keyword
MENU ▼
Read by QxMD icon Read
search

Radiation Induced Heart Disease

keyword
https://www.readbyqxmd.com/read/29556748/radiation-induced-cardiovascular-toxicity-mechanisms-prevention-and-treatment
#1
REVIEW
Johan Spetz, Javid Moslehi, Kristopher Sarosiek
PURPOSE OF REVIEW: Ionizing radiation is a highly effective treatment for a wide range of malignancies, yet the cardiovascular (CV) toxicity that can result from chest radiotherapy impairs the long-term health of cancer survivors and can be a limiting factor for its use. Despite over 100 years of successful clinical use, the mechanisms by which high-energy photons damage critical components within cells of the heart's myocardium, pericardium, vasculature, and valves remain unclear. RECENT FINDINGS: Recent studies exploring the acute and chronic effects of radiation therapy on cardiac and vascular tissue have provided new insights into the development and progression of heart disease, including the identification and understanding of age- and complication-associated risk factors...
March 20, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29494295/treating-cardiovascular-complications-of-radiotherapy-a-role-for-new-pharmacotherapies
#2
Nathalie Donis, Cécile Oury, Marie Moonen, Patrizio Lancellotti
Available data indicate that survivors of breast cancer and Hodgkin lymphoma who received mediastinal radiotherapy are at increased risk of developing radiation-induced cardiovascular diseases (RICVD) one or two decades after treatment. Although the risk with modern radiation treatment is likely to be lower in these patient groups, cardiotoxicity is still observed in a subset of patients. In addition, radiation-associated cardiovascular complications can, in the future, extend to other groups of cancer patients who are treated for tumors that are localized near the heart...
March 1, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29475525/high-let-radiation-shows-no-major-cellular-and-functional-effects-on-primary-cardiomyocytes-in-vitro
#3
Anja Heselich, Johannes L Frieß, Sylvia Ritter, Naja P Benz, Paul G Layer, Christiane Thielemann
It is well known that ionizing radiation causes adverse effects on various mammalian tissues. However, there is little information on the biological effects of heavy ion radiation on the heart. In order to fill this gap, we systematically examined DNA-damage induction and repair, as well as proliferation and apoptosis in avian cardiomyocyte cultures irradiated with heavy ions such as titanium and iron, relevant for manned space-flight, and carbon ions, as used for radiotherapy. Further, and to our knowledge for the first time, we analyzed the effect of heavy ion radiation on the electrophysiology of primary cardiomyocytes derived from chicken embryos using the non-invasive microelectrode array (MEA) technology...
February 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29406998/prophylactic-use-of-colchicine-in-preventing-radiation-induced-coronary-artery-disease
#4
T O'Herron, J Lafferty
Radiation therapy is one of the primary treatments in fighting breast cancer, one of the most common cancers in the US. One of the dose limiting factors of this therapy is radiation induced heart damage that results from mediastinal radiation. Recently statins, a medication typically used to lower cholesterol levels, have been suggested as a prophylactic treatment to potentially mitigate this process. Similarly, we hypothesized whether colchicine, an anti-inflammatory medication that is presently used in the treatment of gout and pericarditis, might be used to prevent coronary artery disease induced by radiation therapy...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29405732/histopathological-efficiency-of-amifostine-in-radiation%C3%A2-induced-heart-disease-in-rats
#5
I Gurses, M Ozeren, M Serin, N Yucel, H S Erkal
OBJECTIVE: Amifositine is a phosphorylated thiol that holds its radioprotective actions by several indirect mechanisms. The purpose of this study was to evaluate histopathologically whether amifositine administration prior to irradiation would have a long‑term protective effect on heart tissue in an experimental rat model. METHODS: Single dose of 18 Gy radiation and sham radiation exposure were used in related groups. A dose of 200 mg/kg of amifostine was injected intraperitoneally 30 min prior to radiation exposure...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29249430/prevalence-of-takayasu-arteritis-in-young-women-with-acute-ischemic-heart-disease
#6
Giulio Cavalli, Alessandro Tomelleri, Davide Di Napoli, Elena Baldissera, Lorenzo Dagna
OBJECTIVES: Takayasu arteritis (TA), a systemic vasculitis typically occurring in female patients aged ≤40, can affect coronary arteries and cause ischemic heart disease (IHD). In this study, we investigated the prevalence of TA in young women presenting with IHD in the Emergency Department. METHODS: We evaluated hospital records of 158,860 consecutive female patients aged <40, who accessed the Emergency Department of our institution over 8 consecutive years (2007-2015)...
