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https://www.readbyqxmd.com/read/29345010/genetic-variation-in-the-shape-of-cold-survival-curves-in-a-single-fly-population-suggests-potential-for-selection-from-climate-variability
#1
Nicholas M Teets, Daniel A Hahn
Temperature variation is one of the primary challenges facing ectotherms, and the ability to tolerate a range of thermal environments is critical for setting current and future species distributions. Low temperature is particularly challenging for ectotherms because winter conditions have strong latitudinal and temporal variation. Lower lethal temperature (LLT) is a common metric of cold tolerance used in studies of local adaptation and plasticity. Comparisons of LLT across groups typically assume parallel S-shaped survival curves, but genetic variation in the shape of survival vs...
January 18, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29340867/photoluminescent-and-thermoluminescent-studies-of-dy3-and-eu3-doped-y2o3-phosphors
#2
Tarkeshwari Verma, Sadhana Agrawal
Eu3+ doped and Dy3+ codoped yttrium oxide (Y2O3) phosphors have been prepared using solid-state reaction technique (SSR). The prepared phosphors were characterized by X-ray diffractometer (XRD), energy dispersive X-ray (EDX) spectroscopy, scanning electron microscopy (SEM) and Fourier transforms infrared spectroscopy (FTIR) techniques. Photoluminescence (PL) and Thermoluminescence (TL) properties were studied in detail. PL emission spectra were recorded for prepared phosphors under excitation wavelength 254 nm, which show a high intense peak at 613 nm for Y2O3:Dy3+, Eu3+ (1:1...
January 16, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29340643/association-of-low-luminance-questionnaire-with-objective-functional-measures-in-early-and-intermediate-age-related-macular-degeneration
#3
Atalie C Thompson, Ulrich F O Luhmann, Sandra S Stinnett, Lejla Vajzovic, Anupama Horne, Cynthia A Toth, Scott W Cousins, Eleonora M Lad
Purpose: To determine whether Low Luminance Questionnaire (LLQ) scores are associated with objective measures of visual function in early and intermediate age-related macular degeneration (AMD). Methods: Cross-sectional study of subjects with early AMD Age-Related Eye Disease Study (AREDS) stage 2, N = 33), intermediate AMD (AREDS stage 3, N = 47), and age-matched healthy controls (N = 21). Subjects were interviewed with the LLQ. Psychophysical tests performed included best-corrected visual acuity (BCVA), mesopic microperimetry, dark adaptometry (DA), low luminance visual acuity (LLVA), and cone contrast test (CCT)...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29339327/the-chaperonin-cct-promotes-the-formation-of-fibrillar-aggregates-of-%C3%AE-tubulin
#4
Luis Pouchucq, Pablo Lobos-Ruiz, Gisela Araya, José María Valpuesta, Octavio Monasterio
The type II chaperonin CCT is involved in the prevention of the pathogenesis of numerous human misfolding disorders, as it sequesters misfolded proteins, blocks their aggregation and helps them to achieve their native state. In addition, it has been reported that CCT can prevent the toxicity of non-client amyloidogenic proteins by the induction of non-toxic aggregates, leading to new insight in chaperonin function as an aggregate remodeling factor. Here we add experimental evidence to this alternative mechanism by which CCT actively promotes the formation of conformationally different aggregates of γ-tubulin, a non-amyloidogenic CCT client protein, which are mediated by specific CCT-γ-tubulin interactions...
January 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29334923/relationship-between-corneal-biomechanical-properties-and-structural-biomarkers-in-patients-with-normal-tension-glaucoma-a-retrospective-study
#5
Keunheung Park, Jonghoon Shin, Jiwoong Lee
BACKGROUND: We evaluated the relationships between corneal biomechanical properties and structural parameters in patients with newly diagnosed, untreated normal-tension glaucoma (NTG). METHODS: All subjects were evaluated using an Ocular Response Analyzer (ORA) measuring corneal hysteresis (CH) and the corneal resistance factor (CRF). Central corneal thickness (CCT), Goldmann applanation tonometric (GAT) data, axial length, and the spherical equivalent (SE), were also measured...
