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https://www.readbyqxmd.com/read/29214637/identification-and-treatment-of-gestational-trophoblastic-neoplasia-located-in-the-cesarean-scar
#1
Xiaoyu Wang, Yuan Li, Junjun Yang, Yonglan He, Ming Wang, Xirun Wan, Yang Xiang
OBJECTIVE: To identify the clinical characteristics of, and the diagnostic and therapeutic strategies for, gestational trophoblastic neoplasia (GTN) located in the cesarean scar. METHODS: The present retrospective analysis was conducted among patients diagnosed with GTN located in the cesarean scar at Peking Union Medical College Hospital, Beijing, China, between June 1, 2006, and May 31, 2016. Clinical features, diagnostic and therapeutic procedures, and outcomes were reviewed...
December 6, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29072060/risk-factors-for-hydatidiform-mole-is-husband%C3%A2-s-job-a-major-risk-factor
#2
Hourieh Shamshiri Milani, Morteza Abdollahi, Sara Torbati, Taha Asbaghi, Eznollah Azargashb
Background: The hydatidiform mole (HM) is a precancerous placenta considered as a gestational trophoblastic disease (GTD). It may convert to more invasive forms of gestational trophoblastic neoplasia (GTN), endangering women’s health by more severe complications. Most GTN cases originate from HM, which is associated with uterine bleeding, preeclampsia and thyroid problems. Its etiology has not been adequately explored, but some risk factors have been reported. The aim of the present study was to assess any relationships between molar pregnancy and factors including mothers’ and husbands’ occupations...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29025533/negative-%C3%AE-hcg-and-molar-pregnancy-the-hook-effect
#3
Isabel Lobo Antunes, Joana Curado, Ana Quintas, Alcides Pereira
Molar pregnancy, included in gestational trophoblastic disease, is a benign pathology with ability to metastasize, usually occurring with excessively high βhCG levels. Clinical scenario is usually a woman in extremes of reproductive age presenting with amenorrhoea, pain and vaginal blood loss; signs derived from high βhCG levels may be present (hyperthyroidism, hyperemesis). Diagnosis is based on a positive pregnancy test - usually a qualitative urinary test. The limitation of this test results from its inability to become positive in presence of markedly high levels of βhCG, saturating the antigens used - known as the 'hook effect'...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29025247/molecular-and-histological-characteristics-of-early-triploid-and-partial-molar-pregnancies
#4
Katerina Kubelka-Sabit, Dzengis Jasar, Vanja Filipovski, Gorgi Bozinovski, Dijana Plaseska-Karanfilska
Molar pregnancy has the highest incidence of all gestational trophoblastic diseases. This is a heterogeneous group of diseases, composed of precancerous lesions and gestational trophoblastic tumours. The hydatidiform mole is characterised by varying degrees of proliferation of syncytiotrophoblastic and cytotrophoblastic cells and stromal oedema. Based on established morphological and cytogenetic criteria, molar pregnancy is divided into partial and complete. The risk of persistent trophoblastic disease is higher in complete moles compared with partial moles...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29020788/-complete-molar-pregancy-with-development-of-non-metastatic-persistent-trophoblastic-diseasea-case-report-reflection-of-rules-of-care-and-decision-making-processes-forensic-responsibility-and-the-position-of-doctor-in-the-general-gynecologic-and-obstetric-outpatient
#5
S Zeman, P Trávník, K Dvořáková, J Zemanová
OBJECTIVE: To define the forensic responsibility and the position of doctor in the general gynecologic and obstetric outpatient practice in care of the complete molar pregancy. DESIGN: Case report and review article. SETTING: General gynecologic and obstetric outpatient practice Velké Meziříčí; Sanatorium REPROMEDA, Centre of reproductive medicine and preimplantation genetics, Brno; Histopatology department of Hospital Jihlava. CASE REPORT: The changing clinical presentation of complete molar pregnancy with development of non-metastatic gestational trophoblastic disease: management...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28974845/challenges-in-the-routine-praxis-diagnosis-of-hydatidiform-mole-a-tertiary-health-center-experience
#6
Melisa Lelic, Zlatan Fatusic, Ermina Iljazovic, Suada Ramic, Sergije Markovic, Selma Alicelebic
INTRODUCTION: Hydatidiform moles (HM), presenting as complete (CHM) and partial (PHM) form, are rare pregnancy disorder. Diagnosis is based on clinical presentation, ultrasound imaging findings and pathological examination of products of conception. Protein p57, encoded by CKDN1C gene, is paternally imprinted and maternally expressed gene and provides quick insight in genetic basis of HM and allows distinction of CHM from all other conceptions. compare the preevacuational and pathohistological diagnosis with outcome of p57 immunostaining...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28934718/urinary-bpa-and-phthalate-metabolite-concentrations-and-plasma-vitamin-d-levels-in-pregnant-women-a-repeated-measures-analysis
#7
Lauren E Johns, Kelly K Ferguson, David E Cantonwine, Thomas F McElrath, Bhramar Mukherjee, John D Meeker
BACKGROUND: In addition to its well-established role in maintaining skeletal health, vitamin D has essential regulatory functions in female reproductive and pregnancy outcomes. Phthalates and bisphenol A (BPA) are endocrine disruptors, and previous research has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults. OBJECTIVES: We investigated the relationships between repeated measures of urinary phthalate metabolites and BPA and circulating total 25(OH)D in a prospective cohort of pregnant women...
