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https://www.readbyqxmd.com/read/27829452/genetic-impairment-of-parasite-myosin-motors-uncovers-the-contribution-of-host-cell-membrane-dynamics-to-toxoplasma-invasion-forces
#1
Marion Bichet, Bastien Touquet, Virginie Gonzalez, Isabelle Florent, Markus Meissner, Isabelle Tardieux
BACKGROUND: The several-micrometer-sized Toxoplasma gondii protozoan parasite invades virtually any type of nucleated cell from a warm-blooded animal within seconds. Toxoplasma initiates the formation of a tight ring-like junction bridging its apical pole with the host cell membrane. The parasite then actively moves through the junction into a host cell plasma membrane invagination that delineates a nascent vacuole. Recent high resolution imaging and kinematics analysis showed that the host cell cortical actin dynamics occurs at the site of entry while gene silencing approaches allowed motor-deficient parasites to be generated, and suggested that the host cell could contribute energetically to invasion...
November 9, 2016: BMC Biology
https://www.readbyqxmd.com/read/27739803/high-pressure-structural-changes-in-liquid-silica
#2
A Denoeud, S Mazevet, F Guyot, F Dorchies, J Gaudin, A Ravasio, E Brambrink, A Benuzzi-Mounaix
The structural properties of liquid silica at high pressure and moderate temperature conditions, also referred to as the warm dense matter regime, were investigated using time-resolved K-edge x-ray absorption spectroscopy and ab initio calculations. We used a nanosecond laser beam to compress uniformly a solid SiO_{2} target and a picosecond laser beam to generate a broadband x-ray source. We obtained x-ray absorption spectra at the Si K edge over a large pressure-temperature domain to probe the liquid phase up to 3...
September 2016: Physical Review. E
https://www.readbyqxmd.com/read/27711116/pressure-infusion-cuff-and-blood-warmer-during-massive-transfusion-an-experimental-study-about-hemolysis-and-hypothermia
#3
Thomas G Poder, Denise Pruneau, Josée Dorval, Louis Thibault, Jean-François Fisette, Suzanne K Bédard, Annie Jacques, Patrice Beauregard
BACKGROUND: Blood warmers were developed to reduce the risk of hypothermia associated with the infusion of cold blood products. During massive transfusion, these devices are used with compression sleeve, which induce a major stress to red blood cells. In this setting, the combination of blood warmer and compression sleeve could generate hemolysis and harm the patient. We conducted this study to compare the impact of different pressure rates on the hemolysis of packed red blood cells and on the outlet temperature when a blood warmer set at 41...
2016: PloS One
https://www.readbyqxmd.com/read/27627404/dissociation-along-the-principal-hugoniot-of-the-laser-m%C3%A3-gajoule-ablator-material
#4
P Colin-Lalu, V Recoules, G Salin, T Plisson, E Brambrink, T Vinci, R Bolis, G Huser
Glow discharge polymer hydrocarbon (GDP-CH) is used as the ablator material in inertial confinement fusion (ICF) capsules for the Laser Mégajoule and National Ignition Facility. Due to its fabrication process, GDP-CH chemical composition and structure differ from commercially available plastics and detailed knowledge of its properties in the warm dense matter regime is needed to achieve accurate design of ICF capsules. First-principles ab initio simulations of the GDP-CH principal Hugoniot up to 8 Mbar were performed using the quantum molecular dynamics (QMD) code abinit and showed that atomic bond dissociation has an effect on the compressibility...
August 2016: Physical Review. E
https://www.readbyqxmd.com/read/27594570/-skillful-care-for-chronic-vascular-wounds
#5
C Goullet de Rugy, I Lazareth, C You, A Stansal, P Priollet
In vascular medicine, wound care requires pluridisciplinary expertise and nursing skill. Care must be perfectly adapted to each individual patient, the specificities of each particular wound, and the underlying vascular disease. The goal is to achieve wound healing. Inappropriate care can retard healing or even aggravate the wound. The skin should be cleaned with water a non-allergic detergent and should concern the entire limb in addition to the wound itself. Fibrin or necrosis detersion is an important step that can be painful...
