keyword
https://read.qxmd.com/read/38495920/the-clinical-value-of-systemic-immune-inflammation-index-sii-in-predicting-the-severity-of-hospitalized-children-with-mycoplasma-pneumoniae-pneumonia-a-retrospective-study
#1
JOURNAL ARTICLE
Shuye Wang, Yu Wan, Wenbo Zhang
OBJECTIVE: The Systemic Immune Inflammation Index (SII), as a novel inflammation biomarker that comprehensively reflects the inflammatory and immune status of the body, has not been reported in studies on Mycoplasma pneumoniae pneumonia (MPP) in children. This study aims to investigate whether SII can serve as an effective indicator for evaluating the condition of MPP. METHODS: This study recruited a total of 304 hospitalized patients with mycoplasma pneumoniae pneumonia (MPP), including 78 patients with severe MPP (SMPP) and 226 patients with non-SMPP...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38483039/moati1-mediates-mitophagy-by-facilitating-recruitment-of-moatg8-to-promote-invasive-growth-in-magnaporthe-oryzae
#2
JOURNAL ARTICLE
Huanbin Shi, Shuai Meng, Jiehua Qiu, Shuwei Xie, Nan Jiang, Chaoxi Luo, Naweed I Naqvi, Yanjun Kou
Mitophagy is a selective autophagy for the degradation of damaged or excessive mitochondria to maintain intracellular homeostasis. In Magnaporthe oryzae, a filamentous ascomycetous fungus that causes rice blast, the most devastating disease of rice, mitophagy occurs in the invasive hyphae to promote infection. To date, only a few proteins are known to participate in mitophagy and the mechanisms of mitophagy are largely unknown in pathogenic fungi. Here, by a yeast two-hybrid screen with the core autophagy-related protein MoAtg8 as a bait, we obtained a MoAtg8 interactor MoAti1 (MoAtg8-interacting protein 1)...
March 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38481338/srec-dependent-adaption-to-host-iron-environments-regulates-the-transition-of-trophic-stages-and-developmental-processes-of-curvularia-lunata
#3
JOURNAL ARTICLE
Jiaying Sun, Jiamei Zhao, Miaomiao Liu, Jiayang Li, Jie Cheng, Wenling Li, Mingyue Yuan, Shuqin Xiao, Chunsheng Xue
Plant pathogens are challenged by host-derived iron starvation or excess during infection, but the mechanism of plant pathogens rapidly adapting to the dynamic host iron environments to assimilate iron for invasion and colonization remains largely unexplored. Here, we found that the GATA transcription factor SreC in Curvularia lunata is required for virulence and adaption to the host iron excess environment. SreC directly binds to the ATGWGATAW element in an iron-dependent manner to regulate the switch between different iron assimilation pathways, conferring adaption to host iron environments in different trophic stages of C...
March 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38479556/early-b-cell-factor-3-ebf3-attenuates-parkinson-s-disease-through-directly-regulating-contactin-associated-protein-like-4-cntnap4-transcription-an-experimental-study
#4
JOURNAL ARTICLE
Wentao Hu, Menghan Wang, Guifang Sun, Limin Zhang, Hong Lu
Parkinson's disease (PD) is a gradually debilitating neurodegenerative syndrome. Here, we analyzed GSE7621 chip data obtained from the Gene Expression Omnibus (GEO) database to explore the pathogenesis of PD. Early B Cell Factor 3 (EBF3), a member of the highly evolutionarily conserved EBF-transcription factor family, is involved in neuronal development. EBF3 expression is low in the substantia nigra of patients with PD. However, whether EBF3 is implicated in dopaminergic neuron death during PD has not yet been investigated...
March 11, 2024: Cellular Signalling
https://read.qxmd.com/read/38476886/programmed-cell-death-4-blocks-autophagy-and-promotes-dopaminergic-neuronal-injury-in-parkinson-s-disease
#5
JOURNAL ARTICLE
Guiling Cao, Tao Kang, Nini Li, Peng Li
Dysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N-SH cells with 1-methyl-4-phenylpyridinium (MPP+ ) to establish an in vitro model of PD...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38476108/alternaria-diseases-on-potato-and-tomato
#6
REVIEW
Tamara Schmey, Christopher S Tominello-Ramirez, Carolin Brune, Remco Stam
UNLABELLED: Alternaria spp. cause different diseases in potato and tomato crops. Early blight caused by Alternaria solani and brown spot caused by Alternaria alternata are most common, but the disease complex is far more diverse. We first provide an overview of the Alternaria species infecting the two host plants to alleviate some of the confusion that arises from the taxonomic rearrangements in this fungal genus. Highlighting the diversity of Alternaria fungi on both solanaceous hosts, we review studies investigating the genetic diversity and genomes, before we present recent advances from studies elucidating host-pathogen interactions and fungicide resistances...
