keyword
MENU ▼
Read by QxMD icon Read
search

mitigation

keyword
https://www.readbyqxmd.com/read/29050313/adipose-derived-mesenchymal-stem-cells-employed-exosomes-to-attenuate-aki-ckd-transition-through-tubular-epithelial-cell-dependent-sox9-activation
#1
Fengming Zhu, Octavia L S Chong Lee Shin, Guangchang Pei, Zhizhi Hu, Juan Yang, Han Zhu, Meng Wang, Jingyi Mou, Jie Sun, Yuxi Wang, Qian Yang, Zhi Zhao, Huzi Xu, Hui Gao, Weiqi Yao, Xiao Luo, Wenhui Liao, Gang Xu, Rui Zeng, Ying Yao
Acute kidney injury (AKI) predisposes patients to an increased risk into progressive chronic kidney disease (CKD), however effective treatments are still elusive. This study aimed to investigate the therapeutic efficacy of human adipose-derived MSCs (hAD-MSCs) in the prevention of AKI-CKD transition, and illuminate the role of Sox9, a vital transcription factor in the development of kidney, in this process. C57BL/6 mice were subjected to unilateral renal ischemia/reperfusion (I/R) with or without hAD-MSC treatment...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049912/globular-chitosan-treatment-of-bovine-jugular-veins-evidence-of-anticalcification-efficacy-in-the-subcutaneous-rat-model
#2
Anna A Krasilnikova, David S Sergeevichev, Vladislav V Fomenko, Alexander A Korobeynikov, Maria B Vasilyeva, Alexander S Yunoshev, Alexander M Karaskov, Evgeny A Pokushalov
Vascular xenografts are widely used in cardiovascular surgery as an alternative to autologous vessels and vascular allografts. Calcification is one of the main drawbacks of vascular grafts, especially among young patients and children. Among different anticalcification approaches, chitosan emerges as a highly promising candidate due to its versatility, natural origin, and biocompatibility. We investigated the anticalcification efficacy of globular chitosan ("Chitozol") as it demonstrated the improved rate of water solubility as compared with conventional linear macromolecules of chitosan...
September 14, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29049385/correction-short-term-in-situ-shading-effectively-mitigates-linear-progression-of-coral-killing-sponge-terpios-hoshinota
#3
Thangadurai Thinesh, Ramu Meenatchi, Ramasamy Pasiyappazham, Polpass Arul Jose, Muthamizh Selvan, George Seghal Kiran, Joseph Selvin
[This corrects the article DOI: 10.1371/journal.pone.0182365.].
2017: PloS One
https://www.readbyqxmd.com/read/29049334/exams-disadvantage-women-in-introductory-biology
#4
Cissy J Ballen, Shima Salehi, Sehoya Cotner
The gender gap in STEM fields has prompted a great deal of discussion, but what factors underlie performance deficits remain poorly understood. We show that female students underperformed on exams compared to their male counterparts across ten large introductory biology course sections in fall 2016 (N > 1500 students). Females also reported higher levels of test anxiety and course-relevant science interest. Results from mediation analyses revealed an intriguing pattern: for female students only, and regardless of their academic standing, test anxiety negatively impacted exam performance, while interest in the course-specific science topics increased exam performance...
2017: PloS One
https://www.readbyqxmd.com/read/29049078/hearts-and-minds-real-life-cardiotoxicity-with-clozapine-in-psychosis
#5
George Joy, Eromona Whiskey, Mark Bolstridge, Alejandro Porras-Segovia, Theresa A McDonagh, Carla M Plymen, Sukhi S Shergill
BACKGROUND: Schizophrenia has a 1% prevalence in the population; 30% of these patients are treatment refractory. Clozapine is the only drug licensed to treat treatment refractory psychosis, but concerns about potential adverse effects result in only a proportion of eligible patients being treated. Although a well-documented neutropenia risk is mitigated by routine blood testing, cardiac toxicity is a commonly cited reason to discontinue clozapine treatment. However, there is little data on the real-life cardiac outcomes in those receiving clozapine treatment...
