keyword
https://read.qxmd.com/read/38449738/mito-metformin-protects-against-mitochondrial-dysfunction-and-dopaminergic-neuronal-degeneration-by-activating-upstream-pkd1-signaling-in-cell-culture-and-mitopark-animal-models-of-parkinson-s-disease
#21
JOURNAL ARTICLE
Muhammet Ay, Adhithiya Charli, Monica Langley, Ahyoung Jang, Piyush Padhi, Huajun Jin, Vellareddy Anantharam, Balaraman Kalyanaraman, Arthi Kanthasamy, Anumantha G Kanthasamy
Impaired mitochondrial function and biogenesis have strongly been implicated in the pathogenesis of Parkinson's disease (PD). Thus, identifying the key signaling mechanisms regulating mitochondrial biogenesis is crucial to developing new treatment strategies for PD. We previously reported that protein kinase D1 (PKD1) activation protects against neuronal cell death in PD models by regulating mitochondrial biogenesis. To further harness the translational drug discovery potential of targeting PKD1-mediated neuroprotective signaling, we synthesized mito-metformin (Mito-Met), a mitochondria-targeted analog derived from conjugating the anti-diabetic drug metformin with a triphenylphosphonium functional group, and then evaluated the preclinical efficacy of Mito-Met in cell culture and MitoPark animal models of PD...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38442389/retinestatin-a-polyol-polyketide-from-a-termite-nest-derived-streptomyces-sp
#22
JOURNAL ARTICLE
Thanh-Hau Huynh, Hee Kyung Kim, Jayho Lee, Yeon Hee Ban, Yong-Joon Jang, Bo Eun Heo, Thanh Quang Nguyen, Joon Soo An, Yun Kwon, Sang-Jip Nam, Jichan Jang, Ki-Bong Oh, Min-Kyoo Shin, Dong-Chan Oh
A new polyol polyketide, named retinestatin ( 1 ), was obtained and characterized from the culture of a Streptomyces strain, which was isolated from a subterranean nest of the termite Reticulitermes speratus kyushuensis Morimoto. The planar structure of 1 was elucidated on the basis of the cumulative analysis of ultraviolet, infrared, mass spectrometry, and nuclear magnetic resonance spectroscopic data. The absolute configuration of 1 at 12 chiral centers was successfully assigned by employing a J -based configuration analysis in combination with ROESY correlations, a quantum mechanics-based computational approach to calculate NMR chemical shifts, and a 3 min flash esterification by Mosher's reagents followed by NMR analysis...
March 5, 2024: Journal of Natural Products
https://read.qxmd.com/read/38440878/study-on-red-blood-cell-distribution-width-in-children-with-severe-mycoplasma-pneumoniae-pneumonia
#23
JOURNAL ARTICLE
Lin Wu, Jinyan Zhang, Hui-Min Zhang, Cheng-Yi Wang
Background: This study aimed to investigate the clinical value of the red blood cell distribution width (RDW) in severe Mycoplasma pneumoniae pneumonia (MPP). Methods: A total of 185 children with diagnosed severe MPP were included. The patients' case records and laboratory examination data were analyzed retrospectively. The children were grouped into quartiles based on RDW. Results: Univariate analysis revealed that RDW was significantly correlated with the Pediatric Risk of Mortality (PRISM) III score, Sepsis-Related Organ Failure Assessment score, incidence of invasive intubation and 30-day in-hospital mortality...
March 5, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38435183/the-impact-of-respiratory-function-training-and-rehabilitation-nursing-on-the-recovery-of-patients-with-mycoplasma-pneumoniae-pneumonia
#24
JOURNAL ARTICLE
Humayun Saleem, Sarosh Khan Jadoon, Amna Akbar, Nisha Hamid Awan, Emama Arshad Abbasi, Javeria Qadeer Abbasi, Soffia Khursheed, Jhanzeb Ahmed, Mohammad Saleem Khan, Sabahat Tasneem
Introduction The goal of this study was to see how people who had been diagnosed with Mycoplasma pneumoniae pneumonia (MPP) responded to respiratory function training and rehabilitation (RFTR) nursing. Methodology A total of 122 patients (five to 12 years of age) diagnosed with Mycoplasma pneumoniae pneumonia (MPP) and refractory Mycoplasma pneumoniae pneumonia (RMPP) using enzyme-linked immunoassay and PCR were included in this study. These patients were hospitalized at a tertiary care hospital from February 2022 to December 2022...