September 2016: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/27573051/fish-ecology-and-evolution-in-the-world-s-oxygen-minimum-zones-and-implications-of-ocean-deoxygenation
#6
N D Gallo, L A Levin
Oxygen minimum zones (OMZs) and oxygen limited zones (OLZs) are important oceanographic features in the Pacific, Atlantic, and Indian Ocean, and are characterized by hypoxic conditions that are physiologically challenging for demersal fish. Thickness, depth of the upper boundary, minimum oxygen levels, local temperatures, and diurnal, seasonal, and interannual oxycline variability differ regionally, with the thickest and shallowest OMZs occurring in the subtropics and tropics. Although most fish are not hypoxia-tolerant, at least 77 demersal fish species from 16 orders have evolved physiological, behavioural, and morphological adaptations that allow them to live under the severely hypoxic, hypercapnic, and at times sulphidic conditions found in OMZs...
2016: Advances in Marine Biology
https://www.readbyqxmd.com/read/27562476/ice-vii-from-aqueous-salt-solutions-from-a-glass-to-a-crystal-with-broken-h-bonds
#7
S Klotz, K Komatsu, F Pietrucci, H Kagi, A-A Ludl, S Machida, T Hattori, A Sano-Furukawa, L E Bove
It has been known for decades that certain aqueous salt solutions of LiCl and LiBr readily form glasses when cooled to below ≈160 K. This fact has recently been exploited to produce a « salty » high-pressure ice form: When the glass is compressed at low temperatures to pressures higher than 4 GPa and subsequently warmed, it crystallizes into ice VII with the ionic species trapped inside the ice lattice. Here we report the extreme limit of salt incorporation into ice VII, using high pressure neutron diffraction and molecular dynamics simulations...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27555745/the-sustained-effect-12-months-of-a-single-dose-vectored-thermal-pulsation-procedure-for-meibomian-gland-dysfunction-and-evaporative-dry-eye
#8
Caroline A Blackie, Christy A Coleman, Edward J Holland
PURPOSE: To evaluate the sustained effect (up to 1 year) of a single, 12-minute vectored thermal pulsation (VTP) treatment in improving meibomian gland function and dry eye symptoms in patients with meibomian gland dysfunction and evaporative dry eye. METHODS: The prospective, multicenter, open-label clinical trial included 200 subjects (400 eyes) who were randomized to a single VTP treatment (treatment group) or twice-daily, 3-month, conventional warm compress and eyelid hygiene therapy (control group)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27552213/evaluation-of-the-effectiveness-of-compression-garments-on-autonomic-nervous-system-recovery-following-exercise
#9
Alessandro Piras, Giorgio Gatta
The aim of this investigation was to evaluate the recovery pattern of a whole body compression garment on hemodynamic parameters and on ANS activity following a swimming performance. Ten young male athletes were recruited and tested in two different days, with and without wearing the garment during the recovery phase. After a warm-up of 15 minutes, athletes were instructed to perform a maximal 400m freestyle swimming event, and then time series of beat-to-beat intervals for heart rate variability (HRV), baroreflex sensitivity (BRS), and hemodynamic parameters were recorded for 90 minutes of recovery...
August 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27509859/compression-and-ablation-of-the-photo-irradiated-molecular-cloud-the-orion-bar
#10
Javier R Goicoechea, Jérôme Pety, Sara Cuadrado, José Cernicharo, Edwige Chapillon, Asunción Fuente, Maryvonne Gerin, Christine Joblin, Nuria Marcelino, Paolo Pilleri
The Orion Bar is the archetypal edge-on molecular cloud surface illuminated by strong ultraviolet radiation from nearby massive stars. Our relative closeness to the Orion nebula (about 1,350 light years away from Earth) means that we can study the effects of stellar feedback on the parental cloud in detail. Visible-light observations of the Orion Bar show that the transition between the hot ionized gas and the warm neutral atomic gas (the ionization front) is spatially well separated from the transition between atomic and molecular gas (the dissociation front), by about 15 arcseconds or 6,200 astronomical units (one astronomical unit is the Earth-Sun distance)...