October 19, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29049076/fatigue-risk-management-the-impact-of-anesthesiology-residents-work-schedules-on-job-performance-and-a-review-of-potential-countermeasures
#6
Lily R Wong, Erin Flynn-Evans, Keith J Ruskin
Long duty periods and overnight call shifts impair physicians' performance on measures of vigilance, psychomotor functioning, alertness, and mood. Anesthesiology residents typically work between 64 and 70 hours per week and are often required to work 24 hours or overnight shifts, sometimes taking call every third night. Mitigating the effects of sleep loss, circadian misalignment, and sleep inertia requires an understanding of the relationship among work schedules, fatigue, and job performance. This article reviews the current Accreditation Council for Graduate Medical Education guidelines for resident duty hours, examines how anesthesiologists' work schedules can affect job performance, and discusses the ramifications of overnight and prolonged duty hours on patient safety and resident well-being...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29049045/nutrition-physical-activity-and-lifestyle-factors-in-prostate-cancer-prevention
#7
Eric Ballon-Landa, John Kellogg Parsons
PURPOSE OF REVIEW: To review current evidence for prostate cancer prevention with nutrition, physical activity, and lifestyle interventions and identify future research directions. RECENT FINDINGS: Multiple preclinical and observational studies have observed that diet, exercise, and lifestyle interventions may play a role in mitigating disease progression, mortality, and overall disease burden for high-grade and fatal prostate cancer. Increased vegetable and fruit intakes, decreased red meat and saturated fat intakes, and increased exercise are potentially associated with decreased risk of incident disease and increased progression-free, prostate cancer-specific, and overall survival...
October 18, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29048724/longitudinal-perspectives-on-the-psychosis-spectrum-in-22q11-2-deletion-syndrome
#8
REVIEW
Sunny X Tang, Raquel E Gur
The prevalence of psychotic disorders in individuals with 22q11.2 Deletion Syndrome (22q11DS) reaches 25-35% in young adulthood and may provide a neurogenetic model for clinical risk of psychotic disorders in the general population. This review focuses on prospective longitudinal studies in 22q11DS, which capture fluctuations in psychosis symptoms over time and may provide insights into potential demographic, clinical, cognitive, and neuroimaging predictors of psychosis-spectrum outcomes in the general population...
October 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29048714/high-genetic-risk-scores-for-impaired-insulin-secretory-capacity-doubles-the-risk-for-type-2-diabetes-in-asians-and-is-exacerbated-by-western-type-diets
#9
Da Sol Kim, Byoung Chul Kim, James W Daily, Sunmin Park
BACKGROUND: Asians have among the highest incidence of type 2 diabetes (T2DM) in the world, partly due to low β-cell function, causing them to rapidly develop T2DM when insulin resistant. This study tested the hypothesis that genetic polymorphisms are responsible for the low β-cell function and that dietary factors interact with the genes to exacerbate their risk of T2DM. METHODS: We selected 10 genetic variants of 5 genes involved in insulin secretion (CDKAL1, KCNQ1, IDE, HHEX, and ABCA1) from the genome-wide association studies to calculate the genetic risk scores (GRSs) in 8842 Korean adults in the Ansan/Ansung cohort in the Korean Genome Epidemiology Study...
September 5, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29048609/two-novel-atypical-pkc-inhibitors-acpd-and-dnda-effectively-mitigate-cell-proliferation-and-epithelial-to-mesenchymal-transition-of-metastatic-melanoma-while-inducing-apoptosis
#10
Wishrawana S Ratnayake, André H Apostolatos, David A Ostrov, Mildred Acevedo-Duncan
Atypical protein kinase Cs (aPKC) are involved in cell cycle progression, tumorigenesis, cell survival and migration in many cancers. We believe that aPKCs play an important role in cell motility of melanoma by regulating cell signaling pathways and inducing epithelial to mesenchymal transition (EMT). We have investigated the effects of two novel aPKC inhibitors; 2-acetyl-1,3-cyclopentanedione (ACPD) and 3,4-diaminonaphthalene-2,7-disulfonic acid (DNDA) on cell proliferation, apoptosis, migration and invasion of two malignant melanoma cell lines compared to normal melanocytes...
