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https://www.readbyqxmd.com/read/29452341/betadine-and-breast-implants
#1
Mark L Jewell, William P Adams
In the fourth quarter of 2017, the US FDA reviewed and approved a request by one of the breast implant manufacturers for a change in the Directions for Use (DFU) that removed warnings regarding the use of Betadine (povidone-iodine [PI] 10% solution, 1% available iodine [Purdue Frederick Company, Stamford, CT], also available in generic formulations [Aplicare, Inc., Meriden, CT]). Previously, in 2000, there were concerns by the FDA that PI would degrade the silicone elastomer shell. This change in the DFU represents an important advance that will benefit patients through the permitted use of PI to reduce the risk of bacterial contamination of implant surfaces...
February 14, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29452326/awake-microvascular-decompression-for-trigeminal-neuralgia-concept-and-initial-results
#2
Saleem I Abdulrauf, Jorge F Urquiaga, Ritesh Patel, J Andrew Albers, Varun B Sampat, Meghan Baumer, Eric Marvin, Matthew Pierson, Raquel Kragel, Jodi Walsh
OBJECTIVE: The option of performing MVD under awake anesthesia protocol ("awake" MVD) was examined in this initial series to assess whether intraoperative pain evaluation can identify and mitigate insufficient decompression of the trigeminal nerve, improving surgical outcomes. Additionally, "awake" MVD could expand procedure indications for those with comorbidities that would prohibit general endotracheal anesthesia (GEA). METHODS: An IRB-approved prospective study of 10 consecutive adults who underwent MVD for TN was conducted...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452193/antidepressant-activity-of-vorinostat-is-associated-with-amelioration-of-oxidative-stress-and-inflammation-in-a-corticosterone-induced-chronic-stress-model-in-mice
#3
Athira Kv, Rajaram Mohanrao Madhana, Indu Chandran Js, Mangala Lahkar, Swapnil Sinha, V G M Naidu
Major depressive disorder (MDD) is a multifactorial neuropsychiatric disorder. Chronic administration of corticosterone (CORT) to rodents is used to mimic the stress associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, a well-established feature found in depressive patients. Recently, preclinical studies have demonstrated the antidepressant potential of histone deacetylase (HDAC) inhibitors. So, we examined the antidepressant potential of vorinostat (VOR), a HDAC inhibitor against CORT injections in male mice...
February 13, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29452094/evolving-mechanisms-of-vascular-smooth-muscle-contraction-highlight-key-targets-in-vascular-disease
#4
REVIEW
Zhongwei Liu, Raouf A Khalil
Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function. Identifying the mechanisms of VSM contraction has been a major research goal in order to determine the causes of vascular dysfunction and exaggerated vasoconstriction in vascular disease. Major discoveries over several decades have helped to better understand the mechanisms of VSM contraction. Ca 2+ has been established as a major regulator of VSM contraction, and its sources, cytosolic levels, homeostatic mechanisms and subcellular distribution have been defined...
February 13, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29451456/clival-meningocele-causing-bilateral-hearing-loss-in-a-child-due-to-superficial-siderosis-of-the-central-nervous-system-case-report
#5
Stephen J Johans, Kevin N Swong, Daniel J Burkett, Michael P Wemhoff, Sean M Lew, Chirag R Patel, Anand V Germanwala
Superficial siderosis (SS) of the CNS is a rare and often unrecognized condition. Caused by hemosiderin deposition from chronic, repetitive hemorrhage in the subarachnoid space, it results in parenchymal damage in the subpial layers of the brain and spinal cord. T2-weighted MRI shows the characteristic hypointensity of hemosiderin deposition, classically occurring around the cerebellum, brainstem, and spinal cord. Patients present with progressive gait ataxia and sensorineural hearing impairment. Although there have been several studies, case reports, and review articles over the years, the clear pathophysiology of subarachnoid space hemorrhage remains to be elucidated...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29451320/commentary-on-the-ema-guideline-on-strategies-to-identify-and-mitigate-risks-for-first-in-human-and-early-clinical-trials-with-investigational-medicinal-products-emea-chmp-swp-28367-07-rev-1
#6
Joop van Gerven, Milton Bonelli
No abstract text is available yet for this article.
