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https://www.readbyqxmd.com/read/29458198/adverse-childhood-experiences-and-adult-inflammation-findings-from-the-1958-british-birth-cohort
#1
Mingyi Chen, Rebecca E Lacey
BACKGROUND: The relationship between adverse childhood experiences (ACE) and poorer health across the life course is well established. Increased chronic inflammation might be one mechanism through which these associations operate. The aim of this study was to explore the relationship between ACE and adult inflammation using a prospective longitudinal study. We also investigated whether associations were explained by life course socioeconomic, psychological and health behavioural factors, and whether associations differed by gender...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29458196/within-subject-associations-between-inflammation-and-features-of-depression-using-the-flu-vaccine-as-a-mild-inflammatory-stimulus
#2
Kate R Kuhlman, Theodore F Robles, Larissa N Dooley, Chloe C Boyle, Marcie D Haydon, Julienne E Bower
BACKGROUND: Inflammation plays a role in mood and behavior that may be relevant to identifying risk factors and treatment for depression and other stress-related illnesses. The purpose of this study was to examine whether fluctuations in inflammation following a mild immune stimulus were associated with changes in daily reported features of depression for up to a week in a healthy sample of young adults. METHODS: Forty one undergraduate students completed daily diaries of mood, feelings of social disconnection, sleep, and physical symptoms for one week before and after receiving the seasonal influenza vaccine...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29458194/differential-effects-of-acute-versus-chronic-stress-on-ethanol-sensitivity-evidence-for-interactions-on-both-behavioral-and-neuroimmune-outcomes
#3
Tamara L Doremus-Fitzwater, Jacqueline E Paniccia, Anny Gano, Andrew Vore, Terrence Deak
Acute alcohol intoxication induces significant alterations in brain cytokines. Since stress challenges also profoundly impact central cytokine expression, these experiments examined the influence of acute and chronic stress on ethanol-induced brain cytokine responses. In Experiment 1, adult male rats were exposed to acute footshock. After a post-stress recovery interval of 0, 2, 4, or 24 h, rats were administered ethanol (4 g/kg; intragastric), with trunk blood and brains collected 3 h later. In non-stressed controls, acute ethanol increased expression of Il-6 and IκBα in the hippocampus...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29458150/pink1-protects-auditory-hair-cells-and-spiral-ganglion-neurons-from-cisplatin-induced-ototoxicity-via-inducing-autophagy-and-inhibiting-jnk-signaling-pathway
#4
Qianqian Yang, Gaoying Sun, Haiyan Yin, Hongrui Li, Zhixin Cao, Jinghan Wang, Meijuan Zhou, Haibo Wang, Jianfeng Li
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 (PINK1) gene encodes a serine/threonine kinase, which acts as a molecular sensor of mitochondrial health necessary for mitochondrial quality control. The present study was designed to examine whether PINK1 expressed in C57BL/6 murine cochlea and HEI-OC1 cells and, if so, to investigate the possible mechanisms underlying the action of PINK1 in cisplatin-induced death of sensory hair cells (HCs) and spiral ganglion neurons (SGNs) in vitro. The expression pattern of PINK1, formation of parkin particles, and autophagy were determined by immunofluorescent staining...
February 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29458107/wnt-receptor-signalling-in-lung-physiology-and-pathology
#5
REVIEW
Wioletta Skronska-Wasek, Reinoud Gosens, Melanie Königshoff, Hoeke Abele Baarsma
The WNT signalling cascades have emerged as critical regulators of a wide variety of biological aspects involved in lung development as well as in physiological and pathophysiological processes in the adult lung. WNTs (secreted glycoproteins) interact with various transmembrane receptors and co-receptors to activate signalling pathways that regulate transcriptional as well as non-transcriptional responses within cells. In physiological conditions, the majority of WNT receptors and co-receptors can be detected in the adult lung...
