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Hai-Jie Yang, Xiang Shi, Fei Ju, Bei-Ning Hao, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Mian Wang
The cold shock protein RBM3 can mediate mild hypothermia-related protection in neurodegeneration such as Alzheimer's disease. However, it remains unclear whether RBM3 and mild hypothermia provide same protection in model of Parkinson's disease (PD), the second most common neurodegenerative disorder. In this study, human SH-SY5Y neuroblastoma cells subjected to insult by 1-methyl-4-phenylpyridinium (MPP+ ) served as an in-vitro model of PD. Mild hypothermia (32°C) aggravated MPP+ -induced apoptosis, which was boosted when RBM3 was silenced by siRNA...
2018: Frontiers in Neuroscience
Jing-Si Zhou, Zhou Zhu, Feng Wu, Ying Zhou, Rui Sheng, Jun-Chao Wu, Zheng-Hong Qin
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). Although the pathogenic mechanism underlying PD remains largely unknown, decreased nigral glutathione (GSH) in postmortem brains of PD patients supports the presence of oxidative stress in PD. We found that Nicotinamide adenine dinucleotide phosphate (NADPH), which is important for maintaining the level of GSH, protected dopaminergic (DA) neurons from neurotoxicity of MPTP/MPP+ ...
May 16, 2018: Acta Pharmacologica Sinica
Ligang Zheng, Gang Li, Yalei Wang, Xiaochao Zhu, Rongkun Pan, Yan Wang
To investigate the effect of blockage ratios on the explosion suppression by powder suppressant, an experimental study was performed to suppress the methane-air explosion in a 5L duct with different blockage ratios and various concentrations of BC dry powder. The results indicate that flames experienced both the spherical and finger-shaped stages. Furthermore, the smoothness of flame front initially decreased and then increased. Flame propagation velocities were higher with larger blockage ratios except for φ = 1...
April 27, 2018: Journal of Hazardous Materials
Imran Niazi, James Baker, Raffaele Corbisiero, Charles Love, David Martin, Robert Sheppard, Seth J Worley, Niraj Varma, Kwangdeok Lee, Gery Tomassoni
OBJECTIVES: The MultiPoint Pacing (MPP) trial assessed the safety and efficacy of pacing 2 left ventricular sites with a quadripolar lead in patients with heart failure indicated for a CRT-D device. BACKGROUND: Cardiac resynchronization therapy nonresponse is a complex problem where stimulation of multiple left ventricular sites may be a solution. METHODS: Enrolled patients were indicated for a CRT-D system. Bi-ventricular (Bi-V) pacing was activated at implant...
December 26, 2017: JACC. Clinical Electrophysiology
Xuan Li, Xin-Xin Cui, Ya-Jing Chen, Ting-Ting Wu, Huaxi Xu, Huiyong Yin, Yun-Cheng Wu
As the main transcription factor that regulates the cellular responses to hypoxia, Hypoxia-inducible factor-1α (HIF-1α) plays an important role in the pathogenesis of Parkinson's disease (PD). HIF-1α is normally degraded through ubiquitination after hydroxylation by prolyl hydroxylases (PHD). Emerging evidence has suggested that HIF PHD inhibitors (HIF-PHI) may have neuroprotective effects on PD through increasing HIF-1α levels. However, the therapeutic benefit of HIF-PHI for PD remains poorly explored due to the lack of proper clinical compounds and understanding of the underlying molecular mechanisms...
2018: Frontiers in Aging Neuroscience
Hyun Ho Lee, Vance N Owens, Sungkyun Park, Jiwoong Kim, Chang Oh Hong
Although a number of studies have examined cadmium (Cd) immobilization by phosphate (P) in soils, determining the exact mechanism of Cd immobilization in various conditions, including P chemical form, P rate, and inherent Cd concentrations in soil has not been examined. The objective of this study was to determine changes in Cd immobilization through adsorption and precipitation in different conditions. Arable soils were spiked with inorganic Cd to give a total Cd concentration of 10, 100, and 1000 mg Cd kg-1 ...
May 10, 2018: Chemosphere
Eric Wildon Kostuk, Jingli Cai, Lorraine Iacovitti
BACKGROUND: Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared. Mechanisms underlying the selective protection of the VTA and susceptibility of the SN are still mostly unknown. Here, we demonstrate the importance of balance between astrocytes and microglia in the susceptibility of SN DA neurons to the PD mimetic toxin 1-methyl-4-phenylpyridinium (MPP+ )...
