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https://www.readbyqxmd.com/read/29036997/-mean-blood-pressure-among-the-adults-in-china-2010-2012-based-on-the-results-of-mercury-sphygmomanometer-and-converted-electronic-sphygmomanometer
#1
D M Yu, P Fu, W T Yu, H J Guo, X G Yang, W H Zhao, L Y Zhao
Objective: To analyze the average systolic blood pressure (SBP) and diastolic blood pressure (DBP) among adults aged 18 years old and above in China between 2010 and 2012; and to compare the difference in the results measured by mercury sphygmomanometer and converted electronic sphygmomanometer. Methods: The data was collected from Chinese Nutrition and Health Surveillance in 2010-2012. 120 428 adults aged 18 years old and above were selected from 150 survey counties (districts) of 31 provinces in China Mainland, by multi-stage stratified and probability proportion to size (PPS) cluster randomization sampling method...
October 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29036971/-chinese-expert-consensus-statement-on-clinical-diagnosis-and-treatment-of-fulminant-myocarditis-in-adults
#2
(no author information available yet)
No abstract text is available yet for this article.
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036955/-comparision-of-risk-factors-and-pathogens-in-patients-with-early-and-late-onset-ventilator-associated-pneumonia-in-intensive-care-unit
#3
Y J Liang, Z L Li, L Wang, B Y Liu, R Y Ding, X C Ma
Objective: To compare risk factors and bacterial etiology in patients with early-onset versus late-onset ventilator-associated pneumonia (VAP) in intensive care unit (ICU). Methods: This prospective cohort study enrolled mechanically ventilated patients hospitalized for more than 48 hours in the first affiliated hospital, China Medical University from Jan 2012 to Jun 2016. Subjects were classified by ventilator status: early-onset VAP (< 5 d ventilation, E-VAP) or late-onset VAP (≥ 5 d ventilation, L-VAP)...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036937/behaviors-related-to-mosquito-borne-diseases-among-different-ethnic-minority-groups-along-the-china-laos-border-areas
#4
Chao Wu, Xiaofang Guo, Jun Zhao, Quan Lv, Hongbin Li, Edward B McNeil, Virasakdi Chongsuvivatwong, Hongning Zhou
Background: In China, mosquito-borne diseases are most common in the sub-tropical area of Yunnan province. The objective of this study was to examine behaviors related to mosquito-borne diseases in different ethnic minority groups and different socioeconomic groups of people living in this region. Methods: A stratified two-stage cluster sampling technique with probability proportional to size was used in Mengla County, Xishuangbanna Prefecture, Yunnan. Twelve villages were used to recruit adult (≥18 years old) and eight schools were used for children (<18 years old)...
October 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29036936/barriers-and-facilitators-for-health-behavior-change-among-adults-from-multi-problem-households-a-qualitative-study
#5
Gera E Nagelhout, Lette Hogeling, Renate Spruijt, Nathalie Postma, Hein de Vries
Multi-problem households are households with problems on more than one of the following core problem areas: socio-economic problems, psycho-social problems, and problems related to child care. The aim of this study was to examine barriers and facilitators for health behavior change among adults from multi-problem households, as well as to identify ideas for a health promotion program. A qualitative study involving 25 semi-structured interviews was conducted among Dutch adults who received intensive family home care for multi-problem households...
October 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29036913/alpha-galacto-oligosaccharides-at-low-dose-improve-liver-steatosis-in-a-high-fat-diet-mouse-model
#6
Eric Chappuis, Fanny Morel-Depeisse, Bruno Bariohay, Julien Roux
Non-Alcoholic Fatty Liver Disease (NAFLD) is the major liver disease worldwide and is linked to the development of metabolic syndrome and obesity. As alpha-galacto-oligosaccharides (α-GOS) from legumes have been shown to reduce body weight and hyperphagia in overweight adults, it was hypothesized that they would exert benefits on the development of metabolic syndrome and associated NAFLD in a rodent model. C57Bl/6J mice were fed a high-fat diet until they developed metabolic syndrome and were then orally treated either with α-GOS at a physiological dose (2...
