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https://www.readbyqxmd.com/read/28921409/the-duality-of-economic-issues-with-medication-non-adherence-in-patients-with-inflammatory-arthritis
#1
REVIEW
Natasha K J Campbell, Khalid Saadeldin, Mary A De Vera
PURPOSE OF REVIEW: In this review, we synthesize current data on non-adherence across inflammatory arthritides and explore (1) the effects of economic factors on non-adherence and (2) the impacts of non-adherence on economic outcomes. RECENT FINDINGS: Recent evidence demonstrates medication non-adherence rates as high as 74% in ankylosing spondylitis (AS), 90% in gout, 50% in psoriatic arthritis (PsA), 75% in systemic lupus erythematosus (SLE), and 82% in rheumatoid arthritis (RA)...
September 18, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28920498/an-update-on-biomarker-discovery-and-use-in-axial-spondyloarthritis
#2
Walter P Maksymowych
Evaluation of diagnosis, disease activity, and risk for joint damage all represent important unmet clinical needs in the management of axial spondyloarthritis that have been explored using biomarkers. Areas Covered: This review used the search terms biomarkers, ankylosing spondylitis, spondyloarthritis, spondyloarthropathy, pathogenesis, genetics, diagnostic tools, prognosis, to explore advances in biomarker development relevant to unmet clinical needs. Expert Commentary: Despite major advances in the identification of genetic risk markers, HLA-B*27 remains the only marker with clinical utility for diagnostic purposes...
September 16, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28918450/clinical-utility-of-the-asdas-index-in-comparison-with-basdai-in-patients-with-ankylosing-spondylitis-axis-study
#3
Agustí Sellas I Fernandez, Xavier Juanola Roura, Alberto Alonso Ruiz, José Rosas, Julio Medina Luezas, Eduardo Collantes Estevez, Miguel Ángel Abad Hernández, Virginia Carrasco Benitez, Cesar Fisac
The objective of the study was to study the clinical utility of the Ankylosing Spondylitis Disease Activity Score (ASDAS) for the assessment of disease activity in ankylosing spondylitis (AS) patients, compared to the Bath Ankylosing Spondylitis Activity Index (BASDAI). This was a prospective longitudinal observational study in patients with AS (NY-modified criteria) from 23 Spanish centers. Physical and analytical data; global, lumbar, and nocturnal pain; ASDAS, BASDAI and minimally acceptable clinical status (PASS) were collected...
September 16, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28914372/the-role-of-gut-microbiota-in-the-pathogenesis-of-rheumatic-diseases
#4
Danli Zhong, Chanyuan Wu, Xiaofeng Zeng, Qian Wang
Rheumatic diseases refer to many diseases with a loss of immune self-tolerance, leading to a chronic inflammation, degeneration, or metabolic derangement in multiple organs or tissues. The cause of rheumatic diseases remains to be elucidated, though both environmental and genetic factors are required for the development of rheumatic diseases. Over the past decades, emerging studies suggested that alteration of intestinal microbiota, known as gut dysbiosis, contributed to the occurrence or development of a range of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, systemic sclerosis, and Sjogren's syndrome, through profoundly affecting the balance between pro- and anti-inflammatory immune responses...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28914369/joint-involvement-in-mexican-patients-with-ulcerative-colitis-a-hospital-based-retrospective-study
#5
Jesús K Yamamoto-Furusho, Andrea Sarmiento-Aguilar
The most frequent extra-intestinal manifestation in ulcerative colitis (UC) around the world is joint involvement. There are no previous data in Latin America that is about this aspect of disease; hence, the aim of this study was to determine the frequency and factors associated to joint involvement in Mexican patients with UC. A total of 295 patients with histological diagnosis of UC were studied, divided into two groups: (1) 154 cases with at least one joint affection (arthralgia, peripheral, or axial arthropathy (sacroilitis (SI) or ankylosing spondylitis (AS))) and (2) 141 controls that had never presented any joint involvement during the clinical course of UC...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28914101/pelvic-incidence-and-hip-disorders
#6
Mikhail Saltychev, Katri Pernaa, Matti Seppänen, Keijo Mäkelä, Katri Laimi
Background and purpose - The role of pelvic incidence in hip disorders is unclear. Therefore, we undertook a literature review to evaluate the evidence on that role. Methods - A search was carried out on MEDLINE, SCOPUS, CENTRAL, and CINAHL databases. Quantitative analysis was based on comparison with a reference population of asymptomatic subjects. Results - The search resulted in 326 records: 15 studies were analyzed qualitatively and 13 quantitatively. The estimates of pelvic incidence varied more than 10 degrees from 47 (SD 3...
