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https://www.readbyqxmd.com/read/29040403/age-related-changes-in-temporal-processing-of-rapidly-presented-sound-sequences-in-the-macaque-auditory-cortex
#1
Ng Chi-Wing, Gregg H Recanzone
The mammalian auditory cortex is necessary to resolve temporal features in rapidly-changing sound streams. This capability is crucial for speech comprehension in humans and declines with normal aging. Nonhuman primate studies have revealed detrimental effects of normal aging on the auditory nervous system, and yet the underlying influence on temporal processing remains less well-defined. Therefore, we recorded from the core and lateral belt areas of auditory cortex when awake young and old monkeys listened to tone-pip and noise-burst sound sequences...
October 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29036886/model-based-real-time-non-rigid-tracking
#2
Sebastián Bronte, Luis M Bergasa, Daniel Pizarro, Rafael Barea
This paper presents a sequential non-rigid reconstruction method that recovers the 3D shape and the camera pose of a deforming object from a video sequence and a previous shape model of the object. We take PTAM (Parallel Mapping and Tracking), a state-of-the-art sequential real-time SfM (Structure-from-Motion) engine, and we upgrade it to solve non-rigid reconstruction. Our method provides a good trade-off between processing time and reconstruction error without the need for specific processing hardware, such as GPUs...
October 14, 2017: Sensors
https://www.readbyqxmd.com/read/29036531/spatkin-a-simulator-for-rule-based-modeling-of-biomolecular-site-dynamics-on-surfaces
#3
Marek Kochanczyk, William S Hlavacek, Tomasz Lipniacki
Summary: Rule-based modeling is a powerful approach for studying biomolecular site dynamics. Here, we present SPATKIN, a general-purpose simulator for rule-based modeling in two spatial dimensions. The simulation algorithm is a lattice-based method that tracks Brownian motion of individual molecules and the stochastic firing of rule-defined reaction events. Because rules are used as event generators, the algorithm is network-free, meaning that it does not require to generate the complete reaction network implied by rules prior to simulation...
July 17, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036527/isyte-2-0-a-database-for-expression-based-gene-discovery-in-the-eye
#4
Atul Kakrana, Andrian Yang, Deepti Anand, Djordje Djordjevic, Deepti Ramachandruni, Abhyudai Singh, Hongzhan Huang, Joshua W K Ho, Salil A Lachke
Although successful in identifying new cataract-linked genes, the previous version of the database iSyTE (integrated Systems Tool for Eye gene discovery) was based on expression information on just three mouse lens stages and was functionally limited to visualization by only UCSC-Genome Browser tracks. To increase its efficacy, here we provide an enhanced iSyTE version 2.0 (URL: http://research.bioinformatics.udel.edu/iSyTE) based on well-curated, comprehensive genome-level lens expression data as a one-stop portal for the effective visualization and analysis of candidate genes in lens development and disease...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036067/analyzing-visual-search-observers-using-eye-tracking-data-for-digital-breast-tomosynthesis-images
#5
Zhengqiang Jiang, Mini Das, Howard C Gifford
Visual-search (VS) model observers have the potential to provide reliable predictions of human-observer performance in detection-localization tasks. The purpose of this work was to examine some characteristics of human gaze on breast images with the goal of informing the design of our VS observers. Using a helmet-mounted eye-tracking system, we recorded the movement of gaze from human observers as they searched for masses in sets of 2D digital breast tomosynthesis (DBT) images. The masses in this study were of a single profile...
