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https://www.readbyqxmd.com/read/28929241/assessment-of-peripapillary-choroidal-thickness-in-primary-open-angle-glaucoma-patients-with-choroidal-vascular-prominence
#1
Yong Ju Song, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate the relationship between peripapillary choroidal thickness (PCT) and choroidal vascular prominence (CVP) colocalized with retinal nerve fiber layer (RNFL) defect in primary open-angle glaucoma (POAG) eyes and to evaluate the relationship between PCT and POAG severity. METHODS: In this cross-sectional comparative study, 29 POAG patients with CVP on RNFL imaging (Group A), 70 POAG patients without CVP (Group B) and 63 healthy controls (Group C) were examined...
September 19, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28928940/comparison-of-color-discrimination-in-chronic-heavy-smokers-and-healthy-subjects
#2
Thiago Monteiro de Paiva Fernandes, Natanael Antonio Dos Santos
Background: Cigarette smoke is probably the most significant source of exposure to toxic chemicals for humans, involving health-damaging components, such as nicotine, hydrogen cyanide and formaldehyde. The aim of the present study was to assess the influence of chronic heavy smoking on color discrimination (CD). Methods: All subjects were free of any neuropsychiatric disorder, identifiable ocular disease and had normal acuity. No abnormalities were detected in the fundoscopic examination and in the optical coherence tomography exam...
2017: F1000Research
https://www.readbyqxmd.com/read/28926231/resonance-emission-enhancement-ree-for-narrow-band-red-emitting-a2gef6-mn-4-a-na-k-rb-cs-phosphors-synthesized-via-a-precipitation-cation-exchange-route
#3
Hongzhou Lian, Qingming Huang, Yeqing Chen, Kai Li, Sisi Liang, Mengmeng Shang, Manman Liu, Jun Lin
Narrow band red-emitting A2GeF6:Mn(4+) (A = Na, K, Rb, Cs) phosphors were prepared through a two-step precipitation-cation exchange route using a K2MnF6 precursor as the Mn(4+) source. The phase purity, morphology, and constituent were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectric spectroscopy (XPS), and electron paramagnetic resonance (EPR) examination. Optical properties were investigated by photoluminescence spectra (PL and PLE) and high-resolution PL. A temperature-dependent PL examination was performed to investigate the electron-phonon coupling emission mechanism of Mn(4+) in these alkali fluorogermanates...
September 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28922780/use-of-alternative-medicine-for-cancer-and-its-impact-on-survival
#4
Skyler B Johnson, Henry S Park, Cary P Gross, James B Yu
There is limited available information on patterns of utilization and efficacy of alternative medicine (AM) for patients with cancer. We identified 281 patients with nonmetastatic breast, prostate, lung, or colorectal cancer who chose AM, administered as sole anticancer treatment among patients who did not receive conventional cancer treatment (CCT), defined as chemotherapy, radiotherapy, surgery, and/or hormone therapy. Independent covariates on multivariable logistic regression associated with increased likelihood of AM use included breast or lung cancer, higher socioeconomic status, Intermountain West or Pacific location, stage II or III disease, and low comorbidity score...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922158/tailored-and-adaptive-computerized-cognitive-training-in-older-adults-at-risk-for-dementia-a-randomized-controlled-trial
#5
Alex Bahar-Fuchs, Shannon Webb, Lauren Bartsch, Linda Clare, George Rebok, Nicolas Cherbuin, Kaarin J Anstey
BACKGROUND: Computerized Cognitive Training (CCT) has been shown to improve cognitive function in older adults with mild cognitive impairment (MCI) or mood-related neuropsychiatric symptoms (MrNPS), but many questions remain unresolved. OBJECTIVE: To evaluate the extent to which CCT benefits older adults with both MCI and MrNPS, and its effects on meta-cognitive and non-cognitive outcomes, as well as establish whether adapting difficulty levels and tailoring to individuals' profile is superior to generic training...
