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Eyelid expression

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https://www.readbyqxmd.com/read/29133634/immunohistochemical-expression-of-x-linked-inhibitor-of-apoptosis-in-eyelid-sebaceous-gland-carcinoma-predicts-a-worse-prognosis
#1
Perumal Jayaraj, Seema Sen, P S Dhanaraj, Romika Jhajhria, Shalu Singh, Vijay Kumar Singh
PURPOSE: Overexpression of the inhibitors of apoptosis proteins have been demonstrated in a variety and of solid tumors including melanomas and nonmelanomas skin cancers. X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of apoptosis which prevents apoptosis by inhibiting caspases 9, 7, and 3. The prognostic value of XIAP in sebaceous gland carcinoma (SGC) remains unexplored. METHODS: The immunohistochemical expression of XIAP was evaluated in 29 SGC cases...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29128682/randomized-double-masked-trial-of-eyelid-cleansing-treatments-for-blepharitis
#2
Justin Sung, Michael T M Wang, Sang H Lee, Isabella M Y Cheung, Salim Ismail, Trevor Sherwin, Jennifer P Craig
PURPOSE: To compare the efficacy of a dedicated eyelid cleanser and diluted baby shampoo in the management of blepharitis. METHODS: Forty-three participants with clinical blepharitis signs were enrolled in a prospective, randomized, double-masked, paired-eye trial. A dedicated eyelid cleanser (TheraTears(®) SteriLid(®)) was applied to the eyelids of one eye (randomized) and diluted baby shampoo (Johnson's(®) No More Tears(®)) to the fellow eye, twice daily for 4 weeks...
November 8, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29054722/the-eyelids-and-tear-film-in-contact-lens-discomfort
#3
Jaya Sowjanya Siddireddy, Ajay Kumar Vijay, Jacqueline Tan, Mark Willcox
PURPOSE: To investigate characteristics of the eyelid margins, meibomian glands and the tear film of contact lens wearers, and to determine whether these characteristics were related to symptoms of contact lens discomfort. METHODS: A cross sectional study was performed on thirty existing daily wear soft contact lens wearers (6 male; 24 female) with median age of 23 years (range 18-41). Eyelid signs and tear film characteristics were evaluated during a single visit and subjects completed the contact lens and dry eye questionnaire (CLDEQ-8) to evaluate ocular discomfort...
October 17, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29052604/effect-of-topical-loteprednol-etabonate-with-lid-hygiene-on-tear-cytokines-and-meibomian-gland-dysfunction-in-prosthetic-eye-wearers
#4
J S Ko, Y Seo, M K Chae, S Y Jang, J S Yoon
PurposeTo assess tear cytokine levels and clinical outcomes in meibomian gland dysfunction (MGD) in the blind eye of patients wearing an ocular prosthesis after 2 months of treatment with topical loteprednol etabonate and eyelid scrubs with warm compresses.Patients and methodsThis study included patients with MGD wearing a unilateral ocular prosthesis for more than 1 year. All patients topically received 0.5% loteprednol etabonate and were instructed to scrub their eyelids with warm compresses on the prosthetic eye for 2 months...
October 20, 2017: Eye
https://www.readbyqxmd.com/read/29016863/a-tubb6-mutation-is-associated-with-autosomal-dominant-non-progressive-congenital-facial-palsy-bilateral-ptosis-and-velopharyngeal-dysfunction
#5
Walid Fazeli, Peter Herkenrath, Barbara Stiller, Antje Neugebauer, Julia Fricke, Ruth Lang-Roth, Gudrun Nürnberg, Michaela Thoenes, Jutta Becker, Janine Altmüller, Alexander E Volk, Christian Kubisch, Raoul Heller
Congenital cranial dysinnervation disorders (CCDDs) comprise a heterogeneous spectrum of diseases characterized by congenital, non-progressive impairment of eye, eyelid and/or facial movements including Möbius syndrome, Duane retraction syndrome, congenital ptosis, and congenital fibrosis of the extraocular muscles. Over the last 20 years, several CCDDs have been identified as neurodevelopmental disorders that are caused by mutations of genes involved in brain and cranial nerve development, e.g. KIF21A and TUBB3 that each plays a pivotal role for microtubule function...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28943255/keratin-14-positive-precursor-cells-spawn-a-population-of-migratory-corneal-epithelia-that-maintain-tissue-mass-throughout-life
#6
Alexander Richardson, Erwin P Lobo, Naomi C Delic, Mary R Myerscough, J Guy Lyons, Denis Wakefield, Nick Di Girolamo
The dynamics of epithelial stem cells (SCs) that contribute to the formation and maintenance of the cornea are poorly understood. Here, we used K14CreER(T2)-Confetti (Confetti) mice, sophisticated imaging, and computational modeling to trace the origins and fate of these cells during embryogenesis and adult life. We show that keratin-14 (K14(+))-expressing progenitors are defined and widely distributed across the E16.5 cornea, after which they undergo cycles of proliferation and dispersal prior to eyelid opening...
