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Molar pregnancy

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https://www.readbyqxmd.com/read/29562309/diagnostic-utility-of-twist1-ki-67-and-e-cadherin-in-diagnosing-molar-gestations-and-hydropic-abortions
#1
Rabab A Moussa, Ahmed N Eesa, Zeinab F Abdallah, Ayman Abdelmeged, Ahmed Mahran, Haitham Bahaa
Objectives: This study aims to assess whether the expression of Twist1, Ki-67, and E-cadherin can guide the differential diagnosis of complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and hydropic abortion (HA). Methods: Differential expression of Twist1, Ki-67, and E-cadherin was analyzed in gestational products from 55 cases of CHM, PHM, and HA using immunohistochemistry. Prior to analysis, the studied cases were confirmed for their diagnosis by flow cytometric assessment of DNA ploidy and p57 immunostaining...
March 19, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29530747/use-of-intravenous-acetaminophen-in-postoperative-pain-management-after-partial-and-full-bony-impacted-third-molar-extractions-a-randomized-double-blind-controlled-trial
#2
Isabel Atencio, Max Beushausen, John J Kowalczyk, Andres Flores-Hidalgo, Nora F Fino, Dale A Baur
PURPOSE: Currently, there is a concern at the national level of the overuse of both prescription and nonprescription opioid use. The purpose of this study was to identify whether the use of the intravenous (IV) formulation of acetaminophen (Ofirmev; Mallinckrodt Pharmaceuticals, Staines-upon-Thames, United Kingdom) is an effective tool in the reduction of postoperative pain, with a secondary goal of reduction of postoperative narcotic use. MATERIALS AND METHODS: A total of 72 patients with previously diagnosed either partial bony or complete bony impacted third molars were selected with care to avoid long-acting local anesthetics or dissociative anesthetic agents...
February 20, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29528932/manual-compared-with-electric-vacuum-aspiration-for-treatment-of-molar-pregnancy
#3
Lilian Padrón, Jorge Rezende Filho, Joffre Amim Junior, Sue Yazaki Sun, Rafael Cortés Charry, Izildinha Maestá, Kevin M Elias, Neil Horowitz, Antonio Braga, Ross S Berkowitz
OBJECTIVE: To evaluate uterine evacuation of patients with molar pregnancy, comparing manual with electric vacuum aspiration. METHODS: This is a retrospective cohort study of patients with molar pregnancy followed at the Rio de Janeiro Trophoblastic Disease Center from January 2007 to December 2016. The individual primary study outcomes were incomplete uterine evacuation, uterine perforation, development of uterine synechia, and development of postmolar gestational trophoblastic neoplasia...
April 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29499913/determinants-of-organophosphate-pesticide-exposure-in-pregnant-women-a-population-based-cohort-study-in-the-netherlands
#4
Michiel A van den Dries, Anjoeka Pronk, Mònica Guxens, Suzanne Spaan, Trudy Voortman, Vincent W Jaddoe, Todd A Jusko, Matthew P Longnecker, Henning Tiemeier
BACKGROUND: In the Netherlands organophosphate (OP) pesticides are frequently used for pest control in agricultural settings. Despite concerns about the potential health impacts of low-level OP pesticides exposure, particularly in vulnerable populations, the primary sources of exposure remain unclear. The present study was designed to investigate the levels of DAP metabolites concentrations across pregnancy and to examine various determinants of DAP metabolite concentrations among an urban population of women in the Netherlands...
February 3, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29479882/cadmium-and-lead-in-women-who-miscarried
#5
Wioleta J Omeljaniuk, Katarzyna Socha, Jolanta Soroczynska, Angelika E Charkiewicz, Tadeusz Laudanski, Marek Kulikowski, Edward Kobylec, Maria H Borawska
BACKGROUND: Cadmium (Cd) and lead (Pb) are toxic elements which, when ingested excessively in food and drinking water, accumulate in selected organs and pass through the placenta barrier to the foetus, showing teratogenic effects. The aim of the study was to determine the concentration of Cd and Pb in blood and placental tissue in women who miscarried. METHODS: The study group consisted of 83 women who miscarried. The control group included 35 women in the first trimester of pregnancy and after childbirth...