September 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29048287/legionella-pneumophila-serogroup-1-in-the-water-facilities-of-a-tertiary-healthcare-center-india
#11
Rama Chaudhry, K Sreenath, Valavane Arvind, E V Vinayaraj, Sagar Tanu
Proactive environmental surveillance for Legionella pneumophila in hospitals that treat immunocompromised patients is a useful strategy for preventing nosocomial Legionnaires' disease. We report the presence of L. pneumophila serogroup 1 in 15.2% of the water systems of our tertiary healthcare center, which should prompt health officials to formulate mitigation policies.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29048216/thermal-response-to-high-power-holmium-laser-lithotripsy
#12
Ali H Aldoukhi, Khurshid R Ghani, Timothy L Hall, William W Roberts
OBJECTIVES: The aim of this study was to investigate "calyceal" fluid temperature changes during holmium laser activation/lithotripsy using settings up to 40 watt power output with different irrigation flow rates. METHODS: The experimental system consisted of a glass test tube (diameter 10 mm/length 75 mm) filled with deionized water, to mimic a calyx. Real time temperature was recorded using a thermocouple (Physitemp, NJ) positioned 5 mm from the bottom of the tube...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29048016/affordable-dispersion-mitigation-method-for-the-next-generation-rf-over-fiber-optical-channels
#13
Shalom Bloch, Shmuel Sternklar, Er'el Granot
Next-generation analog radio frequency over fiber (RFoF) links will require dispersion compensation. Most dispersion compensation methods are based on additional optical elements. Therefore, these solutions may be inadequate for low-cost channels. In this work, we suggest a novel low-cost dispersion compensation solution for RFoF links. The method is based on two properties, which are common in these links: the modulation depth in analog RFoF links is lower than in digital links (and to avoid nonlinearities, it may be deliberately set to a small value), and the data are carried by a high-frequency carrier...
August 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047877/high-speed-combustion-diagnostics-in-a-rapid-compression-machine-by-broadband-supercontinuum-absorption-spectroscopy
#14
Thomas Werblinski, Peter Fendt, Lars Zigan, Stefan Will
The first results under fired internal combustion engine conditions based on a supercontinuum absorption spectrometer are presented and discussed. Temperature, pressure, and water mole fraction are inferred simultaneously from broadband H2O absorbance spectra ranging from 1340 nm to 1440 nm. The auto-ignition combustion process is monitored for two premixed n-heptane/air mixtures with 10 kHz in a rapid compression machine. Pressure and temperature levels during combustion exceed 65 bar and 1900 K, respectively...
May 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047609/optically-coherent-image-formation-and-denoising-using-a-plug-and-play-inversion-framework
#15
Casey J Pellizzari, Russell Trahan, Hanying Zhou, Skip Williams, Stacie E Williams, Bijan Nemati, Michael Shao, Charles A Bouman
The performance of optically coherent imaging systems can be limited by measurement and speckle noise. In this paper, we develop an image formation framework for computing the maximum a posteriori estimate of an object's reflectivity when imaged using coherent illumination and detection. The proposed approach allows for the use of Gaussian denoising algorithms (GDAs), without modification, to mitigate the exponentially distributed and signal-dependent noise that occurs in coherent imaging. Several GDAs are compared using both simulated and experimental data...
