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https://www.readbyqxmd.com/read/29161399/global-lessons-developing-military-trauma-care-and-lessons-for-civilian-practice
#1
T Woolley, J A Round, M Ingram
The wars in Iraq and Afghanistan have helped to shape the modern Defence Medical Services. Many lessons were learnt including the need for rapid haemorrhage control, senior decision-making and the evolution of deployed transfusion support. These changes were implemented simultaneously with a coherent, end-to-end medical plan from point of wounding through to rehabilitation. Implementation of the medical plan is harmonious with the NHS trauma pathway, and is key to ensuring effective delivery. Military anaesthetists have a long pre-deployment training pathway starting with a Certificate of Completion of Training (CCT) in anaesthesia and/or critical care, and with an emphasis on military skills related to their specific role...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29160543/intraocular-pressure-and-central-corneal-thickness-in-full-term-newborns
#2
Claudia Cardoso Maestri Ferreira, Ivan Maynart Tavares
OBJECTIVE: The aim of this study was to determine the central corneal thickness (CCT) and intraocular pressure (IOP) in full-term newborns and to correlate these values with the following variables: weight, sex, and post-conception age (PCA). METHODS: IOP and CCT were determined in 52 full-term newborns with a mean gestational age of 39.43 ± 1.03 weeks and a mean birth weight of 3,273 ± 558 g. The mean age of the neonates at the time of taking the measurements was 1...
September 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29158354/confirmatory-tests-for-the-diagnosis-of-primary-aldosteronism-a-prospective-diagnostic-accuracy-study
#3
Ying Song, Shumin Yang, Wenwen He, Jinbo Hu, Qingfeng Cheng, Yue Wang, Ting Luo, Linqiang Ma, Qianna Zhen, Suhua Zhang, Mei Mei, Zhihong Wang, Hua Qing, Dennis Bruemmer, Bin Peng, Qifu Li
The diagnosis of primary aldosteronism typically requires at least one confirmatory test. The fludrocortisone suppression test is generally accepted as a reliable confirmatory test, but it is cumbersome. Evidence from accuracy studies of the saline infusion test (SIT) and the captopril challenge test (CCT) has provided conflicting results. This prospective study aimed to evaluate the diagnostic accuracy of the SIT and CCT using fludrocortisone suppression test as the reference standard. One hundred thirty-five patients diagnosed with primary aldosteronism and 101 patients diagnosed with essential hypertension who completed the 3 confirmatory tests were included for the diagnostic accuracy analysis...
November 20, 2017: Hypertension
https://www.readbyqxmd.com/read/29154991/the-rice-constans-like-protein-oscol15-suppresses-flowering-by-promoting-ghd7-and-repressing-rid1
#4
Weixun Wu, Yingxin Zhang, Miao Zhang, Xiaodeng Zhan, Xihong Shen, Ping Yu, Daibo Chen, Qunen Liu, Sittipun Sinumporn, Kashif Hussain, Shihua Cheng, Liyong Cao
The photoperiodic flowering pathway is one of the most important regulatory networks controlling flowering time in rice (Oryza sativa L.). Rice is a facultative short-day (SD) plant; flowering is promoted under inductive SD conditions and delayed under non-inductive long-day (LD) conditions. In rice, flowering inhibitor genes play an important role in maintaining the trade-off between reproduction and yield. In this study, we identified a novel floral inhibitor, OsCOL15, which encodes a CONSTANS-like transcription factor...
November 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29149998/computational-complexity-and-human-decision-making
#5
REVIEW
Peter Bossaerts, Carsten Murawski
The rationality principle postulates that decision-makers always choose the best action available to them. It underlies most modern theories of decision-making. The principle does not take into account the difficulty of finding the best option. Here, we propose that computational complexity theory (CCT) provides a framework for defining and quantifying the difficulty of decisions. We review evidence showing that human decision-making is affected by computational complexity. Building on this evidence, we argue that most models of decision-making, and metacognition, are intractable from a computational perspective...
