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REVIEW
Andrew D Pucker, Tsz Wing Yim, Erin Rueff, William Ngo, Anna A Tichenor, John E Conto
BACKGROUND: Meibomian gland dysfunction (MGD) is the most common underlying cause of dry eye disease (DED). MGD leads to pathological alteration of the composition or quantity of meibum, or both, which subsequently results in tear evaporation and the typical signs and symptoms associated with DED. The LipiFlow Thermal Pulsation System (LipiFlow) is a medical device used to treat MGD in office; however, it is unclear if LipiFlow can outperform other DED treatments. OBJECTIVES: To evaluate the effectiveness of LipiFlow for treating DED signs and symptoms and the safety of LipiFlow compared with sham or other available treatments for MGD in adults...
February 5, 2024: Cochrane Database of Systematic Reviews
#22
REVIEW
Colin A Morton, Rolf-Markus Szeimies, Lasse R Braathen
This article reviews the 2022 European Society for Photodynamic Therapy (Euro-PDT) Annual Congress. PDT has been investigated for the treatment of a broad number of oncologic, infectious and inflammatory indications. New studies confirm the potential for wider use of topical PDT for acne and photoaging, as well as several uncommon conditions including tinea capitis, Mycobacterium marinum, cutaneous alternariosis, resistant acral warts, eyelid Bowen's disease, mycosis fungoides, pseudolymphoma, and graft-versus-host disease...
October 1, 2023: European Journal of Dermatology: EJD
#23
JOURNAL ARTICLE
Darina Krastinova, Ghaleb A Al-Mekhlafi, Fatma M El-Badawy, Hossein M El-Badawy, Demetrio Germanò
Background The facial nerve plays a crucial role in innervating the motor supply of facial muscles, enabling essential facial expressions that facilitate human communication. Defects or damages to this nerve can have significant consequences, leading to functional, emotional, and social difficulties caused by the immobility of facial muscles. Patients suffering from irreversible facial nerve palsy often experience functional symptoms such as eyelid closure defects, mouth deviation, and limited movement. Methods This study aims to address these challenges and offer potential solutions for patients with irreversible facial nerve palsy...
December 2023: Curēus
#24
JOURNAL ARTICLE
Yousun Hwang, Smith Arayaskul, Vasanop Vachiramon, Kyu-Ho Yi
OBJECTIVE: To assess the subjective experiences of patients following monopolar radiofrequency (RF) treatment for facial rejuvenation and anti-aging purposes. METHODS: A study involving 50 female patients (aged 30-70 years, Fitzpatrick skin type III and IV) who received a single session of RF treatment. Exclusion criteria comprised active infections, skin diseases, pregnancy, or history of recent anti-aging treatments. Thirty-four patients completed a 10-question questionnaire after 3 months of treatment...
February 2024: Skin Research and Technology
#25
JOURNAL ARTICLE
Sandip K Basu, Amanda Prislovsky, Nataliya Lenchik, Daniel J Stephenson, Rajesh Agarwal, Charles E Chalfant, Nawajes Mandal
Vesicating chemicals like sulfur mustard (SM) or nitrogen mustard (NM) can cause devastating damage to the eyes, skin, and lungs. Eyes, being the most sensitive, have complicated pathologies that can manifest immediately after exposure (acute) and last for years (chronic). No FDA-approved drug is available to be used as medical counter measures (MCMs) against such injuries. Understanding the pathological mechanisms in acute and chronic response of the eye is essential for developing effective MCMs. Here, we report the clinical and histopathological characterization of a mouse model of NM-induced ocular surface injury (entire surface) developed by treating the eye with 2% ( w / v ) NM solution for 5 min...
January 6, 2024: International Journal of Molecular Sciences
#26
JOURNAL ARTICLE
R Hao, Y C Wang, T Y Zhang, Y Liu, R Niu, Z Yin, W Zhang
Objective: To investigate the clinical features, imaging manifestations, histopathological characteristics, and surgical outcomes in pediatric progressive restrictive strabismus. Methods: A retrospective case series study was conducted, including data from 9 cases (9 eyes) of pediatric progressive restrictive strabismus treated at Tianjin Eye Hospital from June 2017 to October 2022. The study compared the degree of globe protrusion in both eyes, changes in eyelid fissure height during internal and external rotation in the primary gaze, summarized clinical characteristics, and analyzed intraoperative conditions, surgical outcomes and postoperative histopathological results of strabismus correction surgery...
