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Anjan Bedi, Linda J W Shimon, Ori Gidron
Twisting linear acenes out of planarity affects their electronic and optical properties, and induces chirality. However, it is difficult to isolate the effect of twisting from the substituent effect. Moreover, many twistacenes (twisted acenes) readily racemize in solution. Here, we introduce a series of twistacenes having an anthracene backbone diagonally tethered by an n-alkyl bridge, which induces a twist of various angles. This allows us to systematically monitor the effect of twisting on electronic and optical properties...
June 15, 2018: Journal of the American Chemical Society
Daniel G Greene, Steven J Traylor, Jing Guo, Leila H Choe, Shannon Modla, Xuankuo Xu, Nripen Singh, Lye Lin Lock, Sanchayita Ghose, Zheng Jian Li, Kelvin H Lee, Norman J Wagner, Abraham M Lenhoff
Protein precipitates that arise during bioprocessing can cause manufacturing challenges but they can also aid in clearance of host-cell protein and DNA impurities. Such precipitates differ from many protein precipitates that have been studied previously in their heterogeneous composition, particularly in the presence of high concentrations of the product protein. Here we characterize the precipitates that form after neutralization of Protein A purified and viral-inactivated material of an Fc-fusion protein produced in Chinese hamster ovary (CHO) cells...
June 13, 2018: Biotechnology and Bioengineering
Freya Van Hulle, Florence Bonkain, Dieter De Clerck, Dimitri Aerden, Isabelle Vanwijn, Christian Tielemans, Karl Martin Wissing
BACKGROUND: There are few data to inform decisions about the optimal management of occluded tunneled cuffed hemodialysis catheters with thrombolytic locking solutions. The effect of dose, dwell-time, and number of administrations remains controversial. METHODS: In this retrospective single-center review of tunneled cuffed catheters used between 2010 and 2014, restoration of blood flow as well as pre- and post-pump pressures after either short (30 min) or prolonged (48-72 h) administration of 100,000 IU of urokinase locking solution was evaluated in all thrombotic dysfunctions...
June 1, 2018: Journal of Vascular Access
Hsiang-Ting Lei, Jinming Ma, Silvia Sanchez Martinez, Tamir Gonen
Recent advances in understanding intracellular amino acid transport and mechanistic target of rapamycin complex 1 (mTORC1) signaling shed light on solute carrier 38, family A member 9 (SLC38A9), a lysosomal transporter responsible for the binding and translocation of several essential amino acids. Here we present the first crystal structure of SLC38A9 from Danio rerio in complex with arginine. As captured in the cytosol-open state, the bound arginine was locked in a transitional state stabilized by transmembrane helix 1 (TM1) of drSLC38A9, which was anchored at the groove between TM5 and TM7...
June 2018: Nature Structural & Molecular Biology
Conor D Rankine, João Pedro F Nunes, Tomas Lock Feixas, Stuart Young, Derek Alan A Wann
The continued demand for gas-phase structures has led to the recommissioning of a gas electron diffractometer, formerly housed at the University of Reading. The gas electron diffractometer, now the only one of its kind in the UK, is currently housed at the University of York where it is now used routinely to determine directly structures of isolated molecules in the gas phase. The instrument has an air-heated nozzle assembly to increase the range of molecules accessible to study in the gas phase; the efficacy of this assembly is demonstrated in this article via the direct determination of the gas-phase structure of 4-(dimethylamino)benzonitrile (DMABN) at elevated temperature...
June 5, 2018: Journal of Physical Chemistry. A
Emmanuel J Camus, Luc Van Overstraeten
Displaced fractures of the distal radius often require reduction and fixation to improve outcome in active patients. The volar locking plate gained ground over pinning, which was the first surgical solution described. But pinning methods have since evolved with fewer complications. The authors present a clinical study of distal radius fracture fixation using the HK2 technique, where subchondral pins are connected to intra-focal pins. The results are satisfactory with a lower complication rate compared to other pinning methods...
June 5, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Lori Knowles, Westerly Luth, Tania Bubela
Personalized medicine (PM) aims to harness a wave of 'omics' discoveries to facilitate research and discovery of targeted diagnostics and therapies and increase the efficiency of healthcare systems by predicting and treating individual predispositions to diseases or conditions. Despite significant investment, limited progress has been made bringing PM to market. We describe the major perceived regulatory, intellectual property, and reimbursement challenges to the development, translation, adoption, and implementation of PM products into clinical care...
