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tolergenic dc

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https://www.readbyqxmd.com/read/18549444/induction-of-il-10-producing-cd4-t-cells-with-regulatory-activities-by-stimulation-with-il-10-gene-modified-bone-marrow-derived-dendritic-cells
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C-L Fu, Y-H Chuang, H-Y Huang, B-L Chiang
Dendritic cells (DCs) can induce both tolergenic as well as effective immune responses in the lung. Pulmonary DCs producing interleukin (IL)-10 mediated tolerance induced by respiratory exposure to antigen. IL-10 is an important immunosuppressive cytokine, which inhibits maturation and function of DC. To assess whether IL-10 producing DCs can exert the tolergenic effect through the differentiation of regulatory T cells, bone marrow derived DCs were genetically modified by IL-10 expressing adenovirus. IL-10 gene modified DCs (Ad-IL-10-DC) displayed a characteristic phenotype of immature DCs...
August 2008: Clinical and Experimental Immunology
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