October 10, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28926885/-evaluation-of-short-term-effect-of-intense-pulsed-light-combined-with-meibomian-gland-expression-in-the-treatment-of-meibomian-gland-dysfunction
#7
B Rong, P Tu, Y Tang, R X Liu, W J Song, X M Yan
Objective: To explore short-term effect of intense pulsed light (IPL) combined with meibomian gland expression in treating meibomian gland dysfunction (MGD). Methods: This study was a prospective, randomized, double-masked, controlled study. Forty-four MGD patients were enrolled in the study and received three consecutive IPL treatments with an interval of 4 weeks. One eye of each patient was randomly assigned as the study eye receiving the IPL therapy with an energy of 14-16 J/cm(2), and the fellow eye was as the control eye receiving a placebo therapy with 0 J/cm(2)...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28902011/meibomian-gland-dysfunction-associated-with-periocular-radiotherapy
#8
Young Jun Woo, JaeSang Ko, Yong Woo Ji, Tae-Im Kim, Jin Sook Yoon
PURPOSE: To investigate the influence of periocular radiotherapy on meibomian glands. METHODS: We evaluated 28 patients (40 eyes) who received radiotherapy (RT group) for conjunctival or orbital lymphoma and 30 age-matched control subjects (60 eyes). Subjects underwent slit-lamp examination of the eyelids, Schirmer test, meibography, and evaluation of tear film breakup time (TBUT), Ocular Surface Disease Index (OSDI) scores, meibomian glands evaluation (meiboscore, meibum expressibility, and lid margin abnormality scores), and tear film lipid layer thickness using an ocular surface interferometer...
December 2017: Cornea
https://www.readbyqxmd.com/read/28887117/analysis-of-cytokine-levels-in-tears-and-clinical-correlations-after-intense-pulsed-light-treating-meibomian-gland-dysfunction
#9
RANDOMIZED CONTROLLED TRIAL
Ruixing Liu, Bei Rong, Ping Tu, Yun Tang, Wenjing Song, Rolando Toyos, Melissa Toyos, Xiaoming Yan
PURPOSE: To investigate the change from baseline of inflammatory markers in tears of dry eye disease (DED) subjects owing to meibomian gland dysfunction (MGD) after intense pulsed light (IPL) treatment and meibomian gland expression (MGE) compared to sham treatment, and the correlations with ocular surface parameters. DESIGN: Randomized, double-masked, controlled study. METHODS: Those randomized into the active treatment arm received 3 consecutive treatments (14∼16 J/cm(2)) approximately 4 weeks apart in the periocular region...
November 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28812919/comparison-of-primary-and-secondary-enucleation-for-uveal-melanoma
#10
Chau M Pham, Philip L Custer, Steven M Couch
We investigated operative course and post-operative findings of patients undergoing primary enucleation for uveal melanoma versus those requiring secondary enucleation after brachytherapy. A retrospective chart review was performed with IRB approval on patients receiving treatment for uveal melanoma. Patients with enucleation as initial treatment and patients enucleated after plaque brachytherapy were analyzed for demographic data, operative course, and post-enucleation outcome. Further cause analysis for secondary enucleations was investigated...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28812417/lacrimal-gland-abscesses-case-series-and-literature-review
#11
Brian Savoie, Rand Rodgers, Matthew Gorski
Acute dacryoadenitis with abscess formation has been rarely described. We describe four cases that resolved with incision and drainage. This includes a retrospective case series of four patients with radiologically confirmed lacrimal gland abscesses and a review of the reported cases in the literature. Computed tomography showed characteristic rim enhancing collections with central attenuation in all four cases. All patients presented with ptosis, upper eyelid erythema, and severe pain similar to scleritis...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28724810/updates-on-upper-eyelid-blepharoplasty
#12
REVIEW
Kasturi Bhattacharjee, Diva Kant Misra, Nilutparna Deori
The human face is composed of small functional and cosmetic units, of which the eyes and periocular region constitute the main point of focus in routine face-to-face interactions. This dynamic region plays a pivotal role in the expression of mood, emotion, and character, thus making it the most relevant component of the facial esthetic and functional unit. Any change in the periocular unit leads to facial imbalance and functional disharmony, leading both the young and the elderly to seek consultation, thus making blepharoplasty the surgical procedure of choice for both cosmetic and functional amelioration...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28695824/a-multi-scale-model-for-hair-follicles-reveals-heterogeneous-domains-driving-rapid-spatiotemporal-hair-growth-patterning
#13
Qixuan Wang, Ji Won Oh, Hye-Lim Lee, Anukriti Dhar, Tao Peng, Raul Ramos, Christian Fernando Guerrero-Juarez, Xiaojie Wang, Ran Zhao, Xiaoling Cao, Jonathan Le, Melisa A Fuentes, Shelby C Jocoy, Antoni R Rossi, Brian Vu, Kim Pham, Xiaoyang Wang, Nanda Maya Mali, Jung Min Park, June-Hyug Choi, Hyunsu Lee, Julien M D Legrand, Eve Kandyba, Jung Chul Kim, Moonkyu Kim, John Foley, Zhengquan Yu, Krzysztof Kobielak, Bogi Andersen, Kiarash Khosrotehrani, Qing Nie, Maksim V Plikus
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns...
