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3D Bioprinting

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https://www.readbyqxmd.com/read/29215164/magnetically-guided-self-assembly-and-coding-of-3d-living-architectures
#1
Alessandro Tocchio, Naside Gozde Durmus, Kaushik Sridhar, Vigneshwaran Mani, Bukre Coskun, Rami El Assal, Utkan Demirci
In nature, cells self-assemble at the microscale into complex functional configurations. This mechanism is increasingly exploited to assemble biofidelic biological systems in vitro. However, precise coding of 3D multicellular living materials is challenging due to their architectural complexity and spatiotemporal heterogeneity. Therefore, there is an unmet need for an effective assembly method with deterministic control on the biomanufacturing of functional living systems, which can be used to model physiological and pathological behavior...
December 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29214803/shear-thinning-and-thermo-reversible-nanoengineered-inks-for-3d-bioprinting
#2
Scott A Wilson, Lauren M Cross, Charles W Peak, Akhilesh K Gaharwar
Three-dimensional (3D) printing is an emerging approach for rapid fabrication of complex tissue structures using cell-loaded bioinks. However, 3D bioprinting has hit a bottleneck in progress because of the lack of suitable bioinks that are printable, have high shape fidelity, and are mechanically resilient. In this study, we introduce a new family of nanoengineered bioinks consisting of kappa-carrageenan (κCA) and two-dimensional (2D) nanosilicates (nSi). κCA is a biocompatible, linear, sulfated polysaccharide derived from red algae and can undergo thermo-reversible and ionic gelation...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29213126/tuning-alginate-bioink-stiffness-and-composition-for-controlled-growth-factor-delivery-and-to-spatially-direct-msc-fate-within-bioprinted-tissues
#3
Fiona E Freeman, Daniel J Kelly
Alginate is a commonly used bioink in 3D bioprinting. Matrix stiffness is a key determinant of mesenchymal stem cell (MSC) differentiation, suggesting that modulation of alginate bioink mechanical properties represents a promising strategy to spatially regulate MSC fate within bioprinted tissues. In this study, we define a printability window for alginate of differing molecular weight (MW) by systematically varying the ratio of alginate to ionic crosslinker within the bioink. We demonstrate that the MW of such alginate bioinks, as well as the choice of ionic crosslinker, can be tuned to control the mechanical properties (Young's Modulus, Degradation Rate) of 3D printed constructs...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208279/collagen-alginate-as-bioink-for-three-dimensional-3d-cell-printing-based-cartilage-tissue-engineering
#4
Xingchen Yang, Zhenhui Lu, Huayu Wu, Wei Li, Li Zheng, Jinmin Zhao
Articular cartilage repair is still a huge challenge for researchers and clinicians. 3D bioprinting could be an innovative technology for cartilage tissue engineering. In this study, we used collagen type I (COL) or agarose (AG) mixed with sodium alginate (SA) to serve as 3D bioprinting bioinks and incorporated chondrocytes to construct in vitro 3D printed cartilage tissue. Swelling ratio, mechanical properties, scanning electron microscopy (SEM), cell viability and cytoskeleton, biochemistry analysis and quantitative real-time polymerase chain reaction (qRT-PCR) were performed to investigate the function of different bioinks in 3D printing cartilage tissue engineering applications...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29203812/a-highly-printable-and-biocompatible-hydrogel-composite-for-direct-printing-of-soft-and-perfusable-vasculature-like-structures
#5
Ratima Suntornnond, Edgar Yong Sheng Tan, Jia An, Chee Kai Chua
Vascularization is one major obstacle in bioprinting and tissue engineering. In order to create thick tissues or organs that can function like original body parts, the presence of a perfusable vascular system is essential. However, it is challenging to bioprint a hydrogel-based three-dimensional vasculature-like structure in a single step. In this paper, we report a new hydrogel-based composite that offers impressive printability, shape integrity, and biocompatibility for 3D bioprinting of a perfusable complex vasculature-like structure...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29200661/spatially-and-temporally-controlled-hydrogels-for-tissue-engineering
#6
Jeroen Leijten, Jungmok Seo, Kan Yue, Grissel Trujillo-de Santiago, Ali Tamayol, Guillermo U Ruiz-Esparza, Su Ryon Shin, Roholah Sharifi, Iman Noshadi, Mario Moisés Álvarez, Yu Shrike Zhang, Ali Khademhosseini
Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels' properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and three-dimensional (3D) bioprinting, as well as advances in the temporal control of biomaterials, such as controlled release of molecules, photocleaving of proteins, and controlled hydrogel degradation...
