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https://www.readbyqxmd.com/read/28445846/a-sharp-robust-and-quantitative-method-by-liquid-chromatography-tandem-mass-spectrometry-for-the-measurement-of-ead-for-acute-radiation-syndrome-and-its-application
#1
Yiwei Zhang, Jian Li, Zhiyun Meng, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Zhuona Wu, Ying Zheng, Jinbin Wei, Guifang Dou
17-Ethinyl-3,17-dihydroxyandrost-5-ene (EAD) is an agent designed for the treatment of acute radiation syndrome (ARS). Given its vital role played in the prevention and mitigation of ARS, the development of a sharp, sensitive and robust liquid chromatography tandem mass spectrometry (LC-MS/MS) method to monitor the metabolism of EAD in vivo was crucial. A new method was constructed and validated for the determination of EAD with the internal standard of androst-5-ene-3β,17β-diol (5-AED). The blood samples were precipitated with methanol, centrifuged, from which the supernatant was separated on UPLC with C18 column and eluted in gradient with acetonitrile and Milli-Q water both containing 0...
April 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28445824/the-shadow-price-of-co2-emissions-in-china-s-iron-and-steel-industry
#2
Ke Wang, Linan Che, Chunbo Ma, Yi-Ming Wei
As China becomes the world's largest energy consumer and CO2 emitter, there has been a rapidly emerging literature on estimating China's abatement cost for CO2 using a distance function approach. However, the existing studies have mostly focused on the cost estimates at macro levels (provinces or industries) with few examining firm-level abatement costs. No work has attempted to estimate the abatement cost of CO2 emissions in the iron and steel industry. Although some have argued that the directional distance function (DDF) is more appropriate in the presence of bad output under regulation, the choice of directions is largely arbitrary...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28445430/impact-of-land-use-on-pm2-5-pollution-in-a-representative-city-of-middle-china
#3
Haiou Yang, Wenbo Chen, Zhaofeng Liang
Fine particulate matter (PM2.5) pollution has become one of the greatest urban issues in China. Studies have shown that PM2.5 pollution is strongly related to the land use pattern at the micro-scale and optimizing the land use pattern has been suggested as an approach to mitigate PM2.5 pollution. However, there are only a few researches analyzing the effect of land use on PM2.5 pollution. This paper employed land use regression (LUR) models and statistical analysis to explore the effect of land use on PM2.5 pollution in urban areas...
April 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28445088/predicting-the-need-for-third-line-antiretroviral-therapy-by-identifying-patients-at-high-risk-for-failing-second-line-antiretroviral-therapy-in-south-africa
#4
Dorina Onoya, Cornelius Nattey, Eric Budgell, Liudmyla van den Berg, Mhairi Maskew, Denise Evans, Kamban Hirasen, Lawrence C Long, Matthew P Fox
Although third-line antiretroviral therapy (ART) is available in South Africa's public sector, its cost is substantially higher than first and second line. Identifying risk factors for failure on second-line treatment remains crucial to reduce the need for third-line drugs. We conducted a case-control study including 194 adult patients (≥18 years; 70 cases and 124 controls) who initiated second-line ART in Johannesburg, South Africa. Unconditional logistic regression was used to assess predictors of virologic failure (defined as 2 consecutive viral load measures ≥1000 copies/mL, ≥3 months after switching to second line)...
April 26, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28445068/experimental-demonstration-of-230%C3%A2-phase-modulation-in-gate-tunable-graphene-gold-reconfigurable-mid-infrared-metasurfaces
#5
Michelle C Sherrott, Philip W C Hon, Katherine T Fountaine, Juan C Garcia, Samuel M Ponti, Victor Watson Brar, Luke A Sweatlock, Harry A Atwater
Metasurfaces offer significant potential to control far-field light propagation through the engineering of amplitude, polarization, and phase at an interface. We report here phase modulation of an electronically reconfigurable metasurface and demonstrate its utility for mid-infrared beam steering. Using a gate-tunable graphene-gold resonator geometry, we demonstrate highly tunable reflected phase at multiple wavelengths and show up to 237° phase modulation range at an operating wavelength of 8.50 μm. We observe a smooth monotonic modulation of phase with applied voltage from 0° to 206° at a wavelength of 8...
