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Cardiovascular MR

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https://www.readbyqxmd.com/read/28725332/thyrotoxic-valvulopathy-case-report-and-review-of-the-literature
#1
Keniel Pierre, Sushee Gadde, Bassam Omar, G Mustafa Awan, Christopher Malozzi
We report a 42-year-old female who was admitted for abdominal pain, and also endorsed dyspnea, fatigue and chronic palpitations. Past medical history included asthma, patent ductus arteriosus repaired in childhood and ill-defined thyroid disease. Physical examination revealed blood pressure of 136/88 mm Hg and heart rate of 149 beats per minute. Cardiovascular exam revealed an irregularly irregular rhythm, and pulmonary exam revealed mild expiratory wheezing. Abdomen was tender. Electrocardiogram revealed atrial fibrillation with rapid ventricular response which responded to intravenous diltiazem...
June 2017: Cardiology Research
https://www.readbyqxmd.com/read/28705824/carotid-plaque-morphology-and-ischemic-vascular-brain-disease-on-mri
#2
Q J A van den Bouwhuijsen, M W Vernooij, B F J Verhaaren, H A Vrooman, W J Niessen, G P Krestin, M A Ikram, O H Franco, A van der Lugt
BACKGROUND AND PURPOSE: Vulnerable carotid plaque components are reported to increase the risk of cerebrovascular events. Yet, the relation between plaque composition and subclinical ischemic brain disease is not known. We studied, in the general population, the association between carotid atherosclerotic plaque characteristics and ischemic brain disease on MR imaging. MATERIALS AND METHODS: From the population-based Rotterdam Study, 951 participants underwent both carotid MR imaging and brain MR imaging...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28678672/acute-versus-chronic-myocardial-infarction-diagnostic-accuracy-of-quantitative-native-t1-and-t2-mapping-versus-assessment-of-edema-on-standard-t2-weighted-cardiovascular-mr-images-for-differentiation
#3
Enver Tahir, Martin Sinn, Sebastian Bohnen, Maxim Avanesov, Dennis Säring, Christian Stehning, Bernhard Schnackenburg, Christine Eulenburg, Joshua Wien, Ulf K Radunski, Stefan Blankenberg, Gerhard Adam, Charles B Higgins, Maythem Saeed, Kai Muellerleile, Gunnar K Lund
Purpose To analyze the diagnostic accuracy of native T1 and T2 mapping compared with visual and quantitative assessment of edema on T2-weighted cardiac magnetic resonance (MR) images to differentiate between acute and chronic myocardial infarction. Materials and Methods This study had institutional ethics committee approval. Written informed consent was obtained from 67 consecutive patients (57 years ± 12; 78% men) with a first acute myocardial infarction, who were prospectively enrolled between April 2011 and June 2015...
July 3, 2017: Radiology
https://www.readbyqxmd.com/read/28659549/predictors-and-clinical-impact-of-functional-mitral-stenosis-induced-by-restrictive-annuloplasty-for-ischemic-and-functional-mitral-regurgitation
#4
Satoshi Kainuma, Kazuhiro Taniguchi, Koichi Toda, Toshihiro Funatsu, Haruhiko Kondoh, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Shunsuke Saito, Takayoshi Ueno, Toru Kuratani, Takashi Daimon, Takafumi Masai, Yoshiki Sawa
BACKGROUND: There are few reports of the determinants of "functional" mitral stenosis in terms of a residual mitral valve (MV) pressure gradient >5 mmHg following restrictive mitral annuloplasty (RMA) or the effect on long-term outcome in patients with functional mitral regurgitation (MR).Methods and Results:Serial cardiac catheterization and echocardiographic studies were performed in 55 patients with functional MR who underwent RMA using a 24/26-mm semi-rigid complete ring. The mean postoperative (1 month) catheter-measured MV gradient was 3...
June 28, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28656465/strain-analysis-in-crt-candidates-using-the-novel-segment-length-in-cine-slice-post-processing-technique-on-standard-cmr-cine-images
#5
Alwin Zweerink, Cornelis P Allaart, Joost P A Kuijer, LiNa Wu, Aernout M Beek, Peter M van de Ven, Mathias Meine, Pierre Croisille, Patrick Clarysse, Albert C van Rossum, Robin Nijveldt
OBJECTIVES: Although myocardial strain analysis is a potential tool to improve patient selection for cardiac resynchronization therapy (CRT), there is currently no validated clinical approach to derive segmental strains. We evaluated the novel segment length in cine (SLICE) technique to derive segmental strains from standard cardiovascular MR (CMR) cine images in CRT candidates. METHODS: Twenty-seven patients with left bundle branch block underwent CMR examination including cine imaging and myocardial tagging (CMR-TAG)...
