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Tissue Tracking

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https://www.readbyqxmd.com/read/28654584/a-novel-noncontact-diffuse-correlation-spectroscopy-device-for-assessing-blood-flow-in-mastectomy-skin-flaps-a-prospective-study-in-patients-undergoing-prosthesis-based-reconstruction
#1
Nneamaka B Agochukwu, Chong Huang, Mingjun Zhao, Ahmed A Bahrani, Li Chen, Patrick McGrath, Guoqiang Yu, Lesley Wong
A new advanced technology, noncontact diffuse correlation spectroscopy, has been recently developed for the measurement of tissue blood flow through analyzing the motions of red blood cells in deep tissues. This technology is portable, inexpensive, and noninvasive, and can measure up to 1.5-cm tissue depth. In this prospective study, the authors aimed to explore the use of this novel device in the prediction of mastectomy skin flap necrosis. The noncontact diffuse correlation spectroscopy device was used to measure mastectomy skin flap flow in patients undergoing mastectomy and immediate implant-based breast reconstruction before and immediately after mastectomy, and after placement of the prosthesis...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28651855/assessment-of-pose-repeatability-and-specimen-repositioning-of-a-robotic-joint-testing-platform
#2
H El Daou, B Lord, A Amis, F Rodriguez Y Baena
This paper describes the quantitative assessment of a robotic testing platform, consisting of an industrial robot and a universal force-moment sensor, via the design of fixtures used to hold the tibia and femur of cadaveric knees. This platform was used to study the contributions of different soft tissues and the ability of implants and reconstruction surgeries to restore normal joint functions, in previously published literature. To compare different conditions of human joints, it is essential to reposition specimens with high precision after they have been removed for a surgical procedure...
June 23, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28650431/illuminating-vital-surface-molecules-of-symbionts-in-health-and-disease
#3
Jason E Hudak, David Alvarez, Ashwin Skelly, Ulrich H von Andrian, Dennis L Kasper
The immunomodulatory surface molecules of commensal and pathogenic bacteria are critical to microorganisms' survival and the host's response(1,2). Recent studies have highlighted the unique and important responses elicited by commensal-derived surface macromolecules(3-5). However, the technology available to track these molecules in host cells and tissues remains primitive. We report, here, an interdisciplinary approach that uses metabolic labelling combined with bioorthogonal click chemistry (that is, reactions performed in living organisms)(6) to specifically tag up to three prominent surface immunomodulatory macromolecules-peptidoglycan, lipopolysaccharide and capsular polysaccharide-either simultaneously or individually in live anaerobic commensal bacteria...
June 26, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28648418/longitudinal-ventricular-systolic-dysfunction-in-patients-with-very-severe-obstructive-sleep-apnea-a-case-control-study-using-speckle-tracking-imaging
#4
Mithun Jacob Varghese, Gautam Sharma, Garima Shukla, Sandeep Seth, Sundeep Mishra, Anupama Gupta, Vinay Kumar Bahl
OBJECTIVE: Obstructive sleep apnea (OSA) is a prevalent condition that is increasingly recognized to be associated with cardiovascular disease. We aimed to investigate the subclinical systolic ventricular dysfunction of patients with OSA using novel speckle tracking echocardiographic (STE) techniques. METHODS: This study included 31 patients of polysomnography proven very severe OSA [Apnea Hypopnea Index(AHI) >40] and an equal number of matched population with no OSA as controls...
May 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28648029/-effects-of-overexpression-of-human-tissue-inhibitor-of-metalloproteinase-1-on-the-inflammatory-response-in-rats-with-myocardial-infarction-and-related-mechanisms
#5
L L Zhao, Y Q Song, Y Zhang, Y Shi, M Ren, S Liu, Y M Mao
Objective: To observe the effects of recombinant adenovirus with human tissue inhibitor of metalloproteinase-1(Ad-hTIMP-1) on the inflammatory response in rats with myocardial infarction (MI) and explore the related mechanisms. Methods: The male Wistar rats were randomly divided into sham-operated group, saline group, Ad-Track group and Ad-hTIMP-1 group according to the random number table (n=8 each group). MI was induced by ligation of the left anterior descending coronary artery and MI rats were injected with saline, Ad-Track and Ad-hTIMP-1, respectively...