April 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28445048/molecularly-tailored-nickel-precursor-and-support-yield-a-stable-methane-dry-reforming-catalyst-with-superior-metal-utilization
#6
Tigran Margossian, Kim Larmier, Sung Min Kim, Frank Krumeich, Alexey Fedorov, Peter Chen, Christoph Mueller, Christophe Copéret
Syngas production via the Dry Reforming of Methane (DRM) is a highly endothermic process conducted under harsh conditions, hence the main difficulty resides in generating stable catalysts. This can in principle be achieved by reducing coke formation, sintering and loss of metal through diffusion in the support. [{Ni(μ2-OCHO)(OCHO)(tmeda)}2(μ2-OH2)], readily synthesized and soluble in a broad range of solvents, was developed as a molecular precursor to form pure 2 nm Ni(0) nanoparticles on alumina, the commonly used support in DRM...
April 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28444629/stress-measured-by-allostatic-load-score-varies-by-reason-for-immigration-the-africans-in-america-study
#7
Jean N Utumatwishima, Rafeal L Baker, Brianna A Bingham, Stephanie T Chung, David Berrigan, Anne E Sumner
OBJECTIVE: Reason for immigration as a biological stress has not been studied in Africans. Our goal was to determine in African immigrants, if biological stress measured by allostatic load score (ALS) varies by reason for immigration. METHODS: Using an ALS which had been previously developed with the National Health and Nutrition Examination Survey (NHANES) data to assess stress due to racism and nativity, ALS was calculated in 85 African immigrants (67% male, age 42 ± 10 years)...
April 25, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28444607/the-provision-of-spiritual-care-in-hospices-a-study-in-four-hospices-in-north-rhine-westphalia
#8
Andreas Walker, Christof Breitsameter
This article considers the role and the practices of spiritual care in hospices. While spiritual care was firmly established as one of the four pillars of practical hospice care alongside medical, psychological and social care by Cicely Saunders, the importance and functions of spiritual care in daily practice remain arguable. When speaking about spirituality, what are we actually speaking about? What form do the spiritual relations take between full-time staff and volunteers on the one hand, and the patients and their family members on the other? These were central questions of a qualitative study that we carried out in four hospices in North Rhine-Westphalia, Germany, to explore how spiritual care is provided in hospices and what significance spirituality has in hospices...
April 25, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28444603/physiological-functioning-of-lagerstroemia-speciosa-l-under-heavy-roadside-traffic-an-approach-to-screen-potential-species-for-abatement-of-urban-air-pollution
#9
H Singh, Savita, R Sharma, S Sinha, M Kumar, P Kumar, A Verma, S K Sharma
The mitigation potential of avenue tree species needs a sound understanding, especially for landscape planning or planting tree species on roadside, especially in city limits where there is huge traffic due to more number of vehicles. A preliminary study was conducted to investigate the impact of heavy traffic movement and pollution thereof on physiological functioning of Lagerstroemia speciosa trees planted on roadside in terms of carbon absorption, mitigation potential and adaptive behavior. Trees on roadside exhibited reduced carbon assimilation (36...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28444504/correction-of-parallel-transmission-using-concurrent-rf-and-gradient-field-monitoring
#10
Mustafa Çavuşoğlu, Benjamin Emanuel Dietrich, David Otto Brunner, Markus Weiger, Klaas Paul Pruessmann
OBJECTIVES: The accuracy and precision of the parallel RF excitations are highly dependent on the spatial and temporal fidelity of the magnetic fields involved in spin excitation. The consistency between the nominal and effective fields is typically limited by the imperfections of the employed hardware existing both in the gradient system and the RF chain. In this work, we experimentally presented highly improved spatially tailored parallel excitations by turning the native hardware accuracy challenge into a measurement and control problem using an advanced field camera technology to fully correct parallel RF transmission experiment...
