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https://www.readbyqxmd.com/read/28222194/forecasting-outpatient-visits-using-empirical-mode-decomposition-coupled-with-back-propagation-artificial-neural-networks-optimized-by-particle-swarm-optimization
#1
Daizheng Huang, Zhihui Wu
Accurately predicting the trend of outpatient visits by mathematical modeling can help policy makers manage hospitals effectively, reasonably organize schedules for human resources and finances, and appropriately distribute hospital material resources. In this study, a hybrid method based on empirical mode decomposition and back-propagation artificial neural networks optimized by particle swarm optimization is developed to forecast outpatient visits on the basis of monthly numbers. The data outpatient visits are retrieved from January 2005 to December 2013 and first obtained as the original time series...
2017: PloS One
https://www.readbyqxmd.com/read/28222116/the-role-of-short-term-memory-and-visuo-spatial-skills-in-numerical-magnitude-processing-evidence-from-turner-syndrome
#2
Lucie Attout, Marie-Pascale Noël, Marie-Cécile Nassogne, Laurence Rousselle
Most studies on magnitude representation have focused on the visual modality with no possibility of disentangling the influence of visuo-spatial skills and short-term memory (STM) abilities on quantification processes. This study examines this issue in patients with Turner syndrome (TS), a genetic condition characterized by a specific cognitive profile frequently associating poor mathematical achievement, low spatial skills and reduced STM abilities. In order to identify the influence of visuo-spatial and STM processing on numerical magnitude abilities, twenty female participants with TS and twenty control female participants matched for verbal IQ and education level were administered a series of magnitude comparison tasks...
2017: PloS One
https://www.readbyqxmd.com/read/28221999/coupling-effect-of-double-lungs-on-a-vcv-ventilator-with-automatic-secretion-clearance-function
#3
Yan Shi, Bolun Zhang, Maolin Cai, Weiqing Xu
For patients with mechanical ventilation, secretions in airway are harmful and sometimes even mortal, it's of great significance to clear secretion timely and efficiently. In this paper, a new secretion clearance method for VCV (volume-controlled ventilation) ventilator is put forward, and a secretion clearance system with a VCV ventilator and double lungs is designed. Furthermore, the mathematical model of the secretion clearance system is built and verified via experimental study. Finally, to illustrate the influence of key parameters of respiratory system and secretion clearance system on the secretion clearance characteristics, coupling effects of two lungs on VCV secretion clearance system are studied by an orthogonal experiment, it can be obtained that rise of tidal volume adds to efficiency of secretion clearance while effect of area, compliance and suction pressure on efficiency of secretion clearance needs further study...
February 16, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28221933/thermal-inactivation-kinetics-of-sporolactobacillus-nakayamae-spores-a-spoilage-bacterium-isolated-from-a-model-mashed-potato-scallion-mixture
#4
Hayriye Bozkurt, Jairus R D David, Ryan J Talley, D Scott Lineback, P Michael Davidson
Sporolactobacillus species have been occasionally isolated from spoiled foods and environmental sources. Thus, food processors should be aware of their potential presence and characteristics. In this study, the heat resistance and influence of the growth and recovery media on apparent heat resistance of Sporolactobacillus nakayamae spores were studied and described mathematically. For each medium, survivor curves and thermal death curves were generated for different treatment times (0 to 25 min) at different temperatures (70, 75, and 80°C) and Weibull and first-order models were compared...
September 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28220830/the-genetic-and-environmental-aetiology-of-spatial-mathematics-and-general-anxiety
#5
Margherita Malanchini, Kaili Rimfeld, Nicholas G Shakeshaft, Maja Rodic, Kerry Schofield, Saskia Selzam, Philip S Dale, Stephen A Petrill, Yulia Kovas
Individuals differ in their level of general anxiety as well as in their level of anxiety towards specific activities, such as mathematics and spatial tasks. Both specific anxieties correlate moderately with general anxiety, but the aetiology of their association remains unexplored. Moreover, the factor structure of spatial anxiety is to date unknown. The present study investigated the factor structure of spatial anxiety, its aetiology, and the origins of its association with general and mathematics anxiety in a sample of 1,464 19-21-year-old twin pairs from the UK representative Twins Early Development Study...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220440/quantum-probability-ranking-principle-for-ligand-based-virtual-screening
#6
Mohammed Mumtaz Al-Dabbagh, Naomie Salim, Mubarak Himmat, Ali Ahmed, Faisal Saeed
Chemical libraries contain thousands of compounds that need screening, which increases the need for computational methods that can rank or prioritize compounds. The tools of virtual screening are widely exploited to enhance the cost effectiveness of lead drug discovery programs by ranking chemical compounds databases in decreasing probability of biological activity based upon probability ranking principle (PRP). In this paper, we developed a novel ranking approach for molecular compounds inspired by quantum mechanics, called quantum probability ranking principle (QPRP)...