August 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28927899/does-hormonal-contraception-during-molar-pregnancy-follow-up-influence-the-risk-and-clinical-aggressiveness-of-gestational-trophoblastic-neoplasia-after-controlling-for-risk-factors
#8
Patrícia Rangel Sobral Dantas, Izildinha Maestá, Jorge Rezende Filho, Joffre Amin Junior, Kevin M Elias, Neil Howoritz, Antonio Braga, Ross S Berkowitz
OBJECTIVE: To evaluate the influence of hormonal contraception (HC) on the development and clinical aggressiveness of gestational trophoblastic neoplasia (GTN) and the time for normalization of human chorionic gonadotropin (hCG) levels. METHODS: A retrospective cohort study was conducted with women diagnosed with molar pregnancy, followed at the Rio de Janeiro Trophoblastic Disease Center, between January 2005 and January 2015. The occurrence of postmolar GTN and the time for hCG normalization between users of HC or barrier methods (BM) during the postmolar follow-up or GTN treatment were evaluated...
November 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28924538/molecular-and-immunohistochemical-characteristics-of-complete-hydatidiform-moles
#9
K B Kubelka-Sabit, I Prodanova, D Jasar, G Bozinovski, V Filipovski, S Drakulevski, D Plaseska-Karanfilska
Molar pregnancy is a gestational trophoblastic disease that belongs to the category of precancerous lesions. On the other end of the spectrum are gestational trophoblastic neoplasms such as invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor, which are considered malignant tumors. Based on defined histopathological criteria, molar pregnancy is divided into partial and complete hydatidiform mole. Especially in the case of early complete mole, the diagnosis can be quite challenging and often necessitates additional molecular or immunohistochemical methods...
June 30, 2017: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/28892983/transient-thyrotoxicosis-in-molar-pregnancy
#10
Samarth Virmani, Sujatha B Srinivas, Rama Bhat, Raghavendra Rao, Ranjini Kudva
Molar pregnancy is one of the components of a broader spectrum of diseases known as Gestational Trophoblastic Disease (GTD), presenting with amenorrhoea and irregular bleeding which may be rarely associated with passage of vesicles per vagina. However, it can rarely be associated with hyperthyroidism, which may be associated with clinical features of hyperthyroidism. The following is a report of a 20-year-old woman who presented with amenorrhea followed by irregular bleeding per vagina, thyromegaly and abnormal levels of thyroid hormones...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892119/prophylactic-chemotherapy-for-hydatidiform-mole-to-prevent-gestational-trophoblastic-neoplasia
#11
REVIEW
Qiuyi Wang, Jing Fu, Lina Hu, Fang Fang, Lingxia Xie, Hengxi Chen, Fan He, Taixiang Wu, Theresa A Lawrie
BACKGROUND: This is an update of the original Cochrane Review published in Cochrane Library, Issue 10, 2012.Hydatidiform mole (HM), also called a molar pregnancy, is characterised by an overgrowth of foetal chorionic tissue within the uterus. HMs may be partial (PM) or complete (CM) depending on their gross appearance, histopathology and karyotype. PMs usually have a triploid karyotype, derived from maternal and paternal origins, whereas CMs are diploid and have paternal origins only...
