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https://www.readbyqxmd.com/read/29027350/liposome-encapsulated-chemotherapy-current-evidence-for-its-use-in-companion-animals
#1
REVIEW
B Børresen, A E Hansen, A Kjaer, T L Andresen, A T Kristensen
Cytotoxic drugs encapsulated into liposomes were originally designed to increase the anticancer response, while minimizing off-target adverse effects. The first liposomal chemotherapeutic drug was approved for use in humans more than 20 years ago, and the first publication regarding its use in a canine cancer patient was published shortly thereafter. Regardless, no general application for liposomal cytotoxic drugs has been established in veterinary oncology till now. Due to the popularity of canines as experimental models for pharmacokinetic analyses and toxicity studies, multiple publications exist describing various liposomal drugs in healthy dogs...
October 13, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29018532/real-world-data-of-a-veterinary-teaching-hospital-in-japan-a-pilot-survey-of-prescribed-medicines
#2
Noriko Tanaka, Tsuyoshi Takizawa, Nao Miyamoto, Shinji Funayama, Ryo Tanaka, Syozo Okano, Toshio Iwasaki
The prescription data from a digital accounting system of a veterinary teaching hospital collected between 2008 and 2011 in Japan were downloaded, stored in a database and analysed using a statistical analysis software, SAS. Seventy-six per cent of all prescriptions were drugs approved for human beings. The most frequently prescribed category was 'Agents against pathogenic organisms', such as antibiotics and chemotherapeutic agents, followed by 'Cardiovascular agents'. Seventy-five per cent of prescribed oral formulations in the category 'Agents against pathogenic organisms' were drugs approved for human beings, while 78 per cent of the injectable prescriptions were those for veterinary...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/28992489/methotrexate-induces-high-level-of-apoptosis-in-canine-lymphoma-leukemia-cell-lines
#3
Aleksandra Pawlak, Justyna Kutkowska, Bożena Obmińska-Mrukowicz, Andrzej Rapak
INTRODUCTION: Methotrexate is an antimetabolite used in the treatment of cancer and non-malignant diseases including rheumatoid arthritis, psoriasis and graft vs. host disease. Combination therapy with methotrexate was successful in the treatment of canine lymphoma, mammary tumor and invasive urinary bladder cancer. Lymphoma, the most common hematopoietic cancer in dogs, and leukemia are sensitive to chemotherapy, which is why methotrexate may be an important treatment option for these diseases...
September 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28985539/the-use-of-toxicokinetics-and-exposure-studies-to-show-that-carprofen-in-cattle-tissue-could-lead-to-secondary-toxicity-and-death-in-wild-vultures
#4
V Naidoo, M A Taggart, N Duncan, K Wolter, J Chipangura, R E Green, T H Galligan
Veterinary medicines can be extremely damaging to the environment, as seen with the catastrophic declines in Gyps vulture in South Asia due to their secondary exposure to diclofenac in their primary food source. Not surprisingly, concern has been raised over other similar drugs. In this study, we evaluate the toxicity of carprofen to the Gyps vulture clade through plasma pharmacokinetics evaluations in Bos taurus cattle (their food source) and Gyps africanus (a validated model species); tissue residues in cattle; and the effect of carprofen as a secondary toxicant as both tissue-bound residue or pure drug at levels expected in cattle tissues...
September 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28968193/mechanism-of-neonicotinoid-toxicity-impact-on-oxidative-stress-and-metabolism
#5
Xu Wang, Arturo Anadón, Wu Qinghua, Fang Qiao, Irma Ares, María-Rosa Martínez-Larrañaga, Zonghui Yuan, María-Aránzazu Martínez
Thousands of tons of neonicotinoids are widely used around the world as broad-spectrum systemic insecticides and veterinary drugs. Researchers originally thought that neonicotinoids exhibited low mammalian toxicity. However, following their widespread use, it became increasingly evident that neonicotinoids could have various toxic effects on vertebrates and invertebrates. The primary focus of this review is to summarize the research progress associated with oxidative stress as a plausible mechanism for neonicotinoid-induced toxicity as well as neonicotinoid metabolism...
