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https://www.readbyqxmd.com/read/28731879/peripheral-endothelial-cell-count-is-a-predictor-of-disease-severity-in-advanced-fuchs-endothelial-corneal-dystrophy
#1
Zeba A Syed, Jennifer A Tran, Ula V Jurkunas
PURPOSE: In advanced Fuchs endothelial corneal dystrophy (FECD), central endothelial changes do not correlate with disease severity. The peripheral endothelial cell count (ECC) has not been studied as a marker of FECD severity. The goal of this study was to determine the relationship between the peripheral ECC and known clinical markers of FECD in advanced cases. METHODS: Patients with FECD examined between January 1, 2013, and September 1, 2016, by 1 cornea specialist were identified...
July 19, 2017: Cornea
https://www.readbyqxmd.com/read/28731878/correlation-of-corneal-biomechanical-stiffness-with-refractive-error-and-ocular-biometry-in-a-pediatric-population
#2
Jyoti Matalia, Mathew Francis, Pooja Gogri, Pratibha Panmand, Himanshu Matalia, Abhijit Sinha Roy
PURPOSE: To assess the correlation between corneal biomechanical stiffness and refractive error (RE) in the pediatric population. METHODS: A total of 733 pediatric eyes were included in the study retrospectively. All eyes underwent corneal tomography (Pentacam), RE assessment, and air-puff deformation (Corvis-ST). Waveform analyses of deformation provided corneal stiffness (CS) and extraocular tissue stiffness (EOS). Eyes were subgrouped into emmetropia [manifest refraction spherical equivalent (MRSE) ∼ 0 D], hyperopia (MRSE > 0 D), myopia I (MRSE between 0 D and -3 D), myopia II (MRSE between -3 D and -6 D), and myopia III (MRSE greater than -6 D) for multivariate analyses...
July 19, 2017: Cornea
https://www.readbyqxmd.com/read/28726492/does-cognition-specific-computer-training-have-better-clinical-outcomes-than-non-specific-computer-training-a-single-blind-randomized-controlled-trial
#3
Ji-Hyuk Park, Jin-Hyuck Park
OBJECTIVE: The purpose of this study was to investigate differences between non-specific computer training (NCT) and cognition-specific computer training (CCT). DESIGN: Randomized controlled experimental study. SETTING: Local community welfare center. SUBJECTS: A total of 78 subjects with mild cognitive impairment (MCI) were randomly assigned to the NCT ( n = 39) or CCT group ( n = 39). INTERVENTION: The NCT group underwent NCT using Nintendo Wii for improving functional performance, while the CCT group underwent CCT using CoTras for improving function of the cognitive domain specifically...
July 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28725900/luminescence-properties-and-warm-white-led-application-of-a-ternary-alkaline-fluoride-red-phosphor-k2naalf6-mn-4-%C3%A2
#4
L Y Wang, E H Song, T T Deng, Y Y Zhou, Z F Liao, W R Zhao, B Zhou, Q Y Zhang
Herein, a Mn(4+) ion doped complex ternary-alkaline fluoride red phosphor K2NaAlF6:Mn(4+) has been synthesized through a facile two-step co-precipitation method at room temperature. The crystal structure, morphological properties and influence of the dopant concentration, temperature and humidity on luminescence properties as well as the performance of the as-synthesized phosphor used in white light emitting diodes (WLEDs) were investigated carefully. Intense absorption in the blue region (∼460 nm) and bright narrow-band red emission (∼630 nm) with high color purity were observed from this resultant powder...
July 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28722229/a-transposon-directed-epigenetic-change-in-zmcct-underlies-quantitative-resistance-to-gibberella-stalk-rot-in-maize
#5
Chao Wang, Qin Yang, Weixiang Wang, Yipu Li, Yanling Guo, Dongfeng Zhang, Xuena Ma, Wei Song, Jiuran Zhao, Mingliang Xu
A major resistance quantitative trait locus, qRfg1, significantly enhances maize resistance to Gibberella stalk rot, a devastating disease caused by Fusarium graminearum. However, the underlying molecular mechanism remains unknown. We adopted a map-based cloning approach to identify the resistance gene at qRfg1 and examined the dynamic epigenetic changes during qRfg1-mediated maize resistance to the disease. A CCT domain-containing gene, ZmCCT, is the causal gene at the qRfg1 locus and a polymorphic CACTA-like transposable element (TE1) c...