February 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29451037/esophageal-hiatal-hernia-risk-diagnosis-and-management
#7
Hai-Xiang Yu, Chun-Shan Han, Jin-Ru Xue, Zhi-Feng Han, Hua Xin
Esophageal hiatal hernia involves abnormal abdominal entry into thoracic cavity. It is classified based on orientation between esophageal junction and diaphragm. Sliding hiatal hernia (Type-I) comprises the most frequent category, emanating from right crus of diaphragm. Type-II esophageal hernia engages both left and right muscular crura. Type-III and IV additionally include the left crus. Age and increased body mass index are key risk factors, and congenital skeletal aberrations trigger pathogenesis through intestinal malrotations...
February 16, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29450772/dissolved-organic-matter-distribution-and-its-association-with-colloidal-aluminum-and-iron-in-the-selenga-river-basin-from-ulaanbaatar-to-lake-baikal
#8
Morimaru Kida, Orgilbold Myangan, Bolormaa Oyuntsetseg, Viacheslav Khakhinov, Masayuki Kawahigashi, Nobuhide Fujitake
The Selenga River Basin (Mongolia and Russia) has suffered from heavy metal contamination by placer gold mining and urban activities in recent decades. The objectives of this study were to provide the first distribution data of dissolved organic matter (DOM) and humic substances (HS) in this data-scarce region, and to investigate their association with dissolved and colloidal metals. Two sampling campaigns were conducted in August of 2013 and 2014. A constant proportion of HS (%HS; coefficient of variation of 2%) was observed from the headwater of Tuul River to the end of the delta before Lake Baikal, spanning > 1000 km in distance...
February 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29450659/social-factors-in-the-development-of-chronic-rhinosinusitis-a-systematic-review
#9
REVIEW
I Geramas, D Terzakis, E Hatzimanolis, C Georgalas
PURPOSE OF REVIEW: In an era where prevention is paramount, understanding social factors for chronic rhinosinusitis (CRS) may facilitate preventive interventions that mitigate risk factors associated with the initiation or progression of the disease. RECENT FINDINGS: Both passive and active smoking are clearly and unequivocally associated with both the incidence and the severity of rhinosinusitis, while there an increasing body of evidence linking social deprivation and low socioeconomic status with rhinosinusitis and its complications...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29450121/glyphosate-induced-toxicity-to-chickpea-plants-and-stress-alleviation-by-herbicide-tolerant-phosphate-solubilizing-burkholderia-cepacia-psbb1-carrying-multifarious-plant-growth-promoting-activities
#10
Mohammad Shahid, Mohd Saghir Khan
In this study, strain PSBB1 isolated from Vicia faba rhizosphere was identified as Burkholderia cepacia , by 16S rDNA sequence analysis and characterized. Strain PSBB1 tolerated glyphosate up to 3200 μg ml -1 and produced IAA (81.6 μg ml -1 ), ACC deaminase (69.3 mg -1 protein h -1 ), SA (39.3 μg ml -1 ) and 2,3-DHBA (26.6 μg ml -1 ), solubilized insoluble P (50.8 μg ml -1 ) and secreted 29.4 μg ml -1 exopolysaccharides, which decreased with increasing concentrations of glyphosate. Cell damage following glyphosate application was visible under SEM and CLSM...
