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https://www.readbyqxmd.com/read/28433011/ramped-amplitude-novel
#1
T V Can, R T Weber, J J Walish, T M Swager, R G Griffin
We present a pulsed dynamic nuclear polarization (DNP) study using a ramped-amplitude nuclear orientation via electron spin locking (RA-NOVEL) sequence that utilizes a fast arbitrary waveform generator (AWG) to modulate the microwave pulses together with samples doped with narrow-line radicals such as 1,3-bisdiphenylene-2-phenylallyl (BDPA), sulfonated-BDPA (SA-BDPA), and trityl-OX063. Similar to ramped-amplitude cross polarization in solid-state nuclear magnetic resonance, RA-NOVEL improves the DNP efficiency by a factor of up to 1...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28429519/the-incidence-and-costs-of-bacteremia-due-to-lack-of-gentamicin-lock-solutions-for-dialysis-catheters
#2
Tze Liang Goh, Jason Wei, David Semple, John Collins
The use of antibiotic lock solutions as prophylaxis for catheter-associated blood stream infection (CRBSI) has been shown to be effective in previous randomized controlled trials. However, the cost-effectiveness of this approach had not been studied. In 2012, the routine gentamicin-heparin lock solution used in Auckland City Hospital was withdrawn from the market, leading to a change to heparin-only lock. This was then replaced with gentamicin-citrate lock in 2014. This situation allowed review of the CRBSI rate and financial impact of different catheter lock solutions...
June 2017: Nephrology
https://www.readbyqxmd.com/read/28424515/structure-and-allosteric-inhibition-of-excitatory-amino-acid-transporter-1
#3
Juan C Canul-Tec, Reda Assal, Erica Cirri, Pierre Legrand, Sébastien Brier, Julia Chamot-Rooke, Nicolas Reyes
Human members of the solute carrier 1 (SLC1) family of transporters take up excitatory neurotransmitters in the brain and amino acids in peripheral organs. Dysregulation of the function of SLC1 transporters is associated with neurodegenerative disorders and cancer. Here we present crystal structures of a thermostabilized human SLC1 transporter, the excitatory amino acid transporter 1 (EAAT1), with and without allosteric and competitive inhibitors bound. The structures reveal architectural features of the human transporters, such as intra- and extracellular domains that have potential roles in transport function, regulation by lipids and post-translational modifications...
April 19, 2017: Nature
https://www.readbyqxmd.com/read/28416559/a-novel-non-antibiotic-nitroglycerin-based-catheter-lock-solution-for-the-prevention-of-intraluminal-central-venous-catheter-infections-in-cancer-patients
#4
Anne-Marie Chaftari, Ray Hachem, Ariel Szvalb, Mahnaz Taremi, Bruno Granwehr, George Michael Viola, Amin Sapna, Andrew Assaf, Numan Yazan, Pankil Shah, Ketevan Gasitashvili, Elizabeth Natividad, Ying Jiang, Rebecca Slack, Ruth Reitzel, Joel Rosenblatt, Elie Mouhayar, Issam Raad
Background: For long-term central lines (CL), the lumen is the major source of central line associated bloodstream infections (CLABSI). Current standard of care for maintaining catheter patency includes flushing the CL with saline or heparin. Neither agent has any antimicrobial activity. Furthermore heparin may enhance staphylococcal biofilm formation. We evaluated the safety and efficacy of a novel non-antibiotic catheter lock solution for the prevention of CLABSI.Patients and Methods: Between November 2015, and February 2016, we enrolled 60 patients with hematologic malignancies who had peripherally inserted central catheter (PICC) to receive the study lock solution...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28415937/heparinized-saline-versus-normal-saline-for-maintaining-peripheral-venous-catheter-patency-in-china-an-open-label-randomized-controlled-study
#5
Lichun Xu, Yan Hu, Xiaojin Huang, Jianguo Fu, Jinhui Zhang