January 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29463882/the-genetics-of-recurrent-hydatidiform-moles-new-insights-and-lessons-from-a-comprehensive-analysis-of-113-patients
#6
Ngoc Minh Phuong Nguyen, Yassemine Khawajkie, Nawel Mechtouf, Maryam Rezaei, Magali Breguet, Elvira Kurvinen, Sujatha Jagadeesh, Asli Ece Solmaz, Monica Aguinaga, Reda Hemida, Mehmet Ibrahim Harma, Cécile Rittore, Kurosh Rahimi, Jocelyne Arseneau, Karine Hovanes, Ronald Clisham, Tiffanee Lenzi, Bonnie Scurry, Marie-Claude Addor, Rashmi Bagga, Genevieve Girardet Nendaz, Vildana Finci, Gemma Poke, Leslie Grimes, Nerine Gregersen, Kayla York, Pierre-Adrien Bolze, Chirag Patel, Hossein Mozdarani, Jacques Puechberty, Jessica Scotchie, Majid Fardaei, Muge Harma, R J McKinlay Gardner, Trilochan Sahoo, Tracy Dudding-Byth, Radhika Srinivasan, Philippe Sauthier, Rima Slim
Hydatidiform mole is an aberrant human pregnancy characterized by early embryonic arrest and excessive trophoblastic proliferation. Recurrent hydatidiform moles are defined by the occurrence of at least two hydatidiform moles in the same patient. Fifty to eighty percent of patients with recurrent hydatidiform moles have biallelic pathogenic variants in NLRP7 or KHDC3L. However, in the remaining patients, the genotypic types of the moles are unknown. We characterized 80 new hydatidiform mole tissues, 57 of which were from patients with no mutations in the known genes, and we reviewed the genotypes of a total of 123 molar tissues...
February 20, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29453428/igf-i-and-igfbp-3-concentrations-at-2-years-associations-with-anthropometry-and-milk-consumption-in-an-indian-cohort
#7
Andrea S Wiley, Suyog M Joshi, Himangi G Lubree, Dattatray S Bhat, Neelam S Memane, Deepa A Raut, Chittaranjan S Yajnik
BACKGROUND/OBJECTIVES: To ascertain associations between plasma insulin-like growth factor I (IGF-I), insulin-like growth factor-binding protein 3 (IGFBP-3) and their molar ratio at 2 y with neonatal size, infant growth, body composition at 2 y, and feeding practices in an Indian cohort. SUBJECTS/METHODS: A cohort of 209 newborns, with 122 followed at 2 y. Anthropometry was conducted at birth and 2 y. IGF-I and IGFBP-3 concentrations were measured in cord blood and at 2 y...
February 16, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29451409/temporal-trends-in-incidence-and-outcome-of-hydatidiform-mole-a-retrospective-cohort-study
#8
Urika Joneborg, Yasin Folkvaljon, Nikos Papadogiannakis, Mats Lambe, Lena Marions
BACKGROUND: Reported incidence rates of hydatidiform mole (HM) show wide geographic and temporal variations, making reliable international comparisons difficult. The aim of the current study was to examine temporal trends in the incidence of HM and post-molar gestational trophoblastic neoplasia (GTN) in Stockholm County. MATERIAL AND METHODS: Data of all women with a diagnosis of HM in Stockholm County 1991-2010 was collected. The incidence of HM was assessed both in relation to number of births and viable conceptions (births and pregnancy terminations)...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29421928/a-case-of-partial-hydatidiform-molar-pregnancy-with-a-placental-diploid-triploid-mosaicism-associated-with-a-euploid-viable-foetus-complicated-with-severe-pre-eclampsia
#9
Sam Booth, Osama Eskandar
No abstract text is available yet for this article.
February 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29405964/new-insights-in-the-pathophysiology-of-complete-hydatidiform-mole
#10
Eric Jauniaux, Maria Memtsa, Jemma Johns, Jackie A Ross, Davor Jurkovic
OBJECTIVE: The majority of complete hydatidiform moles (CHM) are detected on ultrasound examination by the end of the first trimester when they present as multiple sonolucent cysts. To better understand the pathophysiology of this unique placental pathology and improve its prenatal diagnosis and management we have reviewed the ultrasound features of CHM before the appearance of cystic changes. STUDY DESIGN: We searched our database to identify all women diagnosed with a complete hydatidiform mole confirmed by histopathology who had an ultrasound examination before 9 weeks' gestation...