September 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28916922/evaluation-of-zmcct-haplotypes-for-genetic-improvement-of-maize-hybrids
#6
Yipu Li, Lixiu Tong, Lele Deng, Qiyu Liu, Yuexian Xing, Chao Wang, Baoshen Liu, Xiaohong Yang, Mingliang Xu
The elite ZmCCT haplotypes which have no transposable element in the promoter could enhance maize resistance to Gibberella stalk rot and improve yield-related traits, while having no or mild impact on flowering time. Therefore, they are expected to have great value in future maize breeding programs. A CCT domain-containing gene, ZmCCT, is involved in both photoperiod response and stalk rot resistance in maize. At least 15 haplotypes are present at the ZmCCT locus in maize germplasm, whereas only three of them are found in Chinese commercial maize hybrids...
September 15, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28915208/appropriate-use-criteria-for-cardiac-computed-tomography-impact-on-diagnostic-utility
#7
Karan Bami, Manuja Premaratne, Jasmine Lamba, Yeung Yam, Alomgir Hossain, Marissa Keenan, Tony Haddad, Saipriya Anand, Ian G Burwash, Terrence D Ruddy, Girish Dwivedi, Benjamin J W Chow
BACKGROUND: Appropriate Use Criteria (AUC) guidelines for cardiac computed tomography (CCT) were developed to limit testing to reasonable clinical settings. However, significant testing is still done for inappropriate indications. This study investigates the impact of AUC on evaluability of CCT to determine if inappropriate tests result in a greater proportion of nondiagnostic results. METHODS: Investigators reviewed the medical records of 2417 consecutive patients who underwent CCT at the University of Ottawa Heart Institute...
September 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28913507/keratoconus-diagnosis-using-corvis-st-measured-biomechanical-parameters
#8
Roghiyeh Elham, Ebrahim Jafarzadehpur, Hassan Hashemi, Kazem Amanzadeh, Fereshteh Shokrollahzadeh, Abbasali Yekta, Mehdi Khabazkhoob
PURPOSE: To assess the diagnostic power of the Corneal Visualization Scheimpflug Technology (Corvis ST) provided corneal biomechanical parameters in keratoconic corneas. METHODS: The following biomechanical parameters of 48 keratoconic eyes were compared with the corresponding ones in 50 normal eyes: time of the first applanation and time from start to the second applanation [applanation-1 time (A1T) and applanation-2 time (A2T)], time of the highest corneal displacement [highest concavity time (HCT)], magnitude of the displacement [highest concavity deformation amplitude (HCDA)], the length of the flattened segment in the applanations [first applanation length (A1L) and second applanation length (A2L)], velocity of corneal movement during applanations [applanation-1 velocity (A1V) and applanation-2 velocity (A2V)], distance between bending points of the cornea at the highest concavity [highest concavity peak distance (HCPD)], central concave curvature at the highest concavity [highest concavity radius (HCR)]...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28912968/bimanual-microincision-cataract-surgery-versus-coaxial-microincision-cataract-surgery-a-meta-analysis-of-randomized-controlled-trials-and-cohort-studies
#9
Chenxi Fu, Naipin Chu, Xiaoning Yu, Ke Yao
PURPOSE: This meta-analysis was conducted to compare the intraoperative and postoperative outcomes of bimanual microincision cataract surgery (B-MICS) and coaxial microincision cataract surgery (C-MICS). METHODS: Three databases were searched for papers that compared B-MICS and C-MICS from inception to June 2016. The following intraoperative and postoperative outcomes were included in the final meta-analysis: ultrasound time (UST), effective phacoemulsification time (EPT), balanced salt solution use (BSS use), mean surgery time, best-corrected visual acuity (BCVA), central corneal thickness (CCT), and increased CCT...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28906489/disrupting-cct-%C3%AE-%C3%A2-%C3%A2-%C3%AE-tubulin-selectively-kills-cct-%C3%AE-overexpressed-cancer-cells-through-mapks-activation
#10
Yan-Jin Liu, Vathan Kumar, Yuan-Feng Lin, Po-Huang Liang
We have previously demonstrated the ability of I-Trp to disrupt the protein-protein interaction of β-tubulin with chaperonin-containing TCP-1β (CCT-β). This caused more severe apoptosis in multidrug-resistant MES-SA/Dx5, compared to MES-SA, due to its higher CCT-β overexpression. In this study, we screened a panel of cancer cell lines, finding CCT-β overexpression in the triple-negative breast cancer cell line MDA-MB-231, colorectal cancer cell lines Colo205 and HCT116, and a gastric cancer cell line MKN-45...
