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https://www.readbyqxmd.com/read/28345352/metal-free-photoinduced-electron-transfer-atom-transfer-radical-polymerization-integrated-with-bio-inspired-polydopamine-chemistry-as-a-green-strategy-for-surface-engineering-of-magnetic-nanoparticles
#1
Yang Yang, Xuegang Liu, Gang Ye, Shan Zhu, Zhe Wang, Xiaomei Huo, Krzysztof Matyjaszewski, Yuexiang Lu, Jing Chen
Developing green and efficient technologies for surface modification of magnetic nanoparticles (MNPs) is of crucial importance for their biomedical and environmental applications. This study reports, for the first time, a novel strategy by integrating metal-free photoinduced electron transfer-atom transfer radical polymerization (PET-ATRP) with the bio-inspired polydopamine (PDA) chemistry for controlled architecture of functional polymer brushes from MNPs. Conformal PDA encapsulation layers were initially generated on the surfaces of MNPs, which served as the protective shells while providing an ideal platform for tethering 2-bromo-2-phenylacetic acid (BPA), a highly efficient initiator...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28336902/magnetic-hybrid-nanosorbents-for-the-uptake-of-paraquat-from-water
#2
Tiago Fernandes, Sofia F Soares, Tito Trindade, Ana L Daniel-da-Silva
Although paraquat has been banned in European countries, this herbicide is still used all over the world, thanks to its low-cost, high-efficiency, and fast action. Because paraquat is highly toxic to humans and animals, there is interest in mitigating the consequences of its use, namely by implementing removal procedures capable of curbing its environmental and health risks. This research describes new magnetic nanosorbents composed of magnetite cores functionalized with bio-hybrid siliceous shells, that can be used to uptake paraquat from water using magnetically-assisted procedures...
March 18, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28332847/phase-behavior-and-physical-properties-of-new-biobased-ionic-liquid-crystals
#3
Ariel Antonio Campos Toledo Hijo, Guilherme José Maximo, Mariana Conceição Costa, Rosiane Lopes Cunha, Jorge Fernando Brandão Pereira, Kiki Adi Kurnia, Eduardo A Caldas Batista, Antonio J A Meirelles
Protic ionic liquids (PILs) have emerged as promising compounds and attracted the interest of the industry and the academy community, due to their easy preparation and unique properties. In the context of green chemistry, the use of biocompounds, such as fatty acids for their synthesis could disclose a possible alternative way to produce ILs with low or non-toxic effect and consequently, expanding their applicability in bio-based processes or in the development of bioproducts. This work addressed efforts to a better comprehension of the complex Solid-Liquid-Crystal-Liquid thermodynamic equilibrium of twenty new PILs synthesized by using fatty acids commonly found in vegetable oils, as well as their rheological profile and self-assembling ability...
March 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28319669/cell-adhesion-on-dynamic-supramolecular-surfaces-probed-by-fluid-force-microscopy-based-single-cell-force-spectroscopy
#4
Shrikrishnan Sankaran, Leena Jaatinen, Jenny Brinkmann, Tomaso Zambelli, Janos Vörös, Pascal Jonkheijm
Biomimetic and stimuli-responsive cell-material interfaces are actively being developed to study and control various cell-dynamics phenomena. Since cells naturally reside in the highly dynamic and complex environment of the extracellular matrix, attempts are being made to replicate these conditions in synthetic biomaterials. Supramolecular chemistry, dealing with noncovalent interactions, has recently provided possibilities to incorporate such dynamicity and responsiveness in various types of architectures...
March 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28301944/orientation-and-characterization-of-immobilized-antibodies-for-improved-immunoassays-review
#5
Nicholas G Welch, Judith A Scoble, Benjamin W Muir, Paul J Pigram
Orientation of surface immobilized capture proteins, such as antibodies, plays a critical role in the performance of immunoassays. The sensitivity of immunodiagnostic procedures is dependent on presentation of the antibody, with optimum performance requiring the antigen binding sites be directed toward the solution phase. This review describes the most recent methods for oriented antibody immobilization and the characterization techniques employed for investigation of the antibody state. The introduction describes the importance of oriented antibodies for maximizing biosensor capabilities...