June 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28647883/casper-computer-aided-segmentation-of-imperceptible-motion-a-learning-based-tracking-of-an-invisible-needle-in-ultrasound
#6
Parmida Beigi, Robert Rohling, Septimiu E Salcudean, Gary C Ng
PURPOSE: This paper presents a new micro-motion-based approach to track a needle in ultrasound images captured by a handheld transducer. METHODS: We propose a novel learning-based framework to track a handheld needle by detecting microscale variations of motion dynamics over time. The current state of the art on using motion analysis for needle detection uses absolute motion and hence work well only when the transducer is static. We have introduced and evaluated novel spatiotemporal and spectral features, obtained from the phase image, in a self-supervised tracking framework to improve the detection accuracy in the subsequent frames using incremental training...
June 24, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28647817/molecular-characterization-of-the-cd79a-and-cd79b-and-its-role-against-aeromonas-hydrophila-infection-in-chinese-sucker-myxocyprinus-asiaticus
#7
Huan Li, Yujin Li, Xiaoping Zhang, Yafeng Wang, Wufeng Zhang, Xia Wu, Zhijian Wang
CD79a and CD79b heterodimers are the important signaling components of B cell receptor (BCR) complex which plays a crucial role in B cell development and antibody production. In the present study, CD79a and CD79b homologues from Chinese sucker (Myxocyprinus asiaticus), namely MaCD79a and MaCD79b, were identified and their expression at early developmental stages and under constitutive and stimulated conditions were investigated. The cDNA sequences for MaCD79a and MaCD79b contained open reading frame of 678 and 636 bp in length for 225 and 211 amino acid residues, respectively...
June 25, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28646909/the-morphological-regeneration-and-functional-restoration-of-bladder-defects-by-a-novel-scaffold-and-adipose-derived-stem-cells-in-a-rat-augmentation-model
#8
Qiong Wang, Dong-Dong Xiao, Hao Yan, Yang Zhao, Shi Fu, Juan Zhou, Zhong Wang, Zhe Zhou, Ming Zhang, Mu-Jun Lu
BACKGROUND: Due to the multilineage differentiation ability and paracrine role of adipose-derived stem cells (ASCs) for bladder defect repair, various scaffolds have been applied in combination with ASCs to promote bladder regeneration and restore bladder function. However, the low survival rate of ASCs and the difficulty of promoting bladder functional recovery are still unsolved. To explore these problems, we investigated the feasibility of a novel scaffold seeded with ASCs in a rat model of bladder augmentation...
June 24, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28646184/homing-of-cultured-endothelial-progenitor-cells-and-their-effect-on-traumatic-brain-injury-in-rat-model
#9
Xin-Bin Guo, Xin Deng, Ying Wei
Transplanted endothelial progenitor cells (EPCs) may play an important role in reestablishing the endothelial integrity of the vessels after brain injury, and contribute to neurogenesis. We, therefore, tested the homing of ex vivo cultured peripheral blood-derived EPCs and their effect on injured brain tissue after intravenous administration. To track the homing of implanted EPCs in injured brain tissues, EPCs were labeled with DAPI and BrdU in vitro before transplantation. EPCs were transplanted into the host animal through peripheral administration through the femoral vein, and homing of EPCs was evaluated...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645895/multiparity-improves-outcomes-after-cerebral-ischemia-in-female-mice-despite-features-of-increased-metabovascular-risk
#10
Rodney M Ritzel, Anita R Patel, Monica Spychala, Rajkumar Verma, Joshua Crapser, Edward C Koellhoffer, Anna Schrecengost, Evan R Jellison, Liang Zhu, Venugopal Reddy Venna, Louise D McCullough
Females show a varying degree of ischemic sensitivity throughout their lifespan, which is not fully explained by hormonal or genetic factors. Epidemiological data suggest that sex-specific life experiences such as pregnancy increase stroke risk. This work evaluated the role of parity on stroke outcome. Age-matched virgin (i.e., nulliparous) and multiparous mice were subjected to 60 min of reversible middle cerebral artery occlusion and evaluated for infarct volume, behavioral recovery, and inflammation. Using an established mating paradigm, fetal microchimeric cells present in maternal mice were also tracked after parturition and stroke...
