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https://www.readbyqxmd.com/read/28812792/a-case-for-open-network-health-systems-systems-as-networks-in-public-mental-health
#1
Michael Grant Rhodes, Marten W de Vries
Increases in incidents involving so-called confused persons have brought attention to the potential costs of recent changes to public mental health (PMH) services in the Netherlands. Decentralized under the (Community) Participation Act (2014), local governments must find resources to compensate for reduced central funding to such services or "innovate." But innovation, even when pressure for change is intense, is difficult. This perspective paper describes experience during and after an investigation into a particularly violent incident and murder...
January 8, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28809638/-four-corner-arthrodesis-of-the-wrist-with-dorsal-circular-plate-a-retrospective-monocentric-study
#2
T Zatrapa, D Veigl, J Pech, I Landor, M Šimková
PURPOSE OF THE STUDY Our study aimed to evaluate a group of patients who in the period from 2005 to 2014 underwent a four-corner arthrodesis of the wrist in our department. We also wanted to verify the hypothesis as to whether the use of conventional dorsal plate without the application of bone grafts leads to comparable results as the use of dorsal locking plates and routine application of bone grafts. MATERIAL AND METHODS Throughout the years 2005 to 2014 the four-corner arthrodesis of the wrist was performed in our department in a total of 62 patients, in two cases bilaterally...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28806225/preventing-retained-central-venous-catheter-guidewires-a-randomized-controlled-simulation-study-using-a-human-factors-approach
#3
Maryanne Z A Mariyaselvam, Ken R Catchpole, David K Menon, Arun K Gupta, Peter J Young
BACKGROUND: Retained central venous catheter guidewires are never events. Currently, preventative techniques rely on clinicians remembering to remove the guidewire. However, solutions solely relying upon humans to prevent error inevitably fail. A novel locked procedure pack was designed to contain the equipment required for completing the procedure after the guidewire should have been removed: suture, suture holder, and antimicrobial dressings. The guidewire is used as a key to unlock the pack and to access the contents; thereby, the clinician must remove the guidewire from the patient to complete the procedure...
August 11, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28800748/short-term-treatment-with-taurolidine-is-associated-with-liver-injury
#4
René Fahrner, Anika Möller, Adrian T Press, Andreas Kortgen, Michael Kiehntopf, Falk Rauchfuss, Utz Settmacher, Alexander S Mosig
BACKGROUND: Taurolidine has been used for peritonitis, oncological and catheter-lock treatment because of its anti-inflammatory properties. It has been suggested that taurolidine has no severe side-effects, but after long-term use morphological and functional changes of the liver were reported. The aim of this study was to investigate the effect of short-term use of taurolidine on the liver. METHODS: In HepaRG cell cultures and on a novel liver biochip dose-dependent effects of taurolidine treatment on hepatocyte adherence and cell viability was investigated...
August 11, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28793993/taurolidine-citrate-heparin-lock-reduces-catheter-related-bloodstream-infections-in-intestinal-failure-patients-dependent-on-home-parenteral-support-a-randomized-placebo-controlled-trial
#5
Siri Tribler, Christopher F Brandt, Anne H Petersen, Jørgen H Petersen, Kristian A Fuglsang, Michael Staun, Per Broebech, Claus E Moser, Palle B Jeppesen
Background: In patients with intestinal failure who are receiving home parenteral support (HPS), catheter-related bloodstream infections (CRBSIs) inflict health impairment and high costs.Objective: This study investigates the efficacy and safety of the antimicrobial catheter lock solution, taurolidine-citrate-heparin, compared with heparin 100 IE/mL on CRBSI occurrence.Design: Forty-one high-risk patients receiving HPS followed in a tertiary HPS unit were randomly assigned in a double-blinded, placebo-controlled trial...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28774123/floating-hydrogel-with-self-generating-micro-bubbles-for-intravesical-instillation
#6
Tingsheng Lin, Xiaozhi Zhao, Yifan Zhang, Huibo Lian, Junlong Zhuang, Qing Zhang, Wei Chen, Wei Wang, Guangxiang Liu, Suhan Guo, Jinhui Wu, Yiqiao Hu, Hongqian Guo
Intravesical instillation is the main therapy for bladder cancer and interstitial cystitis. However, most drug solutions are eliminated from bladder after the first voiding of urine. To solve this problem, we proposed a floating hydrogel with self-generating micro-bubbles as a new delivery system. It floated in urine, avoiding the urinary obstruction and bladder irritation that ordinary hydrogels caused. In this study, we abandoned traditional gas-producing method like chemical decomposition of NaHCO₃, and used the foamability of Poloxamer 407 (P407) instead...
