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https://www.readbyqxmd.com/read/28932127/an-in-vitro-model-of-renal-inflammation-after-ischemic-oxidative-stress-injury-nephroprotective-effects-of-a-hyaluronan-ester-with-butyric-acid-on-mesangial-cells
#1
Olga Baraldi, Francesca Bianchi, Viola Menghi, Andrea Angeletti, Anna Laura Croci Chiocchini, Maria Cappuccilli, Valeria Aiello, Giorgia Comai, Gaetano La Manna
BACKGROUND: Acute kidney injury, known as a major trigger for organ fibrosis and independent predictor of chronic kidney disease, is characterized by mesangial cell proliferation, inflammation and unbalance between biosynthesis and degradation of extracellular matrix. Therapeutic approaches targeting the inhibition of mesangial cell proliferation and matrix expansion may represent a promising opportunity for the treatment of kidney injury. An ester of hyaluronic acid and butyric acid (HB) has shown vasculogenic and regenerative properties in renal ischemic-damaged tissues, resulting in enhanced function recovery and minor degree of inflammation in vivo...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28926242/structure-function-studies-of-artemisia-tridentata-farnesyl-diphosphate-synthase-and-chrysanthemyl-diphosphate-synthase-by-site-directed-mutagenesis-and-morphogenesis
#2
J Scott Lee, Jian-Jung Pan, Gurusankar Ramamoorthy, C Dale Poulter
The amino acid sequences of farnesyl diphosphate synthase (FPPase) and chrysanthemyl diphosphate synthase (CPPase) from Artemisia tridentata ssp. Spiciformis, minus their chloroplast targeting regions, are 71% identical and 90% similar. FPPase efficiently and selectively synthesizes the "regular" sesquiterpenoid farnesyl diphosphate (FPP) by coupling isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) and then to geranyl diphosphate (GPP). In contrast, CPPase is an inefficient promiscuous enzyme, which synthesizes the "irregular" monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, in addition to coupling IPP to DMAPP...
September 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28922532/redox-modulatory-mn3o4-nanozyme-with-multi-enzyme-activity-provides-efficient-cytoprotection-to-human-cells-in-parkinson-s-disease-model
#3
Govindasamy Mugesh, Namrata Singh, Mohammed Azharuddin Savanur, Shubhi Srivastava, Patrick D'Silva
Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3O4 nanozyme functionally mimic three major antioxidant enzymes, i.e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology-dependent. The redox modulatory effect of Mn3O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders...
September 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28887333/rapid-estrogen-receptor-alpha-signaling-mediated-by-erk-activation-regulates-vascular-tone-in-male-and-ovary-intact-female-mice
#4
Seong Chul Kim, Austin C Boese, Matthew H Moore, Rea M Cleland, Lin Chang, Patrice Delafontaine, Ke-Jie Yin, Jean-Pyo Lee, Milton H Hamblin
Estrogen has been shown to affect vascular reactivity. Here, we assessed estrogen receptor-alpha (ERα) dependency of estrogenic effects on vasorelaxation via a rapid nongenomic pathway in both male and ovary-intact female mice. We compared the effect of a primary estrogen, 17 beta-estradiol (E2) or 4,4',4"-(4-propyl-[1H]pyrazole-1,3,5-triyl)tris-phenol (PPT) (selective ERα agonist). We found that E2 and PPT induced greater aortic relaxation in females than males, indicating ERα mediation, which is further validated by employing ERα antagonism...
September 8, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28887039/activation-of-the-hmgb1-rage-axis-upregulates-th-expression-in-dopaminergic-neurons-via-jnk-phosphorylation
#5
Soo Jeong Kim, Min Jeong Ryu, Jeongsu Han, Yunseon Jang, Jungim Kim, Min Joung Lee, Ilhwan Ryu, Xianshu Ju, Eungseok Oh, Woosuk Chung, Gi Ryang Kweon, Jun Young Heo
The derangement of tyrosine hydroxylase (TH) activity reduces dopamine synthesis and is implicated in the pathogenesis of Parkinson's disease. However, the extracellular modulator and intracellular regulatory mechanisms of TH have yet to be identified. Recently, high-mobility group box 1 (HMGB1) was reported to be actively secreted from glial cells and is regarded as a mediator of dopaminergic neuronal loss. However, the mechanism for how HMGB1 affects TH expression, particularly through the receptor for advanced glycation endproducts (RAGE), has not yet been investigated...