May 11, 2018: Journal of Neuroinflammation
Yan-Ru Li, Guo-Hui Li, Lin Sun, Lin Li, Yue Liu, De-Gang Kong, Shu-Qi Wang, Dong-Mei Ren, Xiao-Ning Wang, Hong-Xiang Lou, Tao Shen
Oxidative stress and inflammation undoubtedly contribute to the pathogenesis of many human diseases. The nuclear transcription factor erythroid 2-related factor (Nrf2) and the nuclear factor κ B (NF- κ B) play central roles in regulation of oxidative stress and inflammation and thus are targets for developing agents against oxidative stress- and inflammation-related diseases. Our previous study indicated that the EtOH extract of Litsea garrettii protected human bronchial epithelial cells against oxidative insult via the activation of Nrf2...
2018: Oxidative Medicine and Cellular Longevity
Goodwell Nzou, R T Wicks, E E Wicks, S A Seale, C H Sane, A Chen, S V Murphy, J D Jackson, A J Atala
The integral selectivity characteristic of the blood brain barrier (BBB) limits therapeutic options for many neurologic diseases and disorders. Currently, very little is known about the mechanisms that govern the dynamic nature of the BBB. Recent reports have focused on the development and application of human brain organoids developed from neuro-progenitor cells. While these models provide an excellent platform to study the effects of disease and genetic aberrances on brain development, they may not model the microvasculature and BBB of the adult human cortex...
May 9, 2018: Scientific Reports
Hee-Young Kim, Hyongjun Jeon, Hyungwoo Kim, Sungtae Koo, Seungtae Kim
Sophora flavescens Aiton (SF) has been used to treat various diseases including fever and inflammation in China, South Korea and Japan. Several recent reports have shown that SF has anti-inflammatory and anti-apoptotic effects, indicating that it is a promising candidate for treatment of Parkinson's disease (PD). We evaluated the protective effect of SF against neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+ )-induced mitochondrial dysfunction in SH-SY5Y human neuroblastoma cells, an in vitro PD model. SH-SY5Y cells were incubated with SF for 24 h, after which they were treated with MPP+ ...
2018: Frontiers in Aging Neuroscience
Jun-Fang Chen, Man Wang, Ying-Han Zhuang, Thomas Behnisch
Parkinson's disease is a progressive neurological disease characterized by the degeneration of dopaminergic neurons in the substantia nigra. A highly similar pattern of neurodegeneration can be induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium ion (MPP+ ), which cause the death of dopaminergic neurons. Administration of MPTP or MPP+ results in Parkinson's disease-like symptoms in rodents. However, it remains unclear whether intracerebroventricular MPP+ administration affects neurogenesis in the substantia nigra and subgranular zone or whether brain-derived neurotrophic factor alters the effects of MPP+ ...
April 2018: Neural Regeneration Research
Rostand B Tayong, Jacques A Manyo Manyo, Emmanuel Siryabe, Guy E Ntamack
This study deals with the deduction of parameters of Micro-Perforated Panel (MPP) systems from impedance tube data. It is shown that there is an ambiguity problem that exists between the MPP thickness and its open area ratio. This problem makes it difficult to invert the reflection coefficient data fitting and therefore to deduct the MPP parameters. A technique is proposed to reduce this ambiguity by using an equation that links the hole diameter to the open area ratio. Reflection coefficient data obtained for two specimens with different characteristics is employed for searching the MPP parameters using a simulated annealing algorithm...
April 2018: Journal of the Acoustical Society of America
Guifang Wang, Weibin Ma, Jingwei Du
Parkinson's disease (PD) is one of the most common neurodegenerative diseases resulting from the continuous death of dopaminergic neurons in substantia nigra. MPP+ (1-methyl-4-phenylpyridinium) has been reported to be a major neurotoxin causing neurotoxic insults on dopaminergic neurons in humans. β-Caryophyllene (BCP), an important cannabinoid derived from the essential oils of different species, has displayed pharmacological properties in different kinds of tissues and cells. However, neuroprotective effects of BCP in PD haven't been reported before...
April 25, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Shuhei Takahashi, Akinori Hisatsune, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki
Polysulfides are endogenous sulfur-containing molecular species that may regulate various cellular functions. Here we examined the effect of polysulfides exogenously applied to rat midbrain slice cultures, to address their potential neuroprotective actions. Na2 S3 at concentrations of 10 μM or higher prevented 1-methyl-4-phenylpyridinium (MPP+ )-induced loss of dopaminergic neurons. Na2 S4 at 10 μM also protected dopaminergic neurons from MPP+ cytotoxicity, whereas Na2 S and Na2 S2 at the same concentration had no significant effect...
