Chen Liang
Type I interferon inhibits viruses through inducing the expression of antiviral proteins, including the myxovirus resistance (Mx) proteins. Compared to human MxA protein that inhibits a wide range of viruses, the MxB protein has been reported to specifically inhibit primate lentiviruses including HIV-1, and herpesviruses. Further, the role of endogenous MxB in interferon-α mediated inhibition of HIV-1 infection was questioned by a recent study showing that MxB knockout did not increase the infection of HIV-1 which carried the G protein of vesicular stomatitis virus (VSV), and thus was able to infect CD4-negative HT1080 cells...
June 20, 2018: Journal of Virology
Aude Paquet, Bertrand Olliac, Bernard Golse, Laurence Vaivre-Douret
INTRODUCTION: Several authors have suggested the existence of motor disorders associated with developmental coordination disorder (DCD) in individuals with autism spectrum disorder (ASD). However, there are few comparative studies of psychomotor profiles that include assessments of neurological soft signs in children with ASD or DCD. We used a neuropsychomotor assessment for children with ASD from a standardized neurodevelopmental examination to understand the nature of the difficulties these children encounter...
June 20, 2018: Journal of Clinical and Experimental Neuropsychology
Siti Nur Ezzati Yazid, Hemashangari Thanggavelu, Norlia Mahror, Jinap Selamat, Nik Iskandar Putra Samsudin
In studying the ecophysiology of fungal phytopathogens, several stages are involved (in vitro, greenhouse, in planta). Most in vitro studies extensively utilise the general growth media such as Potato Dextrose Agar and Malt Extract Agar. Although the crop components in these media serve as excellent carbon sources and yield luxuriant growth, they are not naturally contaminated with Aspergillus flavus and thus might result in under- or overestimation of its actual toxigenic potentials. Empirical data on the formulation of semi-synthetic growth medium mimicking the natural crop commonly contaminated by A...
June 9, 2018: International Journal of Food Microbiology
Anu S Helin, Michelle Wille, Clara Atterby, Josef Järhult, Jonas Waldenström, Joanne R Chapman
This article provides data on primer sequences used to amplify the innate immune genes RIG-I and Mx and a set of normalizing reference genes in mallards ( Anas platyrhynchos ), and shows which reference genes are stable, per tissue, for our experimental settings. Data on the expressional changes of these two genes over a time-course of infection with low pathogenic avian influenza virus (LPAI) are provided. Individual-level data are also presented, including LPAI infection load, and per tissue gene expression of RIG-I and Mx ...
June 2018: Data in Brief
Zhiyun Zhang, Chi-Lin Chen, Yi-An Chen, Yu-Chen Wei, Jianhua Su, He Tian, Pi-Tai Chou
ortho-Methyl effects are exploited to tune steric hindrance between side-chain N,N´-diaryls and polycyclic dihydrodibenzo[a,c]phenazine, and in turn control the conformations of N,N´-diphenyl-dihydrodibenzo[a,c]phenazine (DPAC) and its ortho-methyl(s) derivatives Mx-My (x = 0, 1 or 2, y = 1 or 2, x and y correlate with the number of methyl groups in the ortho-sites of N,N´-diphenyl). The magnitude of steric hindrance increases as x and y increase, and the V-shaped dihydrodibenzo[a,c]phenazine skeleton is gradually tuned from bent (DPAC) to planar (M2-M2) structure in the ground state...
June 13, 2018: Angewandte Chemie
Violeta T Pardío, Argel Flores, Karla M López, David I Martínez, Ofelia Márquez, Krzysztof N Waliszewski
Endogenous and exogenous enzymatic hydrolysis carried out to obtain vanilla extracts with higher concentrations of vanillin using green vanilla beans. Sequences initiated with freezing of green vanilla beans at - 1 °C for 24 h, followed by endogenous hydrolysis under optimal β-glucosidase activity at 4.2 and 35 °C for 96 h, exogenous hydrolysis with Crystalzyme PML-MX at pH 5.0 and 40 °C for 72 h, and ethanol extraction at 40% (v v-1 ) for 30 days. In the proposed method, 200 g of fresh green vanilla beans with 84% moisture (32 g dry base) were used to obtain a liter of single fold vanilla extract...
