Man Xing, Gaowei Hu, Xiang Wang, Yihan Wang, Furong He, Weiqian Dai, Xinyu Wang, Yixin Niu, Jiaojiao Liu, Hui Liu, Xiaoyan Zhang, Jianqing Xu, Qiliang Cai, Dongming Zhou
Despite prolonged surveillance and interventions, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses continue to pose a severe global health burden. Thus, we developed a chimpanzee adenovirus-based combination vaccine, AdC68-HATRBD, with dual specificity against SARS-CoV-2 and influenza virus. When used as a standalone vaccine, intranasal immunization with AdC68-HATRBD induced comprehensive and potent immune responses consisting of immunoglobin (Ig) G, mucosal IgA, neutralizing antibodies, and memory T cells, which protected the mice from BA...
March 21, 2024: NPJ Vaccines