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https://www.readbyqxmd.com/read/29684005/in-vivo-clonal-analysis-reveals-spatiotemporal-regulation-of-thalamic-nucleogenesis
#1
Samuel Z H Wong, Earl Parker Scott, Wenhui Mu, Xize Guo, Ella Borgenheimer, Madeline Freeman, Guo-Li Ming, Qing-Feng Wu, Hongjun Song, Yasushi Nakagawa
The thalamus, a crucial regulator of cortical functions, is composed of many nuclei arranged in a spatially complex pattern. Thalamic neurogenesis occurs over a short period during mammalian embryonic development. These features have hampered the effort to understand how regionalization, cell divisions, and fate specification are coordinated and produce a wide array of nuclei that exhibit distinct patterns of gene expression and functions. Here, we performed in vivo clonal analysis to track the divisions of individual progenitor cells and spatial allocation of their progeny in the developing mouse thalamus...
April 23, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29683523/white-matter-degeneration-profile-in-the-cognitive-cortico-subcortical-tracts-in-parkinson-s-disease
#2
Alexandru Hanganu, Jean-Christophe Houde, Vladimir S Fonov, Clotilde Degroot, Beatriz Mejia-Constain, Anne-Louise Lafontaine, Valérie Soland, Sylvain Chouinard, Louis D Collins, Maxime Descoteaux, Oury Monchi
BACKGROUND: In Parkinson's disease cognitive impairment is an early nonmotor feature, but it is still unclear why some patients are able to maintain their cognitive performance at normal levels, as quantified by neuropsychological tests, whereas others cannot. The objectives of this study were to perform a cross-sectional study and analyze the white matter changes in the cognitive and motor bundles in patients with Parkinson's disease. METHODS: Sixteen Parkinson's disease patients with normal cognitive performance, 19 with mild cognitive impairment (based on their performance of 1...
April 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29681289/ir-compatible-pdms-microfluidic-devices-for-monitoring-of-enzyme-kinetics
#3
Monpichar Srisa-Art, Scott D Noblitt, Amber T Krummel, Charles S Henry
Coupling infrared (IR) spectroscopy to microfluidic devices provides a powerful tool for characterizing complex chemical and biochemical reactions. Examples of microfluidic devices coupled with infrared spectroscopy have been limited, however, largely due to the difficulties associated with fabricating systems in common infrared transparent materials like CaF2 . Recent reports have shown that polydimethylsiloxane (PDMS) can be used as an IR transparent substrate when fabricated with thin layers. The use of soft lithography with PDMS expands the library of possible designs that can be achieved for IR measurements in microfluidics...
August 27, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29678806/a-novel-algorithm-for-determining-the-contextual-characteristics-of-movement-behaviors-by-combining-accelerometer-features-and-wireless-beacons-development-and-implementation
#4
Daniele Magistro, Salvatore Sessa, Andrew P Kingsnorth, Adam Loveday, Alessandro Simeone, Massimiliano Zecca, Dale W Esliger
BACKGROUND: Unfortunately, global efforts to promote "how much" physical activity people should be undertaking have been largely unsuccessful. Given the difficulty of achieving a sustained lifestyle behavior change, many scientists are reexamining their approaches. One such approach is to focus on understanding the context of the lifestyle behavior (ie, where, when, and with whom) with a view to identifying promising intervention targets. OBJECTIVE: The aim of this study was to develop and implement an innovative algorithm to determine "where" physical activity occurs using proximity sensors coupled with a widely used physical activity monitor...