February 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29203042/-treatment-of-radiation-induced-iliofemoral-arterial-complications-with-groin-radionecrosis
#7
J-M Fichelle
Long-term iliofemoral complications induced by radiation include vascular (arterial and venous) lesions, nervous lesions and soft tissue loss that can be cutaneous and subcutaneous and potentially lead to radionecrosis with vessel exposure. We present five cases of groin radionecrosis. There were three men and two women (age 30-73 years). Radiotherapy had been delivered 15 years earlier in three cases, and 2 years earlier in two cases. Symptoms were intermittent claudication (n=1), critical ischemia (n=1), and septic hemorrhage (n=1)...
December 2017: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29151482/radiation-induced-coronary-artery-disease-manifested-at-very-late-phase
#8
Shu Inami, Shichiro Abe, Ryo Watanabe, Fumiya Saito, Masashi Sakuma, Akiko Haruyama, Hirohisa Amano, Takuo Arikawa, Shigeru Toyoda, Teruo Inoue
We report the case of a 51-year-old female, in whom coronary artery disease such as occlusion of septal perforators was manifested, on the occasion of hospitalization with congestive heart failure. The patient had a history of radiation therapy for a mediastinal tumor 19 years previously. As she had no conventional coronary risk factors, the cause of the coronary artery disease is thought to have been related to the radiation therapy. As survival rates of cancer patients improve as a consequence of therapeutic advances, we should be aware of the possibility of coronary artery disease as a very late complication of radiation therapy, even in patients who have no coronary risk factors...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29145955/cardiovascular-complications-of-cancer-therapy-best-practices-in-diagnosis-prevention-and-management-part-2
#9
REVIEW
Hui-Ming Chang, Tochukwu M Okwuosa, Tiziano Scarabelli, Rohit Moudgil, Edward T H Yeh
In this second part of a 2-part review, we will review cancer or cancer therapy-associated systemic and pulmonary hypertension, QT prolongation, arrhythmias, pericardial disease, and radiation-induced cardiotoxicity. This review is based on a MEDLINE search of published data, published clinical guidelines, and best practices in major cancer centers. Newly developed targeted therapy can exert off-target effects causing hypertension, thromboembolism, QT prolongation, and atrial fibrillation. Radiation therapy often accelerates atherosclerosis...
November 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29131805/management-of-radiation-induced-valvular-heart-disease-due-to-hodgkin-s-lymphoma-in-the-modern-area
#10
Elise Paven, Claire Cimadevilla, Marina Urena, Marie-Pierre Dilly, Patrick Nataf, Richard Raffoul, Dominique Himbert, Alec Vahanian, David Messika-Zeitoun
AIMS: Series purely related to radiation-induced valvular heart diseases (RI-VHD) due to Hodgkin's lymphoma are scarce. We sought to report their contemporary management at the area of transcatheter therapies. METHODS AND RESULTS: We retrospectively enrolled all consecutive patients who underwent a surgical/transcatheter procedure between 2006 and 2016 at our institution for symptomatic RI-VHD due to Hodgkin's lymphoma. Management was left at the discretion of the heart team...
