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Cardiovascular MR

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https://www.readbyqxmd.com/read/28634267/30-years-of-the-mineralocorticoid-receptor-the-role-of-the-mineralocorticoid-receptor-in-the-vasculature
#1
REVIEW
Jennifer J DuPont, Iris Z Jaffe
Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that MR is expressed in extra-renal tissues, including the cardiovascular system, where it is expressed in all cells of the vasculature. Understanding the role of MR in the vasculature has been of particular interest as clinical trials show that MR antagonism improves cardiovascular outcomes out of proportion to changes in blood pressure. The last 30 years of research have demonstrated that MR is a functional hormone-activated transcription factor in vascular smooth muscle cells and endothelial cells...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28625371/cardiovascular-events-and-hospital-resource-utilization-pre-and-post-transcatheter-mitral-valve-repair-in-high-surgical-risk-patients
#2
Sreekanth Vemulapalli, Steven J Lippmann, Mitchell Krucoff, Adrian F Hernandez, Lesley H Curtis, Elyse Foster, Atif Qasim, Andrew Wang, Donald D Glower, Ted Feldman, Bradley G Hammill
MitraClip is an approved therapy for mitral regurgitation (MR); however, health care resource utilization pre- and post-MitraClip remains understudied. METHODS: Patients with functional and degenerative MR at high surgical risk in the EVEREST II High-Risk Registry and REALISM Continued-Access Study were linked to Medicare data. Pre- and post-MitraClip all-cause death, stroke, myocardial infarction, heart failure (HF), and bleeding hospitalizations were identified. Inpatient costs, adjusted to 2010 US dollars, were calculated, and event rate ratios and cost ratios were estimated with multivariable modeling...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28624970/cardiovascular-implantable-electronic-devices-a-review-of-the-dangers-and-difficulties-in-mr-scanning-and-attempts-to-improve-safety
#3
REVIEW
Pei Ghim Poh, Charlene Liew, Colin Yeo, Le Roy Chong, Andrew Tan, Angeline Poh
An increasing number of patients are being treated with cardiovascular implantable electronic devices (CIEDs), many of which are MR conditional. There is a lack of literature on the safe scanning of MR conditional CIEDs. This review article discusses MR imaging safety in patients with implanted CIEDs. Guidelines on safe use and indications of imaging patients with MR conditional CIEDs are described, followed by a pictorial essay of the radiographic features of these devices. We also discuss the challenges of monitoring the patient in the MR environment, advances in MRI conditional imaging of devices, availability, limitations and workflow including vendor-specific and other collaborative efforts to simplify the scanning process...
June 17, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28615141/diagnostic-capability-of-feature-tracking-cardiovascular-magnetic-resonance-to-detect-infarcted-segments-a-comparison-with-tagged-magnetic-resonance-and-wall-thickening-analysis
#4
R Ogawa, T Kido, M Nakamura, T Kido, A Kurata, M Miyagawa, T Mochizuki
AIM: To examine the diagnostic capabilities of feature-tracking cardiovascular magnetic resonance (FT-CMR), tagged cine magnetic resonance (MR), and wall thickening (WT) analyses to detect infarcted segments in patients with established myocardial infarction (MI). MATERIALS AND METHODS: Twenty patients with established MI were selected retrospectively and the peak endocardial circumferential strain (CS) was quantified based on the 16-segment model. According to CMR with late gadolinium enhancement, segments were categorised as transmural MI, subendocardial MI, and no MI...
June 11, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28611666/mineralocorticoid-receptor-signaling-as-a-therapeutic-target-for-renal-and-cardiac-fibrosis
#5
REVIEW
Greg H Tesch, Morag J Young
Activation of the mineralocorticoid receptor (MR) plays important roles in both physiological and pathological events. Blockade of MR signaling with MR antagonists (MRAs) has been used clinically to treat kidney and cardiac disease associated with hypertension and other chronic diseases, resulting in suppression of fibrosis in these organs. However, the current use of steroidal MRAs has been limited by off target effects on other hormone receptors or adverse effects on kidney tubular function. In this review, we summarize recent insights into the profibrotic roles of MR signaling in kidney and cardiovascular disease...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28580809/cardiovascular-imaging-environment-will-the-future-be-cloud-based
#6
Nadine Kawel-Boehm, David A Bluemke
In cardiovascular CT and MR imaging large datasets have to be stored, post-processed, analyzed and distributed. Beside basic assessment of volume and function in cardiac magnetic resonance imaging e.g., more sophisticated quantitative analysis is requested requiring specific software. Several institutions cannot afford various types of software and provide expertise to perform sophisticated analysis. Areas covered: Various cloud services exist related to data storage and analysis specifically for cardiovascular CT and MR imaging...
