Thanh-Hau Huynh, Hee Kyung Kim, Jayho Lee, Yeon Hee Ban, Yong-Joon Jang, Bo Eun Heo, Thanh Quang Nguyen, Joon Soo An, Yun Kwon, Sang-Jip Nam, Jichan Jang, Ki-Bong Oh, Min-Kyoo Shin, Dong-Chan Oh
A new polyol polyketide, named retinestatin ( 1 ), was obtained and characterized from the culture of a Streptomyces strain, which was isolated from a subterranean nest of the termite Reticulitermes speratus kyushuensis Morimoto. The planar structure of 1 was elucidated on the basis of the cumulative analysis of ultraviolet, infrared, mass spectrometry, and nuclear magnetic resonance spectroscopic data. The absolute configuration of 1 at 12 chiral centers was successfully assigned by employing a J -based configuration analysis in combination with ROESY correlations, a quantum mechanics-based computational approach to calculate NMR chemical shifts, and a 3 min flash esterification by Mosher's reagents followed by NMR analysis...
March 5, 2024: Journal of Natural Products