October 2, 2017: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28967825/evaluation-of-drug-content-potency-for-compounded-and-fda-approved-formulations-of-doxycycline-on-receipt-and-after-21-days-of-storage
#6
Kate KuKanich, Butch KuKanich, Tanner Slead, Matt Warner
OBJECTIVE To determine drug content (potency) of compounded doxycycline formulations for veterinary use and of US FDA-approved doxycycline formulations for human use < 24 hours after receipt (day 1) and after 21 days of storage under recommended conditions (day 21). DESIGN Evaluation study. SAMPLE FDA-approved doxycycline tablets (100 mg), capsules (100 mg), and liquid suspension (10 mg/mL) and compounded doxycycline formulations from 3 pharmacies (tablets [25, 100, and 150 mg; 1 product/source], chews [100 mg; 1 product/source], and liquid suspensions or solution [6 mg/mL {2 sources} and 50 mg/mL {1 source}])...
October 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28967824/outcome-following-inhalation-anesthesia-in-birds-at-a-veterinary-referral-hospital-352-cases-2004-2014
#7
Amanda B Seamon, Erik H Hofmeister, Stephen J Divers
OBJECTIVE To determine the outcome in birds undergoing inhalation anesthesia and identify patient or procedure variables associated with an increased likelihood of anesthesia-related death. DESIGN Retrospective case series. ANIMALS 352 birds that underwent inhalation anesthesia. PROCEDURES Medical records of birds that underwent inhalation anesthesia from January 1, 2004, through December 31, 2014, at a single veterinary referral hospital were reviewed. Data collected included date of visit, age, species, sex, type (pet, free ranging, or wild kept in captivity), body weight, body condition score, diagnosis, procedure, American Society of Anesthesiologists status, premedication used for anesthesia, drug for anesthetic induction, type of maintenance anesthesia, route and type of fluid administration, volumes of crystalloid and colloid fluids administered, intraoperative events, estimated blood loss, duration of anesthesia, surgery duration, recovery time, recovery notes, whether birds survived to hospital discharge, time of death, total cost of hospitalization, cost of anesthesia, and nadir and peak values for heart rate, end-tidal partial pressure of carbon dioxide, concentration of inhaled anesthetic, and body temperature...
October 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28952960/-antibioticscout-ch-a-decision-supporting-tool-for-antimicrobial-stewardship-application-to-companion-animal-medicine
#8
R Peter, D Demuth, C Müntener, M Lampart, D Heim, M Mevissen, G Schüpbach-Regula, S Schuller, F Stucki, B Willi, W Burkhardt, T Francey, C Nett, F Tschuor, H Naegeli
Bacterial resistances to antimicrobial drugs pose serious public health challenges. The observed increase of resistances is attributed to the uncontrolled, massive and often unnecessary administration of antibiotics both in human and veterinary medicine. To support the responsible use of antimicrobials in animals and help veterinarians selecting the most suitable antimicrobial drugs, we developed the AntibioticScout.ch as a comprehensive decision supporting tool providing online access to the current knowledge of rational antibiotic prescription practices...
October 2017: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/28951481/bacterial-whack-a-mole-reconsidering-the-public-health-relevance-of-using-carbadox-in-food-animals
#9
Lance B Price
Carbadox is an antibiotic used to control dysentery and promote growth in swine in the United States; however, the drug also causes tumors and birth defects in laboratory animals. Despite this and because the drug has no analogs in human medicine, it is not considered "medically important" and can be used in livestock without veterinarian oversight. In their recent study, T. A. Johnson et al. (mBio 8:e00709-17, 2017, https://doi.org/10.1128/mBio.00709-17) demonstrated that carbadox has profound effects on the swine gut microbiome, including the induction of transducing phage carrying tetracycline, aminoglycoside, and beta-lactam resistance genes...
September 26, 2017: MBio
https://www.readbyqxmd.com/read/28948625/survey-of-systemic-antimicrobial-prescribing-for-dogs-by-victorian-veterinarians
#10
I D Barzelai, T Whittem
OBJECTIVE: Investigate the current antimicrobial prescribing patterns of veterinarians in Victoria for dogs and compare these results to patterns described 20 years ago. METHODS: A questionnaire was sent to 1380 veterinarians in Victoria. The first section collected demographic information of respondents. The second and third sections evaluated respondents' approach to use of antimicrobial drugs for scenarios in dogs in which 'clinical evidence suggests bacterial infection is the likely cause' and where 'it is unknown whether bacterial infection plays a role'...