February 2024: Curēus
https://read.qxmd.com/read/38433962/tetramic-acid-motif-natural-products-from-a-marine-fungus-tolypocladium-cylindrosporum-fb06-and-their-anti-parkinson-activities
#25
JOURNAL ARTICLE
Yuna Jung, Chaesun Kwon, Taeyeon Kim, Jin Woo Lee, Min-Kyoo Shin, Sang Hee Shim
UNLABELLED: Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological activities. In the present study, two new tetramic acid alkaloids tolypyridone I ( 1 ) and tolypyridone J ( 2 ), together with five known ones ( 3 - 7 ), were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North Alaska...
February 2024: Marine life science & technology
https://read.qxmd.com/read/38433309/clinical-performance-of-custom-milled-polyetherketoneketone-pekk-posts-and-cores-a-12-month-follow-up-randomized-controlled-pilot-study
#26
JOURNAL ARTICLE
Naif Ghanem, Hasan Ali, Nasser Bahrli, Hazem Hassan
OBJECTIVES: Comparing the survival rate and the cumulative success rates of custom-milled polyetherketone ketone posts and cores (MPP) with prefabricated fiber posts (PFP) in restoring compromised endodontically treated premolars. MATERIAL AND METHODS: This was a randomized, double-blind, parallel, two-arm controlled pilot study. A total of 24 patients (12 males, 12 females), each had a compromised lower premolar, needed a root canal treatment and to be restored with post and core...
April 2024: Clinical and Experimental Dental Research
https://read.qxmd.com/read/38431178/circhivep2-alleviates-parkinson-s-nerve-damage-and-inflammatory-response-by-targeting-mir-485-3p
#27
JOURNAL ARTICLE
Xia Lin, Lingqun Mao, Qiuyue Chen, Tianyu Wang, Taotao Tao, Luping Pan
OBJECTIVE: Dysregulation of covalently closed circular RNAs (circRNAs) has been associated with neurological disorders, the role of circHIVP2 in Parkinson's disease (PD) and its molecular mechanism is not well understood. METHODS: 127 patients with PD and 85 healthy people were enrolled. RT-qPCR was employed to examine the levels of circHIVEP2. ROC curve to explore the diagnostic. Mpp + induced the SH-SY-5Y to construct an in vitro PD cell model. Cell viability, apoptosis, and secretion levels of inflammatory factors were analyzed by CCK-8, flow cytometry, and ELISA assay...
February 29, 2024: Experimental Gerontology
https://read.qxmd.com/read/38430183/effect-of-wechat-based-medication-guidance-on-symptoms-and-serological-parameters-in-children-with-mycoplasma-pneumoniae
#28
JOURNAL ARTICLE
Ke Gao, Ke Zeng, Xiping Yu, Wu Zhao, Yanyan Qiu, Yuyang Li, Zhifei Li
OBJECTIVE: The aim of this study was to assess the effect of microsoft-based medication guidance on the level of symptoms and serological indicators in children receiving budesonide nebulisation combined with terbutaline for the treatment of Mycoplasma pneumoniae pneumoniae (MPP). METHODS: A total of 109 children with MPP treated in The First Affiliated Hospital of Ningbo University of China between October 2022 and April 2023 were divided into the conventional group (n=54, with medication guidance by telephone follow-up) and the WeChat group (n=55, with medication guidance based on the WeChat platform) using a randomized number table...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38428788/effects-of-polypropylene-microplastics-on-carbon-dioxide-dynamics-in-intertidal-mangrove-sediments
#29
JOURNAL ARTICLE
Xubing Lin, Shuying Lin, Licheng Peng, Miao Chen, Xing Cheng, Shiyu Xie, Ruiqi Bao, Yuanyuan Su, Tariq Mehmood
Microplastics (MPs) in soil can influence CO2 dynamics by altering organic carbon (OC) and microbial composition. Nevertheless, the fluctuation of CO2 response attributed to MPs in mangrove sediments is unclear. This study explores the impact of micro-sized polypropylene (mPP) particles on the carbon dynamics of intertidal mangrove sediments. In the high-tide level sediment, after 28 days, the cumulative CO2 levels for varying mPP dosages were as follows: 496.86 ± 2.07, 430.38 ± 3...
