Read by QxMD icon Read

bio chemistry

Xiuwen Chen, He Zhao, Chunlian Chen, Huanfeng Jiang, Min Zhang
By a hydrogen transfer-mediated activation mode for non-activated pyridyl nucleus, a general catalytic hydrogen transfer-mediated -functionalization of 1,8-naphthyridines is reported for the first time. Its -site selectively couples with the C8-site of various tetrahydroquinolines (THQs) to afford novel -functionalized tetrahydro 1,8-naphthyridines, a class of synthetically useful building blocks and potential candidates for the discovery of therapeutic and bio-active products. The utilization of THQs as inactive hydrogen donors (HDs) appears to be a key strategy to overcome the over-hydrogenation barrier and address the chemo-selectivity issue...
September 19, 2017: Angewandte Chemie
Chintan Bhagat, Pravin Dudhagara, Shantilal Tank
Growing industrialisation and desire for better economy of countries accelerated the emission of greenhouse gasses, more than the buffering capacity of earth atmosphere. Among, various Green House Gasses (GHGs), CO2 occupies the first position in anthroposphere and has detrimental effects on the ecosystem. For decarbonization, several non-biological methods of carbon capture, utilisation, and storage (CCUS) are in use from last few decades, but they are suffering from narrow applicability. Recently, CO2 emission and its disposal related problem encourage for implementation of bioprocessing to achieve zero waste economy for a sustainable environment...
September 18, 2017: Journal of Applied Microbiology
Rémi Ducasse, Wei-An Wang, Marina Garcia-Jove Navarro, Nicolas Debons, Alexandra Colin, Jérémie Gautier, Jean-Michel Guigner, François Guyot, Zoher Gueroui
Artificial bio-based scaffolds offer broad applications in bioinspired chemistry, nanomedicine, and material science. One current challenge is to understand how the programmed self-assembly of biomolecules at the nanometre level can dictate the emergence of new functional properties at the mesoscopic scale. Here we report a general approach to design genetically encoded protein-based scaffolds with modular biochemical and magnetic functions. By combining chemically induced dimerization strategies and biomineralisation, we engineered ferritin nanocages to nucleate and manipulate microtubule structures upon magnetic actuation...
September 12, 2017: Scientific Reports
Jianfeng Guo, Kamil Rahme, Yan He, Lin-Lin Li, Justin D Holmes, Caitriona M O'Driscoll
Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses...
2017: International Journal of Nanomedicine
David A Simpson, Robert G Ryan, Liam T Hall, Evgeniy Panchenko, Simon C Drew, Steven Petrou, Paul S Donnelly, Paul Mulvaney, Lloyd C L Hollenberg
Magnetic resonance spectroscopy is one of the most important tools in chemical and bio-medical research. However, sensitivity limitations typically restrict imaging resolution to ~ 10 µm. Here we bring quantum control to the detection of chemical systems to demonstrate high-resolution electron spin imaging using the quantum properties of an array of nitrogen-vacancy centres in diamond. Our electron paramagnetic resonance microscope selectively images electronic spin species by precisely tuning a magnetic field to bring the quantum probes into resonance with the external target spins...
September 6, 2017: Nature Communications
Jisoo Shin, Eun Jung Choi, Jung Ho Cho, Ann-Na Cho, Yoonhee Jin, Kisuk Yang, Changsik Song, Seung-Woo Cho
Electrically conductive hyaluronic acid (HA) hydrogels incorporated with single-walled carbon nanotubes (CNTs) and/or polypyrrole (PPy) were developed to promote differentiation of human neural stem/progenitor cells (hNSPCs). The CNT and PPy nanocomposites, which do not easily disperse in aqueous phases, dispersed well and were efficiently incorporated into catechol-functionalized HA (HA-CA) hydrogels by the oxidative catechol chemistry used for hydrogel crosslinking. The prepared electroconductive HA hydrogels provided dynamic, electrically conductive three-dimensional (3D) extracellular matrix environments that were biocompatible with hNSPCs...
September 6, 2017: Biomacromolecules
Edinson Yara-Varón, Ying Li, Mercè Balcells, Ramon Canela-Garayoa, Anne-Sylvie Fabiano-Tixier, Farid Chemat
Since solvents of petroleum origin are now strictly regulated worldwide, there is a growing demand for using greener, bio-based and renewable solvents for extraction, purification and formulation of natural and food products. The ideal alternative solvents are non-volatile organic compounds (VOCs) that have high dissolving power and flash point, together with low toxicity and less environmental impact. They should be obtained from renewable resources at a reasonable price and be easy to recycle. Based on the principles of Green Chemistry and Green Engineering, vegetable oils could become an ideal alternative solvent to extract compounds for purification, enrichment, or even pollution remediation...
