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Neuropathy AND Blood pressure

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https://www.readbyqxmd.com/read/29911044/advanced-diabetic-nephropathy-with-clean-eyes-an-extreme-phenotype
#1
Debmalya Sanyal, Sudip Chatterjee
Introduction: It is generally accepted that renal and eye changes in diabetes are concordant. There are however a fair number of patients with diabetes who have end-stage renal disease (ESRD) without any of the typical eye changes. The present study highlights the discordance between retinopathy and nephropathy and describes a series of patients of long-standing diabetes undergoing renal transplant who had little or no evidence of retinopathy. Methods: All patients with ESRD undergoing renal transplants underwent comprehensive fundus evaluation including dilated indirect ophthalmoscopy, slit lamp biomicroscopy, and fundus photography...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29892340/declining-trends-of-diabetic-nephropathy-retinopathy-and-neuropathy-with-improving-diabetes-care-indicators-in-japanese-patients-with-type-2-and-type-1-diabetes-jddm-46
#2
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Katsuya Yamazaki, Osamu Tomonaga, Shin-Ichiro Shirabe, Hiroshi Maegawa
Objective: We examined changes in prevalence of diabetic microvascular/macrovascular complications and diabetes care indicators for adults in Japan with type 2 and type 1 diabetes over one decade. Research design and methods: Two independent cohorts were recruited with the same inclusion criteria in 2004 (cohort 1: 3319 with type 2 and 286 with type 1 diabetes) and in 2014 (cohort 2: 3932 with type 2 and 308 with type 1 diabetes). Prevalence of complications and care indicators including achieving treatment targets for glycemia, blood pressure, lipid control, body mass index (BMI), and smoking were compared...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29862581/peripheral-neuropathy-in-diabetes-it-s-not-always-what-it-looks-like
#3
G Maltese, S V Tan, E Bruno, A Brackenridge, S Thomas
BACKGROUND: Hereditary Neuropathy with liability to Pressure Palsies (HNPP) is an autosomal dominant neuropathy, associated with deletion of the Peripheral Myelin Protein-22 (PMP-22) gene, causing recurrent painless palsies with age of onset between 10 and 30 years old. Only a few cases of Type 2 Diabetes and HNPP have been described and the coexistence of HNPP and Type 1 diabetes has never been reported. CASE REPORT: A 54-year old man with a history of Type 1 diabetes, managed with continuous subcutaneous insulin infusion (CSII), presented with deterioration of long-standing motor and sensory symptoms, previously attributed to golfer's elbow, diabetic neuropathy and spinal degenerative disease...
June 4, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29796437/leukemic-retinophaty-the-first-manifestation-in-a-case-of-acute-myelogenous-leukemia
#4
Oana Roxana Scripcă, Cristina Pădurariu, Neacșu Gheorghe Boricean, Loredana Botoș
A 42-year-old woman, without a specific medical history presented at the Department of Emergency Ophthalmology accusing marked decrease of vision for the left eye (VA 1/ 100). The eye examination revealed an optic neuropathy with multiple retinal hemorrhages at the level of both eyes, but more acutely on the left eye. The brain computer tomography (CT) excluded the suspicion of increasing intracranial pressure. The common blood tests such as complete blood count (CBC), erythrocyte sedimentation rate, and inflammatory markers raised a high suspicion of a malignant haematological disease...
January 2018: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29794815/increasing-sbp-variability-is-associated-with-an-increased-risk-of-developing-incident-diabetic-foot-ulcers
#5
Meghan B Brennan, Marylou Guihan, Elly Budiman-Mak, Hyojung Kang, Jennifer M Lobo, Bryn L Sutherland, Nicholas Emanuele, Elbert S Huang, Min-Woong Sohn
OBJECTIVE: SBP variability may be a target for mitigating end-organ damage associated with vascular disease. We evaluated the relationship between increased SBP variability and risk of incident diabetic foot ulceration. METHODS: Using a nested case-control design, we followed patients diagnosed with diabetes and treated within the US Department of Veterans Affairs Healthcare system for development of a diabetic foot ulcer (event) between 2006 and 2010. Each case was randomly matched to up to five controls based on age, sex, race/ethnicity, and calendar time...