November 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29053152/heart-in-space-effect-of-the-extraterrestrial-environment-on-the-cardiovascular-system
#11
REVIEW
Richard L Hughson, Alexander Helm, Marco Durante
National space agencies and private corporations aim at an extended presence of humans in space in the medium to long term. Together with currently suboptimal technology, microgravity and cosmic rays raise health concerns about deep-space exploration missions. Both of these physical factors affect the cardiovascular system, whose gravity-dependence is pronounced. Heart and vascular function are, therefore, susceptible to substantial changes in weightlessness. The altered cardiovascular function in space causes physiological problems in the postflight period...
March 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29038417/role-of-exogenous-phosphocreatine-in-chemotherapy-induced-cardiomyopathy
#12
Swapnil Parve, Gulnaz I Aliakberova, Albert A Gylmanov, Diana I Abdulganieva
The 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) regimen is widely used in the management of breast cancer. The common cardiotoxic effects of doxorubicin include congestive heart failure and left ventricular dysfunction, and those of cyclophosphamide include pericarditis, myocarditis, and congestive heart failure. It has been postulated that cardiotoxicity of 5-fluorouracil presents as coronary artery diseases (eg, angina). Cardiomyopathy is a common outcome following treatment with the FAC regimen...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29025547/contemporary-techniques-of-pericardiectomy-for-pericardial-disease
#13
REVIEW
Pouya Hemmati, Kevin L Greason, Hartzell V Schaff
Pericardiectomy is a potentially curative treatment for constrictive pericarditis. We use a median sternotomy and believe that adequate resection involves removal of the diaphragmatic pericardium and the anterior pericardium. Late outcomes depend on severity of right-sided heart failure preoperatively, the etiology of constrictive pericarditis, and adequate pericardial resection. Late results are excellent in patients with idiopathic disease or those with pericarditis secondary to prior cardiac operations. However, survival is reduced in those with radiation-induced constrictive pericarditis, primarily owing to additional secondary effects of radiation on cardiac valves, epicardial coronary arteries, and ventricular myocardium where fibrosis may cause associated restrictive cardiomyopathy...
November 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/29019475/orofacial-pain-associated-with-vasospastic-angina-a-case-report
#14
Makoto Adachi, Mio Hayashi, Tomonori Segawa, Takahiko Yamaki, Yasunori Muramatsu, Shinichiro Sumitomo
The primary symptom of ischemic heart disease is typically chest pain, but in some cases, this pain may radiate to the maxillofacial region. This article describes the case of a 44-year-old man with orofacial pain of cardiac origin. The patient was suspected to be suffering from cardiac disease by the oral and maxillofacial surgeon and was referred to a cardiologist, where he received a heart examination. The patient was diagnosed by means of cardiac catheterization as having coronary spastic angina. During catheterization, intracoronary ergonovine maleate induced orofacial pain that was almost the same in character and intensity as the patient's first episode...
2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28976223/proteomics-landscape-of-radiation-induced-cardiovascular-disease-somewhere-over-the-paradigm
#15
Omid Azimzadeh, Soile Tapio
Epidemiological studies clearly show that thoracic or whole body exposure to ionizing radiation increases the risk of cardiac morbidity and mortality. Radiation-induced cardiovascular disease (CVD) has been intensively studied during the last ten years but the underlying molecular mechanisms are still poorly understood. Areas covered: Heart proteomics is a powerful tool holding promise for the future research. The central focus of this review is to compare proteomics data on radiation-induced CVD with data arising from proteomics of healthy and diseased cardiac tissue in general...
November 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28937442/orally-active-epoxyeicosatrienoic-acid-analogs
#16
William B Campbell, John D Imig, James M Schmitz, John R Falck
Biologically active epoxyeicosatrienoic acid (EET) regioisomers are synthesized from arachidonic acid by cytochrome P450 epoxygenases of endothelial, myocardial, and renal tubular cells. EETs relax vascular smooth muscle and decrease inflammatory cell adhesion and cytokine release. Renal EETs promote sodium excretion and vasodilation to decrease hypertension. Cardiac EETs reduce infarct size after ischemia-reperfusion injury and decrease fibrosis and inflammation in heart failure. In diabetes, EETs improve insulin sensitivity, increase glucose tolerance, and reduce the renal injury...