April 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29678018/advantages-of-a-web-based-real-time-bed-management-system-for-hospital-admission-monitoring-in-iran
#5
Somayeh Abedian, Ehsan Bitaraf, Marjan Askari
Lack of up-to-date information of hospitals beds, specifically in emergencies, is a significant problem in many large countries; The Ministry of Health and Medical Education of Iran (MOHME) designed and implemented a dynamic system that reports the status of beds in 2012. This system created great opportunities for national bed management, including real-time hospital admission monitoring, especially for emergency departments, ICUs and CCUs. Therefore, an additional online system was planned to be implemented for monitoring hospital admissions, including a national alert system...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677973/yorwalk-desiging-a-smartphone-exercise-application-for-people-with-intermittent-claudication
#6
Ahmed Shalan, Abubakar Abdulrahman, Ibrahim Habli, Garry Tew, Andrew Thompson
Peripheral Arterial Disease (PAD) is a chronic cardiovascular disease. It is highly prevalent in older adults. Mobile Health (mHealth) and Telehealth technologies are considered two central digital solutions for enabling patient-centred care. There is evidence that physical activity apps can improve health outcomes in adults. The aim of this project is to develop a prototype of smart phone app to target patients with PAD, which we named YORwalK, to promote exercise and track changes in walking ability in this population...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677367/stable-microsaccades-and-microsaccade-induced-global-alpha-band-phase-reset-across-the-life-span
#7
Ying Gao, Carl Huber, Bernhard A Sabel
Purpose: To understand the effect of aging on microsaccade functions and brain physiologic responses, we quantified microsaccades and their physiologic correlates (including their interaction with alpha band brain oscillation) in normal subjects of different ages. Methods: Twenty-two normally sighted young (18 to 29 years), 22 middle-aged (31 to 55 years), and 22 elderly subjects (56 to 77 years) participated in this cross-sectional study. Dense array EEG and high-resolution eye-tracking data were simultaneously recorded during a fixation task...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677335/the-eye-tracks-the-aesthetic-appeal-of-sentences
#8
Hideyuki Hoshi, Winfried Menninghaus
Eye-tracking parameters (fixation and pupillary responses) have been shown to be modulated by the aesthetic perception and evaluation of visual and auditory artworks (e.g., paintings, music). The present study investigated whether similar effects can be found in visual text processing. Participants read four groups of short sentences in which a key predictor of aesthetic liking, i.e., familiarity, was systematically modified to four degrees. Across all four groups, the sentences moreover varied with regard to featuring or not featuring meter...
March 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29674309/measuring-risky-driving-behavior-using-an-mhealth-smartphone-app-development-and-evaluation-of-gforce
#9
Raisa Z Freidlin, Amisha D Dave, Benjamin G Espey, Sean T Stanley, Marcial A Garmendia, Randall Pursley, Johnathon P Ehsani, Bruce G Simons-Morton, Thomas J Pohida
BACKGROUND: Naturalistic driving studies, designed to objectively assess driving behavior and outcomes, are conducted by equipping vehicles with dedicated instrumentation (eg, accelerometers, gyroscopes, Global Positioning System, and cameras) that provide continuous recording of acceleration, location, videos, and still images for eventual retrieval and analyses. However, this research is limited by several factors: the cost of equipment installation; management and storage of the large amounts of data collected; and data reduction, coding, and analyses...
April 19, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29673853/biventricular-dyssynchrony-on-cardiac-magnetic-resonance-imaging-and-its-correlation-with-myocardial-deformation-ventricular-function-and-objective-exercise-capacity-in-patients-with-repaired-tetralogy-of-fallot
#10
Pantelis Kalaitzidis, Stefan Orwat, Aleksander Kempny, Radke Robert, Brigitte Peters, Samir Sarikouch, Philipp Beerbaum, Helmut Baumgartner, Gerhard-Paul Diller
BACKGROUND: Electrical dyssynchrony and prolonged QRS duration are common in patients with repaired tetralogy of Fallot (ToF). It has been linked to increased risk of sudden cardiac death and right ventricular (RV) dysfunction. We investigated myocardial dyssynchrony using cardiac magnetic resonance imaging (CMR) and feature tracking analysis (FT) in this setting and compared it to myocardial deformation, conventional parameters of ventricular dysfunction and clinical parameters. METHODS AND RESULTS: Patients underwent standardized CMR investigations as part of a nationwide study...