June 13, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28577544/deactivation-vs-asynchronous-pacing-prospective-evaluation-of-a-protocol-for-rhythm-management-in-patients-with-magnetic-resonance-conditional-pacemakers-undergoing-adenosine-stress-cardiovascular-magnetic-resonance-imaging
#7
Oliver Klein-Wiele, Marietta Garmer, Gianluca Barbone, Rhyan Urbien, Martin Busch, Kaffer Kara, Harald Schäfer, Michael Schulte-Hermes, Birgit Hailer, Dietrich Grönemeyer
BACKGROUND: Cardiovascular Magnetic Resonance (CMR) imaging with adenosine stress is an important diagnostic tool in patients with known or suspected coronary artery disease (CAD). However, the method is not yet established for CAD patients with pacemakers (PM) in clinical practice. A possible reason is that no recommendations exist for PM setting (paused pacing or asynchronous mode) during adenosine stress. We elaborated a protocol for rhythm management in clinical routine for PM patients that considers heart rate changes under adenosine using a test infusion of adenosine in selected patients...
June 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28562205/diameter-of-the-pulmonary-artery-in-relation-to-the-ascending-aorta-association-with-cardiovascular-outcome
#8
Andreas A Kammerlander, Stefan Aschauer, Caroline Zotter-Tufaro, Franz Duca, Klaus Knechtelsdorfer, Matthias Wiesinger, Marianne L Schwaiger, Daniel Dalos, Matthias Schneider, Beatrice A Marzluf, Diana Bonderman, Julia Mascherbauer
Purpose To investigate whether the pulmonary artery (PA)-to-ascending aorta (Ao) ratio is associated with outcome in unselected patients referred for cardiac magnetic resonance (MR) imaging. Materials and Methods This study prospectively enrolled 650 consecutive patients (47.2% women; mean age, 56.1 years ± 17.7 [standard deviation]). Diameters of PA and Ao were measured in axial black blood images. On the basis of previous results, a PA-to-Ao ratio of 1.0 or greater was chosen as the cutoff for further analysis...
May 29, 2017: Radiology
https://www.readbyqxmd.com/read/28558715/modern-peptide-biomarkers-and-echocardiography-in-cardiac-healthy-haemodialysis-patients
#9
Franz Maximilian Rasche, Stephan Stoebe, Thomas Ebert, Silvana Feige, Andreas Hagendorff, Wilma Gertrud Rasche, Filip Barinka, Volker Busch, Ulrich Sack, Jochen G Schneider, Stephan Schiekofer
BACKGROUND: In this prospective study, we aimed to assess the haemodynamic changes before and after haemodialysis (HD) in cardiac healthy subjects on chronic HD by imaging methods and endocrine markers of fluid balance. METHODS: Mid-regional pro-atrial natriuretic peptide (MR-proANP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), vasopressin (AVP) and copeptin (CT-proAVP), metanephrines and normetanephrines, renin and aldosterone, standard transthoracic echocardiography and diameter of vena cava inferior (VCID) were performed in 20 patients with end stage renal disease (CKD5D) before and after HD and were stratified in residual excretion (RE, less or more 0...
May 30, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28555959/design-of-the-magnetic-resonance-imaging-evaluation-of-mineralocorticoid-receptor-antagonism-in-diabetic-atherosclerosis-magma-trial
#10
Sanjay Rajagopalan, M Amer Alaiti, Kylene Broadwater, Aditya Goud, Juan Gaztanaga, Kim Connelly, Anas Fares, Shayan Shirazian, Catherine Kreatsoulas, Michael Farkouh, Mirela Dobre, Jeffrey C Fink, Matthew R Weir
Mineralocorticoid receptor (MR) activation plays an essential role in promoting inflammation, fibrosis, and target organ damage. Currently, no studies are investigating MR antagonism in patients with type 2 diabetes mellitus (T2DM) with chronic kidney disease, at high risk for cardiovascular complications, who are otherwise not candidates for MR antagonism by virtue of heart failure. Further, there is limited information on candidate therapies that may demonstrate differential benefit from this therapy. We hypothesized that MR antagonism may provide additional protection from atherosclerosis progression in higher-risk patients who otherwise may not be candidates for such a therapeutic approach...