March 16, 2017: Biointerphases
https://www.readbyqxmd.com/read/28301814/engineered-nano-particles-nature-behavior-and-effect-on-the-environment
#6
REVIEW
Linee Goswami, Ki-Hyun Kim, Akash Deep, Pallabi Das, Satya Sundar Bhattacharya, Sandeep Kumar, Adedeji A Adelodun
Increased application of engineered nano particles (ENPs) in production of various appliances and consumer items is increasing their presence in the natural environment. Although a wide variety of nano particles (NPs) are ubiquitously dispersed in ecosystems, risk assessment guidelines to describe their ageing, direct exposure, and long-term accumulation characteristics are poorly developed. In this review, we describe what is known about the life cycle of ENPs and their impact on natural systems and examine if there is a cohesive relationship between their transformation processes and bio-accessibility in various food chains...
March 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28299694/electrochemical-quartz-crystal-nanobalance-eqcn-based-biosensor-for-sensitive-detection-of-antibiotic-residues-in-milk
#7
Sunil Bhand, Geetesh K Mishra
An electrochemical quartz crystal nanobalance (EQCN), which provides real-time analysis of dynamic surface events, is a valuable tool for analyzing biomolecular interactions. EQCN biosensors are based on mass-sensitive measurements that can detect small mass changes caused by chemical binding to small piezoelectric crystals. Among the various biosensors, the piezoelectric biosensor is considered one of the most sensitive analytical techniques, capable of detecting antigens at picogram levels. EQCN is an effective monitoring technique for regulation of the antibiotics below the maximum residual limit (MRL)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28295960/interactions-of-renal-clearable-gold-nanoparticles-with-tumor-microenvironments-vasculature-and-acidity-effects
#8
Mengxiao Yu, Chen Zhou, Li Liu, Shanrong Zhang, Shasha Sun, Julia D Hankins, Xiankai Sun, Jie Zheng
The success of nanomedicines in the clinic depends on our comprehensive understanding of nano-bio interactions in tumor microenvironments, which are characterized by dense leaky microvasculature and acidic extracellular pH (pHe ) values. Herein, we investigated the accumulation of ultrasmall renal-clearable gold NPs (AuNPs) with and without acidity targeting in xenograft mouse models of two prostate cancer types, PC-3 and LNCaP, with distinct microenvironments. Our results show that both sets of AuNPs could easily penetrate into the tumors but their uptake and retention were mainly dictated by the tumor microvasculature and the enhanced permeability and retention effect over the entire targeting process...
March 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28290568/monomer-design-strategies-to-create-natural-product-based-polymer-materials
#9
REVIEW
Samantha L Kristufek, Kevin T Wacker, Yi-Yun Timothy Tsao, Lu Su, Karen L Wooley
Covering: 2010-Aug. 2016In an effort towards enhancing function and sustainability, natural products have become of interest in the field of polymer chemistry. This review details the blending of chemistries developed through synthetic organic chemistry and polymer chemistry. Through synthetic organic chemical transformations, such as functional group interconversion, a protection/deprotection series, or installation of a functional group, various designs towards novel, synthetic, bio-based polymer systems are described...
