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https://www.readbyqxmd.com/read/29916259/polymorphisms-c677t-and-a1298c-of-mthfr-gene-homocysteine-levels-and-prothrombotic-biomarkers-in-coronary-and-pulmonary-thromboembolic-disease
#1
Eulo Lupi-Herrera, María Elena Soto-López, Antonio de Jesús Lugo-Dimas, Marcela Elizabeth Núñez-Martínez, Ricardo Gamboa, Claudia Huesca-Gómez, Lilia Mercedes Sierra-Galán, Verónica Guarner-Lans
The activity of the enzyme methylenetetrahydrofolate reductase (MTHFR) determines homocysteine (Hcy) levels, and polymorphisms in its gene affect the activity of the enzyme. Changes in the enzyme's activity may lead to a higher susceptibility to develop arterial and venous thromboembolic disease. The aim was to analyze the relationship between the C677T and A1298C polymorphisms of MTHFR, Hcy levels, and prothrombotic biomarkers in pulmonary embolism (PE) and acute myocardial ischemia (AMI). Clinical files of patients with thromboembolic diseases having complete data and whose doctor had requested an assay to determine the polymorphisms of the MTHFR gene, Hcy levels, and prothrombotic biomarkers were studied to search for the correlation between mutations of the MTHFR gene and Hcy levels in the different diseases...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29914908/prevalence-and-outcomes-of-incidental-imaging-findings-umbrella-review
#2
Jack W O'Sullivan, Tim Muntinga, Sam Grigg, John P A Ioannidis
OBJECTIVE: To provide an overview of the evidence on prevalence and outcomes of incidental imaging findings. DESIGN: Umbrella review of systematic reviews. DATA SOURCES: Searches of MEDLINE, EMBASE up to August 2017; screening of references in included papers. ELIGIBILITY CRITERIA: Criteria included systematic reviews and meta-analyses of observational studies that gave a prevalence of incidental abnormalities ("incidentalomas")...
June 18, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29909851/may-thurner-syndrome-and-the-risk-of-pulmonary-embolism-in-patients-with-acute-deep-venous-thrombosis
#3
Song Jin, Ziqiang Sun, Xiaoqin Li, Tao Jian, Xing Jin, Sheng Li, Guodong Wang, Chong Ma, Kai Cui, Peng Xu
OBJECTIVE: Pulmonary embolism (PE) is the most common complication of deep venous thrombosis (DVT). May-Thurner syndrome (MTS) is known to increase the risk of DVT, but an association between MTS and PE has not been established. This study investigated an association between MTS and the risk of PE in patients with acute lower extremity DVT. METHODS: Between June 2014 and September 2016, there were 112 patients with DVT at our hospital who underwent venous angiography and computed tomography pulmonary angiography...
July 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29907418/long-term-experience-with-a-mandatory-clinical-decision-rule-and-mandatory-d-dimer-in-the-evaluation-of-suspected-pulmonary-embolism
#4
Guy W Soo Hoo, Emily Tsai, Sondra Vazirani, Zhaoping Li, Bruce M Barack, Carol C Wu
PURPOSE: This study evaluated the long-term effectiveness of mandatory assignment of both a clinical decision rule (CDR) and highly sensitive d-dimer in the evaluation of patients with suspected pulmonary embolism (PE). MATERIALS AND METHODS: Institutional guidelines with a CDR and highly sensitive d-dimer were embedded in an order entry menu with mandatory assignment of key components before ordering a CT pulmonary angiogram (CTPA). Data were retrospectively extracted from the electronic health record...
