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https://www.readbyqxmd.com/read/28535123/topical-otic-drugs-in-a-multi-purpose-manufacturing-facility-a-guide-on-determination-and-application-of-permitted-daily-exposure-pde
#1
Lisa Wiesner, Maarten Prause, Ester Lovsin Barle
Due to newly introduced EU GMP guideline for Medicinal Products for Human and Veterinary use (PIC/S, 2015), product specific PDE for toxicological evaluation in multi-purpose facilities are required within a documented process for risk assessment. EMA (2014) guidance on setting PDE limits so far focused on systemic administration routes such as IV, oral or inhalation. This manuscript wants to give guidance on setting PDE values for risk management purposes in multi-purpose facilities for Active Pharmaceutical Ingredients (APIs) applied as topical otic drugs to the outer ear canal...
May 23, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28532461/national-post-market-surveillance-assessment-of-veterinary-medicines-in-korea-during-the-past-decade
#2
JeongWoo Kang, Hae-Chul Park, Yang Ho Jang, Md Akil Hossain, Kyunghun Jeong, Mi Young Jeong, Seon-Jong Yun, Sung-Won Park, Dae Gyun Kim, Kwang-Jick Lee
BACKGROUND: Veterinary medicines have been widely used for the prevention and treatment of diseases, growth promotion, and to promote feeding efficacy in livestock. As the veterinary medicine industry has steadily grown, it is crucial to set up a baseline for the quality of medicine as well as the insufficiency or excessiveness of the active ingredients in drug products to ensure the compliance, safety and efficacy of these medicines. Thus, the 10 years data of post-marketing quality control study was summarized to determine the rate and extent of non-compliance of these medicines and to establish baseline data for future quality control measures of veterinary medicine...
May 22, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28526020/salmonella-serotypes-and-their-antimicrobial-susceptibility-in-apparently-healthy-dogs-in-addis-ababa-ethiopia
#3
Bitsu Kiflu, Haile Alemayehu, Mukarim Abdurahaman, Yohannes Negash, Tadesse Eguale
BACKGROUND: The close bond between pet animals and family members poses risk of infection with zoonotic bacterial pathogens such as Salmonella. No data is available on occurrence of Salmonella in dogs in Ethiopia. The aim of this study was therefore to determine the prevalence, serotype distribution and antimicrobial resistance of Salmonella from feces of apparently healthy dogs in Addis Ababa, Ethiopia. RESULTS: Of the total 360 dogs examined, 42 (11.7%; 95% Confidence limit of 8...
May 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28524783/quantitative-analysis-of-veterinary-drugs-in-bovine-muscle-and-milk-by-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#4
Shizuka Saito-Shida, Takatoshi Sakai, Satoru Nemoto, Hiroshi Akiyama
A simple and reliable multiresidue method for quantitative determination of veterinary drugs in bovine muscle and milk using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) was developed. Critical MS parameters such as capillary voltage, cone voltage, collision energy, desolvation gas temperature, and extraction mass window were carefully optimised to obtain the best possible sensitivity. Analytical samples were prepared using extraction with acetonitrile and hexane in the presence of anhydrous sodium sulphate and acetic acid, followed by ODS cartridge clean-up...
May 19, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28521994/double-coated-enrofloxacin-microparticles-with-chitosan-and-alginate-preparation-characterization-and-taste-masking-effect-study
#5
Mengxi Liu, Daiping Yin, Hualin Fu, Fengying Deng, Guangneng Peng, Gang Shu, Zhixiang Yuan, Fei Shi, Juchun Lin, Ling Zhao, Lizi Yin, Guoqing Fan
Enrofloxacin (ENRO) is widely used as an antimicrobial drug for treatment of uncomplicated and complicated infections in veterinary medicine. Its bitter taste limits its clinical applications in veterinary. To mask the bitter taste of this drug, double-coated taste-masking microparticles of ENRO (DTME) were prepared through stearic acid solid dispersion and chitosan-alginate microparticle coating technologies. The taste-masking effect was evaluated by pig feeding experiment. Results showed that DTME exhibited a spherical-like shape (170490μm)...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28516494/recommendations-for-approaches-to-meticillin-resistant-staphylococcal-infections-of-small-animals-diagnosis-therapeutic-considerations-and-preventative-measures-clinical-consensus-guidelines-of-the-world-association-for-veterinary-dermatology
#6
REVIEW
Daniel O Morris, Anette Loeffler, Meghan F Davis, Luca Guardabassi, J Scott Weese
BACKGROUND: Multiple drug resistance (MDR) in staphylococci, including resistance to the semi-synthetic penicillinase-resistant penicillins such as meticillin, is a problem of global proportions that presents serious challenges to the successful treatment of staphylococcal infections of companion animals. OBJECTIVES: The objective of this document is to provide harmonized recommendations for the diagnosis, prevention and treatment of meticillin-resistant staphylococcal infections in dogs and cats...
