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https://www.readbyqxmd.com/read/28088808/shunt-surgery-in-idiopathic-intracranial-hypertension-aided-by-electromagnetic-navigation
#1
Elvis J Hermann, Manolis Polemikos, Hans E Heissler, Joachim K Krauss
BACKGROUND: Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure and normal or slit ventricles. Lumboperitoneal shunting had been favored by many investigators for CSF diversion in IIH for decades; however, it has been associated with various side effects. Because of the small ventricular size adequate positioning of a ventricular catheter is challenging. OBJECTIVES: Here, we investigated the usefulness of electromagnetic (EM)-guided ventricular catheter placement for ventriculoperitoneal shunting in IIH...
January 14, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28088807/posterior-versus-anterior-circulation-stroke-in-young-adults-a-comparative-study-of-stroke-aetiologies-and-risk-factors-in-stroke-among-young-fabry-patients-sifap1
#2
Bettina von Sarnowski, Ulf Schminke, Ulrike Grittner, Christian Tanislav, Tobias Böttcher, Michael G Hennerici, Turgut Tatlisumak, Jukka Putaala, Manfred Kaps, Franz Fazekas, Christian Enzinger, Arndt Rolfs, Christof Kessler
BACKGROUND: Although 20-30% of all strokes occur in the posterior circulation, few studies have explored the characteristics of patients with strokes in the posterior compared to the anterior circulation so far. Especially data on young patients is missing. METHODS: In this secondary analysis of data of the prospective multi-centre European sifap1 study that investigated stroke and transient ischemic attack (TIA) patients aged 18-55 years, we compared vascular risk factors, stroke aetiology, presence of white matter hyperintensities (WMH) and cerebral microbleeds (CMB) between patients with ischaemic posterior circulation stroke (PCS) and those having suffered from anterior circulation stroke (ACS) based on cerebral MRI...
January 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28088797/automated-interpretation-of-pulmonary-function-tests-in-adults-with-respiratory-complaints
#3
Marko Topalovic, Stefan Laval, Jean-Marie Aerts, Thierry Troosters, Marc Decramer, Wim Janssens
BACKGROUND: The use of pulmonary function tests is primarily based on expert opinion and international guidelines. Current interpretation strategies are using predefined cutoffs for the description of a typical pattern. OBJECTIVES: We aimed to explore the predicted disease outcome based on the American Thoracic Society/European Respiratory Society (ATS/ERS) interpreting strategy. Subsequently, we investigated whether an unbiased machine learning framework integrating lung function with clinical variables may provide alternative decision trees resulting in a more accurate diagnosis...
January 12, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28088781/mir-30c-5p-ameliorates-hepatic-steatosis-in-leptin-receptor-deficient-db-db-mice-via-down-regulating-fasn
#4
Jiahui Fan, Huaping Li, Xiang Nie, Zhongwei Yin, Yanru Zhao, Chen Chen, Dao Wen Wang
Approximately 15-40% of the general adult population suffers from non-alcoholic fatty liver disease (NAFLD) worldwide. However, no drug is currently licensed for its treatment. In this study, we observed a significant reduction of miR-30c-5p in the liver of leptin receptor-deficient (db/db) mice. Remarkably, recombinant adeno-associated virus (rAAV)-mediated delivery of miR-30c-5p was sufficient to attenuate triglyceride accumulation and hepatic steatosis in db/db mice. Through computational prediction, KEGG analysis and Ago2 co-immunoprecipitation, we identified that miR-30c-5p directly targeted fatty acid synthase, a key enzyme in fatty acid biosynthesis...
January 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28088775/diagnostic-accuracy-of-glycated-hemoglobin-for-post-transplantation-diabetes-mellitus-after-kidney-transplantation-systematic-review-and-meta-analysis
#5
Ana Laura Pimentel, Gabriela Cavagnolli, Joíza Lins Camargo
BACKGROUND: Early detection of post-transplantation diabetes mellitus (PTDM) allows prompt clinical and pharmacological interventions, reducing the chance of adverse outcomes. We conducted a systematic review and meta-analysis to determine the overall diagnostic accuracy of glycated hemoglobin (HbA1c) for the diagnosis of renal PTDM. METHODS: We searched MEDLINE, Embase and SCOPUS up to June 2016. Studies that included adults without previous diabetes were selected if they reported an oral glucose tolerance test as a reference test, HbA1c levels measured by standardized methods and data necessary for drawing 2 × 2 tables...