September 2017: Materials Science & Engineering. R, Reports: a Review Journal
https://www.readbyqxmd.com/read/29199637/automated-3d-bioassembly-of-micro-tissues-for-biofabrication-of-hybrid-tissue-engineered-constructs
#7
Naveen Vijayan Mekhileri, Khoon Lim, Gabriella C J Brown, Isha Mutreja, Ben S Schon, Gary J Hooper, Tim B F Woodfield
Bottom-up biofabrication approaches combining micro-tissue fabrication techniques with extrusion-based 3D printing of thermoplastic polymer scaffolds are emerging strategies in tissue engineering. These biofabrication strategies support native self-assembly mechanisms observed in developmental stages of tissue or organoid growth as well as promoting cell-cell interactions and cell differentiation capacity. Few technologies have been developed to automate the precise assembly of micro-tissues or tissue modules into structural scaffolds...
December 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/29197301/dispensing-based-bioprinting-of-mechanically-functional-hybrid-scaffolds-with-vessel-like-channels-for-tissue-engineering-applications-a-brief-review
#8
REVIEW
Saman Naghieh, Md Sarker, Mohammad Izadifar, Xiongbiao Chen
Over the past decades, significant progress has been achieved in the field of tissue engineering (TE) to restore/repair damaged tissues or organs and, in this regard, scaffolds made from biomaterials have played a critical role. Notably, recent advances in biomaterials and three-dimensional (3D) printing have enabled the manipulation of two or more biomaterials of distinct, yet complementary, mechanical and/or biological properties to form so-called hybrid scaffolds mimicking native tissues. Among various biomaterials, hydrogels synthesized to incorporate living cells and/or biological molecules have dominated due to their hydrated tissue-like environment...
November 26, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29193879/organ-bioprinting-are-we-there-yet
#9
REVIEW
Guifang Gao, Ying Huang, Arndt F Schilling, Karen Hubbell, Xiaofeng Cui
About 15 years ago, bioprinting was coined as one of the ultimate solutions to engineer vascularized tissues, which was impossible to accomplish using the conventional tissue fabrication approaches. With the advances of 3D-printing technology during the past decades, one may expect 3D bioprinting being developed as much as 3D printing. Unfortunately, this is not the case. The printing principles of bioprinting are dramatically different from those applied in industrialized 3D printing, as they have to take the living components into account...
November 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29191399/from-axenic-to-mixed-cultures-technological-advances-accelerating-a-paradigm-shift-in-microbiology
#10
REVIEW
Corrado Nai, Vera Meyer
Since the onset of microbiology in the late 19th century, scientists have been growing microorganisms almost exclusively as pure cultures, resulting in a limited and biased view of the microbial world. Only a paradigm shift in cultivation techniques - from axenic to mixed cultures - can allow a full comprehension of the (chemical) communication of microorganisms, with profound consequences for natural product discovery, microbial ecology, symbiosis, and pathogenesis, to name a few areas. Three main technical advances during the last decade are fueling the realization of this revolution in microbiology: microfluidics, next-generation 3D-bioprinting, and single-cell metabolomics...
November 27, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/29176756/cryogenic-3d-printing-of-super-soft-hydrogels
#11
Zhengchu Tan, Cristian Parisi, Lucy Di Silvio, Daniele Dini, Antonio Elia Forte
Conventional 3D bioprinting allows fabrication of 3D scaffolds for biomedical applications. In this contribution we present a cryogenic 3D printing method able to produce stable 3D structures by utilising the liquid to solid phase change of a composite hydrogel (CH) ink. This is achieved by rapidly cooling the ink solution below its freezing point using solid carbon dioxide (CO2) in an isopropanol bath. The setup was able to successfully create 3D complex geometrical structures, with an average compressive stiffness of O(1) kPa (0...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29176035/coaxial-extrusion-bioprinting-of-3d-microfibrous-constructs-with-cell-favorable-gelatin-methacryloyl-microenvironments
#12
Wanjun Liu, Zhe Zhong, Ning Hu, Yixiao Zhou, Lucia Maggio, Amir Miri, Alessio Fragasso, Xiangyu Jin, Ali Khademhosseini, Yu Shrike Zhang
Bioinks with shear-thinning/rapid solidification properties and strong mechanics are usually needed for the bioprinting of three-dimensional (3D) cell-laden constructs. As such, it remains challenging to generate soft constructs from bioinks at low concentrations that are favorable for cellular activities. Herein, we report a strategy to fabricate cell-laden constructs with tunable 3D microenvironments achieved by bioprinting of gelatin methacryloyl (GelMA)/alginate core/sheath microfibers, where the alginate sheath serves as a template to support and confine the GelMA pre-hydrogel in the core during the extrusion process, allowing for subsequent UV crosslinking...