January 15, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29332120/severe-loss-of-tritan-color-discrimination-in-rpe65-associated-leber-congenital-amaurosis
#6
Neruban Kumaran, Caterina Ripamonti, Angelos Kalitzeos, Gary S Rubin, James W B Bainbridge, Michel Michaelides
Purpose: RPE65-associated Leber congenital amaurosis (RPE65-LCA) is a progressive severe retinal dystrophy with early profound dysfunction of rod photoreceptors followed by progressive cone photoreceptor degeneration. We aim to provide detailed information about how cone dysfunction affects color discrimination. Methods: Seven adults (aged 16-21) with RPE65-LCA underwent monocular color discrimination assessment using the Trivector and Ellipse versions of three computerized tests: Cambridge Colour Test (CCT), low vision version of the Cambridge Colour Test (lvvCCT), and the Universal Colour Discrimination Test (UCDT)...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29328064/south-african-eye-study-saes-ethnic-differences-in-central-corneal-thickness-and-intraocular-pressure
#7
S O Baboolal, D P Smit
PurposeGlaucoma is the leading cause of irreversible blindness worldwide. South Africa has a diverse population but there is a lack of published ethnic specific normative data. The purpose of the study is to determine the distribution of intraocular pressure (IOP) and central corneal thickness (CCT) values in a multi-ethnic South African population and to determine additional systemic and ocular factors that influence IOP and CCT.Patients and methodsThis cross-sectional study included a total of 402 participants with 706 eyes aged 18-94 years...
January 12, 2018: Eye
https://www.readbyqxmd.com/read/29324896/correlation-of-the-anterior-ocular-segment-biometry-with-hba1c-level-in-type-2-diabetes-mellitus-patients
#8
Abd-Rashid Suraida, Mohtar Ibrahim, Embong Zunaina
OBJECTIVES: To compare the anterior ocular segment biometry among Type 2 diabetes mellitus (DM) with no diabetic retinopathy (DR) and non-proliferative diabetic retinopathy (NPDR), and to evaluate the correlation of anterior ocular segment biometry with HbA1c level. METHODS: A cross-sectional study was conducted in Hospital Universiti Sains Malaysia, Kelantan from November 2013 till May 2016 among Type 2 DM patients (DM with no DR and DM with NPDR). The patients were evaluated for anterior ocular segment biometry [central corneal thickness (CCT), anterior chamber width (ACW), angle opening distance (AOD) and anterior chamber angle (ACA)] by using Anterior Segment Optical Coherence Tomography (AS-OCT)...
2018: PloS One
https://www.readbyqxmd.com/read/29324716/the-effects-of-a-macromolecular-charring-agent-with-gas-phase-and-condense-phase-synergistic-flame-retardant-capability-on-the-properties-of-pp-ifr-composites
#9
Hongda Chen, Jihui Wang, Aiqing Ni, Anxin Ding, Xia Han, Ziheng Sun
In order to improve the efficiency of intumescent flame retardants (IFRs), a novel macromolecular charring agent named poly(ethanediamine-1,3,5-triazine-p-4-amino-2,2,6,6-tetramethylpiperidine) (PETAT) with gas phase and condense phase synergistic flame-retardant capability was synthesized and subsequently dispersed into polypropylene (PP) in combination with ammonium polyphosphate (APP) via a melt blending method. The chemical structure of PETAT was investigated by Fourier transform infrared spectroscopy (FTIR), and ¹H nuclear magnetic resonance (NMR) spectroscopy...
January 11, 2018: Materials
https://www.readbyqxmd.com/read/29320469/evaluation-of-the-simultaneous-production-of-xylitol-and-ethanol-from-sisal-fiber
#10
Franklin Damião Xavier, Gustavo Santos Bezerra, Sharline Florentino Melo Santos, Líbia Sousa Conrado Oliveira, Flávio Luiz Honorato Silva, Aleir Joice Oliveira Silva, Marta Maria Conceição
Recent years have seen an increase in the use of lignocellulosic materials in the development of bioproducts. Because sisal fiber is a low cost raw material and is readily available, this work aimed to evaluate its hemicellulose fraction for the simultaneous production of xylitol and ethanol. The sisal fiber presented a higher hemicellulose content than other frequently-employed biomasses, such as sugarcane bagasse. A pretreatment with dilute acid and low temperatures was conducted in order to obtain the hemicellulose fraction...