January 11, 2024: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
#27
JOURNAL ARTICLE
Zeynep Gokce-Samar, Annalisa Vetro, Julitta De Bellescize, Tiziana Pisano, Laloe Monteiro, Noémie Penaud, Christian M Korff, Joel Fluss, Carla Marini, Elisabetta Cesaroni, Blanca Mercedes Alvarez, Damien Sanlaville, Nicolas Chatron, Alexis A Arzimanoglou, Audrey Labalme, Vishnu A Cuddapah, Sarah M Ruggiero, Francois Lecoquierre, Gael Nicolas, Guerrot Anne Marie, Axel Lebas, Herve O Testard, Katherine L Helbig, Anna Ruiz, Adeline Ngoh, Manju A Kurian, Kimberley Reid, Robert Spaull, Pascal Joset, Georgia Ramantani, Katharina Steindl, Martin Krenn, Lucia Gerstl, Silvia Vieker, Dana Craiu, Manuela Pendziwiat, Chad Haldeman-Englert, Ilya Kanivets, Irina Romanova, Deepa S Rajan, Jill A Rosenfeld, Margaret Au, Katheryn Grand, John Graham, Arnaud Isapof, Nathalie Villeneuve, Thomas Smol, Roseline Caumes, Pia Zacher, Sonja Neuser, Sigrid Tinschert, Konrad Platzer, Tobias Bartolomaeus, Ines Mohnke, Maximilian Radtke, Rami Abou Jamra, Ingo Helbig, Floortje E Jansen, Klaas Koop, Gabrielle Rudolf, Sebastien Küry, Julien Courchet, Renzo Guerrini, Gaetan Lesca
BACKGROUND AND OBJECTIVES: Heterozygous variants in RAR-related orphan receptor B ( RORB ) have recently been associated with susceptibility to idiopathic generalized epilepsy. However, few reports have been published so far describing pathogenic variants of this gene in patients with epilepsy and intellectual disability (ID). In this study, we aimed to delineate the epilepsy phenotype associated with RORB pathogenic variants and to provide arguments in favor of the pathogenicity of variants...
January 23, 2024: Neurology
#28
JOURNAL ARTICLE
Xing Fan, Jie Long, Xin Quan, Yue Yin, Tong Li, Shuai Qiang, Bin Liu, Yang Li
BACKGROUND: Treatment for medial lower eyelid wrinkles is in great demand now. However, conventional injection of botulinum toxin A (BTX-A) often leads to serious complications. AIMS: We aim to evaluate the safety and efficacy of BTX-A injection with microneedle to treat medial lower eyelid wrinkles. METHODS: We collected clinical data of 16 patients to treat dynamic wrinkles on the medial aspect of the lower eyelid. Adverse effects at each stage of the treatment were recorded...
December 28, 2023: Journal of Cosmetic Dermatology
#29
JOURNAL ARTICLE
Martin Schicht, Jessica Farger, Saskia Wedel, Marco Sisignano, Klaus Scholich, Gerd Geisslinger, Natarajan Perumal, Franz H Grus, Swati Singh, Afsun Sahin, Friedrich Paulsen, Elke Lütjen-Drecoll
PURPOSE: Diabetes mellitus (DM) is a leading risk factor for corneal neuropathy and dry eye disease (DED). Another common consequence of DM is diabetic peripheral polyneuropathy (DPN). Both complications affect around 50 % of the DM patients but the relationship between DM, DED and DPN remains unclear. METHODS: In this study, we examined mice with early onset of DM and PN after streptozotocin (STZ)-induced diabetes (DPN). We compared the early morphological changes of the sciatic nerve, dorsal root and trigeminal ganglia with the changes in the ocular surface, including tear proteomic and we also investigated respective changes in the gene expressions and morphological alterations in the eye tissues involved in tear production...