June 12, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29904500/simultaneous-transarterial-and-transvenous-coil-embolization-for-a-large-aneurysmal-type-renal-arteriovenous-fistula
#5
Keita Nakayama, Masashi Shimohira, Kengo Ohta, Kazushi Suzuki, Taeko Goto, Yusuke Sawada, Yuta Shibamoto
A 74-year-old woman underwent abdominal computed tomography for screening, and a right large aneurysmal-type renal arteriovenous fistula (AVF) was found incidentally. The venous sac of the renal arteriovenous fistula was enlarged, and coil embolization was considered. To prevent severe complications such as coil migration, pulmonary embolism, and rupture during procedure, coil embolization was approached via both the feeding artery and the draining vein simultaneously, with balloon occlusion of the feeding artery...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904464/inferior-vena-cava-filter-placement-in-a-left-ivc-and-drainage-into-duplicated-svc-via-hemiazygous-continuation
#6
Jennifer Sweeney, Nainesh Parikh
Left-sided inferior vena cava (IVC) is the second most common anatomical anomaly of the IVC. We report a drainage pattern of the left IVC into a left duplicated superior vena cava (SVC) diagnosed during IVC filter placement consultation. The patient was a 66-year-old man with symptomatic hematuria caused by bladder cancer diagnosed with IVC thrombus and a left IVC found on a staging computed tomography urogram. The patient underwent computed tomography pulmonary angiogram, which ruled out pulmonary embolism, but demonstrated hemiazygous continuation of the left IVC above the diaphragm to meet a persistent left SVC (prevalence approximately 0...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29889260/pulmonary-infarction-right-upper-quadrant-pain-as-a-presenting-symptom-with-review-of-typical-computed-tomography-imaging-features
#7
Steven T Fosmire, Guy N Gibson, John C Copeland, Marcus S Maydew, Christian Eggers
The purpose of this case presentation is to discuss right upper quadrant pain as an atypical presenting symptom in pulmonary infarction and review the typical computed tomography (CT) imaging features of pulmonary infarction to improve diagnostic accuracy. Pulmonary infarction results from occlusion of distal arterial vasculature within the lung parenchyma leading to ischemia, hemorrhage, and ultimately necrosis. Patients with lung infarction typically present with pleuritic chest pain and may have associated signs or symptoms of pulmonary thromboembolism or deep vein thrombosis...
June 8, 2018: Military Medicine
https://www.readbyqxmd.com/read/29880626/-campylobacter-jejuni-and-pseudomonas-coinfection-in-the-setting-of-ulcerative-colitis
#8
John Paul Iguidbashian, Jai D Parekh, Shweta Kukrety, Venkata Giri Andukuri
A 66-year-old woman presented with 2 days of fever and severe diarrhoea. She has a history of ulcerative colitis (UC), well controlled with medication. She also has a history of Ehlers-Danlos syndrome, infective endocarditis following aortic valve replacement and pulmonary embolism. She had complained of passing stool with traces of blood about 30 times per day. Stool testing for Clostridium difficile, routine culture and microscopy was done. She was started on ceftriaxone. CT scan revealed thick-walled colon consistent with UC flare...
June 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29880624/unexpected-early-complication-of-implantable-cardioverter-defibrillator
#9
Ahmed Abdelhafez, Nancy Wassef, Kai Hogrefe, Mohsin Farooq
A 41-year-old woman was visiting Oxford, where she had a sudden cardiac arrest. Cardiopulmonary resuscitation was started by a bystander until the paramedics arrived, who found her in ventricular fibrillation, and delivered three shocks. After 28 min she had return of spontaneous circulation. Emergency coronary angiography revealed normal coronary arteries. Echocardiography followed by a cardiac MRI showed non-dilated left ventricles with no evidence of late gadolinium enhancement. She had a single-chamber implantable-cardioverter defibrillator (ICD)...
June 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29880507/abnormal-ventilation-perfusion-scan-is-associated-with-pulmonary-hypertension-in-sickle-cell-adults
#10
Alem Mehari, Norris Igbineweka, Darlene Allen, Jim Nichols, Swee Lay Thein, Nargues A Weir
Pulmonary hypertension (PH) in adults with sickle cell disease (SCD) is associated with early mortality. Chronic thromboembolic pulmonary hypertension (CTEPH) is an important complication and contributor to PH in SCD, but likely underappreciated. Guidelines recommend ventilation-perfusion scintigraphy (V/Q) as imaging modality of choice to exclude CTEPH. Data on V/Q are limited in SCD. Objective: To compare the performance of V/Q with computed tomography pulmonary angiography (CTPA) and to report clinical outcomes associated with abnormal V/Q...