September 14, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28903051/features-of-the-chaperone-cellular-network-revealed-through-systematic-interaction-mapping
#11
Kamran Rizzolo, Jennifer Huen, Ashwani Kumar, Sadhna Phanse, James Vlasblom, Yoshito Kakihara, Hussein A Zeineddine, Zoran Minic, Jamie Snider, Wen Wang, Carles Pons, Thiago V Seraphim, Edgar Erik Boczek, Simon Alberti, Michael Costanzo, Chad L Myers, Igor Stagljar, Charles Boone, Mohan Babu, Walid A Houry
A comprehensive view of molecular chaperone function in the cell was obtained through a systematic global integrative network approach based on physical (protein-protein) and genetic (gene-gene or epistatic) interaction mapping. This allowed us to decipher interactions involving all core chaperones (67) and cochaperones (15) of Saccharomyces cerevisiae. Our analysis revealed the presence of a large chaperone functional supercomplex, which we named the naturally joined (NAJ) chaperone complex, encompassing Hsp40, Hsp70, Hsp90, AAA+, CCT, and small Hsps...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28902884/development-of-est-ssr-markers-in-flowering-chinese-cabbage-brassica-campestris-l-ssp-chinensis-var-utilis-tsen-et-lee-based-on-de-novo-transcriptomic-assemblies
#12
Jingfang Chen, Ronghua Li, Yanshi Xia, Guihua Bai, Peiguo Guo, Zhiliang Wang, Hua Zhang, Kadambot H M Siddique
Flowering Chinese cabbage is one of the most important vegetable crops in southern China. Genetic improvement of various agronomic traits in this crop is underway to meet high market demand in the region, but the progress is hampered by limited number of molecular markers available in this crop. This study aimed to develop EST-SSR markers from transcriptome sequences generated by next-generation sequencing. RNA-seq of eight cabbage samples identified 48,975 unigenes. Of these unigenes, 23,267 were annotated in 56 gene ontology (GO) categories, 6,033 were mapped to 131 KEGG pathways, and 7,825 were assigned to clusters of orthologous groups (COGs)...
2017: PloS One
https://www.readbyqxmd.com/read/28898873/two-year-outcomes-of-a-treat-and-extend-regimen-using-intravitreal-aflibercept-injections-for-typical-age-related-macular-degeneration
#13
Arisa Ito, Hidetaka Matsumoto, Masahiro Morimoto, Kensuke Mimura, Hideo Akiyama
PURPOSE: The aim of this study was to evaluate the efficacy of a treat-and-extend (TAE) regimen using intravitreal injection of aflibercept (IVA) for typical age-related macular degeneration (tAMD). METHODS: We retrospectively studied 61 treatment-naïve eyes with tAMD. Best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), number of injections, and complications during 2 years were evaluated. RESULTS: BCVA significantly improved by on average 0...
September 13, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28884654/controlled-clinical-trials-of-cell-therapy-in-stroke-meta-analysis-at-six-months-after-treatment
#14
Olivier Detante, Anaïck Moisan, Marc Hommel, Assia Jaillard
Background Cell therapy is promising in experimental studies and has been assessed only in a few studies on humans. Aims To evaluate the effect of cell therapy in humans. Methods We included clinical trials with a control group that reported safety and efficacy six months following treatment. Quality was evaluated and clinical scales data were extracted. Quantitative analysis was based on the standardized means difference (SMD). Among 28 trials published from 1995 to 2016, nine studies (194 patients; 191 controls) were eligible...
October 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28879667/clinical-biomicroscopy-and-retinoscopy-findings-of-keratoconus-in-a-middle-eastern-population
#15
Mohammad Naderan, Ali Jahanrad, Mahgol Farjadnia
BACKGROUND: The present work was conducted to investigate the prevalence of clinical biomicroscopy and retinoscopy findings of corneas with keratoconus (KC) at first presentation and their relationship with disease severity. METHOD: In a prospective cross-sectional study, 371 consecutive KC patients were examined by slitlamp biomicroscopy and retinoscopy at the time of diagnosis. This research evaluates the prevalence of clinical findings such as a corneal protrusion, Vogt's striae, Fleischer's ring, Munson's sign, Rizzuti's sign, corneal scars, as well as any additional KC signs such as prominent nerve fibres, scissoring reflex and Charleaux 'oil droplet' sign on retinoscopy...
