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https://www.readbyqxmd.com/read/29775390/polarization-and-distribution-of-tumor-associated-macrophages-and-cox-2-expression-in-basal-cell-carcinoma-of-the-ocular-adnexae
#1
Ute Kaiser, Karin U Loeffler, Jennifer Nadal, Frank G Holz, Martina C Herwig-Carl
PURPOSE: Basal cell carcinoma (BCC) is a locally invasive skin tumor which can be subdivided into a circumscribed nodular and an invasive fibrosing subtype. There is increasing evidence that macrophages play an important role in interacting between tumor cells and their microenvironment, thereby affecting not only the invasive potential but also the patients' prognosis. Thus, we wanted to compare these two BCC variants with regard to tumor-related inflammation, COX-2 expression, distribution and polarization of tumor-associated macrophages...
May 18, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29771703/a-fatal-outcome-of-pica-syndrome-an-unusual-case-of-delayed-mortality
#2
Milenko Bogdanovic, Djordje Alempijevic, Djordje Curcic, Tijana Durmic
We present the case of a 42-year-old man, with a medical history of schizophrenic psychosis, who was found dead on the floor of his bedroom. At the autopsy, a bottle lid with a notched edge was found in the lower pharynx, partially obstructing the larynx and thus keeping the epiglottis in an open position. Airway obstruction was caused by edema and inflammation of the surrounding tissue. After removal of the foreign body, the tissue of the larynx was left with an impression of the bottle lid. The adjacent mucosa was swollen, hyperemic, partly necrotic, and covered with fibrin deposits...
May 16, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29675376/clinical-efficacy-of-combined-topical-0-05-cyclosporine-a-and-0-1-sodium-hyaluronate-in-the-dry-eyes-with-meibomian-gland-dysfunction
#3
Ho-Yun Kim, Ji-Eun Lee, Ha-Na Oh, Ju-Whan Song, Sang-Youp Han, Jong-Soo Lee
AIM: To investigate the efficacy of combined topical 0.05% cyclosporine A (CsA; Restasis® , Allergan pharmaceuticals, USA) and 0.1% sodium hyaluronate treatment in dry eyes with meibomian gland dysfunction (MGD). METHODS: In a retrospective analysis, 53 patients (106 eyes) with MGD were enrolled and performed lid warm massage for 10min daily and be instilled preservative free sodium hyaluronate 0.1% eye drops 4 times daily. Patients were divided into subjects treated with topical 0...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29666023/the-influence-of-lens-care-systems-on-eyelid-tissue-changes-during-silicone-hydrogel-contact-lens-wear
#4
Michel Guillon, Cécile Maissa, Stéphanie Wong, Trisha Patel, Renée Garofalo
PURPOSE: To compare the effects of a hydrogen peroxide (H2 O2 )-based lens care solution and a polyhexamethylene biguanide (PHMB) multi-purpose solution on the eyelids when used with silicone hydrogel (SiHy) contact lenses. METHODS: A total of 74 symptomatic wearers of ACUVUE® OASYS® (senofilcon A; n = 39) or PureVision® (balafilcon A; n = 35) contact lenses were randomised 1:1 to either CLEAR CARE® Cleaning & Disinfecting Solution or renu® fresh™ multi-purpose solution (n = 37 each)...
April 14, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29611150/nociceptive-response-to-l-dopa-induced-dyskinesia-in-hemiparkinsonian-rats
#5
G C Nascimento, K Bariotto-Dos-Santos, C R A Leite-Panissi, E A Del-Bel, M Bortolanza
Non-motor symptoms are increasingly identified to present clinical and diagnostic importance for Parkinson's disease (PD). The multifactorial origin of pain in PD makes this symptom of great complexity. The dopamine precursor, L-DOPA (L-3,4-dihydroxyphenylalanine), the classic therapy for PD, seems to be effective in pain threshold; however, there are no studies correlating L-DOPA-induced dyskinesia (LID) and nociception development in experimental Parkinsonism. Here, we first investigated nociceptive responses in a 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease to a hind paw-induced persistent inflammation...