June 27, 2017: European Radiology
https://www.readbyqxmd.com/read/28651276/white-paper-interventional-mri-current-status-and-potential-for-development-considering-economic-perspectives-part-1-general-application
#6
Jörg Barkhausen, Thomas Kahn, Gabriele A Krombach, Christiane K Kuhl, Joachim Lotz, David Maintz, Jens Ricke, Stefan O Schönberg, Thomas J Vogl, Frank K Wacker
Background MRI is attractive for the guiding and monitoring of interventional procedures due to its high intrinsic soft tissue contrast and the possibility to measure physiologic parameters like flow and cardiac function. Method The current status of interventional MRI for the clinical routine was analyzed. Results The effort needed for the development of MR-safe monitoring systems and instruments initially resulted in the application of interventional MRI only for procedures that could not be performed by other means...
July 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28646674/a-multimodal-spatiotemporal-cardiac-motion-atlas-from-mr-and-ultrasound-data
#7
Esther Puyol-Antón, Matthew Sinclair, Bernhard Gerber, Mihaela Silvia Amzulescu, Hélène Langet, Mathieu De Craene, Paul Aljabar, Paolo Piro, Andrew P King
Cardiac motion atlases provide a space of reference in which the motions of a cohort of subjects can be directly compared. Motion atlases can be used to learn descriptors that are linked to different pathologies and which can subsequently be used for diagnosis. To date, all such atlases have been formed and applied using data from the same modality. In this work we propose a framework to build a multimodal cardiac motion atlas from 3D magnetic resonance (MR) and 3D ultrasound (US) data. Such an atlas will benefit from the complementary motion features derived from the two modalities, and furthermore, it could be applied in clinics to detect cardiovascular disease using US data alone...
June 13, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28641819/dynamic-contrast-enhanced-mr-imaging-of-carotid-vasa-vasorum-in-relation-to-coronary-and-cerebrovascular-events
#8
Juan Wang, Huijun Chen, Jie Sun, Daniel S Hippe, Huawei Zhang, Shengyuan Yu, Jianming Cai, Leixing Xie, Bao Cui, Chun Yuan, Xihai Zhao, Weimin Yuan, Hongbin Liu
BACKGROUND AND AIMS: Dynamic contrast-enhanced MR imaging (DCE-MRI) provides a noninvasive approach to the functional status of carotid adventitial vasa vasorum. Contrast extravasation rate, or K(trans), derived from kinetic modeling of adventitial enhancement, has been correlated with plaque neovascularization and inflammation. This study sought to clarify the clinical implications of K(trans) by evaluating its relationship with documented cardiovascular events (CVE). METHODS: Seventy patients with carotid plaque at clinical ultrasound examination were recruited and imaged with a previously-described bright-blood DCE-MRI protocol (spatial resolution: 0...
June 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28634267/30-years-of-the-mineralocorticoid-receptor-the-role-of-the-mineralocorticoid-receptor-in-the-vasculature
#9
REVIEW
Jennifer J DuPont, Iris Z Jaffe
Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that MR is expressed in extra-renal tissues, including the cardiovascular system, where it is expressed in all cells of the vasculature. Understanding the role of MR in the vasculature has been of particular interest as clinical trials show that MR antagonism improves cardiovascular outcomes out of proportion to changes in blood pressure. The last 30 years of research have demonstrated that MR is a functional hormone-activated transcription factor in vascular smooth muscle cells and endothelial cells...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28625371/cardiovascular-events-and-hospital-resource-utilization-pre-and-post-transcatheter-mitral-valve-repair-in-high-surgical-risk-patients
#10
Sreekanth Vemulapalli, Steven J Lippmann, Mitchell Krucoff, Adrian F Hernandez, Lesley H Curtis, Elyse Foster, Atif Qasim, Andrew Wang, Donald D Glower, Ted Feldman, Bradley G Hammill
MitraClip is an approved therapy for mitral regurgitation (MR); however, health care resource utilization pre- and post-MitraClip remains understudied. METHODS: Patients with functional and degenerative MR at high surgical risk in the EVEREST II High-Risk Registry and REALISM Continued-Access Study were linked to Medicare data. Pre- and post-MitraClip all-cause death, stroke, myocardial infarction, heart failure (HF), and bleeding hospitalizations were identified. Inpatient costs, adjusted to 2010 US dollars, were calculated, and event rate ratios and cost ratios were estimated with multivariable modeling...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28624970/cardiovascular-implantable-electronic-devices-a-review-of-the-dangers-and-difficulties-in-mr-scanning-and-attempts-to-improve-safety
#11
REVIEW
Pei Ghim Poh, Charlene Liew, Colin Yeo, Le Roy Chong, Andrew Tan, Angeline Poh
An increasing number of patients are being treated with cardiovascular implantable electronic devices (CIEDs), many of which are MR conditional. There is a lack of literature on the safe scanning of MR conditional CIEDs. This review article discusses MR imaging safety in patients with implanted CIEDs. Guidelines on safe use and indications of imaging patients with MR conditional CIEDs are described, followed by a pictorial essay of the radiographic features of these devices. We also discuss the challenges of monitoring the patient in the MR environment, advances in MRI conditional imaging of devices, availability, limitations and workflow including vendor-specific and other collaborative efforts to simplify the scanning process...
