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Cardiovascular MR

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https://www.readbyqxmd.com/read/27908279/co-existing-intracranial-and-extracranial-carotid-artery-atherosclerotic-plaques-and-recurrent-stroke-risk-a-three-dimensional-multicontrast-cardiovascular-magnetic-resonance-study
#1
Yilan Xu, Chun Yuan, Zechen Zhou, Le He, Donghua Mi, Rui Li, Yuanyuan Cui, Yilong Wang, Yongjun Wang, Gaifen Liu, Zhuozhao Zheng, Xihai Zhao
BACKGROUND: As a systemic disease, atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously which is defined as co-existing plaques. Previous studies demonstrated that co-existing atherosclerotic diseases are significantly associated with ischemic cerebrovascular events. The aim of this study was to investigate the characteristics of co-existing intracranial and extracranial carotid atherosclerotic plaques and their relationships with recurrent stroke by using 3D multi-contrast magnetic resonance (MR) vessel wall imaging...
December 2, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27908177/automatic-segmentation-of-right-ventricle-in-cardiac-cine-mr-images-using-a-saliency-analysis
#2
Angélica Atehortúa, Maria A Zuluaga, Juan D García, Eduardo Romero
PURPOSE: Accurate measurement of the right ventricle (RV) volume is important for the assessment of the ventricular function and a biomarker of the progression of any cardiovascular disease. However, the high RV variability makes difficult a proper delineation of the myocardium wall. This paper introduces a new automatic method for segmenting the RV volume from short axis cardiac magnetic resonance (MR) images by a salient analysis of temporal and spatial observations. METHODS: The RV volume estimation starts by localizing the heart as the region with the most coherent motion during the cardiac cycle...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27900641/cardiovascular-pet-mr-we-need-evidence-not-hype
#3
EDITORIAL
Afshin Farzaneh-Far, Raymond Y Kwong
Recent introduction of hybrid positron emission tomography/magnetic resonance (PET/MR) scanners has created excitement regarding potential applications in cardiovascular medicine. This has led to a number of optimistic assessments of its potential value in the nuclear cardiology literature, although most published data are still at the feasibility or pre-clinical level. Such excitement is understandable and provides "fuel" for generation of the necessary clinical validation studies, which will be required. Given the current scrutiny from payers and government agencies to reduce the costs of cardiac imaging, the responsibility for showing additive benefit lies on the shoulders of those advocating for new, more expensive technologies...
November 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27899396/twenty-year-outcome-after-mitral-repair-versus-replacement-for-severe-degenerative-mitral-regurgitation-analysis-of-a-large-prospective-multicenter-international-registry
#4
Siham Lazam, Jean-Louis Vanoverschelde, Christophe Tribouilloy, Francesco Grigioni, Rakesh M Suri, Jean-Francois Avierinos, Christophe de Meester, Andrea Barbieri, Dan Rusinaru, Antonio Russo, Agnès A Pasquet, Hector I Michelena, Marianne Huebner, Joseph Maalouf, Marie-Annick Clavel, Catherine Szymanski, Maurice E Enriquez-Sarano
BACKGROUND: -Mitral valve (MV) repair is preferred over replacement in clinical guidelines and is an important determinant of the indication for surgery in degenerative mitral regurgitation (MR). Yet, the level of evidence supporting current recommendations is low, and recent data cast doubts on its validity in the current era. Accordingly, the aim of the present study was to analyze very long-term outcome after MV repair and replacement for degenerative MR with a flail leaflet. METHODS: -MIDA is a multicenter registry enrolling patients with degenerative MR with a flail leaflet in 6 tertiary European and US centers...
