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https://www.readbyqxmd.com/read/27936516/neuroprotection-of-hypoxic-postconditioning-against-global-cerebral-ischemia-through-influencing-posttranslational-regulations-of-heat-shock-protein-27-in-adult-rats
#1
Lixuan Zhan, Liu Liu, Kongping Li, Baoxing Wu, Dandan Liu, Donghai Liang, Haixia Wen, Yanmei Wang, Weiwen Sun, Weiping Liao, En Xu
We previously reported that hypoxic postconditioning (HPC) ameliorated hippocampal neuronal death induced by transient global cerebral ischemia (tGCI) in adult rats. However, the mechanism of HPC-induced neuroprotection is still elusive. Notably, heat shock protein 27 (Hsp27) has recently emerged as a potent neuroprotectant in cerebral ischemia. Although its robust protective effect on stroke has been recognized, the mechanism of Hsp27-mediated neuroprotection is largely unknown. Here, we investigated the potential molecular mechanism by which HPC modulates the posttranslational regulations of Hsp27 after tGCI...
December 9, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27936482/intrahepatic-cholestasis-of-pregnancy-icp-case-report-and-review-of-the-literature
#2
V Keitel, C Dröge, S Stepanow, T Fehm, E Mayatepek, K Köhrer, D Häussinger
Intrahepatic cholestasis of pregnancy (ICP) represents the most common pregnancy-related liver disease in women. Women frequently present in the third trimester with pruritus and elevated serum bile acid and/or alanine transaminase levels. Clinical symptoms quickly resolve after delivery; however, recurrence in subsequent pregnancies has to be expected. Intrahepatic cholestasis of pregnancy is associated with increased perinatal complications, such as premature delivery, meconium staining of the amniotic fluid, respiratory distress, low Apgar scores, and even stillbirth...
December 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27936471/prevalence-of-lens-opacities-in-adult-chinese-americans-the-chinese-american-eye-study-ches
#3
Rohit Varma, Jie Sun, Mina Torres, Shuang Wu, Chunyi Hsu, Stanley Paul Azen, Roberta McKean-Cowdin
Purpose: We determined the age- and sex-specific prevalence of posterior subcapsular (PSC), nuclear, cortical, and mixed lens opacities in a population-based sample of Chinese-American adults. Methods: A population-based sample of Chinese-Americans 50 years and older, from 10 census tracts in Monterey Park, CA, USA, underwent a detailed interview and a comprehensive clinical examination that included assessment of different types of lens opacities by the slit-lamp-based Lens Opacities Classification System II (LOCS II)...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27936458/predictors-of-functional-disability-with-focus-on-activities-of-daily-living-a-community-based-follow-up-study-in-older-adults-in-india
#4
Aarti Nagarkar, Yashoda Kashikar
BACKGROUND: Disability in activities of daily living is a growing concern among older populations all over the world. India has one of the rapidly ageing populations and predicted burden of functional disability is higher for Indian older adults as compared to other ageing Asian countries. METHODS: Total 1140 aged 60 years and over participated in a baseline study. 560 of them participated in the prospective cohort study conducted in the city of Pune, India. An interview and functional assessment using a questionnaire and Pune-FAAT tool was carried out in 2013-14...
December 2, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27936422/social-network-types-among-older-korean-adults-associations-with-subjective-health
#5
Sung Yun Sohn, Won-Tak Joo, Woo Jung Kim, Se Joo Kim, Yoosik Youm, Hyeon Chang Kim, Yeong-Ran Park, Eun Lee
With population aging now a global phenomenon, the health of older adults is becoming an increasingly important issue. Because the Korean population is aging at an unprecedented rate, preparing for public health problems associated with old age is particularly salient in this country. As the physical and mental health of older adults is related to their social relationships, investigating the social networks of older adults and their relationship to health status is important for establishing public health policies...