September 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28877059/choriocarcinoma-in-women-analysis-of-a-case-series-with-genotyping
#12
COMPARATIVE STUDY
Johanna Savage, Emily Adams, Emanuela Veras, Kathleen M Murphy, Brigitte M Ronnett
Choriocarcinoma is an uncommon malignant neoplasm, which can be either gestational or nongestational in origin. Distinction of these subtypes has prognostic and therapeutic implications. Twenty-two tumors were genotyped using polymerase chain reaction amplification of 15 short tandem repeat loci and the amelogenin locus (XY determination). DNA patterns from tumor and maternal tissue, as well as villous tissue from any available prior or concurrent gestation, were compared, to determine gestational versus nongestational nature (containing vs...
December 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28867693/mild-thyroid-peroxidase-deficiency-caused-by-tpo-mutations-with-residual-activity-correlation-between-clinical-phenotypes-and-enzymatic-activity
#13
Satoshi Narumi, Larry A Fox, Keisuke Fukudome, Zenichi Sakaguchi, Chiho Sugisawa, Kiyomi Abe, Kaori Kameyama, Tomonobu Hasegawa
Thyroid peroxidase (TPO) deficiency, caused by biallelic TPO mutations, is a well-established genetic form of congenital hypothyroidism (CH). More than 100 patients have been published, and the patients have been diagnosed mostly in the frame of newborn screening (NBS) programs. Correlation between clinical phenotypes and TPO activity remains unclear. Here, we report clinical and molecular findings of two unrelated TPO mutation-carrying mildly hypothyroid patients. The two patients were born at term after an uneventful pregnancy and delivery, and were NBS negative...
September 1, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28858831/urinary-concentrations-of-organophosphate-flame-retardant-metabolites-and-pregnancy-outcomes-among-women-undergoing-in-vitro-fertilization
#14
Courtney C Carignan, Lidia Mínguez-Alarcón, Craig M Butt, Paige L Williams, John D Meeker, Heather M Stapleton, Thomas L Toth, Jennifer B Ford, Russ Hauser
BACKGROUND: Evidence from animal studies suggests that exposure to organophosphate flame retardants (PFRs) can disrupt endocrine function and impair embryo development. However, no epidemiologic studies have been conducted to evaluate effects on fertility and pregnancy outcomes. OBJECTIVES: We evaluated associations between urinary concentrations of PFR metabolites and outcomes of in vitro fertilization (IVF) treatment among couples recruited from an academic fertility clinic...
August 25, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28856829/efficacy-and-safety-of-very-early-medical-termination-of-pregnancy-a-cohort-study
#15
I Bizjak, C Fiala, L Berggren, H Hognert, I Sääv, J Bring, K Gemzell-Danielsson
OBJECTIVE: To assess the efficacy and safety of medical termination of pregnancy (MTOP) when no intrauterine pregnancy (IUP) is confirmed on ultrasound. DESIGN: Retrospective case-note review. SETTING: Two gynaecological clinics in Vienna, Austria, and Gothenburg, Sweden. POPULATION: All women with gestations of ≤49 days undergoing an MTOP during 2004-14 (Vienna) and 2012-15 (Gothenburg). METHODS: Two study cohorts were created: women with and women without a confirmed IUP...
August 30, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28833715/exploring-the-association-between-genetic-and-environmental-factors-and-molar-incisor-hypomineralization-evidence-from-a-twin-study
#16
Rafael José Pio Barbosa Teixeira, Natália Silva Andrade, Lisanca Carvalho Cavalcante Queiroz, Fausto Medeiros Mendes, Marcoeli Silva Moura, Lúcia de Fátima Almeida de Deus Moura, Marina Deus Moura Lima
BACKGROUND: The etiology of molar-incisor hypomineralization (MIH) remains unknown. Studies indicate that it is multifactorial, and that genetic and environmental factors are involved. Research with twins provides important subsidy to investigate the Influence of genetics and environmental factors that act during pregnancy on the etiology of alterations. AIM: This cross-sectional study evaluated the agreement of molar incisor hypomineralization (MIH) between monozygotic and dizygotic twin pairs and the association with environmental factors...