August 10, 2016: Nature
https://www.readbyqxmd.com/read/27500111/comparison-of-therapeutic-effects-of-topical-azithromycin-solution-and-systemic-doxycycline-on-posterior-blepharitis
#11
Mehdi Zandian, Neda Rahimian, Sanaz Soheilifar
AIM: To compare the effect of azithromycin drop and doxycycline capsule on treatment of posterior blepharitis. METHODS: Fifty patients (100 eyes) with moderate posterior blepharitis, randomly divided into two therapeutic groups; all the patients got warm eyelid compress and massage three times a day for 3wk. In addition the first group got azithromycin 1% drop, twice daily for 1wk and then one drop daily for 2wk. The second group got oral doxycycline 100 mg daily for 3wk...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27427325/supplemental-oxygen-during-high-intensity-exercise-training-in-nonhypoxemic-copd
#12
Daniel Neunhäuserer, Eva Steidle-Kloc, Gertraud Weiss, Bernhard Kaiser, David Niederseer, Sylvia Hartl, Marcus Tschentscher, Andreas Egger, Martin Schönfelder, Bernd Lamprecht, Michael Studnicka, Josef Niebauer
BACKGROUND: Physical exercise training is an evidence-based treatment in chronic obstructive pulmonary disease (COPD), and patients' peak work rate is associated with reduced COPD mortality. We assessed whether supplemental oxygen during exercise training in nonhypoxemic COPD patients might lead to superior training outcomes, including improved peak work rate. METHODS: This was a randomized, double-blind, controlled, crossover trial. Twenty-nine COPD patients (63...
July 14, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27246145/probing-local-and-electronic-structure-in-warm-dense-matter-single-pulse-synchrotron-x-ray-absorption-spectroscopy-on-shocked-fe
#13
Raffaella Torchio, Florent Occelli, Olivier Mathon, Arnaud Sollier, Emilien Lescoute, Laurent Videau, Tommaso Vinci, Alessandra Benuzzi-Mounaix, Jon Headspith, William Helsby, Simon Bland, Daniel Eakins, David Chapman, Sakura Pascarelli, Paul Loubeyre
Understanding Warm Dense Matter (WDM), the state of planetary interiors, is a new frontier in scientific research. There exists very little experimental data probing WDM states at the atomic level to test current models and those performed up to now are limited in quality. Here, we report a proof-of-principle experiment that makes microscopic investigations of materials under dynamic compression easily accessible to users and with data quality close to that achievable at ambient. Using a single 100 ps synchrotron x-ray pulse, we have measured, by K-edge absorption spectroscopy, ns-lived equilibrium states of WDM Fe...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27243349/compliance-and-subjective-patient-responses-to-eyelid-hygiene
#14
Yousef A Alghamdi, Andrew Camp, William Feuer, Carol L Karp, Sarah Wellik, Anat Galor
OBJECTIVES: Lid hygiene is a commonly prescribed first-line therapy in patients with lid margin disease, yet compliance with therapy is not well characterized. The goals of this study were to assess patient compliance with lid hygiene and evaluate which factors predict a favorable symptomatic response to treatment. METHODS: This was a cross-sectional study of patients seen in the Miami Veterans Affairs eye clinic between August and December 2014. An evaluation was performed to assess dry eye symptoms and lid margin signs...
