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https://www.readbyqxmd.com/read/29786918/novel-genes-and-insights-in-complete-asthma-remission
#1
Judith M Vonk, Maartje A E Nieuwenhuis, F Nicole Dijk, Anne Boudier, Valerie Siroux, Emmanuelle Bouzigon, Nicole Probst-Hensch, Medea Imboden, Dirk Keidel, Don Sin, Yohan Bossé, Ke Hao, Maarten van den Berge, Alen Faiz, Gerard H Koppelman, Dirkje S Postma
BACKGROUND: Asthma is a chronic respiratory disease without a cure, though there exists spontaneous remission. Genome wide association(GWA) studies have pinpointed genes associated with asthma development, but did not investigate asthma remission. OBJECTIVES: We performed a GWA study to develop insights in asthma remission. METHODS: Clinical remission (ClinR) was defined by absence of asthma treatment and wheezing in the last year and asthma attacks in the last 3 years, and complete remission (ComR) similarly but additionally with normal lung function and absence of bronchial hyperresponsiveness (BHR)...
May 22, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29781267/highly-regular-uniform-k-3-scf-6-mn-4-phosphors-facile-synthesis-microstructures-photo-luminescence-properties-and-application-in-led-devices
#2
Hong Ming, Shuifu Liu, Lili Liu, Jiaqing Peng, Junxiang Fu, Fu Du, Xinyu Ye
A new generation of red phosphors of complex fluoride matrices activated with Mn4+ , has gained a broad interest in getting high color rendering index (CRI), low correlated color temperature (CCT) of white light-emitting diodes(WLEDs). However, besides their instability towards moisture, the extremely irregular and nonuniform morphologies of these phosphors have limited their practical industry applications. In the present study, a novel type of K3 ScF6 :Mn4+ red phosphor with highly regular, uniform and high color purity was synthesized successfully via a facile two-step co-precipitation method under mild conditions...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29778626/factors-underlying-risk-taking-in-heroin-dependent-individuals-feedback-processing-and-environmental-contingencies
#3
Daniella M Saleme, Bruno Kluwe-Schiavon, Abdrabo Soliman, Błażej Misiak, Dorota Frydecka, Ahmed A Moustafa
Evidence suggests that factors influencing risk-taking include whether decisions are made based on emotions (affective systems) or cognitions (deliberative systems), the processing of feedback (e.g., deciding to attend a rehabilitation facility for opioid addiction treatment after an intervention held by a family member), and attention to environmental contingencies (e.g., considering the probability of an outcome such as the likelihood of contracting tetanus from a shared needle; or the gains and losses associated with a decision, such as the benefits and costs of taking drugs)...
May 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29777305/the-distribution-of-retinal-nerve-fiber-layer-thickness-and-associations-with-age-refraction-and-axial-length-the-gutenberg-health-study
#4
Esther M Hoffmann, Irene Schmidtmann, Angeliki Siouli, Alexander K Schuster, Manfred E Beutel, Norbert Pfeiffer, Julia Lamparter
PURPOSE: To evaluate the distribution of peripapillary retinal nerve fiber layer thickness as measured by optical coherence tomography and its associations with ocular parameters in a population-based setting. METHODS: In the population-based Gutenberg Health Study, 1974 subjects from the Mainz-Bingen region were scheduled for ophthalmologic examinations, including visual acuity, refraction, tonometry, biometry, and measurements of peripapillary retinal nerve fiber layer thickness (pRNFL) by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany)...
May 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29773458/outcomes-of-conventional-phacoemulsification-versus-femtosecond-laser-assisted-cataract-surgery-in-eyes-with-fuchs-endothelial-corneal-dystrophy
#5
Dagny C Zhu, Parth Shah, William J Feuer, Wei Shi, Ellen H Koo
PURPOSE: To compare the outcomes in eyes with Fuchs endothelial corneal dystrophy after standard phacoemulsification with those of femtosecond laser-assisted cataract surgery. SETTING: Bascom Palmer Eye Institute, Miami, Florida, USA. DESIGN: Retrospective case series. METHODS: Charts from patients diagnosed with Fuchs endothelial corneal dystrophy who had phacoemulsification cataract surgery at Bascom Palmer Eye Institute between January 1, 2014, and January 1, 2017, were reviewed...
May 15, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29769130/diagnostic-accuracy-of-low-dose-dual-source-cardiac-computed-tomography-as-compared-to-surgery-in-univentricular-heart-patients
#6
Narumol Chaosuwannakit, Pattarapong Makarawate
BACKGROUND: To evaluate the ability of low radiation dose dual-source computed tomography (DSCT) to depict the features of morphological univentricular heart and to define accuracy by comparing findings with surgery. METHODS: Low radiation dose dual-source cardiac computed tomography (CCT) of 33 cases of functional univentricular heart preliminary diagnosis by echocardiography compared with the results of surgery were retrospectively analyzed (aged 1 day to 4 years, median 5 months)...