December 12, 2016: Materials
https://www.readbyqxmd.com/read/28770258/a-platform-agnostic-remote-desktop-system-for-screen-reading
#7
Syed Masum Billah, Vikas Ashok, Donald E Porter, I V Ramakrishnan
Remote desktop technology, the enabler of access to applications hosted on remote hosts, relies primarily on scraping the pixels on the remote screen and redrawing them as a simple bitmap on the client's local screen. Such a technology will simply not work with screen readers since the latter are innately tied to reading text. Since screen readers are locked-in to a specific OS platform, extant solutions that enable remote access with screen readers such as NVDARemote and JAWS Tandem require homogeneity of OS platforms at both the client and remote sites...
October 2016: ASSETS Association for Computing Machinery
https://www.readbyqxmd.com/read/28755609/a-resettable-and-reprogrammable-keypad-lock-based-on-electrochromic-prussian-blue-films-and-biocatalysis-of-immobilized-glucose-oxidase-in-a-bipolar-electrode-system
#8
Xue Yu, Jiying Liang, Tiangang Yang, Mengjie Gong, Dongman Xi, Hongyun Liu
Herein, a resettable and reprogrammable biomolecular keypad lock on the basis of a closed bipolar electrode (BPE) system was established. In this system, one ITO electrode with immobilized chitosan (CS) and glucose oxidase (GOD), designated as CS-GOD, acted as one pole of BPE in the sensing cell; another ITO with electrodeposited Prussian blue (PB) films as the other pole in the reporting cell. The addition of ascorbic acid (AA) in the sensing cell with driving voltage (Vtot) at +2.5V would make the PB films become Prussian white (PW) in the reporting cell, accompanied by the color change from blue to nearly transparent...
July 22, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28755476/regulation-of-the-interaction-between-the-neuronal-bin1-isoform-1-and-tau-proteins-role-of-the-sh3-domain
#9
Idir Malki, François-Xavier Cantrelle, Yoann Sottejeau, Guy Lippens, Jean-Charles Lambert, Isabelle Landrieu
Bridging integrator 1 bin1 gene is a genetic determinant of Alzheimer's disease and has been reported to modulate Alzheimer's pathogenesis through pathway(s) involving Tau. The functional impact of Tau/BIN1 interaction as well as the molecular details of this interaction are still not fully resolved. As a consequence, how BIN1 through its interaction with Tau affects Alzheimer's disease risk is also still not determined. To progress in this understanding, interaction of Tau with two BIN1 isoforms was investigated using Nuclear Magnetic Resonance spectroscopy...
July 29, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28752182/the-challenging-surgical-treatment-of-closed-distal-humerus-fractures-in-elderly-and-octogenarian-patients-radiographic-and-functional-outcomes-with-a-minimum-follow-up-of-24%C3%A2-months
#10
Carlo Biz, Silvano Pierluigi Sperotto, Nicola Maschio, Matteo Borella, Claudio Iacobellis, Pietro Ruggieri
INTRODUCTION: The main purpose of this retrospective, non-randomized, case series study was to evaluate the clinical and radiographic outcomes of distal humerus fractures (DHFs) in a consecutive series of elderly patients operatively treated by two surgeons, and second, to identify proper indications for two elderly age ranges and two fracture pattern groups. MATERIALS AND METHODS: From January 2009 to June 2014, 51 patients (pts) underwent open reduction and internal fixation (ORIF) using the locking compression plate (LCP) distal humerus plate (DHP) system at our institution...