January 10, 2018: Biomolecules
https://www.readbyqxmd.com/read/29319223/zmcol3-a-cct-gene-represses-flowering-in-maize-by-interfering-circadian-clock-and-activating-expression-of-zmcct
#11
Minliang Jin, Xiangguo Liu, Wei Jia, Haijun Liu, Wenqiang Li, Yong Peng, Yanfang Du, Yuebin Wang, Yuejia Yin, Xuehai Zhang, Qing Liu, Min Deng, Nan Li, Xiyan Cui, Dongyun Hao, Jianbing Yan
Flowering time is a trait vital to the adaptation of flowering plants to different environments. Here, we report that CCT domain genes play an important role in flowering in maize (Zea mays L.). Among the 53 CCT family genes we identified in maize, 28 were located in flowering time quantitative trait locus regions and 15 were significantly associated with flowering time based on candidate-gene association mapping analysis. Furthermore, a CCT gene named ZmCOL3 was shown to be a repressor of flowering. Overexpressing ZmCOL3 delayed flowering time by approximately 4 days, in either long-day or short-day conditions...
January 10, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29305345/corneal-endothelial-alterations-in-alcohol-dependence-syndrome
#12
Alok Sati, Parthasarathi Moulick, Sandeep Shankar, Kaushik Chatterjee, Arun Kumar Dwivedi, Jayesh Vazirani
BACKGROUND/AIMS: To evaluate the corneal endothelial changes in patients with alcohol dependence syndrome (ADS). METHODS: A total of 322 corneas of 322 subjects were studied, and two groups were formed. The first, the ADS group, included 161 corneas of 161 patients and the second, the age-matched control group, was composed of 161 corneas of 161 healthy subjects. Both the groups were examined by specular microscope and the endothelial parameters were compared. The endothelial parameters were also compared before and after the abstinence of alcohol in the former group...
January 5, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29302786/intraoperative-changes-in-corneal-structure-during-excimer-laser-phototherapeutic-keratectomy-ptk-assessed-by-intraoperative-optical-coherence-tomography
#13
Sebastian Siebelmann, Jens Horstmann, Paula Scholz, Björn Bachmann, Mario Matthaei, Manuel Hermann, Claus Cursiefen
PURPOSE: Excimer laser phototherapeutic keratectomy (PTK) is a safe treatment for superficial corneal opacities, e.g., in corneal dystrophies or degenerations. Nevertheless, no standardized treatment protocols are available and intraoperative monitoring was not possible, so far. Here we evaluate the potential benefits of the intraoperative assessment by microscope-integrated intraoperative optical coherence tomography (MI-OCT) of corneal optical properties during PTK. METHODS: Retrospective study of eight patients (one male, seven females; age range, 43-80 years, mean = 66...
January 4, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29301514/goldmann-and-error-correcting-tonometry-prisms-compared-to-intracameral-pressure
#14
Sean McCafferty, Jason Levine, Jim Schwiegerling, Eniko T Enikov
BACKGROUND: Compare Goldmann applanation tonometer (GAT) prism and correcting applanation tonometry surface (CATS) prism to intracameral intraocular pressure (IOP), in vivo and in vitro. METHODS: Pressure transducer intracameral IOP was measured on fifty-eight (58) eyes undergoing cataract surgery and the IOP was modulated manometrically to 10, 20, and 40 mmHg. Simultaneously, IOP was measured using a Perkins tonometer with a standard GAT prism and a CATS prism at each of the intracameral pressures...
January 4, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29300995/evaluation-of-the-saline-infusion-test-and-the-captopril-challenge-test-in-chinese-patients-with-primary-aldosteronism
#15
Xiao Meng, Yanyan Li, Xiaohao Wang, Jianwei Li, Yuping Liu, Yerong Yu
Context: The aim of this study was to determine whether the diagnosis cutoff values associated with the saline infusion test (SIT) and captopril challenge test (CCT) in The Endocrine Society guidelines are applicable to Chinese subjects. Objective and Design: We performed a head-to-head comparison of the SIT and CCT among Chinese subjects with primary aldosteronism (PA) and essential hypertension (EH). Participants and Setting: 164 hypertensive patients were enrolled...