February 16, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29458098/spermine-protects-from-lps-induced-memory-deficit-via-bdnf-and-trkb-activation
#6
Pâmella K Frühauf-Perez, Fernanda R Temp, Micheli M Pillat, Cristiane Signor, Arithane Lorena Wendel, Henning Ulrich, Carlos F Mello, Maribel A Rubin
Lipopolysaccharide (LPS) has been long known to promote neuroinflammation and learning and memory deficits. Since spermine, one of the main natural polyamines in the central nervous system, protects from LPS-induced memory deficit by a mechanism that comprises GluN2B receptors, the aim of the present study was to determine whether brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB) receptor and cAMP response element binding (CREB) are involved in this protective effect of spermine...
February 16, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29458088/antibiotics-use-among-palestine-refugees-attending-unrwa-primary-health-care-centers-in-jordan-a-cross-sectional-study
#7
Maysun Al Baz, Michael R Law, Rawan Saadeh
The irrational use of antibiotics is increasing in Jordanian refugee camps and consequently so too is bacterial resistance. About one-third of health expenditures at UNRWA health centers in Jordan are attributed to antibiotics. OBJECTIVE: We studied knowledge, attitude and behaviour of Palestine refugees attending UNRWA health centers in Jordan regarding antibiotic use in order to plan public health interventions accordingly. METHODS: A cross-sectional, interviewer-administered survey among 250 adult Palestine refugees at four different health centres was conducted...
February 16, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29458081/di-2-ethylhexyl-phthalate-dehp-alters-proliferation-and-uterine-gland-numbers-in-the-uteri-of-adult-exposed-mice
#8
Kadeem A Richardson, Patrick R Hannon, Yvette J Johnson-Walker, Maung Sun Myint, Jodi A Flaws, Romana A Nowak
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that has been shown to impair normal reproductive function in males and females. This study investigated whether adult exposure to environmental and occupational doses of DEHP alters homeostasis of uterine proliferation, morphology, and number of uterine glands. Adult female CD1 mice were orally dosed with DEHP (0, 20 μg/kg/day, 200 μg/kg/day, 20 mg/kg/day or 200 mg/kg/day) for 30 days. Results indicated that DEHP at 200 μg/kg/day caused a reduction in epithelial cell proliferation in the uterus (p < ...
February 16, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29458075/lateral-inhibition-in-the-autism-spectrum-an-ssvep-study-of-visual-cortical-lateral-interactions
#9
Abigail Dickinson, Rosanna Gomez, Myles Jones, Vance Zemon, Elizabeth Milne
Circuit level brain dysfunction has been suggested as a common mechanism through which diverse genetic risk factors and neurobiological sequelae lead to the core features of autism spectrum disorder (Geschwind 2009; Port et al. 2014). An important mediator of circuit level brain activity is lateral inhibition, and a number of authors have suggested that lateral inhibition may be atypical in ASD. However, evidence regarding putative atypical lateral connections in ASD is mixed. Here we employed a steady state visual evoked potential (SSVEP) paradigm to further investigate lateral connections within a group of high functioning adults with ASD...
February 16, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29458072/influence-of-xenorhabdus-gamma-proteobacteria-enterobacteriaceae-symbionts-on-gonad-postembryonic-development-in-steinernema-nematoda-steinernematidae-nematodes
#10
Alexandra C Roder, S Patricia Stock
Steinernema nematodes and their Xenorhabdus partners form an obligate mutualistic association. This partnership is insecticidal to a wide range of insects. Steinernema rely on their Xenorhabdus partner to produce toxins inside the insect cadaver to liberate nutrients from the insect, as well as antimicrobials to sterilize the cadaver, thus creating a suitable environment for reproduction. In return, Steinernema vector their Xenorhabdus between insect hosts. Disruption of this partnership may affect the success of both partners...