October 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29036912/caustic-ingestion-in-the-elderly-influence-of-age-on-clinical-outcome
#7
Blazena Caganova, Tatiana Foltanova, Erik Puchon, Elena Ondriasova, Silvia Plackova, Tomas Fazekas, Magdalena Kuzelova
Caustic poisonings are still associated with many fatalities. Studies focusing on the elderly are rare. The purpose of the present study was to compare the clinical outcomes of caustic ingestion injury in elderly and non-elderly adults with regard to gender, intent of exposure, substance ingested, severity of mucosal injury, complications, and mortality. Caustic substance exposures reported to the National Toxicological Information Centre in Slovakia during 1998-2015 were reviewed retrospectively. The patients were divided into two groups: the non-elderly (<60 years) and elderly adults (≥60 years)...
October 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29036904/biopsychosocial-measures-related-to-chronic-low-back-pain-postural-control-in-older-adults
#8
Ryan Hulla, Robert J Gatchel, Angela Liegey-Dougall
This study examined the biopsychosocial measures related to postural control in the growing population of older adults (i.e., 60 years and older). The sample of the study consisted of 129 older adults (M = 74.45, SD = 6.95), with 34 males and 95 females; 36 were classified with chronic low-back pain (CLBP), and 93 without chronic low-back pain (NCLBP). Physical and psychosocial constructs were analyzed as predictors for postural control measures. Additionally, gender and classification of low-back pain were examined as moderators for all physical and psychosocial measures...
October 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29036854/functional-repertoire-of-interleukin-6-in-the-central-nervous-system-a-review
#9
Klaus Heese
In an aging society with dementia imposing an increasing threat to higher brain cognitive functions, understanding the molecular and cellular events of adult neurogenesis is imperative. Interleukin-6 (IL-6), along with its agonistic acting soluble receptor sIL-6R (the combined proteins are also known as Hyper-IL-6), is a promising cytokine that can support neurogenesis under conditions of neurodegeneration when neuron replacement is needed. In contrast to the previously reported gliogenic effects of activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis, this review summarizes recent studies showing that IL-6 activation can be neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29036832/neuropathological-comparison-of-adult-onset-and-juvenile-huntington-s-disease-with-cerebellar-atrophy-a-report-of%C3%A2-a%C3%A2-father-and-son
#10
Caitlin S Latimer, Margaret E Flanagan, Patrick J Cimino, Suman Jayadev, Marie Davis, Zachary S Hoffer, Thomas J Montine, Luis F Gonzalez-Cuyar, Thomas D Bird, C Dirk Keene
BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a trinucleotide (CAG) repeat expansion in huntingtin (HTT) on chromosome 4. Anticipation can cause longer repeat expansions in children of HD patients. Juvenile Huntington's disease (JHD), defined as HD arising before age 20, accounts for 5-10% of HD cases, with cases arising in the first decade accounting for approximately 1%. Clinically, JHD differs from the predominately choreiform adult onset Huntington's disease (AOHD) with variable presentations, including symptoms such as myoclonus, seizures, Parkinsonism, and cognitive decline...