December 2017: Journal of Law and the Biosciences
J Chandra, L Long, N Isham, P K Mukherjee, G DiSciullo, K Appelt, M A Ghannoum
Central line associated bloodstream infections (CLABSIs) are increasingly recognized to be associated with intralumenal microbial biofilms, and effective measures for the prevention and treatment of BSI remain lacking. This report evaluates a new commercially developed antimicrobial catheter lock solution (ACL) containing trimethoprim (5 mg/ml) and ethanol (25%) and calcium Ethylenediaminetetraacetic acid (CA-EDTA) 3% for activity against bacterial and fungal biofilms using in vitro and in vivo (rabbit) catheter biofilm models...
June 4, 2018: Antimicrobial Agents and Chemotherapy
Maryam Tabatabaei Anaraki, Rudraksha Dutta Majumdar, Nicole Wagner, Ronald Soong, Vera Kovacevic, Eric J Reiner, Satyendra P Bhavsar, Xavier Ortiz Almirall, Daniel Lane, Myrna J Simpson, Hermann Heumann, Sebastian Schmidt, Andre J Simpson
In vivo nuclear magnetic resonance (NMR) spectroscopy is a particularly powerful technique, since it allows samples to be analyzed in their natural, unaltered state, criteria paramount for living organisms. In this study, a novel continuous low-volume flow system, suitable for in vivo NMR metabolomics studies, is demonstrated. The system allows for improved locking, shimming and water suppression, as well as allowing the use of trace amounts of expensive toxic contaminants or low volume of precious natural environmental samples as stressors...
June 4, 2018: Analytical Chemistry
Sudhir Bhatt, Poonam Mehta, Chen Chen, Dayle A Daines, Leonard A Mermel, Hai-Lan Chen, Michael G Kong
Antimicrobial lock solutions are important for prevention of microbial colonization and infection of long-term central venous catheters. We investigated the efficacy and safety of a novel antibiotic-free lock solution formed from gas plasma-activated disinfectant (PAD). Using a luminal biofilm model, viable cells of methicillin-resistant Staphylococcus aureus , Staphylococcus epidermidis , Pseudomonas aeruginosa , and Candida albicans in mature biofilms were reduced by 6 - 8 orders of magnitude with a PAD lock for 60 minutes...
May 29, 2018: Antimicrobial Agents and Chemotherapy
Hongliu Yang, Feng Chen, He Jiao, Han Luo, Yang Yu, Hyokyoung G Hong, Yi Li, Ping Fu, Tianlei Cui
OBJECTIVES: Catheter-related right atrial thrombosis (CRAT) is an underreported but potentially life-threatening complication associated with the use of tunneled-cuffed catheters among hemodialysis (HD) patients. Because little is known about the evidence-based guidelines for the optimal management of CRAT among HD patients, this article reports findings based on 20 patients diagnosed with CRAT after catheter replacement and anticoagulation treatment. METHODS: The article retrospectively reviews the hospital records of 20 HD patients treated in the West China Hospital with diagnosis of CRAT from March 2013 to May 2016...
May 24, 2018: Journal of Vascular Surgery
Cristina Díaz-Ruíz, Beatriz Alonso, Emilia Cercenado, Raquel Cruces, Emilio Bouza, Patricia Muñoz, María Guembe
PURPOSE: The new lipoglycopeptide dalbavancin has only been approved for acute bacterial skin and skin structure infections. However, its alternative use as a catheter lock solution could facilitate the conservative management of catheter-related bloodstream infection. Our objective was to assess the stability and activity of dalbavancin alone and in combination with heparin against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) biofilms...
May 17, 2018: Journal of Medical Microbiology
Michael Margaliot, Lars Grüne, Thomas Kriecherbauer
The master equation plays an important role in many scientific fields including physics, chemistry, systems biology, physical finance and sociodynamics. We consider the master equation with periodic transition rates. This may represent an external periodic excitation like the 24 h solar day in biological systems or periodic traffic lights in a model of vehicular traffic. Using tools from systems and control theory, we prove that under mild technical conditions every solution of the master equation converges to a periodic solution with the same period as the rates...
April 2018: Royal Society Open Science
Honggang Zhang, Tao Lyu, Lei Bi, Grant Tempero, David P Hamilton, Gang Pan
Combating hypoxia/anoxia is an increasingly common need for restoring natural waters suffering from eutrophication. Oxygen nanobubble modified natural particles were investigated for mitigating hypoxia/anoxia at the sediment-water interface (SWI) in a simulated column experiment. By adding oxygen nanobubble modified zeolites (ONMZ) and local soils (ONMS), the oxygen nanobubble concentrations (105 -107  particles/mL) were several orders of magnitude higher in the water than the original water solution (104  particles/mL) within 24 h...