February 16, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29458059/modest-enhancement-of-sensory-axon-regeneration-in-the-sciatic-nerve-with-conditional-co-deletion-of-pten-and-socs3-in-the-dorsal-root-ganglia-of-adult-mice
#11
Zachary R Gallaher, Oswald Steward
Axons within the peripheral nervous system are capable of regeneration, but full functional recovery is rare. Recent work has shown that conditional deletion of two key signaling inhibitors of the PI3K and Jak/Stat pathways-phosphatase and tensin homolog (PTEN) and suppressor of cytokine signaling-3 (SOCS3), respectively-promotes regeneration of normally non-regenerative central nervous system axons. Moreover, in studies of optic nerve regeneration, co-deletion of both PTEN and SOCS3 has an even greater effect...
February 16, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29458053/circulating-bile-acids-in-healthy-adults-respond-differently-to-a-dietary-pattern-characterized-by-whole-grains-legumes-and-fruits-and-vegetables-compared-to-a-diet-high-in-refined-grains-and-added-sugars-a-randomized-controlled-crossover-feeding-study
#12
Bigina N R Ginos, Sandi L Navarro, Yvonne Schwarz, Haiwei Gu, Dongfang Wang, Timothy W Randolph, Ali Shojaie, Meredith A J Hullar, Paul D Lampe, Mario Kratz, Marian L Neuhouser, Daniel Raftery, Johanna W Lampe
OBJECTIVE: The effects of diets high in refined grains on biliary and colonic bile acids have been investigated extensively. However, the effects of diets high in whole versus refined grains on circulating bile acids, which can influence glucose homeostasis and inflammation through activation of farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5), have not been studied. MATERIALS AND METHODS: We conducted a secondary analysis from a randomized controlled crossover feeding trial (NCT00622661) in 80 healthy adults (40 women/40 men, age 18-45 years) from the greater Seattle Area, half of which were normal weight (BMI 18...
February 16, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29457997/detection-of-acute-and-long-term-effects-of-concussion-dual-task-gait-balance-control-vs-computerized-neurocognitive-test
#13
David R Howell, Louis R Osternig, Li-Shan Chou
OBJECTIVE: Our aim was to examine the acute (within 72 hours of injury) and long-term (2 months post-injury) independent associations between objective dual-task gait balance and neurocognitive measurements among adolescents and young adults with a concussion and matched controls. DESIGN: Longitudinal case-control SETTING: Motion analysis laboratory PARTICIPANTS: Participants who sustained a concussion underwent a dual-task gait analysis and computerized neurocognitive testing within 72 hours of injury and again 2 months later...
February 16, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29457995/validation-of-a-brazilian-portuguese-version-of-the-transition-readiness-assessment-questionnaire-traq-in-a-population-of-transitional-youth-with-chronic-rheumatologic-disorders
#14
Catherine G Anelli, Claudio A Len, Maria T Terreri, Gleice C S Russo, Andreas O Reiff
OBJECTIVE: To translate and validate the Brazilian Portuguese version of the Transition Readiness Assessment Questionnaire in a population of adolescents and young adults with chronic rheumatologic disorders. This questionnaire evaluates the patient's readiness for making the transition from the pediatric health service to adult care. METHODS: The four-phase methodology for the translation and validation of generic questionnaires was followed, including translation, back-translation, pilot testing and clinical validation of the final tool...
February 16, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29457960/phylogenetic-relationships-and-acaricidal-effects-of-beauveria-bassiana-obtained-from-cattle-farm-soils-against-rhipicephalus-microplus
#15
Agustin Fernández-Salas, Miguel Angel Alonso Díaz, Rogelio Alejandro Alonso Morales, Roberto Lezama-Gutierrez, José Antonio Cervantes-Chávez
The objectives of the present study were to isolate Beauveria bassiana strains from cattle farms soils, to analyze the phylogenetic relationships among the isolated fungi strains, and to determine the acaricidal effect of B. bassiana isolates on Rhipicephalus microplus engorged ticks, resistant or susceptible to chemical acaricides. Six strains of Beauveria bassiana were obtained and isolated from cattle farms soils by Galleria bait method in Mexican tropics and the acaricidal effect was assessed against 2 populations of R...