September 15, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28912853/efficacy-research-of-salazosulfamide-in-ankylosing-spondylitis-and-nat1-gene-polymorphism
#7
Xiu-Fen Ma, Xiao-Dong Wang, Run-Rong Liu, Qing-Xia Luan
The aim of this study was to explore the correlation of salazosulfamide efficacy on ankylosing spondylitis and N-acetyltransferase 1 (NAT1) gene polymorphism. Thirty-two patients with ankylosing spondylitis were recruited in the experimental group and 36 normal individuals were recruited to the control group. The experimental group received 8.0 mg of salazosulfamide (MTX) per week and the control group received isodose of normal saline. Twenty-six patients in the experimental group responded to the salazosulfamide treatment and 6 did not show response...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912774/therapeutic-antibodies-to-kir3dl2-and-other-target-antigens-on-cutaneous-t-cell-lymphomas
#8
REVIEW
Christian Schmitt, Anne Marie-Cardine, Armand Bensussan
KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linked homodimer. Each chain is composed of three immunoglobulin-like domains and a long cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs. Beside its expression on NK cells, it is also found on rare circulating T lymphocytes, mainly CD8(+). Although the KIR gene number varies between haplotype, KIR3DL2 is a framework gene present in all individuals...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28910361/fever-as-an-initial-manifestation-of-spondyloarthritis-a-retrospective-study
#9
Se Jin Byun, William Han Bae, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
OBJECTIVES: We aimed to evaluate a wide spectrum of clinical features of adult patients with spondyloarthritis (SpA) whose initial manifestation was fever, using the Assessment of SpondyloArthritis international Society (ASAS) classification criteria. METHODS: We retrospectively collected the electronic medical records of hospitalized SpA patients who initially presented to the Severance Hospital (Seoul, Korea) with fever from January 2010 to May 2016. As a control group, we also recruited one-hundred consecutive patients who were diagnosed with SpA in our outpatient clinic...
2017: PloS One
https://www.readbyqxmd.com/read/28901420/bioinformatics-analysis-of-genetic-variants-of-endoplasmic-reticulum-aminopeptidase-1-in-ankylosing-spondylitis
#10
Xiaoli Wang, Jie Ma, Jianbing Ma, Yurong Wen, Liesu Meng, Hao Yang, Rui Zhang, Dingjun Hao
According to the results of the first genome-wide association study of ankylosing spondylitis (AS), endoplasmic reticulum aminopeptidase 1 (ERAP1) may serve an important role. However, a number of case-control studies have not been able to replicate this result using the same genetic markers. In the present study, the role of common genetic variants of ERAP1 in AS was investigated using two-stage bioinformatics analysis. In the first stage, a classical meta-analysis was performed to assess AS susceptibility markers in ERAP1 using data from available published case-control association studies...
August 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28901023/mosasaurs-and-snakes-have-a-periodontal-ligament-timing-and-extent-of-calcification-not-tissue-complexity-determines-tooth-attachment-mode-in%C3%A2-reptiles
#11
Aaron R H LeBlanc, Denis O Lamoureux, Michael W Caldwell
Squamates present a unique challenge to our understanding of dental evolution in amniotes because they are the only extant tooth-bearing group for which a ligamentous tooth attachment is considered to be absent. This has led to the assumption that mammals and crocodilians have convergently evolved a ligamentous tooth attachment, composed of root cementum, periodontal ligament, and alveolar bone, whereas squamates are thought to possess a single bone of attachment tissue that fuses teeth to the jaws. The identity and homology of tooth attachment tissues between squamates, crocodilians, and mammals have thus been a focal point of debate for decades...