December 21, 2023: Ocular Surface
#30
REVIEW
Francisco D Lucena-Neto, Luiz F M Falcão, Adolfo S Vieira-Junior, Evelly C S Moraes, Joacy P F David, Camilla C Silva, Jorge R Sousa, Maria I S Duarte, Pedro F C Vasconcelos, Juarez A S Quaresma
Monkeypox virus (MPXV), belonging to the Poxviridae family and Orthopoxvirus genus, is closely related to the smallpox virus. Initial prodromal symptoms typically include headache, fever, and lymphadenopathy. This review aims to detail various ocular manifestations and immune evasion associated with the monkeypox viral infection and its complications, making it appropriate as a narrative review. Common external ocular manifestations of MPXV typically involve a generalized pustular rash, keratitis, discharges, and dried secretions related to conjunctival pustules, photophobia, and lacrimation...
November 23, 2023: Viruses
#31
JOURNAL ARTICLE
Xi Peng, Ya-Li Du, Shu-Ting Liu, Hua Chen, Jia-Song Wang, Chao Wang, Hua-Tao Xie, Ming-Chang Zhang
PURPOSE: Hyperkeratinization of meibomian gland (MG) ducts is currently recognized as the primary pathologic mechanism of meibomian gland dysfunction (MGD). This research figured out a method to isolate the MG ducts and established a novel system to culture the human meibomian gland ductal cells (HMGDCs) for investigating the process of MGD. METHODS: The MG ducts were obtained from the eyelids of recently deceased donors and subjected to enzymatic digestion. The acini were then removed to isolate independent ducts...
December 1, 2023: Investigative Ophthalmology & Visual Science
#32
JOURNAL ARTICLE
Yan Wang, Yanqiu Liu, Jiping Cai, Tianyi Zong, Ziyin Zhang, Tianhua Xie, Tong Mu, Meili Wu, Qian Yang, Yangningzhi Wang, Xiaolu Wang, Yong Yao
BACKGROUND: Thyroid-associated orbitopathy (TAO) is a disease associated with autoimmune thyroid disorders and it can lead to proptosis, diplopia, and vision-threatening compressive optic neuropathy. To comprehensively understand the molecular mechanisms underlying orbital adipogenesis in TAO, we characterize the intrinsic molecular properties of orbital adipose/connective tissue from patients with TAO and control individuals. METHODS: RNA sequencing analysis (RNA-seq) was performed to measure the gene expression of orbital adipose/connective tissues of TAO patients...
2023: PeerJ
#33
José M Ceresetto, Romina A López, Andrés R Humphreys, Cristina Duboscq, Oscar M Rabinovich, Nicholas C Emery, Astrid Rausch, Luis Zapata Tapia, Pablo Dezanzo, Pablo Young
Plasminogen deficiency is a very rare multisystem entity that affects different tissues of the economy through the deposition of fibrin-rich pseudomembrane and determines a heterogeneous and diverse clinical presentation. It is transmitted in an autosomal recessive manner by mutations of the PLG gene on chromosome 6 and can be divided into hypoplasminogenemia or type I and dysplasminogenemia or type II, the latter not related to clinical pathology. Severe plasminogen deficiency has a prevalence of 1.6 individuals per million inhabitants and although it can be diagnosed in adulthood, the most severe symptoms are observed in infants and children...
2023: Medicina
#34
JOURNAL ARTICLE
Arnaud de la Fouchardiere, David J Papke, Daniel Pissaloux, Eleanor Russell-Goldman, Franck Tirode, Christopher D M Fletcher, John Hanna
Perivascular epithelioid cell neoplasms (PEComas) are tumors of uncertain cell lineage that show a strong female predominance. Their hallmark is the presence of combined smooth muscle and melanocytic differentiation. In most cases, melanocytic differentiation is detectable only by immunohistochemistry, but there are rare reports of PEComa with extensive melanin accumulation (so-called "melanotic PEComa"). Here we report a clinicopathologic series of 7 melanotic PEComas that occurred across a wide patient age range of 21 to 82 years (median: 41 y) and with a wide anatomic distribution, including 2 cases in the pelvis and 1 case each in the gallbladder, cervix, eyelid, epidural space, and femur...
