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https://www.readbyqxmd.com/read/29446222/engineering-controls-in-veterinary-oncology-a-survey-of-148-acvim-board-certified-oncologists-and-environmental-surveillance-in-20-specialty-hospitals
#1
K Alexander, N Northrup, D Clarke, H Lindell, T Laver
Engineering controls (EC, facility and equipment barriers between hazards and people) are used to avoid exposure to chemotherapy drugs. In this study, American College of Veterinary Internal Medicine board-certified veterinary oncologists were surveyed about their use of containment primary EC (C-PEC) and supplemental EC (closed system transfer devices, CSTD). The survey was completed by 148 (38%) of practicing diplomates. All used EC. Both C-PEC and CSTD were used at 92% of hospitals; however, US Pharmacopoeial Convention Chapter <800> (USP <800>) standards were met at only 19% of hospitals and oncologists did not know the type of C-PEC at 18% of hospitals...
February 15, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29445835/application-and-evaluation-of-a-high-resolution-mass-spectrometry-screening-method-for-veterinary-drug-residues-in-incurred-fish-and-imported-aquaculture-samples
#2
Sherri B Turnipseed, Joseph M Storey, I-Lin Wu, Charles M Gieseker, Nicholas R Hasbrouck, Tina C Crosby, Wendy C Andersen, Shanae Lanier, Christine R Casey, Robert Burger, Mark R Madson
The ability to detect chemical contaminants, including veterinary drug residues in animal products such as fish, is an important example of food safety analysis. In this paper, a liquid chromatography high-resolution mass spectrometry (LC-HRMS) screening method using a quadrupole-Orbitrap instrument was applied to the analysis of veterinary drug residues in incurred tissues from aquacultured channel catfish, rainbow trout, and Atlantic salmon and imported aquacultured products including European eel, yellow croaker, and tilapia...
February 14, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29435436/osteosarcoma-accelerating-progress-makes-for-a-hopeful-future
#3
REVIEW
Amanda J Saraf, Joelle M Fenger, Ryan D Roberts
Patients who develop osteosarcoma in 2017 receive treatment that remains essentially unchanged since the 1970s. Outcomes likewise remain largely unimproved. Large, collaborative, multinational efforts to improve therapy have evaluated strategies leveraging both cytotoxic intensification and immunomodulatory agents. While these have confirmed our capacity to conduct such trials, results have proved largely disappointing. This has motivated efforts to focus on the basic biology of osteosarcoma, where understanding remains poor but has improved significantly...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29434539/sleep-and-sedative-states-induced-by-targeting-the-histamine-and-noradrenergic-systems
#4
REVIEW
Xiao Yu, Nicholas P Franks, William Wisden
Sedatives target just a handful of receptors and ion channels. But we have no satisfying explanation for how activating these receptors produces sedation. In particular, do sedatives act at restricted brain locations and circuitries or more widely? Two prominent sedative drugs in clinical use are zolpidem, a GABA A receptor positive allosteric modulator, and dexmedetomidine (DEX), a selective α2 adrenergic receptor agonist. By targeting hypothalamic neuromodulatory systems both drugs induce a sleep-like state, but in different ways: zolpidem primarily reduces the latency to NREM sleep, and is a controlled substance taken by many people to help them sleep; DEX produces prominent slow wave activity in the electroencephalogram (EEG) resembling stage 2 NREM sleep, but with complications of hypothermia and lowered blood pressure-it is used for long term sedation in hospital intensive care units-under DEX-induced sedation patients are arousable and responsive, and this drug reduces the risk of delirium...
2018: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29428778/base-catalyzed-hydrolysis-and-speciation-dependent-photolysis-of-two-cephalosporin-antibiotics-ceftiofur-and-cefapirin
#5
Alyson R Ribeiro, Holger V Lutze, Torsten C Schmidt
Lately, special attention has been given to veterinary cephalosporin antibiotics due to their broad activity spectrum and significant consumption. Indeed, the determination of hydrolytic and photolytic kinetics provides a better comprehension of the undesired persistence of cephalosporins in aqueous matrices. In this work, the two widely used veterinary antibiotics ceftiofur (CEF) and cefapirin (CEPA) showed high instability under alkaline conditions, degrading in few minutes at pH > 11. In buffered solutions at neutral pH and natural temperature (T = 22 ± 1 °C), both drugs presented moderate stability (t½ = 3 d, CEPA and 1...