April 2, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29610174/recalcitrant-atopic-keratoconjunctivitis-in-children-a-case-report-and-literature-review
#6
Jing Li, Xiaohui Luo, Hongmin Ke, Lingyi Liang
Atopic keratoconjunctivitis (AKC) is the most severe type of allergic conjunctivitis and may eventually lead to blindness. Although AKC is reported to be more prevalent in adults, we report a child with AKC whose clinical characteristics were not inconsistent with those typically seen in adult patients with AKC, and who was refractory to traditional topical anti-inflammatory and immunosuppressant therapies. An 11-year-old boy presented with a 3-month history of ocular redness and itching and decreased vision for a week in both eyes...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29573862/-ocular-surface-aging-pathophysiology-and-consequences-for-management
#7
REVIEW
T Audelan, M Legrand, M M'Garrech, A-L Best, E Barreau, M Labetoulle, A Rousseau
All the components of the ocular surface and the lacrimal system are affected by aging. Aging induces lacrimal gland fibrosis, Meibomian gland dysfunction, loss of corneal sensitivity, decreased corneal cell density, impairment of immune defences, increased local inflammation associated with hormonal changes, conjunctivochalasis, lid abnormalities, etc. Furthermore, homeostasis of the ocular surface may be altered by various age-related systemic comorbidities and iatrogenic interventions. Altogether, aging is considered the most predominant risk factor for dry eye disease...
March 21, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29468223/a-case-of-hypertrophic-herpes-simplex-virus-affecting-the-eyelid-and-cornea-masquerading-as-igg4-related-disease
#8
Prachi Dua, Roman Shinder, Derek B Laskar, Douglas R Lazzaro, Allison E Rizzuti
Purpose: To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease. Observations: A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upper and lower eyelids, and severe ocular inflammation with symblepharon...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29434822/the-role-of-dexamethasone-in-clinical-pharmaceutical-treatment-for-patients-with-cataract-surgery
#9
Gaokun Zhang, Shuang Liu, Lieying Yang, Yanqing Li
The aim of the present study is to determine the efficacy of dexamethasone (DEX) vs. indomethacin (IND) and ciprofloxacin (CIP) in modulating immediate inflammation following cataract surgery. A total of 644 patients with cataract were recruited and inflammation was investigated during the perioperative period. The management protocol was similar in both groups. Each drug was given four times a day for 30 days starting 7 days prior to surgery. The primary efficacy criteria for evaluation were the reduction in anterior chamber (AC) flare and AC inflammation score, in addition, a different secondary efficacy and safety evaluation criteria were maintained...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29128682/randomized-double-masked-trial-of-eyelid-cleansing-treatments-for-blepharitis
#10
Justin Sung, Michael T M Wang, Sang H Lee, Isabella M Y Cheung, Salim Ismail, Trevor Sherwin, Jennifer P Craig
PURPOSE: To compare the efficacy of a dedicated eyelid cleanser and diluted baby shampoo in the management of blepharitis. METHODS: Forty-three participants with clinical blepharitis signs were enrolled in a prospective, randomized, double-masked, paired-eye trial. A dedicated eyelid cleanser (TheraTears® SteriLid® ) was applied to the eyelids of one eye (randomized) and diluted baby shampoo (Johnson's® No More Tears® ) to the fellow eye, twice daily for 4 weeks...
January 2018: Ocular Surface
https://www.readbyqxmd.com/read/29033270/a-survey-of-contact-lens-related-complications-in-a-tertiary-hospital-in-china
#11
Weiwei Li, Xuguang Sun, Zhiqun Wang, Yang Zhang
PURPOSE: To describe the type of complications related to contact lens (CL) wear in a tertiary hospital in XX, China. METHODS: A retrospective study of 141 patients who complained discomfort after wearing contact lens on an outpatient basis of XX Hospital were conducted from the January 2012 to December 2015. The data included patients' demographics, lens type, history, slit-lamp examination, reports of corneal scrapings, culture, and examination of in vivo confocal microscopy...
October 12, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28950941/ocular-surface-inflammation-impairs-structure-and-function-of-meibomian-gland
#12
REVIEW
Shin Mizoguchi, Hiroki Iwanishi, Reiko Arita, Kumi Shirai, Takayoshi Sumioka, Masahide Kokado, James V Jester, Shizuya Saika
Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. The disorders include allergic conjunctivitis, long-term usage of contact lenses, dermatological diseases that affect conjunctival homeostasis, Stevens-Johnson's syndrome or chemical burning of the ocular surface and lid margin...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28935579/mechanisms-imaging-and-structure-of-tear-film-breakup
#13
REVIEW
P Ewen King-Smith, Carolyn G Begley, Richard J Braun
Tear film breakup (BU) is an important aspect of dry eye disease, as a cause of ocular aberrations, irritation and ocular surface inflammation and disorder. Additionally, measurement of breakup time (BUT) is a common clinical test for dry eye. The current definition of BUT is subjective; here, a more objective concept of "touchdown" - the moment when the lipid layer touches down on the corneal surface - is proposed as an aid to understanding processes in early and late stages of BU development. Models of BU have generally been based on the assumption that a single mechanism is involved...