October 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28916844/left-sided-breast-cancer-and-risks-of-secondary-lung-cancer-and-ischemic-heart-disease-effects-of-modern-radiotherapy-techniques
#17
Stefanie Corradini, Hendrik Ballhausen, Helmut Weingandt, Philipp Freislederer, Stephan Schönecker, Maximilian Niyazi, Cristoforo Simonetto, Markus Eidemüller, Ute Ganswindt, Claus Belka
PURPOSE: Modern breast cancer radiotherapy techniques, such as respiratory-gated radiotherapy in deep-inspiration breath-hold (DIBH) or volumetric-modulated arc radiotherapy (VMAT) have been shown to reduce the high dose exposure of the heart in left-sided breast cancer. The aim of the present study was to comparatively estimate the excess relative and absolute risks of radiation-induced secondary lung cancer and ischemic heart disease for different modern radiotherapy techniques. METHODS: Four different treatment plans were generated for ten computed tomography data sets of patients with left-sided breast cancer, using either three-dimensional conformal radiotherapy (3D-CRT) or VMAT, in free-breathing (FB) or DIBH...
September 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28871993/predicted-rate-of-secondary-malignancies-following-adjuvant-proton-versus-photon-radiation-therapy-for-thymoma
#18
J Vogel, L Lin, L A Litzky, A T Berman, C B Simone
PURPOSE: Thymic malignancies are the most common tumors of the anterior mediastinum. The benefit of adjuvant radiation therapy for stage II disease remains controversial, and patients treated with adjuvant radiation therapy are at risk of late complications, including radiation-induced secondary malignant neoplasms (SMNs), that may reduce the overall benefit of treatment. We assess the risk of predicted SMNs following adjuvant proton radiation therapy compared with photon radiation therapy after resection of stage II thymic malignancies to determine whether proton therapy improves the risk-benefit ratio...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28870399/the-risk-of-reoperative-cardiac-surgery-in-radiation-induced-valvular-disease
#19
Julius I Ejiofor, Fernando Ramirez-Del Val, Anju Nohria, Anthony Norman, Siobhan McGurk, Sary F Aranki, Prem Shekar, Lawrence H Cohn, Tsuyoshi Kaneko
OBJECTIVE: Mediastinal radiation therapy (MRT) increases the risk for adverse outcomes after cardiac surgery and is not incorporated in the Society of Thoracic Surgeons (STS) risk algorithm. We aimed to quantify the surgical risk conferred by MRT in patients undergoing primary and reoperative valvular operations. METHODS: A retrospective analysis of 261 consecutive patients with prior MRT who underwent valvular operations between January 2002 and May 2015. Short- and long-term outcomes were compared for STS predicted risk of mortality, surgery type, gender, year of surgery, and age-matched patients stratified by reoperative status...
July 29, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28845879/-a-case-of-severe-left-main-isolated-stenosis-in-a-young-woman-with-previous-history-of-non-hodgkin-lymphoma
#20
Sebastian Cinconze, Lucia Coppini, Daniela Lina, Iacopo Tadonio, Maria Alberta Cattabiani, Emilia Solinas, Luigi Vignali, Alberto Menozzi
We report the case of a 34-year-old female treated with radiotherapy and chemotherapy for non-Hodgkin lymphoma at the age of 16. The patient came to our attention because of progressive dyspnea on effort and a positive result on a pharmacologic stress echo test. Coronary angiography revealed focal critical ostial stenosis of the left main coronary artery. Considering the high surgical risk due to possible post-radiation thoracic adherence and the young patient age, she underwent successful stenting of the left main stenosis with drug-eluting stent, followed by an intravascular ultrasound-guided post-dilation and final kissing balloon inflation...
September 2017: Giornale Italiano di Cardiologia
keyword
keyword
78364
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"