December 22, 2017: Water Research
https://www.readbyqxmd.com/read/29426470/feline-leishmaniosis-is-the-cat-a-small-dog
#6
Maria Grazia Pennisi, Maria Flaminia Persichetti
Leishmania infantum is a vector-borne zoonotic disease transmitted by phlebotomine sand flies and dogs are considered the main reservoir of the parasite. Feline leishmaniosis (FeL) caused by L. infantum is an emergent feline disease more and more frequently reported in endemic areas. This review summarizes current knowledge focusing similarities and differences with canine leishmaniosis (CanL). Cats are infected by the same Leishmania species than dogs but prevalence of the infection is lower and cases of disease are less frequently reported...
February 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29426058/the-metabolism-of-flubendazole-in-human-liver-and-cancer-cell-lines
#7
Lucie Raisová Stuchlíková, Věra Králová, Kateřina Lněničková, Tomáš Zárybnický, Petra Matoušková, Veronika Hanušová, Martin Ambrož, Zdeněk Šubrt, Lenka Skálová
Flubendazole (FLU), a benzimidazole anthelmintic drug widely used in veterinary medicine, has been approved for the treatment of gut-residing nematodes in humans. In addition, FLU is now considered a promising anticancer agent. Despite this, information about biotransformation of this compound in human is lacking. Moreover, there is no information regarding whether cancer cells are able to metabolize FLU in order to deactivate it. For these reasons, the present study was designed to identify all metabolites of Phase I and Phase II of FLU in human liver and in various cancer cells using UHPLC/MS/MS analysis...
February 9, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29421996/role-of-abc-transporters-in-veterinary-medicine-pharmaco-toxicological-implications
#8
Guillermo Virkel, Mariana Ballent, Carlos Lanusse, Adrian Lifschitz
Unlike physicians, veterinary practitioners must deal with a number of animal species with crucial differences in anatomy, physiology and metabolism. Accordingly, the pharmacokinetic behaviour, the clinical efficacy and the adverse or toxic effects of drugs may differ across domestic animals. Moreover, the use of drugs in food-producing species may impose a risk for humans due to the generation of chemical residues in edible products, a major concern for public health and consumer's safety. As is clearly known in human beings, the ATP binding cassette (ABC) of transport proteins may influence the bioavailability and elimination of numerous drugs and other xenobiotics in domestic animals as well...
January 31, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29421751/veterinary-drug-17%C3%AE-trenbolone-promotes-the-proliferation-of-human-prostate-cancer-cell-line-through-the-akt-ar-signaling-pathway
#9
Hee-Seok Lee, Da-Woon Jung, Songyi Han, Hui-Seung Kang, Jin-Hyang Suh, Hyun-Suk Oh, Myung-Sil Hwang, Guiim Moon, Yooheon Park, Jin-Hwan Hong, Yong Eui Koo
Trenbolone acetate (TBA) is a synthetic anabolic steroidal growth factor that is used for rapid muscle development in cattle. The absorbed TBA is hydrolyzed to the active form, 17β-trenbolone (17 TB; 17β-hydroxy-estra-4,9,11-trien-3-one) in meat and milk products, which can cause adverse health effects in humans. Similar to 5α-dihydrotestosterone (DHT), 17 TB was reported to exhibit endocrine disrupting effects on animals and humans due to its androgenic effect via binding to the androgen receptor. The purpose of this study is to investigate the molecular mechanism of cell proliferation in prostate cancer (PCa) cells treated with 17 TB...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29416226/a-brief-review-on-the-mode-of-action-of-antinematodal-drugs
#10
Melanie Abongwa, Richard J Martin, Alan P Robertson
Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required...