April 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29673156/feature-extraction-for-track-section-status-classification-based-on-ugw-signals
#11
Lei Yuan, Yuan Yang, Álvaro Hernández, Lin Shi
Track status classification is essential for the stability and safety of railway operations nowadays, when railway networks are becoming more and more complex and broad. In this situation, monitoring systems are already a key element in applications dedicated to evaluating the status of a certain track section, often determining whether it is free or occupied by a train. Different technologies have already been involved in the design of monitoring systems, including ultrasonic guided waves (UGW). This work proposes the use of the UGW signals captured by a track monitoring system to extract the features that are relevant for determining the corresponding track section status...
April 17, 2018: Sensors
https://www.readbyqxmd.com/read/29672531/embryominer-a-new-framework-for-interactive-knowledge-discovery-in-large-scale-cell-tracking-data-of-developing-embryos
#12
Benjamin Schott, Manuel Traub, Cornelia Schlagenhauf, Masanari Takamiya, Thomas Antritter, Andreas Bartschat, Katharina Löffler, Denis Blessing, Jens C Otte, Andrei Y Kobitski, G Ulrich Nienhaus, Uwe Strähle, Ralf Mikut, Johannes Stegmaier
State-of-the-art light-sheet and confocal microscopes allow recording of entire embryos in 3D and over time (3D+t) for many hours. Fluorescently labeled structures can be segmented and tracked automatically in these terabyte-scale 3D+t images, resulting in thousands of cell migration trajectories that provide detailed insights to large-scale tissue reorganization at the cellular level. Here we present EmbryoMiner, a new interactive open-source framework suitable for in-depth analyses and comparisons of entire embryos, including an extensive set of trajectory features...
April 19, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29671792/a-method-for-extracting-road-boundary-information-from-crowdsourcing-vehicle-gps-trajectories
#13
Wei Yang, Tinghua Ai, Wei Lu
Crowdsourcing trajectory data is an important approach for accessing and updating road information. In this paper, we present a novel approach for extracting road boundary information from crowdsourcing vehicle traces based on Delaunay triangulation (DT). First, an optimization and interpolation method is proposed to filter abnormal trace segments from raw global positioning system (GPS) traces and interpolate the optimization segments adaptively to ensure there are enough tracking points. Second, constructing the DT and the Voronoi diagram within interpolated tracking lines to calculate road boundary descriptors using the area of Voronoi cell and the length of triangle edge...
April 19, 2018: Sensors
https://www.readbyqxmd.com/read/29669563/a-comparison-of-both-dense-and-feature-tracking-techniques-with-tagging-for-the-cardiovascular-magnetic-resonance-assessment-of-myocardial-strain
#14
J Jane Cao, Nora Ngai, Lynette Duncanson, Joshua Cheng, Kathleen Gliganic, Qizhi Chen
BACKGROUND: Myocardial strain is increasingly recognized as an important assessment for myocardial function. In addition, it also improves outcome prediction. However, there is lack of standardization in strain evaluation by cardiovascular magnetic resonance (CMR). In this study we compared strain values using multiple techniques and multiple vendor products. METHODS: Prospectively recruited patients with cardiomyopathy of diverse etiology (N = 77) and healthy controls (N = 10) underwent CMR on a 1...
April 19, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29668348/phosphatidylserine-and-gtpase-activation-control-cdc42-nanoclustering-to-counter-dissipative-diffusion
#15
Elodie Sartorel, Caner Ünlü, Mini Jose, Aurélie Massoni-Laporte, Julien Meca, Jean-Baptiste Sibarita, Derek McCusker
The anisotropic organization of plasma membrane constituents is indicative of mechanisms that drive the membrane away from equilibrium. However, defining these mechanisms is challenging due to the short spatio-temporal scales at which diffusion operates. Here, we use high-density single protein tracking combined with photoactivation localization microscopy (sptPALM) to monitor Cdc42 in budding yeast, a system in which Cdc42 exhibits anisotropic organization. Cdc42 exhibited reduced mobility at the cell pole, where it was organized in nanoclusters...
