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https://www.readbyqxmd.com/read/28633849/effects-of-bovine-serum-albumin-on-a-single-cavitation-bubble
#1
Shuibao Qi, Badreddine Assouar, Weizhong Chen
The dynamics and sonoluminescence (SL) of a single cavitation bubble in bovine serum albumin (BSA) aqueous solutions have been experimentally and theoretically investigated. A phase-locked integral imaging has been used to record the bubble pulsation evolutions. The results show that, under the optimum driving condition, the endurable driving pressure, maximum radius, radius compression ratio and SL intensity of the cavitation bubble increase correspondingly with the increase of BSA concentrations within the critical micelle concentration, which indicates that the addition of BSA increases the power capability of the cavitation bubble...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28623638/urokinase-containing-locking-solution-in-the-prevention-of-dialysis-catheter-dysfunction-a-double-blind-randomized-controlled-trial
#2
Florence Bonkain, Freya Van Hulle, Peter Janssens, Concetta Catalano, Mandelina Allamani, Jean-Claude Stolear, Dominique Vandervelde, Mark Libertalis, Serge Treille, Marie M Couttenye, Annemie Dhondt, Wim Van Biesen, Jean François Fils, Christian Tielemans, Karl M Wissing
INTRODUCTION: The prophylactic use of recombinant tissue plasminogen activator once weekly reduces the incidence rate of tunneled cuffed catheter (TCC) malfunction and bacteremia as compared to the exclusive use of heparin as locking solution. Restricting the use of prophylactic thrombolytic agents to patients with a history of thrombotic TCC malfunction could be more cost effective. We conduct a multicenter, double-blind, randomized controlled trial and test the hypothesis that weekly use of urokinase lock will reduce the incidence of thrombotic malfunction by 50% in prevalent hemodialysis patients with a history of thrombotic malfunction...
June 14, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28618492/spontaneous-exchange-of-leader-laggard-relationship-in-mutually-coupled-synchronized-semiconductor-lasers
#3
Kazutaka Kanno, Takuya Hida, Atsushi Uchida, Masatoshi Bunsen
We investigate the instantaneous behavior of synchronized temporal wave forms in two mutually coupled semiconductor lasers numerically and experimentally. The temporal wave forms of two lasers are synchronized with a propagation delay time, with one laser oscillating in advance of the other, known as the leader-laggard relationship. The leader-laggard relationship can be determined by measuring the cross-correlation between the two temporal wave forms with the propagation delay time. The leader can be identified when the optical carrier frequency of the leader laser is higher than that of the other laser...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28607194/solute-hydrogen-and-hydride-phase-implications-on-the-plasticity-of-zirconium-and-titanium-alloys-a-review-and-some-recent-advances
#4
REVIEW
E Conforto, I Guillot, X Feaugas
In this contribution, we propose a review of the possible implications of hydrogen on mechanical behaviour of Zr and Ti alloys with emphasis on the mechanisms of plasticity and strain hardening. Recent advances on the impact of oxygen and hydrogen on the activation volume show that oxygen content hinders creep but hydrogen partially screens this effect. Both aspects are discussed in terms of a locking-unlocking model of the screw dislocation mobility in prismatic slip. Additionally, possible extension of this behaviour is suggested for the [Formula: see text] pyramidal slip...
July 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28581726/ultrahigh-resolution-nmr-spectroscopy-for-rapid-chemical-and-biological-applications-in-inhomogeneous-magnetic-fields
#5
Yuqing Huang, Shuo-Hui Cao, Yu Yang, Shuhui Cai, Haolin Zhan, Chunhua Tan, Liangjie Lin, Zhiyong Zhang, Zhong Chen
NMR spectroscopy is a commonly used analytical technique in practical applications, and its applicability is further promoted by pure chemical shift techniques based on spectral simplification for analyses. Unfortunately, magnetic field inhomogeneity caused by adverse experimental conditions remains an obstacle restricting NMR applications. In this study, we introduce a new NMR method for high-resolution pure shift proton (1H) NMR measurements in inhomogeneous magnetic fields. We demonstrate that the method allows one to perform chemical analyses on complex solutions in deshimmed magnetic fields, to obtain metabolite information on intact biological tissues with intrinsic field inhomogeneities, and to achieve in situ electrochemical detection under externally adverse field conditions...