January 14, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28088746/development-of-a-screening-questionnaire-for-dsm-5-intermittent-explosive-disorder-ied-sq
#6
Emil F Coccaro, Mitchell E Berman, Michael S McCloskey
OBJECTIVE: This study was designed to develop and test a screening approach to identify individuals with DSM-5 Intermittent Explosive Disorder (IED), a disorder of recurrent, problematic, impulsive aggression. METHODS: A screening approach to diagnose DSM-5 IED (IED-SQ) was developed by combining items related to life history of aggression and items related to the DSM-5 diagnostic criteria for IED. In study 1, the IED-SQ was studied in 72 adult participants; 33 that met DSM-5 criteria for lifetime IED and 39 that did not...
December 22, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28088742/patterns-of-drug-use-and-hiv-infection-among-adults-in-a-nationally-representative-sample
#7
Stephanie Shiau, Stephen M Arpadi, Michael T Yin, Silvia S Martins
BACKGROUND: Little is known about drug use patterns among people living with HIV in comparison to an uninfected group in the general population. The aim of this study was to investigate the association between legal and illegal drug use and HIV infection in a nationally representative sample of adults in the United States. METHODS: Public use data files (2005-2014) from the National Survey on Drug Use and Health (NSDUH) were used. Respondents were asked whether a medical professional had ever told them that they had HIV/AIDS...
January 7, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28088741/prevalence-and-correlates-of-fentanyl-contaminated-heroin-exposure-among-young-adults-who-use-prescription-opioids-non-medically
#8
Alexandria Macmadu, Jennifer J Carroll, Scott E Hadland, Traci C Green, Brandon D L Marshall
BACKGROUND: The rate of overdose deaths caused by fentanyl-contaminated heroin (FCH) use is increasing rapidly in the United States. We examined risk factors for exposure to FCH and experiences with FCH use among young adult non-medical prescription opioids (NMPO) users. METHODS: We analyzed data from the Rhode Island Young Adult Prescription Drug Study (RAPiDS), which enrolled young adults aged 18 to 29 reporting prior 30day NMPO use between January 2015 and February 2016...
January 6, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28088739/the-effects-of-rurality-on-substance-use-disorder-diagnosis-a-multiple-groups-latent-class-analysis
#9
Billy Brooks, Matthew McBee, Robert Pack, Arsham Alamian
BACKGROUND: Rates of accidental overdose mortality from substance use disorder (SUD) have risen dramatically in the United States since 1990. Between 1999 and 2004 alone rates increased 62% nationwide, with rural overdose mortality increasing at a rate 3 times that seen in urban populations. Cultural differences between rural and urban populations (e.g., educational attainment, unemployment rates, social characteristics, etc.) affect the nature of SUD, leading to disparate risk of overdose across these communities...
January 6, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28088727/representativeness-of-clinical-pet-study-participants-with-schizophrenia-a-systematic-review
#10
So Kirino, Takefumi Suzuki, Hiroyoshi Takeuchi, Masaru Mimura, Hiroyuki Uchida
While positron emission tomography (PET) studies have provided invaluable data on antipsychotic effects, selection bias remains a serious concern. A systematic review of PET studies that measured dopamine D2 receptor blockade with antipsychotics was conducted to examine their inclusion/exclusion criteria, using PubMed, EMBASE, and ClinicalTrials.gov (last search, September 2016). PET studies were included if they measured D2 receptor occupancy in patients with schizophrenia and included introduction of antipsychotic treatment or antipsychotic regimen change in a systematic manner...
January 5, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28088714/children-s-and-adults-use-of-verbal-information-to-visually-anticipate-others-actions-a-study-on-explicit-and-implicit-social-cognitive-processing
#11
Markus Paulus, Tobias Schuwerk, Beate Sodian, Kerstin Ganglmayer
According to recent theories, social cognition is based on two different types of information-processing; an implicit or action-based one and an explicit or verbal one. The present study examined whether implicit and explicit social-cognitive information processing interact with each other by investigating young children's and adults' use of verbal (i.e., explicit) information to predict others' actions. Employing eye-tracking to measure anticipatory eye-movements as a measure of implicit processing, Experiment 1 presented 1...