March 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38476100/a-type-vi-secretion-system-effector-tseg-of-pantoea-ananatis-is-involved-in-virulence-and-antibacterial-activity
#7
JOURNAL ARTICLE
Xiaozhen Zhao, Lu Gao, Qurban Ali, Chenjie Yu, Bingqin Yuan, Hai Huang, Juying Long, Qin Gu, Huijun Wu, Xuewen Gao
The type VI secretion system (T6SS) of many gram-negative bacteria injects toxic effectors into adjacent cells to manipulate host cells during pathogenesis or to kill competing bacteria. However, the identification and function of the T6SS effectors remains only partly known. Pantoea ananatis, a gram-negative bacterium, is commonly found in various plants and natural environments, including water and soil. In the current study, genomic analysis of P. ananatis DZ-12 causing brown stalk rot on maize demonstrated that it carries three T6SS gene clusters, namely, T6SS-1, T6SS-2, and T6SS-3...
March 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38475340/fire-retardant-flexible-foamed-polyurethane-pu-based-composites-armed-and-charmed-ground-tire-rubber-gtr-particles
#8
JOURNAL ARTICLE
Paulina Kosmela, Kamila Sałasińska, Daria Kowalkowska-Zedler, Mateusz Barczewski, Adam Piasecki, Mohammad Reza Saeb, Aleksander Hejna
Inadequate fire resistance of polymers raises questions about their advanced applications. Flexible polyurethane (PU) foams have myriad applications but inherently suffer from very high flammability. Because of the dependency of the ultimate properties (mechanical and damping performance) of PU foams on their cellular structure, reinforcement of PU with additives brings about further concerns. Though they are highly flammable and known for their environmental consequences, rubber wastes are desired from a circularity standpoint, which can also improve the mechanical properties of PU foams...
February 28, 2024: Polymers
https://read.qxmd.com/read/38473763/linalool-a-fragrance-compound-in-plants-protects-dopaminergic-neurons-and-improves-motor-function-and-skeletal-muscle-strength-in-experimental-models-of-parkinson-s-disease
#9
JOURNAL ARTICLE
Wan-Hsuan Chang, Hung-Te Hsu, Chih-Cheng Lin, Li-Mei An, Chien-Hsing Lee, Horng-Huey Ko, Chih-Lung Lin, Yi-Ching Lo
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in reduced dopamine levels in the striatum and eventual onset of motor symptoms. Linalool (3,7-dimethyl-1,6-octadien-3-ol) is a monoterpene in aromatic plants exhibiting antioxidant, antidepressant, and anti-anxiety properties. The objective of this study is to evaluate the neuroprotective impacts of linalool on dopaminergic SH-SY5Y cells, primary mesencephalic and cortical neurons treated with 1-methyl-4-phenylpyridinium ion (MPP+ ), as well as in PD-like mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38467038/uniaxial-oriented-perovskite-films-with-controllable-orientation
#10
JOURNAL ARTICLE
Dongni Li, Xiangyu Sun, Yao Zhang, Zhen Guan, Yansong Yue, Qingya Wang, Lu Zhao, Fangze Liu, Jing Wei, Hongbo Li
Perovskite films with large crystal size, preferred orientation, and facile fabrication process, combining advantages of single-crystal and polycrystalline films, have gained considerable attention recently. However, there is little research on the facet properties of perovskite films. Here, (111)- and (001)-oriented perovskite films with bandgaps ranging from 1.53 to 1.77 eV, and systematically investigated their orientation-dependent properties are achieved. The (111)-oriented films show electron-dominated traps and the (001)-oriented films show hole-dominated traps, which are related to their atomic arrangement at the surface...