June 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035607/accuracy-of-w-recovery-kinetics-in-high-performance-cyclists-modelling-intermittent-work-capacity
#6
Jason C Bartram, Dominic Thewlis, David T Martin, Kevin I Norton
PURPOSE: With knowledge of an individual's critical power (CP) and W' the SKIBA 2 model provides a framework with which to track W' balance during intermittent high intensity work bouts. There are fears the time constant controlling the recovery rate of W' (τW') may require refinement to enable effective use in an elite population. METHODS: Four elite endurance cyclists completed an array of intermittent exercise protocols to volitional exhaustion. Each protocol lasted approximately 3...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29033335/alpha-band-activity-reveals-spontaneous-representations-of-spatial-position-in-visual-working-memory
#7
Joshua J Foster, Emma M Bsales, Russell J Jaffe, Edward Awh
An emerging view suggests that spatial position is an integral component of working memory (WM), such that non-spatial features are bound to locations regardless of whether space is relevant [1, 2]. For instance, past work has shown that stimulus position is spontaneously remembered when non-spatial features are stored. Item recognition is enhanced when memoranda appear at the same location where they were encoded [3-5], and accessing non-spatial information elicits shifts of spatial attention to the original position of the stimulus [6, 7]...
October 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29032399/evidence-of-extracellular-vesicles-biogenesis-and-release-in-mouse-embryonic-stem-cells
#8
Lilian Cruz, Jenny Andrea Arevalo Romero, Mariana Brandão Prado, Tiago G Santos, Marilene Hohmuth Lopes
Extracellular vesicles (EVs) released by mouse embryonic stem cells (mESCs) are considered a source of bioactive molecules that modulate their microenvironment by acting on intercellular communication. Either intracellular endosomal machinery or their derived EVs have been considered a relevant system of signal circuits processing. Herein, we show that these features are found in mESCs. Ultrastructural analysis revealed structures and organelles of the endosomal system such as coated pits and endocytosis-related vesicles, prominent rough endoplasmic reticulum and Golgi apparatus, and multivesicular bodies (MVBs) containing either few or many intraluminal vesicles (ILVs) that could be released as exosomes to extracellular milieu...
October 14, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29032184/exploring-young-adult-perspectives-on-the-use-of-gamification-and-social-media-in-a-smartphone-platform-for-improving-vegetable-intake
#9
Monica Marina Nour, Anika Saiyara Rouf, Margaret Allman-Farinelli
Young adults are the poorest consumers of vegetables. Social media and smartphones are frequently used by this demographic and could serve as an engaging medium for nutrition promotion. Five focus groups were conducted to capture participants' perceptions of a theory-based gamified self-monitoring app for improving vegetable intake of young adults. Ranking activities were used to gather feedback on preferences for social media posts. Data arising from group discussion were analysed using NVivo software using a deductive approach to group common ideas into themes...
October 11, 2017: Appetite
https://www.readbyqxmd.com/read/29031984/analysis-of-carotid-artery-transverse-sections-in-long-ultrasound-video-sequences
#10
Kamil Říha, Martin Zukal, Franz Hlawatsch
Examination of the common carotid artery (CCA) based on an ultrasound video sequence is an effective method for detecting cardiovascular diseases. Here, we propose a video processing method for the automated geometric analysis of CCA transverse sections. By explicitly compensating the parasitic phenomena of global movement and feature drift, our method enables a reliable and accurate estimation of the movement of the arterial wall based on ultrasound sequences of arbitrary length and in situations where state-of-the-art methods fail or are very inaccurate...
October 11, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29030055/the-heart-of-pd-lewy-body-diseases-as-neurocardiologic-disorders
#11
David S Goldstein, Yehonatan Sharabi
This review provides an update about cardiac sympathetic denervation in Lewy body diseases. The family of Lewy body diseases includes Parkinson's disease (PD), pure autonomic failure (PAF), and dementia with Lewy bodies (DLB). All three feature intra-neuronal cytoplasmic deposits of the protein, alpha-synuclein. Multiple system atrophy (MSA), the parkinsonian form of which can be difficult to distinguish from PD with orthostatic hypotension, involves glial cytoplasmic inclusions that contain alpha-synuclein...