May 10, 2018: Science of the Total Environment
Yi-Ying Tsai, Gwo-Ching Chang, Ing-Shiou Hwang
Joint constraint interferes with the coordinative structure in joint movements used to optimize postural stability. This study aimed to investigate changes in postural synergy when the ankle joints were bilaterally braced during a stabilometer stance. Twenty-four young adults stood on a stabilometer plate while wearing a pair of ankle-foot orthoses, which were either unlocked or locked to restrict ankle motion (the ankle constraint (AC) and non-constraint (NC) conditions). Although ankle constraint did not significantly affect the dynamics of the stabilometer movements, the size and regularity of the first principal component (PC1), which explained more than 80% of the variance of joint movements in the lower limb, were increased...
May 9, 2018: Human Movement Science
Luigi Rossi, Pasquale Libutti, Francesco Casucci, Piero Lisi, Annalisa Teutonico, Carlo Basile, Carlo Lomonte
Catheter-related right atrial thrombosis is a severe and life-threatening complication of central venous catheters in both adult and young patients. Catheter-related right atrial thrombosis can occur with any type of central venous catheters, utilized either for hemodialysis or infusion. Up to 30% of patients with central venous catheter are estimated to be affected by catheter-related right atrial thrombosis; however, neither precise epidemiological data nor guidelines regarding medical or surgical treatment are available...
May 1, 2018: Journal of Vascular Access
Missael Antonio Arroyo Negrete, Kazimierz Wrobel, Francisco Javier Acevedo Aguilar, Eunice Yanez Barrientos, Alma Rosa Corrales Escobosa, Katarzyna Wrobel
OBJECTIVE: The goal of this work was to set up a high throughput procedure for the determination of fatty acid methyl esters (FAMEs) in cosmetic castor oils using flow injection - electrospray ionization - high resolution mass spectrometry, and to demonstrate the need of such analysis for the quality control purposes. METHODS: The sample aliquot was mixed with isooctane:chloroform (1:1) and submitted to transesterification; the obtained FAMEs were appropriately diluted using water:isopropanol:acetonitrile (20:50:30) with addition of sodium formate which served as an internal standard, lock mass calibrant and promoted the formation of sodium adducts during electrospray ionization (ESI)...
May 9, 2018: International Journal of Cosmetic Science
Aline Haas de Mello, Rosiane de Bona Schraiber, Mariana Pereira de Souza Goldim, Michelle Lima Garcez, Maria Luiza Gomes, Gustavo de Bem Silveira, Rubya Pereira Zaccaron, Patrícia Fernanda Schuck, Josiane Budni, Paulo Cesar Lock Silveira, Fabricia Petronilho, Gislaine Tezza Rezin
This study evaluated the effects of omega-3 on inflammation, oxidative stress, and energy metabolism parameters in the brain of mice subjected to high-fat diet-induced obesity model. Body weight and visceral fat weight were evaluated as well. Male Swiss mice were divided into control (purified low-fat diet) and obese (purified high-fat diet). After 6 weeks, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + OMEGA-3. Fish oil (400 mg/kg/day) or saline solution was administrated orally, during 4 weeks...
May 4, 2018: Molecular Neurobiology
C Gudiol, S Nicolae, C Royo-Cebrecos, M Aguilar-Guisado, I Montero, C Martín-Gandul, M Perayre, D Berbel, M Encuentra, M Arnan, J M Cisneros-Herreros, J Carratalà
BACKGROUND: Catheter-related bloodstream infection (CRBSI) is one of the most frequent complications in patients with cancer who have central venous catheters (CVCs) implanted and is associated with substantial morbidity and mortality. Taurolidine is a non-antibiotic agent with broad-spectrum antimicrobial activity, which has been used as a lock solution to prevent CRBSI in some settings. However, little is known about its usefulness in high-risk adult neutropenic patients with cancer...
May 2, 2018: Trials
Tomislav Milekovic, Anish A Sarma, Daniel Bacher, John D Simeral, Jad Saab, Chethan Pandarinath, Brittany L Sorice, Christine Blabe, Erin M Oakley, Kathryn R Tringale, Emad Eskandar, Sydney S Cash, Jaimie M Henderson, Krishna V Shenoy, John P Donoghue, Leigh R Hochberg
Restoring communication for people with locked-in syndrome remains a challenging clinical problem without a reliable solution. Recent studies have shown that people with paralysis can use brain-computer interfaces (BCIs) based on intracortical spiking activity to efficiently type messages. However, due to neuronal signal instability, most intracortical BCIs have required frequent calibration and continuous assistance of skilled engineers to maintain performance. Here, an individual with locked-in syndrome due to brainstem stroke and an individual with tetraplegia secondary to amyotrophic lateral sclerosis (ALS) used a simple communication BCI based on intracortical local field potentials (LFPs) for 76 and 138 days, respectively, without recalibration and without significant loss of performance...
April 25, 2018: Journal of Neurophysiology
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