Objective To evaluate the effects of heparin saline versus normal saline as locking solution for maintaining patency in peripheral venous catheters in Chinese patients. Methods This open-label, randomized controlled study was conducted in two hepatobiliary surgery wards, where patients received identical treatments, at a tertiary referral hospital. Patients were randomly divided into a normal saline group (NS, 3 ml) or a heparin saline group (HS, 50 IU/ml, 3 ml) for catheter sealing. Results The study enrolled 286 patients and 609 peripheral venous catheters were included in the analysis...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28407499/alleviation-of-heavy-metal-toxicity-and-phytostimulation-of-brassica-campestris-l-by-endophytic-mucor-sp-mhr-7
#6
Mahwish Zahoor, Muhammad Irshad, Hazir Rahman, Muhammad Qasim, Sahib Gul Afridi, Muhammad Qadir, Anwar Hussain
Heavy metal (HM) pollution is of great concern in countries like Pakistan where a huge proportion of human population is exposed to it. These toxic metals are making their way from water bodies to soil where it not only interferes with plant growth and development but also initiates serious health issues in human consuming the produce of such soils. Bioremediation is one of the most viable and efficient solution for the problem. Purpose of the current study was to isolate endophytic fungi from plants grown on HM contaminated soil and screen them for their ability to tolerate multiple HM including chromium (Cr(6+)), manganese (Mn(2+)), cobalt (Co(2+)), copper (Cu(2+)) and zinc (Zn(2+))...
April 10, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28380977/several-nanosecond-nd-yvo-sub-4-sub-lasers-q-switched-by-two-dimensional-materials-tungsten-disulfide-molybdenum-disulfide-and-black-phosphorous
#7
Huan Liu, Zhe Sun, Xi Wang, Yonggang Wang, Guanghua Cheng
Graphene-like two-dimensional (2D) materials have shown remarkable broadband saturable absorption properties. These materials were successfully applied into mode locked lasers to generate laser pulses with the pulse duration from picosecond to femtosecond. However, these novel materials have not shown good performance as far in another important aspect: Q-switched lasers. Solid-state or fiber lasers Q-switched with broadband absorbers usually generated pulses of one hundred nanosecond to several microsecond, which show weak competitiveness compared to traditional absorbers such as Cr: YAG and semiconductor saturable absorption mirror (SESAM)...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28362363/determining-the-chemical-composition-of-corrosion-inhibitor-metal-interfaces-with-xps-minimizing-post-immersion-oxidation
#8
Monika S Walczak, Perla Morales-Gil, Turia Belashehr, Kiran Kousar, Paulina Arellanes Lozada, Robert Lindsay
An approach for acquiring more reliable X-ray photoelectron spectroscopy data from corrosion inhibitor/metal interfaces is described. More specifically, the focus is on metallic substrates immersed in acidic solutions containing organic corrosion inhibitors, as these systems can be particularly sensitive to oxidation following removal from solution. To minimize the likelihood of such degradation, samples are removed from solution within a glove box purged with inert gas, either N2 or Ar. The glove box is directly attached to the load-lock of the ultra-high vacuum X-ray photoelectron spectroscopy instrument, avoiding any exposure to the ambient laboratory atmosphere, and thus reducing the possibility of post immersion substrate oxidation...
March 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28321903/spin-lock-imaging-of-exogenous-exchange-based-contrast-agents-to-assess-tissue-ph
#9
Zhongliang Zu, Hua Li, Xiaoyu Jiang, John C Gore
PURPOSE: Some X-ray contrast agents contain exchangeable protons that give rise to exchange-based effects on MRI, including chemical exchange saturation transfer (CEST). However, CEST has poor specificity to explicit exchange parameters. Spin-lock sequences at high field are also sensitive to chemical exchange. Here, we evaluate whether spin-locking techniques can detect the contrast agent iohexol in vivo after intravenous administration, and their potential for measuring changes in tissue pH...