September 12, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28898393/is-beh%C3%A3-et-s-disease-a-class-1-opathy-the-role-of-hla-b-51-in-the-pathogenesis-of-beh%C3%A3-et-s-disease
#12
REVIEW
Mark Giza, Danai Koftori, Liye Chen, Paul Bowness
The association between carriage of the HLA-B*51 allele and development of Behçet's Disease (BD) has been known since the early 1970s, but the exact mechanisms responsible for its role in pathogenesis remain much-debated. In an effort to explain the disease process, it has been suggested that BD constitutes one of a newly-termed group of diseases, the 'MHC-I-opathies'. Other MHC-I-opathies' include Ankylosing Spondylitis and other HLA-B*27-associated spondyloarthropathies, and HLA-C*0602-associated skin psoriasis...
September 12, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28894079/portuguese-recommendations-for-the-use-of-biological-therapies-in-patients-with-axial-spondyloarthritis-2016-update
#13
Pedro Machado, Marcos Cerqueira, Pedro Ávila-Ribeiro, Renata Aguiar, Alexandra Bernardo, Alexandre Sepriano, Ana Águeda, Ana Cordeiro, Ana Raposo, Ana M Rodrigues, Anabela Barcelos, Armando Malcata, Carina Lopes, Cláudia Vaz, Dolores Nour, Fátima Godinho, Fernando Alvarenga, Fernando Pimentel-Santos, Helena Canhão, Helena Santos, Inês Cunha, Joana Sousa Neves, João Eurico Fonseca, João Lagoas Gomes, José Tavares-Costa, Lúcia Costa, Luís Cunha-Miranda, Luís Maurício, Margarida Cruz, Maria Carmo Afonso, Maria José Santos, Miguel Bernardes, Paula Valente, Ricardo Figueira, Sofia Pimenta, Sofia Ramiro, Teresa Pedrosa, Tiago Afonso Costa, Elsa Vieira-Sousa
OBJECTIVE: To update the recommendations for the treatment of axial spondyloarthritis (axSpA) with biological therapies, endorsed by the Portuguese Society of Rheumatology. METHODS: These treatment recommendations were formulated by Portuguese rheumatologists based on literature evidence and consensus opinion. At a national meeting, the 7 recommendations included in this document were discussed and updated. A draft of the full text of the recommendations was then circulated and suggestions were incorporated...
June 25, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28891005/evaluation-of-the-internal-oblique-external-oblique-and-transversus-abdominalis-muscles-in-patients-with-ankylosing-spondylitis-an-ultrasonographic-study
#14
Ahmet Üşen, Banu Kuran, Figen Yılmaz, Neşe Aksu, Cem Erçalık
The objectives of the study are to compare abdominal muscle thickness in ankylosing spondylitis (AS) patients with healthy subjects and determine the factors affecting these muscle thickness. Thirty-five male patients with a previous diagnosis of AS according to the Modified New York criteria and a control group consisting of 35 healthy male individuals were included in this cross-sectional and case-control study. Thicknesses of the internal oblique (IO), external oblique (EO), and transversus abdominalis (TrA) muscles were measured with ultrasound (US)...
September 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28889257/evaluation-of-auditory-and-cochlear-functions-in-ankylosing-spondylitis-patients-according-to-the-site-of-involvement
#15
Duran Karataş, İsmail Doğan, Adnan Ekinci, Abdurrahman Yetiş, Müge Özcan
Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease of unknown origin with a prevalence rate about 1% in the population. Audiovestibular dysfunction is encountered in AS and sensorineural hearing loss is the most common form. The present study aimed to evaluate auditory and cochlear function in AS patients according to the site of involvement. A total of 47 patients followed for AS in the rheumatology outpatient clinic and 30 healthy controls were enrolled in the study. Subgroups of AS were identified according to the site of involvement...