July 19, 2017: New Phytologist
https://www.readbyqxmd.com/read/28721008/effect-of-age-sex-and-refractive-errors-on-central-corneal-thickness-measured-by-oculus-pentacam-%C3%A2
#6
Nauman Hashmani, Sharif Hashmani, Azfar N Hanfi, Misbah Ayub, Choudhry M Saad, Hina Rajani, Marium G Muhammad, Misbahul Aziz
BACKGROUND: Central corneal thickness (CCT) can be used to assess the corneal physiological condition as well as the pathological changes associated with ocular diseases. It has an influence on the measurement of intraocular pressure and is being used as a screening tool for refractive surgery candidates. The aim of this study was to determine the median CCT among normal Pakistani population and to correlate CCT with age, sex, and refractive errors. METHODS: We conducted a retrospective analysis of 5,171 healthy eyes in 2,598 patients who came to Hashmanis Hospital, Karachi, Pakistan...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28718037/cost-effectiveness-of-surveillance-for-distant-recurrence-in-extremity-soft-tissue-sarcoma
#7
Trevor J Royce, Rinaa S Punglia, Aileen B Chen, Sagar A Patel, Katherine A Thornton, Chandrajit P Raut, Elizabeth H Baldini
BACKGROUND: Optimal distant recurrence (DR) surveillance strategies for extremity soft tissue sarcoma (STS) are unknown. We performed a cost-effectiveness analysis of different imaging modalities performed at guideline-specified intervals. METHODS: We developed a Markov model simulating lifetime outcomes for 54-year-old patients after definitive treatment for American Joint Committee on Cancer stage II-III extremity STS using four surveillance strategies: watchful waiting (WW), chest X-ray (CXR), chest computed tomography (CCT), and positron emission tomography-computed tomography (PET/CT)...
July 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28713324/color-vision-losses-in-autism-spectrum-disorders
#8
Elaine C Zachi, Thiago L Costa, Mirella T S Barboni, Marcelo F Costa, Daniela M O Bonci, Dora F Ventura
Autism spectrum disorders (ASDs) are neurodevelopmental conditions characterized by impairments in social/communication abilities and restricted behaviors. The present study aims to examine color vision discrimination in ASD children and adolescents without intellectual disability. The participants were also subdivided in order to compare color vision thresholds of autistic participants and those who achieved diagnostic criteria for Asperger Syndrome (AS). Nine subjects with autism, 11 participants with AS and 36 typically developing children and adolescents participated in the study...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28710485/alternative-functions-of-hd1-in-repressing-or-promoting-heading-are-determined-by-ghd7-status-under-long-day-conditions
#9
Zhanyi Zhang, Wei Hu, Guojing Shen, Haiyang Liu, Yong Hu, Xiangchun Zhou, Touming Liu, Yongzhong Xing
Previous studies suggested that Hd1 promoted heading under short-day conditions (SD) and delayed heading under long-day conditions (LD). However in this study, Hd1 was demonstrated to consistently promote heading date in Zhenshan 97 (ZS97) background by upregulating Ehd1, Hd3a and RFT1 expression under both SD and LD. While the high photoperiod sensitivity of Hd1 was observed in Minghui 63 (MH63) background, with heading being suppressed in LD but promoted in SD. Comparative analysis of two sets of near isogenic lines of Hd1 in MH63 and ZS97 backgrounds indicated that the alternative functions of Hd1 in promoting or suppressing heading under LD are dependent on the previously cloned flowering repressor gene Ghd7...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704709/protective-role-of-surface-toll-like-receptor-9-expressing-neutrophils-in-local-inflammation-during-systemic-inflammatory-response-syndrome-in-mice
#10
Xiuping Meng, Wei Sun, Yunjia Ren, Yue Xiao, Peiyan Zhao, Wenting Lu, Li Hua, Luowei Wang, Liying Wang, Yongli Yu
Clinically, systemic inflammatory response syndrome (SIRS) occurs after serious trauma or sepsis. In sepsis, neutrophils are the major effector cells responsible for eliminating pathogens. However, the role of neutrophils in development of SIRS, especially in local inflammatory area, is controversial. In this study, we established a SIRS mouse model characterized with cytokine-mediated lethal shock by intraperitoneal injection of oligodexynucleotides containing CpG motifs (CpG ODN) in D-galactosamine (D-GalN) sensitized mice based on our previous work and found that abundant neutrophils were rapidly recruited into the peritoneal cavity, where some neutrophils expressed surface TLR9 (sTLR9), defined as sTLR9(+) neutrophils...