October 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28946249/chitosan-from-shrimp-shells-a-renewable-sorbent-applied-to-the-clean-up-step-of-the-quechers-method-in-order-to-determine-multi-residues-of-veterinary-drugs-in-different-types-of-milk
#11
Jean Lucas de Oliveira Arias, Antunielle Schneider, Jahir Antonio Batista-Andrade, Augusto Alves Vieira, Sergiane Souza Caldas, Ednei Gilberto Primel
Clean extracts are essential in LC-MS/MS, since the matrix effect can interfere in the analysis. Alternative materials which can be used as sorbents, such as chitosan in the clean-up step, are cheap and green options. In this study, chitosan from shrimp shell waste was evaluated as a sorbent in the QuEChERS method in order to determine multi-residues of veterinary drugs in different types of milk, i. e., fatty matrices. After optimization, the method showed correlation coefficients above 0.99, LOQs ranged between 1 and 50μgkg(-1) and recoveries ranged between 62 and 125%, with RSD<20% for all veterinary drugs in all types of milk under study...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28941404/development-of-a-simple-multi-residue-determination-method-of-80-veterinary-drugs-in-oplegnathus-punctatus-by-liquid-chromatography-coupled-to-quadrupole-orbitrap-mass-spectrometry
#12
Fei Zhao, Xin Gao, Zhixu Tang, Xin Luo, Miaomiao Wu, Jiachao Xu, Xiaoting Fu
A simple, rapid and sensitive multi-residue analytical method was developed and validated for 80 veterinary drugs in Oplegnathus punctatus using ultrahigh performance liquid chromatography-Orbitrap high resolution mass spectrometry (LC-HRMS). The analytes belong to 12 different families include benzimidazoles, β-lactams, lincosamides, macrolides, nitromidazoles, quinolones, sulfonamides and trimethoprim, tetracyclines, triphenylmethane dyes, amphenicols, nonsteroidal estrogens and steroid hormones. The sample preparation was optimized base on QuEChERS (quick, easy, cheap, effective, rugged and safe) procedure...
September 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28934348/antimicrobial-resistance-in-clinical-escherichia-coli-isolates-from-poultry-and-livestock-china
#13
Afrah Kamal Yassin, Jiansen Gong, Patrick Kelly, Guangwu Lu, Luca Guardabassi, Lanjing Wei, Xiangan Han, Haixiang Qiu, Stuart Price, Darong Cheng, Chengming Wang
Poultry and livestock are the most important reservoirs for pathogenic Escherichia coli and use of antimicrobials in animal farming is considered the most important factor promoting the emergence, selection and dissemination of antimicrobial-resistant microorganisms. The aim of our study was to investigate antimicrobial resistance in E. coli isolated from food animals in Jiangsu, China. The disc diffusion method was used to determine susceptibility to 18 antimicrobial agents in 862 clinical isolates collected from chickens, ducks, pigs, and cows between 2004 and 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28929472/-ivermectin-as-an-adjunct-in-the-treatment-of-refractory-epilepsy
#14
J A Diazgranados-Sanchez, J L Mejia-Fernandez, L S Chan-Guevara, M H Valencia-Artunduaga, J L Costa
INTRODUCTION: Ivermectin, a 22'23 dihydro derivative of avermectins beta-1a, is a highly effective veterinary and human anti parasitic, used to treat endoparasites of difficult control such as filariasis and onchocerciasis, with a median plasma life of at least of 16 hours. The recommended therapeutic doses range from 0.05 to 0.40 mg/kg, without undesirable effects or risk to human life. It went from being a great success in animal health to its application in humans, where it has had great impact...