June 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28569374/quantitative-pulsed-cest-mri-at-a-clinical-3t-mri-system
#6
Julia Stabinska, Tom Cronenberg, Hans-Jörg Wittsack, Rotem Shlomo Lanzman, Anja Müller-Lutz
OBJECTIVES: The goal of this study was to quantify CEST related parameters such as chemical exchange rate and fractional concentration of exchanging protons at a clinical 3T scanner. For this purpose, two CEST quantification approaches-the AREX metric (for 'apparent exchange dependent relaxation'), and the AREX-based Ω-plot method were used. In addition, two different pulsed RF irradiation schemes, using Gaussian-shaped and spin-lock pulses, were compared. MATERIALS AND METHODS: Numerical simulations as well as MRI measurements in phantoms were performed...
May 31, 2017: Magma
https://www.readbyqxmd.com/read/28552113/preliminary-study-on-investigation-of-zoonotic-visceral-leishmaniasis-in-endemic-foci-of-ethiopia-by-detecting-leishmania-infections-in-rodents
#7
Wossenseged Lemma, Asrat Bizuneh, Habte Tekie, Habtamu Belay, Hirut Wondimu, Aysheshm Kassahun, Welelta Shiferaw, Meshesha Balkew, Ibrahim Abassi, Gad Baneth, Asrat Hailu
OBJECTIVE: To investigate the zoonotic visceral leishmaniasis (ZVL) by identification of the most probable reservoir hosts using parasite isolation and analysis of a possible transmission dynamics of the disease in extra-domestic agricultural fields and rural villages. METHODS: Rodents were collected from selected study sites in kala-azar endemic areas based on information for localities of kala-azar cases for screening of Leishmania infections using parasitological, serological and polymerase chain reaction (PCR) from March, 2013 to January, 2014...
April 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28532683/the-essential-oil-from-the-twigs-of-cinnamomum-cassia-presl-inhibits-oxytocin-induced-uterine-contraction-in-vitro-and-in-vivo
#8
Lan Sun, Li-Na Liu, Jia-Chun Li, Yao-Zhong Lv, Shao-Bo Zong, Jun Zhou, Zheng-Zhong Wang, Jun-Ping Kou, Wei Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: The twigs and bark of Cinnamomum cassia Presl (Lauraceae) are widely used in traditional Chinese medicine in the treatment of tumor, abdominal pain, dysmenorrhea, digestive system disease and inflammatory diseases. The aim of this study was to determine the inhibitory effect of the essential oil from the twigs of Cinnamomum cassia Presl (EOCC) on uterine contraction in vitro and in vivo. MATERIALS AND METHODS: The Institute of Cancer Research (ICR) mouse uterine contraction was induced by oxytocin (OT) exposure following estradiol benzoate pretreatment...
May 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28522836/dynamics-of-oscillators-globally-coupled-via-two-mean-fields
#9
Xiyun Zhang, Arkady Pikovsky, Zonghua Liu
Many studies of synchronization properties of coupled oscillators, based on the classical Kuramoto approach, focus on ensembles coupled via a mean field. Here we introduce a setup of Kuramoto-type phase oscillators coupled via two mean fields. We derive stability properties of the incoherent state and find traveling wave solutions with different locking patterns; stability properties of these waves are found numerically. Mostly nontrivial states appear when the two fields compete, i.e. one tends to synchronize oscillators while the other one desynchronizes them...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494155/principles-for-tuning-hydrophobic-ligand-receptor-binding-kinetics
#10
R Gregor Weiß, Piotr Setny, Joachim Dzubiella
We investigate how to tune the rate of hydrophobic ligand-receptor association due to the role of solvent in adjustable receptor pockets by explicit-water molecular dynamics (MD) simulations. Our model considers the binding of a spherical ligand (key/guest) to a concave surface recess in a nonpolar wall as receptor (lock/host). We systematically modify the receptor's physicochemical properties in terms of geometry and dispersion attraction which, in turn, alter the water occupancy and fluctuations within the pocket...