February 28, 2024: Environmental Pollution
https://read.qxmd.com/read/38426012/pulmonary-siderosis-complicated-with-severe-mycoplasma-pneumoniae-pneumonia-a-case-report
#30
Zhen Huang, Tao Cheng, Guangwen Chen
Idiopathic pulmonary hemosiderosis (IPH) is a rare and fatal lung disease. Mycoplasma pneumoniae pneumonia (MPP) is the main community-acquired pneumonia among children aged 5 and above in China. We report the following case of IPH complicated with severe mycoplasma pneumoniae pneumonia(SMPP). An 8-year-old boy with cough and fever was diagnosed with IPH for 3 years and his chest computed tomography showed bilateral bronchopneumonia, lobular consolidation and subpleural interstitial fibrosis. As far as we know, IPH related to SMPP is rarely reported...
2024: Respiratory Medicine Case Reports
https://read.qxmd.com/read/38414754/apoptosis-signal-regulating-kinase-1-ask1-deficiency-alleviates-mpp-induced-impairment-of-evoked-dopamine-release-in-the-mouse-hippocampus
#31
JOURNAL ARTICLE
Fang Zhao, Chuhan Li, Yinghan Zhuang, Yan Yan, Yanqin Gao, Thomas Behnisch
The dopaminergic system is susceptible to dysfunction in numerous neurological diseases, including Parkinson's disease (PD). In addition to motor symptoms, some PD patients may experience non-motor symptoms, including cognitive and memory deficits. A possible explanation for their manifestation is a disturbed pattern of dopamine release in brain regions involved in learning and memory, such as the hippocampus. Therefore, investigating neuropathological alterations in dopamine release prior to neurodegeneration is imperative...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38412883/multipoint-pacing-for-cardiac-resynchronization-is-the-mpp-juice-worth-the-battery-squeeze
#32
EDITORIAL
Wissam Mekary, Faisal M Merchant
No abstract text is available yet for this article.
February 25, 2024: American Journal of Cardiology
https://read.qxmd.com/read/38410419/construction-and-validation-of-a-nomogram-model-to-predict-the-severity-of-mycoplasma-pneumoniae-pneumonia-in-children
#33
JOURNAL ARTICLE
Li Li, Run Guo, Yingxue Zou, Xu Wang, Yifan Wang, Shiying Zhang, Huihua Wang, Xingnan Jin, Ning Zhang
BACKGROUND: This study aimed to develop a nomogram model for early prediction of the severe Mycoplasma pneumoniae pneumonia (MPP) in children. METHODS: A retrospective analysis was conducted on children with MPP, classifying them into severe and general MPP groups. The risk factors for severe MPP were identified using Logistic Stepwise Regression Analysis, followed by Multivariate Regression Analysis to construct the nomogram model. The model's discrimination was evaluated using a receiver operating characteristic curve, its calibration with a calibration curve, and the results were visualized using the Hosmer-Lemeshow goodness-of-fit test...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38408954/differences-in-anterior-chamber-depth-in-keratoconus-patients-with-binocular-very-asymmetry-ectasia
#34
JOURNAL ARTICLE
Zizhen Wang, Haowen Ma, Yu Zhang, Yifei Yuan, Yan Liu, Yueguo Chen
BACKGROUND: To evaluate the difference in anterior chamber depth (ACD) between two eyes among keratoconus patients with binocular very asymmetric ectasia (VAE) and to explore the influencing factors. METHODS: The corneal curvature and ACD in both eyes of patients with VAE were measured by Sirius (version 3.2, CSO, Italy) at the following points: corneal vertex, maximum curvature (apex), and the 1.5 mm, 2.5 mm, and 3.5 mm superior-, inferior-, nasal-, temporal-paracentral from center...
February 26, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38407560/the-schizotrophic-lifestyle-of-sclerotinia-sclerotiorum
#35
REVIEW
Qingna Shang, Daohong Jiang, Jiatao Xie, Jiasen Cheng, Xueqiong Xiao
Sclerotinia sclerotiorum is a cosmopolitan and typical necrotrophic phytopathogenic fungus that infects hundreds of plant species. Because no cultivars highly resistant to S. sclerotiorum are available, managing Sclerotinia disease caused by S. sclerotiorum is still challenging. However, recent studies have demonstrated that S. sclerotiorum has a beneficial effect and can live mutualistically as an endophyte in graminaceous plants, protecting the plants against major fungal diseases. An in-depth understanding of the schizotrophic lifestyle of S...