June 7, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29876696/prophylaxis-of-postoperative-venous-thromboembolism-using-enoxaparin-after-esophagectomy-a-prospective-observational-study-of-effectiveness-and-safety
#11
Naoya Yoshida, Yoshifumi Baba, Yuji Miyamoto, Masaaki Iwatsuki, Yukiharu Hiyoshi, Takatsugu Ishimoto, Yu Imamura, Masayuki Watanabe, Hideo Baba
BACKGROUND: The incidence of venous thromboembolism (VTE) after esophagectomy is higher than in other gastroenterological cancer surgery. Although the effectiveness and safety of thromboprophylaxis using enoxaparin have been established in orthopedic, abdominal, and pelvic surgeries, no studies regarding esophagectomy are available. METHODS: A prospective observational study was conducted to elucidate the usefulness of enoxaparin for VTE prophylaxis after esophagectomy...
June 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29875063/life-threatening-pulmonary-embolism-that-occurred-immediately-after-acute-carbon-monoxide-poisoning-in-the-emergency-department
#12
Seok Jeong Lee, Yong Sung Cha, Yoonsuk Lee, Hyun Kim
The risk of thromboembolism is higher in those with carbon monoxide (CO) poisoning than in the general population. Pulmonary embolisms (PE) usually develop during admission for acute CO poisoning. We report the first case of a life-threatening PE that occurred immediately after acute CO poisoning and was treated with a thrombolytic agent. A 38-year-old woman presented at the emergency department with a stuporous mental status immediately after acute CO poisoning. She was started on hyperbaric oxygen therapy (HBOT), which maintained her hemodynamic stability...
May 30, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29874934/invasive-pulmonary-aspergillosis-secondary-to-microwave-ablation-a-multicenter-retrospective-study
#13
Guanghui Huang, Xin Ye, Xia Yang, Chuntang Wang, Licheng Zhang, Guangdong Ji, Kaixian Zhang, Huili Wang, Aimin Zheng, Wenhong Li, Jiao Wang, Xiaoying Han, Zhigang Wei, Min Meng, Yang Ni
PURPOSE: Invasive pulmonary aspergillosis (IPA) is a life-threatening complication of microwave ablation (MWA) during the treatment of primary or metastatic lung tumors. The purpose of this study was to investigate the clinical, radiological and demographic characteristics and treatment responses of patients with IPA after MWA. MATERIALS AND METHODS: From January 2011 to January 2016, all patients who were treated by MWA of their lung tumors from six health institutions were enrolled in this study...
June 6, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29873646/-percutaneous-treatment-of-coronary-artery-fistula-a-tailored-strategy-is-needed
#14
Filippo Russo, Anita Paggi, Giuseppe De Nittis, Mario Galli
Coronary artery fistula (CAF) is a rare, abnormal connection between one or more coronary arteries and a cardiac chamber, or great vessel.We describe the case of a male patient with worsening effort angina referred for coronary angiography. The examination revealed the presence of a CAF between the proximal left anterior descending (LAD) and pulmonary arteries, with mid LAD subocclusive stenosis. Ad hoc PCI with stenting was performed in the mid LAD, followed by CAF embolization with coils and plugs. Angiography and computed tomography scan at follow-up showed complete CAF occlusion, stent patency, and normal flow reserve of the LAD...
March 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29873308/assessment-of-the-current-d-dimer-cutoff-point-in-pulmonary-embolism-workup-at-a-single-institution-retrospective-study
#15
S Alhassan, E Bihler, K Patel, S Lavudi, M Young, M Balaan
Background: The currently used D-dimer (DD) cutoff point is associated with a large number of negative CT-pulmonary angiographies (CTPA). We hypothesized presence of deficiency in the current cutoff and a need to look for a better DD threshold. Materials and Methods: We conducted a retrospective medical records analysis of all patients who had a CTPA as part of pulmonary embolism (PE) workup over a 1-year period. All emergency room (ER) patients who had DD assay checked prior to CTPA were included in the analysis...