September 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28884481/estrogen-receptor-%C3%AE-selective-agonist-ameliorates-liver-cirrhosis-in-rats-by-inhibiting-the-activation-and-proliferation-of-hepatic-stellate-cells
#6
Bin Zhang, Cheng-Gang Zhang, Lin-Hua Ji, Gang Zhao, Zhi-Yong Wu
AIM: To explore the roles of ER subtypes and corresponding agonists/antagonists on the development of cirrhosis and activation and proliferation of HSCs. METHODS: Carbon tetrachloride (CCl4 ) -induced cirrhotic ovariectomized rats were administered non-selective ER agonist (β-estradiol, E2), ER selective agonists (ERα agonist, PPT; ERβ agonist, DPN; GPER agonist, G1) or E2 + ER selective antagonists (ERα antagonist, MPP; ERβ antagonist, PHTPP; GPER antagonist, G15) for 12 weeks...
September 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28884356/diagnostic-value-of-mri-based-3d-texture-analysis-for-tissue-characterisation-and-discrimination-of-low-grade-chondrosarcoma-from-enchondroma-a-pilot-study
#7
Catharina S Lisson, Christoph G Lisson, Kerstin Flosdorf, Regine Mayer-Steinacker, Markus Schultheiss, Alexandra von Baer, Thomas F E Barth, Ambros J Beer, Matthias Baumhauer, Reinhard Meier, Meinrad Beer, Stefan A Schmidt
OBJECTIVES: To explore the diagnostic value of MRI-based 3D texture analysis to identify texture features that can be used for discrimination of low-grade chondrosarcoma from enchondroma. METHODS: Eleven patients with low-grade chondrosarcoma and 11 patients with enchondroma were retrospectively evaluated. Texture analysis was performed using mint Lesion: Kurtosis, entropy, skewness, mean of positive pixels (MPP) and uniformity of positive pixel distribution (UPP) were obtained in four MRI sequences and correlated with histopathology...
September 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28881646/modeling-african-american-prostate-adenocarcinoma-by-inducing-defined-genetic-alterations-in-organoids
#8
Kenji Unno, Meejeon Roh, Young A Yoo, Yousef Al-Shraideh, Lu Wang, Larisa Nonn, Sarki A Abdulkadir
Genomic studies are rapidly identifying genetic alterations in human cancer, but functional validation of such alterations has been slow. Here, using human prostate cancer as a model, we have assessed the feasibility of engineering defined genetic alterations in well-known cancer driver genes to transform benign prostate epithelial organoids derived from African American men. Benign human prostate organoids were transduced with lentiviruses expressing MYC, shPTEN, shTP53 and AR, alone and in various combinations, to recapitulate prostate cancer development...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878229/hydrogen-bond-based-smart-polymer-for-highly-selective-and-tunable-capture-of-multiply-phosphorylated-peptides
#9
Guangyan Qing, Qi Lu, Xiuling Li, Jing Liu, Mingliang Ye, Xinmiao Liang, Taolei Sun
Multisite phosphorylation is an important and common mechanism for finely regulating protein functions and subsequent cellular responses. However, this study is largely restricted by the difficulty to capture low-abundance multiply phosphorylated peptides (MPPs) from complex biosamples owing to the limitation of enrichment materials and their interactions with phosphates. Here we show that smart polymer can serve as an ideal platform to resolve this challenge. Driven by specific but tunable hydrogen bonding interactions, the smart polymer displays differential complexation with MPPs, singly phosphorylated and non-modified peptides...
September 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28874244/the-interplay-between-fasting-glucose-echocardiography-and-biomarkers-pathophysiological-considerations-and-prognostic-implications
#10
Manan Pareek
BACKGROUND: Traditional cardiovascular risk stratification tools that employ clinical risk factors are limited by their modest discriminative abilities. As such, robust cardiovascular risk assessment, including our understanding of the complex interplay between risk factors, in the primary preventive setting, remains incomplete. Phenotypical heterogeneity may be even greater among subjects with hyperglycemic conditions, i.e., prediabetes and diabetes, which is worrisome, given the dramatic global rise in mean fasting glucose levels, and the strong association with adverse cardiovascular outcomes...