December 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29299146/targeting-chaperonin-containing-tcp1-cct-as-a-molecular-therapeutic-for-small-cell-lung-cancer
#16
Ana C Carr, Amr S Khaled, Rania Bassiouni, Orielyz Flores, Daniel Nierenberg, Hammad Bhatti, Priya Vishnubhotla, J Perez Manuel, Santimukul Santra, Annette R Khaled
Identifying new druggable targets is desired to meet the needs for effective cancer treatments. To this end, we previously reported the efficacy of a therapeutic peptide called CT20p that displays selective cytotoxicity through inhibition of a multi-subunit, protein-folding complex called Chaperonin-Containing TCP-1 (CCT). To investigate the role of CCT in cancer progression, we examined protein levels of CCT subunits in liver, prostate, and lung cancer using human tissue microarrays. We found that these cancers expressed higher levels of CCT2 as compared to normal tissues...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288835/evaluation-of-anterior-segment-parameters-in-patients-with-turner-syndrome-using-scheimpflug-imaging
#17
Merve Inanc, Kemal Tekin, Erdal Kurnaz, Mehmet Citirik, Gülsah Altas, Zehra Aycan
PURPOSE: To compare the anterior segment parameters in patients with Turner syndrome (TS) as measured by the Pentacam HR-Scheimpflug imaging system with those of healthy control subjects. METHODS: This cross-sectional prospective study included 35 patients with TS and 30 age-matched controls. Corneal topographic analysis was performed using the Pentacam HR-Scheimpflug imaging system (Oculus, Wetzlar, Germany). The power of the corneal astigmatism, mean keratometry (Km) values for the both front and back surfaces of the cornea, maximum keratometry (Kmax), central corneal thickness (CCT), corneal volume (CoV), white-to-white diameter (WTW), chamber volume (CaV), angle and anterior chamber depth (ACD) values were recorded...
December 27, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29284444/comparison-of-efficacy-between-coaxial-microincision-and-standard-incision-phacoemulsification-in-patients-with-age-related-cataracts-a-meta-analysis
#18
Lijun Wang, Xiao Xiao, Lin Zhao, Yi Zhang, Jianming Wang, Aiyi Zhou, Jianchao Wang, Qian Wu
BACKGROUND: Incision size plays a critical role in the efficacy of cataract surgery, but the available evidence on ideal incision size is inconsistent. In this study, we conducted a meta-analysis to evaluate the efficacy of coaxial microincisional phacoemulsification surgery (MICS) compared with that of standard-incision phacoemulsification surgery (SICS) in patients with age-related cataracts. METHODS: The Cochrane Library (Wiley Online Library), PubMed, Medline, National Knowledge Infrastructure (CNKI), and VIP databases were searched to identify reports of clinical randomized controlled trials (RCTs) comparing MICS to SICS for the treatment of age-related cataracts...
December 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29283924/comparison-of-changes-in-central-corneal-thickness-during-corneal-collagen-cross-linking-using-isotonic-riboflavin-solutions-with-and-without-dextran-in-the-treatment-of-progressive-keratoconus
#19
Naima Zaheer, Wajid Ali Khan, Shama Khan, M Abdul Moqeet Khan
PURPOSE: To compare intraoperative changes in central corneal thickness (CCT) during corneal cross-linking, using 2 different isotonic riboflavin solutions either with dextran or with hydroxy propyl methylcellulose, in the treatment of progressive keratoconus. METHODS: In this retrospective study, we analyzed records of corneal thickness measurements, taken during various steps of cross-linking. Cross-linking was performed using either isotonic riboflavin with dextran (group A) or isotonic riboflavin with hydroxy propyl methylcellulose (without dextran) (group B)...
December 27, 2017: Cornea
https://www.readbyqxmd.com/read/29283900/corneal-biomechanical-properties-and-central-corneal-thickness-in-pediatric-noninfectious-uveitis-a-controlled-study
#20
Emine Sen, Melike Balikoglu-Yilmaz, Pinar Ozdal
OBJECTIVE: To compare the corneal biomechanics, intraocular pressure (IOP), and central corneal thickness (CCT) of 37 patients with pediatric noninfectious uveitis with 36 healthy children. METHODS: Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated and corneal-compensated IOP (IOPg and IOPcc, respectively), and CCT were measured. RESULTS: The mean CRF was significantly lower in the pediatric uveitic eyes than controls (9...
December 27, 2017: Eye & Contact Lens
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