February 2018: Placenta
https://www.readbyqxmd.com/read/29379669/molar-pregnancy-in-cesarean-section-scar-a-case-report
#11
Elif Gülşah Dağdeviren, Rıza Dur, Erdem Fadıloğlu, Erhan Demirdağ, Çağatayhan Öztürk, Metin Altay
Cesarean scar ectopic pregnancies and molar pregnancies are two very rare obstetric pathologies. In both cases, serious morbidities are involved that require careful management. The coexistence of the two clinical conditions is far less common and there are a limited number of cases in the literature. In this case report, a 34-year-old patient with previous cesarean section was diagnosed as having a molar pregnancy in a cesarean scar through ultrasonography. The patient was asymptomatic at that time. Ultrasonography revealed a protruding mass at the cesarean section and her human chorionic gonadotropin level was measured as 59...
December 2017: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29375907/a-twin-pregnancy-with-a-hydatidiform-mole-and-a-coexisting-live-fetus-prenatal-diagnosis-treatment-and-follow-up
#12
Antonio Braga, Bruna Obeica, Heron Werner, Sue Yazaki Sun, Joffre Amim Júnior, Jorge Rezende Filho, Edward Araujo Júnior
Twin molar pregnancy with a hydatidiform mole and a coexisting live fetus is a rare form of gestational trophoblastic disease associated with an increased risk of obstetric complications and poor perinatal outcome. Prenatal diagnosis is essential for couple counseling and follow-up in Tertiary Reference Centers. Magnetic resonance imaging is important for the diagnostic differentiation of placental mesenchymal dysplasia and exclusion of myometrial invasion. Here we present a case of twin molar pregnancy with a hydatidiform mole and a coexisting live fetus diagnosed at gestational week 14 using two-dimensional (2D) and three-dimensional (3D) ultrasound and magnetic resonance imaging...
December 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29323809/case-report-of-an-ectopic-molar-pregnancy-in-the-presence-of-an-intrauterine-device
#13
Deborah A Simon, Angela L Smith, John R Holzhauer
BACKGROUND: Ectopic molar pregnancy is a rare phenomenon and has not been reported in the presence of an intrauterine device (IUD). Clinical diagnosis of molar pregnancy is challenging and requires careful follow-up. CASE: A 25-year-old woman (gravida 2, para 0) with a copper IUD in place presented with a positive pregnancy test. Diagnosis of the complete hydatidiform mole was pathologically confirmed after surgery following clinical and sonographic investigations that identified a left-sided ectopic pregnancy...
November 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29284889/anaesthetic-implications-of-severe-hyperthyroidism-secondary-to-molar-pregnancy-a-case-report-and-review-of-literature
#14
Srinivasan Swaminathan, Roshin Ann James, Rashmi Chandran, Reesha Joshi
Pregnant women with gestational trophoblastic disease have an increased likelihood to develop hyperthyroidism secondary to increased secretion of human chorionic gonadotropin. Most of these cases of hyperthyroidism remain undiagnosed and may present as a thyrotoxic crisis during the perioperative period. Pregnant patients with gestational trophoblastic disease should be always evaluated for hyperthyroidism, and in cases of severe hyperthyroidism, antithyroid treatment should be initiated before evacuation of the mole...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29278564/cystic-placentomegaly-on-a-second-trimester-ultrasound
#15
Heather P Adams, Jennifer Malloy
Placental mesenchymal dysplasia (PMD) is a rare disorder of the placenta characterized by placentomegaly, cystic vesicles, and dilated chorionic blood vessels. Clinically and pathologically, it closely resembles partial molar pregnancy and complete hydatidiform mole with a coexistent healthy fetus, both of which are associated with malignant trophoblastic disease. PMD, however, has no risk of malignant trophoblastic disease and can result in the birth of a normal fetus, highlighting the need for clinician awareness of PMD in order to avoid unnecessary termination of a viable and potentially healthy fetus...
