keyword
MENU ▼
Read by QxMD icon Read
search

Tissue Characterization

keyword
https://www.readbyqxmd.com/read/29793157/energy-dissipation-in-quasi-linear-viscoelastic-tissues-cells-and-extracellular-matrix
#1
Behzad Babaei, A J Velasquez-Mao, Kenneth M Pryse, William B McConnaughey, Elliot L Elson, Guy M Genin
Characterizing how a tissue's constituents give rise to its viscoelasticity is important for uncovering how hidden timescales underlie multiscale biomechanics. These constituents are viscoelastic in nature, and their mechanics must typically be assessed from the uniaxial behavior of a tissue. Confounding the challenge is that tissue viscoelasticity is typically associated with nonlinear elastic responses. Here, we experimentally assessed how fibroblasts and extracellular matrix (ECM) within engineered tissue constructs give rise to the nonlinear viscoelastic responses of a tissue...
May 21, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29793152/identification-of-seven-polyamine-oxidase-genes-in-tomato-solanum-lycopersicum-l-and-their-expression-profiles-under-physiological-and-various-stress-conditions
#2
Yanwei Hao, Binbin Huang, Dongyu Jia, Taylor Mann, Xinyi Jiang, Yuxing Qiu, Masaru Niitsu, Thomas Berberich, Tomonobu Kusano, Taibo Liu
Polyamines (PAs) are implicated in developmental processes and stress responses of plants. Polyamine oxidases (PAOs), flavin adenine dinucleotide-dependent enzymes that function in PA catabolism, play a critical role. Even though PAO gene families of Arabidopsis and rice have been intensely characterized and their expression in response to developmental and environmental changes has been investigated, little is known about PAOs in tomato (Solanum lycopersicum). We found seven PAO genes in S. lycopersicum and named them SlPAO1∼7...
May 15, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29793112/3d-printed-membrane-as-an-alternative-to-amniotic-membrane-for-ocular-surface-conjunctival-defect-reconstruction-an-in-vitro-in-vivo-study
#3
Shima Dehghani, Morteza Rasoulianboroujeni, Hamed Ghasemi, Saeed Heidari Keshel, Zohreh Nozarian, Mohammad Naser Hashemian, Mehran Zarei-Ghanavati, Golshan Latifi, Reza Ghaffari, Zhanfeng Cui, Hua Ye, Lobat Tayebi
BACKGROUND: The aim of this study was to evaluate the surgical handling and clinical applicability of a specific 3D-printed membrane design fabricated using a gelatin, elastin and sodium hyaluronate blend for conjunctival reconstruction and compare it with amniotic membrane (AM), which is normally used in such surgeries. METHODS: 3D printing technique was employed to fabricate the membrane based on gradient design. Prior to printing, rheometry was employed to optimize the ink composition...
May 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29793106/microplastics-in-mussels-sampled-from-coastal-waters-and-supermarkets-in-the-united-kingdom
#4
Jiana Li, Christopher Green, Alan Reynolds, Huahong Shi, Jeanette M Rotchell
Global contamination of the marine environment by plastic has led to the discovery of microplastics in a range of marine species, including those for human consumption. In this study, the presence of microplastics and other anthropogenic debris in seawater and mussels (Mytilus edulis) from coastal waters of the U.K., as well as supermarket sources, was investigated. These were detected in all samples from all sites with spatial differences observed. Seawater samples taken from 6 locations (in triplicates) displayed 3...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29793090/anti-haemostatic-compounds-from-the-vampire-snail-cumia-reticulata-molecular-cloning-and-in-silico-structure-function-analysis
#5
Maria Vittoria Modica, Jonathan Reinoso Sánchez, Andrea Pasquadibisceglie, Marco Oliverio, Paolo Mariottini, Manuela Cervelli
Blood-feeding animals are known for their ability to produce bioactive compounds to impair haemostasis and suppress pain perception in the host. These compounds are extremely appealing for pharmacological development since they are generally very effective and specific for their molecular target. A preliminary RNA-Seq based characterization of the secretion from salivary and mid-oesophageal tissues of the vampire snail Cumia reticulata, revealed a complex mixture of feeding-related transcripts with potential anaesthetic and anticoagulant action...