May 31, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28490835/from-non-preemptive-to-preemptive-scheduling-using-synchronization-synthesis
#11
Pavol Černý, Edmund M Clarke, Thomas A Henzinger, Arjun Radhakrishna, Leonid Ryzhyk, Roopsha Samanta, Thorsten Tarrach
We present a computer-aided programming approach to concurrency. The approach allows programmers to program assuming a friendly, non-preemptive scheduler, and our synthesis procedure inserts synchronization to ensure that the final program works even with a preemptive scheduler. The correctness specification is implicit, inferred from the non-preemptive behavior. Let us consider sequences of calls that the program makes to an external interface. The specification requires that any such sequence produced under a preemptive scheduler should be included in the set of sequences produced under a non-preemptive scheduler...
2017: Formal Methods in System Design
https://www.readbyqxmd.com/read/28484068/delivery-of-health-coaching-by-medical-assistants-in-primary-care
#12
Zora Djuric, Michelle Segar, Carissa Orizondo, Jeffrey Mann, Maya Faison, Nithin Peddireddy, Matthew Paletta, Amy Locke
BACKGROUND: Health coaching is potentially a practical method to assist patients in achieving and maintaining healthy lifestyles. In health coaching, the coach partners with the patient, helping patients discover their own strengths, challenges, and solutions. METHODS: Two medical assistants were provided with brief training. The 12-week program consisted of telephone coaching with in-person visits at the beginning and end of the program. Coaching targeted improvements in diet, physical activity, and/or sleep habits using a self-care planning form...
May 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28481531/chemically-induced-breathing-of-flexible-porphyrinic-covalent-cages
#13
Laetitia Schoepff, Lucas Kocher, Stéphanie Durot, Valérie Heitz
The synthesis of two flexible bis-porphyrin cages 3 and 4, incorporating respectively Zn(II) porphyrins and free-base porphyrins, is reported. In both cages, the four covalent linkers that bind the two porphyrins are functionalized with two 1,2,3-triazolyl ligands. These cages were characterized by NMR and HRMS, and for cage 3 incorporating 1,4-diazabicyclo[2.2.2]octane (DABCO), an X-ray crystallographic structure was obtained. Chemically induced conformational changes are studied and compared to those of two related cages with longer flexible linkers...
May 23, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28470316/top-down-fabrication-meets-bottom-up-synthesis-for-nanoelectronic-barcoding-of-microparticles
#14
Pengfei Xie, Xinnan Cao, Zhongtian Lin, Mehdi Javanmard
Traditional optical and plasmonic techniques for barcoding of micro-particles for multiplexed bioassays are generally high in throughput, however bulky instrumentation is often required for performing readout. Electrical impedance based detection allows for ultra-compact instrumentation footprint necessary for wearable devices, however to date, the lack of ability to electronically barcode micro-particles has been a long standing bottleneck towards enabling multiplexed electronic biomarker assays. Nanoelectronic barcoding, which to the best of our knowledge is the first impedance based solution for micro-particle barcoding, works by forming tunable nano-capacitors on the surface of micro-spheres, effectively modulating the frequency dependent dielectric properties of the spheres allowing one bead barcode to be distinguished from another...
May 31, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28463827/taurolidine-citrate-lock-therapy-for-primary-prevention-of-catheter-related-infections-in-cancer-patients-results-of-a-prospective-randomized-phase-iv-trial-atapac
#15
Raffaele Longo, Mathieu Llorens, Christophe Goetz, Christian Platini, Nada Eid, Jocelyne Sellies, Nadia Ouamara, Philippe Quétin
BACKGROUND: Totally implantable venous access port (TIVAP)-related infections (RIs) remain a serious health problem in cancer patients receiving an intravenous (i.v.) therapy. PATIENTS AND METHODS: The ATAPAC study was a prospective, randomized, monocentric, phase IV trial evaluating the efficacy of taurolidine lock solution versus standard saline solution for primary TIVAP-RI prevention in nonhematological cancer patients receiving i.v. chemotherapy. The primary endpoint was the TIVAP-RI incidence rate...