October 10, 2017: Brain Research
https://www.readbyqxmd.com/read/29029139/quantitative-deformation-analysis-differentiates-ischaemic-and-non-ischaemic-cardiomyopathy-sub-group-analysis-of-the-vindicate-trial
#12
James R J Foley, Peter P Swoboda, Graham J Fent, Pankaj Garg, Adam K McDiarmid, David P Ripley, Bara Erhayiem, Tarique Al Musa, Laura E Dobson, Sven Plein, Klaus K Witte, John P Greenwood
Aims: To test the hypothesis that patients with ischaemic cardiomyopathy (ICM) and non-ischaemic cardiomyopathy (NICM) have different torsion and strain parameters, and compare to healthy, age-matched controls. VINDICATE investigated efficacy of high-dose vitamin D on patients with heart failure (HF) secondary to left ventricular (LV) systolic dysfunction of any aetiology. It is important to differentiate ICM and NICM as treatment and prognosis varies significantly. Cardiovascular magnetic resonance (CMR) reliably determines aetiology of HF and tissue tagging techniques are recognized as the reference standard measures of strain and torsion...
October 3, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29029074/multimodality-imaging-evaluation-of-chagas-disease-an-expert-consensus-of-brazilian-cardiovascular-imaging-department-dic-and-the-european-association-of-cardiovascular-imaging-eacvi
#13
Maria Carmo P Nunes, Luigi Paolo Badano, J Antonio Marin-Neto, Thor Edvardsen, Covadonga Fernández-Golfín, Chiara Bucciarelli-Ducci, Bogdan A Popescu, Richard Underwood, Gilbert Habib, Jose Luis Zamorano, Roberto Magalhães Saraiva, Ester Cerdeira Sabino, Fernando A Botoni, Márcia Melo Barbosa, Marcio Vinicius L Barros, Eduardo Falqueto, Marcus Vinicius Simões, André Schmidt, Carlos Eduardo Rochitte, Manoel Otávio Costa Rocha, Antonio Luiz Pinho Ribeiro, Patrizio Lancellotti
Aims: To develop a document by Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI) to review and summarize the most recent evidences about the non-invasive assessment of patients with Chagas disease, with the intent to set up a framework for standardized cardiovascular imaging to assess cardiovascular morphologic and functional disturbances, as well as to guide the subsequent process of clinical decision-making. Methods and results: Chagas disease remains one of the most prevalent infectious diseases in Latin America, and has become a health problem in non-endemic countries...
September 25, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29028398/a-computer-model-of-comprehensive-modeling-of-the-laser-time-of-flight-analyzer
#14
Alexander V Karpov, Alexander A Sysoev
This article offers a new approach to computer modeling of time-of-flight analyzers of mass spectrometers. The main feature of the model is comprehensive tracking of the processes from the laser plasma generation until the final stage, on which the isotopic or elemental composition is determined for the analyzed solid sample. Apart from usual models based on SIMION-8 3D or similar software, this article proposes fundamentally new modeling stages. These stages are (1) generation and spread of laser plasma, (2) formation of the ion packages, (3) ion detection, and (4) formation and processing of the analytical signals...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29028265/stereogene-rapid-estimation-of-genome-wide-correlation-of-continuous-or-interval-feature-data
#15
Elena D Stavrovskaya, Tejasvi Niranjan, Elana J Fertig, Sarah J Wheelan, Alexander V Favorov, Andrey A Mironov
Motivation: Genomics features with similar genome-wide distributions are generally hypothesized to be functionally related, for example, colocalization of histones and transcription start sites indicate chromatin regulation of transcription factor activity. Therefore, statistical algorithms to perform spatial, genome-wide correlation among genomic features are required. Results: Here, we propose a method, StereoGene, that rapidly estimates genome-wide correlation among pairs of genomic features...