June 2018: Journal of Food Science and Technology
Rui Jiang, Chunming Zhao, Binbin Gao, Jiawen Xu, Wei Song, Peng Shi
OBJECTIVE: This study aimed at finding the long non-coding RNA (lncRNA), miRNA and mRNA which played critical roles in breast cancer (BrCa) by using mixOmics R package. METHOD: The BrCa dataset were obtained from TCGA and then analyzed using "DESeq2" R package. Multivariate analyses were performed with the "mixOmics" R package and the first component of the stacked partial least-Squares discriminant analysis results were used for searching the interested lncRNA, miRNA and mRNA...
June 8, 2018: International Journal of Biochemistry & Cell Biology
Shun Chen, Tao Wang, Peng Liu, Chao Yang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Anchun Cheng
Human interferon regulatory factor 7 (IRF7) plays an important role in the innate antiviral immune response. To date, the characteristics and functions of waterfowl IRF7 have not been clarified. This study reports the cDNA sequence, tissue distribution, and antiviral function of duck IRF7. The duck IRF7 gene has a 1536-bp open read frame (ORF) and encodes a 511-amino acid polypeptide. IRF7 is highly expressed in the blood and pancreas of 5-day-old ducklings and in the small intestine, large intestine and liver of 60-day-old adult ducks...
June 6, 2018: Cytokine
L Tondo, G H Vázquez, M Pinna, P A Vaccotto, R J Baldessarini
OBJECTIVE: To assess differences between subjects with vs. without mixed features in major affective disorders. METHODS: In 3099 out-patient subjects with DSM-5 major depressive disorder (MDD, n = 1921) or bipolar disorders (BD, n = 1178), we compared those with (Mx) vs. without (Non-Mx) mixed features (agitated-irritable depression or dysphoric [hypo]mania) in an index episode. RESULTS: Prevalence of Mx averaged 21.9% [CI: 20.5-23.4] overall, ranking: BD-II > BD-I > MDD, and in BD depression ≥ [hypo]mania > MDD...
June 3, 2018: Acta Psychiatrica Scandinavica
Changsheng Song, Wen Xiao, Ping Lin, Jingjing Wang, Jiaqi Pan, Can Cui, Chaorong Li, Jiqing Wang
By using first-principles calculations, we demonstrate the influence of proximity effect on the band structures of heterostructures formed by graphene stacking on a two dimensional (2D) topological insulator (TI) 1T'-MX2. The interlayer distance d between graphene and TI decreases with the enhancement of the intrinsic lattice anisotropy of 1T'-MX2, which determines different strength of the interlayer proximity interaction. The bandgap can be opened by the proximity exchange. The weak anisotropic symmetry of heterostructure (large d) only results in a small band gap (∼ 50 meV) in graphene/MoTe2...
May 25, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Xingshuai Lv, Wei Wei, Hongchao Yang, Jinjin Li, Baibiao Huang, Ying Dai
Although the rechargeable lithium-sulfur batteries are considered as an advanced energy system, its practical implementation is impeded by many factors, in particular the rapid capacity fade and low Coulomb efficiency caused by the shuttle effect. To overcome this problem for achieving longer cycle life and higher rate performance, anchoring materials for the lithium polysulfides are highly desirable. In this work, for the first time, we report phosphorene-like MX (M=Ge, Sn; X=S, Se) monolayers as promising anchoring materials to restrain the lithium polysulfides shuttling...
May 24, 2018: Chemistry: a European Journal
Takaaki Oba, Ken-Ichi Ito
Improved prognosis for triple-negative breast cancer (TNBC) has currently plateaued and the development of novel therapeutic strategies is required. Therefore, we aimed to explore the anti-tumor effect of eribulin and paclitaxel combination therapy for TNBC. The effect of eribulin and paclitaxel in combination was tested, with both concurrent and sequential administration, using four TNBC cell lines (MDA-MB-231, Hs578T, MDA-MB-157, and Mx-1) in vitro and in an MDA-MB-231 BALB/c-nu/nu mouse xenograft model. The expression of epithelial-mesenchymal phenotypic markers was analyzed by western blotting and immunohistochemical analyses...
May 1, 2018: Oncotarget
Krista M Beach, Li-Fang Hung, Baskar Arumugam, Earl L Smith, Lisa A Ostrin
Adenosine receptor (ADOR) antagonists, such as 7-methylxanthine (7-MX), have been shown to slow myopia progression in humans and animal models. Adenosine receptors are found throughout the body, and regulate the release of neurotransmitters such as dopamine and glutamate. However, the role of adenosine in eye growth is unclear. Evidence suggests that 7-MX increases scleral collagen fibril diameter, hence preventing axial elongation. This study used immunohistochemistry (IHC) and reverse-transcription quantitative polymerase chain reaction (RT-qPCR) to examine the distribution of the four ADORs in the normal monkey eye to help elucidate potential mechanisms of action...