July 27, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28743701/correction-for-chaftari-et-al-a-novel-nonantibiotic-nitroglycerin-based-catheter-lock-solution-for-prevention-of-intraluminal-central-venous-catheter-infections-in-cancer-patients
#11
Anne-Marie Chaftari, Ray Hachem, Ariel Szvalb, Mahnaz Taremi, Bruno Granwehr, George Michael Viola, Sapna Amin, Andrew Assaf, Yazan Numan, Pankil Shah, Ketevan Gasitashvili, Elizabeth Natividad, Ying Jiang, Rebecca Slack, Ruth Reitzel, Joel Rosenblatt, Elie Mouhayar, Issam Raad
No abstract text is available yet for this article.
August 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28730438/x-aptamer-selection-and-validation
#12
Ganesh L Lokesh, Hongyu Wang, Curtis H Lam, Varatharasa Thiviyanathan, Nancy Ward, David G Gorenstein, David E Volk
Aptamers and second generation analogs, such as X-Aptamers (XAs), SOMAmers, locked nucleic acids (LNAs), and others are increasingly being used for molecular pathway targeting, biomarker discovery, or disease diagnosis by interacting with protein targets on the surface of cells or in solution. Such targeting is being used for imaging, diagnostic evaluation, interference of protein function, or delivery of therapeutic agents. Selection of aptamers using the original SELEX method is cumbersome and time-consuming, often requiring 10-15 rounds of selection, and provides aptamers with a limited number of functional groups, namely four bases of DNA or RNA, although newer SELEX methods have increased this diversity...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28710972/epidemiology-diagnosis-prevention-and-treatment-of-catheter-related-thrombosis-in-children-and-adults
#13
REVIEW
Lisa Baumann Kreuziger, Julie Jaffray, Marc Carrier
In this narrative review, the epidemiology, diagnosis, prevention strategies, and management of catheter-related thrombosis are outlined. Central venous catheters have significantly improved the quality of life of patients requiring chemotherapy, parenteral nutrition, and chronic transfusions. Catheter-related thrombosis (CRT) complicates between 1-5% of inserted catheters, with incidence varying between patient population, catheter type, and vein cannulated. Strategies to prevent CRT, including anticoagulation and locking solutions, have largely been ineffective...
July 4, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28707877/free-energy-driven-lock-open-assembly-based-optical-dna-sensor-for-cancer-related-microrna-detection-with-a-shortened-time-to-result
#14
Xiyu Zhu, Ruoyu Wang, Xiaohong Zhou, Hanchang Shi
Quantification of cancer biomarker microRNAs (miRs) by exquisitely designed biosensors with a short time-to-result is of great clinical significance. With immobilized capture probes (CPs) and fluorescent-labeled signal probes (SPs), surface-involved sandwich-type (SST) biosensors serve as powerful tools for rapid, highly sensitive, and selective detection of miR in complex matrices as opposed to the conventional techniques. One key challenge for such SST biosensors is the existence of false-negative signals when the amount of miRs exceeds SPs in solution phase for a surface with a limited number of CP...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28707742/intramolecular-locked-dithioalkylbithiophene-based-semiconductors-for-high-performance-organic-field-effect-transistors
#15
Sureshraju Vegiraju, Bo-Chin Chang, Pragya Priyanka, Deng-Yi Huang, Kuan-Yi Wu, Long-Huan Li, Wei-Chieh Chang, Yi-Yo Lai, Shao-Huan Hong, Bo-Chun Yu, Chien-Lung Wang, Wen-Jung Chang, Cheng-Liang Liu, Ming-Chou Chen, Antonio Facchetti
New 3,3'-dithioalkyl-2,2'-bithiophene (SBT)-based small molecular and polymeric semiconductors are synthesized by end-capping or copolymerization with dithienothiophen-2-yl units. Single-crystal, molecular orbital computations, and optical/electrochemical data indicate that the SBT core is completely planar, likely via S(alkyl)⋯S(thiophene) intramolecular locks. Therefore, compared to semiconductors based on the conventional 3,3'-dialkyl-2,2'-bithiophene, the resulting SBT systems are planar (torsional angle <1°) and highly π-conjugated...