March 11, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38466231/uncovering-protac-sensitivity-and-efficacy-by-multidimensional-proteome-profiling-a-case-for-stat3
#11
JOURNAL ARTICLE
Yuying Suo, Daohai Du, Chao Chen, Hongwen Zhu, Xiongjun Wang, Nixue Song, Dayun Lu, Yaxi Yang, Jiacheng Li, Jun Wang, Zhongyuan Luo, Bing Zhou, Cheng Luo, Hu Zhou
Proteolysis-targeting chimera (PROTAC) is a powerful technology that can effectively trigger the degradation of target proteins. The intricate interplay among various factors leads to a heterogeneous drug response, bringing about significant challenges in comprehending drug mechanisms. Our study applied data-independent acquisition-based mass spectrometry to multidimensional proteome profiling of PROTAC (DIA-MPP) to uncover the efficacy and sensitivity of the PROTAC compound. We profiled the signal transducer and activator of transcription 3 (STAT3) PROTAC degrader in six leukemia and lymphoma cell lines under multiple conditions, demonstrating the pharmacodynamic properties and downstream biological responses...
March 11, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38466045/investigation-on-the-band-narrowing-and-shifting-effects-of-micro-perforated-panel-absorbers
#12
JOURNAL ARTICLE
Yujie Qian, Zhengyuan Gao, Jie Zhang, Yuliang Wei
Micro-perforated panel (MPP) absorbers exhibit multiple resonance bands with increased bandwidth narrowing and shifting in higher frequencies, limiting their effectiveness. This study investigates the effects of narrowing and shifting in higher-order resonance bands of MPP absorbers. First, an acoustic impedance model for MPP absorbers is introduced, and the narrowing and shifting coefficients are defined and modeled to quantify these effects. It is observed that a larger ratio of acoustic resistance to acoustic mass is favorable for reducing the narrowing and shifting effects...
March 1, 2024: Journal of the Acoustical Society of America
https://read.qxmd.com/read/38463592/clinical-significance-of-measuring-mp-dna-c-reactive-protein-and-inflammatory-cytokines-in-children-with-mycoplasma-pneumoniae-pneumonia
#13
JOURNAL ARTICLE
Wangqiang Li, Fang Deng
OBJECTIVE: To explore the clinical significance of detecting mycoplasma pneumoniae (MP)-DNA, C-reactive protein (CRP), interleukin-6 (IL-6), IL-8, and IL-10 in children with mycoplasma pneumoniae pneumonia (MPP). METHODS: The data from 106 children who received treatment or underwent health examination in the Children's Medical Center of Anhui Medical University from January 2021 to October 2022 were collected and analyzed retrospectively. The observation group (OG) consisted of 64 children with MPP, while the control group (CG) consisted of 42 healthy children...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38462784/mining-oomycete-proteomes-for-phosphatome-leads-to-the-identification-of-specific-expanded-phosphatases-in-oomycetes
#14
JOURNAL ARTICLE
Min Qiu, Yaru Sun, Siqun Tu, Huaibo Li, Xin Yang, Haiyang Zhao, Maozhu Yin, Yaning Li, Wenwu Ye, Ming Wang, Yuanchao Wang
Phosphatases are important regulators of protein phosphorylation and various cellular processes, and they serve as counterparts to kinases. In this study, our comprehensive analysis of oomycete complete proteomes unveiled the presence of approximately 3833 phosphatases, with most species estimated to have between 100 and 300 putative phosphatases. Further investigation of these phosphatases revealed a significant increase in protein serine/threonine phosphatases (PSP) within oomycetes. In particular, we extensively studied the metallo-dependent protein phosphatase (PPM) within the PSP family in the model oomycete Phytophthora sojae...
March 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38462774/knockout-of-sldcl2b-attenuates-the-resistance-of-tomato-to-potato-spindle-tuber-viroid-infection
#15
JOURNAL ARTICLE
Yuhong Zhang, Xiaxia Tian, Huiyuan Xu, Binhui Zhan, Changyong Zhou, Shifang Li, Zhixiang Zhang
RNA interference, or RNA silencing, is an important defence mechanism against viroid infection in plants. Plants encode multiple DICER-LIKE (DCL) proteins that are key components of the RNA silencing pathway. However, the roles of different DCLs in defence responses against viroid infection remain unclear. Here, we determined the function of tomato DCL2b (SlDCL2b) in defence responses against potato spindle tuber viroid (PSTVd) infection using SlDCL2b loss-of-function tomato mutant plants. Compared with wild-type plants, mutant plants were more susceptible to PSTVd infection, developing more severe symptoms earlier and accumulating higher levels of PSTVd RNAs...