January 12, 2017: Cognition
https://www.readbyqxmd.com/read/28088713/the-effects-of-utterance-timing-and-stimulation-of-left-prefrontal-cortex-on-the-production-of-referential-expressions
#12
Jennifer E Arnold, Nazbanou Nozari
We examined the relationship between the timing of utterance initiation and the choice of referring expressions, e.g., pronouns (it), zeros (…and went down), or descriptive NPs (the pink pentagon). We examined language production in healthy adults, and used anodal transcranial direct current stimulation (tDCS) to test the involvement of the left prefrontal cortex (PFC) in the timing of utterance production and the selection of reference forms in a discourse context. Twenty-two subjects (11 anodal, 11sham) described fast-paced actions, e...
January 12, 2017: Cognition
https://www.readbyqxmd.com/read/28088704/an-examination-of-the-anxiolytic-effects-of-exercise-for-people-with-anxiety-and-stress-related-disorders-a-meta-analysis
#13
REVIEW
Brendon Stubbs, Davy Vancampfort, Simon Rosenbaum, Joseph Firth, Theodore Cosco, Nicola Veronese, Giovanni A Salum, Felipe B Schuch
The literature regarding exercise for people with established anxiety disorders is equivocal. To address this issue, we conducted a systematic review and meta-analysis investigating the benefits of exercise compared to usual treatment or control conditions in people with an anxiety and/or stress-related disorders. Major electronic databases were searched from inception until December/2015 and a random effect meta-analysis conducted. Altogether, six randomized control trials (RCTs) including 262 adults (exercise n=132, 34...
January 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28088654/transcriptional-response-of-skeletal-muscle-to-a-low-protein-perinatal-diet-in-rat-offspring-at-different-ages-the-role-of-key-enzymes-of-glucose-fatty-acid-oxidation
#14
José Luiz de Brito Alves, Ana Elisa Toscano, João Henrique da Costa-Silva, Hubert Vidal, Carol Góis Leandro, Luciano Pirola
Skeletal muscle is a plastic tissue during development with distinctive acute and chronic response to maternal protein restriction. This study evaluated gene and protein expression of key-enzymes of glycolytic pathway (HK2, PFK, PDK4 and CS), and fatty acid oxidation (CPT1 and β-HAD) of two different types of skeletal muscle [soleus and extensor digitorium longus (EDL)] from offspring rats at 30 and 90 days of age, exposed to maternal isoenergetic low protein diet throughout gestation and lactation. Pups from dams fed 17% protein diet (n=5, normal protein, Np), and low protein pups from dams fed 8% casein diet (low protein, Lp, n=5) were evaluated...
December 15, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28088650/assessing-the-identity-and-expression-level-of-the-cytochrome-p450-20a1-cyp20a1-gene-in-the-bpa-bde-47-and-waf-exposed-copepods-tigriopus-japonicus-and-paracyclopina-nana
#15
Jeonghoon Han, Duck-Hyun Kim, Jung Soo Seo, Il-Chan Kim, David R Nelson, Jayesh Puthumana, Jae-Seong Lee
CYP20A1 is a member of the cytochrome P450 (CYP) superfamily, identified as an orphan P450 without any assigned biological function; hence, its continued status as an "orphan" gene. In order to address this shortcoming in our understanding of this superfamily, we sought to characterize the CYP20A1 gene in the copepods Tigriopus japonicus (Tj-CYP20A1) and Paracyclopina nana (Pn-CYP20A1) at their mRNA transcriptional level. We assessed the response of this gene's expression in various developmental stages and in response to treatment with bisphenol A (BPA), 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47), and water accommodated fractions (WAFs) of crude oil...