May 16, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29793057/ellagic-acid-protects-from-myelin-associated-sphingolipid-loss-in-experimental-autoimmune-encephalomyelitis
#6
Rebeca Busto, Jorge Serna, Aránzazu Perianes-Cachero, Rocío Quintana-Portillo, David García-Seisdedos, Alberto Canfrán-Duque, Carlos L Paino, Milagros Lerma, María E Casado, Antonia Martín-Hidalgo, Eduardo Arilla-Ferreiro, Miguel A Lasunción, Óscar Pastor
Experimental autoimmune encephalomyelitis (EAE), the most common model for multiple sclerosis, is characterized by inflammatory cell infiltration into the central nervous system and demyelination. Previous studies have demonstrated that administration of some polyphenols may reduce the neurological alterations of EAE. In this work, we show that ellagic acid, a polyphenolic compound, is beneficial in EAE, most likely through stimulation of ceramide biosynthesis within the brain. EAE was induced in Lewis rats by injection of guinea-pig spinal cord tissue along with Freund's complete adjuvant containing Mycobacterium tuberculosis...
May 21, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29792891/pcl-eug-scaffolds-with-tunable-stiffness-can-regulate-macrophage-secretion-behavior
#7
REVIEW
Y Z B Xue, Yiming Niu, B Tang, C M Wang
Osteoarthritis (OA) is a prevalent joint disorder worldwide. Recent studies suggested that macrophages play an important role in the progression of OA. However, the detailed pathology related to macrophages is still ambiguous, especially those related to mechanotransduction. In this study, PCL/EUG composite scaffolds were first fabricated by electrospinning. The stiffness of as-fabricated scaffolds was controlled by adjusting the PCL-versus-EUG ratio. The mechanical properties, structural characterics and chemical composition of the scaffolds were investigated using various materials characterization techniques...
May 21, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29792210/quantitative-cardiovascular-magnetic-resonance-extracellular-volume-native-t1-and-18f-fdg-pet-cmr-imaging-in-patients-after-revascularized-myocardial-infarction-and-association-with-markers-of-myocardial-damage-and-systemic-inflammation
#8
Karl P Kunze, Ralf J Dirschinger, Hans Kossmann, Franziska Hanus, Tareq Ibrahim, Karl-Ludwig Laugwitz, Markus Schwaiger, Christoph Rischpler, Stephan G Nekolla
BACKGROUND: Characterization of tissue integrity and inflammatory processes after acute myocardial infarction (AMI) using non-invasive imaging is predictive of patient outcome. Quantitative cardiovascular magnetic resonance (CMR) techniques such as native T1 and extracellular volume (ECV) mapping as well as 18 F-FDG positron emission tomography (PET) imaging targeting inflammatory cell populations are gaining acceptance, but are often applied without assessing their quantitative potential...
May 24, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29792034/soft-hydrogel-zwitterionic-coatings-minimize-fibroblast-and-macrophage-adhesion-on-polyimide-substrates
#9
Dusana Trelova, Alice Rita Salgarella, Leonardo Ricotti, Guido Giudetti, Annarita Cutrone, Petra Sramkova, Anna Zahoranova, Dusan Chorvat, Daniel Hasko, Claudio Canale, Silvestro Micera, Juraj Kronek, Arianna Menciassi, Igor Lacik
Minimizing the foreign body reaction to polyimide-based implanted devices has a pivotal role for several biomedical applications. In this work we propose materials exhibiting non-biofouling properties and a Young's modulus reflecting the one of soft human tissues. We describe the synthesis, characterization and in vitro validation of poly(carboxybetaine) hydrogel coatings covalently attached to polyimide substrates via a photolabile 4-azidophenyl group, incorporated in poly(carboxybetaine) chains at two concentrations of 1...
May 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29791746/molecular-and-cellular-characterization-of-nachr-subtypes-in-the-arcuate-nucleus-of-the-mouse-hypothalamus
#10
Cali A Calarco, Zhiying Li, Seth R Taylor, Somin Lee, Wenliang Zhou, Jeffrey M Friedman, Yann S Mineur, Cecilia Gotti, Marina R Picciotto
Nicotine, acting through nicotinic acetylcholine receptors (nAChRs), increases the firing rate of both orexigenic agouti-related peptide (AgRP) and anorexigenic pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC), yet nicotine and other nAChR agonists decrease food intake in mice. Viral-mediated knockdown of β4 nAChR subunit in all neuronal cell types in the ARC prevents the nicotinic agonist cytisine from decreasing food intake, but it is not known whether the β4 subunit is selectively expressed in anorexogenic neurons or how other nAChR subtypes are distributed in this nucleus...