February 20, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28220320/a-novel-method-for-non-invasively-detecting-the-severity-and-location-of-aortic-aneurysms
#7
Igor Sazonov, Ashraf W Khir, Wisam S Hacham, Etienne Boileau, Jason M Carson, Raoul van Loon, Colin Ferguson, Perumal Nithiarasu
The influence of an aortic aneurysm on blood flow waveforms is well established, but how to exploit this link for diagnostic purposes still remains challenging. This work uses a combination of experimental and computational modelling to study how aneurysms of various size affect the waveforms. Experimental studies are carried out on fusiform-type aneurysm models, and a comparison of results with those from a one-dimensional fluid-structure interaction model shows close agreement. Further mathematical analysis of these results allows the definition of several indicators that characterize the impact of an aneurysm on waveforms...
February 21, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28220205/global-properties-of-nested-network-model-with-application-to-multi-epitope-hiv-ctl-dynamics
#8
Cameron Browne
Mathematical modeling and analysis can provide insight on the dynamics of ecosystems which maintain biodiversity in the face of competitive and prey-predator interactions. Of primary interests are the underlying structure and features which stabilize diverse ecological networks. Recently Korytowski and Smith (Theor Ecol 8(1):111-120, 2015) proved that a perfectly nested infection network, along with appropriate life history trade-offs, leads to coexistence and persistence of bacteria-phage communities in a chemostat model...
February 20, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28220104/systems-biology-derived-discoveries-of-intrinsic-clocks
#9
REVIEW
Arthur Millius, Hiroki R Ueda
A systems approach to studying biology uses a variety of mathematical, computational, and engineering tools to holistically understand and model properties of cells, tissues, and organisms. Building from early biochemical, genetic, and physiological studies, systems biology became established through the development of genome-wide methods, high-throughput procedures, modern computational processing power, and bioinformatics. Here, we highlight a variety of systems approaches to the study of biological rhythms that occur with a 24-h period-circadian rhythms...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28220102/a-nuanced-look-at-women-in-stem-fields-at-two-year-colleges-factors-that-shape-female-students-transfer-intent
#10
Xueli Wang, Hsun-Yu Chan, Sara Jimenez Soffa, Brett Ranon Nachman
In this study, we explored the relationship between the intent to transfer upward and a set of motivational, contextual, and socio-demographic background factors among 696 female students beginning in science, technology, engineering, and mathematics (STEM) programs or courses at two-year colleges in a Midwestern state. Drawing upon survey data and administrative records, our multinomial logistic regression analysis revealed that students' math and science self-efficacy beliefs, as well as transfer-oriented interaction, were significant and positive predictors for their intent to transfer into STEM fields as opposed to having no intent to transfer...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28220053/simulation-study-on-effects-of-order-and-step-size-of-runge-kutta-methods-that-solve-contagious-disease-and-tumor-models
#11
Wang Z, Wang Q, Klinke Dj
Biological processes such as contagious disease spread patterns and tumor growth dynamics are modelled using a set of coupled differential equations. Experimental data is usually used to calibrate models so they can be used to make future predictions. In this study, numerical methods were implemented to approximate solutions to mathematical models that were not solvable analytically, such as a SARS model. More complex models such as a tumor growth model involve high-dimensional parameter spaces; efficient numerical simulation techniques were used to search for optimal or close-to-optimal parameter values in the equations...
September 2016: Journal of Computer Science and Systems Biology
https://www.readbyqxmd.com/read/28219946/distinct-intracellular-ca-2-dynamics-regulate-apical-constriction-and-differentially-contribute-to-neural-tube-closure
#12
Makoto Suzuki, Masanao Sato, Hiroshi Koyama, Yusuke Hara, Kentaro Hayashi, Naoko Yasue, Hiromi Imamura, Toshihiko Fujimori, Takeharu Nagai, Robert E Campbell, Naoto Ueno
Early in the development of the central nervous system, progenitor cells undergo a shape change, called apical constriction, that triggers the neural plate to form a tubular structure. How apical constriction in the neural plate is controlled, and contributes to tissue morphogenesis, are not fully understood. In this study, we show that intracellular calcium ions (Ca(2+)) are required for Xenopus neural tube formation, and that there are two types of Ca(2+)-concentration changes, a single-cell and a multicellular wave-like fluctuation, in the developing neural plate...
February 20, 2017: Development
https://www.readbyqxmd.com/read/28219833/statistical-appearance-models-based-on-probabilistic-correspondences
#13
Julia Krüger, Jan Ehrhardt, Heinz Handels
Model-based image analysis is indispensable in medical image processing. One key aspect of building statistical shape and appearance models is the determination of one-to-one correspondences in the training data set. At the same time, the identification of these correspondences is the most challenging part of such methods. In our earlier work, we developed an alternative method using correspondence probabilities instead of exact one-to-one correspondences for a statistical shape model (Hufnagel et al., 2008)...