June 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28516493/diagnosis-and-treatment-of-dermatophytosis-in-dogs-and-cats-clinical-consensus-guidelines-of-the-world-association-for-veterinary-dermatology
#7
REVIEW
Karen A Moriello, Kimberly Coyner, Susan Paterson, Bernard Mignon
BACKGROUND: Dermatophytosis is a superficial fungal skin disease of cats and dogs. The most common pathogens of small animals belong to the genera Microsporum and Trichophyton. It is an important skin disease because it is contagious, infectious and can be transmitted to people. OBJECTIVES: The objective of this document is to review the existing literature and provide consensus recommendations for veterinary clinicians and lay people on the diagnosis and treatment of dermatophytosis in cats and dogs...
June 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28516409/survival-after-severe-rhabdomyolysis-following-monensin-ingestion
#8
Michela Blain, Alexander Garrard, Robert Poppenga, Betty Chen, Matthew Valento, Melissa Halliday Gittinger
INTRODUCTION: Monensin is a veterinary antibiotic with a narrow therapeutic window that has led to lethal intoxication in many animal species. Only two prior cases of human toxicity have been reported, both fatal. We present the first case of survival from severe toxicity following monensin ingestion. CASE: A 58-year-old man presented with 8 days of vomiting and abdominal pain. Due to delusions of central nervous system toxoplasmosis, he ingested 300 mg of monensin...
May 17, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28514049/canine-cutaneous-plasmacytosis-21-cases-2005-2015
#9
B O Boostrom, A S Moore, C J DeRegis, C Robat, K Freeman, D H Thamm
BACKGROUND: Cutaneous plasmacytosis (CP) is a syndrome of multiple cutaneous plasma cell tumors, in the absence of multiple myeloma. Although rare in both humans and dogs, treatment recommendations are usually extrapolated from multiple myeloma protocols. To date, no case series of CP have been described in the veterinary literature. HYPOTHESIS/OBJECTIVES: To describe clinical presentation, determine treatment response rates and duration, and report overall survival of dogs with CP...
May 17, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28514013/antimicrobial-prescribing-in-dogs-and-cats-in-australia-results-of-the-australasian-infectious-disease-advisory-panel-survey
#10
L Y Hardefeldt, S Holloway, D J Trott, M Shipstone, V R Barrs, R Malik, M Burrows, S Armstrong, G F Browning, M Stevenson
BACKGROUND: Investigations of antimicrobial use in companion animals are limited. With the growing recognition of the need for improved antimicrobial stewardship, there is urgent need for more detailed understanding of the patterns of antimicrobial use in this sector. OBJECTIVES: To investigate antimicrobial use for medical and surgical conditions in dogs and cats by Australian veterinarians. METHODS: A cross-sectional study was performed over 4 months in 2011...
May 17, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28513758/-new-drugs-for-small-animals-in-2016
#11
Ilka Ute Emmerich
In 2016, two active pharmaceutical ingredients were released on the German market for small animals: the mineralocorticoid Desoxycorticosterone (Zycortal(®)) and Sarolaner (Simparica(®)), an ectoparasiticide of the isoxazoline group. One substance has been authorized for an additional species; Fluralaner (Bravecto(®)), also an ectoparasiticide of the isoxazoline group, is now authorized for use in cats. Additionally, one veterinary drug with a new combination of active ingredients, one active substance in mono-preparation and two veterinary drugs with a new pharmaceutical form have been launched on the market for small animals...
May 17, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28513757/-new-drugs-for-horses-and-production-animals-in-2016
#12
Ilka Ute Emmerich
In 2016, only one newly developed active pharmaceutical ingredient for horses and food-producing animals was released on the German market for veterinary drug products. The immunomodulator Pegbovigrastim is now available as an injection solution for cattle (Imrestor(®)). Four established veterinary active pharmaceutical ingredients are available for further species: the ectoparasitic Amitraz (Apitraz(®)) from the triazapentadiene group was additionally authorized for honeybees, the expectorant Bromhexine (Exflow(®) Vet) for chickens, turkeys and ducks and the macrolide antibiotic Gamithromycin (Zactran(®)) for pigs...
May 17, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28512231/survey-on-antimicrobial-prescribing-patterns-in-small-animal-veterinary-practice-in-emilia-romagna-italy
#13
A Barbarossa, J Rambaldi, V Miraglia, M Giunti, G Diegoli, A Zaghini
This investigation provides for the first time a general view of the prescribing patterns of antimicrobials in small animal practice in Emilia Romagna, Italy. In the context of a project on antimicrobial resistance managed by the Regional Veterinary Service, veterinary clinicians were invited to voluntarily complete an online questionnaire. This was designed to gather information on antimicrobial prescribing practices and biosecurity measures and to understand the perception of the issue specific to this region of Italy...
May 16, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28498966/genprobis-web-server-for-mapping-of-sequence-variants-to-protein-binding-sites
#14
Janez Konc, Blaz Skrlj, Nika Erzen, Tanja Kunej, Dusanka Janezic
Discovery of potentially deleterious sequence variants is important and has wide implications for research and generation of new hypotheses in human and veterinary medicine, and drug discovery. The GenProBiS web server maps sequence variants to protein structures from the Protein Data Bank (PDB), and further to protein-protein, protein-nucleic acid, protein-compound, and protein-metal ion binding sites. The concept of a protein-compound binding site is understood in the broadest sense, which includes glycosylation and other post-translational modification sites...