July 14, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28700211/polyphenolic-polymersomes-of-temperature-sensitive-poly-n-vinylcaprolactam-block-poly-n-vinylpyrrolidone-for-anticancer-therapy
#16
Veronika Kozlovskaya, Fei Liu, Bing Xue, Fahim Ahmad, Aaron Alford, Mohammad Saeed, Eugenia Kharlampieva
We report a versatile synthesis for polyphenolic polymersomes of controlled submicron (<500 nm) size for intracellular delivery of high and low molecular weight compounds. The nanoparticles are synthesized by stabilizing the vesicular morphology of thermally responsive poly(N-vinylcaprolactam)n-b-poly(N-vinylpyrrolidone)m (PVCLn-PVPONm) diblock copolymers with tannic acid (TA), a hydrolyzable polyphenol, via hydrogen bonding at a temperature above the copolymer's lower critical solution temperature (LCST)...
July 24, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28692746/noncovalent-se%C3%A2-%C3%A2-%C3%A2-o-conformational-locks-for-constructing-high-performing-optoelectronic-conjugated-polymers
#17
Tao Dong, Lei Lv, Linlin Feng, Yu Xia, Wei Deng, Pan Ye, Bei Yang, Shang Ding, Antonio Facchetti, Huanli Dong, Hui Huang
Noncovalent conformational locks are broadly employed to construct highly planar π-conjugated semiconductors exhibiting substantial charge transport characteristics. However, current chalcogen-based conformational lock strategies for organic semiconductors are limited to S···X (X = O, N, halide) weak interactions. An easily accessible (minimal synthetic steps) and structurally planar selenophene-based building block, 1,2-diethoxy-1,2-bisselenylvinylene (DESVS), with novel Se···O noncovalent conformational locks is designed and synthesized...
July 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28689878/systematic-review-of-antimicrobial-lock-therapy-for-prevention-of-central-line-associated-bloodstream-infections-in-adult-and-pediatric-cancer-patients
#18
REVIEW
LeAnn B Norris, Farah Kablaoui, Maggie K Brilhart, P Brandon Bookstaver
BACKGROUND: Central venous catheter (CVC) use is commonplace in cancer patients. Antimicrobial lock therapy (ALT), the instillation of a concentrated antimicrobial solution into the catheter lumen, is one method for preventing infection among CVCs. This systematic review discusses the effectiveness and safety of prophylactic ALT in cancer patients with CVCs. METHODS: A literature search was performed using the Medline database and Google Scholar from inception until April 2016...
July 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28677081/the-role-of-impairment-of-mesenchymal-stem-cell-function-in-osteoporotic-bone-fracture-healing
#19
Lihai Zhang, Saeed Miramini, Martin Richardson, Priyan Mendis, Peter Ebeling
With demographic change and increasing life expectancy, osteoporotic fractures have become one of the most prevalent trauma conditions seen in daily clinical practice. A variety of factors are known to affect the rate of healing in osteoporotic conditions (e.g. both biochemical and biomechanical environment of callus cells). However, the influence of impairment of mesenchymal stem cell function in the osteoporotic condition on bone fracture healing has not been fully understood. In the present study, we develop a mathematical model that quantifies the change in biological processes within the fracture callus as a result of osteoporosis...
July 4, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28665944/molecular-mechanics-of-staphylococcus-aureus-adhesin-cna-and-the-inhibition-of-bacterial-adhesion-by-stretching-collagen
#20
Ali Madani, Kiavash Garakani, Mohammad R K Mofrad
Bacterial adhesion to collagen, the most abundant protein in humans, is a critical step in the initiation and persistence of numerous bacterial infections. In this study, we explore the collagen binding mechanism of the multi-modular cell wall anchored collagen adhesin (CNA) in Staphylococcus aureus and examine how applied mechanical forces can modulate adhesion ability. The common structural-functional elements and domain organization of CNA are present across over 50 genera of bacteria. Through the use of molecular dynamics models and normal mode analysis, we shed light on the CNA's structural and conformational dynamics and its interactions with collagen that lead to collagen binding...
2017: PloS One
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