September 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28869288/exploring-the-mechanism-of-jieduquyuziyin-prescription-on-systemic-lupus-erythematosus-by-gc-ms-based-urine-metabolomics
#11
Jing Wei, Jun Gao, Xinghong Ding
A urine metabolomics method based on gas chromatography mass spectrometry (GC-MS) was developed in order to investigate the metabolites characters of systemic lupus erythematosus (SLE) and therapeutic effects of jieduquyuziyin prescription (JP). The urinary metabolic profiles in urine specimens of the SLE model mice (MRL/lpr) group, prednisone acetate (PA)-treated SLE mice group, JP-treated SLE mice group, and control group (C57BL/6 J) after the administration were analyzed by GC-MS. These metabolic profiles were then processed by multivariate analysis, in particular Mass Profiler Professional (MPP), SIMCA-P and partial least-squares discriminant analysis (PLS-DA)...
September 4, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28853308/insulin-suppresses-mpp-induced-neurotoxicity-by-targeting-integrins-and-syndecans-in-c6-astrocytes
#12
Mahesh Ramalingam, Mi Hyun Cheng, Sung-Jin Kim
Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly. In central nervous system, astrocytes regulates neuronal function via the modulation of synaptic transmission and plasticity, secretion of growth factors, uptake of neurotransmitters and regulation of extracellular ion concentrations and metabolic support of neurons. Therefore, C6 astroglial cells have been used to study the in vitro PD model induced by 1-methyl-4-phenyl pyridinium (MPP(+)). In this study, pre-treatment of insulin inhibited MPP(+)-induced cell membrane damages on LDH and NO releases, which also inhibited the iNOS and Cox-2 levels...
August 30, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28852926/potential-molecular-mechanisms-mediating-the-protective-effects-of-tetrahydroxystilbene-glucoside-on-mpp-induced-pc12-cell-apoptosis
#13
Lingling Zhang, Linhong Huang, Xiaobing Li, Cuicui Liu, Xin Sun, Leitao Wu, Tao Li, Hao Yang, Jianzong Chen
Our previous work demonstrated that tetrahydroxystilbene glucoside (TSG) was able to effectively attenuate 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in PC12 cells partially via inhibiting reactive oxygen species (ROS) generation. However, the precise molecular mechanisms of TSG responsible for suppressing neuronal apoptosis have not been fully elucidated. To investigate the possible mechanism, we studied the neuroprotective effects of TSG on MPP(+)-induced PC12 cells apoptosis and explored the molecular mechanisms that mediated the effects of TSG...
August 29, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28851781/protocol-for-a-nationwide-survey-of-primary-health-care-in-china-the-china-peace-patient-centered-evaluative-assessment-of-cardiac-events-mpp-million-persons-project-primary-health-care-survey
#14
Meng Su, Qiuli Zhang, Jiapeng Lu, Xi Li, Na Tian, Yun Wang, Winnie Yip, Kar Keung Cheng, George A Mensah, Ralph I Horwitz, Elias Mossialos, Harlan M Krumholz, Lixin Jiang
INTRODUCTION: China has pioneered advances in primary health care (PHC) and public health for a large and diverse population. To date, the current state of PHC in China has not been subjected to systematic assessments. Understanding variations in primary care services could generate opportunities for improving the structure and function of PHC. METHODS AND ANALYSIS: This paper describes a nationwide PHC study (PEACE MPP Primary Health Care Survey) conducted across 31 provinces in China...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28846921/distinct-effects-of-estrogen-receptor-antagonism-on-object-recognition-and-spatial-memory-consolidation-in-ovariectomized-mice
#15
Jaekyoon Kim, Karyn M Frick
Exogenous treatment with the potent estrogen 17β-estradiol (E2) or selective estrogen receptor α/β (ERα/β) agonists enhances the consolidation of hippocampal-dependent object recognition (OR) and object placement (OP) memories in ovariectomized rodents. Although such data suggest that individual ERs are sufficient for memory consolidation, the necessity of a given ER for memory consolidation can only be demonstrated by blocking receptor function, for example with an ER antagonist. However, the effects on memory of antagonizing ERα or ERβ function are not well understood...