May 16, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29768349/comparison-of-multiple-interventions-for-older-adults-with-alzheimer-disease-or-mild-cognitive-impairment-a-prisma-compliant-network-meta-analysis
#7
Jing-Hong Liang, Yong Xu, Lu Lin, Rui-Xia Jia, Hong-Bo Zhang, Lei Hang
BACKGROUND: The increasing prevalence of Alzheimer disease (AD) emphasizes the need for effective treatments. Both pharmacological therapies such as nutrition therapy (NT) and nonpharmacologic therapies including traditional treatment or personalized treatment (e.g., physical exercise, music therapy, computerized cognitive training) have been approved for the treatment of AD or mild cognitive impairment (MCI) in numerous areas. METHODS: The aim of this study was to compare 4 types of interventions, physical exercise (PE), music therapy (MT), computerized cognitive training (CCT), and NT, in older adults with mild to moderate AD or MCI and identify the most effective intervention for their cognitive function...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29764673/comparison-between-thromboelastography-and-conventional-coagulation-test-should-we-abandon-conventional-coagulation-tests-in-polytrauma-patients
#8
Jaume Tur Martínez, Patrizio Petrone, Alexander Axelrad, Corrado P Marini
INTRODUCTION: TEG provides an in-vivo assessment of viscoelastic clot strength in whole blood compared with CCT, which may not reflect the influence of platelets. The aim of this study was to compare TEG vs. CCT in trauma patients stratified by mechanism of injury (MOI) and pre-existing coagulation status. METHODS: A retrospective, observational study of 230 polytrauma patients admitted to a University Hospital Level 1 Trauma Center, with TEG and CCT on admission stratified by MOI: multiple trauma (MT), isolated traumatic brain injury (TBI) or MT+TBI...
May 12, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29760442/cross-ancestry-genome-wide-association-analysis-of-corneal-thickness-strengthens-link-between-complex-and-mendelian-eye-diseases
#9
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne E M Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline C W Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29755822/descemet-membrane-endothelial-keratoplasty-with-irregular-edged-graft-a-salvage-method-for-large-radial-graft-tears
#10
Mehmet Cüneyt Özmen, Nilay Dilekmen, Erdem Yüksel, Bahri Aydın, Fikret Akata
Large radial tears of donor Descemet membrane (DM) during the preparation of Descemet membrane endothelial keratoplasty (DMEK) grafts can make the trephination stage impossible because of small graft diameter. This results in irregular-edged grafts. In this study, we report two pseudophakic bullous keratopathy patients who underwent DMEK surgery with irregular-edged Descemet membrane (DM) grafts. Main outcome measures were preoperative and postoperative 1-, 3-, and 6-month best corrected visual acuity (BCVA), endothelial cell density (ECD) and central corneal thickness (CCT)...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750494/red-mn-4-doped-fluoride-phosphors-why-purity-matters
#11
Reinert Verstraete, Heleen Sijbom, Jonas J Joos, Katleen Korthout, Dirk Poelman, Christophe Detavernier, Philippe F Smet
Traditional light sources, e.g. incandescent and fluorescent lamps, are currently being replaced by white light-emitting diodes (wLEDs) because of their improved efficiency, prolonged lifetime and environmental friendliness. Much effort has recently been spent to the development of Mn4+ -doped fluoride phosphors which can enhance the color gamut in displays and improve the color rendering index (CRI), luminous efficacy of the radiation (LER) and correlated color temperature (CCT) of wLEDs used for lighting...
May 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29750123/visual-subfield-progression-in-glaucoma-subtypes
#12
Wei-Wen Su, Shian-Sen Hsieh, Shih-Tsung Cheng, Cheng-Wen Su, Wei-Chi Wu, Henry Shen-Lih Chen
Purpose: To investigate visual field progression pattern and factors associated with progression in patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and chronic angle-closure glaucoma (CACG). Methods: The raw data of the 30-2 Humphrey Field Analyzer from glaucoma patients with definite visual field progression were processed with pointwise linear regression (PLR) analysis. The rate of change of retinal threshold sensitivity in the ten glaucoma hemifield test (GHT) zones, the upper and the lower hemifields, and the whole field was evaluated and was correlated with patients' basic demographic data...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29745015/trivalent-rare-earth-activated-hexagonal-lanthanum-fluoride-laf-3-re-3-where-re-tb-sm-dy-and-tm-nanocrystals-synthesis-and-optical-properties
#13
Singh Kasturi, R Marikumar, Sivakumar Vaidyanathan
The LaF3 nanocrystals through a facile hydrothermal route with hexagonal structures have been synthesized via doping of trivalent rare earth (RE3+ ) ions - RE = Tb, Sm, Dy and Tm - with rod-like and perforated morphologies using NH4 F as fluorine precursor. Hexagonal phase formation was confirmed by powder X-ray diffraction. The crystalline sizes were calculated by the Scherrer equation where found to have an average crystalline size of 12 to 35 nm. The morphological studies of the nanocrystals were carried out by means of transmission electron microscopy (TEM)...