April 25, 2017: Magma
https://www.readbyqxmd.com/read/28444314/cold-disinfestation-of-hass-avocado-persia-americana-of-three-species-of-fruit-fly-diptera-tephritidae-ceratitis-capitata-ceratitis-rosa-and-ceratitis-cosyra
#11
A B Ware, C L N du Toit
The avocado industry is important in South Africa, but access to certain markets is impeded by the presence of phytosanitary pests. One of the ways of securing entry to these markets is to demonstrate that a mitigating treatment will result in there being a negligible chance of accidental importation. In cold treatment comparative studies at 0 °C and 2 °C of immature stages of Ceratitis capitata (Wiedemann), Ceratitis rosa Karsch, and Ceratitis cosyra (Walker) in "Hass" avocado, the third instar of C...
April 21, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28444240/non-specific-effects-of-oral-polio-vaccine-on-diarrheal-burden-and-etiology-among-bangladeshi-infants
#12
Alexander Upfill-Brown, Mami Taniuchi, James A Platts-Mills, Beth Kirkpatrick, Stacey L Burgess, M Steven Oberste, William Weldon, Eric Houpt, Rashidul Haque, K Zaman, William A Petri
Background: As the global polio eradication initiative prepares to cease use of oral polio vaccine (OPV) in 2020, there is increasing interest in understanding if oral vaccination provides non-specific immunity to other infections so that the consequences of this transition can be effectively planned for and mitigated. Methods: Data was collected from infants in an urban slum in Bangladesh (Mirpur, Dhaka) as part of the PROVIDE study. Following vaccination with tOPV at 6,10, and 14 weeks, infants were randomly assigned to receive tOPV (n=315) or IPV (n=299) at 39 weeks...
April 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28444166/the-effect-of-a-piperacillin-tazobactam-shortage-on-antimicrobial-prescribing-and-clostridium-difficile-risk-in-88-u-s-medical-centers
#13
Alan E Gross, Richard S Johannes, Vikas Gupta, Ying P Tabak, Arjun Srinivasan, Susan C Bleasdale
Background: Anti-infective shortages are a pervasive problem in the U.S. The objective of this study was to identify any associations between changes in antibiotic prescribing during a piperacillin/tazobactam (PIP/TAZO) shortage and hospital-onset Clostridium difficile infection (HO-CDI) risk in 88 U.S medical centers. Methods: We analyzed electronically captured microbiology and antibiotic use data from a network of U.S. hospitals from July 2014 through June 2015...
April 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28444060/-personal-and-social-factors-that-influence-subjective-well-being-socioeconomic-differences
#14
Tania Gaspar, Leonor Balancho
The main objective is to study the relation and impact of Socioeconomic Status (SES) on the subjective well-being in children and adolescents and the role of social and personal factors in this relation. Data was collected in 16 schools; 8 in the North and 8 in the Lisbon Region of Portugal. The questionnaires were filled out by 1,181 youths, 51.5% of which were female. Ages ranged between 8 and 17, the girl's average age being 9.8 years (SD = 1.32) and the boy's average age being 10.0 (SD = 1.53); 2.6% of young people had special educational needs, and 3% did not use the Portuguese language at home; 12...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444003/species-abundance-and-temporal-variation-of-arbovirus-vectors-in-brownsville-texas
#15
Krithika Srinivasan, Beatriz Tapia, Arturo Rodriguez, Robert Wood, Jennifer J Salinas
The recent outbreaks of the dengue fever and West Nile viruses and the looming threats of the Zika and chikungunya viruses highlight the importance of establishing effective, proactive arboviral surveillance in communities at high risk of transmission, such as those on the Texas-Mexico border. Currently, there are no approved human vaccines available for these mosquito-borne diseases, so entomological control and case management are the only known methods for decreasing disease incidence. The principal vectors, which include Culex quinquefasciatus, Aedes aegypti, and Ae...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28443371/solutions-to-address-diabetes-related-financial-burden-and-cost-related-nonadherence-results-from-a-pilot-study
#16
Minal R Patel, Kenneth Resnicow, Ian Lang, Kathleen Kraus, Michele Heisler
BACKGROUND: Cost-related nonadherence (CRN) to recommended self-management behaviors among adults with chronic conditions such as diabetes is prevalent. Few behavioral interventions to mitigate CRN have been tested and evaluated. AIMS: We developed a financial burden resource tool and examined its acceptability and the preliminary effects on patient-centered outcomes among adults with diabetes or prediabetes seen in a clinical setting. METHOD: We report a pre-post one-group design pilot study...