August 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28843681/effect-of-genetic-and-nongenetic-factors-on-chemical-composition-of-individual-milk-samples-from-dromedary-camels-camelus-dromedarius-under-intensive-management
#16
P Nagy, Zs N Fábri, L Varga, J Reiczigel, J Juhász
The aims of the present study were to monitor the changes in gross chemical composition of individual dromedary camel milk over a 5-yr period, to provide reference values, and to determine the effect of genetic and nongenetic factors influencing camel milk composition under intensive management. A total of 1,528 lactating dromedary camels were included in the study. Animals were fed a constant diet and were milked twice a day in a herringbone parlor. Milk samples were collected at monthly intervals using a sampling device and then fat, protein, lactose, total solids (TS), and solids-nonfat (SNF) concentrations of raw camel milk were determined with an automatic milk analyzer...
August 23, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28837077/electroacupuncture-promotes-recovery-of-motor-function-and-reduces-dopaminergic-neuron-degeneration-in-rodent-models-of-parkinson-s-disease
#17
Jaung-Geng Lin, Chao-Jung Chen, Han-Bin Yang, Yi-Hung Chen, Shih-Ya Hung
Parkinson's disease (PD) is a common neurodegenerative disease. The pathological hallmark of PD is a progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta in the brain, ultimately resulting in severe striatal dopamine deficiency and the development of primary motor symptoms (e.g., resting tremor, bradykinesia) in PD. Acupuncture has long been used in traditional Chinese medicine to treat PD for the control of tremor and pain. Accumulating evidence has shown that using electroacupuncture (EA) as a complementary therapy ameliorates motor symptoms of PD...
August 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28827046/%C3%AE-estradiol-3-benzoate-confers-neuroprotection-in-parkinson-mpp-rat-model-through-inhibition-of-lipid-peroxidation
#18
Yoshajandith Aguirre-Vidal, Antonio Monroy-Noyola, Laura Anaya-Ramos, Marcela Arteaga-Silva, Marisela Mendez-Armenta, Pedro Ostoa-Saloma, Mariana Díaz-Zaragoza, Jorge Morales-Montor, Camilo Ríos, Sergio Montes
Estradiol (E2), in addition to its known hormone function, is a neuroactive steroid that has shown neuroprotective profile in several models of neurological diseases. The present study explores the antioxidant effect of β-estradiol-3-benzoate (EB) on the neurotoxicity elicited by MPP(+) in rat striatum. Male Wistar rats, that were gonadectomized 30days prior to EB, were given 100µgEB per rat every 48h for 11days and animals were infused with MPP(+) via intrastriatal at day six after beginning EB treatment...
October 2017: Steroids
https://www.readbyqxmd.com/read/28822073/isorhynchophylline-attenuates-mpp-induced-apoptosis-through-endoplasmic-reticulum-stress-and-mitochondria-dependent-pathways-in-pc12-cells-involvement-of-antioxidant-activity
#19
Xiao-Ming Li, Xiao-Jie Zhang, Miao-Xian Dong
Endoplasmic reticulum stress (ERS) and mitochondrial dysfunctions are thought to be involved in the dopaminergic neuronal death in Parkinson's disease (PD). In this study, we found that isorhynchophylline (IRN) significantly attenuated 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptotic cell death and oxidative stress in PC12 cells. IRN markedly reduced MPP(+)-induced-ERS responses, indicative of inositol-requiring enzyme 1 (IRE1) phosphorylation and caspase-12 activation. Furthermore, IRN inhibits MPP(+)-triggered apoptosis signal-regulating kinase 1 (ASK1)/c-Jun N-terminal Kinase (JNK) signaling-mediated mitochondria-dependent apoptosis pathway...
August 18, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28821623/proteolytic-cleavage-by-the-imp-complex-or-oct1-peptidase-controls-the-localization-of-the-yeast-peroxiredoxin-prx1-to-distinct-mitochondrial-compartments
#20
Fernando Gomes, Flavio Romero Palma, Mario H Barros, Eduardo T Tsuchida, Helena G Turano, Thiago G P Alegria, Marilene Demasi, Luis E S Netto
Yeast Prx1 is a mitochondrial 1-Cys peroxiredoxin that catalyzes the reduction of endogenously generated H2O2 Prx1 is synthesized on cytosolic ribosomes as a preprotein with a cleavable N-terminal presequence that is the mitochondrial targeting signal, but the mechanisms underlying Prx1 distribution to distinct mitochondrial subcompartments are unknown. Here, we provide direct evidence of the following dual mitochondrial localization of Prx1: a soluble form in the intermembrane space and a form in the matrix weakly associated with the inner mitochondrial membrane...
August 18, 2017: Journal of Biological Chemistry
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