March 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28317370/two-dimensional-ch3nh3pbi3-perovskite-nanosheets-for-ultrafast-pulsed-fiber-lasers
#10
Pengfei Li, Yao Chen, Tieshan Yang, Ziyu Wang, Han Lin, Yanhua Xu, Lei Li, Haoran Mu, Bannur Nanjunda Shivananju, Yupeng Zhang, Qinglin Zhang, Anlian Pan, Shaojuan Li, Dingyuan Tang, Baohua Jia, Han Zhang, Qiaoliang Bao
Even though the nonlinear optical effects of solution processed organic-inorganic perovskite films have been studied, the nonlinear optical properties in two-dimensional (2D) perovskites, especially their applications for ultrafast photonics, are largely unexplored. In comparison to bulk perovskite films, 2D perovskite nanosheets with small thicknesses of a few unit cells are more suitable for investigating the intrinsic nonlinear optical properties because bulk recombination of photocarriers and the nonlinear scattering are relatively small...
March 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28297055/any-use-for-alternative-lock-solutions-in-the-prevention-of-catheter-related-blood-stream-infections
#11
Laura Labriola, Jean-Michel Pochet
The prevention of catheter-related blood stream infections (CRBSI) in hemodialysis (HD) patients remains a challenge because of high morbidity and mortality associated to CRBSI. Alternative locking solutions (ALS) containing an antithrombotic substance with additional antimicrobial or antibiofilm properties (citrate, ethylenediaminetetraacetic acid [EDTA], 70% ethanol, thrombolytics) with or without the addition of molecules with specific antimicrobial activity (antibiotics, taurolidine, paraben-methylene-blue) has been proposed with the aim to prevent or eradicate intraluminal biofilm colonization and subsequent CRBSI...
March 6, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28292637/patterns-and-predictors-of-peripherally-inserted-central-catheter-occlusion-the-3p-o-study
#12
Shawna N Smith, Nancy Moureau, Valerie M Vaughn, Tanya Boldenow, Scott Kaatz, Paul J Grant, Steven J Bernstein, Scott A Flanders, Vineet Chopra
PURPOSE: To evaluate patterns and predictors of peripherally inserted central catheter (PICC)-related occlusion. MATERIALS AND METHODS: Data from a multihospital study were used to examine factors associated with PICC occlusion. Occlusion was defined if documented in the medical record or when tissue plasminogen activator was administered for occlusion-related concerns. Mixed-effects logistic regression was used to predict occlusion, controlling for patient-, provider-, device-, and hospital-level characteristics...
March 11, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28287523/use-of-sacrificial-nanoparticles-to-remove-the-effects-of-shot-noise-in-contact-holes-fabricated-by-e-beam-lithography
#13
Shankar B Rananavare, Moshood K Morakinyo
Nano-patterns fabricated with extreme ultraviolet (EUV) or electron-beam (E-beam) lithography exhibit unexpected variations in size. This variation has been attributed to statistical fluctuations in the number of photons/electrons arriving at a given nano-region arising from shot-noise (SN). The SN varies inversely to the square root of a number of photons/electrons. For a fixed dosage, the SN is larger in EUV and E-beam lithographies than for traditional (193 nm) optical lithography. Bottom-up and top-down patterning approaches are combined to minimize the effects of shot noise in nano-hole patterning...
February 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28271002/coherence-properties-of-short-cavity-swept-lasers
#14
Bart Johnson, Walid Atia, Mark Kuznetsov, Brian D Goldberg, Peter Whitney, Dale C Flanders
It has been shown theoretically and experimentally that short cavity swept lasers are passively mode locked. We develop a mathematical model of these lasers and the light field solutions are used to predict the coherence length and coherence revival behavior. The calculations compare favorably with data from a 990-1100 nm laser swept at 100 kHz suitable for optical coherence tomography applications.