March 14, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28287138/biofunctionalized-3-d-carbon-nano-network-platform-for-enhanced-fibroblast-cell-adhesion
#10
A K M Rezaul Haque Chowdhury, Amirhossein Tavangar, Bo Tan, Krishnan Venkatakrishnan
Carbon nanomaterials have been investigated for various biomedical applications. In most cases, however, these nanomaterials must be functionalized biologically or chemically due to their biological inertness or possible cytotoxicity. Here, we report the development of a new carbon nanomaterial with a bioactive phase that significantly promotes cell adhesion. We synthesize the bioactive phase by introducing self-assembled nanotopography and altered nano-chemistry to graphite substrates using ultrafast laser...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28266786/exploring-protein-nanoparticle-interactions-with-coarse-grained-protein-folding-models
#11
Shuai Wei, Logan S Ahlstrom, Charles L Brooks
Understanding the fundamental biophysics behind protein-nanoparticle (NP) interactions is essential for the design and engineering bio-NP systems. The authors describe the development of a coarse-grained protein-NP model that utilizes a structure centric protein model. A key feature of the protein-NP model is the quantitative inclusion of the hydrophobic character of residues in the protein and their interactions with the NP surface. In addition, the curvature of the NP is taken into account, capturing the protein behavior on NPs of different size...
March 7, 2017: Small
https://www.readbyqxmd.com/read/28252973/dna-with-ionic-atomic-and-clustered-silver-an-xps-study
#12
Ivan L Volkov, Anastasiya Smirnova, Anna A Makarova, Zakhar V Reveguk, Ruslan R Ramazanov, Dmitry Yu Usachov, Vera K Adamchuk, Alexei I Kononov
The rapidly developing field of bionanotechnology requires detailed knowledge of the mechanisms of interaction between inorganic matter and biomolecules. Under conditions different from those in an aqueous solution, however, the chemistry of these systems is elusive and may differ dramatically from their interactions in vitro and in vivo. Here, we report for the first time a photoemission study of a metal silver-DNA interface, formed in vacuo, in comparison with DNA-Ag(+) and fluorescent DNA-Ag complexes formed in solution...
March 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28248430/reconstitution-of-vanadium-haloperoxidase-s-catalytic-activity-by-boric-acid-towards-a-potential-biocatalytic-role-of-boron
#13
Filipe Natalio, Stefanie Wiese, Wolfgang Brandt, Ludger Wessjohann
Boron's unusual properties inspired major advances in chemistry. In Nature, the existence and importance of boron has been fairly explored (e.g. bacterial signaling, plant development) but its role as biological catalyst was never reported. Here, we show that boric acid [B(OH)3] can restore chloroperoxidase activity of Curvularia inaequalis recombinant apo-haloperoxidase's (HPO) in the presence of hydrogen peroxide and chloride ions. Molecular modeling and semi-empirical PM7 calculations support a thermodynamically highly favored (bio)catalytic mechanism similarly to vanadium haloperoxidases (V-HPO) in which [B(OH)3] is assumedly located in apo-HPO's active site and a monoperoxyborate [B(OH)3(OOH)-] intermediate is formed and stabilized by interaction with specific active site amino acids leading ultimately to the formation of HOCl...
March 1, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28242376/cell-based-therapeutics-in-type-1-diabetes-mellitus
#14
Fernanda Zamboni, Maurice N Collins
This review focuses on Type 1 diabetes mellitus (T1DM) and the role of bioengineering, nanotechnology and cell therapy in its treatment. T1DM is discussed in terms of its prevalence as well as the role of the extra cellular matrix (ECM) of the pancreas in its development and mode of action. Surface engineering strategies and the chemistries behind important cell encapsulation techniques, which are emerging from recent research in immunosuppression, are described. Key enabling technologies such as therapeutic agent immobilization on cells, oxygen releasing systems, gene delivery and bio imaging are assessed with respect to T1DM...
February 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28240554/enzyme-catalyzed-intramolecular-enantioselective-hydroalkoxylation
#15
Shu-Shan Gao, Marc Garcia-Borràs, Joyann S Barber, Yang Hai, Abing Duan, Neil K Garg, K N Houk, Yi Tang
Hydroalkoxylation is a powerful and efficient method of forming C-O bonds and cyclic ethers in synthetic chemistry. In studying the biosynthesis of the fungal natural product herqueinone, we identified an enzyme that can perform an intramolecular enantioselective hydroalkoxylation reaction. PhnH catalyzes the addition of a phenol to the terminal olefin of a reverse prenyl group to give a dihydrobenzofuran product. The enzyme accelerates the reaction by 3 × 10(5)-fold compared to the uncatalyzed reaction. PhnH belongs to a superfamily of proteins with a domain of unknown function (DUF3237), of which no member has a previously verified function...
