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https://www.readbyqxmd.com/read/28796812/toxicological-and-bio-distribution-profile-of-a-gm-csf-expressing-double-targeted-chimeric-oncolytic-adenovirus-oncos-102-support-for-clinical-studies-on-advanced-cancer-treatment
#1
Lukasz Kuryk, Lotta Vassilev, Tuuli Ranki, Akseli Hemminki, Aila Karioja-Kallio, Onerva Levälampi, Antti Vuolanto, Vincenzo Cerullo, Sari Pesonen
The purpose of this work was to carry out preclinical toxicity and bio-distribution studies required for regulatory approval of a clinical trial application for Phase I clinical studies of ONCOS-102 (Ad5/3-D24-GM-CSF) for therapy of advanced cancers (NCT01598129). The study design, route of administration and dosage differs from the clinical protocol and in more detail, investigate bio-distribution and toxicological profile of ONCOS-102 treatment in animal model. The study was carried out in 300 hamsters divided into nine test groups-three bio-distribution groups and six groups for analysis of toxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28796485/anti-fouling-cellulose-hybrid-bio-membrane-for-effective-oil-water-separation
#2
Ravichandran Honnavally Kollarigowda, Sinoj Abraham, Carlo Montemagno
Oil/water separation has been of great interest worldwide due to the increasingly serious environmental pollution caused by the abundant discharge of industrial wastewater, oil spill accidents and odors. Here, we describe simple and economical super-hydrophobic hybrid membranes for effective oil/water separation. Eco-friendly, anti-fouling membranes were fabricated for oil/water separation, waste particle filtration, the blocking of thiol-based odor materials, etc., by using cellulose membrane filter (CM). CM was modified from their original super hydrophilic nature into a super-hydrophobic surface via a reversible addition-fragmentation chain transfer (RAFT) technique...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28780961/natural-and-bioinspired-nanostructured-bactericidal-surfaces
#3
REVIEW
Abinash Tripathy, Prosenjit Sen, Bo Su, Wuge H Briscoe
Bacterial antibiotic resistance is becoming more widespread due to excessive use of antibiotics in healthcare and agriculture. At the same time the development of new antibiotics has effectively ground to a hold. Chemical modifications of material surfaces have poor long-term performance in preventing bacterial build-up and hence approaches for realising bactericidal action through physical surface topography have become increasingly important in recent years. The complex nature of the bacteria cell wall interactions with nanostructured surfaces represents many challenges while the design of nanostructured bactericidal surfaces is considered...
July 27, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28770933/exploring-catalyst-passivation-with-nmr-relaxation
#4
Neil Robinson, Lynn F Gladden, Carmine D'Agostino
NMR relaxation has recently emerged as a novel and non-invasive tool for probing the surface dynamics of adsorbate molecules within liquid-saturated mesoporous catalysts. The elucidation of such dynamics is of particular relevance to the study and development of solvated green catalytic processes, such as the production of chemicals and fuels from bio-resources. In this paper we develop and implement a protocol using high field (1)H NMR spin-lattice relaxation as a probe of the reorientational dynamics of liquids imbibed within mesoporous oxide materials...
August 3, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28759793/modelling-recovery-of-ammonium-from-urine-by-electro-concentration-in-a-3-chamber-cell
#5
Emma Thompson Brewster, Johannes Jermakka, Stefano Freguia, Damien J Batstone
Electro-concentration enables treatment and nutrient recovery from source-separated urine, and is a potential technology for on-site treatment using a 3 compartment configuration that has anode, cathode and middle concentrate compartments. There is a particular focus on driving concentration towards the precipitation threshold in the concentrate compartment to generate solid ammonium salts, including ammonium bicarbonate. To evaluate controlling mechanisms and the feasibility of achieving high concentrations, a dynamic mechanistic model was developed and validated using experiments with synthetic urine...
July 20, 2017: Water Research
https://www.readbyqxmd.com/read/28753735/isovalent-agiii-agiii-agii-agii-mixed-valent-agii-agiii-and-corrolato-based-mixed-valency-in-%C3%AF-%C3%AF-%C3%AF-%C3%AF-linked-bis-corrolato-silver-n-complexes
#6
Bratati Patra, Sebastian Sobottka, Woormileela Sinha, Biprajit Sarkar, Sanjib Kar
Mixed-valent compounds are fascinating entities that are useful as models for investigating electron transfer reactions, and find use in a host of biologically relevant redox processes. While the bio-relevant metal copper is well established in mixed-valent chemistry, the AgII/AgIII mixed-valent combination of its higher congener in a molecular complex has rarely been reported before. We present here the synthesis of a new linked bis{corrolato-silver(III)} complex and its characterization in five different redox states...