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27895576/sleep-disturbances-among-older-adults-in-the-united-states-2002-2012-nationwide-inpatient-rates-predictors-and-outcomes
#5
Alyssa A Gamaldo, May A Beydoun, Hind A Beydoun, Hailun Liang, Rachel E Salas, Alan B Zonderman, Charlene E Gamaldo, Shaker M Eid
Objective/Background: We examined the rates, predictors, and outcomes [mortality risk (MR), length of stay (LOS), and total charges (TC)] of sleep disturbances in older hospitalized patients. Patients/Methods: Using the U.S. Nationwide Inpatient Sample database (2002-2012), older patients (≥60 years) were selected and rates of insomnia, obstructive sleep apnea (OSA) and other sleep disturbances (OSD) were estimated using ICD-9CM. TC, adjusted for inflation, was of primary interest, while MR and LOS were secondary outcomes...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27892889/the-impact-of-functional-vs-degenerative-mitral-regurgitation-on-clinical-outcomes-among-patients-undergoing-transcatheter-aortic-valve-implantation
#6
René Vollenbroich, Stefan Stortecky, Fabien Praz, Jonas Lanz, Anna Franzone, Katarzyna Zuk, Dik Heg, Marco Valgimigli, Crochan John O'Sullivan, Corinna Heinisch, Eva Roost, Peter Wenaweser, Stephan Windecker, Thomas Pilgrim
BACKGROUND: Among patients undergoing transcatheter aortic valve implantation (TAVI), concomitant mitral regurgitation (MR) has been associated with adverse prognosis. We aimed to assess long-term clinical outcomes according to MR etiology. METHODS: In a single-center registry of consecutive patients undergoing TAVI, we investigated the impact of functional (FMR) vs degenerative (DMR) MR on cardiovascular (CV) mortality throughout 2years of follow-up. RESULTS: Among 603 patients (mean age 82...
October 28, 2016: American Heart Journal
https://www.readbyqxmd.com/read/27876066/in-vivo-cardiovascular-magnetic-resonance-of-2d-vessel-wall-diffusion-anisotropy-in-carotid-arteries
#7
Peter Opriessnig, Harald Mangge, Rudolf Stollberger, Hannes Deutschmann, Gernot Reishofer
BACKGROUND: Diffusion weighted (DW) cardiovascular magnetic resonance (CMR) has shown great potential to discriminate between healthy and diseased vessel tissue by evaluating the apparent diffusion coefficient (ADC) along the arterial axis. Recently, ex vivo studies on porcine arteries utilizing diffusion tensor imaging (DTI) revealed a circumferential fiber orientation rather than an organization in axial direction, suggesting dominant diffusion perpendicular to the slice direction. In the present study, we propose a method to access tangential and radial diffusion of carotids in vivo by utilizing a pulse sequence that enables high resolution DW imaging in combination with a two-dimensional (2D) diffusion gradient direction sampling scheme perpendicular to the longitudinal axis of the artery...
November 23, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27866381/cardiac-magnetic-resonance-imaging-of-patent-ductus-arteriosus-in-three-dogs
#8
Youngjae Lee, Jaihyun Jung, Junyong Park, Jiyoon Jeong, Seokho Jeon, Sunyoung Park, Jinhwa Chang, Ji-Houn Kang, Chulhyun Lee, Dongwoo Chang
Patent ductus arteriosus (PDA) is the most common congenital cardiovascular disorder in dogs and requires an accurate diagnosis for an appropriate treatment. Cardiac MRI (cMRI) has been reported as a method for characterization of canine thoracic vasculature. However, to the authors' knowledge, no published studies describe evaluation of canine PDA through cMRI. Three dogs were selected for this exploratory study. Electrocardiogram gating and breath-hold techniques were performed using a 3T MR scanner. Both black blood imaging and bright blood cine acquisitions were performed...