June 2017: Acta Veterinaria
https://www.readbyqxmd.com/read/29414078/engineering-nanomaterials-based-biosensors-for-food-safety-detection
#11
REVIEW
Man Lv, Yang Liu, Jinhui Geng, Xiaohong Kou, Zhihong Xin, Dayong Yang
Food safety always remains a grand global challenge to human health, especially in developing countries. To solve food safety pertained problems, numerous strategies have been developed to detect biological and chemical contaminants in food. Among these approaches, nanomaterials-based biosensors provide opportunity to realize rapid, sensitive, efficient and portable detection, overcoming the restrictions and limitations of traditional methods such as complicated sample pretreatment, long detection time, and relying on expensive instruments and well-trained personnel...
February 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29413941/effect-of-diclofenac-on-the-production-of-volatile-fatty-acids-from-anaerobic-fermentation-of-waste-activated-sludge
#12
Jiawei Hu, Jianwei Zhao, Dongbo Wang, Xiaoming Li, Dan Zhang, Qiuxiang Xu, Lai Peng, Qi Yang, Guangming Zeng
In this study, the impact of diclofenac (DCF), an antiinflammatory drug being extensively used in human health care and veterinary treatment, on the production of volatile fatty acids (VFAs) from anaerobic fermentation of waste activated sludge (WAS) was investigated for the first time. Experimental results showed that when DCF concentration increased from 2.5 to 25 mg/kg total suspended solid (TSS), the maximum production of VFAs increased from 599 to 1113 mg COD/L, but further increase of DCF to 47...
January 13, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29408407/antimicrobial-susceptibility-survey-on-bacterial-agents-of-canine-and-feline-urinary-tract-infections-weight-of-the-empirical-treatment
#13
Elisa Rampacci, Marco Bottinelli, Valentina Stefanetti, Doreene R Hyatt, Elisa Sgariglia, Mauro Coletti, Fabrizio Passamonti
OBJECTIVES: This work characterizes the antimicrobial susceptibility of uropathogens isolated from empirically treated dogs and cats. Within-household transmission of uropathogens can involve humans and companion animals. Knowledge on the prevalence and susceptibility pattern of isolates from canine and feline urine samples and the impact of prior antimicrobial treatment is important to prevent the dissemination of antimicrobial resistance. METHODS: A retrospective study was conducted selecting antibiotically treated companion animals...
February 3, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29404665/target-screening-of-105-veterinary-drug-residues-in-milk-using-uhplc-esi-q-orbitrap-multiplexing-data-independent-acquisition
#14
Jian Wang, Daniel Leung, Willis Chow, James Chang, Jon W Wong
This paper presents a multi-class target screening method for the detection of 105 veterinary drug residues from 11 classes in milk using ultra-high performance liquid chromatography electrospray ionization quadrupole Orbitrap mass spectrometry (UHPLC/ESI Q-Orbitrap). The method is based on a non-target approach of full mass scan and multiplexing data-independent acquisition (Full MS/mDIA). The veterinary drugs include endectocides, fluoroquinolones, ionophores, macrolides, nitroimidazole, NSAIDs, β-lactams, penicillins, phenicols, sulfonamides, and tetracyclines...
February 5, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29402294/an-epidemiologic-study-of-antimicrobial-resistance-of-staphylococcus-species-isolated-from-equine-samples-submitted-to-a-diagnostic-laboratory
#15
Ronita Adams, Jackie Smith, Stephen Locke, Erica Phillips, Erdal Erol, Craig Carter, Agricola Odoi
BACKGROUND: Antimicrobial resistance limits traditional treatment options and increases costs. It is therefore important to estimate the magnitude of the problem so as to provide empirical data to guide control efforts. The aim of this study was to investigate the burden and patterns of antimicrobial resistance (AMR) among equine Staphylococcus samples submitted to the University of Kentucky Veterinary Diagnostic Laboratory (UKVDL) from 1993 to 2009. Retrospective data of 1711 equine Staphylococcus samples submitted to the UKVDL during the time period 1993 to 2009 were included in the study...