May 22, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29771944/intraocular-pressure-and-its-normal-range-adjusted-for-ocular-and-systemic-parameters-the-beijing-eye-study-2011
#6
Ya Xing Wang, Liang Xu, Wen Bin Wei, Jost B Jonas
PURPOSE: To examine the distribution of intraocular pressure (IOP) in a normal population and the associations of IOP with other ocular and systemic parameters. METHODS: Out of 3468 participants of the population-based cross-sectional Beijing Eye Study 2011 we selected those individuals without glaucomatous optic neuropathy. The study particpants underwent a detailed ophthalmologic and systemic examination. IOP was measured by air puff non-contact tonometry. RESULTS: The study included 3135 eyes of 3135 participants with a mean age of 64...
2018: PloS One
https://www.readbyqxmd.com/read/29771733/haemodilution-and-head-down-tilting-induce-functional-injury-in-the-rat-optic-nerve-a-model-for-peri-operative-ischemic-optic-neuropathy
#7
Steven Roth, John Dreixler, Nancy J Newman
BACKGROUND: Mechanisms of peri-operative ischaemic optic neuropathy remain poorly understood. Both specific pre-operative and intra-operative factors have been examined by retrospective studies, but no animal model currently exists. OBJECTIVES: To develop a rodent model of peri-operative ischaemic optic neuropathy. In rats, we performed head-down tilt and/or haemodilution, theorising that the combination damages the optic nerve. DESIGN: Animal study...
May 15, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29735963/acupuncture-combined-with-hydrotherapy-in-diabetes-patients-with-mild-lower-extremity-arterial-disease-a-prospective-randomized-nonblinded-clinical-study
#8
Zhengqin Qi, Yan Pang, Lin Lin, Bing Zhang, Juntao Shao, Xiaodong Liu, Xin Zhang
BACKGROUND The aim of this pragmatic study was to explore the intervention of acupuncture combined with hydrotherapy and perceived effects in type 2 diabetic patients with recently diagnosed, mild, lower-extremity arterial disease (LEAD) in comparison with a control group. MATERIAL AND METHODS One hundred twenty-six diabetes patients who were diagnosed mild LEAD according to ankle-brachial blood pressure index (ABPI) and peripheral neuropathy symptom were randomly assigned to either an experimental (n=64) or control group (n=62)...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29735525/orthostatic-hypotension-and-risk-of-clinical-and-subclinical-cardiovascular-disease-in-middle-aged-adults
#9
Stephen P Juraschek, Natalie Daya, Lawrence J Appel, Edgar R Miller, John William McEvoy, Kunihiro Matsushita, Christie M Ballantyne, Elizabeth Selvin
BACKGROUND: Although orthostatic hypotension (OH) is a well-recognized manifestation of neuropathy and hypovolemia, its contribution to cardiovascular disease (CVD) risk is controversial. METHODS AND RESULTS: Participants with OH, defined as a decrease in blood pressure (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) from the supine to standing position, were identified during the first visit of the ARIC (Atherosclerosis Risk in Communities) Study (1987-1989) within 2 minutes of standing...
May 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29725320/cardiovascular-autonomic-neuropathy-and-glucose-variability-in-patients-with-type-1-diabetes-is-there-an-association
#10
Szabolcs Nyiraty, Fruzsina Pesei, Andrea Orosz, Sara Coluzzi, Orsolya Eszter Vági, Csaba Lengyel, György Ábrahám, Simona Frontoni, Peter Kempler, Tamás Várkonyi
Introduction: The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect GV. Patients and methods: Twenty type 1 diabetic patients were involved (age: 39.5 ± 3.4 years, duration of diabetes: 17.5 ± 2.5 years; HbA1c: 8...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29723581/the-nitric-oxide-guanylate-cyclase-pathway-and-glaucoma
#11
REVIEW
Lauren K Wareham, Emmanuel S Buys, Rebecca M Sappington
Glaucoma is a prevalent optic neuropathy characterized by the progressive dysfunction and loss of retinal ganglion cells (RGCs) and their optic nerve axons leading to irreversible visual field loss. Multiple risk factors for the disease have been identified, but elevated intraocular pressure (IOP) remains the primary risk factor amenable to treatment. Reducing IOP however does not always prevent glaucomatous neurodegeneration, and many patients progress with the disease despite having IOP in the normal range...