May 3, 2017: Oncology
https://www.readbyqxmd.com/read/28460873/long-term-therapeutic-effects-of-dextrose-prolotherapy-in-patients-with-hypermobility-of-the-temporomandibular-joint-a-single-arm-study-with-1-4-years-follow-up
#16
H Refai
The aim was to analyse the short-term and long-term therapeutic efficacy of dextrose prolotherapy for dislocation or subluxation (hypermobility) of the temporomandibular joint (TMJ). Sixty-one patients with symptomatic hypermobility of the TMJ were included in this single-arm prospective study, in which they were each given four sessions of intra-articular and pericapsular injections six weeks apart. Each injection comprised 10% dextrose/mepivacaine solution 3ml. Clinical outcomes including severity of pain on movement according to the numerical rating scale (NRS), maximal interincisal opening, clicking, and frequency of locking were measured before treatment (T1), during treatment (T2) (just before the third session of injections), at the short-term follow-up (T3) (three months after treatment), and at the long-term follow-up (T4) (1-4 years after treatment)...
April 28, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28453851/eradication-of-staphylococcus-aureus-biofilm-infections-using-synthetic-antimicrobial-peptides
#17
Marta Zapotoczna, Éanna Forde, Siobhan Hogan, Hilary Humphreys, James P O'Gara, Deirdre Fitzgerald-Hughes, Marc Devocelle, Eoghan O'Neill
Here, we demonstrate that antimicrobial peptides (AMPs) are an effective antibiofilm treatment when applied as catheter lock solutions (CLSs) against S. aureus biofilm infections. The activity of synthetic AMPs (Bac8c, HB43, P18, Omiganan, WMR, Ranalexin, and Polyphemusin) was measured against early and mature biofilms produced by methicillin-resistant S. aureus and methicillin-susceptible S. aureus isolates from patients with device-related infections grown under in vivo-relevant biofilm conditions. The cytotoxic and hemolytic activities of the AMPs against human cells and their immunomodulatory potential in human blood were also characterized...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28449854/complications-of-intramedullary-nailing-evolution-of-treatment
#18
Dirk Wähnert, Dominic Gehweiler
Intramedullary nailing of diaphyseal long bone fractures is a standard procedure in today's trauma and orthopedic surgery due to the numerous advantages (e.g. minimal invasive, limited soft tissue damage, load stability). In the last decade indications have been extended to the metaphyseal region. This was associated with problems and complications due to the reduced bone-implant interface. The changed anatomical conditions lead to decreased implant anchorage. Newly developed locking solutions overcome most of these problems...
June 2017: Injury
https://www.readbyqxmd.com/read/28438824/comparison-of-linezolid-and-vancomycin-lock-solutions-with-and-without-heparin-against-biofilm-producing-bacteria
#19
Megan K Luther, Leonard A Mermel, Kerry L LaPlante
PURPOSE: The activity of linezolid and vancomycin lock solutions against biofilm-producing strains of Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis was studied. METHODS: Two strains each of methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), and S. epidermidis, and 1 strain of vancomycin-susceptible E. faecalis and vancomycin-resistant E. faecalis were tested against vancomycin and linezolid to assess prevention of biofilm formation and eradication of these pathogens within a formed biofilm...
May 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28433011/ramped-amplitude-novel
#20
T V Can, R T Weber, J J Walish, T M Swager, R G Griffin
We present a pulsed dynamic nuclear polarization (DNP) study using a ramped-amplitude nuclear orientation via electron spin locking (RA-NOVEL) sequence that utilizes a fast arbitrary waveform generator (AWG) to modulate the microwave pulses together with samples doped with narrow-line radicals such as 1,3-bisdiphenylene-2-phenylallyl (BDPA), sulfonated-BDPA (SA-BDPA), and trityl-OX063. Similar to ramped-amplitude cross polarization in solid-state nuclear magnetic resonance, RA-NOVEL improves the DNP efficiency by a factor of up to 1...
April 21, 2017: Journal of Chemical Physics
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