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https://www.readbyqxmd.com/read/28221295/dynamic-intraductal-meibomian-probing-a-modified-approach-to-the-treatment-of-obstructive-meibomian-gland-dysfunction
#1
Zeba A Syed, Francis C Sutula
PURPOSE: Obstructive meibomian gland dysfunction is a leading cause of ocular morbidity and its treatment remains a challenge. Meibomian gland probing was initially described in 2010. Here, the authors describe a modified technique, dynamic intraductal meibomian probing, which offers several advantages over the traditional approach including increased magnification, greater eyelid stabilization, enhanced anesthesia, and easier identification of gland orifices through the expression of meibum...
February 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28119291/mirna-200c-and-mirna-141-as-potential-prognostic-biomarkers-and-regulators-of-epithelial-mesenchymal-transition-in-eyelid-sebaceous-gland-carcinoma
#2
Mansi Bhardwaj, Seema Sen, Kunzang Chosdol, Anjana Sharma, Neelam Pushker, Seema Kashyap, Sameer Bakhshi, Mandeep S Bajaj
BACKGROUND: MicroRNA (miRNA)-200c and miRNA-141 are tumour suppressors, which regulate epithelial-mesenchymal transition (EMT), leading to tumour invasion and metastasis in various malignancies. miRNA-200c and miRNA-141 maintain the epithelial phenotype by post-transcriptionally inhibiting the E-cadherin repressors, zinc finger E-box binding homeobox (ZEB)1 and ZEB2. The present study was performed to determine the prognostic significance of miRNA-200c and miRNA-141, and their association with EMT markers ZEB1, ZEB2 and E-cadherin in eyelid sebaceous gland carcinoma (SGC)...
January 24, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28046280/su-g-201-12-investigation-of-beta-emitter-90sr-90y-dose-distribution-using-gafchromic-ebt3-film-for-application-on-conformal-skin-brachytherapy-device
#3
C Ferreira, D Johnson, K Rasmussen, S Ahmad, J Jung
PURPOSE: To investigate (90) Sr-(90) Y as a high dose rate (HDR) source for application in a conformal skin brachytherapy (CSBT) device. The CSBT device has been previously developed to provide patient specific treatment for small inoperable lesions and irregular surfaces. METHODS: A popular beta emitter, (90) Sr-(90) Y was tested for feasibility in a CSBT device. A 1 cm diameter plaque was used to deliver dose to a solid water phantom containing EBT3 Gafchromic films arranged at the surface and perpendicular to it...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28005824/anthropometrically-based-surgical-technique-for-tessier-3-cleft-reconstruction
#4
Aaron L Morgan, Roger Cason, Christian A El Amm
Craniofacial clefts are rare entities, with an incidence reported as 1.43 to 4.85 per 100,000 births. The Tessier number 3 cleft, the most medial of the oblique clefts, can manifest as clefting of the lip between the canine and lateral incisors, colobomas of the nasal ala and lower eyelid, and inferior displacement of the medial canthus-frequently disrupting the lacrimal system with extreme variability in expressivity (Eppley).Literature on cleft lip repair is extensive and has evolved to incorporate anthropometric techniques, based on identifiable landmarks and anthropometric measurements that are compared with contralateral unaffected anatomy or population means and tracked over time to assess impact on growth...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27994815/pleomorphic-adenoma-of-the-eyelid-with-apocrine-gland-origin-an-atypical-location
#5
Renata T Rothwell, Sofia B Campelos, Sandra Prazeres
PURPOSE: To describe the clinical presentation and treatment of a patient with a cutaneous pleomorphic adenoma of the eyelid. CASE REPORT: A 73-year-old male patient presented with a nodular mass on the lateral third of his right upper eyelid, which had slowly enlarged over 10 years. Radiologic features were of an extra-conical mass, with no invasion of adjacent structures. An excisional biopsy of the lesion was performed. The histopathological examination revealed a biphasic tumor, composed of tubules with a double layer of epithelial cells arranged in a chondromyxoid stroma...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27942990/extratarsal-presentation-of-chalazion
#6
Moohwan Chang, Jiwoong Park, Sungeun E Kyung
PURPOSE: We report a case of atypical, extratarsal chalazion referred with a history of a chronic inflammatory mass found on the edge of the lower eyelid. METHODS: A 3-year-old female developed a small mass on the medial side of the right lower lid in 4-month duration. She was seen by her ophthalmologist and the diagnosis of a chalazion was made. Over the ensuing one month with warm compression, the lesion subsided and the new lesion appeared away from the edge on the lateral eyelid 3 months ago...