May 10, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29735743/the-substrate-specificity-of-eukaryotic-cytosolic-chaperonin-cct
#14
REVIEW
Keith R Willison
The cytosolic chaperonin CCT (chaperonin containing TCP-1) is an ATP-dependent double-ring protein machine mediating the folding of members of the eukaryotic cytoskeletal protein families. The actins and tubulins are obligate substrates of CCT because they are completely dependent on CCT activity to reach their native states. Genetic and proteomic analysis of the CCT interactome in the yeast Saccharomyces cerevisiae revealed a CCT network of approximately 300 genes and proteins involved in many fundamental biological processes...
June 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29721646/meta-analysis-of-the-effects-of-computerized-cognitive-training-on-executive-functions-a-cross-disciplinary-taxonomy-for-classifying-outcome-cognitive-factors
#15
REVIEW
Shannon L Webb, Vanessa Loh, Amit Lampit, Joel E Bateman, Damian P Birney
The growing prevalence of neurodegenerative disorders associated with aging and cognitive decline has generated increasing cross-disciplinary interest in non-pharmacological interventions, such as computerized cognitive training (CCT), which may prevent or slow cognitive decline. However, inconsistent findings across meta-analytic reviews in the field suggest a lack of cross-disciplinary consensus and on-going debate regarding the benefits of CCT. We posit that a contributing factor is the lack of a theoretically-based taxonomy of constructs and representative tasks typically used...
May 3, 2018: Neuropsychology Review
https://www.readbyqxmd.com/read/29718841/radiotherapy-alone-and-with-concurrent-chemotherapy-for-nasopharyngeal-carcinoma-a-retrospective-study
#16
Atsuto Katano, Wataru Takahashi, Hideomi Yamashita, Kentaro Yamamoto, Mizuo Ando, Masafumi Yoshida, Yuki Saito, Osamu Abe, Keiichi Nakagawa
We sought to evaluate clinical outcomes and toxicities of radiation therapy (RT) alone compared to RT with concurrent chemotherapy (CCT) for nasopharyngeal carcinoma (NPC) treatment.We conducted a retrospective review of consecutive patients with biopsy-proven nonmetastatic NPC who underwent RT at our institution. From May 2001 to April 2015; 62 newly diagnosed NPC patients were treated with three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) with or without CCT. The patients were classified as follows: 8% stage I, 15% stage II, 32% stage III, and 45% stage IVA/IVB...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29715490/an-antidepressant-related-pharmacological-signature-for-positive-allosteric-modulators-of-%C3%AE-2-3-containing-gaba-a-receptors
#17
K R Methuku, X Li, R Cerne, S D Gleason, J M Schkeryantz, V V N P B Tiruveedhula, L K Golani, G Li, M M Poe, Md T Rahman, J M Cook, J L Fisher, J M Witkin
Data from transgenic animals and novel pharmacological agents has realigned scientific scrutiny on the therapeutic potential of positive allosteric modulators (PAMs) of α2/3-containing GABAA receptors. Evidence for analgesic, anticonvulsant, and anxiolytic activity of α2/3-selective PAMs has been presented along with the clinical potential for a milder motor-impacting profile compared to non-selective GABAA receptor PAMs. A new series of α2/3-selective PAMs was recently introduced which has anxiolytic and anticonvulsant activity in rodent models...
April 28, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29715058/corneal-endothelial-changes-in-beh%C3%A3-et-s-patients-with-inactive-ocular-involvement
#18
Cem Cankaya, Tongabay Cumurcu, Abuzer Gunduz, Ilknur Fırat
PURPOSE: To evaluate alterations in the corneal endothelial layer in Behçet's disease (BD) with inactive ocular involvement using specular microscopy. MATERIALS AND METHODS: Thirty-three eyes of 33 BD patients who had at least one anterior segment involvement and no active inflammation in the last 3 months were included in the study (group 1). Twenty-seven of the thirty-three BD patients had an anterior uveitis attack and six of them had a panuveitis (both anterior and posterior involvement) attack...
May 1, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29705114/review-of-interventions-and-radiation-exposure-from-chest-computed-tomography-in-children-with-blunt-trauma
#19
Victor Hsiao, Genevieve Santillanes, Daniel Malek, Ilene Claudius
OBJECTIVE: To determine the radiation risk to a child undergoing trauma evaluation with chest computed tomography (CCT) for every clinically actionable injury identified. STUDY DESIGN: This observational, cross-sectional study included all blunt trauma patients under 18 years of age undergoing CCT in a single urban emergency department. Via a retrospective chart review, therapeutic interventions done exclusively for chest injuries identified on CCT scan were identified...
April 25, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29703045/a-feasibility-and-safety-study-of-concurrent-chemotherapy-based-on-genetic-testing-in-patients-with-high-risk-salivary-gland-tumors-preliminary-results
#20
Rongrong Li, Shengjin Dou, Min Ruan, Chenping Zhang, Guopei Zhu
BACKGROUND: This prospective study was conducted to evaluate the feasibility and safety of customized chemotherapy regimens based on the gene characteristics of salivary gland tumors. METHODS: Patients were enrolled with histologically confirmed intermediate or high grade, stage T3-4, N1-3 disease, and T1-2, N0 patients with a close (≤1 mm) or microscopically positive surgical margin were also enrolled in the study. All patients received radical surgery and postoperative concurrent chemoradiotherapy...
April 2018: Medicine (Baltimore)
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