November 27, 2017: Biofabrication
https://www.readbyqxmd.com/read/29172145/a-novel-3d-bioprinted-flexible-and-biocompatible-hydrogel-bioelectronic-platform
#13
Shweta Agarwala, Jia Min Lee, Wei Long Ng, Michael Layani, Wai Yee Yeong, Shlomo Magdassi
Bioelectronics platforms are gaining widespread attention as they provide a template to study the interactions between biological species and electronics. Decoding the effect of the electrical signals on the cells and tissues holds the promise for treating the malignant tissue growth, regenerating organs and engineering new-age medical devices. This work is a step forward in this direction, where bio- and electronic materials co-exist on one platform without any need for post processing. We fabricate a freestanding and flexible hydrogel based platform using 3D bioprinting...
November 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29171867/enthusiastic-portrayal-of-3d-bioprinting-in-the-media-ethical-side-effects
#14
Frederic Gilbert, John Noel M Viaña, Cathal D O'Connell, Susan Dodds
There has been a surge in mass media reports extolling the potential for using three-dimensional printing of biomaterials (3D bioprinting) to treat a wide range of clinical conditions. Given that mass media is recognized as one of the most important sources of health and medical information for the general public, especially prospective patients, we report and discuss the ethical consequences of coverage of 3D bioprinting in the media. First, we illustrate how positive mass media narratives of a similar biofabricated technology, namely the Macchiarini scaffold tracheas, which was involved in lethal experimental human trials, influenced potential patient perceptions...
November 24, 2017: Bioethics
https://www.readbyqxmd.com/read/29171415/using-3d-bioprinting-to-produce-mini-brain
#15
Hao-Wei Han, Shan-Hui Hsu
No abstract text is available yet for this article.
October 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29164196/supramolecular-polymeric-biomaterials
#16
REVIEW
Joseph L Mann, Anthony C Yu, Gillie Agmon, Eric A Appel
Polymeric chains crosslinked through supramolecular interactions-directional and reversible non-covalent interactions-compose an emerging class of modular and tunable biomaterials. The choice of chemical moiety utilized in the crosslink affords different thermodynamic and kinetic parameters of association, which in turn illustrate the connectivity and dynamics of the system. These parameters, coupled with the choice of polymeric architecture, can then be engineered to control environmental responsiveness, viscoelasticity, and cargo diffusion profiles, yielding advanced biomaterials which demonstrate rapid shear-thinning, self-healing, and extended release...
November 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29148982/a-dentin-derived-hydrogel-bioink-for-3d-printing-of-cell-laden-scaffolds-for-regenerative-dentistry
#17
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane Miranda Franca, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
November 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/29147690/physiological-ph-dependent-gelation-for-3d-printing-based-on-the-phase-separation-of-gelatin-and-oxidized-dextran
#18
Zengmin Du, Ningfeng Li, Yujie Hua, Yong Shi, Chunyan Bao, Hongbo Zhang, Yi Yang, Qiuning Lin, Linyong Zhu
An extrudable hydrogel with a tunable gelation time under physiological pH ranges based on the phase separation of gelatin and oxidized dextran was demonstrated. We envision that the easy handing properties of this hydrogel combined with thermosensitive physical gelation and postponed chemical reinforcing will provide a platform for 3D bioprinting applications.
November 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29139103/differentiation-potential-of-human-adipose-stem-cells-bioprinted-with-hyaluronic-acid-gelatin-based-bioink-through-microextrusion-and-visible-light-initiated-crosslinking
#19
Shinji Sakai, Hiromi Ohi, Tomoki Hotta, Hidenori Kamei, Masahito Taya
Bioprinting has a great potential to fabricate three-dimensional (3D) functional tissues and organs. In particular, the technique enables fabrication of 3D constructs containing stem cells while maintaining cell proliferation and differentiation abilities, which is believed to be promising in the fields of tissue engineering and regenerative medicine. We aimed to demonstrate the utility of the bioprinting technique to create hydrogel constructs consisting of hyaluronic acid (HA) and gelatin derivatives through irradiation by visible light to fabricate 3D constructs containing human adipose stem cells (hADSCs)...
November 15, 2017: Biopolymers
https://www.readbyqxmd.com/read/29134949/pla-short-sub-micron-fiber-reinforcement-of-3d-bioprinted-alginate-constructs-for-cartilage-regeneration
#20
Alicja Kosik-Kozioł, Marco Costantini, Tomasz Bolek, Krisztina Szöke, Andrea Barbetta, Jan Brinchmann, Wojciech Święszkowski
In this study, we present an innovative strategy to reinforce 3D-printed hydrogel constructs for cartilage tissue engineering by formulating composite bioinks containing alginate and short sub-micron polylactide (PLA) fibers. We demonstrate that Young's modulus obtained for pristine alginate constructs (6.9 ± 1.7 kPa) can be increased threefold (up to 25.1 ± 3.8 kPa) with the addition of PLA short fibers. Furthermore, to assess the performance of such materials in cartilage tissue engineering, we loaded the bioinks with human chondrocytes and cultured in vitro the bioprinted constructs for up to 14 days...
November 14, 2017: Biofabrication
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