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https://www.readbyqxmd.com/read/28800576/heterotopic-pregnancy-including-intrauterine-normal-gestation-and-tubal-complete-hydatidiform-mole-a-case-report-and-review-of-the-literature
#1
Dan Lu, Jian Jenny Tang, Konstantin Zakashansky, Ross S Berkowitz, Tamara Kalir, Yuxin Liu
We report a rare case of heterotopic pregnancy with intrauterine normal gestation alongside tubal complete hydatidiform mole (CHM) that resulted in a viable pregnancy after removal of molar tissue. Because of their rarity and inherent complexity, such cases represent a significant challenge in diagnosis and management. A 34-year-old female in her 10th week of gestation presented with nausea, vomiting, and intermittent abdominal pain that progressively worsened. Imaging studies revealed a normal intrauterine fetus and an 11-cm heterogenous mass in the left adnexal region...
September 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28717722/gestational-trophoblastic-neoplasia-treatment-at-the-butaro-cancer-center-of-excellence-in-rwanda
#2
Ignace Nzayisenga, Roanne Segal, Natalie Pritchett, Mary J Xu, Paul H Park, Edgie V Mpanumusingo, Denis G Umuhizi, Donald P Goldstein, Ross S Berkowitz, Vedaste Hategekimana, Clemence Muhayimana, Fidel Rubagumya, Temidayo Fadelu, Neo Tapela, Tharcisse Mpunga, Rahel G Ghebre
PURPOSE: Gestational trophoblastic neoplasia (GTN) is a highly treatable disease, most often affecting young women of childbearing age. This study reviewed patients managed for GTN at the Butaro Cancer Center of Excellence (BCCOE) in Rwanda to determine initial program outcomes. PATIENTS AND METHODS: A retrospective medical record review was performed for 35 patients with GTN assessed or treated between May 1, 2012, and November 30, 2014. Stage, risk score, and low or high GTN risk category were based on International Federation of Gynecology and Obstetrics staging and the WHO scoring system and determined by beta human chorionic gonadotropin level, chest x-ray, and ultrasound per protocol guidelines for resource-limited settings...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28713902/establishment-and-characterization-of-cell-lines-derived-from-complete-hydatidiform-mole
#3
Eiko Yamamoto, Kaoru Niimi, Tohru Kiyono, Toshimichi Yamamoto, Kimihiro Nishino, Kenichi Nakamura, Tomomi Kotani, Hiroaki Kajiyama, Kiyosumi Shibata, Fumitaka Kikkawa
Gestational trophoblastic diseases (GTDs) are a group of diseases characterized by abnormal cellular proliferation of atypical trophoblasts. A hydatidiform mole is an abnormal pregnancy caused by genetic fertilization disorders, and it can be classified as a complete hydatidiform mole (CHM) or a partial hydatidiform mole. The aim of this study was to establish cell lines from CHMs and to characterize the cells for future studies concerning GTD. HMol1-2C, HMol1-3B, HMol1-8 and HMol3-1B were established from primary cultures of CHM explants following the introduction of different combinations of genes including human telomerase reverse transcriptase (hTERT), a mutant form of CDK (CDK4R24C), cyclin D1, p53C234, MYC and HRAS...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28691418/associations-between-the-number-of-natural-teeth-and-the-maternal-age-at-childbirth-or-history-of-parity-in-postmenopausal-women-the-2010-2012-korea-national-health-and-nutrition-examination-survey
#4
Kyungdo Han, Insoo Kim, Yong-Gyu Park, Jun-Beom Park
BACKGROUND: The relationship between reproductive factors, including pregnancy and delivery in postmenopausal women, and the number of teeth remains to be revealed. OBJECTIVES: This study evaluated the relationship between childbearing age (age at first and last delivery), parity and the number of natural teeth in postmenopausal women using nationally representative data. MATERIAL AND METHODS: The data from the Korea National Health and Nutrition Examination Survey between 2010 and 2012 were used, and the analysis in this study was confined to a total of 4,060 respondents over 19 years old who had gone through menopause and had no missing values for the reproductive factors and outcome variables...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28653031/the-hook-effect-causing-a-negative-pregnancy-test-in-a-patient-with-an-advanced-molar-pregnancy
#5