December 9, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27910822/prolonged-in-vitro-precultivation-alleviates-post-implantation-inflammation-and-promotes-stable-subcutaneous-cartilage-formation-in-a-goat-model
#7
Yi Liu, Dan Li, Zongqi Yin, Xusong Luo, Wei Liu, Wenjie Zhang, Zhiyong Zhang, Yilin Cao, Yu Liu, Guangdong Zhou
Synthetic biodegradable scaffolds such as polylactic acid coated polyglycolic acid (PLA-PGA) are especially suitable for engineering shaped cartilage such as auricle, but they induce a serious inflammatory reaction particularly in the immunologically aggressive subcutaneous site, leading to resorption of the engineered autologous cartilage. Our previous study in a rabbit model has demonstrated 2 weeks of in vitro precultivation could significantly alleviate the post-implantation inflammation induced by PLA-PGA engineered cartilaginous grafts, but reproduction of this result failed in a preclinical goat model...
December 2, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27891474/an-evaluation-of-use-of-botulinum-toxin-type-a-in-the-management-of-dynamic-forehead-wrinkles-a-clinical-study
#8
Avvaru Susmita, Naga Neelima Devi Kolli, Sridhar Meka, Srinivas Pandi Chakravarthi, Vivekanand Sabanna Kattimani, Krishna Prasad Lingamaneni, Latheef Saheb Shaik
INTRODUCTION: The pursuit of youth and beauty has undergone a resurgence of interest which is evidenced by increasing cosmetic procedures. Botulinum Toxin Type A (Botox) is one among the many procedures invented for facial rejuvenation which denervates certain muscles of facial expression responsible for facial wrinkles. It has been applied in the forehead, glabella, lateral canthal area and neck. In maxillofacial area hyperactive forehead wrinkles show sagging. AIM: This study was aimed to clinically evaluate the efficacy of Botox injection in the elimination of hyperdynamic forehead wrinkles and the objectives were to compare pre-operative and post-operative improvement in the number of wrinkles, photographic grading and patient satisfaction responses after 1(st) week, 4(th) week and 16(th) week...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27878850/analysis-of-morphological-changes-after-facial-massage-by-a-novel-approach-using-three-dimensional-computed-tomography
#9
H Nishimura, I Okuda, N Kunizawa, T Inoue, Y Nakajima, S Amano
BACKGROUND/PURPOSE: Photograph-based visual scoring has been used for evaluation of facial morphological changes. Here, we describe a three-dimensional computed tomography (3D-CT) method for objective analysis of facial and intra-facial (subcutaneous) changes. The effects of facial massage were examined using both methods. METHODS: Subjects were 12 healthy female volunteers without facial scars or deformation (age 30-54 years, mean 39.4 years). Photograph-based scoring of massage-induced morphological changes was done at the nasolabial folds, upper, lower and lateral cheeks and lower eyelids...
November 22, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27855196/age-related-changes-in-the-regenerative-potential-of-adipose-derived-stem-cells-isolated-from-the-prominent-fat-pads-in-human-lower-eyelids
#10
Xinhai Ye, Caihe Liao, Guangpeng Liu, Yipin Xu, Jian Tan, Zhenshun Song
The existence of multipotent adipose-derived stem cells isolated from human orbital fat (OF) tissue has shown great therapeutic potential in tissue engineering and regenerative medicine. But the use of stem cells for therapeutic applications is influenced by their proliferative and differentiation potentials, which may be affected by the age of the donor. So far there is little knowledge about the effects of donor age on the biological properties of human orbital adipose-derived stem cells (OASCs). The intraorbital fat protrusion in the lower eyelids occurs as an aging process, and the protruded fat is routinely removed during aesthetic surgeries...