August 22, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28800576/heterotopic-pregnancy-including-intrauterine-normal-gestation-and-tubal-complete-hydatidiform-mole-a-case-report-and-review-of-the-literature
#17
Dan Lu, Jian Jenny Tang, Konstantin Zakashansky, Ross S Berkowitz, Tamara Kalir, Yuxin Liu
We report a rare case of heterotopic pregnancy with intrauterine normal gestation alongside tubal complete hydatidiform mole (CHM) that resulted in a viable pregnancy after removal of molar tissue. Because of their rarity and inherent complexity, such cases represent a significant challenge in diagnosis and management. A 34-year-old female in her 10th week of gestation presented with nausea, vomiting, and intermittent abdominal pain that progressively worsened. Imaging studies revealed a normal intrauterine fetus and an 11-cm heterogenous mass in the left adnexal region...
September 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28717722/gestational-trophoblastic-neoplasia-treatment-at-the-butaro-cancer-center-of-excellence-in-rwanda
#18
Ignace Nzayisenga, Roanne Segal, Natalie Pritchett, Mary J Xu, Paul H Park, Edgie V Mpanumusingo, Denis G Umuhizi, Donald P Goldstein, Ross S Berkowitz, Vedaste Hategekimana, Clemence Muhayimana, Fidel Rubagumya, Temidayo Fadelu, Neo Tapela, Tharcisse Mpunga, Rahel G Ghebre
PURPOSE: Gestational trophoblastic neoplasia (GTN) is a highly treatable disease, most often affecting young women of childbearing age. This study reviewed patients managed for GTN at the Butaro Cancer Center of Excellence (BCCOE) in Rwanda to determine initial program outcomes. PATIENTS AND METHODS: A retrospective medical record review was performed for 35 patients with GTN assessed or treated between May 1, 2012, and November 30, 2014. Stage, risk score, and low or high GTN risk category were based on International Federation of Gynecology and Obstetrics staging and the WHO scoring system and determined by beta human chorionic gonadotropin level, chest x-ray, and ultrasound per protocol guidelines for resource-limited settings...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28713902/establishment-and-characterization-of-cell-lines-derived-from-complete-hydatidiform-mole
#19
Eiko Yamamoto, Kaoru Niimi, Tohru Kiyono, Toshimichi Yamamoto, Kimihiro Nishino, Kenichi Nakamura, Tomomi Kotani, Hiroaki Kajiyama, Kiyosumi Shibata, Fumitaka Kikkawa
Gestational trophoblastic diseases (GTDs) are a group of diseases characterized by abnormal cellular proliferation of atypical trophoblasts. A hydatidiform mole is an abnormal pregnancy caused by genetic fertilization disorders, and it can be classified as a complete hydatidiform mole (CHM) or a partial hydatidiform mole. The aim of this study was to establish cell lines from CHMs and to characterize the cells for future studies concerning GTD. HMol1-2C, HMol1-3B, HMol1-8 and HMol3-1B were established from primary cultures of CHM explants following the introduction of different combinations of genes including human telomerase reverse transcriptase (hTERT), a mutant form of CDK (CDK4R24C), cyclin D1, p53C234, MYC and HRAS...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28691418/associations-between-the-number-of-natural-teeth-and-the-maternal-age-at-childbirth-or-history-of-parity-in-postmenopausal-women-the-2010-2012-korea-national-health-and-nutrition-examination-survey
#20
Kyungdo Han, Insoo Kim, Yong-Gyu Park, Jun-Beom Park
BACKGROUND: The relationship between reproductive factors, including pregnancy and delivery in postmenopausal women, and the number of teeth remains to be revealed. OBJECTIVES: This study evaluated the relationship between childbearing age (age at first and last delivery), parity and the number of natural teeth in postmenopausal women using nationally representative data. MATERIAL AND METHODS: The data from the Korea National Health and Nutrition Examination Survey between 2010 and 2012 were used, and the analysis in this study was confined to a total of 4,060 respondents over 19 years old who had gone through menopause and had no missing values for the reproductive factors and outcome variables...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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