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Oct angiography glaucoma

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https://www.readbyqxmd.com/read/28631244/optical-coherence-tomography-angiography-in-pre-perimetric-open-angle-glaucoma
#1
Gilda Cennamo, Daniela Montorio, Nunzio Velotti, Federica Sparnelli, Michele Reibaldi, Giovanni Cennamo
PURPOSE: To evaluate the diagnostic efficacy of optical coherence tomography (OCT) angiography, in patients with pre-perimetric open-angle glaucoma. METHODS: Thirty-eight consecutive eyes of 26 patients with pre-perimetric open-angle glaucoma and 48 normal eyes of 32 controls were included in this prospective study. We evaluated OCT angiography, spectral-domain OCT and visual fields parameters. Differences between controls and patients and between OCT angiography parameters and traditional glaucoma measurements were evaluated...
June 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28603574/central-retinal-vein-occlusion-in-younger-swedish-adults-case-reports-and-review-of-the-literature
#2
Elisabeth Wittström
PURPOSE: To investigate associated systemic diseases, other conditions, visual outcome, ocular complications and treatment in Swedish patients younger than 50 years with central retinal vein occlusion (CRVO) and reviewing the literature. METHODS: Twenty-two patients with CRVO, younger than 50 years, were examined with full-field electroretinography (ERG) within 3 months after a thrombotic event, or were periodically examined and were observed for at least 6 months...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28599333/-macular-edema-in-uveitis-steroids-or-vegf-inhibitors
#3
Carsten Heinz, Arnd Heiligenhaus
Macular edema in uveitis patients is certainly the most frequent complication leading to a permanent and irreversible reduction in vision during the course of the disease. Thanks to optical coherence tomography (OCT) technology and fluorescein angiography (FAG), significantly more macular edemas are detected. Macular edema can be found in various uveitis varieties and can show different clinical patterns. All macular edema should be treated. Macular edema with active inflammation usually reacts very well to general uveitis treatment...
June 9, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28573987/evaluating-ocular-blood-flow
#4
REVIEW
Jyotsna Maram, Sowmya Srinivas, Srinivas R Sadda
Studies have shown that vascular impairment plays an important role in the etiology and pathogenesis of various ocular diseases including glaucoma, age-related macular degeneration, diabetic retinopathy, and retinal venous occlusive disease. Thus, qualitative and quantitative assessment of ocular blood flow (BF) is a topic of interest for early disease detection, diagnosis, and management. Owing to the rapid improvement in technology, there are several invasive and noninvasive techniques available for evaluating ocular BF, with each of these techniques having their own limitations and advantages...
May 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28557829/progressive-decrease-of-peripapillary-angioflow-vessel-density-during-structural-and-visual-field-progression-in-early-primary-open-angle-glaucoma
#5
Gábor Holló
PURPOSE: To present a case of early primary open-angle glaucoma in which retinal nerve fiber layer thickness (RNFLT), ganglion cell complex (GCC), and visual field progression were accompanied with significant progression of peripapillary angioflow vessel density (PAFD) measured with optical coherence tomographic angiography. METHODS: A 68-year-old female patient who was under topical intraocular pressure (IOP) lowering medication for 20 years for ocular hypertension of the right and preperimetric primary open-angle glaucoma of the left eye (with reproducible inferotemporal and superotemporal neuroretinal rim and RNFL loss) was prospectively imaged with the AngioVue OCT for RNFLT, GCC thickness, and PAFD, and investigated with the Octopus Normal G2 visual field test on the same days at 6-month intervals for 18 months, while the IOP of the left eye escaped from control...
May 26, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28524137/-macular-blood-flow-in-glaucoma
#6
N I Kurysheva, E V Maslova, A V Trubilina, T D Ardzhevnishvili, A V Fomin
AIM: to assess macular blood flow in primary open-angle glaucoma (POAG) patients using optical coherence tomography angiography (OCT-A). MATERIAL AND METHODS: The study included 65 POAG patients and 22 age-matched healthy volunteers. Using OCT-A, blood flow parameters (Flow Area, Flow Index, and Vessel Density) were assessed in the para- and perifovea (0.6-2.5 mm and 2.5-5.5 mm, respectively) at the level of both superficial and deep vascular pexuses. Statistical analysis was performed with SPSS version 21 and MASS library of the R language...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28432111/regional-vascular-density-visual-field-sensitivity-relationship-in-glaucoma-according-to-disease-severity
#7
Joong Won Shin, Jiyun Lee, Junki Kwon, Jaewan Choi, Michael S Kook
AIMS: To study whether there are global and regional relationships between peripapillary vascular density (pVD) assessed by optical coherence tomography angiography (OCT-A) and visual field (VF) mean sensitivity at different glaucoma stages. METHODS: Microvascular images and peripapillary retinal nerve fibre layer (pRNFL) thicknesses were obtained using a Cirrus OCT-A device in 91 glaucoma subjects. The pVD was measured at various spatial locations according to the Garway-Heath map, using a MATLAB software (The MathWorks, Natick, Massachusetts)...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28376554/-retinal-vein-occlusion-which-treatment-when
#8
A Bajor, A Pielen, L Danzmann
According to the latest findings, macular oedema due to retinal vein occlusion is best treated safely and effectively with near-term intravitreal anti-VEGF therapy (aflibercept, bevacizumab [off label], ranibizumab). After an initial upload of 3 monthly injections of anti-VEGF, the decision on re-injection should be based on OCT (rather than on visual acuity). After initial monthly injections, the "pro-re-nata" (PRN) and the "treat-and-extend" regimens have been predominantly used in the further course of therapy...