May 26, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28550025/30-years-of-the-mineralocorticoid-receptor-mineralocorticoid-receptor-null-mice-informing-cell-type-specific-roles
#11
REVIEW
Timothy J Cole, Morag J Young
The mineralocorticoid receptor (MR) mediates the actions of two important adrenal corticosteroid hormones, aldosterone and cortisol. The cell signalling roles of the MR in vivo have expanded enormously since the cloning of human MR gene 30 years ago and the first MR gene knockout in mice nearly 20 years ago. Complete ablation of the MR revealed important roles postnatally for regulation of kidney epithelial functions, with MR-null mice dying 1-2 weeks postnatally from renal salt wasting and hyperkalaemia, with elevated plasma renin and aldosterone...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28540979/alcohol-consumption-aldehyde-dehydrogenase-2-gene-polymorphisms-and-cardiovascular-health-in-korea
#12
REVIEW
Min Jeong Shin, Yoonsu Cho, George Davey Smith
Alcohol consumption is a serious health issue in Korea in terms of the amount consumed and the behavior related to its consumption. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol metabolism that degrades acetaldehyde to nontoxic acetic acid. The enzyme is coded by the ALDH2 gene, which is commonly polymorphic in East Asian populations. A point mutation in the ALDH2 gene (the rs671 allele) yields an inactive form of ALDH2 that causes acetaldehyde accumulation in the body after alcohol consumption, thereby inhibiting normal alcohol metabolism...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28522646/mr-spectroscopy-of-hepatic-fat-and-adiponectin-and-leptin-levels-during-testosterone-therapy-in-type-2-diabetes-a-randomized-double-blinded-placebo-controlled-trial
#13
Line Velling Magnussen, Poul Erik Andersen, Anabel Diaz, Jelena Markovic Ostojic, Kurt Højlund, David M Hougaard, Anders Nymark Christensen, Torben Leo Nielsen, Marianne Skovsager Andersen
BACKGROUND: Men with type 2 diabetes mellitus (T2D) often have lowered testosterone levels and an increased risk of cardiovascular disease (CVD). Ectopic fat increases the risk of CVD, whereas subcutaneous gluteofemoral fat protects against CVD and has a beneficial adipokine secreting profile. HYPOTHESIS: Testosterone replacement therapy (TRT) may reduce the content of ectopic fat and improve the adipokine profile in men with T2D. DESIGN AND METHODS: A randomized, double-blinded, placebo-controlled study in 39 men aged 50-70 years with T2D and bioavailable testosterone levels <7...
May 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28492512/aldosterone-and-mineralocorticoid-receptors-physiology-and-pathophysiology
#14
John W Funder
Aldosterone is a uniquely terrestrial hormone, first appearing in lungfish, which have both gills and lungs. Mineralocorticoid receptors (MRs), on the other hand, evolved much earlier, and are found in cartilaginous and bony fish, presumptive ligand cortisol. MRs have equivalent high affinity for aldosterone, progesterone, and cortisol; in epithelia, despite much higher cortisol circulating levels, aldosterone selectively activates MRs by co-expression of the enzyme 11β-hydroxysteroid dehydrogenase, Type 11...
May 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28486936/effects-of-inaccuracies-in-arterial-path-length-measurement-on-differences-in-mri-and-tonometry-measured-pulse-wave-velocity
#15
Jonathan R Weir-McCall, Faisel Khan, Deirdre B Cassidy, Arsh Thakur, Jennifer Summersgill, Shona Z Matthew, Fiona Adams, Fiona Dove, Stephen J Gandy, Helen M Colhoun, Jill Jf Belch, J Graeme Houston
BACKGROUND: Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf.-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements. METHODS: One hundred fourteen study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) (n = 23), T2DM without CVD (n = 41), CVD without T2DM (n = 25) and a control group (n = 25)...
May 10, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28477167/cardiovascular-magnetic-resonance-myocardial-t1-mapping-to-detect-and-quantify-cardiac-involvement-in-familial-amyloid-polyneuropathy
#16
Seitaro Oda, Daisuke Utsunomiya, Kosuke Morita, Takeshi Nakaura, Hideaki Yuki, Masafumi Kidoh, Kenichiro Hirata, Narumi Taguchi, Noriko Tsuda, Shinya Shiraishi, Tomohiro Namimoto, Kyoko Hirakawa, Seiji Takashio, Yasuhiro Izumiya, Megumi Yamamuro, Seiji Hokimoto, Kenichi Tsujita, Mitsuharu Ueda, Taro Yamashita, Yukio Ando, Yasuyuki Yamashita
OBJECTIVES: This study sought to explore the potential role of non-contrast T1 mapping for the detection and quantification of cardiac involvement in familial amyloid polyneuropathy (FAP). METHODS: Japanese patients with FAP [n = 41, age 53.2 ± 13.9 years, genotype Val30Met (n = 25), non-Val30Met (n = 16)] underwent cardiac magnetic resonance imaging that included T1 mapping (saturation-recovery method) and late gadolinium-enhanced (LGE) imaging on a 3...
