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Radiation Induced Heart Disease

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https://www.readbyqxmd.com/read/28440606/pathogenesis-and-prevention-of-radiation-induced-myocardial-fibrosis
#1
Li Kun Liu, Weiwei Ouyang, Xing Zhao, Sheng Fa Su, Yan Yang, Wen Jin Ding, Da Xian Luo, Zhi Xu He, Bing Lu
Radiation therapy is one of the most important methods for the treatment of malignant tumors. However, in radiotherapy for thoracic tumors such as breast cancer, lung cancer, esophageal cancer, and mediastinal lymphoma, the heart, located in the mediastinum, is inevitably affected by the irradiation, leading to pericardial disease, myocardial fibrosis, coronary artery disease, valvular lesions, and cardiac conduction system injury, which are considered radiation-induced heart diseases. Delayed cardiac injury especially myocardial fibrosis is more prominent, and its incidence is as high as 20–80%...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28424841/dosimetric-predictors-of-radiation-induced-pericardial-effusion-in%C3%A2-esophageal-cancer
#2
Ichiro Ogino, Shigenobu Watanabe, Kentaro Sakamaki, Yuka Ogino, Chikara Kunisaki, Kazuo Kimura
PURPOSE: To evaluate the dose-volume parameters of the pericardium and heart in order to reduce the risk of radiation-induced pericardial effusion (PE) and symptomatic PE (SPE) in esophageal cancer patients treated with concurrent chemoradiotherapy. METHODS: In 86 of 303 esophageal cancer patients, follow-up CT was obtained at least 24 months after concurrent chemoradiotherapy. Correlations between clinical factors, including risk factors for cardiac disease, dosimetric factors, and the incidence of PE and SPE after radiotherapy were analyzed using Cox proportional hazard regression analysis...
April 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28392465/l-carnitine-preserves-cardiac-function-by-activating-p38-mapk-nrf2-signalling-in-hearts-exposed-to-irradiation
#3
Zhigang Fan, Yang Han, Yuanpeng Ye, Chao Liu, Hui Cai
Radiation-induced heart damage (RIHD) is now considered to be one of the causes of mortality in cancer patients undergoing radiotherapy. Cardiac function impairments are clinical manifestations of RIHD. L-carnitine shows protective effects against irradiation and heart disease. This study was aimed to investigate the cardioprotective effects and potential molecular mechanisms of L-carnitine against RIHD. Mouse hearts were exposed to γ-radiation to induce RIHD. L-carnitine at doses of 100mg/Kg and 200mg/Kg was used to treat animals intraperitoneally...
June 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28342038/coronary-artery-calcium-in-breast-cancer-survivors-after-radiation-therapy
#4
Richard A P Takx, Rozemarijn Vliegenthart, U Joseph Schoepf, Lothar R Pilz, Stefan O Schoenberg, Pamela B Morris, Thomas Henzler, Paul Apfaltrer
The purpose of the current study is to investigate whether breast cancer survivors after radiation therapy have a higher burden of coronary artery calcium as a potential surrogate of radiation-induced accelerated coronary artery disease. 333 patients were included. 54 patients underwent chest CT ≥ 6 months after the start of radiation therapy (radiation therapy group), while 279 patients had a CT scan either prior to or without undergoing radiation therapy (RT). Coronary artery calcium was quantified from CT by applying a threshold-based automated algorithm...
March 24, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28231026/late-administration-of-a-palladium-lipoic-acid-complex-poly-mva-modifies-cardiac-mitochondria-but-not-functional-or-structural-manifestations-of-radiation-induced-heart-disease-in-a-rat-model
#5
Vijayalakshmi Sridharan, John W Seawright, Francis J Antonawich, Merrill Garnett, Maohua Cao, Preeti Singh, Marjan Boerma
Exposure of the heart to ionizing radiation can cause adverse myocardial remodeling. In small animal models, local heart irradiation causes persistent alterations in cardiac mitochondrial function and swelling. POLY-MVA is a dietary supplement that contains a palladium lipoic acid complex that targets mitochondrial complex I and has been demonstrated to have greater redox potential than lipoic acid alone. POLY-MVA improves mitochondrial function and anti-oxidant enzyme activity in the aged rat heart. In this study, we tested whether POLY-MVA can mitigate cardiac effects of ionizing radiation...
March 2017: Radiation Research
https://www.readbyqxmd.com/read/28170314/heart-disease-mortality-in-the-life-span-study-1950-2008
#6
Ikuno Takahashi, Yukiko Shimizu, Eric J Grant, John Cologne, Kotaro Ozasa, Kazunori Kodama
Based on the findings from the Radiation Effects Research Foundation's studies of the cohort of Japanese atomic bomb survivors, it has been reported that total-body irradiation at 0.5-1.0 Gy could be responsible for increased rates of mortality from broad-based categories of cardiovascular disease (CVD), i.e., stroke and heart disease. However, CVD consists of various subtypes that have potentially different radiation dose responses, as well as subtype-specific risks that have not been fully evaluated. Potential problems with changes in the coding rules for the International Classification of Diseases (ICD) and the underlying causes and trends in CVD mortality in Japan also need to be considered...