February 7, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28219660/modelling-and-investigation-of-the-cd4-t-cells-macrophages-paradox-in-melanoma-immunotherapies
#14
Raluca Eftimie, Haneen Hamam
It is generally accepted that tumour cells can be eliminated by M1 anti-tumour macrophages and CD8(+) T cells. However, experimental results over the past 10-15 years have shown that B16 mouse melanoma cells can be eliminated by the CD4(+) T cells alone (either Th1 or Th2 sub-types), in the absence of CD8(+) T cells. In some studies, elimination of B16 melanoma was associated with a Th1 immune response (i.e., elimination occurred in the presence of cytokines produced by Th1 cells), while in other studies melanoma elimination was associated with a Th2 immune response (i...
February 17, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28219373/a-new-efficient-approach-to-fit-stochastic-models-on-the-basis-of-high-throughput-experimental-data-using-a-model-of-irf7-gene-expression-as-case-study
#15
Luis U Aguilera, Christoph Zimmer, Ursula Kummer
BACKGROUND: Mathematical models are used to gain an integrative understanding of biochemical processes and networks. Commonly the models are based on deterministic ordinary differential equations. When molecular counts are low, stochastic formalisms like Monte Carlo simulations are more appropriate and well established. However, compared to the wealth of computational methods used to fit and analyze deterministic models, there is only little available to quantify the exactness of the fit of stochastic models compared to experimental data or to analyze different aspects of the modeling results...
February 20, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28219019/inferring-physiological-energetics-of-loggerhead-turtle-caretta-caretta-from-existing-data-using-a-general-metabolic-theory
#16
Nina Marn, S A L M Kooijman, Marko Jusup, Tarzan Legović, Tin Klanjšček
Loggerhead turtle is an endangered sea turtle species with a migratory lifestyle and worldwide distribution, experiencing markedly different habitats throughout its lifetime. Environmental conditions, especially food availability and temperature, constrain the acquisition and the use of available energy, thus affecting physiological processes such as growth, maturation, and reproduction. These physiological processes at the population level determine survival, fecundity, and ultimately the population growth rate-a key indicator of the success of conservation efforts...
February 3, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28218913/ligand-promoted-protein-folding-by-biased-kinetic-partitioning
#17
Karan S Hingorani, Matthew C Metcalf, Derrick T Deming, Scott C Garman, Evan T Powers, Lila M Gierasch
Protein folding in cells occurs in the presence of high concentrations of endogenous binding partners, and exogenous binding partners have been exploited as pharmacological chaperones. A combined mathematical modeling and experimental approach shows that a ligand improves the folding of a destabilized protein by biasing the kinetic partitioning between folding and alternative fates (aggregation or degradation). Computationally predicted inhibition of test protein aggregation and degradation as a function of ligand concentration are validated by experiments in two disparate cellular systems...
February 20, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28218842/medium-chain-chlorinated-paraffins-cps-dominate-in-australian-sewage-sludge
#18
Sicco Hendrik Brandsma, Louise van Mourik, Jake William O'Brien, Geoff Eaglesham, Pim E G Leonards, Jacob De Boer, Christie Gallen, Jochen F Mueller, Caroline Gaus, Christian Bogdal
To simultaneously quantify and profile the complex mixture of short-, median-, and long-chain CPs (SCCPs, MCCPs and LCCPs) in Australian sewage sludge, we applied and further validated a recently developed novel instrumental technique, using quadrupole time-of-flight high resolution mass spectrometry running in the negative atmospheric pressure chemical ionization mode (APCI-qTOF-HRMS). Without using an analytical column the cleaned extracts were directly injected into the qTOF-HRMS followed by quantification of the CPs by a mathematical algorithm...
February 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28218642/theoretical-analysis-of-an-optical-accelerometer-based-on-resonant-optical-tunneling-effect
#19
Aoqun Jian, Chongguang Wei, Lifang Guo, Jie Hu, Jun Tang, Jun Liu, Xuming Zhang, Shengbo Sang
Acceleration is a significant parameter for monitoring the status of a given objects. This paper presents a novel linear acceleration sensor that functions via a unique physical mechanism, the resonant optical tunneling effect (ROTE). The accelerometer consists of a fixed frame, two elastic cantilevers, and a major cylindrical mass comprised of a resonant cavity that is separated by two air tunneling gaps in the middle. The performance of the proposed sensor was analyzed with a simplified mathematical model, and simulated using finite element modeling...
February 17, 2017: Sensors
https://www.readbyqxmd.com/read/28218279/multi-constituent-simulation-of-thrombus-deposition
#20
Wei-Tao Wu, Megan A Jamiolkowski, William R Wagner, Nadine Aubry, Mehrdad Massoudi, James F Antaki
In this paper, we present a spatio-temporal mathematical model for simulating the formation and growth of a thrombus. Blood is treated as a multi-constituent mixture comprised of a linear fluid phase and a thrombus (solid) phase. The transport and reactions of 10 chemical and biological species are incorporated using a system of coupled convection-reaction-diffusion (CRD) equations to represent three processes in thrombus formation: initiation, propagation and stabilization. Computational fluid dynamic (CFD) simulations using the libraries of OpenFOAM were performed for two illustrative benchmark problems: in vivo thrombus growth in an injured blood vessel and in vitro thrombus deposition in micro-channels (1...
February 20, 2017: Scientific Reports
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