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JOURNAL ARTICLE
Parthiban Velayutham, Shivakumar Thiagarajan, Harsh Dhar, Nithyanad Chidambaranathan, Abhishek Vaidya, Kantamani Teja
UNLABELLED: There is still equipoise for the routine use of intraoperative nerve monitoring (IONM) for thyroid surgeries; however, some surgeons tend to use it for various reasons. In our study, we did a national survey to assess the patterns and practice of the use of IONM among surgeons during thyroid surgery in India. A questionnaire survey was sent to surgeons (head and neck surgical oncologists, general surgical oncologists, endocrine surgeons and otolaryngologists) in different zones in India via email, and their responses were analysed...
March 2024: Indian Journal of Surgical Oncology
#22
JOURNAL ARTICLE
Bridget Devaney
A proposal for a large, multi-centre, randomised controlled trial investigating the role of hyperbaric oxygen treatment (HBOT) in necrotising soft tissue infections (NSTI) has led to much discussion locally and internationally about whether participation is ethical for a centre where stakeholders already consider HBOT standard practice. This article systematically addresses the concept of clinical equipoise specific to the role of HBOT in NSTI, and presents a series of considerations to be taken into account by key stakeholders at potential participating sites...
March 31, 2024: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
#23
JOURNAL ARTICLE
Frances Varian, Jennifer Dick, Christian Battersby, Stefan Roman, Jenna Ablott, Lisa Watson, Sarah Binmahfooz, Hamza Zafar, Gerry Colgan, John Cannon, Jay Suntharalingam, Jim Lordan, Luke Howard, Colm McCabe, John Wort, Laura Price, Colin Church, Neil Hamilton, Iain Armstrong, Abdul Hameed, Judith Hurdman, Charlie Elliot, Robin Condliffe, Martin Wilkins, Alastair Webb, David Adlam, Ray L Benza, Kazem Rahimi, Mohadeseh Shojaei-Shahrokhabadi, Nan X Lin, James M S Wason, Alasdair McIntosh, Alex McConnachie, Jennifer T Middleton, Roger Thompson, David G Kiely, Mark Toshner, Alexander Rothman
Approved therapies for the treatment of patients with pulmonary arterial hypertension (PAH) mediate pulmonary vascular vasodilatation by targeting distinct biological pathways. International guidelines recommend that patients with an inadequate response to dual therapy with a phosphodiesterase type-5 inhibitor (PDE5i) and endothelin receptor antagonist (ERA), are recommended to either intensify oral therapy by adding a selective prostacyclin receptor (IP) agonist (selexipag), or switching from PDE5i to a soluble guanylate-cyclase stimulator (sGCS; riociguat)...
January 2024: Pulmonary Circulation
#24
JOURNAL ARTICLE
Ary Serpa Neto, Rinaldo Bellomo
No abstract text is available yet for this article.
March 18, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
#25
JOURNAL ARTICLE
Tito Fojo, Meredith LaRose, Susan E Bates
No abstract text is available yet for this article.
March 18, 2024: Oncologist
#26
JOURNAL ARTICLE
M F Bath, J Schloer, J Strobel, W Rea, R Lefering, M Maegele, H De'Ath, Z B Perkins
INTRODUCTION: Fluid resuscitation has long been a cornerstone of pre-hospital trauma care, yet its optimal approach remains undetermined. Although a liberal approach to fluid resuscitation has been linked with increased complications, the potential survival benefits of a restrictive approach in blunt trauma patients have not been definitively established. Consequently, equipoise persists regarding the optimal fluid resuscitation strategy in this population. METHODS: We analysed data from the two largest European trauma registries, the UK Trauma Audit and Research Network (TARN) and the German TraumaRegister DGU® (TR-DGU), between 2004 and 2018...
March 15, 2024: Critical Care: the Official Journal of the Critical Care Forum
#27
REVIEW
Jannicke Rabben, Bella Vivat, Mariann Fossum, Gudrun Elin Rohde
BACKGROUND: Shared decision-making is a key element of person-centred care and promoted as the favoured model in preference-sensitive decision-making. Limitations to implementation have been observed, and barriers and limitations, both generally and in the palliative setting, have been highlighted. More knowledge about the process of shared decision-making in palliative cancer care would assist in addressing these limitations. AIM: To identify and synthesise qualitative data on how people with cancer, informal carers and healthcare professionals experience and perceive shared decision-making in palliative cancer care...