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28268487/optimal-weighted-averaging-of-event-related-activity-from-acquisitions-with-artifacts
#15
Luca Vollero, Sara Petrichella, Giulio Innello
In several biomedical applications that require the signal processing of biological data, the starting procedure for noise reduction is the ensemble averaging of multiple repeated acquisitions (trials). This method is based on the assumption that each trial is composed of two additive components: (i) a time-locked activity related to some sensitive/stimulation phenomenon (ERA, Event Related Activity in the following) and (ii) a sum of several other non time-locked background activities. The averaging aims at estimating the ERA activity under very low Signal to Noise and Interference Ratio (SNIR)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28254401/liquor-legislation-last-drinks-and-lockouts-the-newcastle-australia-solution
#16
G R Hoffman, K Palazzi, B K Oteng Boateng, C Oldmeadow
The aim of this study was to determine whether the regional implementation of prohibitive liquor legislation, introduced in order to limit the sale of and access to alcohol, can lead to a sustained reduction in the incidence of assault occasioning facial injury, as seen in patients presenting to a level 1 trauma hospital. A retrospective observational cohort study was conducted to document patients who were identified as an acute hospital presentation of assault occasioning facial injury. The period of study was 2003-2015; this ensured a similar period of time before and after the implementation of the legislation in 2008...
February 18, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28243767/practical-considerations-for-investigation-of-protein-conformational-dynamics-by-15-n-r-1%C3%AF-relaxation-dispersion
#17
Erik Walinda, Daichi Morimoto, Masahiro Shirakawa, Kenji Sugase
It is becoming increasingly apparent that proteins are not static entities and that their function often critically depends on accurate sampling of multiple conformational states in aqueous solution. Accordingly, the development of methods to study conformational states in proteins beyond their ground-state structure ("excited states") has crucial biophysical importance. Here we investigate experimental schemes for optimally probing chemical exchange processes in proteins on the micro- to millisecond timescale by (15)N R 1ρ relaxation dispersion...
February 28, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28241410/inertial-navigation-system-doppler-velocity-log-ins-dvl-fusion-with-partial-dvl-measurements
#18
Asaf Tal, Itzik Klein, Reuven Katz
The Technion autonomous underwater vehicle (TAUV) is an ongoing project aiming to develop and produce a small AUV to carry on research missions, including payload dropping, and to demonstrate acoustic communication. Its navigation system is based on an inertial navigation system (INS) aided by a Doppler velocity log (DVL), magnetometer, and pressure sensor (PS). In many INSs, such as the one used in TAUV, only the velocity vector (provided by the DVL) can be used for aiding the INS, i.e., enabling only a loosely coupled integration approach...
February 22, 2017: Sensors
https://www.readbyqxmd.com/read/28237334/functional-involvement-of-protein-kinase-c-rho-kinase-and-trpc3-decreases-while-plc-increases-with-advancement-of-pregnancy-in-mediating-oxytocin-induced-myometrial-contractions-in-water-buffaloes-bubalus-bubalis
#19
Abhishek Sharma, Udayraj P Nakade, Soumen Choudhury, Satish Kumar Garg
Present study unravels the involvement of different calcium signaling pathways in oxytocin-induced contractions in myometrium of non-pregnant and pregnant buffaloes during early and mid-pregnancy stages. Uteri of pregnant animals were more sensitive than of non-pregnant buffaloes. Phasic contractions and frequency of contraction significantly increased with advancement of pregnancy, while tonic contractions non-significantly and amplitude significantly decreased from six months pregnancy onward. Oxytocin produced concentration-dependent-contraction on isolated myometrial strips of pregnant and non-pregnant buffaloes and the dose response curves (DRCs) of oxytocin were significantly (P < 0...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28226661/optimal-weighted-averaging-of-event-related-activity-from-acquisitions-with-artifacts
#20
Luca Vollero, Sara Petrichella, Giulio Innello, Luca Vollero, Sara Petrichella, Giulio Innello, Luca Vollero, Sara Petrichella, Giulio Innello
In several biomedical applications that require the signal processing of biological data, the starting procedure for noise reduction is the ensemble averaging of multiple repeated acquisitions (trials). This method is based on the assumption that each trial is composed of two additive components: (i) a time-locked activity related to some sensitive/stimulation phenomenon (ERA, Event Related Activity in the following) and (ii) a sum of several other non time-locked background activities. The averaging aims at estimating the ERA activity under very low Signal to Noise and Interference Ratio (SNIR)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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