January 11, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28088647/the-developmental-relationship-between-specific-cognitive-domains-and-grey-matter-in-the-cerebellum
#16
Dorothea M Moore, Anila M D'Mello, Lauren M McGrath, Catherine J Stoodley
There is growing evidence that the cerebellum is involved in cognition and cognitive development, yet little is known about the developmental relationship between cerebellar structure and cognitive subdomains in children. We used voxel-based morphometry to assess the relationship between cerebellar grey matter (GM) and language, reading, working memory, executive function, and processing speed in 110 individuals aged 8-17 years from the Pediatric Imaging, Neurocognition, and Genetics (PING) Study. Further, we examined the effect of age on the relationships between cerebellar GM and cognition...
December 21, 2016: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28088606/choice-of-factor-viii-ix-regimen-in-adolescents-and-young-adults-with-severe-or-moderately-severe-haemophilia-a-french-national-observational-study-orthem-15-25
#17
Sandrine Meunier, Roseline d'oiron, Hervé Chambost, Edita Dolimier, Benoît Guillet
INTRODUCTION: The value and challenges of long-term prophylaxis (LTP) in adolescents and young adults need further characterisation. AIM: To determine the proportions of adolescents and young adults with severe or moderately severe haemophilia in France under LTP and treatment on demand (OD). METHODS: Patients 15 to 25years old with haemophilia A or B, factor VIII/IX ≤2% and no current inhibitor could be included if they had been under factor VIII/IX treatment at least 12months and kept a treatment and bleeding diary...
December 28, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28088605/comparison-of-the-anterior-chamber-angle-structure-between-children-and-adults
#18
Yukiko Shimizu, Shunsuke Nakakura, Toshihiko Nagasawa, Akiko Okamoto, Hitoshi Tabuchi, Yoshiaki Kiuchi
PURPOSE: To investigate the anterior chamber structure in children and adults with a similar axial length (AL). METHODS: A total of 50 children (mean age, 7.1 ± 3.3 years; range, 3-16) with mainly refractive error and 50 adults (mean age, 73.7 ± 7.8 years; range, 50-85) with short AL were included. The mean AL was 22.21 ± 0.88 mm (range, 20.67-23.97 mm) in children; 22.34 ± 0.53 mm (range, 20.50-22.96 mm), in adults. The corneal curvature, spherical equivalent, AL, central corneal thickness (CCT), inter-scleral spur distance, perpendicular distance, anterior chamber depth (ACD), angle opening distance (AOD), and lens vault were measured...
January 11, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28088560/role-of-comorbidities-and-in-hospital-complications-in-short-term-status-epilepticus-outcome
#19
Marco Belluzzo, Giovanni Furlanis, Lara Stragapede, Fabrizio Monti
OBJECTIVE: pre-morbid patient conditions and hospitalization complications possibly play a role in status epilepticus short-term outcome, although evidence is incomplete and non-conclusive. The study's aim was to define whether comorbidities and in-hospital complications arising after status epilepticus affect its prognosis. METHODS: A retrospective single center study was carried out. All selected patients were adults presenting an EEG-proven status epilepticus episode between 2003 and 2014...
December 30, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28088474/diagnostic-accuracy-of-fractional-exhaled-nitric-oxide-in-predicting-cough-variant-asthma-and-eosinophilic-bronchitis-in-adult-patients-with-chronic-cough-a-systematic-review-and-meta-analysis
#20
Woo-Jung Song, Hyun Jung Kim, Ji-Su Shim, Ha-Kyeong Won, Sung-Yoon Kang, Kyoung-Hee Sohn, Byung-Keun Kim, Eun-Jung Jo, Min-Hye Kim, Sang-Heon Kim, Heung-Woo Park, Sun-Sin Kim, Yoon-Seok Chang, Alyn H Morice, Byung-Jae Lee, Sang-Heon Cho
BACKGROUND: Individual studies suggested the utility of fractional exhaled nitric oxide (FeNO) in detecting cough variant asthma (CVA) and eosinophilic bronchitis (EB) in chronic cough patients. OBJECTIVE: To obtain summary estimates of diagnostic test accuracy of FeNO in predicting CVA and/or EB in adult patients with chronic cough METHODS: Electronic databases were searched for studies published until January 2016, without language restriction. Cross-sectional studies which reported the diagnostic accuracy of FeNO for detecting CVA or EB were included...
January 11, 2017: Journal of Allergy and Clinical Immunology
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