April 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28443254/perfluoroalkyl-substances-exposure-and-thyroid-hormones-in-humans-epidemiological-observations-and-implications
#17
REVIEW
Jung Eun Lee, Kyungho Choi
Thyroid hormones play crucial roles in normal neurodevelopment of fetus and child. Many chemicals can affect control and homeostasis of thyroid hormones, and eventually lead to various adverse health effects including neurodevelopmental disorders. Perfluoroalkyl substances (PFASs) are among the thyroid disrupting chemicals that can be encountered among general human population. Due to their unique physicochemical characteristics, PFASs have been used as surfactants and surface coating materials in many applications...
March 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28443069/long-term-enrichment-of-stress-tolerant-cellulolytic-soil-populations-following-timber-harvesting-evidenced-by-multi-omic-stable-isotope-probing
#18
Roland C Wilhelm, Erick Cardenas, Hilary Leung, András Szeitz, Lionel D Jensen, William W Mohn
Soil management is vital for maintaining the productivity of commercial forests, yet the long-term impact of timber harvesting on soil microbial communities remains largely a matter of conjecture. Decomposition of plant biomass, comprised mainly of lignocellulose, has a broad impact on nutrient cycling, microbial activity and physicochemical characteristics of soil. At "Long-term Soil Productivity Study" sites in California dominated by Ponderosa pine, we tested whether clear-cut timber harvesting, accompanied by varying degrees of organic matter (OM) removal, affected the activity and structure of the cellulose-degrading microbial populations 16 years after harvesting...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28443046/craving-behavior-intervention-in-ameliorating-college-students-internet-game-disorder-a-longitudinal-study
#19
Lin-Yuan Deng, Lu Liu, Cui-Cui Xia, Jing Lan, Jin-Tao Zhang, Xiao-Yi Fang
Craving, as a central feature of addiction and a precursor of relapse, is targeted recently in addiction intervention. While Internet gaming disorder (IGD), conceptualized as a behavioral addiction, is lack of effective treatment practice and exploration of its mechanism. This research aims to test the effectiveness and detect the active ingredients of craving behavior intervention (CBI) in mitigation of IGD among young adults. A total of 63 male college students with IGD were assigned into the intervention group (six-session CBI intervention) or the waiting-list control group...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28442888/new-developments-in-the-treatment-of-multiple-myeloma-clinical-utility-of-daratumumab
#20
REVIEW
Cian McEllistrim, Janusz Krawczyk, Michael E O'Dwyer
Multiple myeloma is a clonal disorder of plasma cells that is currently considered incurable. CD38 is a 46 kDa type II transmembrane glycoprotein that is highly expressed on myeloma cells. Daratumumab is a first in-class human IgG1 monoclonal antibody that targets CD38, and has antimyeloma effects through several mechanisms. Single-agent trials show surprising activity in heavily pretreated myeloma patients. Trials in the relapsed setting, where daratumumab is added to lenalidomide and dexamethasone or bortezomib and dexamethasone, have demonstrated significantly improved progression-free survival with acceptable toxicity...
2017: Biologics: Targets & Therapy
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