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3D Bioprinting

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https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#1
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29446757/3d-bioprinting-mesenchymal-stem-cell-laden-construct-with-core-shell-nanospheres-for-cartilage-tissue-engineering
#2
Wei Zhu, Haitao Cui, Benchaa Boualam, Fahed Masood, Erin Flynn, Raj Rao, Zhiyong Zhang, Lijie Grace Zhang
Cartilage tissue is prone to degradation and has little capacity for self-healing due to its avascularity. Tissue engineering, which provides artificial scaffolds to repair injured tissues, is a novel and promising strategy for cartilage repair. 3D bioprinting offers even greater potential for repairing degenerative tissue by simultaneously integrating living cells, biomaterials, and biological cues to provide a customized scaffold. With regard to cell selection, mesenchymal stem cells (MSCs) hold great capacity for differentiating into a variety of cell types, including chondrocytes, and could therefore be utilized as a cartilage cell source in 3D bioprinting...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29445812/3d-cellular-structures-and-co-cultures-formed-through-the-contactless-magnetic-manipulation-of-cells-on-adherent-surfaces
#3
Abdel Rahman Abdel Fattah, Sarah Mishriki, Tobias Kammann, Rakesh P Sahu, Fei Geng, Ishwar K Puri
A magnet array is employed to manipulate diamagnetic cells that are contained in paramagnetic medium to demonstrate for the first time the contactless bioprinting of three-dimensional (3D) cellular structures and co-cultures of breast cancer MCF-7 and endothelial HUVEC at prescribed locations on tissue culture treated well plates. Sequential seeding of different cell lines and the spatial displacement of the magnet array creates co-cultured cellular structures within a well without using physically intrusive well inserts...
February 15, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29438729/hyaluronan-chemistries-for-three-dimensional-matrix-applications
#4
REVIEW
Monica A Serban, Aleksander Skardal
Hyaluronan is a ubiquitous constituent of mammalian extracellular matrices and, because of its excellent intrinsic biocompatibility and chemical modification versatility, has been widely employed in a multitude of biomedical applications. In this article, we will survey the approaches used to tailor hyaluronan to specific needs of tissue engineering, regenerative and reconstructive medicine and overall biomedical research. We will also describe recent examples of applications in these broader areas, such as 3D cell culture, bioprinting, organoid biofabrication, and precision medicine that are facilitated by the use of hyaluronan as a biomaterial...
February 10, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29428560/enabling-personalized-implant-and-controllable-biosystem-development-through-3d-printing
#5
REVIEW
Neerajha Nagarajan, Agnes Dupret-Bories, Erdem Karabulut, Pinar Zorlutuna, Nihal Engin Vrana
The impact of additive manufacturing in our lives has been increasing constantly. One of the frontiers in this change is the medical devices. 3D printing technologies not only enable the personalization of implantable devices with respect to patient-specific anatomy, pathology and biomechanical properties but they also provide new opportunities in related areas such as surgical education, minimally invasive diagnosis, medical research and disease models. In this review, we cover the recent clinical applications of 3D printing with a particular focus on implantable devices...
February 8, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29425719/cell-reprogramming-by-3d-bioprinting-of-human-fibroblasts-in-polyurethane-hydrogel-for-fabrication-of-neural-like-constructs
#6
Lin Ho, Shan-Hui Hsu
3D bioprinting is a technique which enables the direct printing of biodegradable materials with cells into 3D tissue. So far there is no cell reprogramming in situ performed with the 3D bioprinting process. Forkhead box D3 (FoxD3) is a transcription factor and neural crest marker, which was reported to reprogram human fibroblasts into neural crest stem-like cells. In this study, we synthesized a new biodegradable thermo-responsive waterborne polyurethane (PU) gel as a bioink. FoxD3 plasmids and human fibroblasts were co-extruded with the PU hydrogel through the syringe needle tip for cell reprogramming...
February 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29422410/tissue-engineering-3d-neurovascular-units-a-biomaterials-and-bioprinting-perspective
#7
REVIEW
Geoffrey Potjewyd, Samuel Moxon, Tao Wang, Marco Domingos, Nigel M Hooper
Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) components in an important interface whose correct functioning is critical to maintain brain health. Tissue engineering is now offering new tools and insights to advance our understanding of NVU function. Here, we review how the use of novel biomaterials to mimic the mechanical and functional cues of the ECM, coupled with precisely layered deposition of the different cells of the NVU through 3D bioprinting, is revolutionising the study of neurovascular function and dysfunction...