February 7, 2017: Radiation Research
https://www.readbyqxmd.com/read/28151876/late-onset-radiation-induced-constrictive-pericarditis-and-cardiomyopathy-after-radiotherapy-a-case-report
#7
Xiao-Feng Zhuang, Yan-Min Yang, Xiao-Lu Sun, Zhong-Kai Liao, Jie Huang
INTRODUCTION: Radiation-induced heart disease (RIHD) is a serious side effect of cancer treatment, including coronary artery disease, valvular cardiac dysfunction, cardiomyopathy, aortopathy, and chronic constrictive pericarditis. Herein, this case we present was diagnosed as radiation-induced constrictive pericarditis and cardiomyopathy by means of cardiac magnetic resonance (CMR) and transthoracic echocardiogram, finally confirmed by pathology after performing heart transplant operation...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28110593/new-insight-into-mitochondrial-changes-in-vascular-endothelial-cells-irradiated-by-gamma-ray
#8
Shunying Hu, Yajing Gao, Hao Zhou, Fanxuan Kong, Fengjun Xiao, Pingkun Zhou, Yundai Chen
PURPOSE: To investigate alterations of mitochondria in irradiated endothelial cells so that to further elucidate the mechanism underlying radiation-induced heart disease. MATERIALS AND METHODS: Experiments were performed using human umbilical vein endothelial cells (HUVECs). HUVECs were irradiated with single gamma ray dose of 0Gy, 5Gy, 10Gy, 20Gy, respectively. Apoptosis was assessed by flow cytometry at 24h, 48h, 72h post-irradiation, respectively. The intracellular reactive oxygen species (ROS) was measured with 2',7'-dichlorofluorescein-diacetate (DCFH-DA) at 24h post- irradiation...
January 23, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28095154/radiation-induced-heart-disease-after-breast-cancer-treatment-how-big-a-problem-and-how-much-can-and-should-we-try-to-reduce-it
#9
Abram Recht
No abstract text is available yet for this article.
April 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28068236/cerebrovascular-diseases-in-childhood-cancer-survivors-role-of-the-radiation-dose-to-willis-circle-arteries
#10
Chiraz El-Fayech, Nadia Haddy, Rodrigue Sètchéou Allodji, Cristina Veres, Fara Diop, Amar Kahlouche, Damien Llanas, Angela Jackson, Carole Rubino, Catherine Guibout, Hélène Pacquement, Odile Oberlin, Cécile Thomas-Teinturier, Pierre-Yves Scarabin, Jean Chavaudra, Dimitry Lefkopoulos, Maurice Giroud, Yannick Bejot, Valérie Bernier, Christian Carrie, Ibrahima Diallo, Florent de Vathaire
BACKGROUND AND PURPOSE: The aim of this study was to investigate the role of radiation dose received to the circle of Willis (WC) during radiation therapy (RT) and of potential dose-response modifiers on the risk of stroke after treatment of childhood cancer. METHODS: We evaluated the risk factors for stroke in a cohort of 3172 5-year survivors of childhood cancer who were followed up for a median time of 26 years. Radiation doses to the WC and brain structures were estimated for each of the 2202 children who received RT...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27956409/functional-assessment-of-coronary-artery-disease-using-whole-heart-dynamic-computed-tomographic-perfusion
#11
Logan Hubbard, Benjamin Ziemer, Jerry Lipinski, Bahman Sadeghi, Hanna Javan, Elliott M Groves, Shant Malkasian, Sabee Molloi
BACKGROUND: Computed tomographic (CT) angiography is an important tool for the evaluation of coronary artery disease but often correlates poorly with myocardial ischemia. Current dynamic CT perfusion techniques can assess ischemia but have limited accuracy and deliver high radiation dose. Therefore, an accurate, low-dose, dynamic CT perfusion technique is needed. METHODS AND RESULTS: A total of 20 contrast-enhanced CT volume scans were acquired in 5 swine (40±10 kg) to generate CT angiography and perfusion images...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27938516/radiation-induced-heart-disease-a-practical-guide-to-diagnosis-and-management
#12
REVIEW
Eoin Donnellan, Dermot Phelan, Cian P McCarthy, Patrick Collier, Milind Desai, Brian Griffin
Radiation-induced heart disease (RIHD) is a recognized late sequela of chest radiotherapy for conditions such as breast cancer and lymphoma and can involve any cardiac structure. Consensus guidelines from the European Association of Cardiovascular Imaging and the American Society of Echocardiography stress the importance of regular screening for the cardiac effects of radiotherapy. However, a gulf remains between these guidelines and clinical practice.