April 4, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28348629/optical-coherence-angiographic-demonstration-of-retinal-changes-from-chronic-optic-neuropathies
#9
John J Chen, Jackson E AbouChehade, Raymond Iezzi, Jacqueline A Leavitt, Randy H Kardon
Glaucoma causes a decrease in peripapillary perfused capillary density on optical coherence tomography (OCT) angiography. However, other chronic optic neuropathies have not been explored with OCT angiography to see if these changes were specific to glaucoma. The authors evaluated OCT angiography in 10 patients who suffered various kinds of chronic optic neuropathies, including optic neuritis and ischaemic optic neuropathy, and found that all optic neuropathies showed a decrease in peripapillary vessel density on OCT angiography, regardless of the aetiology of the optic neuropathy...
April 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28297027/underlying-microstructure-of-parapapillary-deep-layer-capillary-dropout-identified-by-optical-coherence-tomography-angiography
#10
Eun Ji Lee, Tae-Woo Kim, Seung Hyen Lee, Jung-Ah Kim
Purpose: To characterize the microstructure underlying the parapapillary deep-layer microvasculature dropout (MvD) identified by optical coherence tomography (OCT) angiography (OCTA) in eyes with primary open-angle glaucoma (POAG). Methods: Parapapillary MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in deep-layer en face images obtained using swept-source OCTA. The peripapillary microstructure was characterized in 188 POAG patients with MvD in the parapapillary deep layer...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28288185/a-comparison-of-the-diagnostic-ability-of-vessel-density-and-structural-measurements-of-optical-coherence-tomography-in-primary-open-angle-glaucoma
#11
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To compare the diagnostic abilities of vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary open angle glaucoma (POAG) with that of the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements. METHODS: In a cross sectional study, 78 eyes of 50 control subjects and 117 eyes of 67 POAG patients underwent vessel density and structural measurements with spectral domain OCT...
2017: PloS One
https://www.readbyqxmd.com/read/28282698/-oct-angiography-of-the-glaucoma-optic-nerve
#12
C Lommatzsch, J M Koch, H Claußnitzer, C Heinz
Background Glaucoma is a major cause of blindness worldwide. One possible pathophysiological cause may be vascular dysregulation. Our aim was to investigate whether OCT angiography (OCTA) can detect modified flow density in glaucoma patients in the area of the optic disc. Methods A total of 68 eyes were examined by the OCTA system AngioVue™, including 34 eyes diagnosed with glaucoma and 34 healthy control eyes. Total peripapillary flow density was measured at two different levels of segmentation and also in each optic disc sector...
March 10, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28260359/-study-of-retinal-microvascular-perfusion-alteration-and-structural-damage-at-macular-region-in-primary-open-angle-glaucoma-patients
#13
H Xu, X M Kong
Objective: To investigate the alteration of retinal microcirculation and structural damage at macular region and evaluate their associations in primary open angle glaucoma (POAG) eyes. Methods: Cross-sectional study. Fifty-nine POAG patients (male/femal=35/24) were recruited from July 2015 to December 2015 in Eye, Ear, Nose and Throat Hospital of Fudan University. Twenty-eight eyes of early-stage POAG group (EG), 11 eyes of moderate-stage POAG group (MG) and 20 eyes of severe-stage POAG group (SG) were enrolled in this study...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28254626/vessel-density-and-structural-measurements-of-optical-coherence-tomography-in-primary-angle-closure-and-primary-angle-closure-glaucoma
#14
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll Ab Webers
PURPOSE: To evaluate the vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary angle closure (PAC) and primary angle closure glaucoma (PACG), and to compare their diagnostic abilities with the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements on OCT in PACG. DESIGN: Cross-sectional study METHODS: Seventy-seven eyes of 50 control subjects, 65 eyes of 45 patients with PACG, and 31 eyes of 22 PAC patients with a history of high IOP, underwent imaging with OCT...