May 21, 2018: Experimental Eye Research
Shu Wu, Jinpiao Lin, Ya Fu, Qishui Ou
BACKGROUND: IFN-α is widely used for the treatment of chronic hepatitis B (CHB) infection due to its high HBsAg loss. However, IFN-α treatment has a number of side effects. Thus, identification of molecular biomarkers to predict IFN-α therapeutic effect would be useful in the clinic. In this study, we aim to study the role of RIG-I in prediction of IFN-α curative effect of CHB patients. METHODS: A total of 65 CHB patients treated with PegIFN-αweekly for 48 weeks were enrolled...
May 23, 2018: Antiviral Therapy
C Dirks, D Grünewald, P Young, A Heidbreder
BACKGROUND: Sleep disorders are associated with serious health problems in blind and visually impaired persons. Loss of light perception may result in a shift of sleep-wake pattern, which may lead to significant impairments in daily life--the so-called non-24-hour sleep-wake disorder. To date, epidemiologic data on non-24 only exist for the USA. This pilot study was conducted to provide first epidemiologic data for the prevalence of non-24 and other sleep disorders among blind and visually impaired persons in Germany...
May 22, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Yang Wu, Li Wang, Tiantian Guo, Yanping Jiang, Xinyuan Qiao, Li Sun, Min Liu, Lijie Tang, Yigang Xu, Yijing Li
Our previous studies demonstrated that the nonstructural NV protein of infectious hematopoietic necrosis virus (IHNV) was essential for efficient viral replication and pathogenicity, and that the amino acid residues 32 EGDL35 of the NV protein were responsible for nuclear localization, and played important roles in suppressing IFN and inhibiting NF-κB activity. However, little is known about the influence of 32 EGDL35 on IHNV replication and pathogenicity. In the present study, two recombinant IHNV strains with deletions of NV 32 EGDL35 were generated and the effect on IHNV replication and pathogenicity was explored...
May 18, 2018: Fish & Shellfish Immunology
Xiao-Yi Liu, Eunson Hwang, Bom Park, Hien T T Ngo, Yong-Kun Xiao, Tae-Hoo Yi
Notoginseng is a traditional herbal medicine widely used for medicinal therapy in Asia, as it contains numerous ginsenosides with pharmacological effects. In this study, we submitted Notoginseng stem-leaf (NGL) ginsenosides to an enzyme to create reaction the monomer products of ginsenoside C-Mx and then investigated the ability of ginsenoside C-Mx to protect the skin against ultraviolet B-induced injury in normal human dermal fibroblasts (NHDFs). Ginsenoside C-Mx alleviated UVB-induced intracellular reactive oxygen species (ROS), MMP-1, and IL-6 expression while accelerating TGF-β and procollagen type I secretion...
May 20, 2018: Photochemistry and Photobiology
Hongyun Li, Chengyue Jiang, Dong Cui, Shuang Lu
Background: Occupant injuries in rollover crashes are associated with vehicle structural performance, as well as the restraint system design. For a better understanding of the occupant kinematics and injury index in certain rollover crash, it is essential to carry out dynamic vehicle rollover simulation with dummy included. Objective: This study focused on effects of curtain airbag (CAB) parameters on occupant kinematics and injury indexes in a rollover crash. Besides, optimized parameters of the CAB were proposed for the purpose of decreasing the occupant injuries in such rollover scenario...
2018: Applied Bionics and Biomechanics
Yulema Valero, Mokrani Djamal, Elena Chaves-Pozo, Marta Arizcun, Mustapha Oumouna, José Meseguer, M Ángeles Esteban, Alberto Cuesta
Developing viral vaccines through the ultraviolet (UV) inactivation of virus is promising technique since it is straightforward and economically affordable, while the resulting viruses are capable of eliciting an adequate antiviral immune response. Nodavirus (NNV) is a devastating virus that mainly affects European sea bass juveniles and larvae, causing serious economic losses in Mediterranean aquaculture. In this work, a potential vaccine consisting on UV-inactivated NNV (iNNV) was generated and administered to healthy juveniles of European sea bass to elucidate whether it triggers the immune response and improves their survival upon challenge...
May 11, 2018: Developmental and Comparative Immunology
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