February 5, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29414913/novel-biomaterials-used-in-medical-3d-printing-techniques
#8
REVIEW
Karthik Tappa, Udayabhanu Jammalamadaka
The success of an implant depends on the type of biomaterial used for its fabrication. An ideal implant material should be biocompatible, inert, mechanically durable, and easily moldable. The ability to build patient specific implants incorporated with bioactive drugs, cells, and proteins has made 3D printing technology revolutionary in medical and pharmaceutical fields. A vast variety of biomaterials are currently being used in medical 3D printing, including metals, ceramics, polymers, and composites. With continuous research and progress in biomaterials used in 3D printing, there has been a rapid growth in applications of 3D printing in manufacturing customized implants, prostheses, drug delivery devices, and 3D scaffolds for tissue engineering and regenerative medicine...
February 7, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29414466/influence-of-crosslinking-on-the-mechanical-behavior-of-3d-printed-alginate-scaffolds-experimental-and-numerical-approaches
#9
Saman Naghieh, Mohammad Reza Karamooz-Ravari, M D Sarker, Eva Karki, Xiongbiao Chen
Tissue scaffolds fabricated by three-dimensional (3D) bioprinting are attracting considerable attention for tissue engineering applications. Because the mechanical properties of hydrogel scaffolds should match the damaged tissue, changing various parameters during 3D bioprinting has been studied to manipulate the mechanical behavior of the resulting scaffolds. Crosslinking scaffolds using a cation solution (such as CaCl2) is also important for regulating the mechanical properties, but has not been well documented in the literature...
January 31, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29413501/integration-of-3d-printing-and-additive-manufacturing-in-the-interventional-pulmonologist-s-toolbox
#10
Nicolas Guibert, Laurent Mhanna, Alain Didier, Benjamin Moreno, Pierre Leyx, Gavin Plat, Julien Mazieres, Christophe Hermant
New 3D technologies are rapidly entering into the surgical landscape, including in interventional pulmonology. The transition of 2D restricted data into a physical model of pathological airways by three-dimensional printing (3DP) allows rapid prototyping and fabrication of complex and patient-specific shapes and can thus help the physician to plan and guide complex procedures. Furthermore, computer-assisted designed (CAD) patient-specific devices have already helped surgeons overcome several therapeutic impasses and are likely to rapidly cover a wider range of situations...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29405059/3d-bioprinting-of-low-concentration-cell-laden-gelatin-methacrylate-gelma-bioinks-with-two-step-crosslinking-strategy
#11
Jun Yin, Mengling Yan, Yancheng Wang, Jianzhong Fu, Hairui Suo
Methacrylated gelatin (GelMA) has been widely used as the tissue engineered scaffold material, but only low concentration GelMA hydrogels were found to be promising cell-laden bioinks with excellent cell viability. In this work, we reported a strategy for precisely deposition of 5% (w/v) cell-laden GelMA bioinks into controlled micro-architectures with high cell viability using extrusion-based three-dimensional (3D) bioprinting. By adding gelatin into GelMA bioinks, a two-step crosslinking combining the rapid and reversible thermo-crosslinking of gelatin with irreversible photo-crosslinking of GelMA was achieved...
February 6, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29404374/bioprinting-of-skin-constructs-for-wound-healing
#12
REVIEW
Peng He, Junning Zhao, Jiumeng Zhang, Bo Li, Zhiyuan Gou, Maling Gou, Xiaolu Li
Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the need for skin tissues suitable for transplantation, and can lead to the development of skin equivalents for wound healing therapy...
2018: Burns and trauma
https://www.readbyqxmd.com/read/29383354/applying-macromolecular-crowding-to-3d-bioprinting-fabrication-of-3d-hierarchical-porous-collagen-based-hydrogel-constructs
#13
Wei Long Ng, Min Hao Goh, Wai Yee Yeong, May Win Naing
Native tissues and/or organs possess complex hierarchical porous structures that confer highly-specific cellular functions. Despite advances in fabrication processes, it is still very challenging to emulate the hierarchical porous collagen architecture found in most native tissues. Hence, the ability to recreate such hierarchical porous structures would result in biomimetic tissue-engineered constructs. Here, a single-step drop-on-demand (DOD) bioprinting strategy is proposed to fabricate hierarchical porous collagen-based hydrogels...
January 31, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29378379/-biofabrication-new-approaches-for-tissue-regeneration
#14
Raymund E Horch, Annika Weigand, Harald Wajant, J├╝rgen Groll, Aldo R Boccaccini, Andreas Arkudas
BACKGROUND: The advent of Tissue Engineering (TE) in the early 1990ies was fostered by the increasing need for functional tissue and organ replacement. Classical TE was based on the combination of carrier matrices, cells and growth factors to reconstitute lost or damaged tissue and organs. Despite considerable results in vitro and in experimental settings the lack of early vascularization has hampered its translation into daily clinical practice so far. A new field of research, called "biofabrication" utilizing latest 3D printing technologies aims at hierarchically and spatially incorporating different cells, biomaterials and molecules into a matrix to alleviate a directed maturation of artificial tissue...