October 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28929103/authorization-and-toxicity-of-veterinary-drugs-and-plant-protection-products-residues-of-the-active-ingredients-in-food-and-feed-and-toxicity-problems-related-to-adjuvants
#15
REVIEW
Szandra Klátyik, Péter Bohus, Béla Darvas, András Székács
Chemical substances applied in animal husbandry or veterinary medicine and in crop protection represent substantial environmental loads, and their residues occur in food and feed products. Product approval is governed differently in these two sectors in the European Union (EU), and the occurrence of veterinary drug (VD) and pesticide residues indicated by contamination notification cases in the Rapid Alert System for Food and Feed of the EU also show characteristic differences. While the initial high numbers of VD residues reported in 2002 were successfully suppressed to less than 100 cases annually by 2006 and on, the number of notification cases for pesticide residues showed a gradual increase from a low (approximately 50 cases annually) initial level until 2005 to more than 250 cases annually after 2009, with a halt occurring only in 2016...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28929096/contaminants-in-foods-of-animal-origin-in-cameroon-a-one-health-vision-for-risk-management-from-farm-to-fork
#16
REVIEW
Guy B Pouokam, B U Saha Foudjo, Chi Samuel, Philomina Fankam Yamgai, A Kamda Silapeux, Joel Taguemkam Sando, G Fankam Atonde, Chiara Frazzoli
Foods of animal origin represent an important share in the diet of Cameroonian populations. Cameroon is known to be a food basket in the west and central Africa sub-region, and an important supplier of foods on the international markets. In the meantime, food importation is continuously increasing to meet the high demand of a more westernized segment of the population. Cereals, fish, sea products, eggs, honey, shrimps, chicken, and feed ingredients are important share in the international trade of agricultural products...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28926584/transcriptome-analysis-reveals-molecular-anthelmintic-effects-of-procyanidins-in-c-elegans
#17
Verena Spiegler, Andreas Hensel, Jochen Seggewiß, Milena Lubisch, Eva Liebau
Worldwide, more than 1 billion people are affected by infestations with soil-transmitted helminths and also in veterinary medicine helminthiases are a severe threat to livestock due to emerging resistances against the common anthelmintics. Proanthocyanidins have been increasingly investigated for their anthelmintic properties, however, except for an interaction with certain proteins of the nematodes, not much is known about their mode of action. To investigate the anthelmintic activity on a molecular level, a transcriptome analysis was performed in Caenorhabditis elegans after treatment with purified and fully characterized oligomeric procyanidins (OPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28926014/assessing-the-economic-impact-of-an-endemic-disease-the-case-of-mastitis
#18
H Hogeveen, M Van Der Voort
A large part of the world's resources are used to produce animal products. Efficient use of these resources is important to improve social well-being. Endemic animal diseases decrease production efficiency, because they require a higher level of input to produce the same amount of output or result in a lower output with the same amount of input. The optimal level of production with and without disease differs from farm to farm and depends on varying economic circumstances. Given these difficulties, making an accurate theoretical estimation of the economic impact of endemic diseases is challenging...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28917299/exploitation-of-chemical-herbal-and-nanoformulated-acaricides-to-control-the-cattle-tick-rhipicephalus-boophilus-microplus-a-review
#19
REVIEW
Balan Banumathi, Baskaralingam Vaseeharan, Periyannan Rajasekar, Narayanan Marimuthu Prabhu, Palaniappan Ramasamy, Kadarkarai Murugan, Angelo Canale, Giovanni Benelli
The tick Rhipicephalus (Boophilus) microplus is a key vector of bacterial and protozoan diseases causing heavy economic losses directly and indirectly in animal husbandry. In the past decades, the control of ticks faced some major issues, such as the rapid development of resistance in targeted vectors and non-target effects on human health and the environment, due to the employ of synthetic acaricides and repellents. Eco-friendly pesticides for treating and controlling animal parasites such as ticks were mainly from medicinal plants and thus they form the richest entity for manufacturing resources for drugs...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28916690/suspect-drug-interaction-in-gimmers
#20
(no author information available yet)
Suspect serious adverse event associated with vaccination in gimmersMultiple congenital defects in a stillborn calfSuspected alpha mannosidosis in a bovine fetusClostridial myocarditis in a two-week-old lambOtitis media in pigs These are among matters discussed in the disease surveillance report for May 2017 from SAC Consulting: Veterinary Services (SAC C VS).
September 16, 2017: Veterinary Record
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