September 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28879527/diabetes-and-pachymetry-changes-in-pregnancy
#16
Florence Santiagu, Azam Bakhtiari, Tajunisah Iqbal, Nurliza Khaliddin, Van C Lansingh, Visvaraja Subrayan
BACKGROUND: Purpose of this study is to evaluate changes in the central corneal thickness (CCT) in patients during the third trimester and postpartum phases of normal pregnancy, pregestational diabetes mellitus (DM), and gestational diabetes mellitus (GDM). METHODS: This was a prospective study. Patients that fulfilled the inclusion criteria were recruited from the obstetric clinic. They were grouped into normal pregnancy, pregestational DM, and GDM. Ophthalmic assessment and haematological investigations were done during the third trimester (after 28 weeks of gestation) and in the postpartum phase (6 weeks postpartum)...
September 6, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28878336/effect-of-gnrhr-polymorphisms-on-in-vitro-fertilization-and-embryo-transfer-in-patients-with-polycystic-ovary-syndrome
#17
Wei-Yan Chen, Yan-Qiu Du, Xia Guan, Hong-Yun Zhang, Ting Liu
We investigated the relationship between gonadotropin-releasing hormone receptor (GnRHR) gene polymorphisms and outcome of patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET). PCOS patients undergoing IVF-ET were selected, and infertile patients due to dysfunctional oviducts served as controls. GnRHR gene polymorphisms were detected using the polymerase chain reaction-restriction fragment length polymorphism assay. Gene-gene interaction and linkage disequilibrium tests were performed using the SHEsis software...
September 7, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28876994/encouraging-critical-clinical-thinking-cct-skills-in-first-year-veterinary-students
#18
Duncan C Ferguson, Leslie Klis McNeil, David J Schaeffe, Eric M Mills
First-year didactic course instructors at the University of Illinois College of Veterinary Medicine leverage earlier clinical rotation experiences with weekly "Clinical Correlations" exercises to provide early exposure to critical clinical thinking (CCT). This study evaluated the efficacy of individual and paired group exercises on CCT development. Before and after instruction, the Cornell Critical Thinking Test (Level Z) (CCTTZ) was administered. Based on the hypothesis that students with higher scores would coach lower-scoring colleagues during group exercises, heterogeneous groups with similar mean scores were established for the year...
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28874879/violet-laser-diode-enables-lighting-communication
#19
Yu-Chieh Chi, Yu-Fang Huang, Tsai-Chen Wu, Cheng-Ting Tsai, Li-Yin Chen, Hao-Chung Kuo, Gong-Ru Lin
Violet laser diode (VLD) based white-light source with high color rendering index (CRI) for lighting communication is implemented by covering with Y3Al5O12:Ce(3+) (YAG:Ce) or Lu3Al5O12:Ce(3+)/CaAlSiN3:Eu(2+) (LuAG:Ce/CASN:Eu) phosphorous diffuser plates. After passing the beam of VLD biased at 70 mA (~2I th ) through the YAG:Ce phosphorous diffuser, a daylight with a correlated color temperature (CCT) of 5068 K and a CRI of 65 is acquired to provide a forward error correction (FEC) certified data rate of 4...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28867331/reference-ranges-for-serum-s100b-neuroprotein-specific-to-infants-under-four-months-of-age
#20
Jeanne Simon-Pimmel, Fleur Lorton, Damien Masson, Damien Bouvier, Matthieu Hanf, Christèle Gras-Le Guen
BACKGROUND: Minor head traumatisms are a common reason for consultation in paediatric emergency departments. The diagnosis of traumatic brain injuries involves performing a cranial computed tomography (CCT), associated with a risk of cancer due to the radiation. The serum S100B is an effective biomarker used to reduce reliance on CCT. While reference ranges have been determined, the limited number of cases regarding infants less than 4months of age has not allowed this biomarker to be used with this age group...
September 1, 2017: Clinical Biochemistry
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