July 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28746829/imaging-chemistry-inside-living-cells-by-stimulated-raman-scattering-microscopy
#7
REVIEW
Hyeon Jeong Lee, Ji-Xin Cheng
Stimulated Raman scattering (SRS) microscopy is a vibrational imaging platform developed to visualize chemical content of a biological sample based on molecular vibrational fingerprints. With high-speed, high-sensitivity, and three-dimensional sectioning capability, SRS microscopy has been used to study chemical distribution, molecular transport, and metabolic conversion in living cells in a label-free manner. Moreover, aided with bio-orthogonal small-volume Raman probes, SRS microscopy allows direct imaging of metabolic activities of small molecules in living cells...
July 23, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28743564/evolving-biocatalysis-to-meet-bioeconomy-challenges-and-opportunities
#8
REVIEW
Alessandro Pellis, Sara Cantone, Cynthia Ebert, Lucia Gardossi
The unique selectivity of enzymes, along with their remarkable catalytic activity, constitute powerful tools for transforming renewable feedstock and also for adding value to an array of building blocks and monomers produced by the emerging bio-based chemistry sector. Although some relevant biotransformations run at the ton scale demonstrate the success of biocatalysis in industry, there is still a huge untapped potential of catalytic activities available for targeted valorization of new raw materials, such as waste streams and CO2...
July 22, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28730213/magnetic-separation-its-application-in-mining-waste-purification-medicine-biochemistry-and-chemistry
#9
REVIEW
M Iranmanesh, J Hulliger
The use of strong magnetic field gradients and high magnetic fields generated by permanent magnets or superconducting coils has found applications in many fields such as mining, solid state chemistry, biochemistry and medical research. Lab scale or industrial implementations involve separation of macro- and nanoparticles, cells, proteins, and macromolecules down to small molecules and ions. Most promising are those attempts where the object to be separated is attached to a strong magnetic nanoparticle. Here, all kinds of specific affinity interactions are used to attach magnetic carrier particles to mainly objects of biological interest...
July 21, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28727448/extensive-survey-of-antibody-invariant-positions-for-efficient-chemical-conjugation-using-expanded-genetic-codes
#10
Akifumi Kato, Mitsuo Kuratani, Tatsuo Yanagisawa, Kazumasa Ohtake, Akiko Hayashi, Yoshimi Amano, Kaname Kimura, Shigeyuki Yokoyama, Kensaku Sakamoto, Yasuhisa Shiraishi
The site-specific chemical conjugation of proteins, following synthesis with an expanded genetic code, promises to advance antibody-based technologies, including antibody drug conjugation and the creation of bispecific Fab dimers. The incorporation of non-natural amino acids into antibodies not only guarantees site specificity but also allows the use of bio-orthogonal chemistry. However, the efficiency of amino acid incorporation fluctuates significantly among different sites, thereby hampering the identification of useful conjugation sites...
August 16, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28722059/nanofluidics-in-two-dimensional-layered-materials-inspirations-from-nature
#11
REVIEW
Jun Gao, Yaping Feng, Wei Guo, Lei Jiang
With the advance of chemistry, materials science, and nanotechnology, significant progress has been achieved in the design and application of synthetic nanofluidic devices and materials, mimicking the gating, rectifying, and adaptive functions of biological ion channels. Fundamental physics and chemistry behind these novel transport phenomena on the nanoscale have been explored in depth on single-pore platforms. However, toward real-world applications, one major challenge is to extrapolate these single-pore devices into macroscopic materials...
July 19, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28702661/clinically-approved-pegylated-nanoparticles-are-covered-by-a-protein-corona-that-boosts-the-uptake-by-cancer-cells
#12
M Papi, D Caputo, V Palmieri, R Coppola, S Palchetti, F Bugli, C Martini, L Digiacomo, D Pozzi, G Caracciolo
Today, liposomes are an advanced technology of drug carriers with a dozen drugs in clinical practice and many more in clinical trials. A bottleneck associated with the clinical translation of liposomes has long been 'opsonization', i.e. the adsorption of plasma proteins at the liposome surface resulting in their rapid clearance from circulation. For decades, the most popular way to avoid opsonization has been grafting polyethylene glycol (PEG) onto the liposome surface. Recent studies have clarified that grafting PEG onto the liposome surface reduces, but does not completely prevent protein binding...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28701044/-new-physical-chemistry-insight-in-experimental-bio-physical-chemistry
#13
Kankan Bhattacharyya, Gang-Yu Liu, Martin T Zanni
No abstract text is available yet for this article.
July 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28698739/complete-genome-sequence-of-actinomadura-parvosata-subsp-kistnae-a-rich-source-of-novel-natural-product-bio-chemistry
#14
Kalina Kusserow, Tobias A M Gulder
The soil dwelling actinomycete strain Actinomadura parvosata subsp. kistnae is the producer of the antiviral antibiotics kistamicin A and B. Genome sequencing and bioinformatic analysis revealed the presence of the kistamycin biosynthetic gene cluster responsible for the formation of these non-ribosomal peptides as well as an impressive number of yet uncharacterized biosynthetic pathways. This includes polyketide, ribosomal and non-ribosomal peptide and a large number of terpenoid biosynthetic loci encoding yet unknown natural products...