July 10, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28699324/corneal-endothelial-cell-loss-and-corneal-biomechanical-characteristics-after-two-step-sequential-or-combined-phaco-vitrectomy-surgery-for-idiopathic-epiretinal-membrane
#11
Hassan Hamoudi, Ulrik Correll Christensen, Morten La Cour
PURPOSE: To assess the impact of sequential and combined surgery [cataract surgery and 23-gauge pars plana vitrectomy (PPV) with peeling] on corneal endothelium cell density (CED) and corneal biomechanical characteristics. METHODS: Phakic eyes with epiretinal membrane (ERM) were prospectively allocated to (i) cataract surgery and subsequent PPV (CAT group), (ii) PPV and subsequent cataract surgery (VIT group) or (iii) phacovitrectomy (COMBI group). Eyes were examined at baseline, 1 month after each surgery, and at 3 and 12 months follow-up...
August 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28693686/the-correlation-of-indices-in-r-teg-with-intra-operative-blood-loss-in-neurosurgical-patients
#12
Zhang Xue, Yu Xuerong, Huang Yuguang
Objective Intra-operative coagulopathy has a close relationship with blood loss and the prognosis of patients. Rapid-thrombelastography (r-TEG) is a comprehensive assessment of coagulation abnormalities and also an effective way for constructing blood transfusion. This study attempts to investigate the correlation of r-TEG indices with intra-operative hemorrhage.Methods Patients who underwent transphenoidal hypophysectomy and craniotomy from January 15 to April 30, 2013 in Peking Union Medical College hospital were recruited...
June 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28693437/effects-of-computerized-cognitive-training-on-neuroimaging-outcomes-in-older-adults-a-systematic-review
#13
Lisanne F Ten Brinke, Jennifer C Davis, Cindy K Barha, Teresa Liu-Ambrose
BACKGROUND: Worldwide, the population is aging and the number of individuals diagnosed with dementia is rising rapidly. Currently, there are no effective pharmaceutical cures. Hence, identifying lifestyle approaches that may prevent, delay, or treat cognitive impairment and dementia in older adults is becoming increasingly important. Computerized Cognitive Training (CCT) is a promising strategy to combat cognitive decline. Yet, the underlying mechanisms of the effect of CCT on cognition remain poorly understood...
July 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28681443/evaluation-of-the-congenital-supravalvular-aortic-stenosis-by-different-imaging-modalities
#14
Ahmet Guner, Nuri Havan, Sabahattin Gunduz, Taylan Akgun, Busra Guvendi, Gokhan Kahveci
A 36-year-old female was admitted to hospital exhibiting chest pain, dyspnea, and a heart murmur on the right upper sternal border, radiating to both carotid arteries. The blood pressure of the patient's right arm exceeded the pressure in the left by 25 mm Hg (Coanda effect). In spite of laboratory results that did not fall outside the expected range, the left ventricle was revealed to be hypertrophic following electrocardiography. Transthoracic echocardiography revealed a severe supravalvular aortic stenosis (SVAS) with a peak Doppler velocity of 6...