Abigail D Winder, Adria Suarez Mora, Emily Berry, John R Lurain
•At high hCG levels in molar pregnancies, a "hook effect" can cause an artificially negative value.•Delay in diagnosis of a molar pregnancy due to the "hook effect" can lead to severe complications.•Suspicion of a molar pregnancy should be communicated so a diluted sample is used to quantify hCG.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28607326/morphological-features-and-immunohistochemical-expression-of-p57kip2-in-early-molar-pregnancies-and-their-relations-to-the-progression-to-persistent-trophoblastic-disease
#6
Marwa Khashaba, Mohammad Arafa, Eman Elsalkh, Reda Hemida, Wagiha Kandil
BACKGROUND: Although the morphological features characteristic of products of conception specimens including molar pregnancies are well described, substantial histopathological similarities are observed between the different entities, especially in cases of early pregnancies. Furthermore, there are no current solid criteria that could predict cases with progression to persistent gestational trophoblastic disease. In this study, we aimed to determine the most specific histopathological and immunohistochemical features required for accurate diagnosis that can reliably predict the clinical behavior...
July 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28585844/-abdominal-pregnancy-at-a-patient-after-cesarean-section-bilateral-salpingectomy-and-embryotransfer
#7
E Suchánková, J Pavlásek, I Bydžovská, M Lubušký
OBJECTIVE: Presentation of rare complication following the assisted reproduction at a patient after cesarean section and bilateral salpingectomy. DESIGN: Case report. SETTINGS: Department of Obstetrics and Gynaecology, Regional Hospital Liberec, a. s.; Department of Obstetrics and Gynaecology, Palacky University Hospital, Olomouc. OBSERVATION: Pregnant woman, 26-years old, primiparous, with history of cesarean section and bilateral salpingectomy, was referred from the assisted reproduction centre to solve suspicion of molar intrauterine pregnancy...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28574027/utility-of-p57-immunohistochemistry-in-differentiating-between-complete-mole-partial-mole-non-molar-or-hydropic-abortus
#8
Abhimanyu Samadder, Rakhee Kar
BACKGROUND & OBJECTIVES: There is considerable inter-observer variability in the diagnosis of molar pregnancies by histomorphological examination of products of conception (POC). The p57KIP2 gene is paternally imprinted and expressed from the maternal allele. On immunohistochemistry (IHC) with p57, complete mole (CM) shows absent staining whereas hydropic abortus (HA) and partial mole (PM) show positive staining. This study was undertaken to evaluate the role of p57 IHC along with histomorphology in differentiating between CM, PM and non-molar or HA...
January 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28546716/complete-molar-pregnancy-in-postmenopausal-woman
#9
Ahmed Samy El-Agwany, Helmy Abdelsattar Rady, Hassan Mansour Hegab
Gestational trophoblastic disease spectrum ranges from benign hydatidiform mole to trophoblastic malignancy (placental site trophoblastic tumor and choriocarcinoma). Benign gestational trophoblastic disease occurs in women of reproductive age and is extremely rare in postmenopausal women. We describe a case of complete vesicular mole in a 55-year-old postmenopausal woman complaining of postmenopausal bleeding. To our knowledge, our case represents one of the rare descriptions in the world literature of a benign complete hydatidiform mole in a postmenopausal woman...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28515588/placental-mesenchymal-dysplasia-what-every-radiologist-needs-to-know
#10
Disha Mittal, Rama Anand, Neha Sisodia, Smita Singh, Ratna Biswas
Placental mesenchymal dysplasia (PMD) is an uncommon vascular anomaly of the placenta characterized by placentomegaly with multicystic placental lesion on ultrasonography and mesenchymal stem villous hyperplasia on histopathology. Placental mesenchymal dysplasia should be considered in the differential diagnosis of cases of multicystic placental lesion such as molar pregnancy, chorioangioma, subchorionic hematoma, and spontaneous abortion with hydropic placental changes. However, lack of high-velocity signals inside the lesion and a normal karyotype favor a diagnosis of PMD...
