Ana Zilda Nazar Bergamo, Isabela Ribeiro Madalena, Marjorie Ayumi Omori, Lucas Alexandre Ramazzotto, Paulo Nelson-Filho, Flares Baratto-Filho, Peter Proff, Christian Kirschneck, Erika Calvano Küchler
BACKGROUND: The aim of this study was investigated if estrogen deficiency during puberty affects the expression of miRNA30a and miRNA503 in maxillary and mandibular growth centers, and also evaluated if ERα and ERβ are correlated with miRNA30a and miRNA503 expressions. METHODS: Samples from 12 female Wistar rats randomized into experimental group (OVX) and control group (SHAM). At an age of 45 days animals were euthanized for miRNA expression analyses. RT-qPCR was performed to determine miRNA30a and miRNA503 expression in growth sites: midpalatal suture, condyle, mandibular angle, symphysis/parasymphysis and coronoid process...
February 2022: Annals of Anatomy