December 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/29149876/impact-of-donor-graft-quality-on-deep-anterior-lamellar-keratoplasty-dalk
#6
Friederike Schaub, Philip Enders, Werner Adler, Björn O Bachmann, Claus Cursiefen, Ludwig M Heindl
BACKGROUND: To evaluate main features of donor tissue that may influence clinical outcome or complication rate after deep anterior lamellar keratoplasty (DALK). METHODS: Donor tissue parameters of 84 consecutive corneal donor grafts used for big-bubble DALK surgery between June 2011 and December 2014 in 84 eyes of 84 patients with disorders of anterior corneal stroma were correlated to clinical outcome parameters of recipient eyes 12 months after surgery and 3 months after total suture removal...
November 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29149450/a-prospective-observational-cohort-study-comparing-cancer-clinical-trial-availability-and-enrollment-between-early-adolescents-young-adults-and-children
#7
Stefanie M Thomas, Jemily Malvar, Henry Tran, Jared Shows, David R Freyer
BACKGROUND: Poor enrollment of adolescents and young adults (AYAs) (ages 15-39 years) onto cancer clinical trials (CCTs) may contribute to inferior survival gains compared with children. In this study, the authors assessed whether differences in CCT availability would explain lower CCT enrollment for early AYAs (eAYAs) (ages 15-21 years). METHODS: This prospective, observational cohort study was conducted at a single academic children's hospital. For consecutive patients who were newly diagnosed with cancer over a 13-month period, it was determined whether an appropriate CCT existed nationally or was available locally and whether enrollment on that CCT occurred...
November 17, 2017: Cancer
https://www.readbyqxmd.com/read/29148097/ce3-sensitized-tm3-mn2-doped-nayf4-colloidal-nanocrystals-intense-cool-white-light-from-phosphor-coated-uv-led
#8
Venkataramanan Mahalingam, Venkata N K B Adusumalli, Heramba V S R M Koppisetti
Intense white light emission is observed from colloidal single component NaYF4:Ce3+/Tm3+/Mn2+ nanocrystals. This combination is interesting as it uses Mn2+ ions instead of green and red emitting Ln3+ ions which are expensive and less abundant. The single band blue emission of Tm3+ ions was combined with the broadband greenish yellow emission of Mn2+ ions to produce strong white light emission using Ce3+ ions as excitation source. Interestingly, there is hardly any re-absorption of blue emission by Mn2+ ions and the spectrum matches the commercial Ce3+-doped YAG phosphor coated over blue LED...
November 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29145895/comparative-analysis-of-high-sensitivity-cardiac-troponin-i-and-t-for-their-association-with-coronary-computed-tomography-assessed-calcium-scoring-represented-by-the-agatston-score
#9
Jonas Rusnak, Michael Behnes, Thomas Henzler, Nadine Reckord, Nils Vogler, Mathias Meyer, Ursula Hoffmann, Michele Natale, Julia Hoffmann, Sonja Hamed, Kathrin Weidner, Siegfried Lang, Agnibh Mukherji, Holger Haubenreisser, Stefan O Schoenberg, Martin Borggrefe, Thomas Bertsch, Ibrahim Akin
BACKGROUND: This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD). METHODS: Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD...
November 16, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29144545/music-therapy-for-depression
#10
REVIEW
Sonja Aalbers, Laura Fusar-Poli, Ruth E Freeman, Marinus Spreen, Johannes Cf Ket, Annemiek C Vink, Anna Maratos, Mike Crawford, Xi-Jing Chen, Christian Gold
BACKGROUND: Depression is a highly prevalent mood disorder that is characterised by persistent low mood, diminished interest, and loss of pleasure. Music therapy may be helpful in modulating moods and emotions. An update of the 2008 Cochrane review was needed to improve knowledge on effects of music therapy for depression. OBJECTIVES: 1. To assess effects of music therapy for depression in people of any age compared with treatment as usual (TAU) and psychological, pharmacological, and/or other therapies...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29141198/longitudinal-change-in-central-corneal-thickness-in-the-tema-eye-survey
#11
Jean-Claude Mwanza, Samantha E Tulenko, Donald L Budenz, Elizabeth Mathenge, Leon H Herndon, Hanna Y Kim, Alyson Hall, Graham Hay-Smith, Alexander Spratt, Keith Barton
PURPOSE: To determine the change and rate of change in central corneal thickness (CCT) and their determinants. DESIGN: Longitudinal observational population-based study. METHODS: 758 normal and 58 glaucomatous subjects underwent complete eye examination, with CCT measurements at two separate visits. Change and rate of change in CCT were determined. Univariate and multivariate linear regression analyses were performed to determine the factors associated with change and rate of change...