November 20, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27865200/a-review-of-comparative-studies-of-mitraclip-versus-surgical-repair-for-mitral-regurgitation
#9
Hisato Takagi, Tomo Ando, Takuya Umemoto
OBJECTIVES: We summarized comparative studies of MitraClip versus surgical repair for mitral regurgitation (MR) with a systematic literature search and meta-analytic estimates. METHODS: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched through June 2016. Eligible studies were randomized controlled or observational comparative studies of MitraClip versus surgical repair enrolling patients with MR and reporting early (30-day or in-hospital) or late (≥6-month including early) all-cause mortality...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27844220/respiratory-optimized-data-selection-for-more-resilient-self-navigated-whole-heart-coronary-mr-angiography
#10
Jerome Chaptinel, Davide Piccini, Gabriele Bonanno, Simone Coppo, Pierre Monney, Matthias Stuber, Juerg Schwitter
OBJECTIVES: Our objective was to test a data-exclusion strategy for respiratory motion suppression by retrospectively eliminating data acquired at extreme respiratory positions for improved coronary vessel sharpness (VS) of 1-D self-navigated 3-D radial whole-heart coronary angiography acquisitions. MATERIALS AND METHODS: 3-D radial self-navigated acquisitions were performed on a 1.5T scanner in volunteers during free-breathing (n = 8), in coached volunteers (n = 13) who were asked to breathe in a controlled manner to mimic cardiovascular patients presenting with Cheyne-Stokes breathing, and in free-breathing patients (n = 20)...
November 14, 2016: Magma
https://www.readbyqxmd.com/read/27830348/steroidal-and-novel-non-steroidal-mineralocorticoid-receptor-antagonists-in-heart-failure-and-cardiorenal-diseases-comparison-at-bench-and-bedside
#11
Peter Kolkhof, Frederic Jaisser, So-Young Kim, Gerasimos Filippatos, Christina Nowack, Bertram Pitt
Characterization of mice with cell-specific deletion or overexpression of the mineralocorticoid receptor (MR) shed a new light on its role in health and disease. Pathophysiological MR activation contributes to a plethora of deleterious molecular mechanisms in the development of cardiorenal diseases like chronic kidney disease (CKD) and heart failure (HF). Accordingly, the available steroidal MR antagonists (MRAs) spironolactone (first generation MRA) and eplerenone (second generation MRA) have been shown to be effective in reducing cardiovascular (CV) mortality and morbidity in patients with chronic HF and a reduced left ventricular ejection fraction (HFrEF)...
November 10, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27816803/lumen-segmentation-in-magnetic-resonance-images-of-the-carotid-artery
#12
Danilo Samuel Jodas, Aledir Silveira Pereira, João Manuel R S Tavares
Investigation of the carotid artery plays an important role in the diagnosis of cerebrovascular events. Segmentation of the lumen and vessel wall in Magnetic Resonance (MR) images is the first step towards evaluating any possible cardiovascular diseases like atherosclerosis. However, the automatic segmentation of the lumen is still a challenge due to the low quality of the images and the presence of other elements such as stenosis and malformations that compromise the accuracy of the results. In this article, a method to identify the location of the lumen without user interaction is presented...
December 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27815793/cardiovascular-magnetic-resonance-in-patients-with-magnetic-resonance-conditional-pacemaker-systems-at-1-5%C3%A2-t-influence-of-pacemaker-related-artifacts-on-image-quality-including-first-pass-perfusion-aortic-and-mitral-valve-assessment-flow-measurement-short
#13
REVIEW
Oliver Klein-Wiele, Marietta Garmer, Martin Busch, Serban Mateiescu, Rhyan Urbien, Gianluca Barbone, Kaffer Kara, Michael Schulte-Hermes, Frauke Metz, Birgit Hailer, Dietrich Grönemeyer
There are only limited data on the impact of device-related artifacts on image quality in cardiovascular magnetic resonance imaging (CMR) in patients with pacemakers (PM). Adenosine stress perfusion, T1-weighted imaging and flow measurement as well as valve characterization have not been evaluated previously concerning artifact burden. We aimed to assess image quality in all routinely used CMR sequences. We analyzed 2623 myocardial segments in CMR scans of 61 patients with MR conditional PM (mean age 72.1 ± 11...