October 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29023595/actinide-bioimaging-in-tissues-comparison-of-emulsion-and-solid-track-autoradiography-techniques-with-the-iqid-camera
#16
Stephanie Lamart, Brian W Miller, Anne Van der Meeren, Anissa Tazrart, Jaime F Angulo, Nina M Griffiths
This work presents a comparison of three autoradiography techniques for imaging biological samples contaminated with actinides: emulsion-based, plastic-based autoradiography and a quantitative digital technique, the iQID camera, based on the numerical analysis of light from a scintillator screen. In radiation toxicology it has been important to develop means of imaging actinide distribution in tissues as these radionuclides may be heterogeneously distributed within and between tissues after internal contamination...
2017: PloS One
https://www.readbyqxmd.com/read/29023094/high-speed-atomic-force-microscopy-visualization-of-the-dynamics-of-the-multienzyme-fatty-acid-synthase
#17
Friederike M C Benning, Yusuke Sakiyama, Adam Mazur, Habib S T Bukhari, Roderick Y H Lim, Timm Maier
Multienzymes, such as the protein metazoan fatty acid synthase (FAS), are giant and highly dynamic molecular machines for critical biosynthetic processes. The molecular architecture of FAS was elucidated by static high-resolution crystallographic analysis, while electron microscopy revealed large-scale conformational variability in FAS with some correlation to functional states in catalysis. However, little is known about time scales of conformational dynamics, the trajectory of motions in individual FAS molecules and the extent of coupling between catalysis and structural changes...
October 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/29021341/acquisition-of-cell-migration-defines-nk-cell-differentiation-from-hematopoietic-stem-cell-precursors
#18
Barclay J Lee, Emily M Mace
Human natural killer (NK) cells are generated from CD34(+) precursors and can be differentiated in vitro by co-culture with developmentally supportive stromal cells. We have previously described the acquisition of cell migration as a feature of NK cell terminal maturation in this system. Here, we perform continuous long-term imaging and tracking of NK cell progenitors undergoing in vitro differentiation. We demonstrate that NK cell precursors can be tracked over long time periods on the order of weeks by utilizing phase-contrast microscopy, and show that these cells acquire increasing motility as they mature...
October 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29021117/there-is-an-app-for-that-or-is-there-a-content-analysis-of-publicly-available-smartphone-apps-for-managing-alcohol-use
#19
Bettina B Hoeppner, Melissa R Schick, Lourah M Kelly, Susanne S Hoeppner, Brandon Bergman, John F Kelly
INTRODUCTION: Smartphone apps are emerging as a promising tool to support recovery from and prevention of problematic alcohol use, yet it is unclear what type of apps are currently available in the public domain, and to what degree these apps use interactive tailoring or other dynamic features to meet users' specific needs. METHODS: We conducted a content analysis of Android apps for managing drinking available on Google Play (n=266), downloaded between November 21, 2014 and June 25, 2015...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29017452/whole-genome-sequencing-for-the-molecular-characterization-of-carbapenem-resistant-klebsiella-pneumoniae-strains-isolated-at-the-italian-asst-fatebenefratelli-sacco-hospital-2012-2014
#20
Sara Giordana Rimoldi, Bernardina Gentile, Cristina Pagani, Annamaria Di Gregorio, Anna Anselmo, Anna Maria Palozzi, Antonella Fortunato, Valentina Pittiglio, Anna Lisa Ridolfo, Maria Rita Gismondo, Giuliano Rizzardini, Florigio Lista
BACKGROUND: The emergence of carbapenem-resistant Klebsiella pneumoniae strains is threatening antimicrobial treatment. METHODS: Sixty-eight carbapenemase-producing K. pneumoniae strains isolated at Luigi Sacco University Hospital-ASST Fatebenefratelli Sacco (Milan, Italy) between 2012 and 2014 were characterised microbiologically and molecularly. They were tested for drug susceptibility and carbapenemase phenotypes, investigated by means of repetitive extra-genic palindromic polymerase chain reaction (REP-PCR), and fully sequenced by means of next-generation sequencing for the in silico analysis of multi-locus sequence typing (MLST), their resistome, virulome and plasmid content, and their core single nucleotide polymorphism (SNP) genotypes...
October 10, 2017: BMC Infectious Diseases
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