August 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28615141/diagnostic-capability-of-feature-tracking-cardiovascular-magnetic-resonance-to-detect-infarcted-segments-a-comparison-with-tagged-magnetic-resonance-and-wall-thickening-analysis
#12
R Ogawa, T Kido, M Nakamura, T Kido, A Kurata, M Miyagawa, T Mochizuki
AIM: To examine the diagnostic capabilities of feature-tracking cardiovascular magnetic resonance (FT-CMR), tagged cine magnetic resonance (MR), and wall thickening (WT) analyses to detect infarcted segments in patients with established myocardial infarction (MI). MATERIALS AND METHODS: Twenty patients with established MI were selected retrospectively and the peak endocardial circumferential strain (CS) was quantified based on the 16-segment model. According to CMR with late gadolinium enhancement, segments were categorised as transmural MI, subendocardial MI, and no MI...
June 11, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28611666/mineralocorticoid-receptor-signaling-as-a-therapeutic-target-for-renal-and-cardiac-fibrosis
#13
REVIEW
Greg H Tesch, Morag J Young
Activation of the mineralocorticoid receptor (MR) plays important roles in both physiological and pathological events. Blockade of MR signaling with MR antagonists (MRAs) has been used clinically to treat kidney and cardiac disease associated with hypertension and other chronic diseases, resulting in suppression of fibrosis in these organs. However, the current use of steroidal MRAs has been limited by off target effects on other hormone receptors or adverse effects on kidney tubular function. In this review, we summarize recent insights into the profibrotic roles of MR signaling in kidney and cardiovascular disease...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28580809/cardiovascular-imaging-environment-will-the-future-be-cloud-based
#14
Nadine Kawel-Boehm, David A Bluemke
In cardiovascular CT and MR imaging large datasets have to be stored, post-processed, analyzed and distributed. Beside basic assessment of volume and function in cardiac magnetic resonance imaging e.g., more sophisticated quantitative analysis is requested requiring specific software. Several institutions cannot afford various types of software and provide expertise to perform sophisticated analysis. Areas covered: Various cloud services exist related to data storage and analysis specifically for cardiovascular CT and MR imaging...
June 13, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28577544/deactivation-vs-asynchronous-pacing-prospective-evaluation-of-a-protocol-for-rhythm-management-in-patients-with-magnetic-resonance-conditional-pacemakers-undergoing-adenosine-stress-cardiovascular-magnetic-resonance-imaging
#15
Oliver Klein-Wiele, Marietta Garmer, Gianluca Barbone, Rhyan Urbien, Martin Busch, Kaffer Kara, Harald Schäfer, Michael Schulte-Hermes, Birgit Hailer, Dietrich Grönemeyer
BACKGROUND: Cardiovascular Magnetic Resonance (CMR) imaging with adenosine stress is an important diagnostic tool in patients with known or suspected coronary artery disease (CAD). However, the method is not yet established for CAD patients with pacemakers (PM) in clinical practice. A possible reason is that no recommendations exist for PM setting (paused pacing or asynchronous mode) during adenosine stress. We elaborated a protocol for rhythm management in clinical routine for PM patients that considers heart rate changes under adenosine using a test infusion of adenosine in selected patients...