January 1, 2024: American Journal of Surgical Pathology
#35
JOURNAL ARTICLE
Ke Yang, Ya Wen, Lei Zhu, Jia Yu Bao, Shang Li, Ying Hui Wang, Jun Feng, Lei Tian, Ying Jie
OBJECTIVE: To evaluate the effect of intense pulsed light (IPL) in the treatment of chronic hordeolum. METHODS: Patients with chronic hordeolum who underwent IPL treatment were enrolled in this study. According to the severity of hordeolum, the patients were treated with IPL 3 to 5 times. Patients' satisfaction and visual analog scale scores for ocular discomfort symptoms before and after treatment were collected. The number, congestion, long diameter, short diameter and area of nodules were also recorded and measured...
November 20, 2023: Biomedical and Environmental Sciences: BES
#36
JOURNAL ARTICLE
Shangbang Luo, Gagik P Djotyan, Rohan Joshi, Tibor Juhasz, Donald J Brown, James V Jester
PURPOSE: While changes in meibum quality are correlated with severity of meibomian gland dysfunction (MGD) and dry eye disease, little is known regarding the mechanics of meibum secretion. The purpose of this study was to develop a finite element model of meibum secretion and evaluate the effect of various factors that might impact meibum delivery to the ocular surface. METHODS: A finite element analysis in COMSOL 6.0 was used to simulate the flow of meibum within the gland's terminal excretory duct...
January 2024: Ocular Surface
#37
JOURNAL ARTICLE
Keigo Kosenda, Osamu Ichii, Yusuke Yamashita, Hiromichi Ohtsuka, Shigeo Fukuda, Yasuhiro Kon
The conjunctiva-associated lymphoid tissue (CALT) has been used as a target site for mucosal vaccinations in several animals. In this study, we compared the morphological features of CALT in the eyelid and third eyelid between Holstein calves and adult cows. In the eyelids, CALTs in the form of diffused lymphoid tissue (DLT) and lymphatic follicles (LF) were observed, where DLTs were dominant and LFs were scarce. The CALTs of cows comprised T-, B-cells, macrophages, and antigen-presenting cells (APCs). In particular, B-cells were dominant except in the eyelids of the calves...
November 11, 2023: Animals: An Open Access Journal From MDPI
#38
JOURNAL ARTICLE
Tara Samra, Tatiana Gomez-Gomez, Kinga Linowiecka, Aysun Akhundlu, Gabriella Lopez de Mendoza, Matthew Gompels, Wendy W Lee, Jennifer Gherardini, Jérémy Chéret, Ralf Paus
Human skin aging is associated with functional deterioration on multiple levels of physiology, necessitating the development of effective skin senotherapeutics. The well-tolerated neurohormone melatonin unfolds anti-aging properties in vitro and in vivo, but it remains unclear whether these effects translate to aged human skin ex vivo. We tested this in organ-cultured, full-thickness human eyelid skin (5-6 donors; 49-77 years) by adding melatonin to the culture medium, followed by the assessment of core aging biomarkers via quantitative immunohistochemistry...
November 4, 2023: International Journal of Molecular Sciences
#39
JOURNAL ARTICLE
J Li, Y C Wang, J Y Lin
Objective: To investigate the clinical pathological characteristics of ocular adnexal follicular lymphoma (OAFL). Methods: A retrospective case series study was conducted. Clinical data of 10 OAFL patients diagnosed at Tianjin Eye Hospital from January 1990 to May 2022 were collected. The study analyzed general patient information, medical history, site of involvement, imaging, histopathology, and molecular detection. Among them, 7 cases underwent Epstein-Barr virus-encoded small RNA (EBER) and B-cell lymphoma protein 2 (BCL-2)/immunoglobulin heavy chain gene (IgH) translocation gene detection...
November 11, 2023: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
#40
JOURNAL ARTICLE
Ahmet Demir, Ömer Faruk Ünverdi, Abdullah Erkan Orhan
OBJECTIVES: With the effect of advancing age and environmental factors, excess skin and muscle start to weigh on the eyelids and cause a tired facial expression. The prevailing opinion is that by partially excising muscle in surgical treatment, this load on the eyelid will be reduced, and more successful results will be obtained. Using a classic strip orbicularis oculi excision, the integrity of the muscle is disrupted, and morbidities such as lagophthalmos and edema increase. In this paper, we share our clinical experiences regarding the split excision of the palpebral part of the orbicularis oculi muscle and the subsequent process...
November 6, 2023: Journal of Craniofacial Surgery
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