January 2018: Ocular Surface
https://www.readbyqxmd.com/read/28922676/combination-therapy-of-intravenous-steroids-and-orbital-irradiation-is-more-effective-than-intravenous-steroids-alone-in-patients-with-graves-orbitopathy
#14
Michael Oeverhaus, Tobias Witteler, Hildegard Lax, Joachim Esser, Dagmar Führer, Anja Eckstein
The aim of this study was to evaluate and compare the efficacy of intravenous (iv) glucocorticoids (GCs) with and without orbital radiotherapy (ORT) in a retrospective analysis of patients with active, moderate-to-severe Graves' orbitopathy (GO). Since diplopia has the strongest impact on quality of life, a careful work up of motility and binocular single vision (BSV) has been performed. The Essen-EUGOGO-Center database (n=3655) was screened for patients with untreated moderate-to-severe, active GO, onset ≤12 months...
October 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28862259/lateral-canthotomy-orbitotomy-a-rapid-approach-to-the-orbit
#15
S Hamed-Azzam, D H Verity, G E Rose
PurposeThe lateral compartment of the orbit can readily be accessed through a horizontal lateral canthotomy without the need to swing the lid or remove bone. In this paper the technique, accessible orbital territory, and duration of surgery are presented.Patients and methodsRetrospective, non-interventional descriptive case series for patients who underwent a lateral canthotomy to access pathology within the lateral orbit.ResultsA series of 18 patients are included, all presenting with pathology lateral to, or within, the optic nerve...
February 2018: Eye
https://www.readbyqxmd.com/read/28736046/the-optical-imaging-of-tarantula-hair-corneal-injury-one-case-report-and-review-of-the-literature
#16
Yuedong Hu, Yuanyuan Xu
INTRODUCTION: Tarantulas belonging to the Theraphosidae family are more and more popular as family pets. Ocular injuries caused by tarantulas are reported in several articles. We hereby report the first known case of ocular injury caused by a tarantula in China and observed by anterior segment optical coherence tomography (AS-OCT). CASE: A 22-year-old girl was referred to our hospital with one-week history of red and irritated left eye after she grabbed her molting Chilean Rose Tarantula...
September 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28602547/non-invasive-objective-and-contemporary-methods-for-measuring-ocular-surface-inflammation-in-soft-contact-lens-wearers-a-review
#17
REVIEW
Cecilia Chao, Kathryn Richdale, Isabelle Jalbert, Kim Doung, Moneisha Gokhale
Contact lens wear is one of the primary risk factors for the development of ocular surface inflammatory events. The purpose of this review is to examine and summarize existing knowledge on the mechanisms of contact lens related ocular surface inflammation and the evidence for the effectiveness of current objective methods to measure ocular surface inflammation. Contact lens wear is postulated to trigger an inflammatory response on the ocular surface due to mechanical, chemical, hypoxic stress, or by the introduction of microbes and their toxins...
October 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28592257/clinical-safety-and-efficacy-of-vitamin-d3-analog-ointment-for-treatment-of-obstructive-meibomian-gland-dysfunction
#18
RANDOMIZED CONTROLLED TRIAL
Reiko Arita, Motoko Kawashima, Masataka Ito, Kazuo Tsubota
BACKGROUND: Hyperkeratinization is a major cause of obstructive meibomian gland dysfunction (oMGD) and results in degenerative gland dilation and atrophy without inflammation. Ointment containing 1,25-dihydroxy-22-oxavitamin D3 (maxacalcitol), a noncalcemic analog of the active form of vitamin D3, is applied for the treatment of hyperkeratotic cutaneous conditions such as psoriasis and ichtyosis because it suppresses the proliferation and promotes the differentiation of keratinocytes through interaction with the vitamin D receptor...
June 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28585267/intense-pulsed-light-treatment-and-meibomian-gland-expression-for-moderate-to-advanced-meibomian-gland-dysfunction
#19
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of periocular intense pulsed light therapy combined with meibomian gland expression for chronic dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This single-institution, open-label prospective study involved 26 participants who received bilateral treatments using a proprietary intense pulsed light device (E > Eye, E-Swin, Paris, France) combined with therapeutic meibomian gland expression at baseline, Week 2 and Week 6...
January 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28399069/conjunctival-limbal-autograft
#20
REVIEW
Sheraz M Daya
PURPOSE OF REVIEW: To provide an overview of conjunctival-limbal autografting (CLAU) for ocular surface rehabilitation with emphasis on more recent literature detailing outcomes of the procedure over the last 2 decades as well as technique variations and adjuvant techniques. RECENT FINDINGS: Limbal autografting initially described in 1964 by Barraquer and Strampelli and later popularized by Kenyon and Tseng is considered the best option for restoration of corneal phenotype in unilateral limbal stem-cell deficiency...
July 2017: Current Opinion in Ophthalmology
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