November 12, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29139110/unconditional-cash-transfers-for-reducing-poverty-and-vulnerabilities-effect-on-use-of-health-services-and-health-outcomes-in-low-and-middle-income-countries
#12
REVIEW
Frank Pega, Sze Yan Liu, Stefan Walter, Roman Pabayo, Ruhi Saith, Stefan K Lhachimi
BACKGROUND: Unconditional cash transfers (UCTs; provided without obligation) for reducing poverty and vulnerabilities (e.g. orphanhood, old age or HIV infection) are a type of social protection intervention that addresses a key social determinant of health (income) in low- and middle-income countries (LMICs). The relative effectiveness of UCTs compared with conditional cash transfers (CCTs; provided so long as the recipient engages in prescribed behaviours such as using a health service or attending school) is unknown...
November 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29137506/measuring-the-impact-of-cash-transfers-and-behavioral-nudges-on-maternity-care-in-nairobi-kenya
#13
Jessica Cohen, Claire Rothschild, Ginger Golub, George N Omondi, Margaret E Kruk, Margaret McConnell
Many patients in low-income countries express preferences for high-quality health care but often end up with low-quality providers. We conducted a randomized controlled trial with pregnant women in Nairobi, Kenya, to analyze whether cash transfers, enhanced with behavioral "nudges," can help women deliver in facilities that are consistent with their preferences and are of higher quality. We tested two interventions. The first was a labeled cash transfer (LCT), which explained that the cash was to help women deliver where they wanted...
November 2017: Health Affairs
https://www.readbyqxmd.com/read/29126088/in-the-immuno-oncology-era-is-anti-pd-1-or-anti-pd-l1-immunotherapy-modifying-the-sensitivity-to-conventional-cancer-therapies
#14
Sandrine Aspeslagh, Margarida Matias, Virginia Palomar, Laurent Dercle, Emilie Lanoy, Jean-Charles Soria, Sophie Postel-Vinay
INTRODUCTION: The advent of anti-programmed death receptor-1/ligand-1 antibodies (anti-PD(L)1) is profoundly changing the therapeutic strategy of oncology. As anti-PD(L)1 modulate tumour microenvironment, it might impact sensitivity to conventional cancer therapy (CCT). Therefore, we explored whether sensitivity to CCT was different before and after anti-PD(L)1 therapy. METHODS: Patients who started anti-PD(L)1 treatment at Gustave Roussy Cancer Centre between February 2012 and December 2015, and who received at least one line of CCT immediately before and immediately after anti-PD(L)1, were eligible...