January 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28498254/a-novel-prediction-model-for-postmolar-gestational-trophoblastic-neoplasia-and-comparison-with-existing-models
#11
Peng Zhao, Shuangyan Wang, Xiuli Zhang, Weiguo Lu
OBJECTIVE: The aim of this study was to comparatively study a novel model and existing models of predicting postmolar gestational trophoblastic neoplasia (GTN). METHODS: Two hundred twenty-two patients with complete hydatidiform moles were enrolled retrospectively. A natural regression was noted in 195 patients (spontaneous regression group), whereas the remaining 27 patients entered postmolar GTN (postmolar GTN group). The upper limits of the 95% confidence interval of human chorionic gonadotropin (hCG) values and hCG regression rates were calculated aggregately from the spontaneous regression group...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28491173/radiographically-occult-pulmonary-metastases-from-gestational-trophoblastic-neoplasia
#12
Tina Hong, Edward Hills, Maria Del Pilar Aguinaga
Gestational trophoblastic neoplasia (GTN) is a spectrum of diseases including partial and complete hydatidiform moles, placental site trophoblastic tumor, and choriocarcinoma. One of the most important considerations is recognition of the possibility of GTN after molar pregnancy or even normal pregnancy. It is common practice to use chest x-ray for the detection of pulmonary metastasis. Computed tomography imaging of the lungs is ordered if lung lesions are noted on chest x-rays. However, understanding the limitations of chest x-rays is important for detecting smaller pulmonary lesions...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28489216/the-role-of-surgery-in-the-management-of-women-with-gestational-trophoblastic-disease
#13
Lana DE Lourdes Aguiar Lima, Lílian Padron, Raphael Câmara, Sue Yazaki Sun, Jorge Rezende, Antônio Braga
The Gestational Trophoblastic Disease includes an interrelated group of diseases originating from placental tissue, with distinct behaviors concerning local invasion and metastasis. The high sensitivity of the serial dosages of human chorionic gonadotrophin, combined with advances in chemotherapy treatment, have made gestational trophoblastic neoplasia curable, most often through chemotherapy. However, surgery remains of major importance in the management of patients with gestational trophoblastic disease, improving their prognosis...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28461032/clinical-characteristics-and-prognosis-of-ultra-high-risk-gestational-trophoblastic-neoplasia-patients-a-retrospective-cohort-study
#14
Yujia Kong, Junjun Yang, Fang Jiang, Jun Zhao, Tong Ren, Jie Li, Xiaoyu Wang, Fengzhi Feng, Xirun Wan, Yang Xiang
OBJECTIVE: The gestational trophoblastic neoplasia (GTN) patients with the International Federation of Gynecology and Obstetrics (FIGO) score≥12 are defined as ultra high-risk GTN. This study aims to investigate the clinical characteristics, the treatment efficiency, and the prognosis of ultra high-risk GTN patients. METHODS: Between January 2002 and December 2015, medical record data of 143 GTN patients with FIGO score≥12 at Peking Union Medical College Hospital (PUMCH) were reviewed...
July 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28431828/clinical-use-of-monopronucleated-zygotes-following-blastocyst-culture-and-preimplantation-genetic-screening-including-verification-of-biparental-chromosome-inheritance
#15
Cara K Bradley, Maria Traversa, Natalie Hobson, Alison J Gee, Steven J McArthur
In assisted reproduction, embryos derived from monopronucleated (1PN) zygotes are considered abnormal and unsuitable for clinical use. Outcomes of 1PN-derived embryos designated for preimplantation genetic screening (PGS) were analysed. These embryos, especially from intracytoplasmic sperm injection (ICSI), were found to have a low developmental potential; 1PN and 2PN day 5 blastocyst development for IVF was 14.8% versus 36.4% (P < 0.0001), and for ICSI, 6.6% versus 34.0% (P < 0.0001), respectively. With the use of comparative genomic hybridization or next-generation sequencing, PGS was successfully carried out for 74 IVF and 32 ICSI 1PN-derived blastocysts, revealing adjusted abnormality rates of 39...