June 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28562205/diameter-of-the-pulmonary-artery-in-relation-to-the-ascending-aorta-association-with-cardiovascular-outcome
#16
Andreas A Kammerlander, Stefan Aschauer, Caroline Zotter-Tufaro, Franz Duca, Klaus Knechtelsdorfer, Matthias Wiesinger, Marianne L Schwaiger, Daniel Dalos, Matthias Schneider, Beatrice A Marzluf, Diana Bonderman, Julia Mascherbauer
Purpose To investigate whether the pulmonary artery (PA)-to-ascending aorta (Ao) ratio is associated with outcome in unselected patients referred for cardiac magnetic resonance (MR) imaging. Materials and Methods This study prospectively enrolled 650 consecutive patients (47.2% women; mean age, 56.1 years ± 17.7 [standard deviation]). Diameters of PA and Ao were measured in axial black blood images. On the basis of previous results, a PA-to-Ao ratio of 1.0 or greater was chosen as the cutoff for further analysis...
May 29, 2017: Radiology
https://www.readbyqxmd.com/read/28558715/modern-peptide-biomarkers-and-echocardiography-in-cardiac-healthy-haemodialysis-patients
#17
Franz Maximilian Rasche, Stephan Stoebe, Thomas Ebert, Silvana Feige, Andreas Hagendorff, Wilma Gertrud Rasche, Filip Barinka, Volker Busch, Ulrich Sack, Jochen G Schneider, Stephan Schiekofer
BACKGROUND: In this prospective study, we aimed to assess the haemodynamic changes before and after haemodialysis (HD) in cardiac healthy subjects on chronic HD by imaging methods and endocrine markers of fluid balance. METHODS: Mid-regional pro-atrial natriuretic peptide (MR-proANP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), vasopressin (AVP) and copeptin (CT-proAVP), metanephrines and normetanephrines, renin and aldosterone, standard transthoracic echocardiography and diameter of vena cava inferior (VCID) were performed in 20 patients with end stage renal disease (CKD5D) before and after HD and were stratified in residual excretion (RE, less or more 0...
May 30, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28555959/design-of-the-magnetic-resonance-imaging-evaluation-of-mineralocorticoid-receptor-antagonism-in-diabetic-atherosclerosis-magma-trial
#18
Sanjay Rajagopalan, M Amer Alaiti, Kylene Broadwater, Aditya Goud, Juan Gaztanaga, Kim Connelly, Anas Fares, Shayan Shirazian, Catherine Kreatsoulas, Michael Farkouh, Mirela Dobre, Jeffrey C Fink, Matthew R Weir
Mineralocorticoid receptor (MR) activation plays an essential role in promoting inflammation, fibrosis, and target organ damage. Currently, no studies are investigating MR antagonism in patients with type 2 diabetes mellitus (T2DM) with chronic kidney disease, at high risk for cardiovascular complications, who are otherwise not candidates for MR antagonism by virtue of heart failure. Further, there is limited information on candidate therapies that may demonstrate differential benefit from this therapy. We hypothesized that MR antagonism may provide additional protection from atherosclerosis progression in higher-risk patients who otherwise may not be candidates for such a therapeutic approach...
May 26, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28550025/30-years-of-the-mineralocorticoid-receptor-mineralocorticoid-receptor-null-mice-informing-cell-type-specific-roles
#19
REVIEW
Timothy J Cole, Morag J Young
The mineralocorticoid receptor (MR) mediates the actions of two important adrenal corticosteroid hormones, aldosterone and cortisol. The cell signalling roles of the MR in vivo have expanded enormously since the cloning of human MR gene 30 years ago and the first MR gene knockout in mice nearly 20 years ago. Complete ablation of the MR revealed important roles postnatally for regulation of kidney epithelial functions, with MR-null mice dying 1-2 weeks postnatally from renal salt wasting and hyperkalaemia, with elevated plasma renin and aldosterone...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28540979/alcohol-consumption-aldehyde-dehydrogenase-2-gene-polymorphisms-and-cardiovascular-health-in-korea
#20
REVIEW
Min Jeong Shin, Yoonsu Cho, George Davey Smith
Alcohol consumption is a serious health issue in Korea in terms of the amount consumed and the behavior related to its consumption. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol metabolism that degrades acetaldehyde to nontoxic acetic acid. The enzyme is coded by the ALDH2 gene, which is commonly polymorphic in East Asian populations. A point mutation in the ALDH2 gene (the rs671 allele) yields an inactive form of ALDH2 that causes acetaldehyde accumulation in the body after alcohol consumption, thereby inhibiting normal alcohol metabolism...
July 2017: Yonsei Medical Journal
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