September 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xinxin Zhou, Baochun Guo, Liqun Zhang, Guo-Hua Hu
Mimicking natural structures has been highly pursued in the fabrication of synthetic polymeric materials due to its potential in breaking the bottlenecks in mechanical properties and extending the applications of polymeric materials. Recently, it has been revealed that the energy dissipating mechanisms via sacrificial bonds are among the important factors which account for strong and tough attributes of natural materials. Great progress in synthesis of polymeric materials consisting of sacrificial bonds has been achieved...
September 4, 2017: Chemical Society Reviews
Zhong Wang, Shujun Zhao, Ruyuan Song, Wei Zhang, Shifeng Zhang, Jianzhang Li
Novel soybean meal-based biomimetic (STP) adhesives were fabricated via soybean meal (SM) and enhanced by tannic acid (TA) and polyetheylenimine (PEI) (TAPI) co-crosslinking network based on natural polyphenol-inspired chemistry. The multiple physico-chemical interactions (including intermolecular H-bonding and covalent bonding) between the TAPI co-crosslinking system and SM matrices were examined by the Fourier transform infrared spectroscopy, solid-state (13)C nuclear magnetic resonance, X-ray diffraction, thermogravimetric analysis, and scanning electron microscopy...
August 29, 2017: Scientific Reports
Christoph Edlinger, Tomaz Einfalt, Mariana Spulber, Anja Car, Wolfgang Meier, Cornelia G Palivan
We describe an innovative strategy to generate catalytic compartments with triggered functionality at the nanoscale level by combining pH-reversible biovalves and enzyme-loaded synthetic compartments. The biovalve has been engineered by the attachment of stimuli-responsive peptides to a genetically modified channel porin, enabling a reversible change of the molecular flow through the pores of the porin in response to a pH change in the local environment. The biovalve functionality triggers the reaction inside the cavity of the enzyme-loaded compartments by switching the in situ activity of the enzymes on/off based on a reversible change of the permeability of the membrane, which blocks or allows the passage of substrates and products...
September 13, 2017: Nano Letters
Matin Mahmoudifard, Masoud Soleimani, Manuchehr Vossoughi
The surface of polyacrylonitrile electrospun nanofibrous membrane (PAN NFM) was aminated by the ammonia plasma treatment. The content of amine groups has been estimated for different time of plasma treatment. The newly generated amine groups were successfully activated by glutaraldehyde (Ga) for the covalent attachment of the protein molecules on the NFM surface. Bio-functionalization of ammonia plasma treated PAN NFM was carried out by the primary antibodies (Ab) immobilization as a protein model through Ga coupling chemistry...
August 25, 2017: Scientific Reports
Evdokia Syranidou, Katerina Karkanorachaki, Filippo Amorotti, Eftychia Repouskou, Kevin Kroll, Boris Kolvenbach, Philippe F-X Corvini, Fabio Fava, Nicolas Kalogerakis
This study investigated the potential of bacterial-mediated polyethylene (PE) degradation in a two-phase microcosm experiment. During phase I, naturally weathered PE films were incubated for 6 months with the indigenous marine community alone as well as bioaugmented with strains able to grow in minimal medium with linear low-density polyethylene (LLDPE) as the sole carbon source. At the end of phase I the developed biofilm was harvested and re-inoculated with naturally weathered PE films. Bacteria from both treatments were able to establish an active population on the PE surfaces as the biofilm community developed in a time dependent way...
2017: PloS One
Lynne E Macaskie, Iryna P Mikheenko, Jacob B Omajai, Alan J Stephen, Joseph Wood
Microbially generated or supported nanocatalysts have potential applications in green chemistry and environmental application. However, precious (and base) metals biorefined from wastes may be useful for making cheap, low-grade catalysts for clean energy production. The concept of bionanomaterials for energy applications is reviewed with respect to potential fuel cell applications, bio-catalytic upgrading of oils and manufacturing 'drop-in fuel' precursors. Cheap, effective biomaterials would facilitate progress towards dual development goals of sustainable consumption and production patterns and help to ensure access to affordable, reliable, sustainable and modern energy...