June 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28645886/uterovaginal-anastomosis-for-cases-of-cryptomenorrhea-due-to-cervical-atresia-with-vaginal-aplasia-benefits-and-risks
#11
M A Zayed, R F Khalil, K A Elsetohy, A T Hashem, A A AbdAllah, A I Fathi
STUDY OBJECTIVE: The objective of this study is to assess short term benefits and risks of utero-vaginal anastomosis done for cases of cryptomenorrhea due to cervical atresia with vaginal aplasia. DESIGN: prospective study SETTING: Surgical operations were done between December 2013 and September 2015 at the department of Obstetrics and Gynecology, Cairo University Hospital. PARTICIPANTS: Five patients who had cryptomenorrhea due to cervical atresia associated with vaginal aplasia were included...
June 20, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28644188/surgical-techniques-for-total-knee-arthroplasty-measured-resection-gap-balancing-and-hybrid
#12
Neil P Sheth, Adeel Husain, Charles Lenwood Nelson
Total knee arthroplasty (TKA) is effective in managing end-stage degenerative joint disease. Achieving favorable clinical outcomes is predicated on proper implant alignment, sizing, and rotation as well as adequate soft-tissue balancing. Modern TKA implants are designed to address the fundamental needs of attaining stability in both flexion and extension and of optimizing patellar tracking. Measured resection and gap balancing are the two different techniques used to implant the TKA components used today. Both techniques have been validated as durable and successful, and each has unique advantages and disadvantages...
July 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28642098/quantifying-left-atrial-structure-and-function-using-single-plane-tissue-tracking-cardiac-magnetic-resonance
#13
Susumu Tao, Luisa A Ciuffo, Joao A C Lima, Katherine C Wu, Hiroshi Ashikaga
PURPOSE: Left atrial (LA) structure and function are important markers of adverse cardiovascular outcomes. Tissue-tracking cardiovascular magnetic resonance (CMR) accurately quantifies LA volume, strain, and strain rate based on biplane long-axis imaging. We aimed to assess the accuracy of the LA indices quantification from single-plane tissue-tracking CMR. METHODS: We included 162 patients (mean age 56±15, male 70%) from a prospective cohort study whose cine CMR images in sinus rhythm were available in both four-chamber and two-chamber views...
June 19, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28641018/three-dimensional-imaging-of-transparent-tissues-via-metal-nanoparticle-labeling
#14
Abdullah Muhammad Syed, Shrey Sindhwani, Stefan Wilhelm, Benjamin R Kingston, Dennis S W Lee, Jennifer L Gommerman, Warren C W Chan
Chemical probes are key components of the bioimaging toolbox as they label biomolecules in cells and tissues. The new challenge in bioimaging is to design chemical probes for 3-Dimensional (3D) tissue imaging. Here, we discovered that the scattering of metal nanoparticles can provide imaging contrast in intact tissues in 3D. The nanoparticles can act as a template for chemically growing a metal layer to further enhance the scattering signal. The use of chemically-grown nanoparticles in whole tissues can amplify the scattering to produce a 1...
June 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28638107/tracking-protein-function-with-sodium-multi-quantum%C3%A2-spectroscopy-in-a-3d-tissue-culture-based-on-microcavity-arrays
#15
Andreas Neubauer, Cordula Nies, Victor D Schepkin, Ruomin Hu, Matthias Malzacher, Jorge Chacón-Caldera, David Thiele, Eric Gottwald, Lothar R Schad
The aim of this study was to observe the effects of strophanthin induced inhibition of the Na-/K-ATPase in liver cells using a magnetic resonance (MR) compatible bioreactor. A microcavity array with a high density three-dimensional cell culture served as a functional magnetic resonance imaging (MRI) phantom for sodium multi quantum (MQ) spectroscopy. Direct contrast enhanced (DCE) MRI revealed the homogenous distribution of biochemical substances inside the bioreactor. NMR experiments using advanced bioreactors have advantages with respect to having full control over a variety of physiological parameters such as temperature, gas composition and fluid flow...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28636515/a-brief-period-of-intensive-cardiac-rehabilitation-improves-global-longitudinal-strain-and-diastolic-function-after-a-first-uncomplicated-myocardial-infarction
#16
Gabriella Malfatto, Miriam Revera, Giovanna Branzi, Francesca Ciambellotti, Alessia Giglio, Simonetta Blengino, Matteo Oldani, Camilla Facchini, Gianfranco Parati, Mario Facchini
Objectives In patients with abnormal left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI), cardiac rehabilitation with physical training prevents cardiac remodelling. To define the role of rehabilitation in the recovery of ventricular function in less severe cases, we studied its effects on more refined indexes of left ventricular function in uncomplicated, low-risk patients. Methods and results Fifty-five patients underwent percutaneous coronary revascularization after uncomplicated first AMI...