December 1, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27936410/body-image-and-emotional-distress-in-newly-diagnosed-cancer-patients-the-mediating-role-of-dysfunctional-attitudes-and-rumination
#6
Jianlin Liu, Chao Xu Peh, Rathi Mahendran
Body image concerns (BIC) has been reported to be associated with emotional distress for cancers across various sites. This study sought to examine two cognitive vulnerability mechanisms: dysfunctional attitudes and rumination, and their combined effects on the relationship between BIC and emotional distress in newly diagnosed Asian cancer patients. Participants were 221 newly diagnosed adult cancer patients who were assessed on BIC, rumination, dysfunctional attitudes, and emotional distress. Path analysis was used to examine the hypothesized mediation model...
December 6, 2016: Body Image
https://www.readbyqxmd.com/read/27936404/dexmedetomidine-vs-propofol-sedation-reduces-delirium-in-patients-after-cardiac-surgery-a-meta-analysis-with-trial-sequential-analysis-of-randomized-controlled-trials
#7
Xu Liu, Guohao Xie, Kai Zhang, Shengwen Song, Fang Song, Yue Jin, Xiangming Fang
PURPOSE: It is uncertain whether dexmedetomidine is better than propofol for sedation in postcardiac surgery patients. The purpose of this meta-analysis was to compare the effects of dexmedetomidine and propofol sedation on outcomes in adult patients after cardiac surgery. METHODS: Randomized controlled trials comparing outcomes in cardiac surgery patients sedated with dexmedetomidine or propofol were retrieved from PubMed, Embase, Web of Science, the Cochrane Library, and Clinicaltrials...
November 11, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27936389/ethanolic-extract-of-dalbergia-sissoo-promotes-rapid-regeneration-of-cortical-bone-in-drill-hole-defect-model-of-rat
#8
Vikram Khedgikar, Priyanka Kushwaha, Naseer Ahmad, Jyoti Gautam, Padam Kumar, Rakesh Maurya, Ritu Trivedi
Leaves of Dalbergia sissoo is known to have protective actions against postmenopausal bone loss in rat. In this study, we have evaluated the fracture healing properties of ethanolic extract (EE) of Dalbergia sissoo leaves. To observe the fracture healing property in the drill-hole injury model, we randomly divided total 32 adult female Sprague Dawley rats (180±200g) into 4 groups: (i) Control operated group; (ii) EE (250mg/kg/day); (iii) EE (500mg/kg/day) and (iv) EE (1000mg/kg/day). The right femora were fractured at the mid-diaphysis region and each group of rats received their respective treatment for 15days...
December 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27936375/putting-adolescents-at-risk-riding-with-drinking-drivers-who-are-adults-in-the-home
#9
Sion K Harris, Julie K Johnson, Lon Sherritt, Sarah Copelas, Melissa A Rappo, Celeste R Wilson
OBJECTIVE: Alcohol-related car crashes are a leading cause of adolescent death, and one in five U.S. adolescents reports recent riding in a car with a drinking driver. How often the driver is an adult in the home (e.g., parent) is unknown. Pediatric visits offer an opportunity to counsel families to reduce this risk. Our study aim was to determine the prevalence of recent riding with a drinking driver (RWDD) who was an adult in the home among adolescent primary care patients and to identify the demographic and environmental (substance use among family members) profiles of those at increased risk...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936374/testing-a-matching-hypothesis-for-emerging-adults-in-project-match-during-treatment-and-one-year-outcomes
#10
Jordan P Davis, Brandon G Bergman, Douglas C Smith, John F Kelly
OBJECTIVE: Compared with older adults, emerging adults (18-29 years old) entering treatment typically have less severe alcohol use consequences. Also, their unique clinical presentations (e.g., modest initial abstinence motivation) and developmental contexts (e.g., drinking-rich social networks) may make a straightforward implementation of treatments developed for adults less effective. Yet, this has seldom been examined empirically. This study was a secondary analysis of Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity) data examining (a) overall differences between emerging adults and older adults (≥30 years old) on outcomes during treatment and at 1-year follow-up, and (b) whether emerging adults had poorer outcomes on any of the three Project MATCH treatments in particular...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936367/alcohol-warning-label-perceptions-do-warning-sizes-and-plain-packaging-matter