April 30, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29702978/optic-neuropathy-causing-vertical-unilateral-hemianopsia-after-pars-plana-vitrectomy-for-a-macular-hole-a-case-report
#12
Hirohiko Kawashima, Norihiro Nagai, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
INTRODUCTION: Recent progress in medical technology has resulted in improved surgical outcomes of pars plana vitrectomy (PPV); with microincision systems, the incidence of procedure-related complications during surgery has been reduced. However, unpredictable visual field defects after PPV remain an unresolved issue. A few reports have shown that damage to the retinal neurofibers owing to dry-up during air/fluid exchange or retinal neurotoxicity of the dye used to visualize the internal limiting membrane (ILM), as well as unintentional removal of retinal neurofibers during ILM peeling, are responsible for such visual field disorders...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29693021/predictors-of-cardiovascular-autonomic-neuropathy-onset-and-progression-in-a-cohort-of-type-1-diabetic-patients
#13
M Matta, A Pavy-Le Traon, S Perez-Lloret, C Laporte, I Berdugo, N Nasr, H Hanaire, J M Senard
Aim: The prevalence of cardiovascular autonomic neuropathy (CAN) in diabetes mellitus is well documented. However, the rate and predictors of both the development and progression of CAN have been less studied. Hereby, we assessed the rate and the major risk factors for CAN initiation and progression in a cohort of type 1 diabetic patients followed over a three-year period. Methods: 175 type 1 diabetic patients (mean age: 50 ± 11 years; female/male: 76/99) with positive bedside screening for CAN were included and underwent 2 standardized autonomic testings using 4 standardized tests (deep breathing, Valsalva maneuver, 30/15 ratio, and changes in blood pressure during standing), separated by 3 ± 1 years...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29675479/associations-of-diabetic-retinopathy-with-retinal-neurodegeneration-on-the-background-of-diabetes-mellitus-overview-of-recent-medical-studies-with-an-assessment-of-the-impact-on-healthcare-systems
#14
Rafał Muc, Agnieszka Saracen, Iwona Grabska-Liberek
Diabetes Mellitus (DM) is one of the biggest healthcare and financial problems worldwide. The disease is strongly associated with microvascular and macrovascular complications, causing co-existing diseases like Diabetic Retinopathy, Diabetic Neuropathy and Diabetic Nephropathy. Annual healthcare expenditures for diabetes treatment and complications prevention cost 727 billion USD in year 2017. Diabetes Mellitus, Diabetic Retinopathy and Diabetic Retinal Neuropathy are closely related diseases - originating from incorrectly controlled glycemia, blood pressure and lipid levels in the course of increasing resistance of the body tissues to insulin...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29670504/clozapine-induced-cardiovascular-side-effects-and-autonomic-dysfunction-a-systematic-review
#15
Jessica W Y Yuen, David D Kim, Ric M Procyshyn, Randall F White, William G Honer, Alasdair M Barr
Background: Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia and has minimal risk for extrapyramidal symptoms. Therapeutic benefits, however, are accompanied by a myriad of cardiometabolic side-effects. The specific reasons for clozapine's high propensity to cause adverse cardiometabolic events remain unknown, but it is believed that autonomic dysfunction may play a role in many of these. Objective: This systematic review summarizes the literature on autonomic dysfunction and related cardiovascular side effects associated with clozapine treatment...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29669555/the-role-of-dipeptidylpeptidase-4-inhibitors-in-management-of-cardiovascular-disease-in-diabetes-focus-on-linagliptin
#16
REVIEW
Annayya R Aroor, Camila Manrique-Acevedo, Vincent G DeMarco
Multiple population based analyses have demonstrated a high incidence of cardiovascular disease (CVD) and cardiovascular (CV) mortality in subjects with T2DM that reduces life expectancy by as much as 15 years. Importantly, the CV system is particularly sensitive to the metabolic and immune derangements present in obese pre-diabetic and diabetic individuals; consequently, CV dysfunction is often the initial CV derangement to occur and promotes the progression to end organ/tissue damage in T2DM. Specifically, diabetic CVD can manifest as microvascular complications, such as nephropathy, retinopathy, and neuropathy, as well as, macrovascular impairments, including ischemic heart disease, peripheral vascular disease, and cerebrovascular disease...