April 18, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29666460/cortical-classification-with-rhythm-entropy-for-error-processing-in-cocktail-party-environment-based-on-scalp-eeg-recording
#16
Yin Tian, Wei Xu, Li Yang
Using single-trial cortical signals calculated by weighted minimum norm solution estimation (WMNE), the present study explored a feature extraction method based on rhythm entropy to classify the scalp electroencephalography (EEG) signals of error response from that of correct response during performing auditory-track tasks in cocktail party environment. The classification rate achieved 89.7% with single-trial (≈700 ms) when using support vector machine(SVM) with the leave-one-out-cross-validation (LOOCV)...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664602/engineering-persistent-luminescence-nanoparticles-for-biological-applications-from-biosensing-bioimaging-to-theranostics
#17
Shao-Kai Sun, He-Fang Wang, Xiu-Ping Yan
Persistent luminescence nanoparticles (PLNPs) are unique optical materials emitting long-lasting luminescence after ceasing excitation. Such a unique optical feature allows luminescence detection without constant external illumination to avoid the interferences of autofluorescence and scattering light from biological fluids and tissues. Besides, near-infrared (NIR) PLNPs have advantages of deep penetration and the reactivation of the persistent luminescence (PL) by red or NIR light. These features make the application of NIR-emitting PLNPs in long-term bioimaging no longer limited by the lifetime of PL...
April 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29662947/cortical-measures-of-phoneme-level-speech-encoding-correlate-with-the-perceived-clarity-of-natural-speech
#18
Giovanni M Di Liberto, Michael J Crosse, Edmund C Lalor
In real-world environments, humans comprehend speech by actively integrating prior knowledge (P) and expectations with sensory input. Recent studies have revealed effects of prior information in temporal and frontal cortical areas and have suggested that these effects are underpinned by enhanced encoding of speech-specific features, rather than a broad enhancement or suppression of cortical activity. However, in terms of the specific hierarchical stages of processing involved in speech comprehension, the effects of integrating bottom-up sensory responses and top-down predictions are still unclear...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29662633/tracking-cellular-and-molecular-changes-in-a-species-specific-manner-during-experimental-tumor-progression-in-vivo
#19
Emilie Indersie, Katarzyna B Hooks, Caroline Capdevielle, Monique Fabre, Nathalie Dugot-Senant, Angélique Desplat, Sébastien Lepreux, Aksam Merched, Christophe F Grosset, Martin Hagedorn
Hepatoblastoma (HBL) is a pediatric liver cancer with defined molecular alterations driving its progression. Here, we describe an animal model for HBL on the chick chorioallantoic membrane (CAM), which recapitulates relevant features of HBL in patients. Expression of classic tumor-associated proteins such as β-catenin, EpCAM and CK19 was maintained in acini-like organized tumors on CAM, as was synthesis of AFP, a tumor marker used for monitoring patient response. RNA sequencing revealed an unexpected molecular evolution of HBL cells on the CAM, with significant deregulation of more than 6,000 genes including more than half of all HOX genes...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661549/adaptive-nonsingular-terminal-sliding-mode-controller-for-micro-nanopositioning-systems-driven-by-linear-piezoelectric-ceramic-motors
#20
Alireza Safa, Reza Yazdanpanah Abdolmalaki, Saeed Shafiee, Behzad Sadeghi
In the field of nanotechnology, there is a growing demand to provide precision control and manipulation of devices with the ability to interact with complex and unstructured environments at micro/nano-scale. As a result, ultrahigh-precision positioning stages have been turned into a key requirement of nanotechnology. In this paper, linear piezoelectric ceramic motors (LPCMs) are adopted to drive micro/nanopositioning stages since they have the ability to achieve high precision in addition to being versatile to be implemented over a wide range of applications...
April 13, 2018: ISA Transactions
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