#11
Mohammed Al-Hamdani, Steven M Smith
OBJECTIVE: There is a dearth of research on the effectiveness of stringent alcohol warning labels. Our experiment tested whether increasing the size of an alcohol health warning lowers product-based ratings. We examined whether plain packaging lowers ratings of alcohol products and the consumers who use them, increases ratings of bottle "boringness," and enhances warning recognition compared with branded packaging. METHOD: A total of 440 adults (51.7% female) viewed one of three warning sizes (50%, 75%, or 90% of label surface) on either a plain or branded bottle of distilled spirits, wine, and beer...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936348/current-prospects-and-future-challenges-for-nasal-vaccine-delivery
#12
Helmy Yusuf, Vicky Kett
Nasal delivery offers many benefits over traditional approaches to vaccine administration. These include ease of administration without needles that reduces issues associated with needlestick injuries and disposal. Additionally, this route offers easy access to a key part of the immune system that can stimulate other mucosal sites throughout the body. Increased acceptance of nasal vaccine products in both adults and children has led to a burgeoning pipeline of nasal delivery technology. Key challenges and opportunities for the future will include translating in vivo data to clinical outcomes...
December 9, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27936344/safety-and-immunogenicity-of-a-herpes-zoster-subunit-vaccine-in-japanese-population-aged-%C3%A2-50%C3%A2-years-when-administered-subcutaneously-versus-intramuscularly
#13
Peter Vink, Masanari Shiramoto, Masayuki Ogawa, Masahiro Eda, Martine Douha, Thomas Heineman, Himal Lal
The impact of alternate routes of vaccine administration, subcutaneous (SC) or intramuscular (IM), on the safety and immunogenicity of herpes zoster subunit candidate vaccine (HZ/su) was assessed in Japanese adults aged ≥ 50 years. During this phase III open-label study, 60 subjects were randomized (1:1) to receive HZ/su through SC or IM routes in a 0, 2 month schedule. Vaccine response rates (VRRs) and geometric mean concentrations (GMCs) of varicella zoster virus glycoprotein E (gE)-specific antibodies were determined by ELISA...
December 9, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27936337/alcohol-use-in-an-older-adult-referred-to-a-consultation-liaison-psychiatry-service-a-case-report
#14
Adam Searby, Natalie van Swet, Phil Maude, Ian McGrath
Alcohol use disorder in older adults is associated with a number of substantial medical complications, including cognitive decline. Due to limited success and application of screening approaches in this cohort, older adults are more likely to present to general hospital settings with undiagnosed problematic alcohol use. Consultation-liaison psychiatry services operating in general hospital settings are likely to be referred older adults with alcohol use disorders for assessment and management. A 77-year-old female presented to a metropolitan hospital with symptoms including frequent falls, slurred speech, difficulty judging distance, hypersomnia, poor reasoning, and odd behaviours...
December 9, 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27936334/overview-of-substance-use-and-mental-health-among-the-baby-boomers-generation
#15
Michelle Cleary, Jan Sayers, Marguerite Bramble, Debra Jackson, Violeta Lopez
As the population ages, risk factors commonly shared by chronic degenerative disease can be exacerbated by behaviours and lifestyle choices. There is increasing evidence that those affected by chronic disease (and associated symptoms such as pain), depression and adverse behavioural and lifestyle patterns are at risk of substance misuse. This paper overviews substance use in Baby Boomers, which are defined as people aged between 52-70 years old, and the implications this may have on their mental health and well-being...