November 4, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27788594/the-prognostic-value-of-mr-proadrenomedullin-in-patients-with-acute-coronary-syndrome-complicated-by-cardiogenic-shock
#14
Karolina Supeł, Michał Kacprzak, Marzenna Zielińska
CONTEXT: Cardiogenic shock (CS) still remains one of the main causes of death in AMI. OBJECTIVE: The aim of this study was to evaluate the prognostic value of MR-proadrenomedullin in AMI complicated by CS. METHODS: 47 consecutive patients were included in our prospective observational study. All patients underwent coronarography and successful PCI. Plasma levels of MR-proADM were measured by a immunofluorescence method. The primary endpoint of the study, defined as cardiovascular death, occurred in 17 patients (36%)...
October 28, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27770583/a-population-based-study-of-chronic-myeloid-leukemia-patients-treated-with-imatinib-in-first-line
#15
Fausto Castagnetti, Francesco Di Raimondo, Antonio De Vivo, Antonio Spitaleri, Gabriele Gugliotta, Francesco Fabbiano, Isabella Capodanno, Donato Mannina, Marzia Salvucci, Agostino Antolino, Roberto Marasca, Maurizio Musso, Monica Crugnola, Stefana Impera, Elena Trabacchi, Caterina Musolino, Francesco Cavazzini, Giuseppe Mineo, Patrizia Tosi, Carmela Tomaselli, Michele Rizzo, Sergio Siragusa, Miriam Fogli, Riccardo Ragionieri, Alessandro Zironi, Simona Soverini, Giovanni Martinelli, Michele Cavo, Paolo Vigneri, Fabio Stagno, Gianantonio Rosti, Michele Baccarani
Chronic myeloid leukemia (CML) treatment is based on company-sponsored and academic trials testing different tyrosine kinase inhibitors (TKIs) as first-line therapy. These studies included patients selected according to many inclusion-exclusion criteria, particularly age and comorbidities, with specific treatment obligations. In daily clinical practice (real-life), inclusion-exclusion criteria do not exist and the treatment outcome does not only depend on the choice of first-line TKI, but also on second- and third-line TKIs...
October 22, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27768686/effect-of-insulin-resistance-on-monounsaturated-fatty-acid-levels-a-multi-cohort-non-targeted-metabolomics-and-mendelian-randomization-study
#16
Christoph Nowak, Samira Salihovic, Andrea Ganna, Stefan Brandmaier, Taru Tukiainen, Corey D Broeckling, Patrik K Magnusson, Jessica E Prenni, Rui Wang-Sattler, Annette Peters, Konstantin Strauch, Thomas Meitinger, Vilmantas Giedraitis, Johan Ärnlöv, Christian Berne, Christian Gieger, Samuli Ripatti, Lars Lind, Nancy L Pedersen, Johan Sundström, Erik Ingelsson, Tove Fall
Insulin resistance (IR) and impaired insulin secretion contribute to type 2 diabetes and cardiovascular disease. Both are associated with changes in the circulating metabolome, but causal directions have been difficult to disentangle. We combined untargeted plasma metabolomics by liquid chromatography/mass spectrometry in three non-diabetic cohorts with Mendelian Randomization (MR) analysis to obtain new insights into early metabolic alterations in IR and impaired insulin secretion. In up to 910 elderly men we found associations of 52 metabolites with hyperinsulinemic-euglycemic clamp-measured IR and/or β-cell responsiveness (disposition index) during an oral glucose tolerance test...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27756783/plasma-lipidomic-profiles-improve-upon-traditional-risk-factors-for-the-prediction-of-cardiovascular-events-in-type-2-diabetes
#17
Zahir H Alshehry, Piyushkumar A Mundra, Christopher K Barlow, Natalie A Mellett, Gerard Wong, Malcolm J McConville, John Simes, Andrew M Tonkin, David R Sullivan, Elizabeth H Barnes, Paul J Nestel, Bronwyn A Kingwell, Michel Marre, Bruce Neal, Neil R Poulter, Anthony Rodgers, Bryan Williams, Sophia Zoungas, Graham S Hillis, John Chalmers, Mark Woodward, Peter J Meikle
BACKGROUND: -Clinical lipid measurements do not show the full complexity of the altered lipid metabolism associated with diabetes or cardiovascular disease. Lipidomics enables the assessment of hundreds of lipid species as potential markers for disease risk. METHODS: -Plasma lipid species (310) were measured by a targeted lipidomic analysis with liquid chromatography electrospray ionisation-tandem mass spectrometry on a case-cohort (n=3,779) subset from the ADVANCE (Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation) trial...