March 13, 2024: Palliative Medicine
#28
JOURNAL ARTICLE
Christopher A Guidry, Lynn Chollet-Hinton, Jordan Baker, Jacob C O'Dell, Robel T Beyene, Christopher M Watson, Robert G Sawyer, Steven Q Simpson, Leanne Atchison, Michael Derickson, Lindsey C Cooper, G Patton Pennington Ii, Sheri VandenBerg, Bachar N Halimeh
Background: Pneumonia is the most common intensive care unit (ICU)-acquired infection and source of potential sepsis in ICU populations but can be difficult to diagnose in real-time. Despite limited data, rapid initiation of antibiotic agents is endorsed by society guidelines. We hypothesized that a post hoc analysis of a recent randomized pilot study would show no difference between two antibiotic initiation strategies. Patients and Methods: The recent Trial of Antibiotic Restraint in Presumed Pneumonia (TARPP) was a pragmatic cluster-randomized pilot of antibiotic initiation strategies for patients with suspected ICU-acquired pneumonia...
March 7, 2024: Surgical Infections
#29
REVIEW
Enda Murphy, Francis Martin Finucane
We are at the start of an exciting new era of very effective pharmacotherapy for patients with obesity, with the latest generation of drugs approaching the efficacy of obesity surgery. Clinical trials of obesity drugs tend to emphasise the importance of participation in some form of structured lifestyle intervention for all trial participants. This usually consists of advice to reduce calorie intake and increase moderate to vigorous physical activity. There is strong evidence that structured lifestyle modification programmes improve health in patients with obesity and related disorders...
March 8, 2024: International Journal of Obesity
#30
JOURNAL ARTICLE
Bryn O Zomar, Maio Chen, Emily K Schaeffer, Kishore Mulpuri, Alexander Joeris
INTRODUCTION: Management controversy and clinical equipoise exist in treatments of long bone fractures and traumatic hip dislocation in paediatric patients due to the lack of high-quality clinical evidence. This protocol describes the effort of a large prospective global multicentre cohort study (registry) aiming at providing quality data to assist evidence-based treatment decision-making. METHODS AND ANALYSIS: Eligible paediatric patients (N=750-1000) with open physes suffering from proximal humerus fractures, distal humerus fractures, proximal radius fractures, forearm shaft fractures, traumatic hip dislocations, femoral neck fractures or tibial shaft fractures will be recruited over a period of 24-36 months...
March 8, 2024: BMJ Open
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JOURNAL ARTICLE
Taryn N Walker, Jennifer C Urquhart, Parham Rasoulinejad, Supriya Singh, R Andrew Glennie, Charles G Fisher, Y Raja Rampersaud, Edward Abraham, John Street, Marcel F Dvorak, Scott Paquette, Raphaele Charest-Morin, Nicolas Dea, Nicholas Gelinas-Phaneuf, Brian K Kwon, Christopher S Bailey
OBJECTIVE: Surgical treatment of degenerative lumbar spondylolisthesis (DLS) reliably improves patient-reported quality of life; however, patient population heterogeneity, in addition to other factors, ensures ongoing equipoise in choosing the ideal surgical treatment. Surgeon preference for fusion or decompression alone influences surgical treatment decision-making. Meanwhile, at presentation, patient-reported outcome measures (PROMs) differ considerably between females and males. The aims of this study were to determine whether there exists a difference in the rates of decompression and fusion versus decompression alone based on patient-reported sex, and to determine if widely accepted indications for fusion justify any observed differences or if surgeon preference plays a role...
March 8, 2024: Journal of Neurosurgery. Spine
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JOURNAL ARTICLE
Eleanor Molloy, Nicole Pilarski, Katie Morris, Victoria Hodgetts-Morton, Laura Jones
OBJECTIVES: The embedded Qualitative Process Evaluation (QPE) within the CSTICH- Pilot RCT explored facilitators and barriers to recruitment within the Pilot. This study reports a secondary analysis of the overarching theme of Fluidity of Equipoise and the influences on individual and community clinical equipoise around the use of Emergency Cervical Cerclage (ECC). STUDY DESIGN: RCT recruitment assumes clinical equipoise and is defined as genuine uncertainty about an intervention...
March 3, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#33
EDITORIAL
John R Miller
Management of patients with FAI and moderate (Tönnis grade 2) osteoarthritis remains a debated topic. Outcomes demonstrate that such patients can benefit from hip arthroscopy, yet the improvement may not be as favorable as desired. While certain factors, such as Tönnis grade 3 hip OA, older age, higher BMI, bipolar cartilage defects, and joint space less than 2mm may influence surgeons to avoid arthroscopic treatments, the threshold for grade 2 OA is not as clear. Moreover, while radiographs may appear similar in Tönnis 2, there may be a wide range of chondral damage seen arthroscopically...
