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https://www.readbyqxmd.com/read/28440831/systematic-investigations-on-fused-%C3%AF-system-compounds-of-seven-benzene-rings-prepared-by-photocyclization-of-diphenanthrylethenes
#1
Shota Fujino, Minoru Yamaji, Hideki Okamoto, Toshiki Mutai, Isao Yoshikawa, Hirohiko Houjou, Fumito Tani
We studied the photoproducts of 1-(n-phenanthryl)-2-(m-phenanthryl)ethenes (nEm; n, m = 1, 3 and 9) for understanding photocyclization patterns based on NMR spectroscopy. The crystal structures of the photoproducts were analyzed by X-ray crystallography, and the photophysical features of the photocyclized molecules were investigated based on emission and transient absorption measurements. Phenanthrene derivatives substituted at the 1- and 3-positions were prepared for synthesizing nEm by photocyclization of stilbene derivatives...
April 25, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28439401/long-non-coding-rna-malat1-contributes-to-cell-apoptosis-by-sponging-mir-124-in-parkinson-disease
#2
Wei Liu, Qishun Zhang, Jianlei Zhang, Wujun Pan, Jingya Zhao, Yuming Xu
BACKGROUND: Parkinson disease (PD) is the most common movement disturbance characterized by the loss of dopaminergic (DA) neurons in midbrain. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is aberrantly expressed in neurons and is involved in the dendritic and synapse development. However, the role of MALAT1 and its underlying mechanism in PD remain to be defined. METHODS: The expressions of MALAT1 and miR-124 were evaluated by qRT-PCR. N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice and SH-SY5Y cells subjected to N-methyl-4-phenylpyridinium (MPP(+)) were utilized to investigate the effect of MALAT1 on PD...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28435870/nanoparticles-that-do-not-adhere-to-mucus-provide-uniform-and-long-lasting-drug-delivery-to-airways-following-inhalation
#3
Craig S Schneider, Qingguo Xu, Nicholas J Boylan, Jane Chisholm, Benjamin C Tang, Benjamin S Schuster, Andreas Henning, Laura M Ensign, Ethan Lee, Pichet Adstamongkonkul, Brian W Simons, Sho-Yu S Wang, Xiaoqun Gong, Tao Yu, Michael P Boyle, Jung Soo Suk, Justin Hanes
Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that avoid mucoadhesion and have diameters smaller than mucus mesh spacings rapidly penetrate mucus layers [mucus-penetrating particles (MPP)], which we hypothesized would provide prolonged lung retention compared to MAP...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28432572/micropapillary-bladder-cancer-a-clinico-pathological-characterization-and-treatment-analysis
#4
Z Li, H Liao, Z Tan, D Mao, Y Wu, Y M Xiao, S K Yang, L Zhong
PURPOSE: Micropapillary bladder cancer (MPBC) is a very rare and aggressive variant of urothelial carcinoma (UC). The aim of this study was to investigate the clinico-pathological characteristics, treatment, and prognosis of MPBC to improve the understanding of this invasive disease. METHODS: We reviewed the records of 6 patients with MPBC who were evaluated and treated at our hospital between 2009 and 2015, and additionally reviewed 38 cases reported in the literature...
April 21, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28429275/tgf-%C3%AE-1-neuroprotection-via-inhibition-of-microglial-activation-in-a-rat-model-of-parkinson-s-disease
#5
Xiao Chen, Zhan Liu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Peng
Transforming growth factor (TGF)-β1 is a pleiotropic cytokine with immunosuppressive and anti-inflammatory properties. Recently we have shown that TGF-β1 pretreatment in vitro protects against 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic neuronal loss that characterizes in Parkinson's disease (PD). Herein, we aimed to demonstrate that TGF-β1 administration in vivo after MPP(+) toxicity has neuroprotection that is achieved by a mediation of microglia. A rat model of PD was prepared by injecting MPP(+) unilaterally in the striatum...
