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Oct angiography glaucoma

Nicole K Scripsema, Patricia M Garcia, Richard D Bavier, Toco Y P Chui, Brian D Krawitz, Shelley Mo, Steven A Agemy, Luna Xu, Yijie B Lin, Joseph F Panarelli, Paul A Sidoti, James C Tsai, Richard B Rosen
Purpose: To compare perfused peripapillary capillary density in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal patients using optical coherence tomography angiography (OCT-A). Methods: A retrospective review of POAG, NTG, and normal patients imaged with OCT-A was performed. En face OCT angiograms identifying peripapillary vessels were obtained using a spectral-domain OCT system (Avanti RTVue-XR). A custom image analysis approach identified perfused peripapillary capillaries, quantified perfused capillary density (PCD), and generated color-coded PCD maps for 3...
July 1, 2016: Investigative Ophthalmology & Visual Science
Adeleh Yarmohammadi, Linda M Zangwill, Alberto Diniz-Filho, Min Hee Suh, Siamak Yousefi, Luke J Saunders, Akram Belghith, Patricia Isabel C Manalastas, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate the association between vessel density measurements using optical coherence tomography angiography (OCT-A) and severity of visual field loss in primary open-angle glaucoma. DESIGN: Observational, cross-sectional study. PARTICIPANTS: A total of 153 eyes from 31 healthy participants, 48 glaucoma suspects, and 74 glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study. METHODS: All eyes underwent imaging using OCT-A (Angiovue; Optovue, Fremont, CA), spectral-domain OCT (Avanti; Optovue), and standard automated perimetry (SAP)...
October 7, 2016: Ophthalmology
Pukhraj Rishi, Neha Raka, Ekta Rishi
BACKGROUND: To study potential ischemic effects of intravitreal Bevacizumab (IVB) on unaffected retina in treatment-naive eyes with macular edema secondary to branch retinal vein occlusion (BRVO) and contralateral eyes secondary to systemic absorption. METHODS AND FINDINGS: Prospective, interventional series included 27 treatment-naive eyes with BRVO and macular edema. EXCLUSION CRITERIA: Eyes with diabetic retinopathy, glaucoma, vasculitides, papilledema or systemic neurologic condition...
2016: PloS One
Yusuke Ichiyama, Takayuki Minamikawa, Yuichi Niwa, Masahito Ohji
PURPOSE: To investigate the microvasculature changes of retinal nerve fiber layer (RNFL) defects in glaucoma. DESIGN: The study design is a case report. PATIENTS AND METHODS: Four glaucomatous eyes were included in this observational cross-sectional study. The microvasculature changes of RNFL defects were examined using optical coherence tomography (OCT) angiography. RESULTS: Three eyes had apparent wedge-shaped capillary dropout on OCT angiography...
September 2, 2016: Journal of Glaucoma
Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Felipe A Medeiros, Alberto Diniz-Filho, Luke J Saunders, Siamak Yousefi, Robert N Weinreb
PURPOSE: To investigate whether vessel density assessed by optical coherence tomography angiography (OCT-A) is reduced in glaucomatous eyes with focal lamina cribrosa (LC) defects. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: A total of 82 patients with primary open-angle glaucoma (POAG) from the Diagnostic Innovations in Glaucoma Study (DIGS) with and without focal LC defects (41 eyes of 41 patients in each group) matched by severity of visual field (VF) damage...
August 31, 2016: Ophthalmology
Gábor Holló
BACKGROUND/PURPOSE: Optical coherence tomography (OCT) angiography is a new noninvasive method to measure peripapillary microcirculation in various retinal layers, separately. In this case series, we investigate whether large medical intraocular pressure (IOP) reduction (>50% of the untreated baseline value) to IOP≤18 mm Hg influences peripapillary angioflow density (PAFD, percentage of the analyzed retinal area) in the retinal nerve fiber layer in high pressure (IOP≥35 mm Hg) ocular hypertensive and glaucoma eyes...
August 26, 2016: Journal of Glaucoma
Zaid Mammo, Morgan Heisler, Chandrakumar Balaratnasingam, Sieun Lee, Dao-Yi Yu, Paul Mackenzie, Steven Schendel, Andrew Merkur, Andrew Kirker, David Albiani, Eduardo Navajas, Mirza Faisal Beg, William Morgan, Marinko V Sarunic
PURPOSE: To evaluate the quantitative characteristics of the radial peripapillary capillary (RPC) network in glaucoma, glaucoma suspect, and normal eyes using speckle variance optical coherence tomography angiography (OCT-A). To determine correlations between RPC density, nerve fiber layer (NFL) thickness, and visual field indices. DESIGN: Cross-sectional study. METHODS: OCT-A images of RPCs were acquired at a single institution using a custom-built 1060 nm system from 3 groups: unilateral glaucoma (10 eyes from 5 subjects), glaucoma suspects (6 eyes from 3 subjects), and normal control eyes (16 eyes from 9 normal subjects)...