January 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29241080/paternal-urinary-concentrations-of-organophosphate-flame-retardant-metabolites-fertility-measures-and-pregnancy-outcomes-among-couples-undergoing-in-vitro-fertilization
#16
Courtney C Carignan, Lidia Mínguez-Alarcón, Paige L Williams, John D Meeker, Heather M Stapleton, Craig M Butt, Thomas L Toth, Jennifer B Ford, Russ Hauser
BACKGROUND: Use of organophosphate flame retardants (PFRs) has increased over the past decade following the phase out of some brominated flame retardants, leading to increased human exposure. We recently reported that increasing maternal PFR exposure is associated with poorer pregnancy outcomes among women from a fertility clinic. Because a small epidemiologic study previously reported an inverse association between male PFR exposures and sperm motility, we sought to examine associations of paternal urinary concentrations of PFR metabolites and their partner's pregnancy outcomes...
February 2018: Environment International
https://www.readbyqxmd.com/read/29232272/relative-effects-of-age-race-and-stage-on-mortality-in-gestational-choriocarcinoma
#17
Christopher M Tarney, Chunqiao Tian, Eric R Craig, Barbara A Crothers, John K Chan, Glenn D Gist, Nicholas W Bateman, Thomas P Conrads, Chad A Hamilton, George Larry Maxwell, Kathleen M Darcy
OBJECTIVE: Gestational choriocarcinoma is a malignant form of gestational trophoblastic disease that usually arises after a molar pregnancy, but may follow any antecedent pregnancy. Investigations in this rare cancer are limited. We evaluated the prognostic effects of age, race, and stage in choriocarcinomas diagnosed for 4 decades. METHODS: Patients diagnosed as having gestational choriocarcinoma between 1973 and 2014 from the Surveillance, Epidemiology, and End Results program were eligible...
February 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29229282/what-is-the-optimal-duration-of-human-chorionic-gonadotrophin-surveillance-following-evacuation-of-a-molar-pregnancy-a-retrospective-analysis-on-over-20-000-consecutive-patients
#18
Christopher Coyle, Dee Short, Lauren Jackson, Neil J Sebire, Baljeet Kaur, Richard Harvey, Philip M Savage, Michael J Seckl
OBJECTIVE: To quantify the risk of developing post-molar gestational trophoblastic neoplasia (pGTN) beyond the first normal human chorionic gonadotrophin (hCG) in women who have had a complete (CHM) or partial molar pregnancy (PHM) and to re-evaluate the current UK Hydatidiform mole hCG surveillance guidelines. METHODS: The Charing Cross Hospital Trophoblast Disease Centre database was screened to identify all registered cases of hydatidiform mole (HM) between 1980 and 2009...
February 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29214637/identification-and-treatment-of-gestational-trophoblastic-neoplasia-located-in-the-cesarean-scar
#19
Xiaoyu Wang, Yuan Li, Junjun Yang, Yonglan He, Ming Wang, Xirun Wan, Yang Xiang
OBJECTIVE: To identify the clinical characteristics of, and the diagnostic and therapeutic strategies for, gestational trophoblastic neoplasia (GTN) located in the cesarean scar. METHODS: The present retrospective analysis was conducted among patients diagnosed with GTN located in the cesarean scar at Peking Union Medical College Hospital, Beijing, China, between June 1, 2006, and May 31, 2016. Clinical features, diagnostic and therapeutic procedures, and outcomes were reviewed...
December 6, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29072060/risk-factors-for-hydatidiform-mole-is-husband%C3%A2-s-job-a-major-risk-factor
#20
Hourieh Shamshiri Milani, Morteza Abdollahi, Sara Torbati, Taha Asbaghi, Eznollah Azargashb
Background: The hydatidiform mole (HM) is a precancerous placenta considered as a gestational trophoblastic disease (GTD). It may convert to more invasive forms of gestational trophoblastic neoplasia (GTN), endangering women’s health by more severe complications. Most GTN cases originate from HM, which is associated with uterine bleeding, preeclampsia and thyroid problems. Its etiology has not been adequately explored, but some risk factors have been reported. The aim of the present study was to assess any relationships between molar pregnancy and factors including mothers’ and husbands’ occupations...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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