February 27, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28237425/aqueous-angiography-in-living-nonhuman-primates-shows-segmental-pulsatile-and-dynamic-angiographic-aqueous-humor-outflow
#15
Alex S Huang, Meng Li, Diya Yang, Huaizhou Wang, Ningli Wang, Robert N Weinreb
PURPOSE: To evaluate the feasibility of safely performing aqueous angiography in intact eyes of living nonhuman primates (NHPs) for evaluating aqueous humor outflow and segmental patterns. DESIGN: Cross-sectional, observational study. SUBJECTS: Six nonhuman primates. METHODS: Aqueous angiography was performed in 6 nonhuman primates. After anesthesia, an anterior chamber (AC) maintainer was placed through a temporal 1-mm side-port wound...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28196732/peripapillary-and-macular-vessel-density-in-patients-with-glaucoma-and-single-hemifield-visual-field-defect
#16
Adeleh Yarmohammadi, Linda M Zangwill, Alberto Diniz-Filho, Luke J Saunders, Min Hee Suh, Zhichao Wu, Patricia Isabel C Manalastas, Tadamichi Akagi, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To compare hemifield differences in the vessel density of the peripapillary and macula in open-angle glaucoma eyes with visual field (VF) defect confined to one hemifield using optical coherence tomography angiography (OCT-A). DESIGN: Cross-sectional study. PARTICIPANTS: A total of 58 eyes of 58 patients with glaucoma with VF loss confined to a single hemifield and 28 healthy eyes. METHODS: Retinal vasculature information was summarized as circumpapillary vessel density (cpVD) and perifoveal vessel density (pfVD)...
May 2017: Ophthalmology
https://www.readbyqxmd.com/read/28169920/relationship-between-oct-angiography-temporal-peripapillary-vessel-density-and-octopus-perimeter-paracentral-cluster-mean-defect
#17
Gábor Holló
PURPOSE OF THE STUDY: The purpose of the study was to investigate the relationship between optical coherence tomography angiography angioflow vessel-density (PAFD) measured in the retinal nerve fiber layer in the temporal peripapillary sector and the average of the spatially corresponding superior and inferior paracentral cluster mean defect values (mean paracentral MD) measured with Octopus perimetry. MATERIALS AND METHODS: Spaerman's correlation between temporal peripapillary PAFD acquired with the Angiovue OCT and mean paracentral MD measured with the Normal and tendency-oriented perimetry strategy of Octopus G2 perimetry, respectively, was determined on 1 eye of 13 healthy participants, 22 medically controlled ocular hypertensive, and 27 stable early to moderate glaucoma patients...
May 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28152070/retinal-vessel-density-from-optical-coherence-tomography-angiography-to-differentiate-early-glaucoma-pre-perimetric-glaucoma-and-normal-eyes
#18
Handan Akil, Alex S Huang, Brian A Francis, Sirinivas R Sadda, Vikas Chopra
PURPOSE: To evaluate optic nerve vascular density using swept source optical coherence tomography angiography (OCTA) in patients with early primary open angle glaucoma (POAG), pre-perimetric glaucoma and normal eyes. METHODS: This is a prospective, observational study including 56 eyes in total and divided into 3 groups; 20 eyes with mild POAG, 20 pre-perimetric glaucoma eyes, and 16 age-matched normal eyes as controls. The optic disc region was imaged by a 1050-nm-wavelength swept-source OCT system (DRI OCT Triton, TOPCON)...
2017: PloS One
https://www.readbyqxmd.com/read/28056057/flat-anterior-chamber-after-trabeculectomy-in-secondary-angle-closure-glaucoma-with-best1-gene-mutation-case-series
#19
Yimin Zhong, Xinxing Guo, Hui Xiao, Jingyi Luo, Chengguo Zuo, Xiaobo Huang, Jingjing Huang, Lan Mi, Qingjiong Zhang, Xing Liu
PURPOSE: Trabeculectomy has been regarded as a mainstay of initial treatment in eyes of angle closure glaucoma (ACG) with peripheral anterior synechia > 180° in the Chinese population while its efficacy in secondary ACG with BEST1 gene mutation remains unclear. We set out to investigate the treatment outcome of trabeculectomy for secondary ACG in a group of patients with autosomal recessive bestrophinopathy (ARB). METHODS: In this retrospective case series study, 8 secondary ACG patients with ARB and their 4 recruited family members underwent a thorough ophthalmic examination including best-corrected visual acuity, Goldmann applanation tonometry, gonioscopy, and fundus examinations...
2017: PloS One
https://www.readbyqxmd.com/read/27998452/-pay-attention-on-optical-coherence-tomography-evaluation-for-optic-nerve-diseases
#20
M Wang
Optical coherence tomography(OCT) had become the most important imaging technique in ophthalmology. OCT is able to segment the retinal nerve fiber layer and retinal ganglion cell layer accurately. Quantitative analysis can be performed for both layers. OCT is very important to evaluate the neuron and axon loss in optic nerve diseases diagnosis. Meanwhile, OCT has great value for differentiating glaucoma and macular diseases from optic nerve diseases. This review presented OCT application in optic nerve diseases diagnosis, differentiation diagnosis, the key points in use and the features of en face OCT and OCT angiography...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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