June 6, 2018: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29872303/incidence-of-venous-thromboembolism-in-psychiatric-inpatients-a-chart-review
#16
Masahiro Takeshima, Hiroyasu Ishikawa, Kazumi Shimizu, Takashi Kanbayashi, Tetsuo Shimizu
Purpose: Venous thromboembolism (VTE) is the combination of pulmonary embolism (PE) and deep vein thrombosis. In recent years, VTE has been gaining attention in the field of psychiatry as it can cause sudden deaths in patients hospitalized in psychiatric departments. The purpose of this study was to investigate the incidence of VTE in psychiatric inpatients using contrast-enhanced computed tomography (CT). Patients and methods: At the psychiatric department of the Akita University Hospital, NANOPIA® D-dimer was measured in patients with suspected symptomatic VTE or believed to be at risk for asymptomatic VTE...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29871009/-lung-scintigraphy
#17
Carl Schümichen, Matthias Schmidt, Thomas Krause
The S1 guideline for lung scintigraphy has been updated and extended in order to emphasize the advantages oft the method in detecting acute pulmonary embolism (PE) in the periphery oft the lung (subsegmental PE), in underlying subacute and chronic pulmonary disorders, as well as in detecting chronic LE (CTEPH). Method of choice is ventilation / perfusion (V/P) SPECT or V/P SPECT/CT with even higher specificity. Because of its high sensitivity, a threshold (V/P mismatch in at least one segment or two subsegments) is introduced to avoid overtreatment...
June 2018: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/29869406/age-adjusted-cut-off-using-the-il-d-dimer-hs-assay-to-exclude-pulmonary-embolism-in-patients-presenting-to-emergency
#18
Ming Sheng Lim, Ashwini Bennett, Sanjeev Chunilal
BACKGROUND: The ADJUST-PE study showed that an age adjusted D-dimer (AADD) (age years X 10ng/ml if >50 years) combined with an unlikely pre-test probability (PTP) can increase the proportion of older patients whom pulmonary embolism (PE) can be safely excluded but the IL D-dimer HS assay was not assessed. AIM: To assess the ability of the IL D-dimer HS assay to exclude PE using the AADD. METHODS: Retrospective analysis of consecutive patients presenting with symptoms of acute PE to one of three Monash Health Emergency Departments (January 2013-January 2014) who had Computer Tomography Pulmonary Angiography (CTPA)...
June 5, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29866211/age-adjusted-d-dimer-thresholds-in-the-investigation-of-suspected-pulmonary-embolism-a-retrospective-evaluation-in-patients-ages-50-and-older-using-administrative-data
#19
Kevin Senior, Kristin Burles, Dongmei Wang, Daniel Grigat, Grant D Innes, James E Andruchow, Eddy S Lang, Andrew D McRae
CLINICIAN'S CAPSULE What is known about the topic? Age-adjusted D-dimer thresholds have been proposed to improve specificity of diagnostic testing for thromboembolism in patients ages 50 and over. What did this study ask? What is the diagnostic accuracy of an age-adjusted D-dimer threshold in a population of patients undergoing investigations for suspected pulmonary embolism (PE)? What did this study find? Age-adjusted D-dimer cut-offs improved specificity but at the expense of a slightly higher risk of missed PE...
June 5, 2018: CJEM
https://www.readbyqxmd.com/read/29859696/venous-thromboembolic-complications-with-and-without-intermittent-intraoperative-and-postoperative-pneumatic-compression-in-patients-with-glioblastoma-multiforme-using-intraoperative-magnetic-resonance-imaging-a-retrospective-study
#20
M Ebeling, W Lüdemann, J Frisius, M Karst, I Schedel, V Gerganov, A Samii, R Fahlbusch
OBJECTIVE: To evaluate the effectiveness of intraoperative and postoperative intermittent pneumatic compression (IPC) as a method used to decrease the incidence of deep venous thrombosis (DVT), in comparison to the standard use of graduated compression stockings, low-molecular weight heparin (LMWH) and physiotherapy during the hospital stay. All patients in this study underwent intracranial surgery for glioblastoma multiforme (GBM) using intraoperative magnetic resonance imaging (MRI) guidance...
May 30, 2018: Neuro-Chirurgie
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