July 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/28676862/use-of-brilliant-blue-g-in-descemet-s-membrane-endothelial-keratoplasty
#15
Takahiko Hayashi, Kentaro Yuda, Itaru Oyakawa, Naoko Kato
Vital staining of the endothelial graft is essential during Descemet's membrane endothelial keratoplasty (DMEK) to ensure surgical success. DMEK surgeons worldwide commonly use trypan blue (TB) to this end. However, TB may exert toxic effects on both the cornea and retina. Recently, Brilliant Blue G (BBG) has become recognized as an alternative stain for use during vitreoretinal surgery; BBG is associated with lower levels of toxicity. We retrospectively analyzed the utility of BBG staining during DMEK. We used 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28674859/comparison-of-central-corneal-thickness-and-endothelial-cell-measurements-by-scheimpflug-camera-system-and-two-noncontact-specular-microscopes
#16
Irmak Karaca, Suzan Guven Yilmaz, Melis Palamar, Halil Ates
PURPOSE: To investigate the correlation of Scheimpflug camera system and two noncontact specular microscopes in terms of central corneal thickness (CCT) and corneal endothelial cell morphology measurements. METHODS: One hundred eyes of 50 healthy subjects were examined by Pentacam Scheimpflug Analyzer, CEM-530 (Nidek Co, Ltd, Gamagori, Japan) and CellChek XL (Konan Medical, California, USA) via fully automated image analysis with no corrections made. Measurement differences and agreement between instruments were determined by intraclass correlation analysis...
July 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28674660/maternal-alcohol-consumption-during-pregnancy-and-child-s-cognitive-performance-at-6-8-years-of-age-in-rural-burkina-faso-an-observational-study
#17
Anselme Simeon Sanou, Abdoulaye Hama Diallo, Penny Holding, Victoria Nankabirwa, Ingunn Marie S Engebretsen, Grace Ndeezi, James K Tumwine, Nicolas Meda, Thorkild Tylleskar, Esperance Kashala-Abotnes
BACKGROUND: In Burkina Faso, it is not uncommon for mothers to drink alcohol, even during pregnancy. We aimed to study the association between maternal alcohol consumption during pregnancy and the child's cognitive performance using the Kaufman Assessment Battery for Children, 2nd edition (KABC-II) and the Children's Category Test Level 1 (CCT-1) in rural Burkina Faso. METHODS: We conducted a follow-up study of a community cluster-randomised Exclusive breastfeeding trial, and re-enrolled the children in rural Burkina Faso...
2017: PeerJ
https://www.readbyqxmd.com/read/28669041/two-year-results-of-a-treat-and-extend-regimen-with-aflibercept-for-polypoidal-choroidal-vasculopathy
#18
Masahiro Morimoto, Hidetaka Matsumoto, Kensuke Mimura, Hideo Akiyama
PURPOSE: To evaluate the effects of aflibercept therapy using a treat-and-extend regimen on treatment-naïve polypoidal choroidal vasculopathy (PCV). METHODS: In a retrospective interventional case series of 58 eyes of 58 patients with PCV, we assessed best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), and number of injections for 2 years. Polypoidal lesions were also evaluated before treatment and after the loading phase by indocyanine green angiography...
July 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28667801/a-study-of-selected-factors-affecting-efficacy-of-compost-tea-against-several-fungal-pathogens-of-potato
#19
W K Mengesha, W M Gill, S M Powell, K J Evans, K M Barry
AIM: To investigate selected factors of two non-aerated compost teas and mechanisms that influence the restriction of several fungal potato pathogens. METHODS AND RESULTS: Two non-aerated compost teas (NCTs, commercial compost, CCT; vineyard compost, VCT) were tested for their ability to suppress potato pathogens. The VCT was more suppressive than CCT to mycelial growth of A. solani and R. solani isolate 299, but not for R. solani isolate 422. Metagenomic studies of microbial diversity revealed that the CCT had higher fungal and bacterial diversity and richness than the VCT...
July 1, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28667581/intracameral-dexamethasone-injection-as-adjuvant-therapy-in-endothelial-immune-reaction-after-penetrating-and-posterior-lamellar-keratoplasty-a-retrospective-clinical-observation
#20
Miltiadis Fiorentzis, Arne Viestenz, Anja Viestenz, Berthold Seitz
INTRODUCTION: The aim of this observational study is to evaluate the effectiveness of an adjuvant intracameral corticosteroid injection (ICI) in cases of severe endothelial immune reaction (SEIR) (anterior chamber cells and flare, retrocorneal precipitates, Descemet's folds, and corneal edema) after penetrating keratoplasty and posterior lamellar keratoplasty. METHODS: In this retrospective study, 24 subjects treated between November 2011 and September 2014 were divided into two groups...
June 30, 2017: Advances in Therapy
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