May 26, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27236587/systemic-treatment-for-blepharokeratoconjunctivitis-in-children
#15
REVIEW
Michael O'Gallagher, Marina Banteka, Catey Bunce, Frank Larkin, Stephen Tuft, Annegret Dahlmann-Noor
BACKGROUND: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids which can affect children and adults. BKC involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms which include irritation, watering, photophobia and loss of vision. Loss of vision in children with BKC may be due to corneal opacity, refractive error or amblyopia...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27193942/dynamic-compression-of-dense-oxide-gd3ga5o12-from-0-4-to-2-6%C3%A2-tpa-universal-hugoniot-of-fluid-metals
#16
N Ozaki, W J Nellis, T Mashimo, M Ramzan, R Ahuja, T Kaewmaraya, T Kimura, M Knudson, K Miyanishi, Y Sakawa, T Sano, R Kodama
Materials at high pressures and temperatures are of great current interest for warm dense matter physics, planetary sciences, and inertial fusion energy research. Shock-compression equation-of-state data and optical reflectivities of the fluid dense oxide, Gd3Ga5O12 (GGG), were measured at extremely high pressures up to 2.6 TPa (26 Mbar) generated by high-power laser irradiation and magnetically-driven hypervelocity impacts. Above 0.75 TPa, the GGG Hugoniot data approach/reach a universal linear line of fluid metals, and the optical reflectivity most likely reaches a constant value indicating that GGG undergoes a crossover from fluid semiconductor to poor metal with minimum metallic conductivity (MMC)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27162126/in-vivo-heat-retention-comparison-of-eyelid-warming-masks
#17
Etty Bitton, Zoé Lacroix, Stéphanie Léger
PURPOSE: Meibomian gland dysfunction (MGD) is one of the most common causes of evaporative dry eye. Warm compresses (WC) are recommended as adjunct therapy to slowly transfer heat to the meibomian glands to melt or soften the stagnant meibum with targeted temperatures of 40-45°C. This clinical study evaluated the heat retention profiles of commercially available eyelid warming masks over a 12-min interval. METHODS: Five eyelid-warming masks (MGDRx Eyebag(®), EyeDoctor(®), Bruder(®), Tranquileyes XR™, Thera°Pearl(®)) were heated following manufacturer's instructions and heat retention was assessed at 1-min intervals for 12min...
August 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27100829/peripheral-nerve-dysfunction-in-middle-aged-subjects-born-with-thalidomide-embryopathy
#18
Alessia Nicotra, Claus Newman, Martin Johnson, Oleg Eremin, Tim Friede, Omar Malik, Richard Nicholas
BACKGROUND: Phocomelia is an extremely rare congenital malformation that emerged as one extreme of a range of defects resulting from in utero exposure to thalidomide. Individuals with thalidomide embryopathy (TE) have reported developing symptoms suggestive of peripheral nervous system dysfunction in the mal-developed limbs in later life. METHODS: Case control study comparing TE subjects with upper limb anomalies and neuropathic symptoms with healthy controls using standard neurophysiological testing...
2016: PloS One
https://www.readbyqxmd.com/read/27036457/first-principles-study-on-equation-of-states-and-electronic-structures-of-shock-compressed-ar-up-to-warm-dense-regime
#19
Huayang Sun, Dongdong Kang, Jiayu Dai, Wen Ma, Liangyuan Zhou, Jiaolong Zeng
The equation of states (EOS) and electronic structures of argon with temperatures from 0.02 eV to 3 eV and densities from 0.5 g/cm(3) to 5.5 g/cm(3) are calculated using the pair potential and many-body potential molecular dynamics and the density functional theory (DFT) molecular dynamics with van der Waals (vdW) corrections. First-principles molecular dynamics is implemented above 2.0 g/cm(3). For the cases of low densities below 3 g/cm(3), we performed pair potential molecular dynamics in order to obtain the ionic configurations, which are used in density functional theory to calculate the EOS and electronic structures...
March 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27035307/x-ray-thomson-scattering-in-warm-dense-matter-without-the-chihara-decomposition
#20
A D Baczewski, L Shulenburger, M P Desjarlais, S B Hansen, R J Magyar
X-ray Thomson scattering is an important experimental technique used to measure the temperature, ionization state, structure, and density of warm dense matter (WDM). The fundamental property probed in these experiments is the electronic dynamic structure factor. In most models, this is decomposed into three terms [J. Chihara, J. Phys. F 17, 295 (1987)] representing the response of tightly bound, loosely bound, and free electrons. Accompanying this decomposition is the classification of electrons as either bound or free, which is useful for gapped and cold systems but becomes increasingly questionable as temperatures and pressures increase into the WDM regime...
March 18, 2016: Physical Review Letters
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