March 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38460112/genome-wide-association-analysis-reveals-genes-controlling-an-antagonistic-effect-of-biotic-and-osmotic-stress-on-arabidopsis-thaliana-growth
#16
JOURNAL ARTICLE
Pingping Huang, Mohamed El-Soda, Katarzyna W Wolinska, Kaige Zhao, Nelson H Davila Olivas, Joop J A van Loon, Marcel Dicke, Mark G M Aarts
While the response of Arabidopsis thaliana to drought, herbivory or fungal infection has been well-examined, the consequences of exposure to a series of such (a)biotic stresses are not well studied. This work reports on the genetic mechanisms underlying the Arabidopsis response to single osmotic stress, and to combinatorial stress, either fungal infection using Botrytis cinerea or herbivory using Pieris rapae caterpillars followed by an osmotic stress treatment. Several small-effect genetic loci associated with rosette dry weight (DW), rosette water content (WC), and the projected rosette leaf area in response to combinatorial stress were mapped using univariate and multi-environment genome-wide association approaches...
March 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38460111/maize-catalases-are-recruited-by-a-virus-to-modulate-viral-multiplication-and-infection
#17
JOURNAL ARTICLE
Yiying Tian, Zhiyuan Jiao, Fangfang Qi, Wendi Ma, Yuming Hao, Xinyu Wang, Liyang Xie, Tao Zhou, Zaifeng Fan
Given the detrimental effects of excessive reactive oxygen species (ROS) accumulation in plant cells, various antioxidant mechanisms have evolved to maintain cellular redox homeostasis, encompassing both enzymatic components (e.g., catalase, superoxide dismutase) and non-enzymatic ones. Despite extensive research on the role of antioxidant systems in plant physiology and responses to abiotic stresses, the potential exploitation of antioxidant enzymes by plant viruses to facilitate viral infection remains insufficiently addressed...
March 2024: Molecular Plant Pathology
https://read.qxmd.com/read/38458660/stimulation-of-estrogen-receptor-alpha-by-hydroxyanilide-fungicide-fenhexamid-promotes-lipid-accumulation-in-3%C3%A2-t3-l1-adipocyte
#18
JOURNAL ARTICLE
Da-Woon Jung, Da-Hyun Jeong, Hee-Seok Lee
Fenhexamid are fungicides that act against plant pathogens by inhibiting sterol biosynthesis. Nonetheless, it can trigger endocrine disruption and promote breast cancer cell growth. In a recent study, we investigated the mechanism underlying the lipid accumulation induced by fenhexamid hydroxyanilide fungicides in 3 T3-L1 adipocytes. To examine the estrogen receptor alpha (ERα)-agonistic effect, ER transactivation assay using the ERα-HeLa-9903 cell line was applied, and fenhexamid-induced ERα agonist effect was confirmed...
February 2024: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/38457855/developmental-programming-of-production-and-reproduction-in-dairy-cows-iv-association-of-maternal-milk-fat-and-protein-percentage-and-milk-fat-to-protein-ratio-with-offspring-s-birth-weight-survival-productive-and-reproductive-performance-and-amh-concentration
#19
JOURNAL ARTICLE
Emadeddin Mobedi, Hamid Reza Dehghan Harati, Iman Allahyari, Faramarz Gharagozlou, Mehdi Vojgani, Reza Hemmati Baghbanani, Amirsina Akbarinejad, Vahid Akbarinejad
Although the association of maternal milk production with developmental programming of offspring has been investigated, there is limited information available on the relationship of maternal milk components with productive and reproductive performance of the offspring. Therefore, the present study was conducted to analyze the association of maternal milk fat and protein percentage and milk fat to protein ratio with birth weight, survival, productive and reproductive performance and AMH concentration in the offspring...
March 2, 2024: Theriogenology
https://read.qxmd.com/read/38456423/dimensional-regulation-from-1d-3d-to-2d-3d-of-perovskite-interfaces-for-stable-inverted-perovskite-solar-cells
#20
JOURNAL ARTICLE
Ting Wang, Leyu Bi, Liu Yang, Zixin Zeng, Xiaofei Ji, Ziyang Hu, Sai-Wing Tsang, Hin-Lap Yip, Qiang Fu, Alex K-Y Jen, Yongsheng Liu
Constructing low-dimensional/three-dimensional (LD/3D) perovskite solar cells can improve efficiency and stability. However, the design and selection of LD perovskite capping materials are incredibly scarce for inverted perovskite solar cells (PSCs) because LD perovskite capping layers often favor hole extraction and impede electron extraction. Here, we develop a facile and effective strategy to modify the perovskite surface by passivating the surface defects and modulating surface electrical properties by incorporating morpholine hydriodide (MORI) and thiomorpholine hydriodide (SMORI) on the perovskite surface...
March 8, 2024: Journal of the American Chemical Society
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