December 9, 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27936333/alcohol-use-disorder-in-older-adults-challenges-in-assessment-and-treatment
#16
Mary C DiBartolo, Judith M Jarosinski
Alcohol use disorder (AUD) is a common, under-recognized, and under-treated health concern in older adults. Its prevalence is expected to reach unprecedented levels as the U.S. population ages; consequently, it is poised to place a significant burden on the healthcare system. Given the growing body of evidence regarding the patterns of use in this age group and the serious consequences of its misuse, it is critical that nurses and other healthcare providers assess for AUD in order to identify older adults in need of treatment...
December 9, 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27936332/an-association-of-serum-alt-with-elevated-blood-pressure-in-senior-adults-a-case-control-study
#17
Xiuqin Hong, Nualnong Wongtongkam, Paul Russell Ward, Shuiyuan Xiao, Shuling Wang, Qian Peng, Qi Zuo, Dan Zeng, Jia Wang, Chenxu Wang, Jian Chen, Na Zhang
Hypertension is a major risk factor for cardiovascular diseases in China; hence, identifying good serum markers might provide cost benefits in terms of reducing morbidity rates. In this population-based case-control study, participants were recruited from five districts in Hunan province, and 416 cases were matched with an equal number of controls. Markers related to elevated blood pressure were assessed: Body Mass Index, total cholesterol, triglycerides, fasting blood glucose, and creatinine. Three potential serum markers homocysteine (HCY), C-reactive protein (CRP), and alanine aminotransferase (ALT) were dichotomized as normal or high level...
December 9, 2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27936331/parenting-emerging-adults-who-game-excessively-parents-lived-experiences
#18
Linda L H Russell, Elizabeth I Johnson
Excessive gaming among emerging adults is a growing concern, especially in cases where it interferes with key developmental milestones such as gaining an education or establishing a career. Although researchers have begun to understand the effects of excessive gaming on young people themselves, we know remarkably little about how emerging adults' gaming may affect family relationships. Utilizing phenomenological interviewing of parents of emerging adult sons who game excessively, this study presents a rich description of the experience of parenting a young adult who games excessively...
December 9, 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27936310/schistosomicidal-effects-of-the-essential-oils-of-citrus-limonia-and-c-reticulata-against-schistosoma-mansoni
#19
Moara H G Martins, Letícia Fracarolli, Tatiana M Vieira, Herbert J Dias, Michele G Cruz, Cássia C H Deus, Heloiza D Nicolella, Ricardo Stefani, Vanderlei Rodrigues, Denise C Tavares, Lizandra G Magalhães, Antônio E M Crotti
We report the in vitro schistosomicidal effects of the essential oil obtained from Citrus limonia leaves (CL-EO) and C. reticulata fruit peels (CR-EO), cultivated in Brazil, against Schistosoma mansoni worms. Limonene (29.9%), β-pinene (12.0%), sabinene (9.0%), citronellal (9.0%), and citronellol (5.8%) are the major constituents of CL-EO; limonene (26.5%), γ-terpinene (17.2%), linalool (11.1%), octanal (8.0%), myrcene (6.2%), and capraldehyde (3.9%) predominate in CR-EO. CL-EO displayed moderate lethal concentration 50% (LC50 ) of 81...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27936293/effects-of-incentives-for-naltrexone-adherence-on-opiate-abstinence-in-heroin-dependent-adults
#20
Brantley P Jarvis, August F Holtyn, Anthony DeFulio, Kelly E Dunn, Jeffrey J Everly, Jeannie-Marie S Leoutsakos, Annie Umbricht, Michael Fingerhood, George E Bigelow, Kenneth Silverman
AIM: To test whether an incentive-based intervention that increased adherence to naltrexone also increased opiate abstinence. DESIGN: Post-hoc combined analysis of three earlier randomized controlled trials that individually showed that incentives for adherence to oral and to extended-release injection naltrexone dosing schedules increased naltrexone adherence but not opiate abstinence. SETTING: Outpatient therapeutic workplace in Baltimore, MD, USA...
December 9, 2016: Addiction
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