July 11, 2017: ELife
https://www.readbyqxmd.com/read/28610808/sarcoidosis-of-the-lacrimal-gland-as-a-first-manifestation
#14
M Y Peralta-Gómez, K A Ávila-Ocampo, S Huerta-Velázquez, M I Rivera-Salgado
OBJECTIVE/METHOD: The first manifestation of sarcoidosis is usually at the pulmonary level. The case is described of a 40-year-old female patient, who presented with an increased volume of the lacrimal gland and mechanical ptosis of upper left eyelid as the first expression of this disease. RESULT/CONCLUSION: The diagnosis of systemic sarcoidosis with primary presentation of the lacrimal gland was made after performing several immunological studies with negative results, imaging studies, and taking of glandular and lymph node biopsies...
June 10, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28606618/hypoxic-postconditioning-attenuates-apoptosis-via-activation-of-adenosine-a2a-receptors-on-dermal-microvascular-endothelial-cells-of-human-flaps
#15
Jiankun Cao, Wenzhi Li, Chao Cui, Binbin Li, Yi Xin, Lun Cai, Zhizhong Gong, Huang Lin
BACKGROUND: In recent years, many studies have demonstrated that endogenous adenosine induced by ischemia postconditioning reduces apoptosis in various models, but no study has clearly elucidated the effects of hypoxic postconditioning (HPC) in human dermal microvascular endothelial cells (HDMECs) of flaps, and the subtype of adenosine receptors involved remains unknown. In our study, we sought to identify the role of adenosine A2a receptor in the antiapoptotic effects of HPC. MATERIALS AND METHODS: The HDMECs were isolated from human upper eyelid tissue...
September 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28593054/meibomian-gland-dysfunction-in-type-2-diabetic-patients
#16
Xiaolei Lin, Binbin Xu, Yuxi Zheng, Terry G Coursey, Yinying Zhao, Junhua Li, Yana Fu, Xuewen Chen, Yun-E Zhao
PURPOSE: To investigate meibomian gland and tear film function in patients with type 2 diabetes. METHODS: This prospective study compared changes in meibomian gland and tear film function in type 2 diabetic patients with nondiabetic patients. Meibomian gland function was evaluated by measuring lipid layer thickness (LLT), grading of meibomian gland loss, lid margin abnormalities, and expression of meibum. Tear film function was assessed by measuring tear breakup time (TBUT), the Schirmer I test, noninvasive breakup time (NIBUT), tear meniscus height (TMH), and corneal fluorescein staining...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28587435/effect-of-topical-rebamipide-on-goblet-cells-in-the-lid-wiper-of-human-conjunctiva
#17
Satoru Kase, Toshiya Shinohara, Manabu Kase, Susumu Ishida
It has been demonstrated that topical administration of rebamipide, which is an antiulcer agent, increases the mucin level of the tear film and ameliorates ocular surface conditions such as lid wiper epitheliopathy. The aim of the present study was to analyze the changes in goblet cell number, cell proliferation, and epidermal growth factor receptor (EGFR) induced by topical rebamipide addition to the lid wiper of humans. A total of 30 eyelid tissue samples were obtained during involutional entropion surgeries, fixed in paraformaldehyde, embedded in paraffin and divided into two groups: Rebamipide or non-rebamipide...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28585267/intense-pulsed-light-treatment-and-meibomian-gland-expression-for-moderate-to-advanced-meibomian-gland-dysfunction
#18
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of periocular intense pulsed light therapy combined with meibomian gland expression for chronic dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This single-institution, open-label prospective study involved 26 participants who received bilateral treatments using a proprietary intense pulsed light device (E > Eye, E-Swin, Paris, France) combined with therapeutic meibomian gland expression at baseline, Week 2 and Week 6...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28585260/randomised-controlled-trial-of-topical-antibacterial-manuka-leptospermum-species-honey-for-evaporative-dry-eye-due-to-meibomian-gland-dysfunction
#19
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of standardised Manuka (Leptospermum species) antibacterial honey as adjunctive twice daily treatment to conventional therapy (warm compresses, lid massage and preservative-free lubricant), in participants with evaporative dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This prospective, open-label study involved 114 participants. After two weeks of conventional therapy participants were randomised to one of three treatment groups: Optimel Antibacterial Manuka Eye Gel (98 per cent Leptospermum species honey) plus conventional therapy (n = 37), Optimel Manuka plus Lubricant Eye Drops (16 per cent Leptospermum species honey) plus conventional therapy (n = 37) and a control (conventional therapy) (n = 40)...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28576205/incision-sparing-management-of-canaliculitis-an-efficacious-alternative-to-surgical-management
#20
David Zhiwei Law, E-Shawn Goh
OBJECTIVE: The aim of this study was to describe the outcomes of conservative (punctal dilation, manual expression, microcurettage, and canalicular irrigation with antibiotics) and surgical (punctoplasty) modalities for the management of canaliculitis in an Asian population. METHODS: The medical records of 11 consecutive patients (12 eyes) presenting with canaliculitis to one surgeon from August 2010 to January 2014 were reviewed. The clinical presentation, findings, management, microbiology, and treatment outcomes were studied...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
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