2017: Journal of Genomics
https://www.readbyqxmd.com/read/28696096/potassium-and-zeolitic-structure-modified-ultra-microporous-adsorbent-materials-from-a-renewable-feedstock-with-favourable-surface-chemistry-for-co2-capture
#15
Xin Liu, Yuan Sun, Jingjing Liu, Cheng-Gong Sun, Hao Liu, Qian Xue, Emily F Smith, Colin E Snape
Novel hierarchically structured microporous bio-carbons with exceptionally high capacities for CO2 capture have been synthesized from the abundant agricultural waste of rice husk (RH), using a facile methodology that effectively integrated carbonisation, activation and potassium intercalation into a one-step process. Textural characterisation demonstrates that the synthesized bio-carbons exhibit exceedingly high ultra-microporosity accounting for up to 95% of total porosity mainly as a result of the naturally occurring silicon compounds within the RH molecular framework structures...
July 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28694021/recombinant-and-chemo-bio-orthogonal-synthesis-of-liposomal-thrombomodulin-and-its-antithrombotic-activity
#16
Lin Wang, Rui Jiang, Yang Liu, Maosheng Cheng, Qingyu Wu, Xue-Long Sun
Thrombomodulin (TM) is an endothelial cell membrane protein that acts as a major cofactor in the protein C anticoagulant pathway. The EGF-like domains 4-6 of TM (TM456) are essential for PC activation. In this study, we proposed a liposomal recombinant TM conjugate to mimic the membrane TM structure and its anticoagulant activity. First, a DSPE-PEG2000-TM456 was successfully synthesized by site-specific conjugation of azido-TM456 with DSPE-PEG2000-DBCO via copper-free click chemistry quantitatively. Then, liposome-TM456 was fabricated via direct liposome formation with the DSPE-PEG2000-TM456 and other lipids...
July 7, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28691693/influence-of-physico-mechanical-properties-of-elastomeric-material-for-different-cell-growth
#17
Jyoti Wala, Debashis Maji, Soumen Das
The tunable mechanical and physical properties of Polydimethylsiloxane (PDMS) are commonly utilized for studying cellular dynamics. However, the inherent hydrophobic nature of PDMS limits its application as cell culture films. Various surface modification techniques render PDMS films hydrophilic which alters the surface chemistry, elasticity, roughness and cell attachment of anchorage dependent cell types to the films. The surface properties of thin film lead to alteration in bio-mechano-physical properties of cells and therefore could be used as mechanical signature for viability testing of different normal and cancerous cells...
July 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28686409/structural-characterization-of-bio-functionalized-gold-nanoparticles-by-ultrahigh-resolution-mass-spectrometry
#18
Simone Nicolardi, Yuri E M van der Burgt, Jeroen D C Codée, Manfred Wuhrer, Cornelis H Hokke, Fabrizio Chiodo
Bio-functionalized gold nanoparticles (AuNPs) enable innovative translational research and development in biomedicine. Biomolecules such as peptides, proteins, lipids and carbohydrates can be assembled onto AuNPs to yield nanomaterials with unique properties for applications in imaging, photothermal therapy, vaccination strategies and drug delivery. The characterization of functionalized AuNPs still remains an analytical challenge that normally requires the combination of multiple techniques. Laser desorption/ionization (LDI) and matrix-assisted LDI (MALDI) has been applied successfully in combination with time-of-flight (TOF) mass spectrometry (MS) for the analysis of surface chemistry of AuNPs functionalized with synthetic ligands, however only for ligands with a molecular mass limited to 1000 Da...
July 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28685962/flow-asymmetric-propargylation-development-of-continuous-processes-for-the-preparation-of-a-chiral-%C3%AE-amino-alcohol
#19
Hui Li, Jillian W Sheeran, Andrew M Clausen, Yuan-Qing Fang, Matthew M Bio, Scott Bader
The development of a flow chemistry process for asymmetric propargylation using allene gas as a reagent is reported. The connected continuous process of allene dissolution, lithiation, Li-Zn transmetallation, and asymmetric propargylation provides homopropargyl β-amino alcohol 1 with high regio- and diastereoselectivity in high yield. This flow process enables practical use of an unstable allenyllithium intermediate. The process uses the commercially available and recyclable (1S,2R)-N-pyrrolidinyl norephedrine as a ligand to promote the highly diastereoselective (32:1) propargylation...
August 1, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28685683/applications-of-cellulose-based-materials-in-sustained-drug-delivery-systems
#20
Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi, Yonghao Ni
Bio-compatible, bio-degradable, and bio-available excipients are of critical interest for drug delivery systems. Cellulose and its derivative-based excipients have been well studied due to their green/ natural and unique encapsulation/ binding properties. They are often used in controlled/ sustained drug delivery systems. In these applications, cellulose and its derivatives function generally can modify the solubility/gelling behavior of drugs, resulting in different mechanisms for controlling the release profiles of drugs...
July 5, 2017: Current Medicinal Chemistry
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