March 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28634819/establishment-of-a-tagged-variant-of-lgr4-receptor-suitable-for-functional-and-expression-studies-in-the-mouse
#17
Vitezslav Kriz, Michaela Krausova, Petra Buresova, Jan Dobes, Dusan Hrckulak, Olga Babosova, Jiri Svec, Vladimir Korinek
Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4) is produced in a broad spectrum of mouse embryonic and adult tissues and its deficiency results in embryonal or perinatal lethality. The LGR4 function was mainly related to its potentiation of canonical Wnt signaling; however, several recent studies associate LGR4 with additional signaling pathways. To obtain a suitable tool for studying the signaling properties of Lgr4, we generated a tagged variant of the Lgr4 receptor using gene targeting in the mouse oocyte...
June 20, 2017: Transgenic Research
https://www.readbyqxmd.com/read/28634220/tidal-changes-on-ct-and-progression-of-ards
#18
Maurizio Cereda, Yi Xin, Hooman Hamedani, Giacomo Bellani, Stephen Kadlecek, Justin Clapp, Luca Guerra, Natalie Meeder, Jennia Rajaei, Nicholas J Tustison, James C Gee, Brian P Kavanagh, Rahim R Rizi
BACKGROUND: Uncertain prediction of outcome in acute respiratory distress syndrome (ARDS) impedes individual patient management and clinical trial design. OBJECTIVES: To develop a radiological metric of injurious inflation derived from matched inspiratory and expiratory CT scans, calibrate it in a model of experimental lung injury, and test it in patients with ARDS. METHODS: 73 anaesthetised rats (acid aspiration model) were ventilated (protective or non-protective) for up to 4 hours to generate a spectrum of lung injury...
June 20, 2017: Thorax
https://www.readbyqxmd.com/read/28630755/advances-in-hip-arthroplasty-surgery-what-is-justified
#19
Luigi Zagra
Total hip arthroplasty (THA) surgery has shown dramatic changes in terms of increased number of procedures and of technical development in recent years. It has been described as "the operation of the 20(th) century" for the excellent results, the high satisfaction of the patients and the improvement of the quality of life.A lot of variations have been introduced over the last few decades in THA especially in terms of indications (both in younger and older patients), techniques and devices (approaches, tissue preservation, biomaterials and industrial finishing), per-operative management (blood loss and pain control) and post-operative protocols (the so called "fast track" surgery)...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28629031/near-infrared-persistent-luminescence-phosphors-znga-2-o-4-cr-3-as-an-accurately-tracker-to-photothermal-therapy-in-vivo-for-visual-treatment
#20
Hongbin Chen, Bin Zheng, Chao Liang, Li Zhao, Ying Zhang, Huizhuo Pan, Wanying Ji, Xiaoqun Gong, Hanjie Wang, Jin Chang
The photothermal therapy agents induced by 808 nm near infrared light laser have good potential for photothermal therapy (PTT) in vivo, with the advantages of harmless treatment, minimally invasion, high efficiency and deep tissue penetration. For the traditional photothermal therapy agents, however, it was impossible to track them in vivo because of the low signal-to-noise ratio, so we cannot conduct the extra near infrared light laser to radiate tumors sites accurately. Herein, we introduce a new complex: indocyanine green (ICG), near-infrared persistent luminescence (PL) phosphors ZnGa2O4:Cr(3+) (ZGC) and mesoporous silica nanoparticles (MSNs) (ICG@mZGC nanoparticles) were assembled for long-lasting optical imaging to guide PTT...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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