May 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28479392/relationship-between-ivermectin-concentrations-at-the-injection-site-muscle-and-fat-of-steers-treated-with-traditional-and-long-acting-preparations
#15
Sebastian Iezzi, Peter Purslow, Christensen Sara, Carlos Lanusse, Adrian Lifschitz
Ivermectin (IVM) is broad-spectrum compound active against endo and ecto-parasites of clinical relevance in veterinary and human medicine. It is commercially available to use in livestock animals as injectable formulations containing 1% IVM and also as a concentrated (3.15%) long-acting (LA) preparation. The potential risk of the presence of high concentrations of drug residues in muscle tissue at the injection site is therefore a concern. The aim of this study was to determine the relationship between the IVM residual concentrations at the injection site, in comparison to the untreated contralateral neck (control muscle) and in fat from cattle treated with different preparations...
May 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28472586/development-and-validation-of-a-multiclass-multiresidue-method-for-veterinary-drug-analysis-in-infant-formula-and-related-ingredients-using-uhplc-ms-ms
#16
Hui Zhao, John Zulkoski, Katerina Mastovska
A multiclass, multiresidue method based on ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) has been developed and validated for the analysis of around 150 veterinary drugs in infant formula and related dairy ingredients. The included analytes belong to the following veterinary drug classes: anthelmintics, antibiotics (aminoglycoside, amphenicols, β-lactams-penicillins and cephalosporins, lincosamides, macrolides, quinolones, sulfonamides, tetracyclines, and others), antimicrobial growth promoters, antiprotozoals, β-agonists, coccidiostats, dyes, pesticides, and tranquilizers...
May 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28462039/oxytetracycline-induces-dna-damage-and-epigenetic-changes-a-possible-risk-for-human-and-animal-health
#17
Adriana Gallo, Rosaria Landi, Valentina Rubino, Alessandro Di Cerbo, Angela Giovazzino, Anna Teresa Palatucci, Sara Centenaro, Gianandrea Guidetti, Sergio Canello, Laura Cortese, Giuseppina Ruggiero, Andrea Alessandrini, Giuseppe Terrazzano
BACKGROUND: Oxytetracycline (OTC), which is largely employed in zootechnical and veterinary practices to ensure wellness of farmed animals, is partially absorbed within the gastrointestinal tract depositing in several tissues. Therefore, the potential OTC toxicity is relevant when considering the putative risk derived by the entry and accumulation of such drug in human and pet food chain supply. Despite scientific literature highlights several OTC-dependent toxic effects on human and animal health, the molecular mechanisms of such toxicity are still poorly understood...
2017: PeerJ
https://www.readbyqxmd.com/read/28458414/veterinary-pharmacovigilance-in-india-a-need-of-hour
#18
Rishi Kumar, Vivekanandan Kalaiselvan, Ravendra Verma, Ismeet Kaur, Pranay Kumar, G N Singh
Veterinary pharmacovigilance (PV) is important for the Medicine which are used for treating disease in animals. It becomes more important when these animals are further used for producing food. Adverse drug reactions (ADRs) have a direct impact on animals and indirect impact on human beings, for example, through milk products, other animal producing food products. Currently, PV program of India is playing a vital role in assessing the safety of medicines in Indian Population. The safety of medicine in animals can be assessed by veterinary PV...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28455852/practical-application-of-in-silico-fragmentation-based-residue-screening-with-ion-mobility-high-resolution-mass-spectrometry
#19
Anton Kaufmann, Patrick Butcher, Kathry Maden, Stephan Walker, Mirjam Widmer
RATIONALE: A screening concept for residues in complex matrices based on liquid chromatography coupled to ion mobility-high resolution mass spectrometry LC-IMS-HRMS is presented. The comprehensive four dimensional data (chromatographic retention time, drift time, mass to charge and ion abundance) obtained in data independent (DIA) acquisition mode was used for data mining. An in silico fragmenter utilizing a molecular structure database was used for suspect screening, instead of targeted screening with reference substances...
April 29, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28454589/prevalence-and-antimicrobial-resistance-profile-of-staphylococcus-in-dairy-farms-abattoir-and-humans-in-addis-ababa-ethiopia
#20
Takele Beyene, Halefom Hayishe, Fikru Gizaw, Ashenafi Feyisa Beyi, Fufa Abunna, Bedaso Mammo, Dinka Ayana, Hika Waktole, Reta Duguma Abdi
BACKGROUND: Staphylococcus species cause mastitis and wound infection in livestock and food poisoning in humans through ingestion of contaminated foods, including meat and dairy products. They are evolving pathogens in that they readily acquire drug resistance, and multiple drug-resistant (MDR) isolates are increasing in human and veterinary healthcare. Therefore, this study was conducted to evaluate the prevalence of Staphylococci and their drug resistance in dairy farms and abattoir settings of Addis Ababa...
April 28, 2017: BMC Research Notes
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