November 7, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29124079/identifying-more-reliable-parameters-for-the-detection-of-change-during-the-follow-up-of-mild-to-moderate-keratoconus-patients
#15
Ivo Guber, Colm McAlinden, François Majo, Ciara Bergin
Background: Reaching a consensus on which parameters are most reliable at detecting progressive keratoconus patients with serial topography imaging is not evident. The aim of the study was to isolate the parameters best positioned to detect keratoconus progression using the Pentacam HR® measures based on the respective limits of repeatability and range of measurement. Method: Using the Pentacam HR®, a tolerance index was calculated on anterior segment parameters in healthy and keratoconic eyes...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/29123345/effect-of-supportive-psychotherapy-on-mental-health-status-and-quality-of-life-of-female-cancer-patients-receiving-chemotherapy-for-recurrent-disease
#16
Anindita Mukherjee, Koustav Mazumder, Vikrant Kaushal, Sushmita Ghoshal
Context: Cancer patients receiving chemotherapy for their recurrent disease often report the presence of anxiety and depression. Aims: In the study, we intended to find out the mental health status and overall quality of life (QOL) of such patients and to identify the effect of supportive psychotherapy. Subjects and Methods: Forty cancer patients undergoing second or subsequent line chemotherapy(CCT) were selected for psychotherapy session...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29117418/keratoconus-screening-with-dynamic-biomechanical-in-vivo-scheimpflug-analyses-a-proof-of-concept-study
#17
Johannes Steinberg, Nazanin Eslami Amirabadi, Andreas Frings, Juliane Mehlan, Toam Katz, Stephan J Linke
PURPOSE: This proof-of-concept study was designed to analyze the ability of in vivo biomechanical corneal analyses with the corneal visualization Scheimpflug technology (CorvisST; Oculus Optikgeräte, Wetzlar, Germany) to differentiate between normal eyes and eyes with manifest keratoconus after strictly eliminating the potential confounding factors intraocular pressure (IOP) and central corneal thickness (CCT). METHODS: In this retrospective, cross-sectional study, after pairwise matching for CCT and IOP, 29 normal eyes and 29 keratoconic eyes (one eye from each patient) were selected as study population...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29111844/a-new-perspective-on-the-genetics-of-keratoconus-why-have-we-not-been-more-successful
#18
Hanne Valgaeren, Carina Koppen, Guy Van Camp
Twin studies and family studies suggest an important genetic basis for keratoconus (KC). Involvement and association of several genes with the disease has been reported. Additionally, genes associated with central corneal thickness (CCT) and corneal curvature (CC) via genome-wide association studies (GWAS), also potentially underlie KC. Although a long list of genes has been reported for KC, the evidence for a pathogenic role for most genes remains limited. Furthermore, if the involvement of the reported genes in KC development can be proven, they only account for a limited number of patients...
November 7, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29106690/metabolic-syndrome-and-associated-diseases-from-the-bench-to-the-clinic
#19
Donna L Mendrick, Anna Mae Diehl, Lisa S Topor, Rodney R Dietert, Yvonne Will, Michele A La Merrill, Sebastien Bouret, Vijayalaskshmi Varma, Kenneth L Hastings, Thaddeus T Schug, Susan G Emeigh Hart, Florence G Burleson
Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic, a Society of Toxicology Contemporary Concepts in Toxicology (CCT) workshop was held on March 11, 2017. The meeting was convened to raise awareness of metabolic syndrome and its associated diseases and serve as a melting pot with scientists of multiple disciplines (e.g., toxicologists, clinicians, regulators) so as to spur research and understanding of this condition. The criteria for metabolic syndrome include obesity, dyslipidemia (low HDL and/or elevated triglycerides), elevated blood pressure, and alterations in glucose metabolism...
November 2, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29105842/vuv-vis-photoluminescence-site-occupancy-and-thermal-resistance-properties-of-k4srsi3o9-ce3
#20
Zhao-Qing Liu, Jin He, Xiaoxuan Guo, Yibo Chen, Rui Shi, Yan Huang, Jing Zhang, Yufei Wang
In this work, a series of novel Ce3+ activated K4SrSi3O9 with bright blue light emitting under near-UV excitation has been developed by a facile solid-state reaction. Impressively, the luminescence of Ce3+-doped K4SrSi3O9 shows an excellent thermal-stable feature in a large temperature region. The detailed temperature/concentration-dependent luminescent properties of Ce3+ confirm that there are two different Ce3+ sites in K4SrSi3O9:Ce3+, and energy transfer (ET) mechanism from the high energy Ce(1)3+ sites to the low energy Ce(2)3+ sites has been demonstrated to be electric dipole-dipole (EDD) interaction...
November 5, 2017: Chemistry: a European Journal
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