April 18, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29669327/effects-of-baicalin-on-diabetic-cardiac-autonomic-neuropathy-mediated-by-the-p2y12-receptor-in-rat-stellate-ganglia
#17
Xuan Sheng, Jiayue Wang, Jingjing Guo, Yurong Xu, Huaide Jiang, Chaoran Zheng, Zixi Xu, Yuanruohan Zhang, Hongyu Che, Shangdong Liang, Gaochun Zhu, Guilin Li
BACKGROUND/AIMS: Chronic diabetic hyperglycemia can damage various of organ systems and cause serious complications. Although diabetic cardiac autonomic neuropathy (DCAN) is the primary cause of death in diabetic patients, its pathogenesis remains to be fully elucidated. Baicalin is a flavonoid extracted from Scutellaria baicalensis root and has antibacterial, diuretic, anti-inflammatory, anti- metamorphotic, and antispasmodic effects. Our study explored the effects of baicalin on enhancing sympathoexcitatory response induced by DCAN via the P2Y12 receptor...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29657203/the-development-of-malnutrition-is-not-dependent-on-its-traditional-contributing-factors-in-patients-on-maintenance-hemodialysis-in-developing-countries
#18
Syed Rizwan Ali Bokhari, Mirza Ameer Faizan Ali, Syed Arsalan Khalid, Bushra Iftikhar, Hafiz Ijaz Ahmad, Ahlam Safdar Hussain, Usman Yaqoob
Malnutrition in dialysis population is associated with significant morbidity and mortality. Nutritional assessment is a neglected area in hemodialysis (HD) patients in developing countries. The aim of the study was to find out whether any traditional parameters have statistically significant correlation with malnutrition. All 58 end-stage renal disease patients on maintenance HD in our dialysis unit were enrolled in this cross-sectional study. The nutritional status was assessed by a predesigned questionnaire including subjective global assessment (SGA)...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29649995/the-prevalence-and-systemic-risk-factors-of-diabetic-macular-edema-a-cross-sectional-study-from-turkey
#19
Durgul Acan, Mehmet Calan, Duygu Er, Tugba Arkan, Nilufer Kocak, Firat Bayraktar, Suleyman Kaynak
BACKGROUND: The aim of this study was to evaluate the prevalence of diabetic macular edema (DME) utilizing optical coherence tomography (OCT), and to clarify the effects of the systemic findings and risk factors on the development of DME. METHODS: This cross-sectional study was conducted in the departments of ophthalmology and endocrinology at the Dokuz Eylul University School of Medicine in Izmir, Turkey. The demographics, type and duration of diabetes mellitus, treatment modality, smoking and alcohol consumption habits, as well as the systemic blood pressure, renal functional tests, hemoglobulin A1c level, serum lipid profile, and 24-h urine albumin level were noted and statistically analyzed...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29627803/danish-centre-for-strategic-research-in-type-2-diabetes-dd2-project-cohort-of-newly-diagnosed-patients-with-type-2-diabetes-a-cohort-profile
#20
Diana Hedevang Christensen, Sia Kromann Nicolaisen, Klára Berencsi, Henning Beck-Nielsen, Jørgen Rungby, Søren Friborg, Ivan Brandslund, Jens Sandahl Christiansen, Allan Vaag, Henrik Toft Sørensen, Jens Steen Nielsen, Reimar Wernich Thomsen
PURPOSE: The aim of this article is to provide a detailed description of the ongoing nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project cohort and biobank. The DD2 cohort continuously enrols newly diagnosed patients with type 2 diabetes (T2D) throughout Denmark. The overall goal of the DD2 project is to establish a large and data-rich T2D cohort that can serve as a platform for exhaustive T2D research including (1) improved genotypic and phenotypic characterisation of T2D, (2) intervention studies of more individualised T2D treatment, (3) pharmacoepidemiological studies and (4) long-term follow-up studies on predictors of T2D complications and prognosis...
April 7, 2018: BMJ Open
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