December 2016: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/27919338/effects-of-ionizing-radiation-on-the-heart
#13
Marjan Boerma, Vijayalakshmi Sridharan, Xiao-Wen Mao, Gregory A Nelson, Amrita K Cheema, Igor Koturbash, Sharda P Singh, Alan J Tackett, Martin Hauer-Jensen
This article provides an overview of studies addressing effects of ionizing radiation on the heart. Clinical studies have identified early and late manifestations of radiation-induced heart disease, a side effect of radiation therapy to tumors in the chest when all or part of the heart is situated in the radiation field. Studies in preclinical animal models have contributed to our understanding of the mechanisms by which radiation may injure the heart. More recent observations in human subjects suggest that ionizing radiation may have cardiovascular effects at lower doses than was previously thought...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27908971/13n-ammonia-pet-ct-detection-of-myocardial-perfusion-abnormalities-in-beagle-dogs-after-local-heart-irradiation
#14
Jianbo Song, Rui Yan, Zhifang Wu, Jianguo Li, Min Yan, Xinzhong Hao, Jianzhong Liu, Sijin Li
To determine the potential value of (13)N-ammonia positron emission tomography (PET)/computed tomography (CT) myocardial perfusion imaging (MPI) for detection of myocardial perfusion changes at early stage induced by radiation damage. METHODS: Thirty-six Beagle dogs were randomly divided into the control (n = 18) or the irradiation groups (n = 18). The irradiation group underwent local irradiation to the left ventricular anterior cardiac wall with a single dose of 20 Gy, whereas the control group received sham irradiation...
December 1, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27867461/transesophageal-echocardiography-and-radiation-induced-damages
#15
Marzia Cottini, Vincenzo Polizzi, Paolo Giuseppe Pino, Vitaliano Buffa, Francesco Musumeci
The long-term sequelae of mantle therapy include, especially lung and cardiac disease but also involve the vessels and the organs in the neck and thorax (such as thyroid, aorta, and esophagus). We presented the case of 66-year-old female admitted for congestive heart failure in radiation-induced heart disease. The patient had undergone to massive radiotherapy 42 years ago for Hodgkin's disease (type 1A). Transesophageal echocardiography was performed unsuccessfully with difficulty because of the rigidity and impedance of esophageal walls...
July 2016: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/27842711/-radiation-related-heart-toxicity-update-in-women
#16
REVIEW
S Marlière, E Vautrin, C Saunier, A Chaikh, I Gabelle-Flandin
Breast cancer is a common diagnosis in women and thus women are at risk of radiation-induced heart disease, in particular during radiotherapy for left breast cancer and when the internal mammary chain is included. Rates of major cardiac events increase with younger age at the time of irradiation, diagnosis before 1990s, higher radiation doses, coexisting cardiovascular risk factors and adjuvant cardiotoxic chemotherapy. Radiation-induced heart disease comprises a spectrum of cardiac pathologies, including pericardial disease, cardiomyopathy, coronary artery disease and valvular disease...
December 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27824014/intramural-hematoma-versus-thrombus-radiation-induced-heart-disease-results-in-mass-formation-after-radiofrequency-ablation
#17
Li-Yun Feng, Xu-Dong Song, Lei Liu, Xian-Bao Wang, Peng Liu, Xiu-Li Zhang, Yi-Jun Zhou, Dong-Dong Que, Wen-Jie Yu, Yuan-Qing Li, Ping-Zhen Yang
No abstract text is available yet for this article.
November 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27741117/radiation-induced-heart-disease-in-lung-cancer-radiotherapy-a-dosimetric-update
#18
REVIEW
Xin Ming, Yuanming Feng, Chengwen Yang, Wei Wang, Ping Wang, Jun Deng
BACKGROUND: Radiation-induced heart disease (RIHD), which affects the patients' prognosis with both acute and late side effects, has been published extensively in the radiotherapy of breast cancer, lymphoma and other benign diseases. Studies on RIHD in lung cancer radiotherapy, however, are less extensive and clear even though the patients with lung cancer are delivered with higher doses to the heart during radiation treatment. METHODS: In this article, after extensive literature search and analysis, we reviewed the current evidence on RIHD in lung cancer patients after their radiation treatments and investigated the potential risk factors for RIHD as compared to other types of cancers...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27721934/novel-concepts-in-radiation-induced-cardiovascular-disease
#19
REVIEW
Jason R Cuomo, Gyanendra K Sharma, Preston D Conger, Neal L Weintraub
Radiation-induced cardiovascular disease (RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy (RT). Cardiovascular complications include effusive or constrictive pericarditis, cardiomyopathy, valvular heart disease, and coronary/vascular disease. These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels. Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD, the increasing number of long-term cancer survivors, including those treated with older higher-dose RT regimens, will ensure a steady flow of afflicted patients for the foreseeable future...
September 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27681888/a-single-dose-escalation-study-to-evaluate-the-safety-and-pharmacokinetics-of-orally-administered-des-aspartate-angiotensin-i-in-healthy-subjects
#20
Ko-Onn Lee, Chin-Meng Khoo, Balram Chowbay, Yiong-Huak Chan, Meng-Kwoon Sim
Des-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT1 receptor and antagonises the deleterious actions of angiotensin II. DAA-I attenuates animal models of human disease in which angiotensin II has been implicated, such as cardiac hypertrophy, neointima formation, arteriosclerosis, renal failure, post-infarction injuries, diabetes, viral infection, chemical-induced inflammation, heat stroke, cancer, and gamma radiation lethality...
December 2016: Drugs in R&D
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