March 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28238127/ligand-exchange-and-1-h-nmr-quantification-of-single-and-mixed-moiety-thiolated-ligand-shells-on-gold-nanoparticles
#16
Ashley M Smith, Jill E Millstone
The use of nanoparticles in biomedicine critically depends on their surface chemistry. For metal nanoparticles, a common way to tune this surface chemistry is through mass action ligand exchange, where ligand exchange can be used to expand the functionality of the resulting nanoparticle conjugates. Specifically, the quantity, identity, and arrangement of the molecules in the resulting ligand shell each can be tuned significantly. Here, we describe methods to exchange and quantify thiolated and non-thiolated ligands on gold nanoparticle surfaces...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28237511/coupling-genetic-code-expansion-and-metabolic-engineering-for-synthetic-cells
#17
REVIEW
Jan-Stefan Völler, Nediljko Budisa
Orthogonal protein translation with noncanonical amino acids (ncAAs) has become a standard method in biosciences. Whereas much effort is made to broaden the chemical space of ncAAs, only few attempts on their systematic low-cost in situ production are reported until now. The main aim is to engineer cells with newly designed biosynthetic pathways coupled with orthogonal aminoacyl-tRNA synthetase/tRNA pairs (o-pairs). These should provide cost-effective solutions to industrially relevant bio-production problems, such as peptide/protein production beyond the canonical set of natural molecules and to expand the arsenal of chemistries available for living cells...
February 23, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28225616/a-straightforward-approach-for-3d-bacterial-printing
#18
Benjamin A E Lehner, Dominik T Schmieden, Anne S Meyer
Sustainable and personally tailored materials production is an emerging challenge to society. Living organisms can produce and pattern an extraordinarily wide range of different molecules in a sustainable way. These natural systems offer an abundant source of inspiration for the development of new environmentally friendly materials production techniques. In this paper, we describe the first steps toward the 3-dimensional printing of bacterial cultures for materials production and patterning. This methodology combines the capability of bacteria to form new materials with the reproducibility and tailored approach of 3D printing systems...
March 1, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28222260/k-channel-a-multifunctional-architecture-for-dynamically-reconfigurable-sample-processing-in-droplet-microfluidics
#19
Steven R Doonan, Ryan C Bailey
By rapidly creating libraries of thousands of unique, miniaturized reactors, droplet microfluidics provides a powerful method for automating high-throughput chemical analysis. In order to engineer in-droplet assays, microfluidic devices must add reagents into droplets, remove fluid from droplets, and perform other necessary operations, each typically provided by a unique, specialized geometry. Unfortunately, modifying device performance or changing operations usually requires re-engineering the device among these specialized geometries, a time-consuming and costly process when optimizing in-droplet assays...
March 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28206741/polyketide-bioderivatization-using-the-promiscuous-acyltransferase-kircii
#20
Ewa M Musiol-Kroll, Florian Zubeil, Thomas Schafhauser, Thomas Härtner, Andreas Kulik, John McArthur, Irina Koryakina, Wolfgang Wohlleben, Stephanie Grond, Gavin J Williams, Sang Yup Lee, Tilmann Weber
During polyketide biosynthesis, acyltransferases (ATs) are the essential gatekeepers which provide the assembly lines with precursors and thus contribute greatly to structural diversity. Previously, we demonstrated that the discrete AT KirCII from the kirromycin antibiotic pathway accesses nonmalonate extender units. Here, we exploit the promiscuity of KirCII to generate new kirromycins with allyl- and propargyl-side chains in vivo, the latter were utilized as educts for further modification by "click" chemistry...
February 22, 2017: ACS Synthetic Biology
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