May 23, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29791720/c-4-photosynthesis-and-transition-of-kranz-anatomy-in-cotyledons-and-leaves-of-tetraena-simplex
#11
Riyadh Muhaidat, Athena D McKown, Mazhar Al Zoubi, Zakariya Bani Domi, Osama Otoum
PREMISE OF THE STUDY: Tetraena simplex is an independently evolved C4 species in the Zygophylloideae (Zygophyllaceae) and a characteristic forb of saline flats in hot and sandy desert habitats. During early ontogeny, the species had a morphological shift from planar cotyledons (dorsiventral symmetry) to terete, succulent leaves (radial symmetry). We tested whether this shift had a corresponding change in internal Kranz anatomy and tissue patterning. METHODS: For a comprehensive characterization of C4 photosynthesis across early ontogeny in T...
May 23, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29791497/xenin-is-a-novel-anorexigen-in-goldfish-carassius-auratus
#12
Brent Kerbel, Kimberly Badal, Lakshminarasimhan Sundarrajan, Ayelen Blanco, Suraj Unniappan
Xenin, a highly conserved 25 amino acid peptide cleaved from the N-terminus of the coatomer protein alpha (COPA), is emerging as a food intake regulator in mammals and birds. To date, no research has been conducted on xenin biology in fish. This study aims to identify the copa mRNA encoding xenin in goldfish (Carassius auratus) as a model, to elucidate its regulation by feeding, and to describe the role of xenin on appetite. First, a partial sequence of copa cDNA, a region encoding xenin, was identified from goldfish brain...
2018: PloS One
https://www.readbyqxmd.com/read/29791323/male-and-female-characteristics-of-facial-soft-tissue-thickness-in-different-orthodontic-malocclusions-evaluated-by-cephalometric-radiography
#13
Tatjana Perović, Zorica Blažej
BACKGROUND The facial profile is determined by the facial soft tissue thickness (FSTT) and dentoskeletal characteristics. The aim of this study was to compare male and female characteristics of FSTT in different orthodontic malocclusions using cephalometric radiography. MATERIAL AND METHODS One hundred and twenty lateral cephalometric radiography-derived cephalograms of adult male (n=47) and female (n=73) orthodontic patients, aged between 16-22 years were classified according to their dentoskeletal relationships as Class I (n=30), Class II Division 1 (n=30), Class II Division 2 (n=30), Class III (n=30)...
May 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29790972/isolation-and-biological-characterization-of-mesenchymal-stem-cells-from-goose-dermis
#14
Jingjing Wang, Xulun Wu, Yanjie Zheng, Hebao Wen, Hongda Ji, Yuhua Zhao, Weijun Guan
The skin is a natural target of stem cell research because of its large size and easy accessibility. Cutaneous mesenchymal stem cells have shown to be a promising source of various adult stem cell or progenitor cell populations, which provide an important source of stem cell-based investigation. Nowadays, much work has been done on dermal-derived mesenchymal stem cells (DMSCs) from humans, mice, sheep, and other mammals, but the literature on avian species has been rarely reported. As an animal model, the goose is an endemic species abounding in dermal tissues which is important in the global economy...
May 21, 2018: Poultry Science
https://www.readbyqxmd.com/read/29790959/peripheral-blood-gene-expression-reveals-an-inflammatory-transcriptomic-signature-in-friedreich-s-ataxia-patients
#15
Daniel Nachun, Fuying Gao, Charles Isaacs, Cassandra Strawser, Zhongan Yang, Deepika Dokuru, Victoria Van Berlo, Renee Sears, Jennifer Farmer, Susan Perlman, David R Lynch, Giovanni Coppola
Transcriptional changes in Friedreich's ataxia (FRDA), a rare and debilitating recessive Mendelian neurodegenerative disorder, have been studied in affected but inaccessible tissues - such as dorsal root ganglia, sensory neurons, and cerebellum - in animal models or small patient series. However, transcriptional changes induced by FRDA in peripheral blood, a readily accessible tissue, have not been characterized in a large sample. We used differential expression, association with disability stage, network analysis, and enrichment analysis to characterize the peripheral blood transcriptome and identify genes that were differentially expressed in FRDA patients (n = 418) compared to both heterozygous expansion carriers (n = 228) and controls (n = 93, 739 individuals in total), or were associated with disease progression, resulting in a disease signature for FRDA...