April 20, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28422042/synchronous-penoscrotal-implantation-of-penile-prosthesis-and-artificial-urinary-sphincter-after-radical-prostatectomy
#6
Deniz Bolat, Zafer Kozacioglu, Salih Polat, Omer Koras, Murat Arslan, Suleyman Minareci
OBJECTIVES: To evaluate the results of synchronous dual implantation of penile (PP) and artificial urinary sphincter prosthesis (AUSP) in patients with severe erectile dysfunction (ED) and urinary incontinence (UI) after radical prostatectomy (RP). METHODS: Between January 2006 and March 2015, patients who underwent synchronous dual implantation of PP for severe post-RP ED and AUSP for moderate to severe post-RP UI in our clinic were screened retrospectively. The erectile function and the continence status were evaluated by the questionnaires of IIEF-5 and ICIQ-SF...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28421199/valproic-acid-protects-primary-dopamine-neurons-from-mpp-induced-neurotoxicity-involvement-of-gsk3%C3%AE-phosphorylation-by-akt-and-erk-through-the-mitochondrial-intrinsic-apoptotic-pathway
#7
Chi Zhang, Xianrui Yuan, Zhongliang Hu, Songlin Liu, Haoyu Li, Ming Wu, Jian Yuan, Zijin Zhao, Jun Su, Xiangyu Wang, Yiwei Liao, Qing Liu
Valproic acid (VPA), a drug widely used to treat manic disorder and epilepsy, has recently shown neuroprotective effects in several neurological diseases, particularly in Parkinson's disease (PD). The goal of the present study was to confirm VPA's dose-dependent neuroprotective propensities in the MPP(+) model of PD in primary dopamine (DA) neurons and to investigate the underlying molecular mechanisms using specific mitogen-activated protein kinases (MAPKs) and phosphatidylinositol 3-kinase- (PI3K-) Akt signaling inhibitors...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28403117/association-of-the-ace-gstm1-il-6-nos3-and-cyp1a1-polymorphisms-with-susceptibility-of-mycoplasma-pneumoniae-pneumonia-in-chinese-children
#8
Jie Zhao, Wen Zhang, Li Shen, Xiaomeng Yang, Yi Liu, Zhongtao Gai
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia (CAP) and the clinical presentation of mycoplasma pneumoniae pneumonia (MPP) varies widely. Genetic variability affecting the host response may also influence the susceptibility to MPP. Several studies have investigated the association between single nucleotide polymorphism (SNP) of some genes and the risks of CAP; however, the results were inconsistent. Here, we investigated the association of 5 functional genes and the risks of MPP, including ACE (rs4340), GSTM1 (Ins/del), IL-6 (rs1800795), NOS3 (rs1799983), and CYP1A1 (rs2606345) in a total of 715 subjects (415 cases, 300 controls) by using tetra-primer allele-specific polymerase chain reaction (PCR) and Sanger sequencing...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28391698/pegylated-nanoemulsions-for-oral-delivery-role-of-the-inner-core-on-the-final-fate-of-the-formulation
#9
Manuel J Santander-Ortega, Maria Plaza-Oliver, Virginia Rodriguez-Robledo, Lucia Castro-Vazquez, Noemi Villaseca-Gonzalez, Joaquin Gonzalez-Fuentes, Emilio L Cano, Pilar Marcos, Maria Victoria Lozano, Maria Mar Arroyo-Jimenez
During the last decade, there has been growing interest to grant nanoparticles with diffusion properties across mucosae. In this sense, the non-ionic block copolymer Pluronic F127 (PF127) has arisen as a promising coating agent to formulate mucus penetrating particles (MPP). In the journey to find efficient coating agents, most of the studies have been focused more on the effect of the coating agent architecture rather than on the role the physicochemical properties of the nanoparticle used as substrate...
April 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28381988/increased-excitatory-synaptic-transmission-of-dentate-granule-neurons-in-mice-lacking-psd-95-interacting-adhesion-molecule-neph2-kirrel3-during-the-early-postnatal-period
#10
Junyeop D Roh, Su-Yeon Choi, Yi Sul Cho, Tae-Yong Choi, Jong-Sil Park, Tyler Cutforth, Woosuk Chung, Hanwool Park, Dongsoo Lee, Myeong-Heui Kim, Yeunkum Lee, Seojung Mo, Jeong-Seop Rhee, Hyun Kim, Jaewon Ko, Se-Young Choi, Yong Chul Bae, Kang Shen, Eunjoon Kim, Kihoon Han
Copy number variants and point mutations of NEPH2 (also called KIRREL3) gene encoding an immunoglobulin (Ig) superfamily adhesion molecule have been linked to autism spectrum disorders, intellectual disability and neurocognitive delay associated with Jacobsen syndrome, but the physiological roles of Neph2 in the mammalian brain remain largely unknown. Neph2 is highly expressed in the dentate granule (DG) neurons of the hippocampus and is localized in both dendrites and axons. It was recently shown that Neph2 is required for the formation of mossy fiber filopodia, the axon terminal structure of DG neurons forming synapses with GABAergic neurons of CA3...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28380449/is-mpp-a-good-prognostic-factor-in-stage-iii-lung-adenocarcinoma-with-egfr-exon-19-mutation