September 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28883908/increased-levels-of-oxidative-stress-markers-soluble-cd40-ligand-and-carotid-intima-media-thickness-reflect-acceleration-of-atherosclerosis-in-male-patients-with-ankylosing-spondylitis-in-active-phase-and-without-the-classical-cardiovascular-risk-factors
#16
Agata Stanek, Armand Cholewka, Tomasz Wielkoszyński, Ewa Romuk, Karolina Sieroń, Aleksander Sieroń
OBJECTIVE: The primary aim of the study was to assess levels of oxidative stress markers, soluble CD40 ligand (sCD40L), serum pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF) as well as carotid intima-media thickness (IMT) in patients with ankylosing spondylitis (AS) with active phase without concomitant classical cardiovascular risk factors. MATERIAL AND METHODS: The observational study involved 96 male subjects: 48 AS patients and 48 healthy ones, who did not differ significantly regarding age, BMI, comorbid disorders, and distribution of classical cardiovascular risk factors...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28883472/the-relationship-between-hematological-indices-and-autoimmune-rheumatic-diseases-ards-a-meta-analysis
#17
Xuanyu Hao, Dongyang Li, Dan Wu, Ning Zhang
This meta-analysis was undertaken to investigate the relationship between hematological indices and autoimmune rheumatic diseases (ARDs). PubMed, Embase, and Web of Science were searchedfor studies of ARDs and hematological indices. Standardized mean difference (SMD) was calculated with confidence interval (CI) of 95%. 18 studies were included in our meta-analysis. Compared to the healthy control group, neutrophil-lymphocyte ratio (NLR) was increased in patients with ankylosing spongdylitis(AS), Behçet's disease(BD), andrheumatoid arthritis(RA)(SMD = 0...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882159/estrogen-attenuates-the-spondyloarthritis-manifestations-of-the-skg-arthritis-model
#18
Hyemin Jeong, Eun-Kyung Bae, Hunnyun Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Chan Hong Jeon, Eun-Mi Koh, Hoon-Suk Cha
BACKGROUND: Ankylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytokine production. This study aimed to evaluate the effect of estrogen on the disease activity of spondyloarthritis (SpA). METHODS: The effects of estrogen on the development of arthritis were evaluated by performing ovariectomy and 17β-estradiol (E2) pellet implantation in zymosan-treated SKG mice...
September 7, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28880727/prevalence-of-ankylosing-spondylitis-disease-activity-score-asdas-inactive-disease-in-a-cohort-of-patients-treated-with-tnf-alpha-inhibitors
#19
Sara Monti, Monica Todoerti, Veronica Codullo, Ennio Giulio Favalli, Martina Biggioggero, Andrea Becciolini, Carlomaurizio Montecucco, Roberto Caporali
BACKGROUND: Treat to target (T2T), aiming at inactive disease (ID), has become the recommended strategy for axial-SpA (ax-SpA). Using the Ankylosing Spondylitis Disease Activity Score (ASDAS), we assessed the prevalence of ID in ax-SpA patients treated with TNFα inhibitors (TNFi). METHODS: A multicentric, cross-sectional study was performed assessing disease activity status (BASDAI and ASDAS) of consecutive patients with ax-SpA on stable treatment with TNFi for at least six months...
September 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28879599/secular-trends-in-sickness-absence-among-swedish-patients-with-ankylosing-spondylitis-and-psoriatic-arthritis
#20
Christel Nielsen, Ingemar F Petersson, Lennart T H Jacobsson, Anna Jöud
The aim was to investigate whether secular trends in sickness absence (SA) were present in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA) receiving their diagnosis between 2002 and 2011. A repeated cross-sectional study design was used. Patients were identified in the Skåne Healthcare Register (SHR). A washout period of 18 months was applied. The general population seeking health care was used as a reference cohort. SA data from 2003 to 2012 were obtained from the Swedish Social Insurance Agency and converted into net days of SA per year...
September 6, 2017: Rheumatology International
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