May 5, 2017: European Radiology
https://www.readbyqxmd.com/read/28476142/dipeptidyl-peptidase-4-dpp-4-inhibition-with-linagliptin-reduces-western-diet-induced-myocardial-traf3ip2-expression-inflammation-and-fibrosis-in-female-mice
#17
Annayya R Aroor, Javad Habibi, Hemanth Kumar Kandikattu, Mona Garro-Kacher, Brady Barron, Dongqing Chen, Melvin R Hayden, Adam Whaley-Connell, Shawn B Bender, Thomas Klein, Jaume Padilla, James R Sowers, Bysani Chandrasekar, Vincent G DeMarco
BACKGROUND: Diastolic dysfunction (DD), a hallmark of obesity and primary defect in heart failure with preserved ejection fraction, is a predictor of future cardiovascular events. We previously reported that linagliptin, a dipeptidyl peptidase-4 inhibitor, improved DD in Zucker Obese rats, a genetic model of obesity and hypertension. Here we investigated the cardioprotective effects of linagliptin on development of DD in western diet (WD)-fed mice, a clinically relevant model of overnutrition and activation of the renin-angiotensin-aldosterone system...
May 5, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28450039/characterization-of-chronic-aortic-and-mitral-regurgitation-undergoing-valve-surgery-using-cardiovascular-magnetic-resonance
#18
Christian L Polte, Sinsia A Gao, Åse A Johnsson, Kerstin M Lagerstrand, Odd Bech-Hanssen
Grading of chronic aortic regurgitation (AR) and mitral regurgitation (MR) by cardiovascular magnetic resonance (CMR) is currently based on thresholds, which are neither modality nor quantification method specific. Accordingly, this study sought to identify CMR-specific and quantification method-specific thresholds for regurgitant volumes (RVols), RVol indexes, and regurgitant fractions (RFs), which denote severe chronic AR or MR with an indication for surgery. The study comprised patients with moderate and severe chronic AR (n = 38) and MR (n = 40)...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28445310/diagnostic-accuracy-of-serum-alanine-aminotransferase-as-biomarker-for-nonalcoholic-fatty-liver-disease-and-insulin-resistance-in-healthy-subjects-using-3t-mr-spectroscopy
#19
Jose Luis Martin-Rodriguez, Jorge Gonzalez-Cantero, Alvaro Gonzalez-Cantero, Juan Pedro Arrebola, Jorge Luis Gonzalez-Calvin
Recognition of the close relationship of nonalcoholic fatty liver disease (NAFLD) with diabetes mellitus 2, obesity, metabolic syndrome, and cardiovascular disease has stimulated growing interest in NAFLD as a public health problem. Serum alanine aminotransferase (ALT) has been proposed as a marker of NAFLD, but levels are within the range currently considered "normal" in a large proportion of NAFLD subjects.The aim of the study was to determine the diagnostic accuracy of serum ALT for identifying individuals with NAFLD, using 3-Tesla (T) magnetic resonance spectroscopy (H-MRS)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28442717/the-biomarker-and-causal-roles-of-homoarginine-in-the-development-of-cardiometabolic-diseases-an-observational-and-mendelian-randomization-analysis
#20
Ilkka Seppälä, Niku Oksala, Antti Jula, Antti J Kangas, Pasi Soininen, Nina Hutri-Kähönen, Winfried März, Andreas Meinitzer, Markus Juonala, Mika Kähönen, Olli T Raitakari, Terho Lehtimäki
High L-homoarginine (hArg) levels are directly associated with several risk factors for cardiometabolic diseases whereas low levels predict increased mortality in prospective studies. The biomarker role of hArg in young adults remains unknown. To study the predictive value of hArg in the development of cardiometabolic risk factors and diseases, we utilized data on high-pressure liquid chromatography-measured hArg, cardiovascular risk factors, ultrasound markers of preclinical atherosclerosis and type 2 diabetes from the population-based Young Finns Study involving 2,106 young adults (54...
April 25, 2017: Scientific Reports
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