2016: PloS One
https://www.readbyqxmd.com/read/27829784/irbp-deficiency-permits-precocious-ocular-development-and-myopia
#11
Shanu Markand, Natecia L Baskin, Ranjay Chakraborty, Erica Landis, Sara A Wetzstein, Kevin J Donaldson, Priyanka Priyadarshani, Shannon E Alderson, Curran S Sidhu, Jeffrey H Boatright, P Michael Iuvone, Machelle T Pardue, John M Nickerson
PURPOSE: Interphotoreceptor retinoid-binding protein (IRBP) is abundant in the subretinal space and binds retinoids and lipophilic molecules. The expression of IRBP begins precociously early in mouse eye development. IRBP-deficient (KO) mice show less cell death in the inner retinal layers of the retina before eyelid opening compared to wild-type C57BL/6J (WT) controls and eventually develop profound myopia. Thus, IRBP may play a role in eye development before visually-driven phenomena...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27828631/expression-of-heparanase-in-basal-cell-carcinoma-and-squamous-cell-carcinoma
#12
Maria Aparecida Silva Pinhal, Maria Carolina Leal Almeida, Alessandra Scorse Costa, Thérèse Rachell Theodoro, Rodrigo Lorenzetti Serrano, Carlos D'Apparecida Santos Machado
Background: Heparanase is an enzyme that cleaves heparan sulfate chains. Oligosaccharides generated by heparanase induce tumor progression. Basal cell carcinoma and squamous cell carcinoma comprise types of nonmelanoma skin cancer. Objectives: Evaluate the glycosaminoglycans profile and expression of heparanase in two human cell lines established in culture, immortalized skin keratinocyte (HaCaT) and squamous cell carcinoma (A431) and also investigate the expression of heparanase in basal cell carcinoma, squamous cell carcinoma and eyelid skin of individuals not affected by the disease (control)...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27755407/anthropometrically-based-surgical-technique-for-tessier-3-cleft-reconstruction
#13
Aaron L Morgan, Roger Cason, Christian A El Amm
Craniofacial clefts are rare entities, with an incidence reported as 1.43 to 4.85 per 100,000 births. The Tessier number 3 cleft, the most medial of the oblique clefts, can manifest as clefting of the lip between the canine and lateral incisors, colobomas of the nasal ala and lower eyelid, and inferior displacement of the medial canthus-frequently disrupting the lacrimal system with extreme variability in expressivity (Eppley).Literature on cleft lip repair is extensive and has evolved to incorporate anthropometric techniques, based on identifiable landmarks and anthropometric measurements that are compared with contralateral unaffected anatomy or population means and tracked over time to assess impact on growth...
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27755193/reversibility-of-gland-dropout-and-significance-of-eyelid-hygiene-treatment-in-meibomian-gland-dysfunction
#14
Yue Yin, Lan Gong
PURPOSE: To observe reversibility of meibomian gland (MG) dropout and analyze correlated factors and to compare the treatment efficiency with and without eyelid hygiene in patients with meibomian gland dysfunction (MGD). METHODS: Consecutive 78 eyes of 78 MGD (stage 2-3) patients who finished follow-up examination after 1-month of treatment were recruited in this retrospective study. All patients were treated with artificial lubricant and eyelid hygiene. Related ocular surface evaluation and meibomian gland assessment were examined...
March 2017: Cornea
https://www.readbyqxmd.com/read/27750289/pemphigus-autoantibodies-induce-blistering-in-human-conjunctiva
#15
Franziska Vielmuth, Vera Rötzer, Eva Hartlieb, Christoph Hirneiß, Jens Waschke, Volker Spindler
Purpose: The autoimmune blistering skin disease pemphigus vulgaris (PV) is caused by autoantibodies against desmosomal adhesion molecules. Patients may suffer conjunctival involvement, yet the underlying mechanisms are largely unclear. We characterized human and murine conjunctiva with respect to the PV autoantigens, and evaluated the effects and mechanisms of PV autoantibodies applied to human conjunctiva ex vivo. Methods: We obtained human conjunctiva specimens from surgical explants and established a short-term culture model to study the alterations induced by antibody fractions of PV patients (PV-IgG)...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27749621/periocular-breast-carcinoma-metastases-predominant-origin-from-the-lobular-variant
#16
Frederick A Jakobiec, Anna M Stagner, Natalie Homer, Michael K Yoon
PURPOSE: To further define the histopathologic features of breast carcinoma conducive to orbital metastasis. METHODS: Ten new female patients with orbital or eyelid breast cancer metastases encountered between 2011 and 2016 had their medical records reviewed for determining their clinical characteristics. Microscopic glass slides from biopsies and immunohistochemical test results were also analyzed. Biomarkers studied included cytokeratin 7, nuclear estrogen and progesterone receptors, HER2, and E-cadherin...