April 20, 2018: Journal of Pharmacological Sciences
Mara Zilocchi, Giovanna Finzi, Marta Lualdi, Fausto Sessa, Mauro Fasano, Tiziana Alberio
Mitochondrial impairment is one of the most important hallmarks of Parkinson's disease (PD) pathogenesis. In this work, we wanted to verify the molecular basis of altered mitochondrial dynamics and disposal in Substantia nigra specimens of sporadic PD patients, by the comparison with two cellular models of PD. Indeed, SH-SY5Y cells were treated with either dopamine or 1-methyl-4-phenylpyridinium (MPP+ ) in order to highlight the effect of altered dopamine homeostasis and of complex I inhibition, respectively...
April 25, 2018: Neurochemistry International
Nicolas Giguere, Consiglia Pacelli, Caroline Saumure, Marie-Josee Bourque, Diana Matheoud, Daniel Levesque, Ruth S Slack, David S Park, Louis-Eric Trudeau
Many mutations in genes encoding proteins such as parkin, PTEN-induced putative kinase 1 (PINK1), protein deglycase DJ-1 (DJ-1 or PARK7), leucine-rich repeat kinase 2 (LRRK2), and α-synuclein have been linked to familial forms of Parkinson's disease (PD). The consequences of these mutations, such as altered mitochondrial function and pathological protein aggregation, are starting to be better understood. However, little is known about the mechanisms explaining why alterations in such diverse cellular mechanisms lead to the selective loss of dopamine (DA) neurons in the substantia nigra (SNc) in the brain of individuals with PD...
April 26, 2018: Journal of Biological Chemistry
Priscila Peña-Diaz, Jan Mach, Eva Kriegová, Pavel Poliak, Jan Tachezy, Julius Lukeš
Upon their translocation into the mitochondrial matrix, the N-terminal pre-sequence of nuclear-encoded proteins undergoes cleavage by mitochondrial processing peptidases. Some proteins require more than a single processing step, which involves several peptidases. Down-regulation of the putative Trypanosoma brucei mitochondrial intermediate peptidase (MIP) homolog by RNAi renders the cells unable to grow after 48 hours of induction. Ablation of MIP results in the accumulation of the precursor of the trypanosomatid-specific trCOIV protein, the largest nuclear-encoded subunit of the cytochrome c oxidase complex in this flagellate...
2018: PloS One
Shijing Tan, Yanan Dai, Shengmin Zhang, Liming Liu, Jin Zhao, Hrvoje Petek
Charge transfer in transduction of light to electrical or chemical energy at heterojunctions of metals with semiconductors or semimetals is believed to occur by photogenerated hot electrons in metal undergoing incoherent internal photoemission through the heterojunction interface. Charge transfer, however, can also occur coherently by dipole coupling of electronic bands at the heterojunction interface. Microscopic physical insights into how transfer occurs can be elucidated by following the coherent polarization of the donor and acceptor states on the time scale of electronic dephasing...
March 23, 2018: Physical Review Letters
Yuan Xu, Feng Zhi, Ya Peng, Naiyuan Shao, Dhiaedin Khiati, Gianfranco Balboni, Yilin Yang, Ying Xia
There is emerging evidence suggesting that neurotoxic insults and hypoxic/ischemic injury are underlying causes of Parkinson's disease (PD). Since PTEN-induced kinase 1 (PINK1) dysfunction is involved in the molecular genesis of PD and since our recent studies have demonstrated that the δ-opioid receptor (DOR) induced neuroprotection against hypoxic and 1-methyl-4-phenyl-pyridimium (MPP+ ) insults, we sought to explore whether DOR protects neuronal cells from hypoxic and/or MPP+ injury via the regulation of PINK1-related pathways...
April 24, 2018: Molecular Neurobiology
Sergio Motta, Ugo Cesari, Mariano Paternoster, Giovanni Motta, Giuseppe Orefice
OBJECTIVE: To verify possible relations between vocal disability and aerodynamic measures in selected Parkinson's disease (PD) patients with low/moderate-grade dysphonia. METHODS: Fifteen idiopathic dysphonic PD male patients were examined and compared with 15 euphonic subjects. Testing included the following measures: Voice Handicap Index (VHI), maximum phonation time (MPT), mean estimated subglottal pressure (MESGP), mean sound pressure level (MSPL), mean phonatory power (MPP), mean phonatory efficiency (MPE) and mean phonatory resistance (MPR)...
April 23, 2018: European Archives of Oto-rhino-laryngology
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