February 19, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29457936/prevalence-structure-and-distribution-of-novel-parasite-cysts-containing-dracunculus-species-in-river-otters-lontra-canadensis-from-arkansas
#16
Renn Tumlison, Allison Surf
Adult female Guinea worms (Dracunculus spp.) usually are reported to occur singly in the extremities of their hosts, from which they deliver their larvae through fistulae in the host's skin into the water. We visually examined for presence of worms in the fascia of the limbs of skinned carcasses of 184 river otters (Lontra canadensis) harvested in Arkansas, and report observations of cysts on wrists and ankles found on 12 otters. Cysts averaged 15.6 X 24.6 mm in size, were round to oval, and contained masses of up to 19 adult female Dracunculus sp...
February 19, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29457932/oral-health-related-outcomes-in-edentulous-patients-treated-with-mandibular-implant-retained-dentures-versus-complete-dentures-systematic-review-with-meta-analyses
#17
Philip Kroll, Lisa Hou, Hani Radaideh, Nazanin Sharifi, Phuu P Han, Roseann Mulligan, Reyes Enciso
The objective of this systematic review was to determine the effect on oral health-related outcomes from mandibular implant-retained dentures opposing maxillary complete dentures in edentulous middle-age and older adults compared to complete removable dentures in both arches. Randomized controlled trials with an average age of the participants being 65 years old or above were included. The Cochrane Library, MEDLINE and Web of Science were searched. A total of 228 abstracts were reviewed for inclusion criteria with fourteen trials included and analyzed for risk of bias...
February 19, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29457924/factors-influencing-audiologists-perception-of-moral-climate-in-the-workplace
#18
Andrea Simpson, Kendall Phillips, Danny Wong, Sandy Clarke, Michelle Thornton
OBJECTIVE: The purpose of this study was to assess audiologists' perceptions of ethics and moral climate in the workplace. DESIGN: The Ethics Environmental Questionnaire (EEQ) was sent out to all audiologists registered with the professional body Audiology Australia. Participants were also invited to undertake a semi-structured interview. STUDY SAMPLE: A total of 301 audiologists completed the questionnaire. Eight of these participants also agreed to complete the interview...
February 19, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29457912/decreased-resting-gamma-activity-in-adult-attention-deficit-hyperactivity-disorder
#19
László Tombor, Brigitta Kakuszi, Szilvia Papp, János Réthelyi, István Bitter, Pál Czobor
OBJECTIVES: To delineate task-free gamma activity in adult ADHD and healthy control subjects based on high-density EEG recordings. Relationship of gamma activity with symptom severity was also examined, since gamma activity is considered as an index of network functions in the brain that underlie higher-order cognitive processes. METHODS: Spontaneous-EEG was recorded in adult ADHD subjects (N = 42;25 methylphenidate-naïve and 17 on methylphenidate treatment) and controls (N = 59) with eyes open...
February 19, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29457875/variations-of-the-circle-of-willis-at-the-end-of-the-human-embryonic-period
#20
Kana Furuichi, Aoi Ishikawa, Chigako Uwabe, Haruyuki Makishima, Shigehito Yamada, Tetsuya Takakuwa
Variations of the circle of Willis (CW) influence blood supply to the brain and adjacent structures in adults. We examined the formation of the CW in 20 human embryo samples at the end of the embryonic period using 3-D reconstructions of serial histological sections. The CW was closed in all samples, and did not form in a single plane, but was composed of multiple stair-like planes. The artery acutely curved at the caudal part of the CW, namely at the inlet of the basilar artery and bifurcation of the P1 segment of the posterior cerebral artery (PCA), reflecting flexure of the mesencephalon and diencephalon at this stage...
February 19, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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