January 29, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29371132/integrated-approaches-to-spatiotemporally-directing-angiogenesis-in-host-and-engineered-tissues
#15
REVIEW
Rajeev J Kant, Kareen L K Coulombe
The field of tissue engineering has turned towards biomimicry to solve the problem of tissue oxygenation and nutrient/waste exchange through the development of vasculature. Induction of angiogenesis and subsequent development of a vascular bed in engineered tissues is actively being pursued through combinations of physical and chemical cues, notably through the presentation of topographical and growth factor cues. Presenting angiogenic signals in a spatiotemporal fashion is beginning to generate improved vascular networks, which will allow for the creation of large and dense engineered tissues...
January 22, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29369541/hierarchical-design-of-tissue-regenerative-constructs
#16
REVIEW
Jonas C Rose, Laura De Laporte
The worldwide shortage of organs fosters significant advancements in regenerative therapies. Tissue engineering and regeneration aim to supply or repair organs or tissues by combining material scaffolds, biochemical signals, and cells. The greatest challenge entails the creation of a suitable implantable or injectable 3D macroenvironment and microenvironment to allow for ex vivo or in vivo cell-induced tissue formation. This review gives an overview of the essential components of tissue regenerating scaffolds, ranging from the molecular to the macroscopic scale in a hierarchical manner...
January 25, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29368378/placental-basement-membrane-proteins-are-required-for-effective-cytotrophoblast-invasion-in-a-3d-bioprinted-placenta-model
#17
Che-Ying Kuo, Ting Guo, Juan Cabrera-Luque, Navein Arumugasaamy, Laura Bracaglia, Amy Garcia-Vivas, Marco Santoro, Hannah Baker, John Fisher, Peter Kim
Fetal cytotrophoblast invasion of maternal decidual vasculature is necessary to normal pregnancy. In preeclampsia, there is shallow invasion and abnormal remodeling of the uterine vasculature that lead to significant maternal and perinatal morbidity and mortality. The placental basement membrane (BM) proteins (e.g. laminin, collagen) has been implicated in the development of placenta while the level of laminin is significantly lower in preeclampsia. However, there are very limited studies, if any, on the effect of extracellular matrix (ECM) microenvironment on the invasion of cytotrophoblast...
January 25, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29361754/advanced-material-strategies-for-next-generation-additive-manufacturing
#18
REVIEW
Jinke Chang, Jiankang He, Mao Mao, Wenxing Zhou, Qi Lei, Xiao Li, Dichen Li, Chee-Kai Chua, Xin Zhao
Additive manufacturing (AM) has drawn tremendous attention in various fields. In recent years, great efforts have been made to develop novel additive manufacturing processes such as micro-/nano-scale 3D printing, bioprinting, and 4D printing for the fabrication of complex 3D structures with high resolution, living components, and multimaterials. The development of advanced functional materials is important for the implementation of these novel additive manufacturing processes. Here, a state-of-the-art review on advanced material strategies for novel additive manufacturing processes is provided, mainly including conductive materials, biomaterials, and smart materials...
January 22, 2018: Materials
https://www.readbyqxmd.com/read/29360631/proof-of-concept-3d-bioprinting-of-pigmented-human-skin-constructs
#19
Wei Long Ng, Jovina Tan Zhi Qi, Wai Yee Yeong, May Win Naing
Three-dimensional (3D) pigmented human skin constructs have been fabricated using a 3D bioprinting approach. The 3D pigmented human skin constructs are obtained from using three different types of skin cells (keratinocytes, melanocytes and fibroblasts from three different skin donors) and they exhibit similar constitutive pigmentation (pale pigmentation) as the skin donors. A two-step drop-on-demand bioprinting strategy facilitates the deposition of cell droplets to emulate the epidermal melanin units (pre-defined patterning of keratinocytes and melanocytes at the desired positions) and manipulation of the microenvironment to fabricate 3D biomimetic hierarchical porous structures found in native skin tissue...
January 23, 2018: Biofabrication
https://www.readbyqxmd.com/read/29359861/silk-based-bioinks-for-3d-bioprinting
#20
REVIEW
Shikha Chawla, Swati Midha, Aarushi Sharma, Sourabh Ghosh
3D bioprinting field is making remarkable progress; however, the development of critical sized engineered tissue construct is still a farfetched goal. Silk fibroin offers a promising choice for bioink material. Nature has imparted several unique structural features in silk protein to ensure spinnability by silkworms or spider. Researchers have modified the structure-property relationship by reverse engineering to further improve shear thinning behavior, high printability, cytocompatible gelation, and high structural fidelity...
January 23, 2018: Advanced Healthcare Materials
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