February 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38407218/serum-il-17a-and-il-6-in-pediatric-mycoplasma-pneumoniae-pneumonia-implications-for-different-endotypes
#36
JOURNAL ARTICLE
Heng Wang, Yanli Zhang, Chengsong Zhao, Yun Peng, Wenqi Song, Weihan Xu, Xiaohui Wen, Jinrong Liu, Haiming Yang, Ruihe Shi, Shunying Zhao
Pediatric Mycoplasma pneumoniae pneumonia (MPP) is a heterogeneous disease with a diverse spectrum of clinical phenotypes. No studies have demonstrated the relationship between underlying endotypes and clinical phenotypes as well as prognosis about this disease. Thus, we conducted a multicentre prospective longitudinal study on children hospitalized for MPP between June 2021 and March 2023, with the end of follow-up in August 2023. Blood samples were collected and processed at multiple time points. Multiplex cytokine assay was performed to characterize serum cytokine profiles and their dynamic changes after admission...
February 26, 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38405353/dimethyl-fumarate-exerts-a-neuroprotective-effect-by-enhancing-mitophagy-via-the-nrf2-bnip3-pink1-axis-in-the-mpp-iodide-induced-parkinson-s-disease-mice-model
#37
JOURNAL ARTICLE
Poojitha Pinjala, Kamatham Pushpa Tryphena, Amrita Kulkarni, Prince Giri Goswami, Dharmendra Kumar Khatri
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder linked to the loss of dopaminergic neurons in the substantia nigra. Mitophagy, mitochondrial selective autophagy, is critical in maintaining mitochondrial and subsequently neuronal homeostasis. Its impairment is strongly implicated in PD and is associated with accelerated neurodegeneration. OBJECTIVE: To study the positive effect of dimethyl fumarate (DMF) on mitophagy via the NRF2/BNIP3/PINK1 axis activation in PD disease models...
2024: JAD Reports
https://read.qxmd.com/read/38404789/metabolomics-comparison-of-metabolites-and-functional-pathways-in-the-sh-sy5y-cell-model-of-parkinson-s-disease-under-pemf-exposure
#38
JOURNAL ARTICLE
Li-Na Zhu, Deng Chen, Chengqi He
OBJECTIVE: PEMF is an emerging technique in the treatment of Parkinson's disease (PD) due to its potential improvement of movement speed. The aim of this study was to investigate the metabolic profiles of pulsed electromagnetic fields (PEMFs) in an SH-SY5Y cell model of PD. METHODS: The SH-SY5Y cell model of PD was induced by 1-methyl-4-phenylpyridinium (MPP+ ). Liquid chromatography mass spectrometry (LC‒MS)-based untargeted metabolomics was performed to examine changes in the PD cell model with or without PEMF exposure...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38393695/exogenous-application-of-pectin-triggers-stomatal-closure-and-immunity-in-arabidopsis
#39
JOURNAL ARTICLE
Cheng Zhang, Charles Tetteh, Sheng Luo, Pinyuan Jin, Xingqian Hao, Min Sun, Nan Fang, Yingjun Liu, Huajian Zhang
Pectin has been extensively studied in animal immunity, and exogenous pectin as a food additive can provide protection against inflammatory bowel disease. However, the utility of pectin to improve immunity in plants is still unstudied. Here, we found exogenous application of pectin triggered stomatal closure in Arabidopsis in a dose- and time-dependent manner. Additionally, pectin activated peroxidase and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase to produce reactive oxygen species (ROS), which subsequently increased cytoplasmic Ca2+ concentration ([Ca2+ ]cyt ) and was followed by nitric oxide (NO) production, leading to stomatal closure in an abscisic acid (ABA) and salicylic acid (SA) signalling-dependent mechanism...
February 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38393681/phytoplasma-a-plant-pathogen-that-cannot-be-ignored-in-agricultural-production-research-progress-and-outlook
#40
REVIEW
Ruotong Wang, Bixin Bai, Danyang Li, Jingke Wang, Weijie Huang, Yunfeng Wu, Lei Zhao
Phytoplasmas are phloem-restricted plant-pathogenic bacteria transmitted by insects. They cause diseases in a wide range of host plants, resulting in significant economic and ecological losses worldwide. Research on phytoplasmas has a long history, with significant progress being made in the past 30 years. Notably, with the rapid development of phytoplasma research, scientists have identified the primary agents involved in phytoplasma transmission, established classification and detection systems for phytoplasmas, and 243 genomes have been sequenced and assembled completely or to draft quality...
February 2024: Molecular Plant Pathology
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