#11
Zhang Tian, Wang Jing, Su Yanjun, Chen Xi, Yan Qingna, Li Qi, Sun Leina, Wang Yuwen, Er Puchun, Pang Qingsong, Wang Ping
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein encoded by a gene located in the short arm of chromosome 7. This study aimed to investigate the clinicopathologic characteristics of classic EGFR exon mutation in Chinese patients with TMN stage III lung adenocarcinoma who received radical surgery. A total of 1,801 lung adenocarcinomas were analyzed for mutations in EGFR; 35% exhibited mutation of classic EGFR exons. Clinical and pathologic characteristics of patients with EGFR exon 19 mutation were compared with those who harbored EGFR exon 21 mutation...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28366826/a-natural-product-from-cannabis-sativa-subsp-sativa-inhibits-homeodomain-interacting-protein-kinase-2-hipk2-attenuating-mpp-induced-apoptosis-in-human-neuroblastoma-sh-sy5y-cells
#12
Guan Wang, Lingjuan Zhu, Yuqian Zhao, Suyu Gao, Dejuan Sun, Jingquan Yuan, Yuxin Huang, Xue Zhang, Xinsheng Yao
Homeodomain-interacting protein kinase 2 (HIPK2) is a conserved serine/threonine kinase, which regulate transcription, cell differentiation, proliferation and apoptosis. Previous evidences indicated that HIPK2 could be involved in the pathogenesis of neurodegenerative diseases, suggesting as a novel target for Parkinson's disease (PD) therapeutic development. Herein, gene microarray analysis was performed to verify the key regulatory function of HIPK2 in PD. (Z)-methylp-hydroxycinnamate (ZMHC, 7) with other eighteen compounds were isolated from Cannabis sativa subsp...
March 30, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28365714/microrna-181a-regulates-apoptosis-and-autophagy-process-in-parkinson-s-disease-by-inhibiting-p38-mitogen-activated-protein-kinase-mapk-c-jun-n-terminal-kinases-jnk-signaling-pathways
#13
Ying Liu, Yanfeng Song, Xiaotun Zhu
BACKGROUND microRNA (miR)-181a has been reported to be downregulated in Parkinson's disease (PD), but the regulatory mechanism of miR-181a on neuron apoptosis and autophagy is still poorly understood. We aimed to investigate the neuroprotective effects of miR-181a on PD in vitro. MATERIAL AND METHODS Human SK-N-SH neuroblastoma cells were incubated with different concentrations of 1-methyl-4-phenylpyridinium ion (MPP+) to induce the PD model. The expression of miR-181a was then analyzed. After transfection with miR-181a mimic or scramble following MPP+ treatment, the expression of autophagy protein markers (LC3II, LC3I, and Beclin 1) and p38 mitogen-activated protein kinase (MAPK)/c-Jun N-terminal kinases (JNK) signaling proteins (p-p38, p38, p-JNK, and JNK) and cell apoptosis were detected...
April 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28363126/interaction-between-the-zebrafish-danio-rerio-organic-cation-transporter-1-oct1-and-endo-and-xenobiotics
#14
Ivan Mihaljević, Marta Popović, Roko Žaja, Nikola Maraković, Goran Šinko, Tvrtko Smital
Organic cation transporters (OCTs) serve as uptake transporters of numerous endo- and xenobiotics. They have been in the focus of medical toxicological research for more than a decade due to their key role in absorption, distribution, metabolism and excretion due to their expression on basolateral membranes of various barrier tissues. OCTs belong to the SLC22A family within the SLC (Solute carrier) protein superfamily, with three co-orthologs identified in humans (OCT1, 2 and 3), and two Oct orthologs in zebrafish (Oct1 and Oct2)...
March 18, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28357529/differentiating-pheochromocytoma-from-lipid-poor-adrenocortical-adenoma-by-ct-texture-analysis-feasibility-study
#15
Gu-Mu-Yang Zhang, Bing Shi, Hao Sun, Zheng-Yu Jin, Hua-Dan Xue
OBJECTIVES: To investigate the feasibility of using CT texture analysis (CTTA) to differentiate pheochromocytoma from lipid-poor adrenocortical adenoma (lp-ACA). METHODS: Ninety-eight pheochromocytomas and 66 lp-ACAs were included in this retrospective study. CTTA was performed on unenhanced and enhanced images. Receiver operating characteristic (ROC) analysis was performed, and the area under the ROC curve (AUC) was calculated for texture parameters that were significantly different for the objective...