May 22, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29790801/development-and-characterization-of-polymeric-microparticle-of-poly-d-l-lactic-acid-loaded-with-holmium-acetylacetonate
#16
Mariangela de Burgos M de Azevedo, Vitor H S de Melo, Carlos Roberto J Soares, Douglas M Miyamoto, Ricardo A Katayama, Peterson L Squair, Caio H N Barros, Ljubica Tasic
Biodegradable polymers containing radioactive isotopes such as Holmium 166 (166 Ho) have potential applications as beta particle emitters in tumor tissues. It is also a gamma ray emitter, allowing nuclear imaging of any tissue to be acquired. It is frequently used in the form of complexes such as holmium acetylacetonate (HoAcAc), which may cause damages in tissues next to the targets cancer cells, as it is difficult to control its linkage or healthy tissues radiotherapy effects. Poly(D,L-lactic acid), PDLLA, was used to encapsulate holmium acetylacetonate (HoAcAc) using an emulsion solvent extraction/evaporation technique...
May 23, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29790662/pathogenic-characterization-of-porcine-reproductive-and-respiratory-syndrome-virus-of-indian-origin-in-experimentally-infected-piglets
#17
D Senthilkumar, K Rajukumar, A Sen, M Kumar, D Shrivastava, S Kalaiyarasu, S Gautam, F Singh, D D Kulkarni, V P Singh
Porcine reproductive and respiratory syndrome (PRRS) is an economically important transboundary viral disease of pigs confronting the swine industry worldwide. This study was aimed to assess the pathogenic potential of PRRS virus belonging to genotype 2 that emerged in India in 2013. Nine 6-week-old piglets were inoculated intranasally with 2 × 105.75  TCID50 /ml of PRRSV (Ind-297221/2013). Three piglets were kept as uninfected controls. Blood and nasal swabs were collected daily up to 7 days post-infection (dpi) and on alternate days subsequently...
May 23, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29790600/characterizing-the-tissue-dielectric-constant-of-skin-basal-cell-cancer-lesions
#18
H N Mayrovitz, S R Gildenberg, P Spagna, L Killpack, D A Altman
BACKGROUND: Measuring tissue dielectric constant (TDC) of cancer tissues to distinguish them from normal or non-cancerous tissues has been an active area of research that has targeted several different cancer types usually using in vitro specimens. The goal of this study was to determine if and to what extent TDC values measured in vivo at 300 MHz using a simple hand-held measuring device might differentiate between skin cancer lesions and non-cancerous skin. MATERIALS AND METHODS: Triplicate TDC measurements were made in 32 patients who were subsequently diagnosed with skin basal cell carcinoma (BCC) and in 14 patients subsequently diagnosed as having non-cancerous lesions...
May 23, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29790225/can-cardiovascular-mri-be-used-to-more-definitively-characterize-cardiac-masses-initially-identified-using-echocardiography
#19
Vikas K Rathi, Anna T Czajka, Diane V Thompson, Mark Doyle, Tarun Tewatia, June Yamrozik, Ronald B Williams, Robert W W Biederman
In diagnosing cardiac and paracardiac masses, cardiac MRI (CMR) has gained acceptance as the gold standard. CMR has been observed to be superior to echocardiography in characterizing soft-tissue structures and, specifically, in classifying cardiac masses. The aim of our study was to evaluate the association between mortality and cardiac or paracardiac masses initially identified by echocardiography (ECHO) and confirmed by CMR. Between January 2002 and August 2007, a total of 158 patients underwent both ECHO and CMR for the evaluation of cardiac masses that were equivocal or undefined by ECHO...
May 2018: Echocardiography
https://www.readbyqxmd.com/read/29790189/the-identification-of-a-novel-antibody-for-cd133-using-human-antibody-phage-display
#20
Paige M Glumac, Colleen L Forster, Hong Zhou, Paari Murugan, Shilpa Gupta, Aaron M LeBeau
BACKGROUND: The transmembrane glycoprotein CD133 is believed to be a marker of adult prostate stem cells and cancer stem/initiating cells. Investigating the role of CD133 in the normal biology of the prostate and in cancer is complicated by the lack of a sensitive and accurate antibody for its detection. Here, we describe the characterization of a unique antibody identified using human antibody phage display that can recognize CD133 in both formalin-fixed tissues and cell lines. METHODS: A human single-chain variable fragment (scFv) antibody phage display library possessing a diversity of 8 × 109 was screened against fully glycosylated recombinant CD133...
May 22, 2018: Prostate
keyword
keyword
78360
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"