June 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047495/minimum-variance-control-for-mitigation-of-vibrations-in-adaptive-optics-systems
#16
Pedro Escárate, Rodrigo Carvajal, Laird Close, Jared Males, Katie Morzinski, Juan C Agüero
In this paper, we address the design of a minimum variance controller (MVC) for the mitigation of vibrations in modern telescope adaptive optics (AO) systems. It is widely accepted that a main source of non-turbulent perturbations is the mechanical resonance induced by the wind or the instrumentation systems, such as fans and cooling pumps. To adequately mitigate vibrations, the application of frequency-based controllers has been considered in the past decade. In this work, we express the system model in terms of the tracking of a zero-input signal via the MVC...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047226/babies-in-boxes-and-the-missing-links-on-safe-sleep-human-evolution-and-cultural-revolution
#17
REVIEW
Melissa Bartick, Cecília Tomori, Helen L Ball
Concerns about bedsharing as a risk for sudden infant death syndrome and other forms of sleep-associated infant death have gained prominence as a public health issue. Cardboard "baby boxes" are increasingly promoted to prevent infant death through separate sleep, despite no proof of efficacy. However, baby boxes disrupt "breastsleeping" (breastfeeding with co-sleeping) and may undermine breastfeeding. Recommendations enforcing separate sleep are based on 20th century Euro-American social norms for solitary infant sleep and scheduled feedings via bottles of cow's milk-based formula, in contrast to breastsleeping, an evolutionary adaptation facilitating the survival of mammalian infants for millennia...
October 18, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29047163/from-job-stress-to-intention-to-leave-among-hospital-nurses-a-structural-equation-modelling-approach
#18
Wen-Yen Lo, Li-Yin Chien, Fang-Ming Hwang, Nicole Huang, Shu-Ti Chiou
AIMS: To examine the structural relationships linking job stress to leaving intentions through job satisfaction, depressed mood and stress adaptation among hospital nurses. BACKGROUND: High turnover among nurses is a global concern. Structural relationships linking job stress to leaving intentions have not been thoroughly examined. DESIGN: Two nationwide cross-sectional surveys of full-time hospital staff in 2011 and 2014. METHODS: The study participants were 26,945 and 19,386 full-time clinical nurses in 2011 and 2014, respectively...
October 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29047162/baicalin-protects-h9c2-cardiomyocytes-against-hypoxia-reoxygenation-induced-apoptosis-and-oxidative-stress-through-activation-of-mitochondrial-aldehyde-dehydrogenase-2
#19
Wen-Bin Jiang, Wei Zhao, Hao Chen, You-Yang Wu, Yi Wang, Guo-Sheng Fu, Xiang-Jun Yang
Baicalin, a flavonoid glycoside separated from Scutellaria baicalensis, has cardioprotection against ischemia/reperfusion (I/R) injury. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is considered as an endogenous protective mechanism against I/R injury depending on its antioxidant and antiapoptotic characteristics. Herein, the present study demonstrate whether ALDH2 contributes to the cardioprotection of baicalin against hypoxia/reoxygenation (H/R)-inudced H9c2 cardiomyocytes injury. Our results observed that H/R treatment resulted in a significant decrease in cells viability and obvious increases in caspase-3 activity and apoptosis rate in H9c2 cells, while these alterations were evidently reversed by baicalin pretreatment...
October 19, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29047156/cyclophosphamide-induced-male-subfertility-in-mice-an-assessment-of-the-potential-benefits-of-maca-supplement
#20
A Y Onaolapo, B P Oladipo, O J Onaolapo
Effects of Lepidium meyenii (Maca) on cyclophosphamide (CYP)-induced gonadal toxicity in male mice were investigated. Mice were assigned to six treatment groups: Vehicle control, CYP control, CYP plus oral Maca (500 or 1,000 mg/kg), and oral Maca (500 or 1,000 mg/kg). CYP was administered via the intraperitoneal route (days 1-2), while vehicle or Maca were administered daily for 28 days. On day 28, half of the animals in each group were either sacrificed or paired with age-matched females for fertility assessment...
October 18, 2017: Andrologia
keyword
keyword
78368
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"