March 29, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28356907/neuroprotective-effect-and-mechanism-of-thiazolidinedione-on-dopaminergic-neurons-in-vivo-and-in-vitro-in-parkinson-s-disease
#16
Yanqin Wang, Weilin Zhao, Ge Li, Jinhu Chen, Xin Guan, Xi Chen, Zhenlong Guan
The aim of the present study was to gain insight into the neuroprotection effects and mechanism of thiazolidinedione pioglitazone in both in vitro and in vivo MPP(+)/MPTP induced PD models. In vivo experimental results showed that oral treatment of pioglitazone resulted in significant improvements in behavior symptoms damaged by MPTP and increase in the survival of TH positive neurons in the pioglitazone intervention groups. In addition, oral treatment of pioglitazone increased the expression of peroxisome proliferator-activated receptor-γ coactivator of 1α (PGC-1α) and increased the number of mitochondria, along with an observed improvement in mitochondrial ultrastructure...
2017: PPAR Research
https://www.readbyqxmd.com/read/28355695/-oxidative-stress-and-autophagy-in-sk-n-sh-cells-induced-by-manganese-chloride-or-1-methyl-4-phenylpyridinium-a-comparative-analysis
#17
W L Liu, C S Dou, Y Wang, P Zhao, J L Fu, B Y Yao, Z C Zhou
Objective: To investigate the effect of manganese chloride (MnCl(2)) or 1-methyl-4-phenylpyridinium (MPP (+)) on oxidative stress and autophagy in human neuroblastomaSK-N-SH cells and the mechanism of the neurotoxicity of manganese. Methods: SK-N-SH cells were treated with MnCl(2) or MPP(+) at doses of 0.062 5, 0.125, 0.25, 0.5, 1.0, and 2.0 mmol/L for 24 hours, and MTT assay was used to measure cell viability. The cells weretreated with MnCl(2) or MPP(+) at doses of 0.125, 0.25, and 0.5 mmol/L for 24 hours, and flow cytometry was used to measure the content of reactive oxygen species (ROS) in cells, a laser scanning confocal microscope was used to observe autophagosome in cells, and Western blot was used to measure the expression of autophagy-related proteins P62 and LC3-II/LC3-I...
February 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28338362/the-effects-of-caffeine-taurine-or-caffeine-taurine-co-ingestion-on-repeat-sprint-cycling-performance-and-physiological-responses
#18
Rory Warnock, Owen Jeffries, Stephen Patterson, Mark Waldron
PURPOSE: This study investigated the effects of caffeine (C), taurine (T), caffeine and taurine co-ingestion (C+T) or placebo (P) on repeated Wingate cycling performance and associated physiological responses. METHODS: Seven male team sports players participated in a randomised, single-blind, cross-over study, where they completed three Wingate tests, each separated by 2-min, an hour after ingesting: C (5 mg/kg BM), T (50 mg/kg BM), C+T (5 mg/kg BM + 50 mg/kg BM) or P (5 mg/kg BM) in a gelatine capsule...
March 24, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28337124/interleukin-4-protects-dopaminergic-neurons-in-vitro-but-is-dispensable-for-mptp-induced-neurodegeneration-in-vivo
#19
Laura Hühner, Jennifer Rilka, Ralf Gilsbach, Xiaolai Zhou, Venissa Machado, Björn Spittau
Microglia are involved in physiological as well as neuropathological processes in the central nervous system (CNS). Their functional states are often referred to as M1-like and M2-like activation, and are believed to contribute to neuroinflammation-mediated neurodegeneration or neuroprotection, respectively. Parkinson's disease (PD) is one the most common neurodegenerative disease and is characterized by the progressive loss of midbrain dopaminergic (mDA) neurons in the substantia nigra resulting in bradykinesia, tremor, and rigidity...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28336299/inhibitory-effect-of-crizotinib-on-creatinine-uptake-by-renal-secretory-transporter-oct2
#20
Hiroshi Arakawa, Saki Omote, Ikumi Tamai
Crizotinib, a tyrosine kinase inhibitor, exhibits some cases of an increase in serum creatinine levels. Creatinine is secreted by not only glomerular filtration, but also active secretion by organic cation transporters such as organic cation transporter 2 (OCT2). In the present study, we evaluated in vitro inhibitory effect of crizotinib on OCT2 by directly measuring creatinine uptake by OCT2. Co-incubation of crizotinib reduced uptake of [(14)C]creatinine by cultured HEK293 cells expressing OCT2 (HEK293/OCT2) in a concentration-dependent manner with IC50 values of 1...
March 20, 2017: Journal of Pharmaceutical Sciences
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