March 27, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28403356/fluoxetine-effects-on-periodontogenesis-histomorphometrical-and-immunohistochemical-analyses-in-rats
#16
Luciana Silva Regueira, Priscylla Gonçalves Correia Leite de Marcelos, Isabela Maria Santiago-Jaegger, Danyel Elias da Cruz Perez, Joaquim Evêncio, Liriane Baratella-Evêncio
Objective: This study aimed to assess the effects of fluoxetine, a selective serotonin reuptake inhibitor, on the formation of the periodontal ligament during pregnancy and lactation in rat pups. Material and Methods: Twelve pregnant rats of Wistar lineage were divided into four study groups. In the control group, 0.9% sodium chloride solution was administered orally, throughout the entire period of the 21 days of pregnancy (CG group) and in the CGL group, it was administrated during pregnancy and lactation (from day 1 of pregnancy to the 21st day after birth)...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28377901/unusual-presentation-of-invasive-mole-a-case-report
#17
Soheila Aminimoghaddam, Andisheh Maghsoudnia
BACKGROUND: Invasive mole is responsible for most cases of localized gestational trophoblastic neoplasia. Gestational trophoblastic disease describes a number of gynecologic tumors that originate in trophoblastic layer including hydatidiform mole (complete or partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor and epitheloid trophoblastic tumor. Invasive mole may arise from any pregnancy event although in most cases is diagnosed after molar pregnancy. Overall cure rate in low risk patients is nearly 100% and in high-risk patient 90%...
January 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28338027/molar-incisor-hypomineralisation
#18
Greig D Taylor
Data sourcesThe Medline and Embase databases and hand searches in the journals International Journal of Paediatric Dentistry and European Archives of Paediatric Dentistry.Study selectionEnglish language cohort and case-control studies.Data extraction and synthesisStudy selection was carried out independently by two reviewers with data abstraction being conducted by a single reviewer and checked by a second reviewer. Risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale (NOS). Adjusted (aOR) and unadjusted odds ratios (uOR), P-values and 95% confidence intervals (CI) were obtained from the studies...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28329740/human-chorionic-gonadotropin-regression-curves-after-partial-or-complete-molar-pregnancy-in-flanders-are-they-different-from-regression-curves-from-the-eighties
#19
Sien Delattre, Sileny Han, Philippe Moerman, Jaak Billen, Frédéric Goffin, Kathleen Scharpé, Ignace Vergote
BACKGROUND/AIMS: We updated human chorionic gonadotropin (hCG) regression curves created in the eighties after evacuation of complete and partial molar (CM and PM, respectively) pregnancies using modern hCG assays. We created similar curves for patients in need of chemotherapy (gestational trophoblastic neoplasia [GTN]). METHODS: A total of 126 patients who were diagnosed with gestational trophoblastic disease from 1990 to 2014 were included. We compared curves from 2 groups, CM and PM, with historical ones...
March 23, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28287945/gestational-trophoblastic-disease-clinical-and-imaging-features
#20
Akram M Shaaban, Maryam Rezvani, Reham R Haroun, Anne M Kennedy, Khaled M Elsayes, Jeffrey D Olpin, Mohamed E Salama, Bryan R Foster, Christine O Menias
Gestational trophoblastic disease (GTD) is a spectrum of both benign and malignant gestational tumors, including hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The latter four entities are referred to as gestational trophoblastic neoplasia (GTN). These conditions are aggressive with a propensity to widely metastasize. GTN can result in significant morbidity and mortality if left untreated. Early diagnosis of GTD is essential for prompt and successful management while preserving fertility...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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