August 22, 2017: Microbial Biotechnology
Pavlo Ivanchenko, José Manuel Delgado-López, Michele Iafisco, Jaime Gómez-Morales, Anna Tampieri, Gianmario Martra, Yuriy Sakhno
The surface structure and hydrophilicity of synthetic nanocrystalline apatite with strongly bound citrates on their surface are here investigated at the molecular level, by combining advanced IR spectroscopy, microgravimetry and adsorption microcalorimetry. Citrate are found to form unidentate-like and ionic-like complexes with surface Ca(2+) ions, with a surface coverage closely resembling that present in bone apatite platelets (i.e., 1 molecule/(n nm)(2), with n ranging between 1.4 and 1.6). These surface complexes are part of a hydrated non-apatitic surface layer with a sub-nanometre thickness...
August 21, 2017: Scientific Reports
Lukasz Kuryk, Lotta Vassilev, Tuuli Ranki, Akseli Hemminki, Aila Karioja-Kallio, Onerva Levälampi, Antti Vuolanto, Vincenzo Cerullo, Sari Pesonen
The purpose of this work was to carry out preclinical toxicity and bio-distribution studies required for regulatory approval of a clinical trial application for Phase I clinical studies of ONCOS-102 (Ad5/3-D24-GM-CSF) for therapy of advanced cancers (NCT01598129). The study design, route of administration and dosage differs from the clinical protocol and in more detail, investigate bio-distribution and toxicological profile of ONCOS-102 treatment in animal model. The study was carried out in 300 hamsters divided into nine test groups-three bio-distribution groups and six groups for analysis of toxicity...
2017: PloS One
Ravichandran H Kollarigowda, Sinoj Abraham, Carlo D Montemagno
Oil/water separation has been of great interest worldwide because of the increasingly serious environmental pollution caused by the abundant discharge of industrial wastewater, oil spill accidents, and odors. Here, we describe simple and economical superhydrophobic hybrid membranes for effective oil/water separation. Eco-friendly, antifouling membranes were fabricated for oil/water separation, waste particle filtration, the blocking of thiol-based odor materials, etc., by using a cellulose membrane (CM) filter...
August 22, 2017: ACS Applied Materials & Interfaces
Abinash Tripathy, Prosenjit Sen, Bo Su, Wuge H Briscoe
Bacterial antibiotic resistance is becoming more widespread due to excessive use of antibiotics in healthcare and agriculture. At the same time the development of new antibiotics has effectively ground to a hold. Chemical modifications of material surfaces have poor long-term performance in preventing bacterial build-up and hence approaches for realising bactericidal action through physical surface topography have become increasingly important in recent years. The complex nature of the bacteria cell wall interactions with nanostructured surfaces represents many challenges while the design of nanostructured bactericidal surfaces is considered...
July 27, 2017: Advances in Colloid and Interface Science
Neil Robinson, Lynn F Gladden, Carmine D'Agostino
NMR relaxation has recently emerged as a novel and non-invasive tool for probing the surface dynamics of adsorbate molecules within liquid-saturated mesoporous catalysts. The elucidation of such dynamics is of particular relevance to the study and development of solvated green catalytic processes, such as the production of chemicals and fuels from bio-resources. In this paper we develop and implement a protocol using high field (1)H NMR spin-lattice relaxation as a probe of the reorientational dynamics of liquids imbibed within mesoporous oxide materials...
August 3, 2017: Faraday Discussions
Emma Thompson Brewster, Johannes Jermakka, Stefano Freguia, Damien J Batstone
Electro-concentration enables treatment and nutrient recovery from source-separated urine, and is a potential technology for on-site treatment using a 3 compartment configuration that has anode, cathode and middle concentrate compartments. There is a particular focus on driving concentration towards the precipitation threshold in the concentrate compartment to generate solid ammonium salts, including ammonium bicarbonate. To evaluate controlling mechanisms and the feasibility of achieving high concentrations, a dynamic mechanistic model was developed and validated using experiments with synthetic urine...
July 20, 2017: Water Research
Bratati Patra, Sebastian Sobottka, Woormileela Sinha, Biprajit Sarkar, Sanjib Kar
Mixed-valent compounds are fascinating entities that are useful as models for investigating electron-transfer reactions, and find use in a host of biologically relevant redox processes. Though the bio-relevant metal copper is well established in mixed-valent chemistry, the Ag(II) /Ag(III) mixed-valent combination of its higher congener in a molecular complex has rarely been reported before. This work reports the synthesis of a new β,β'-linked bis{corrolato-silver(III)} complex and its characterization in five different redox states...
July 28, 2017: Chemistry: a European Journal
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"