October 2016: American Journal of Ophthalmology
Adeleh Yarmohammadi, Linda M Zangwill, Alberto Diniz-Filho, Min Hee Suh, Patricia Isabel Manalastas, Naeem Fatehee, Siamak Yousefi, Akram Belghith, Luke J Saunders, Felipe A Medeiros, David Huang, Robert N Weinreb
PURPOSE: The purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) retinal vasculature measurements in healthy, glaucoma suspect, and glaucoma patients. METHODS: Two hundred sixty-one eyes of 164 healthy, glaucoma suspect, and open-angle glaucoma (OAG) participants from the Diagnostic Innovations in Glaucoma Study with good quality OCT-A images were included. Retinal vasculature information was summarized as a vessel density map and as vessel density (%), which is the proportion of flowing vessel area over the total area evaluated...
July 1, 2016: Investigative Ophthalmology & Visual Science
Tadamichi Akagi, Yuto Iida, Hideo Nakanishi, Noriko Terada, Satoshi Morooka, Hiroshi Yamada, Tomoko Hasegawa, Satoshi Yokota, Munemitsu Yoshikawa, Nagahisa Yoshimura
PURPOSE: To investigate microcirculation of peripapillary retina and optic disc in eyes with primary open-angle glaucoma (POAG) and hemifield visual field (VF) defects. DESIGN: Prospective observational case series with normal comparison group. METHODS: Sixty eyes with POAG (41 with superior and 19 with inferior hemifield VF defects) and 21 normal eyes were included in this study. Optical coherence tomography (OCT) angiography was used to acquire 3 × 3-mm optic disc cubes, and circumpapillary retinal nerve fiber layer thickness was also measured using OCT...
August 2016: American Journal of Ophthalmology
Chieh-Li Chen, Karine D Bojikian, Divakar Gupta, Joanne C Wen, Qinqin Zhang, Chen Xin, Rei Kono, Raghu C Mudumbai, Murray A Johnstone, Philip P Chen, Ruikang K Wang
BACKGROUND: To investigate the differences of perfusion in the optic nerve head (ONH) between normal and glaucomatous eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. METHODS: One eye from each subject was scanned with a 68 kHz Cirrus 5000 HD-OCT-based OMAG prototype system centered at the ONH (Carl Zeiss Meditec Inc, Dublin, CA, USA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans...
April 2016: Quantitative Imaging in Medicine and Surgery
Karine D Bojikian, Chieh-Li Chen, Joanne C Wen, Qinqin Zhang, Chen Xin, Divakar Gupta, Raghu C Mudumbai, Murray A Johnstone, Ruikang K Wang, Philip P Chen
PURPOSE: To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. DESIGN: Cross-sectional, observational study. SUBJECTS: Twenty-eight normal, 30 POAG, and 31 NTG subjects. METHODS: One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA)...
2016: PloS One
Pierre-Maxime Lévêque, Pierre Zéboulon, Emmanuelle Brasnu, Christophe Baudouin, Antoine Labbé
Purpose. To detect changes in optic nerve head (ONH) vascularization in glaucoma patients using spectral-domain OCT angiography (OCT-A). Material and Method. Fifty glaucoma patients and 30 normal subjects were evaluated with OCT-A (AngioVue®, Optovue). The total ONH vessel density and temporal disc vessel density were measured. Clinical data, visual field (VF) parameters, and spectral-domain OCT evaluation (RNFL: retinal nerve fiber layer thickness, GCC: ganglion cell complex thickness, and rim area) were recorded for glaucoma patients...
2016: Journal of Ophthalmology
Gábor Holló
PURPOSE: Disturbed peripapillary microcirculation may have a role in the development of glaucoma. Recently, using noninvasive optical coherence tomography (OCT) angiography with the AngioVue OCT (Optovue Inc., -Fremont, CA, USA), reduced peripapillary vessel density was found in glaucoma. In this case series, we investigate the relationship between retinal nerve fiber layer (RNFL) damage and peripapillary angioflow density (PAFD, % of the analyzed retinal area) in the superotemporal (ST), inferotemporal (IT), and temporal (T) peripapillary sectors in normal, ocular hypertensive (OHT), and primary open-angle glaucoma eyes...