February 28, 2024: Arthroscopy
#34
JOURNAL ARTICLE
Catherine A Chapin, James E Squires, Simon P Horslen, Estella M Alonso
No abstract text is available yet for this article.
February 26, 2024: Journal of Pediatric Gastroenterology and Nutrition
#35
REVIEW
Tejan Baldeh, Tomás Reilly, Tayyaub Mansoor, Gerard Feeney, Mekki Medani, Michael A Moloney, Eamon G Kavanagh
OBJECTIVES: Comparative effectiveness of fenestrated endovascular aneurysm repair (FEVAR) and chimney graft endovascular aneurysm repair (ChEVAR) for juxtarenal aortic aneurysms (JAAs) remains unclear. Our objective was to identify and analyze the current body of evidence comparing the effectiveness of both techniques for JAA. METHODS: We performed a systematic review and meta-analysis comparing the effectiveness of FEVAR and ChEVAR for JAA repair. We searched MEDLINE, EMBASE, and Cochrane Register for Controlled Trials from January 1, 1990, for randomized and non-randomized studies assessing outcomes of FEVAR and ChEVAR for JAA repair...
February 22, 2024: Journal of Endovascular Therapy
#36
JOURNAL ARTICLE
Kelly J Norsworthy, Rosa J Lee-Alonzo, Richard Pazdur
No abstract text is available yet for this article.
February 21, 2024: Nature Reviews. Clinical Oncology
#37
JOURNAL ARTICLE
Ryan Ruiyang Ling, Christopher Jer Wei Low, Kollengode Ramanathan
No abstract text is available yet for this article.
March 1, 2024: Critical Care Medicine
#38
Rohan Khera, Arya Aminorroaya, Lovedeep Singh Dhingra, Phyllis M Thangaraj, Aline Pedroso Camargos, Fan Bu, Xiyu Ding, Akihiko Nishimura, Tara V Anand, Faaizah Arshad, Clair Blacketer, Yi Chai, Shounak Chattopadhyay, Michael Cook, David A Dorr, Talita Duarte-Salles, Scott L DuVall, Thomas Falconer, Tina E French, Elizabeth E Hanchrow, Guneet Kaur, Wallis Cy Lau, Jing Li, Kelly Li, Yuntian Liu, Yuan Lu, Kenneth Kc Man, Michael E Matheny, Nestoras Mathioudakis, Jody-Ann McLeggon, Michael F McLemore, Evan Minty, Daniel R Morales, Paul Nagy, Anna Ostropolets, Andrea Pistillo, Thanh-Phuc Phan, Nicole Pratt, Carlen Reyes, Lauren Richter, Joseph Ross, Elise Ruan, Sarah L Seager, Katherine R Simon, Benjamin Viernes, Jianxiao Yang, Can Yin, Seng Chan You, Jin J Zhou, Patrick B Ryan, Martijn J Schuemie, Harlan M Krumholz, George Hripcsak, Marc A Suchard
BACKGROUND: SGLT2 inhibitors (SGLT2is) and GLP-1 receptor agonists (GLP1-RAs) reduce major adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus (T2DM). However, their effectiveness relative to each other and other second-line antihyperglycemic agents is unknown, without any major ongoing head-to-head trials. METHODS: Across the LEGEND-T2DM network, we included ten federated international data sources, spanning 1992-2021. We identified 1,492,855 patients with T2DM and established cardiovascular disease (CVD) on metformin monotherapy who initiated one of four second-line agents (SGLT2is, GLP1-RAs, dipeptidyl peptidase 4 inhibitor [DPP4is], sulfonylureas [SUs])...
February 8, 2024: medRxiv
#39
EDITORIAL
Peter J Neuburger, Sandeep Krishnan, Kinjal M Patel
No abstract text is available yet for this article.
January 27, 2024: Journal of Cardiothoracic and Vascular Anesthesia
#40
REVIEW
A Noureldin, V Ivankovic, M Delisle, T F Wang, R C Auer, M Carrier
Major abdominopelvic surgery is an important risk factor for postoperative venous thromboembolism (VTE). VTE is the leading cause of 30-day postoperative mortality in patients with cancer undergoing major abdominopelvic surgery. Randomized controlled trials have shown that extended duration thromboprophylaxis using a low molecular weight heparin or a direct oral anticoagulant significantly decreases the risk of overall VTE (symptomatic events and asymptomatic deep vein thrombosis). Hence, several clinical practice guidelines suggest the use of extended duration thromboprophylaxis for all high-risk patients undergoing major abdominopelvic surgery...
February 4, 2024: Thrombosis Research
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