October 11, 2017: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/29036824/alzheimer-s-disease-biomarkers-and-future-decline-in-cognitive-normal-older-adults
#11
Julien Dumurgier, Bernard J Hanseeuw, Frances B Hatling, Kelly A Judge, Aaron P Schultz, Jasmeer P Chhatwal, Deborah Blacker, Reisa A Sperling, Keith A Johnson, Bradley T Hyman, Teresa Gómez-Isla
BACKGROUND: Identifying older adults at risk of cognitive decline represents a challenge as Alzheimer's disease (AD) modifying therapies move toward preclinical stages. OBJECTIVE: To investigate the relationship between AD biomarkers and subsequent change in cognition in a cohort of cognitively intact older adults. METHODS: 84 cognitively normal subjects (mean age 72.0 years, 59% women) were recruited through the Massachusetts Alzheimer's Disease Research Center and the Harvard Aging Brain Study and followed over 3 years...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036816/sex-difference-in-aerobic-exercise-efficacy-to-improve-cognition-in-older-adults-with-vascular-cognitive-impairment-secondary-analysis-of-a-randomized-controlled-trial
#12
Cindy K Barha, Ging-Yuek R Hsiung, John R Best, Jennifer C Davis, Janice J Eng, Claudia Jacova, Philip E Lee, Michelle Munkacsy, Winnie Cheung, Teresa Liu-Ambrose
Aerobic training (AT) is a promising, non-pharmacological intervention to mitigate the deleterious effects of aging and disease on brain health. However, a large amount of variation exists in its efficacy. This is a secondary analysis of a randomized controlled trial of AT in 71 older adults with subcortical ischemic vascular cognitive impairment (NCT01027858). Specifically, we investigated: 1) whether sex moderates the relationship between AT and executive functions, and 2) the role of brain derived neurotrophic factor (BDNF) and gains in functional fitness capacity...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036758/comparison-of-single-task-versus-dual-task-for-listening-effort
#13
Chanbeom Kwak, Woojae Han
Background and Objectives: Depending on the kind of task and/or material, listeners sometimes need to pay attention to understand communication. The present study aimed to estimate a listener's amount of effort needed to understand communication by using recognition score and response time as a function of signal-to-noise ratio (SNR) and to confirm his/ her task dependency for listening effort. Subjects and Methods: Forty-eight young adults with normal hearing participated in the study...
October 17, 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29036727/economic-labor-and-regulatory-moderators-of-the-effect-of-individual-placement-and-support-among-people-with-severe-mental-illness-a-systematic-review-and-meta-analysis
#14
Justin D Metcalfe, Robert E Drake, Gary R Bond
As Individual Placement and Support (IPS) has become the international standard for vocational rehabilitation of adults with serious mental illness, researchers must consider the relationship between IPS and local environments. This meta-analysis used mixed-effects meta-regressions to assess the impact of site-level moderators on the likelihood that IPS recipients, compared with recipients of alternative vocational services, achieved competitive employment. Potential moderators included change in gross domestic product (GDP), local unemployment and unionization rates, and indices describing employment protection regulations, level of disability benefits compensation, and efforts to integrate people with disabilities into the workforce...
September 28, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036723/converting-from-transdermal-to-buccal-formulations-of-buprenorphine-a-pharmacokinetic-meta-model-simulation-in-healthy-volunteers
#15
Tony Priestley, Arvind K Chappa, Diane R Mould, Richard N Upton, Neil Shusterman, Steven Passik, Vicente J Tormo, Stephen Camper
OBJECTIVE:  To develop a model to predict buprenorphine plasma concentrations during transition from transdermal to buccal administration. DESIGN:  Population pharmacokinetic model-based meta-analysis of published data. METHODS:  A model-based meta-analysis of available buprenorphine pharmacokinetic data in healthy adults, extracted as aggregate (mean) data from published literature, was performed to explore potential conversion from transdermal to buccal buprenorphine...
September 29, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036705/chalcogenozidovudine-derivatives-with-antitumor-activity-comparative-toxicities-in-cultured-human-mononuclear-cells
#16
Assis Ecker, Pauline Christ Ledur, Rafael S da Silva, Daniela Bitencourt Rosa Leal, Oscar E D Rodrigues, Daniel Ardisson-Araújo, Emily Pansera Waczuk, João Batista Teixeira da Rocha, Nilda Vargas Barbosa
Considering a novel series of zidovudine (AZT) derivatives encompassing selenoaryl moieties promising candidates as therapeutics, we examined the toxicities elicited by AZT and derivatives 5'-(4-Chlorophenylseleno)zidovudine (SZ1); 5'-(Phenylseleno)zidovudine (SZ2); and 5'-(4-Methylphenylseleno)zidovudine (SZ3) in healthy cells and in mice. Resting and stimulated cultured human peripheral blood mononuclear cells (PBMCs) were treated with the compounds at concentrations ranging from 10 to 200 µM for 24 and/or 72 h...