February 5, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29398528/completeness-of-handwritten-preanaesthetic-records-at-two-veterinary-referral-institutions
#16
Alastair Mair, Alessandra Mathis
OBJECTIVE: To retrospectively analyse handwritten preanaesthetic records for completeness at two veterinary referral institutions: a university veterinary teaching hospital and a private veterinary referral hospital. To evaluate if emergency records were less complete compared with non-emergency records. Animal or Animal Population Two hundred and fifty preanaesthetic records at each referral institution. MATERIALS AND METHODS: Handwritten preanaesthetic records were analysed for completeness...
September 18, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29389871/a-simple-surface-enhanced-raman-spectroscopic-method-for-on-site-screening-of-tetracycline-residue-in-whole-milk
#17
Sagar Dhakal, Kuanglin Chao, Qing Huang, Moon Kim, Walter Schmidt, Jianwei Qin, C Leigh Broadhurst
Therapeutic and subtherapeutic use of veterinary drugs has increased the risk of residue contamination in animal food products. Antibiotics such as tetracycline are used for mastitis treatment of lactating cows. Milk expressed from treated cows before the withdrawal period has elapsed may contain tetracycline residue. This study developed a simple surface-enhanced Raman spectroscopic (SERS) method for on-site screening of tetracycline residue in milk and water. Six batches of silver colloid nanoparticles were prepared for surface enhancement measurement...
February 1, 2018: Sensors
https://www.readbyqxmd.com/read/29381714/extended-spectrum-beta-lactamase-esbl-producing-escherichia-coli-and-acinetobacter-baumannii-among-horses-entering-a-veterinary-teaching-hospital-the-contemporary-trojan-horse
#18
Birgit Walther, Katja-Sophia Klein, Ann-Kristin Barton, Torsten Semmler, Charlotte Huber, Silver Anthony Wolf, Karsten Tedin, Roswitha Merle, Franziska Mitrach, Sebastian Guenther, Antina Lübke-Becker, Heidrun Gehlen
Pathogens frequently associated with multi-drug resistant (MDR) phenotypes, including extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) and Acinetobacter baumannii isolated from horses admitted to horse clinics, pose a risk for animal patients and personnel in horse clinics. To estimate current rates of colonization, a total of 341 equine patients were screened for carriage of zoonotic indicator pathogens at hospital admission. Horses showing clinical signs associated with colic (n = 233) or open wounds (n = 108) were selected for microbiological examination of nostril swabs, faecal samples and wound swabs taken from the open wound group...
2018: PloS One
https://www.readbyqxmd.com/read/29379373/antibacterial-activity-of-selected-medicinal-plants-of-northwest-pakistan-traditionally-used-against-mastitis-in-livestock
#19
Rahila Amber, Muhammad Adnan, Akash Tariq, Shahid Niaz Khan, Sakina Mussarat, Abeer Hashem, Asma A Al-Huqail, Al-Bandari Fahad Al-Arjani, Elsayed Fathi Abd Allah
The present study aimed to investigate the efficacy of traditionally used anti-mastitis plants (Allium sativum, Bunium persicum, Oryza sativa and Triticum aestivum) in northwest Pakistan against bacterial pathogens. Selected plants were phytochemically screened for Alkaloids, Flavonoids, and Saponins and checked for in vitro antibacterial activity at concentration of 50 mg/ml against S. aureus, E. coli and K. pneumoniae by agar well diffusion method. Minimum inhibitory concentration and minimum bactericidal concentration was determined against multidrug resistant bacteria using tube dilution method...
January 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29378636/traditional-uses-of-medicinal-plants-used-by-indigenous-communities-for-veterinary-practices-at-bajaur-agency-pakistan
#20
Muhammad Abdul Aziz, Amir Hasan Khan, Muhammad Adnan, Habib Ullah
BACKGROUND: The pastoral lifestyle of Indigenous communities of Bajaur Agency is bringing them close to natural remedies for treating their domestic animals. Several studies have been conducted across the globe describing the importance of traditional knowledge in veterinary care. Therefore, this study was planned with the aim to record knowledge on ethnoveterinary practices from the remote areas and share sit with other communities through published literature. METHODS: Data was gathered from community members through semi-structured interviews and analyzed through informant consensus factor (Fic) to evaluate the consent of current ethnoveterinary practices among the local people...
January 29, 2018: Journal of Ethnobiology and Ethnomedicine
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