May 2016: European Journal of Ophthalmology
Aziz A Khanifar, Michael J Espiritu, Jane S Myung, Grant D Aaker, Audrey N Schuetz, Donald J D'Amico, R V Paul Chan
BACKGROUND: Various imaging modalities play a role in diagnosing parasitic infections of the eye. We describe the spectral domain optical coherence tomography (SD-OCT) findings of an intravitreal parasite with subsequent evaluation by light microscopy. FINDINGS: This is a case report of a 37-year-old Ecuadorian man who presented with uveitic glaucoma and a new floater in his left eye for 1 week's duration. Full ophthalmic examination revealed an intravitreal parasite...
December 2015: Journal of Ophthalmic Inflammation and Infection
Carsten Heinz, Katy Kogelboom, Arnd Heiligenhaus
PURPOSE: Secondary glaucoma is a common complication in patients with uveitis. Heidelberg Retina Tomography (HRT) and retinal nerve fiber layer (RNFL) thickness on optical coherence tomography (OCT) are widely used for examining optic nerve head changes. We evaluated these parameters in patients with uveitis and secondary glaucoma and with inflammatory papillary leakage on fluorescein angiography. METHODS: Prospective single-center analysis of patients with uveitis, evaluating the impact of optic disc leakage on objective optic disc imaging parameters...
February 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Jean-Claude Mwanza, Donald L Budenz
PURPOSE OF REVIEW: Optical coherence tomography (OCT) aids in the diagnosis and long-term monitoring of various ocular diseases, including glaucoma. Initially, the retinal nerve fiber layer was the only OCT structural parameter used in glaucoma. Subsequent research has resulted in more retinal and optic nerve head parameters. In addition, OCT is being investigated for its ability to assess ocular hemodynamics. This review summarizes these spectral domain-optical coherence tomography (SDOCT) parameters in the context of glaucoma...
March 2016: Current Opinion in Ophthalmology
Georges Azar, Romain Leze, Aude Affortit-Demoge, Céline Faure
Objectives. To demonstrate the usefulness of "en-face" Spectral Domain Optical Coherence Tomography (SD-OCT) combined with Fluorescein Angiography (FA) in the investigation of peripapillary intrachoroidal cavitation. Materials and Methods. A 72-year-old man followed for primary open-angle glaucoma (POAG) for 4 years was referred for an asymptomatic "peripapillary lesion." A full ophthalmological examination and conventional imaging of the retina were done. FA, Indocyanine Green Angiography (ICG-A), and SD-OCT using the "en-face" technique were also performed...
2015: Case Reports in Ophthalmological Medicine
Xiaolei Wang, Chunhui Jiang, Tony Ko, Xiangmei Kong, Xiaobo Yu, Wang Min, Guohua Shi, Xinghuai Sun
PURPOSE: To explore how optic disc perfusion varies in patients with open-angle glaucoma (OAG) and how this correlates with glaucoma severity. METHODS: We performed a prospective and cross-sectional observational study that included 62 eyes from 62 patients with OAG, divided into three groups according to their visual field (VF) results, and 20 eyes from 20 normal control subjects. Optic disc perfusion was studied using optical coherence tomography angiography (angio-OCT), and flow index and vessel density were determined...
September 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
Liang Liu, Yali Jia, Hana L Takusagawa, Alex D Pechauer, Beth Edmunds, Lorinna Lombardi, Ellen Davis, John C Morrison, David Huang
IMPORTANCE: Vascular factors may have important roles in the pathophysiology of glaucoma. A practical method for the clinical evaluation of ocular perfusion is needed to improve glaucoma management. OBJECTIVE: To detect peripapillary retinal perfusion in glaucomatous eyes compared with normal eyes using optical coherence tomography (OCT) angiography. DESIGN, SETTING, AND PARTICIPANTS: Prospective observational study performed from July 24, 2013, to April 17, 2014...
September 2015: JAMA Ophthalmology
N Voide, F-X Borruat
BACKGROUND: Microcystic macular edema can occur after optic neuropathies of various etiologies, and is easily demonstrated by OCT. We report a cohort of patients with microcystic macular edema. PATIENTS AND METHODS: All patients with optic neuropathy and microcystic macular edema were enrolled. Demographics, visual function, retinal angiographies and OCT parameters were studied. RESULTS: Nineteen patients (23 eyes) exhibited microcystic macular edema: 10 men/9 women, aged 17-91 years...
April 2015: Klinische Monatsblätter Für Augenheilkunde
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