February 2018: 3 Biotech
https://www.readbyqxmd.com/read/29449940/effects-of-fumaric-acid-supplementation-on-methane-production-and-rumen-fermentation-in-goats-fed-diets-varying-in-forage-and-concentrate-particle-size
#11
Zongjun Li, Nannan Liu, Yangchun Cao, Chunjia Jin, Fei Li, Chuanjiang Cai, Junhu Yao
Background: In rumen fermentation, fumaric acid (FA) could competitively utilize hydrogen with methanogenesis to enhance propionate production and suppress methane emission, but both effects were diet-dependent. This study aimed to explore the effects of FA supplementation on methanogenesis and rumen fermentation in goats fed diets varying in forage and concentrate particle size. Methods: Four rumen-cannulated goats were used in a 4 × 4 Latin square design with a 2 × 2 factorial arrangement of treatments: low or high ratio of forage particle size: concentrate particle size (Fps:Cps), without or with FA supplementation (24 g/d)...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29449812/calycosin-orchestrates-osteogenesis-of-danggui-buxue-tang-in-cultured-osteoblasts-evaluating-the-mechanism-of-action-by-omics-and-chemical-knock-out-methodologies
#12
Amy G W Gong, Ran Duan, Huai Y Wang, Tina T X Dong, Karl W K Tsim
Danggui Buxue Tang (DBT), an ancient Chinese herbal decoction commonly used to mitigate menopausal osteoporosis, contains two herbs: Astragali Radix (AR) and Angelicae Sinensis Radix (ASR). The exact efficacy of individual chemical(s) within DBT, or in any herbal mixture, is hard to be revealed. Calycosin and ferulic acid have been reported to be the predominant chemicals found within DBT, and its roles in regulating osteoblastic differentiation have been proposed here. To probe the roles of calycosin and ferulic acid, these chemicals were specifically depleted from the DBT extracts...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29449485/volatile-chemical-products-emerging-as-largest-petrochemical-source-of-urban-organic-emissions
#13
Brian C McDonald, Joost A de Gouw, Jessica B Gilman, Shantanu H Jathar, Ali Akherati, Christopher D Cappa, Jose L Jimenez, Julia Lee-Taylor, Patrick L Hayes, Stuart A McKeen, Yu Yan Cui, Si-Wan Kim, Drew R Gentner, Gabriel Isaacman-VanWertz, Allen H Goldstein, Robert A Harley, Gregory J Frost, James M Roberts, Thomas B Ryerson, Michael Trainer
A gap in emission inventories of urban volatile organic compound (VOC) sources, which contribute to regional ozone and aerosol burdens, has increased as transportation emissions in the United States and Europe have declined rapidly. A detailed mass balance demonstrates that the use of volatile chemical products (VCPs)-including pesticides, coatings, printing inks, adhesives, cleaning agents, and personal care products-now constitutes half of fossil fuel VOC emissions in industrialized cities. The high fraction of VCP emissions is consistent with observed urban outdoor and indoor air measurements...
February 16, 2018: Science
https://www.readbyqxmd.com/read/29449446/improving-accuracy-of-simultaneously-reconstructed-activity-and-attenuation-maps-using-deep-learning
#14
Donghwi Hwang, Kyeong Yun Kim, Seung Kwan Kang, Seongho Seo, Jin Chul Paeng, Dong Soo Lee, Jae Sung Lee
Simultaneous reconstruction of activity and attenuation using the maximum likelihood reconstruction of activity and attenuation (MLAA) augmented by time-of-flight (TOF) information is a promising method for positron emission tomography (PET) attenuation correction. However, it still suffers from several problems, including crosstalk artifacts, slow convergence speed, and noisy attenuation maps (μ-maps). In this work, we developed deep convolutional neural networks (CNNs) to overcome these MLAA limitations, and we verified their feasibility using a clinical brain PET data set...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29449273/novel-patient-centered-approach-to-facilitate-same-day-discharge-in-patients-undergoing-elective-percutaneous-coronary-intervention
#15
Amit P Amin, Patricia Crimmins-Reda, Samantha Miller, Brandon Rahn, Mary Caruso, Andrew Pierce, Brandy Dennis, Marissa Pendegraft, Katrine Sorensen, Howard I Kurz, John M Lasala, Alan Zajarias, Richard G Bach, Hemant Kulkarni, Jasvindar Singh
BACKGROUND: Same-day discharge (SDD) after elective percutaneous coronary intervention is safe, less costly, and preferred by patients, but it is usually performed in low-risk patients, if at all. To increase the appropriate use of SDD in more complex patients, we implemented a "patient-centered" protocol based on risk of complications at Barnes-Jewish Hospital. METHODS AND RESULTS: Our objectives were as follows: (1) to evaluate time trends in SDD; (2) to compare (a) mortality, bleeding, and acute kidney injury, (b) patient satisfaction, and (c) hospital costs by SDD versus no SDD (NSDD); and (3) to compare SDD eligibility by our patient-centered approach versus Society for Cardiovascular Angiography and Interventions guidelines...