July 28, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29036615/monitoring-of-cerebral-oximetry-during-head-up-tilt-test-in-adults-with-history-of-syncope-and-orthostatic-intolerance
#17
E Bachus, H Holm, V Hamrefors, O Melander, R Sutton, M Magnusson, A Fedorowski
Aims: We applied near-infrared-spectroscopy (NIRS) to measure absolute frontal cerebral tissue oxygen saturation (SctO2) during head-up tilt test (HUT) in patients investigated for unexplained syncope. Methods and results: Synchronized non-invasive beat-to-beat haemodynamic monitoring, ECG, SctO2 (NIRS; normal range: 60-80%), and peripheral oxygen saturation (left hand, SpO2) were applied during HUT in a random sample of patients with unexplained syncope. Tracings of 54 patients (mean-age: 55 ± 19 years, 39% male) with negative HUT, vasovagal syncope (VVS), or orthostatic hypotension (OH) were analysed...
September 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036565/long-term-risk-of-acute-myocardial-infarction-stroke-and-death-with-outpatient-use-of-clarithromycin-a-retrospective-cohort-study
#18
Andrew D Mosholder, Joo-Yeon Lee, Esther H Zhou, Elizabeth M Kang, Mayurika Ghosh, Rima Izem, Jacqueline M Major, David J Graham
This retrospective cohort study of subjects enrolled in the United Kingdom Clinical Practice Research Datalink from 2000-2013 evaluated long-term risks of death, stroke, and acute myocardial infarction (AMI) in adults prescribed clarithromycin. Subjects were outpatients aged 40-85 years prescribed clarithromycin, doxycycline, or erythromycin (287,748, 267,729, and 442,999 patients, respectively), or H. pylori eradication therapy with a proton pump inhibitor, amoxicillin, and either clarithromycin (27,639 patients) or metronidazole (14,863 patients)...
September 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29036559/the-brisk-standing-test-for-long-qt-syndrome-in-prepubertal-school-children-defining-normal
#19
L H P M Filippini, P G Postema, K Zoubin, B J M Hermans, N A Blom, T Delhaas, A A M Wilde
Aims: Long QT syndrome (LQTS) is associated with malignant arrhythmias and sudden death from birth to advanced age. Prolongation of the QT-interval, may however be concealed on standard electrocardiograms (ECG). The brisk-standing-test (BST) was developed to guide LQTS-diagnosis and treatment in adults. We hypothesized that the BST may be used in prepubertal children to identify LQTS subjects. Accordingly, reference values for the BST should be available to prevent incorrect diagnosis and treatment of LQTS...
October 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036554/contrast-venography-vs-microwire-assisted-axillary-venipuncture-for-cardiovascular-implantable-electronic-device-implantation
#20
Jahangir Rashid Beig, Bilal A Ganai, Mohammad S Alai, Ajaz A Lone, Imran Hafeez, Mohd Iqbal Dar, Nisar A Tramboo, Hilal A Rather
Aims: This study was conducted to compare the safety and efficacy of microwire assisted technique with contrast venography guided axillary venipuncture in patients undergoing cardiovascular implantable electronic device (CIED) implantation. Methods and results: This prospective randomized study included 212 consecutive adult patients undergoing CIED implantation at our institute between 2013 and 2015. Patients were randomized to either venography guided technique (Group I; n = 105) or microwire assisted technique (Group II; n = 107) for axillary venipuncture...
September 23, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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