October 5, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27732647/are-eyes-a-mirror-of-the-soul-what-eye-wrinkles-reveal-about-a-horse-s-emotional-state
#17
Sara Hintze, Samantha Smith, Antonia Patt, Iris Bachmann, Hanno Würbel
Finding valid indicators of emotional states is one of the biggest challenges in animal welfare science. Here, we investigated in horses whether variation in the expression of eye wrinkles caused by contraction of the inner eyebrow raiser reflects emotional valence. By confronting horses with positive and negative conditions, we aimed to induce positive and negative emotional states, hypothesising that positive emotions would reduce whereas negative emotions would increase eye wrinkle expression. Sixteen horses were individually exposed in a balanced order to two positive (grooming, food anticipation) and two negative conditions (food competition, waving a plastic bag)...
2016: PloS One
https://www.readbyqxmd.com/read/27706598/defective-eyelid-leading-edge-cell-migration-in-c57bl-6-corneal-opacity-mice-with-an-eye-open-at-birth-phenotype
#18
L C Wu, C Liu, M R Jiang, Y M Jiang, Q H Wang, Z Y Lu, S J Wang, W L Yang, Y X Shao
Development of the eyelid requires coordination of the cellular processes involved in proliferation, cell size alteration, migration, and cell death. C57BL/6J-corneal opacity (B6-Co) mice are mutant mice generated by the administration of N-ethyl-N-nitrosourea (100 mg/kg). They exhibit the eyelids open at birth phenotype, abnormal round cell shape from tightened F-actin bundles in leading edge keratinocytes at E16.5, and gradual corneal opacity with neovessels. The tip of the leading edge in B6-Co mice did not move forward, and demonstrated a sharp peak shape without obvious directionality...
August 26, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27680487/extranodal-natural-killer-t-cell-lymphoma-nasal-type-with-primary-manifestation-as-an-upper-eyelid-swelling
#19
Akiko Kanzaki, Yoko Funasaka, Munenaga Nakamizo, Ayaka Shima, Takeshi Ryotokuji, Kazuo Dan, Mika Terasaki, Yuichi Sugisaki, Yu Fukuda, Seiji Kawana, Hidehisa Saeki
Extranodal natural killer/T-cell lymphoma (ENK/TCL) is most often in the nose or the nasopharynx but can present elsewhere. We report a rare case of ENK/TCL that presented as swelling of an upper eyelid without ocular involvement. A 76-year-old man visited our hospital with a swollen lesion of the left upper eyelid which had appeared 2 months earlier. A biopsy of the upper eyelid revealed slight perivascular and periadnexal infiltration of mononuclear cells with dermal edema. Treatment with oral prednisolone at a dosage of 20 mg/day decreased the eyelid swelling...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/27671791/viable-ednra-y129f-mice-feature-human-mandibulofacial-dysostosis-with-alopecia-mfda-syndrome-due-to-the-homologue-mutation
#20
Sibylle Sabrautzki, Michael A Sandholzer, Bettina Lorenz-Depiereux, Robert Brommage, Gerhard Przemeck, Ingrid L Vargas Panesso, Alexandra Vernaleken, Lillian Garrett, Katharina Baron, Ali O Yildirim, Jan Rozman, Birgit Rathkolb, Christine Gau, Wolfgang Hans, Sabine M Hoelter, Susan Marschall, Claudia Stoeger, Lore Becker, Helmut Fuchs, Valerie Gailus-Durner, Martin Klingenspor, Thomas Klopstock, Christoph Lengger, Leuchtenberger Stefanie, Eckhard Wolf, Tim M Strom, Wolfgang Wurst, Martin Hrabě de Angelis
Animal models resembling human mutations are valuable tools to research the features of complex human craniofacial syndromes. This is the first report on a viable dominant mouse model carrying a non-synonymous sequence variation within the endothelin receptor type A gene (Ednra c.386A>T, p.Tyr129Phe) derived by an ENU mutagenesis program. The identical amino acid substitution was reported recently as disease causing in three individuals with the mandibulofacial dysostosis with alopecia (MFDA, OMIM 616367) syndrome...
December 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
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