February 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29449201/peer-coaching-through-mhealth-targeting-physical-activity-in-people-with-parkinson-disease-feasibility-study
#16
Cristina Colón-Semenza, Nancy K Latham, Lisa M Quintiliani, Terry D Ellis
BACKGROUND: Long-term engagement in exercise and physical activity mitigates the progression of disability and increases quality of life in people with Parkinson disease (PD). Despite this, the vast majority of individuals with PD are sedentary. There is a critical need for a feasible, safe, acceptable, and effective method to assist those with PD to engage in active lifestyles. Peer coaching through mobile health (mHealth) may be a viable approach. OBJECTIVE: The purpose of this study was to develop a PD-specific peer coach training program and a remote peer-mentored walking program using mHealth technology with the goal of increasing physical activity in persons with PD...
February 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29449119/violence-against-health-care-providers-a-mixed-methods-study-from-karachi-pakistan
#17
Lubna Ansari Baig, Shiraz Shaikh, Maciej Polkowski, Syeda Kausar Ali, Seemin Jamali, Lubna Mazharullah, Marium Soomro, Bhavita Kumari, Sobia Memon, Greesh Maheshwari, Saleema Arif
BACKGROUND: Violence against health care providers (HCPs) remains a significant public health problem in developing countries, affecting their performance and motivation. OBJECTIVES: To report the quantity and perceived causes of violence committed upon HCPs and identify strategies intended to prevent and de-escalate it. METHODS: This was a mixed-methods concurrent study design (QUAN-QUAL). A structured questionnaire was filled in on-site by trained data collectors for quantitative study...
February 12, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29449097/-the-unhealthy-other-how-vaccine-rejecting-parents-construct-the-vaccinating-mainstream
#18
Katie Attwell, David T Smith, Paul R Ward
To address the phenomenon of vaccine hesitancy and rejection, researchers increasingly recognise the need to engage with the social context of parents' decision-making. This study examines how vaccine rejecting parents socially construct the vaccinating mainstream in opposition to themselves. We analyse qualitative data from interviews with parents in Adelaide, South Australia. Applying insights from Social Identity Theory (SIT), we show how these parents bolster their own sense of identity and self-belief by employing a discourse that casts vaccinators as an Unhealthy Other...
February 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29448923/data-driven-predictions-and-novel-hypotheses-about-zoonotic-tick-vectors-from-the-genus-ixodes
#19
Laura Hyesung Yang, Barbara A Han
BACKGROUND: With the resurgence of tick-borne diseases such as Lyme disease and the emergence of new tick-borne pathogens such as Powassan virus, understanding what distinguishes vectors from non-vectors, and predicting undiscovered tick vectors is a crucial step towards mitigating disease risk in humans. We aimed to identify intrinsic traits that predict which Ixodes tick species are confirmed or strongly suspected to be vectors of zoonotic pathogens. METHODS: We focused on the well-studied tick genus Ixodes from which many species are known to transmit zoonotic diseases to humans...
February 15, 2018: BMC Ecology
https://www.readbyqxmd.com/read/29448153/projecting-future-climate-change-impacts-on-heat-related-mortality-in-large-urban-areas-in-china
#20
Ying Li, Ting Ren, Patrick L Kinney, Andrew Joyner, Wei Zhang
Global climate change is anticipated to raise overall temperatures and has the potential to increase future mortality attributable to heat. Urban areas are particularly vulnerable to heat because of high concentrations of susceptible people. As the world's largest developing country, China has experienced noticeable changes in climate, partially evidenced by frequent occurrence of extreme heat in urban areas, which could expose millions of residents to summer heat stress that may result in increased health risk, including mortality...
February 12, 2018: Environmental Research
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