October 18, 2016: Circulation
https://www.readbyqxmd.com/read/27754204/apsh-yi-03-essential-role-of-intestinal-epithelial-mineralocorticoid-receptor-in-the-regulation-of-sodium-absorption-and-blood-pressure
#18
Toshifumi Nakamura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Yuko Mitsuishi, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Gunther Schutz, Hirotaka Shibata, Hiroshi Itoh
OBJECTIVE: Recent studies have unveiled cardiovascular pathological roles of mineralocorticoid receptor (MR) in many types of cells. Although we have confirmed high expression of MR in intestinal epithelial cells (IEC), that role in progression of cardiovascular diseases is yet to be elucidated. As intestine is the first gate sensing sodium intake, MR of this organ is expected to have essential roles in blood pressure (BP) regulation. This study investigated the role of MR in IEC by using IEC-specific MR knockout mice (IEC-MR KO)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27747165/use-of-bio-informatics-assessment-schema-bias-to-improve-diagnosis-and-prognosis-of-myocardial-perfusion-data-results-from-the-nhlbi-sponsored-women-s-ischemia-syndrome-evaluation-wise
#19
Mark Doyle, Gerald M Pohost, C Noel Bairey Merz, Leslee J Shaw, George Sopko, William J Rogers, Barry L Sharaf, Carl J Pepine, Diane V Thompson, Geetha Rayarao, Lindsey Tauxe, Sheryl F Kelsey, Robert W W Biederman
BACKGROUND: We introduce an algorithmic approach to optimize diagnostic and prognostic value of gated cardiac single photon emission computed tomography (SPECT) and magnetic resonance (MR) myocardial perfusion imaging (MPI) modalities in women with suspected myocardial ischemia. The novel approach: bio-informatics assessment schema (BIAS) forms a mathematical model utilizing MPI data and cardiac metrics generated by one modality to predict the MPI status of another modality. The model identifies cardiac features that either enhance or mask the image-based evidence of ischemia...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27738481/prognostic-importance-of-exercise-brain-natriuretic-peptide-in-asymptomatic-chronic-organic-severe-mitral-regurgitation-an-observational-study
#20
Santosh Kumar Sinha, Shalini Garg, Ramesh Thakur, Vinay Krishna, Karandeep Singh, Mohit Sachan, Amit Goel, Mahamdula Razi, Umeshwar Pandey, Chandra Mohan Varma
BACKGROUND: The optimal timing of surgery in patients with chronic organic severe mitral regurgitation (MR) continues to be debated, especially for those who are asymptomatic. The aim of the study was to determine independent and additive prognostic value of exercise brain natriuretic peptide (eBNP) in patients with severe asymptomatic MR and normal left ventricular ejection fraction (LVEF). METHODS: Two hundred twenty-three consecutive patients with severe MR defined by effective regurgitant orifice (ERO) area ≥ 40 mm(2) and/or residual volume ≥ 60 mL, LVEF > 60%, and normal LV end-systolic diameter < 40 mm underwent symptom limited exercise treadmill test (TMT)...
November 2016: Journal of Clinical Medicine Research
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